Phosphocreatine (BioDeep_00000399955)

Main id: BioDeep_00000002691

 

natural product


代谢物信息卡片


Phosphocreatine

化学式: C4H10N3O5P (211.035806)
中文名称: 磷酸肌酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN(CC(=O)O)/C(=N/P(=O)(O)O)/N
InChI: InChI=1S/C4H10N3O5P/c1-7(2-3(8)9)4(5)6-13(10,11)12/h2H2,1H3,(H,8,9)(H4,5,6,10,11,12)

描述信息

D020011 - Protective Agents > D002316 - Cardiotonic Agents
C - Cardiovascular system > C01 - Cardiac therapy
D002317 - Cardiovascular Agents

同义名列表

1 个代谢物同义名

Phosphocreatine



数据库引用编号

25 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

8 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ming-Wei Liu, Chun-Hai Zhang, Qiu-Juan Zhang, Bing-Ran Zhang. Rhabdomyolysis caused by Botrychium ternatum intoxication: Case report and literature review. Medicine. 2024 Mar; 103(9):e37304. doi: 10.1097/md.0000000000037304. [PMID: 38428852]
  • Xiangyu Liu, Bo Zhang, Junsheng Tian, Yumei Han. Plasma metabolomics reveals the intervention mechanism of different types of exercise on chronic unpredictable mild stress-induced depression rat model. Metabolic brain disease. 2024 Jan; 39(1):1-13. doi: 10.1007/s11011-023-01310-7. [PMID: 37999885]
  • Shveta Monga, Ladislav Valkovič, Saul G Myerson, Stefan Neubauer, Masliza Mahmod, Oliver J Rider. Role of Cardiac Energetics in Aortic Stenosis Disease Progression: Identifying the High-risk Metabolic Phenotype. Circulation. Cardiovascular imaging. 2023 10; 16(10):e014863. doi: 10.1161/circimaging.122.014863. [PMID: 37847766]
  • Hechuan Wang, Minghui Guo, Tianfeng Li, Han Zhang, Qian Wang, Qun Zhang, Yulun Song, Heze Feng, Yanbing Li, Guosheng Wei, Jingchun Li. Phosphocreatine addition to extender enhances the quality and antioxidant capacity of cryopreserved boar sperm. Reproduction in domestic animals = Zuchthygiene. 2023 Jun; ?(?):. doi: 10.1111/rda.14404. [PMID: 37313775]
  • Ping-An Yao, Ke-Zhao Wei, Jia-Hua Feng, Xiao-Ning Liu, Xu Xu, Hong-Yan Cui, Xiao-Chen Zhang, Jian-Ping Gao. Sodium houttuyfonate protects against cardiac injury by regulating cardiac energy metabolism in diabetic rats. European journal of pharmacology. 2022 Oct; 932(?):175236. doi: 10.1016/j.ejphar.2022.175236. [PMID: 36044971]
  • Ming-Ying Ling, Yi-Ping Song, Chun Liu, Zhi-Hao Wang, Yan Wang, Xue-Hui Li, Zhen Zhang, Rong-Xiang Zhou, Liang-Yi Qie, Man Li, Yun-Ling Xiao, Huan-Qin Chen, Yan-Qiu Xing. Protection of Exogenous Phosphocreatine for Myocardium in Percutaneous Coronary Intervention Related to Inflammation. Reviews in cardiovascular medicine. 2022 Mar; 23(3):89. doi: 10.31083/j.rcm2303089. [PMID: 35345256]
  • Salwan Maqdasy, Simon Lecoutre, Gianluca Renzi, Scott Frendo-Cumbo, David Rizo-Roca, Thomas Moritz, Marta Juvany, Ondrej Hodek, Hui Gao, Morgane Couchet, Michael Witting, Alastair Kerr, Martin O Bergo, Robin P Choudhury, Myriam Aouadi, Juleen R Zierath, Anna Krook, Niklas Mejhert, Mikael Rydén. Impaired phosphocreatine metabolism in white adipocytes promotes inflammation. Nature metabolism. 2022 02; 4(2):190-202. doi: 10.1038/s42255-022-00525-9. [PMID: 35165448]
  • Shu Yang, Lei Guo, Duozi Wang, Yanwei Yang, Jianhong Wang. Research on Mechanism of miR-106a Nanoparticles Carrying Dexmedetomidine in Regulating Recovery and Metabolism of Nerve Cells in Hypoxia-Reoxygenation Injury. Journal of biomedical nanotechnology. 2022 Feb; 18(2):343-351. doi: 10.1166/jbn.2022.3244. [PMID: 35484744]
  • John Paul V Anders, Tyler J Neltner, Robert W Smith, Joshua L Keller, Terry J Housh, F Joseph Daugherty, Michael S Tempesta, Alekha K Dash, Daniel J Munt, Richard J Schmidt, Glen O Johnson. The effects of phosphocreatine disodium salts plus blueberry extract supplementation on muscular strength, power, and endurance. Journal of the International Society of Sports Nutrition. 2021 Sep; 18(1):60. doi: 10.1186/s12970-021-00456-y. [PMID: 34503541]
  • P G Wibowo, S J Charman, N C Okwose, L Velicki, D Popovic, K G Hollingsworth, G A Macgowan, D G Jakovljevic. Association between cardiac high-energy phosphate metabolism and whole body metabolism in healthy female adults. Physiological research. 2021 07; 70(3):393-399. doi: 10.33549/physiolres.934627. [PMID: 33982584]
  • Salwa A Elgebaly, Robert Todd, Donald L Kreutzer, Robert Christenson, Nashwa El-Khazragy, Reem K Arafa, Mostafa A Rabie, Ahmed F Mohamed, Lamiaa A Ahmed, Nesrine S El Sayed. Nourin-Associated miRNAs: Novel Inflammatory Monitoring Markers for Cyclocreatine Phosphate Therapy in Heart Failure. International journal of molecular sciences. 2021 Mar; 22(7):. doi: 10.3390/ijms22073575. [PMID: 33808213]
