Phosphocreatine (BioDeep_00000399955)

Main id: BioDeep_00000002691

 

natural product BioNovoGene_Lab2019


代谢物信息卡片


Phosphocreatine

化学式: C4H10N3O5P (211.0358)
中文名称: 磷酸肌酸, 磷酸肌酸 二钠盐 水合物, 肌酸磷酸氢二钠四水合物
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN(CC(=O)O)/C(=N/P(=O)(O)O)/N
InChI: InChI=1S/C4H10N3O5P/c1-7(2-3(8)9)4(5)6-13(10,11)12/h2H2,1H3,(H,8,9)(H4,5,6,10,11,12)

描述信息

D020011 - Protective Agents > D002316 - Cardiotonic Agents
C - Cardiovascular system > C01 - Cardiac therapy
D002317 - Cardiovascular Agents

同义名列表

2 个代谢物同义名

Phosphocreatine; Phosphocreatine



数据库引用编号

29 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

24 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 AKT1, AXIN2, BCL2, CASP3, CASP9, DMD, ITPR3, MYLK, PIK3C2A, PKM, PRKAA2
Peripheral membrane protein 1 DMD
Endoplasmic reticulum membrane 2 BCL2, ITPR3
Nucleus 10 AKT1, AXIN2, BCL2, CASP3, CASP9, CS, DMD, PIK3C2A, PKM, PRKAA2
cytosol 14 AKT1, AXIN2, BCL2, CASP3, CASP9, CKB, DMD, MYLK, NT5E, PIK3C2A, PKM, PRKAA2, PRKCQ, SLC2A4
dendrite 1 PRKAA2
trans-Golgi network 2 PIK3C2A, SLC2A4
centrosome 1 AXIN2
nucleoplasm 7 AKT1, ATP2B1, CASP3, ITPR3, NT5E, PIK3C2A, PRKAA2
Cell membrane 7 AKT1, ATP2B1, CKB, NT5E, PIK3C2A, SLC2A4, SLC6A8
Cytoplasmic side 1 DMD
Cleavage furrow 1 MYLK
lamellipodium 2 AKT1, MYLK
Multi-pass membrane protein 4 ATP2B1, ITPR3, SLC2A4, SLC6A8
Synapse 3 ATP2B1, DMD, MYLK
cell cortex 1 AKT1
cell surface 2 DMD, NT5E
glutamatergic synapse 3 AKT1, ATP2B1, CASP3
Golgi apparatus 1 PRKAA2
Golgi membrane 1 INS
mitochondrial inner membrane 1 GATM
neuronal cell body 3 CASP3, ITPR3, PRKAA2
postsynapse 1 AKT1
presynaptic membrane 1 ATP2B1
sarcolemma 2 DMD, SLC2A4
Cytoplasm, cytosol 1 CKB
Presynapse 1 SLC2A4
plasma membrane 12 AKT1, ATP2B1, AXIN2, CKB, DMD, ITPR3, MYLK, NT5E, PIK3C2A, PRKCQ, SLC2A4, SLC6A8
synaptic vesicle membrane 1 ATP2B1
Membrane 11 AKT1, ATP2B1, BCL2, CS, DMD, ITPR3, NT5E, PIK3C2A, PRKAA2, SLC2A4, SLC6A8
apical plasma membrane 1 SLC6A8
axon 1 PRKAA2
basolateral plasma membrane 1 ATP2B1
brush border 1 ITPR3
extracellular exosome 8 ATP2B1, CKB, CS, GATM, NT5E, PIK3C2A, PKM, SLC2A4
endoplasmic reticulum 2 BCL2, ITPR3
extracellular space 2 CKB, INS
perinuclear region of cytoplasm 1 SLC2A4
mitochondrion 6 BCL2, CASP9, CKB, CS, GATM, PKM
protein-containing complex 4 AKT1, BCL2, CASP9, DMD
intracellular membrane-bounded organelle 2 ATP2B1, PIK3C2A
filopodium 1 DMD
postsynaptic density 1 CASP3
Secreted 1 INS
extracellular region 2 INS, PKM
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
Mitochondrion matrix 1 CS
mitochondrial matrix 1 CS
centriolar satellite 1 PRKCQ
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 NT5E, SLC2A4
