nitrendipine (BioDeep_00000399075)

Main id: BioDeep_00000002105

 

natural product


代谢物信息卡片


nitrendipine

化学式: C18H20N2O6 (360.1321)
中文名称: 尼群地平
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=CC(=C1)[N+]([O-])=O)C2C(=C(NC(=C2C(=O)OC)C)C)C(=O)OCC
InChI: InChI=1S/C18H20N2O6/c1-5-26-18(22)15-11(3)19-10(2)14(17(21)25-4)16(15)12-7-6-8-13(9-12)20(23)24/h6-9,16,19H,5H2,1-4H3

描述信息

C - Cardiovascular system > C08 - Calcium channel blockers > C08C - Selective calcium channel blockers with mainly vascular effects > C08CA - Dihydropyridine derivatives
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker

同义名列表

2 个代谢物同义名

nitrendipine; Nitrendipine



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ABCB1, ACE, ALB, AXIN2, CYP3A4, EDN1, PLA2G12A, XDH
Peripheral membrane protein 1 CYP1B1
Endoplasmic reticulum membrane 2 CYP1B1, CYP3A4
Nucleus 3 ALB, AXIN2, PLCZ1
cytosol 5 ALB, AXIN2, PLCZ1, PRKCQ, XDH
centrosome 2 ALB, AXIN2
nucleoplasm 3 ATP2B1, CD2, PLCZ1
Cell membrane 5 ABCB1, ACE, AGTR1, ATP2B1, CD2
Multi-pass membrane protein 4 ABCB1, AGTR1, ATP2B1, CACNA1I
Synapse 1 ATP2B1
cell surface 2 ABCB1, CD2
glutamatergic synapse 1 ATP2B1
Golgi apparatus 2 ALB, CD2
Golgi membrane 1 INS
presynaptic membrane 1 ATP2B1
Lysosome 1 ACE
endosome 1 ACE
plasma membrane 10 ABCB1, ACE, AGTR1, ATP2B1, AXIN2, CACNA1I, CD2, F2, PRKCQ, REN
synaptic vesicle membrane 1 ATP2B1
Membrane 8 ABCB1, ACE, AGTR1, ATP2B1, CACNA1I, CYP1B1, CYP3A4, REN
apical plasma membrane 1 ABCB1
basolateral plasma membrane 1 ATP2B1
extracellular exosome 5 ABCB1, ACE, ALB, ATP2B1, F2
endoplasmic reticulum 1 ALB
extracellular space 8 ACE, ALB, EDN1, F2, INS, PTH, REN, XDH
perinuclear region of cytoplasm 1 PLCZ1
mitochondrion 1 CYP1B1
protein-containing complex 2 ALB, CD2
intracellular membrane-bounded organelle 3 ATP2B1, CYP1B1, CYP3A4
Microsome membrane 2 CYP1B1, CYP3A4
pronucleus 1 PLCZ1
Single-pass type I membrane protein 2 ACE, CD2
Secreted 7 ACE, ALB, EDN1, F2, INS, PLA2G12A, REN
extracellular region 9 ACE, ALB, CD2, EDN1, F2, INS, PLA2G12A, PTH, REN
cytoplasmic side of plasma membrane 1 CD2
basal part of cell 1 EDN1
anchoring junction 1 ALB
centriolar satellite 1 PRKCQ
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
external side of plasma membrane 2 ACE, CD2
beta-catenin destruction complex 1 AXIN2
nucleolus 1 PLCZ1
apical part of cell 1 REN
cell-cell junction 1 CD2
Apical cell membrane 1 ABCB1
Cytoplasm, perinuclear region 1 PLCZ1
Peroxisome 1 XDH
sarcoplasmic reticulum 1 XDH
collagen-containing extracellular matrix 1 F2
lateral plasma membrane 1 ATP2B1
ciliary basal body 1 ALB
cell projection 1 ATP2B1
centriole 1 ALB
brush border membrane 1 ACE
spindle pole 1 ALB
blood microparticle 2 ALB, F2
sperm midpiece 1 ACE
Basolateral cell membrane 1 ATP2B1
endosome lumen 1 INS
Presynaptic cell membrane 1 ATP2B1
basal plasma membrane 1 ACE
secretory granule lumen 1 INS
Golgi lumen 2 F2, INS
endoplasmic reticulum lumen 3 ALB, F2, INS
platelet alpha granule lumen 1 ALB
voltage-gated calcium channel complex 1 CACNA1I
transport vesicle 2 EDN1, INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 2 ATP2B1, PRKCQ
aggresome 1 PRKCQ
external side of apical plasma membrane 1 ABCB1
hemoglobin complex 1 HBA1
rough endoplasmic reticulum lumen 1 EDN1
sperm head 1 PLCZ1
Weibel-Palade body 1 EDN1
photoreceptor ribbon synapse 1 ATP2B1
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
ciliary transition fiber 1 ALB