  • Lisha Joshi, Ioanna Plastira, Eva Bernhart, Helga Reicher, Chintan N Koyani, Tobias Madl, Corina Madreiter-Sokolowski, Zhanat Koshenov, Wolfgang F Graier, Seth Hallström, Wolfgang Sattler. Lysophosphatidic Acid Induces Aerobic Glycolysis, Lipogenesis, and Increased Amino Acid Uptake in BV-2 Microglia. International journal of molecular sciences. 2021 Feb; 22(4):. doi: 10.3390/ijms22041968. [PMID: 33671212]
  • Guillaume Chazot, Sandrine Lemoine, Gabriel Kocevar, Emilie Kalbacher, Dominique Sappey-Marinier, Olivier Rouvière, Laurent Juillard. Intracellular Phosphate and ATP Depletion Measured by Magnetic Resonance Spectroscopy in Patients Receiving Maintenance Hemodialysis. Journal of the American Society of Nephrology : JASN. 2021 01; 32(1):229-237. doi: 10.1681/asn.2020050716. [PMID: 33093193]
  • Yi Wang, Jin-Fang Chen, Pengyu Li, Jia-Hong Gao. Quantifying the fractional concentrations and exchange rates of small-linewidth CEST agents using the QUCESOP method under multi-solute conditions in MRI signals. Magnetic resonance in medicine. 2021 01; 85(1):268-280. doi: 10.1002/mrm.28436. [PMID: 32726502]
  • William D Watson, Kerstin N Timm, Andrew J Lewis, Jack J J Miller, Yaso Emmanuel, Kieran Clarke, Stefan Neubauer, Damian J Tyler, Oliver J Rider. Nicotinic acid receptor agonists impair myocardial contractility by energy starvation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020 11; 34(11):14878-14891. doi: 10.1096/fj.202000084rr. [PMID: 32954525]
  • Alessandra Palma, Sveva Grande, Lucia Ricci-Vitiani, Anna Maria Luciani, Mariachiara Buccarelli, Mauro Biffoni, Valentina Dini, Giuseppe A P Cirrone, Mario Ciocca, Laura Guidoni, Roberto Pallini, Vincenza Viti, Antonella Rosi. Different Mechanisms Underlie the Metabolic Response of GBM Stem-Like Cells to Ionizing Radiation: Biological and MRS Studies on Effects of Photons and Carbon Ions. International journal of molecular sciences. 2020 Jul; 21(14):. doi: 10.3390/ijms21145167. [PMID: 32708312]
  • Jorge L Gamboa, Baback Roshanravan, Theodore Towse, Chad A Keller, Aaron M Falck, Chang Yu, Walter R Frontera, Nancy J Brown, T Alp Ikizler. Skeletal Muscle Mitochondrial Dysfunction Is Present in Patients with CKD before Initiation of Maintenance Hemodialysis. Clinical journal of the American Society of Nephrology : CJASN. 2020 07; 15(7):926-936. doi: 10.2215/cjn.10320819. [PMID: 32591419]
  • KowsalyaDevi Pavuluri, Jens T Rosenberg, Shannon Helsper, Shaowei Bo, Michael T McMahon. Amplified detection of phosphocreatine and creatine after supplementation using CEST MRI at high and ultrahigh magnetic fields. Journal of magnetic resonance (San Diego, Calif. : 1997). 2020 04; 313(?):106703. doi: 10.1016/j.jmr.2020.106703. [PMID: 32179431]
  • Margarida Souto-Carneiro, Lilla Tóth, Rouven Behnisch, Konstantin Urbach, Karel D Klika, Rui A Carvalho, Hanns-Martin Lorenz. Differences in the serum metabolome and lipidome identify potential biomarkers for seronegative rheumatoid arthritis versus psoriatic arthritis. Annals of the rheumatic diseases. 2020 04; 79(4):499-506. doi: 10.1136/annrheumdis-2019-216374. [PMID: 32079570]
  • Dong-Min Cao, Qin-Xiao Guan, Ya-Li Liu, Shu-Mei Wang. [Effect of ginsenosides on serous metabonomic profiles in cerebral ischemia-reperfusion rats based on ~1H-NMR]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2020 Mar; 45(5):1142-1148. doi: 10.19540/j.cnki.cjcmm.20190619.505. [PMID: 32237458]
  • Abdullah Shopit, Mengyue Niu, Hongyan Wang, Zhongyuan Tang, Xiaodong Li, Tsehaye Tesfaldet, Jie Ai, Nisar Ahmad, Mahmoud Al-Azab, Zeyao Tang. Protection of diabetes-induced kidney injury by phosphocreatine via the regulation of ERK/Nrf2/HO-1 signaling pathway. Life sciences. 2020 Feb; 242(?):117248. doi: 10.1016/j.lfs.2019.117248. [PMID: 31899224]
  • Kirill Gorshkov, Amy Q Wang, Wei Sun, Ethan Fisher, Marta Frigeni, Marc Singleton, Natasha Thorne, Bradley Class, Wenwei Huang, Nicola Longo, Minh-Ha T Do, Elizabeth A Ottinger, Xin Xu, Wei Zheng. Phosphocyclocreatine is the dominant form of cyclocreatine in control and creatine transporter deficiency patient fibroblasts. Pharmacology research & perspectives. 2019 12; 7(6):e00525. doi: 10.1002/prp2.525. [PMID: 31859463]
  • Heng Xi, Ailin Zhang, Guozhu Han, Chuanxun Li, Li Lv. Pharmacokinetics and hemorheology of phosphocreatine and creatine in rabbits: A directly comparative study between parent drug and active metabolite. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2019 Oct; 138(?):105033. doi: 10.1016/j.ejps.2019.105033. [PMID: 31382031]