Extracellular vesicle 1 PKM
multivesicular body 1 SLC2A4
actin cytoskeleton 1 MYLK
T-tubule 1 SLC2A4
Z disc 1 DMD
beta-catenin destruction complex 1 AXIN2
microtubule cytoskeleton 1 AKT1
nucleolus 1 ITPR3
apical part of cell 1 ITPR3
cell-cell junction 1 AKT1
clathrin-coated pit 1 SLC2A4
vesicle 3 AKT1, PIK3C2A, PKM
postsynaptic membrane 1 DMD
Apical cell membrane 1 SLC6A8
Cell membrane, sarcolemma 1 DMD
Cell projection, lamellipodium 1 MYLK
Cytoplasm, perinuclear region 1 SLC2A4
Mitochondrion inner membrane 1 GATM
Membrane raft 2 DMD, SLC2A4
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 DMD
spindle 1 AKT1
sarcoplasmic reticulum 2 ITPR3, SLC2A4
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 2 AKT1, GATM
collagen-containing extracellular matrix 1 PKM
lateral plasma membrane 1 ATP2B1
nuclear speck 1 PRKAA2
Nucleus outer membrane 1 DMD
nuclear outer membrane 2 DMD, ITPR3
Postsynaptic cell membrane 1 DMD
receptor complex 1 ITPR3
ciliary basal body 1 AKT1
cilium 1 PKM
cell projection 1 ATP2B1
cytoskeleton 1 DMD
Golgi apparatus, trans-Golgi network 1 PIK3C2A
Basolateral cell membrane 1 ATP2B1
Lipid-anchor, GPI-anchor 1 NT5E
Endomembrane system 1 SLC2A4
endosome lumen 1 INS
Cytoplasmic vesicle membrane 1 SLC2A4
cytoplasmic stress granule 1 PRKAA2
Presynaptic cell membrane 1 ATP2B1
side of membrane 1 NT5E
myelin sheath 1 BCL2
filopodium membrane 1 DMD
stress fiber 1 MYLK
clathrin-coated vesicle 2 PIK3C2A, SLC2A4
trans-Golgi network transport vesicle 1 SLC2A4
ficolin-1-rich granule lumen 1 PKM
secretory granule lumen 2 INS, PKM
secretory granule membrane 1 ITPR3
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
phosphatidylinositol 3-kinase complex 1 PIK3C2A
Cytoplasmic vesicle, clathrin-coated vesicle 1 PIK3C2A
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 2 ATP2B1, PRKCQ
aggresome 1 PRKCQ
Single-pass type IV membrane protein 1 DMD
apoptosome 1 CASP9
vesicle membrane 1 SLC2A4
Cytoplasm, cytoskeleton, stress fiber 1 MYLK
platelet dense tubular network membrane 1 ITPR3
costamere 1 DMD
death-inducing signaling complex 1 CASP3
dystrophin-associated glycoprotein complex 1 DMD
Cytoplasmic vesicle, secretory vesicle membrane 1 ITPR3
Rough endoplasmic reticulum 1 PKM
nucleotide-activated protein kinase complex 1 PRKAA2
cell-substrate junction 1 DMD
transport vesicle membrane 1 ITPR3
neuron projection terminus 1 DMD
BAD-BCL-2 complex 1 BCL2
photoreceptor ribbon synapse 1 ATP2B1
syntrophin complex 1 DMD
[Isoform M2]: Cytoplasm 1 PKM
[Isoform M1]: Cytoplasm 1 PKM
insulin-responsive compartment 1 SLC2A4
cytoplasmic side of endoplasmic reticulum membrane 1 ITPR3
caspase complex 1 CASP9
organelle 1 DMD
plasma membrane bounded cell projection 1 DMD