  • Ning Sun, Qirui Li, Libo Zhao, Huan He, Meng Zhang, Xiaoling Wang. Simultaneous quantitative analysis of phosphocreatine, creatine and creatinine in plasma of children by HPLC-MS/MS method: Application to a pharmacokinetic study in children with viral myocarditis. Biomedical chromatography : BMC. 2019 Aug; 33(8):e4558. doi: 10.1002/bmc.4558. [PMID: 31013362]
  • Gessica Perin, Matheus D Baldissera, Antonise M Jaguezeski, Regiane B Crecencio, Lenita M Stefani, Anderson Gris, Ricardo E Mendes, Carine F Souza, Vanessa Dalzuk, Aleksandro S da Silva. Involvement of the phosphoryl transfer network on cardiac energetic metabolism during Staphylococcus aureus infection and its association to disease pathophysiology. Microbial pathogenesis. 2019 Jan; 126(?):318-322. doi: 10.1016/j.micpath.2018.11.011. [PMID: 30439401]
  • Masliza Mahmod, Nikhil Pal, Jennifer Rayner, Cameron Holloway, Betty Raman, Sairia Dass, Eylem Levelt, Rina Ariga, Vanessa Ferreira, Rajarshi Banerjee, Jurgen E Schneider, Christopher Rodgers, Jane M Francis, Theodoros D Karamitsos, Michael Frenneaux, Houman Ashrafian, Stefan Neubauer, Oliver Rider. The interplay between metabolic alterations, diastolic strain rate and exercise capacity in mild heart failure with preserved ejection fraction: a cardiovascular magnetic resonance study. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance. 2018 12; 20(1):88. doi: 10.1186/s12968-018-0511-6. [PMID: 30580760]
  • Erika M Ripley, Geoffrey D Clarke, Vala Hamidi, Robert A Martinez, Floyd D Settles, Carolina Solis, Shengwen Deng, Muhammad Abdul-Ghani, Devjit Tripathy, Ralph A DeFronzo. Reduced skeletal muscle phosphocreatine concentration in type 2 diabetic patients: a quantitative image-based phosphorus-31 MR spectroscopy study. American journal of physiology. Endocrinology and metabolism. 2018 08; 315(2):E229-E239. doi: 10.1152/ajpendo.00426.2017. [PMID: 29509433]
  • Lin Chen, Haifeng Zeng, Xiang Xu, Nirbhay N Yadav, Shuhui Cai, Nicolaas A Puts, Peter B Barker, Tong Li, Robert G Weiss, Peter C M van Zijl, Jiadi Xu. Investigation of the contribution of total creatine to the CEST Z-spectrum of brain using a knockout mouse model. NMR in biomedicine. 2017 Dec; 30(12):. doi: 10.1002/nbm.3834. [PMID: 28961344]
  • W Kyle Mitchell, Bethan E Phillips, Ian Hill, Paul Greenhaff, Jonathan N Lund, John P Williams, Debbie Rankin, Daniel J Wilkinson, Kenneth Smith, Philip J Atherton. Human skeletal muscle is refractory to the anabolic effects of leucine during the postprandial muscle-full period in older men. Clinical science (London, England : 1979). 2017 Nov; 131(21):2643-2653. doi: 10.1042/cs20171230. [PMID: 28982725]
  • Matheus D Baldissera, Carine F Souza, Guerino B Júnior, Camila Marina Verdi, Karen L S Moreira, Maria Izabel U M da Rocha, Marcelo L da Veiga, Roberto C V Santos, Bruno S Vizzotto, Bernardo Baldisserotto. Aeromonas caviae alters the cytosolic and mitochondrial creatine kinase activities in experimentally infected silver catfish: Impairment on renal bioenergetics. Microbial pathogenesis. 2017 Sep; 110(?):439-443. doi: 10.1016/j.micpath.2017.07.031. [PMID: 28735082]
  • Lotte Lindberg, Kasper Brødbæk, Erik G Hägerström, Jens Bentzen, Bent Kristensen, Bo Zerahn. Comparison of methods for estimating glomerular filtration rate in head and neck cancer patients treated with cisplatin. Scandinavian journal of clinical and laboratory investigation. 2017 Jul; 77(4):237-246. doi: 10.1080/00365513.2017.1298001. [PMID: 28317454]
  • Greg D Wells, Laura Banks, Jessica E Caterini, Sara Thompson, Michael D Noseworthy, Tammy Rayner, Catriona Syme, Brian W McCrindle, Jill Hamilton. The association among skeletal muscle phosphocreatine recovery, adiposity, and insulin resistance in children. Pediatric obesity. 2017 04; 12(2):163-170. doi: 10.1111/ijpo.12123. [PMID: 26916682]
  • Malte Stockebrand, Ali Sasani Nejad, Axel Neu, Kusum K Kharbanda, Kathrin Sauter, Stefan Schillemeit, Dirk Isbrandt, Chi-Un Choe. Transcriptomic and metabolic analyses reveal salvage pathways in creatine-deficient AGAT(-/-) mice. Amino acids. 2016 08; 48(8):2025-39. doi: 10.1007/s00726-016-2202-7. [PMID: 26940723]
  • Scott Betteridge, Raúl Bescós, Miquel Martorell, Antoni Pons, Andrew P Garnham, Christos C Stathis, Glenn K McConell. No effect of acute beetroot juice ingestion on oxygen consumption, glucose kinetics, or skeletal muscle metabolism during submaximal exercise in males. Journal of applied physiology (Bethesda, Md. : 1985). 2016 Feb; 120(4):391-8. doi: 10.1152/japplphysiol.00658.2015. [PMID: 26635348]
  • Alexandre Fouré, Kazunori Nosaka, Marguerite Gastaldi, Jean-Pierre Mattei, Hélène Boudinet, Maxime Guye, Christophe Vilmen, Yann Le Fur, David Bendahan, Julien Gondin. Effects of branched-chain amino acids supplementation on both plasma amino acids concentration and muscle energetics changes resulting from muscle damage: A randomized placebo controlled trial. Clinical nutrition (Edinburgh, Scotland). 2016 Feb; 35(1):83-94. doi: 10.1016/j.clnu.2015.03.014. [PMID: 25886707]
  • Yukinori Nishigami, Hiroaki Ito, Seiji Sonobe, Masatoshi Ichikawa. Non-periodic oscillatory deformation of an actomyosin microdroplet encapsulated within a lipid interface. Scientific reports. 2016 Jan; 6(?):18964. doi: 10.1038/srep18964. [PMID: 26754862]
  • Suman Pradhan, Christine Pellino, Kayleigh MacMaster, Dennis Coyle, Alison A Weiss. Shiga Toxin Mediated Neurologic Changes in Murine Model of Disease. Frontiers in cellular and infection microbiology. 2016; 6(?):114. doi: 10.3389/fcimb.2016.00114. [PMID: 27747196]
  • E F Diekman, G Visser, J P J Schmitz, R A J Nievelstein, M de Sain-van der Velden, M Wardrop, W L Van der Pol, S M Houten, N A W van Riel, T Takken, J A L Jeneson. Altered Energetics of Exercise Explain Risk of Rhabdomyolysis in Very Long-Chain Acyl-CoA Dehydrogenase Deficiency. PloS one. 2016; 11(2):e0147818. doi: 10.1371/journal.pone.0147818. [PMID: 26881790]
  • Marina Yazigi Solis, Ana Paula Hayashi, Guilherme Giannini Artioli, Hamilton Roschel, Marcelo Tatit Sapienza, Maria Concepción Otaduy, Ana Lucia De Sã Pinto, Clovis Artur Silva, Adriana Maluf Elias Sallum, Rosa Maria R Pereira, Bruno Gualano. Efficacy and safety of creatine supplementation in juvenile dermatomyositis: A randomized, double-blind, placebo-controlled crossover trial. Muscle & nerve. 2016 Jan; 53(1):58-66. doi: 10.1002/mus.24681. [PMID: 25899989]
  • P Fedorov, B Dzyuba, G Fedorova, R Grabic, J Cosson, M Rodina. Quantification of adenosine triphosphate, adenosine diphosphate, and creatine phosphate in sterlet spermatozoa during maturation. Journal of animal science. 2015 Nov; 93(11):5214-21. doi: 10.2527/jas.2015-9144. [PMID: 26641041]
  • I S Kucherenko, O O Soldatkin, F Lagarde, N Jaffrezic-Renault, S V Dzyadevych, A P Soldatkin. Determination of total creatine kinase activity in blood serum using an amperometric biosensor based on glucose oxidase and hexokinase. Talanta. 2015 Nov; 144(?):604-11. doi: 10.1016/j.talanta.2015.06.079. [PMID: 26452867]
  • Y Hasegawa, T Ijichi, Y Kurosawa, T Hamaoka, K Goto. Planned Overreaching and Subsequent Short-term Detraining Enhance Cycle Sprint Performance. International journal of sports medicine. 2015 Jul; 36(8):666-71. doi: 10.1055/s-0034-1390466. [PMID: 25958945]
  • José Luís Dores-Sousa, José Alberto Duarte, Vítor Seabra, Maria de Lourdes Bastos, Félix Carvalho, Vera Marisa Costa. The age factor for mitoxantrone's cardiotoxicity: multiple doses render the adult mouse heart more susceptible to injury. Toxicology. 2015 Mar; 329(?):106-19. doi: 10.1016/j.tox.2015.01.006. [PMID: 25582955]
  • Sulaiman R Hamarneh, Caitlin A Murphy, Cynthia W Shih, Walter Frontera, Martin Torriani, Javier E Irazoqui, Hideo Makimura. Relationship between serum IGF-1 and skeletal muscle IGF-1 mRNA expression to phosphocreatine recovery after exercise in obese men with reduced GH. The Journal of clinical endocrinology and metabolism. 2015 Feb; 100(2):617-25. doi: 10.1210/jc.2014-2711. [PMID: 25375982]
  • Tracy L Hellem, Young-Hoon Sung, Xian-Feng Shi, Marjorie A Pett, Gwen Latendresse, Jubel Morgan, Rebekah S Huber, Danielle Kuykendall, Kelly J Lundberg, Perry F Renshaw. Creatine as a Novel Treatment for Depression in Females Using Methamphetamine: A Pilot Study. Journal of dual diagnosis. 2015; 11(3-4):189-202. doi: 10.1080/15504263.2015.1100471. [PMID: 26457568]
  • Michael Macia, Emilie Pecchi, Christophe Vilmen, Martine Desrois, Carole Lan, Bernard Portha, Monique Bernard, David Bendahan, Benoît Giannesini. Insulin Resistance Is Not Associated with an Impaired Mitochondrial Function in Contracting Gastrocnemius Muscle of Goto-Kakizaki Diabetic Rats In Vivo. PloS one. 2015; 10(6):e0129579. doi: 10.1371/journal.pone.0129579. [PMID: 26057538]
  • Anni Vanhatalo, Andrew M Jones, James R Blackwell, Paul G Winyard, Jonathan Fulford. Dietary nitrate accelerates postexercise muscle metabolic recovery and O2 delivery in hypoxia. Journal of applied physiology (Bethesda, Md. : 1985). 2014 Dec; 117(12):1460-70. doi: 10.1152/japplphysiol.00096.2014. [PMID: 25301896]