文献列表

  • Ming-Wei Liu, Chun-Hai Zhang, Qiu-Juan Zhang, Bing-Ran Zhang. Rhabdomyolysis caused by Botrychium ternatum intoxication: Case report and literature review. Medicine. 2024 Mar; 103(9):e37304. doi: 10.1097/md.0000000000037304. [PMID: 38428852]
  • Xiangyu Liu, Bo Zhang, Junsheng Tian, Yumei Han. Plasma metabolomics reveals the intervention mechanism of different types of exercise on chronic unpredictable mild stress-induced depression rat model. Metabolic brain disease. 2024 Jan; 39(1):1-13. doi: 10.1007/s11011-023-01310-7. [PMID: 37999885]
  • Shveta Monga, Ladislav Valkovič, Saul G Myerson, Stefan Neubauer, Masliza Mahmod, Oliver J Rider. Role of Cardiac Energetics in Aortic Stenosis Disease Progression: Identifying the High-risk Metabolic Phenotype. Circulation. Cardiovascular imaging. 2023 10; 16(10):e014863. doi: 10.1161/circimaging.122.014863. [PMID: 37847766]
  • Hechuan Wang, Minghui Guo, Tianfeng Li, Han Zhang, Qian Wang, Qun Zhang, Yulun Song, Heze Feng, Yanbing Li, Guosheng Wei, Jingchun Li. Phosphocreatine addition to extender enhances the quality and antioxidant capacity of cryopreserved boar sperm. Reproduction in domestic animals = Zuchthygiene. 2023 Jun; ?(?):. doi: 10.1111/rda.14404. [PMID: 37313775]
  • Ping-An Yao, Ke-Zhao Wei, Jia-Hua Feng, Xiao-Ning Liu, Xu Xu, Hong-Yan Cui, Xiao-Chen Zhang, Jian-Ping Gao. Sodium houttuyfonate protects against cardiac injury by regulating cardiac energy metabolism in diabetic rats. European journal of pharmacology. 2022 Oct; 932(?):175236. doi: 10.1016/j.ejphar.2022.175236. [PMID: 36044971]
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  • Salwan Maqdasy, Simon Lecoutre, Gianluca Renzi, Scott Frendo-Cumbo, David Rizo-Roca, Thomas Moritz, Marta Juvany, Ondrej Hodek, Hui Gao, Morgane Couchet, Michael Witting, Alastair Kerr, Martin O Bergo, Robin P Choudhury, Myriam Aouadi, Juleen R Zierath, Anna Krook, Niklas Mejhert, Mikael Rydén. Impaired phosphocreatine metabolism in white adipocytes promotes inflammation. Nature metabolism. 2022 02; 4(2):190-202. doi: 10.1038/s42255-022-00525-9. [PMID: 35165448]
  • Shu Yang, Lei Guo, Duozi Wang, Yanwei Yang, Jianhong Wang. Research on Mechanism of miR-106a Nanoparticles Carrying Dexmedetomidine in Regulating Recovery and Metabolism of Nerve Cells in Hypoxia-Reoxygenation Injury. Journal of biomedical nanotechnology. 2022 Feb; 18(2):343-351. doi: 10.1166/jbn.2022.3244. [PMID: 35484744]
  • John Paul V Anders, Tyler J Neltner, Robert W Smith, Joshua L Keller, Terry J Housh, F Joseph Daugherty, Michael S Tempesta, Alekha K Dash, Daniel J Munt, Richard J Schmidt, Glen O Johnson. The effects of phosphocreatine disodium salts plus blueberry extract supplementation on muscular strength, power, and endurance. Journal of the International Society of Sports Nutrition. 2021 Sep; 18(1):60. doi: 10.1186/s12970-021-00456-y. [PMID: 34503541]
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  • Lisha Joshi, Ioanna Plastira, Eva Bernhart, Helga Reicher, Chintan N Koyani, Tobias Madl, Corina Madreiter-Sokolowski, Zhanat Koshenov, Wolfgang F Graier, Seth Hallström, Wolfgang Sattler. Lysophosphatidic Acid Induces Aerobic Glycolysis, Lipogenesis, and Increased Amino Acid Uptake in BV-2 Microglia. International journal of molecular sciences. 2021 Feb; 22(4):. doi: 10.3390/ijms22041968. [PMID: 33671212]
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  • Kirill Gorshkov, Amy Q Wang, Wei Sun, Ethan Fisher, Marta Frigeni, Marc Singleton, Natasha Thorne, Bradley Class, Wenwei Huang, Nicola Longo, Minh-Ha T Do, Elizabeth A Ottinger, Xin Xu, Wei Zheng. Phosphocyclocreatine is the dominant form of cyclocreatine in control and creatine transporter deficiency patient fibroblasts. Pharmacology research & perspectives. 2019 12; 7(6):e00525. doi: 10.1002/prp2.525. [PMID: 31859463]
  • Heng Xi, Ailin Zhang, Guozhu Han, Chuanxun Li, Li Lv. Pharmacokinetics and hemorheology of phosphocreatine and creatine in rabbits: A directly comparative study between parent drug and active metabolite. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2019 Oct; 138(?):105033. doi: 10.1016/j.ejps.2019.105033. [PMID: 31382031]
  • Ning Sun, Qirui Li, Libo Zhao, Huan He, Meng Zhang, Xiaoling Wang. Simultaneous quantitative analysis of phosphocreatine, creatine and creatinine in plasma of children by HPLC-MS/MS method: Application to a pharmacokinetic study in children with viral myocarditis. Biomedical chromatography : BMC. 2019 Aug; 33(8):e4558. doi: 10.1002/bmc.4558. [PMID: 31013362]
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  • Masliza Mahmod, Nikhil Pal, Jennifer Rayner, Cameron Holloway, Betty Raman, Sairia Dass, Eylem Levelt, Rina Ariga, Vanessa Ferreira, Rajarshi Banerjee, Jurgen E Schneider, Christopher Rodgers, Jane M Francis, Theodoros D Karamitsos, Michael Frenneaux, Houman Ashrafian, Stefan Neubauer, Oliver Rider. The interplay between metabolic alterations, diastolic strain rate and exercise capacity in mild heart failure with preserved ejection fraction: a cardiovascular magnetic resonance study. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance. 2018 12; 20(1):88. doi: 10.1186/s12968-018-0511-6. [PMID: 30580760]
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