  • Suzanna Maria Zick, Heather Zwickey, Lisa Wood, Bradley Foerster, Tohfa Khabir, Benjamin Wright, Eric Ichesco, Ananda Sen, Richard Edmund Harris. Preliminary differences in peripheral immune markers and brain metabolites between fatigued and non-fatigued breast cancer survivors: a pilot study. Brain imaging and behavior. 2014 Dec; 8(4):506-16. doi: 10.1007/s11682-013-9270-z. [PMID: 24222427]
  • A P Hayashi, M Y Solis, M T Sapienza, M C G Otaduy, A L de Sá Pinto, C A Silva, A M E Sallum, R M R Pereira, B Gualano. Efficacy and safety of creatine supplementation in childhood-onset systemic lupus erythematosus: a randomized, double-blind, placebo-controlled, crossover trial. Lupus. 2014 Dec; 23(14):1500-11. doi: 10.1177/0961203314546017. [PMID: 25135060]
  • Lei Xu, Chang-Yuan Wang, Li Lv, Ke-Xin Liu, Hui-Jun Sun, Guo-Zhu Han. Pharmacokinetics of phosphocreatine and its active metabolite creatine in the mouse plasma and myocardium. Pharmacological reports : PR. 2014 Oct; 66(5):908-14. doi: 10.1016/j.pharep.2014.05.013. [PMID: 25150000]
  • Hui Chen, Chao Gong, Cheng Ma, Xiaoni Zhang, Lishuang Xu, Caizhu Lin. Cardioprotective effects of phosphocreatine on myocardial cell ultrastructure and calcium-sensing receptor expression in the acute period following high level spinal cord injury. Molecular medicine reports. 2014 Jul; 10(1):560-6. doi: 10.3892/mmr.2014.2219. [PMID: 24820764]
  • Felismina T C Moreira, Rosa A F Dutra, João P Noronha, M Goreti F Sales. Novel sensory surface for creatine kinase electrochemical detection. Biosensors & bioelectronics. 2014 Jun; 56(?):217-22. doi: 10.1016/j.bios.2013.12.052. [PMID: 24508544]
  • Jun-mei Wang, Yang Chu, Wei Li, Xiang-yang Wang, Jia-hua Guo, Lu-lu Yan, Xiao-hui Ma, Ying-li Ma, Qi-hui Yin, Chang-xiao Liu. Simultaneous determination of creatine phosphate, creatine and 12 nucleotides in rat heart by LC-MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 May; 958(?):96-101. doi: 10.1016/j.jchromb.2014.03.008. [PMID: 24705537]
  • Kirsten Grimpo, Maximilian N Völker, Eva N Heppe, Steve Braun, Johannes T Heverhagen, Gerhard Heldmaier. Brown adipose tissue dynamics in wild-type and UCP1-knockout mice: in vivo insights with magnetic resonance. Journal of lipid research. 2014 Mar; 55(3):398-409. doi: 10.1194/jlr.m042895. [PMID: 24343897]
  • Robin P da Silva, Kathy Clow, John T Brosnan, Margaret E Brosnan. Synthesis of guanidinoacetate and creatine from amino acids by rat pancreas. The British journal of nutrition. 2014 Feb; 111(4):571-7. doi: 10.1017/s0007114513003012. [PMID: 24103317]
  • Thaís Tenório, Damiana C N Lopes, Andréa M Silva, Joanna Maria Ramos, Camilla D Buarque. Experimental and theoretical investigation of [Al(PCr)(H2O)] complex in aqueous solution. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2014 Jan; 118(?):260-70. doi: 10.1016/j.saa.2013.08.073. [PMID: 24051299]
  • Patrizia Garbati, Enrico Adriano, Annalisa Salis, Silvia Ravera, Gianluca Damonte, Enrico Millo, Maurizio Balestrino. Effects of amide creatine derivatives in brain hippocampal slices, and their possible usefulness for curing creatine transporter deficiency. Neurochemical research. 2014 Jan; 39(1):37-45. doi: 10.1007/s11064-013-1188-8. [PMID: 24213972]
  • Poonam Rana, Raman Kumar Marwaha, Pawan Kumar, Archana Narang, M Memita Devi, Rajendra Prasad Tripathi, Subash Khushu. Effect of vitamin D supplementation on muscle energy phospho-metabolites: a ³¹P magnetic resonance spectroscopy-based pilot study. Endocrine research. 2014; 39(4):152-6. doi: 10.3109/07435800.2013.865210. [PMID: 24679100]
  • Mauricio Peña Cunha, Maria D Martín-de-Saavedra, Alejandro Romero, Javier Egea, Fabiana K Ludka, Carla I Tasca, Marcelo Farina, Ana Lúcia S Rodrigues, Manuela G López. Both creatine and its product phosphocreatine reduce oxidative stress and afford neuroprotection in an in vitro Parkinson's model. ASN neuro. 2014; 6(6):. doi: 10.1177/1759091414554945. [PMID: 25424428]
  • Christiano R R Alves, Bianca M Santiago, Fernanda R Lima, Maria C G Otaduy, Ana Luisa Calich, Aline C C Tritto, Ana Lúcia de Sá Pinto, Hamilton Roschel, Cláudia C Leite, Fabiana B Benatti, Eloisa Bonfá, Bruno Gualano. Creatine supplementation in fibromyalgia: a randomized, double-blind, placebo-controlled trial. Arthritis care & research. 2013 Sep; 65(9):1449-59. doi: 10.1002/acr.22020. [PMID: 23554283]
  • Liyan Zhang, Jagdip S Jaswal, John R Ussher, Sowndramalingam Sankaralingam, Cory Wagg, Michael Zaugg, Gary D Lopaschuk. Cardiac insulin-resistance and decreased mitochondrial energy production precede the development of systolic heart failure after pressure-overload hypertrophy. Circulation. Heart failure. 2013 Sep; 6(5):1039-48. doi: 10.1161/circheartfailure.112.000228. [PMID: 23861485]
  • Akash Sinha, Kieren G Hollingsworth, Steve Ball, Tim Cheetham. Improving the vitamin D status of vitamin D deficient adults is associated with improved mitochondrial oxidative function in skeletal muscle. The Journal of clinical endocrinology and metabolism. 2013 Mar; 98(3):E509-13. doi: 10.1210/jc.2012-3592. [PMID: 23393184]
  • Luisa Perasso, Paolo Spallarossa, Carlo Gandolfo, Piero Ruggeri, Maurizio Balestrino. Therapeutic use of creatine in brain or heart ischemia: available data and future perspectives. Medicinal research reviews. 2013 Mar; 33(2):336-63. doi: 10.1002/med.20255. [PMID: 22135003]
  • Dhaval P Bhatt, Heidi M Houdek, John A Watt, Thad A Rosenberger. Acetate supplementation increases brain phosphocreatine and reduces AMP levels with no effect on mitochondrial biogenesis. Neurochemistry international. 2013 Feb; 62(3):296-305. doi: 10.1016/j.neuint.2013.01.004. [PMID: 23321384]
  • James Kelly, Jonathan Fulford, Anni Vanhatalo, Jamie R Blackwell, Olivia French, Stephen J Bailey, Mark Gilchrist, Paul G Winyard, Andrew M Jones. Effects of short-term dietary nitrate supplementation on blood pressure, O2 uptake kinetics, and muscle and cognitive function in older adults. American journal of physiology. Regulatory, integrative and comparative physiology. 2013 Jan; 304(2):R73-83. doi: 10.1152/ajpregu.00406.2012. [PMID: 23174856]
  • M Scharin Täng, B Redfors, M Lindbom, J Svensson, T Ramunddal, C Ohlsson, Y Shao, E Omerovic. Importance of circulating IGF-1 for normal cardiac morphology, function and post infarction remodeling. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. 2012 Dec; 22(6):206-11. doi: 10.1016/j.ghir.2012.09.002. [PMID: 23102937]
  • Anita M Rivera-Brown, Walter R Frontera. Principles of exercise physiology: responses to acute exercise and long-term adaptations to training. PM & R : the journal of injury, function, and rehabilitation. 2012 Nov; 4(11):797-804. doi: 10.1016/j.pmrj.2012.10.007. [PMID: 23174541]
  • Bagganahalli S Somashekar, Anita G Amin, Pratima Tripathi, Neil MacKinnon, Christopher D Rithner, Crystal A Shanley, Randall Basaraba, Marcela Henao-Tamayo, Midori Kato-Maeda, Ayyalusamy Ramamoorthy, Ian M Orme, Diane J Ordway, Delphi Chatterjee. Metabolomic signatures in guinea pigs infected with epidemic-associated W-Beijing strains of Mycobacterium tuberculosis. Journal of proteome research. 2012 Oct; 11(10):4873-84. doi: 10.1021/pr300345x. [PMID: 22873951]
  • I B Krylova, V V Bulion, E N Selina, G D Mironova, N S Sapronov. Effect of uridine on energy metabolism, LPO, and antioxidant system in the myocardium under conditions of acute coronary insufficiency. Bulletin of experimental biology and medicine. 2012 Sep; 153(5):644-6. doi: 10.1007/s10517-012-1787-4. [PMID: 23113246]
  • Zsolt Sarszegi, Eszter Bognar, Balazs Gaszner, Attila Kónyi, Ferenc Gallyas, Balazs Sumegi, Zoltan Berente. BGP-15, a PARP-inhibitor, prevents imatinib-induced cardiotoxicity by activating Akt and suppressing JNK and p38 MAP kinases. Molecular and cellular biochemistry. 2012 Jun; 365(1-2):129-37. doi: 10.1007/s11010-012-1252-8. [PMID: 22350755]
  • Po Miao, Bing Sun, Xing Feng. [Treatment of myocardial damage with creatine phosphate following neonatal asphyxia: a meta-analysis]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. 2012 Mar; 14(3):172-6. doi: . [PMID: 22433401]
  • Alison Sleigh, Anna Stears, Kerrie Thackray, Laura Watson, Alessandra Gambineri, Sath Nag, V Irene Campi, Nadia Schoenmakers, Soren Brage, T Adrian Carpenter, Peter R Murgatroyd, Stephen O'Rahilly, Graham J Kemp, David B Savage. Mitochondrial oxidative phosphorylation is impaired in patients with congenital lipodystrophy. The Journal of clinical endocrinology and metabolism. 2012 Mar; 97(3):E438-42. doi: 10.1210/jc.2011-2587. [PMID: 22238385]
  • V A Kosinets. [Metabolic correction of the lipid-transport system in experimental diffuse purulent peritonitis]. Vestnik khirurgii imeni I. I. Grekova. 2012; 171(3):92-6. doi: ". [PMID: 22880442]
  • V A Kosinets, S S Osochuk, N N Iarotskaia. [Correction of protein-lipid composition in liver mitochondria during experimental widespread purulent peritonitis]. Eksperimental'naia i klinicheskaia farmakologiia. 2012; 75(3):31-4. doi: ". [PMID: 22679751]
  • Charlotte Brøns, Stine Jacobsen, Natalie Hiscock, Andrew White, Emma Nilsson, David Dunger, Arne Astrup, Bjørn Quistorff, Allan Vaag. Effects of high-fat overfeeding on mitochondrial function, glucose and fat metabolism, and adipokine levels in low-birth-weight subjects. American journal of physiology. Endocrinology and metabolism. 2012 Jan; 302(1):E43-51. doi: 10.1152/ajpendo.00095.2011. [PMID: 21917634]
  • V A Kosinets, N N Iarotskaia. [Free-radical oxidation in liver during experimental widespread purulent peritonitis]. Eksperimental'naia i klinicheskaia farmakologiia. 2012; 75(10):37-41. doi: ". [PMID: 23240157]
  • V A Kosinets, S S Osochuk, N N Iarotskaia. [The correction of the mitochondrial lipid spectre in liver by the experimental peritoniti]. Khirurgiia. 2012; ?(2):60-3. doi: . [PMID: 22678477]
  • Malgorzata Tokarska-Schlattner, Raquel F Epand, Flurina Meiler, Giorgia Zandomeneghi, Dietbert Neumann, Hans R Widmer, Beat H Meier, Richard M Epand, Valdur Saks, Theo Wallimann, Uwe Schlattner. Phosphocreatine interacts with phospholipids, affects membrane properties and exerts membrane-protective effects. PloS one. 2012; 7(8):e43178. doi: 10.1371/journal.pone.0043178. [PMID: 22912820]
  • Mabel Buelna-Chontal, Francisco Correa, Sauri Hernández-Reséndiz, Cecilia Zazueta, José Pedraza-Chaverri. Protective effect of α-mangostin on cardiac reperfusion damage by attenuation of oxidative stress. Journal of medicinal food. 2011 Nov; 14(11):1370-4. doi: 10.1089/jmf.2010.0238. [PMID: 21942497]
  • Heng Xi, Guozhu Han, Li Lü, Di Zhang. [Simultaneous determination of exogenous phosphocreatine and its metabolite creatine in rabbit plasma using ion-pair reversed-phase high performance liquid chromatography]. Se pu = Chinese journal of chromatography. 2011 Oct; 29(10):1000-4. doi: NULL. [PMID: 22268357]
  • Takashi Yokota, Shintaro Kinugawa, Koichi Okita, Kagami Hirabayashi, Tadashi Suga, Masaaki Hattori, Yoshinao Nakagawa, Noriko Oyama-Manabe, Hiroki Shirato, Hiroyuki Tsutsui. Lower aerobic capacity was associated with abnormal intramuscular energetics in patients with metabolic syndrome. Hypertension research : official journal of the Japanese Society of Hypertension. 2011 Sep; 34(9):1029-34. doi: 10.1038/hr.2011.78. [PMID: 21753774]
  • Roger M Beadle, Lynne K Williams, Khaild Abozguia, Kiran Patel, Francisco Leyva Leon, Zaheer Yousef, Anton Wagenmakers, Michael P Frenneaux. Metabolic manipulation in chronic heart failure: study protocol for a randomised controlled trial. Trials. 2011 Jun; 12(?):140. doi: 10.1186/1745-6215-12-140. [PMID: 21645332]
  • Alison Sleigh, Philippa Raymond-Barker, Kerrie Thackray, David Porter, Mensud Hatunic, Alessandra Vottero, Christine Burren, Catherine Mitchell, Martin McIntyre, Soren Brage, T Adrian Carpenter, Peter R Murgatroyd, Kevin M Brindle, Graham J Kemp, Stephen O'Rahilly, Robert K Semple, David B Savage. Mitochondrial dysfunction in patients with primary congenital insulin resistance. The Journal of clinical investigation. 2011 Jun; 121(6):2457-61. doi: 10.1172/jci46405. [PMID: 21555852]
  • Bruno Gualano, Vitor DE Salles Painneli, Hamilton Roschel, Guilherme Giannini Artioli, Manoel Neves, Ana Lúcia De Sá Pinto, Maria Elizabeth Rossi Da Silva, Maria Rosária Cunha, Maria Concepción García Otaduy, Claudia Da Costa Leite, Júlio César Ferreira, Rosa Maria Pereira, Patrícia Chakur Brum, Eloisa Bonfá, Antonio Herbert Lancha. Creatine in type 2 diabetes: a randomized, double-blind, placebo-controlled trial. Medicine and science in sports and exercise. 2011 May; 43(5):770-8. doi: 10.1249/mss.0b013e3181fcee7d. [PMID: 20881878]
  • Cameron J Holloway, Lowri E Cochlin, Yaso Emmanuel, Andrew Murray, Ion Codreanu, Lindsay M Edwards, Cezary Szmigielski, Damian J Tyler, Nicholas S Knight, Brian K Saxby, Bridget Lambert, Campbell Thompson, Stefan Neubauer, Kieran Clarke. A high-fat diet impairs cardiac high-energy phosphate metabolism and cognitive function in healthy human subjects. The American journal of clinical nutrition. 2011 Apr; 93(4):748-55. doi: 10.3945/ajcn.110.002758. [PMID: 21270386]
  • Dragana Lavrnic, Marko Dakovic, Stojan Peric, Vidosava Rakocevic-Stojanovic, Ivana Basta, Ivan Marjanovic, Tatjana Stosic-Opincal, Slobodan Lavrnic. Proton magnetic resonance spectroscopy of the intrinsic tongue muscles in patients with myasthenia gravis with different autoantibodies. Journal of the neurological sciences. 2011 Mar; 302(1-2):25-8. doi: 10.1016/j.jns.2010.12.009. [PMID: 21236447]
  • Hideo Makimura, Takara L Stanley, Noelle Sun, Jean M Connelly, Linda C Hemphill, Mirko I Hrovat, David M Systrom, Steven K Grinspoon. Increased skeletal muscle phosphocreatine recovery after sub-maximal exercise is associated with increased carotid intima-media thickness. Atherosclerosis. 2011 Mar; 215(1):214-7. doi: 10.1016/j.atherosclerosis.2010.11.037. [PMID: 21185022]
  • Tarek K Motawi, Hebatallah A Darwish, Azza M Abd El Tawab. Effects of caffeic acid phenethyl ester on endotoxin-induced cardiac stress in rats: a possible mechanism of protection. Journal of biochemical and molecular toxicology. 2011 Mar; 25(2):84-94. doi: 10.1002/jbt.20362. [PMID: 21472898]
  • Jeeyoun Jung, Minhwa Park, Hye Jin Park, Sun Bo Shim, Yang Ha Cho, Jinho Kim, Ho-Sub Lee, Do Hyun Ryu, Donwoong Choi, Geum-Sook Hwang. ¹H NMR-based metabolic profiling of naproxen-induced toxicity in rats. Toxicology letters. 2011 Jan; 200(1-2):1-7. doi: 10.1016/j.toxlet.2010.09.020. [PMID: 20932884]
  • Ling-Li Zou, Qiu-Sha Li, Guo-Zhu Han, Li Lü, Heng Xi, Jian-Hua Li. [Pharmacokinetics and metabolic disposition of exogenous phosphocreatine in rats]. Yao xue xue bao = Acta pharmaceutica Sinica. 2011 Jan; 46(1):75-80. doi: NULL. [PMID: 21465812]
  • Finian M O'Brien, Lisa Page, Ruth L O'Gorman, Patrick Bolton, Ajay Sharma, Gillian Baird, Eileen Daly, Brian Hallahan, Ronán M Conroy, Catherine Foy, Sarah Curran, Dene Robertson, Kieran C Murphy, Declan G M Murphy. Maturation of limbic regions in Asperger syndrome: a preliminary study using proton magnetic resonance spectroscopy and structural magnetic resonance imaging. Psychiatry research. 2010 Nov; 184(2):77-85. doi: 10.1016/j.pscychresns.2010.08.007. [PMID: 20952166]
  • A Brehm, M Krssák, A I Schmid, P Nowotny, W Waldhäusl, M Roden. Acute elevation of plasma lipids does not affect ATP synthesis in human skeletal muscle. American journal of physiology. Endocrinology and metabolism. 2010 Jul; 299(1):E33-8. doi: 10.1152/ajpendo.00756.2009. [PMID: 20442322]
  • Stephen J Bailey, Jonathan Fulford, Anni Vanhatalo, Paul G Winyard, Jamie R Blackwell, Fred J DiMenna, Daryl P Wilkerson, Nigel Benjamin, Andrew M Jones. Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans. Journal of applied physiology (Bethesda, Md. : 1985). 2010 Jul; 109(1):135-48. doi: 10.1152/japplphysiol.00046.2010. [PMID: 20466802]
  • Nicholas P L Tuckey, Malcolm E Forster, Steven P Gieseg. Effects of rested harvesting on muscle metabolite concentrations and K-values in Chinook salmon (Oncorhynchus tshawytscha) fillets during storage at 15 degrees C. Journal of food science. 2010 Jun; 75(5):C459-64. doi: 10.1111/j.1750-3841.2010.01648.x. [PMID: 20629868]
  • Dick Brown, Gaétan Chevalier, Michael Hill. Pilot study on the effect of grounding on delayed-onset muscle soreness. Journal of alternative and complementary medicine (New York, N.Y.). 2010 Mar; 16(3):265-73. doi: 10.1089/acm.2009.0399. [PMID: 20192911]
  • Marc-André Weber, Wulf Hildebrandt, Leif Schröder, Ralf Kinscherf, Martin Krix, Peter Bachert, Stefan Delorme, Marco Essig, Hans-Ulrich Kauczor, Holger Krakowski-Roosen. Concentric resistance training increases muscle strength without affecting microcirculation. European journal of radiology. 2010 Mar; 73(3):614-21. doi: 10.1016/j.ejrad.2008.12.002. [PMID: 19144482]
  • Tatsuro Egawa, Taku Hamada, Naoko Kameda, Kouhei Karaike, Xiao Ma, Shinya Masuda, Nobumasa Iwanaka, Tatsuya Hayashi. Caffeine acutely activates 5'adenosine monophosphate-activated protein kinase and increases insulin-independent glucose transport in rat skeletal muscles. Metabolism: clinical and experimental. 2009 Nov; 58(11):1609-17. doi: 10.1016/j.metabol.2009.05.013. [PMID: 19608206]
  • Thanh Dinh, John Doupis, Thomas E Lyons, Sarada Kuchibhotla, Walker Julliard, Charalambos Gnardellis, Barry I Rosenblum, Xiaoen Wang, John M Giurini, Robert L Greenman, Aristidis Veves. Foot muscle energy reserves in diabetic patients without and with clinical peripheral neuropathy. Diabetes care. 2009 Aug; 32(8):1521-4. doi: 10.2337/dc09-0536. [PMID: 19509013]
  • Charlotte Brøns, Christine B Jensen, Heidi Storgaard, Natalie J Hiscock, Andrew White, Julie S Appel, Stine Jacobsen, Emma Nilsson, Claus M Larsen, Arne Astrup, Bjørn Quistorff, Allan Vaag. Impact of short-term high-fat feeding on glucose and insulin metabolism in young healthy men. The Journal of physiology. 2009 May; 587(Pt 10):2387-97. doi: 10.1113/jphysiol.2009.169078. [PMID: 19332493]