文献列表

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  • Mohammad Abdul-Azim Mohammad, Marianne Alphonse Mahrouse, Enas Abdel Hakeem Amer, Nouran Saleh Elharati. Validated LC-MS/MS method for the simultaneous determination of enalapril maleate, nitrendipine, hydrochlorothiazide, and their major metabolites in human plasma. Biomedical chromatography : BMC. 2020 Dec; 34(12):e4955. doi: 10.1002/bmc.4955. [PMID: 32706446]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Praveen Kumar Gaur, Shikha Mishra, Suresh Purohit. Nanovesicles of nitrendipine with lipid complex for transdermal delivery: pharmacokinetic and pharmacodynamic studies. Artificial cells, nanomedicine, and biotechnology. 2016 Nov; 44(7):1684-93. doi: 10.3109/21691401.2015.1080170. [PMID: 26375758]
  • Swathi Voruganti, Shravan Kumar Yamsani, Madhusudan Rao Yamsani. Effect of silibinin on the pharmacokinetics of nitrendipine in rabbits. European journal of drug metabolism and pharmacokinetics. 2014 Dec; 39(4):277-81. doi: 10.1007/s13318-013-0156-7. [PMID: 24092617]
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  • Swathi Voruganti, Shravan Kumar Yamsani, Shiva Kumar Ravula, Ramesh Gannu, Madhusudan Rao Yamsani. Effect of pomegranate juice on intestinal transport and pharmacokinetics of nitrendipine in rats. Phytotherapy research : PTR. 2012 Aug; 26(8):1240-5. doi: 10.1002/ptr.3704. [PMID: 22275232]
  • Swathi Voruganti, Kishore Rapolu, Santoshkumar Tota, Shravan Kumar Yamsani, Madhusudan Rao Yamsani. Effect of pomegranate juice on the pharmacokinetics of nitrendipine in rabbits. European journal of drug metabolism and pharmacokinetics. 2012 Jun; 37(2):77-81. doi: 10.1007/s13318-011-0075-4. [PMID: 22101410]
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  • Ashu Mittal, Udai Vir Singh Sara, Asgar Ali, Mohammed Aqil. The effect of penetration enhancers on permeation kinetics of nitrendipine in two different skin models. Biological & pharmaceutical bulletin. 2008 Sep; 31(9):1766-72. doi: 10.1248/bpb.31.1766. [PMID: 18758074]
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  • Ying Liu, Feng-Guo Xul, Zun-Jian Zhang, Rui Song, Yuan Tian, Yun Chen. Quantitative determination of nitrendipine in human plasma using high-performance liquid chromatography-mass spectrometry. Arzneimittel-Forschung. 2008; 58(3):111-6. doi: 10.1055/s-0031-1296478. [PMID: 18488806]
  • Zheng-hai Long, Zai-chang Yang, Xiong-zhi Yang. [Study on skin toxicology and penetration enhancement of skin absorption of volatile oil extracted from tender branchers of Camellia oleifera]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2007 Sep; 32(17):1780-3. doi: ". [PMID: 17993001]
  • Kavi J Littlewood, Wolfgang Greiner, Dominique Baum, York Zoellner. Adjunctive treatment with moxonidine versus nitrendipine for hypertensive patients with advanced renal failure: a cost-effectiveness analysis. BMC nephrology. 2007 Jul; 8(?):9. doi: 10.1186/1471-2369-8-9. [PMID: 17645811]
  • Venishetty Vinay Kumar, Durairaj Chandrasekar, Sistla Ramakrishna, Veerabrahma Kishan, Yamsani Madhusudan Rao, Prakash Vamanrao Diwan. Development and evaluation of nitrendipine loaded solid lipid nanoparticles: influence of wax and glyceride lipids on plasma pharmacokinetics. International journal of pharmaceutics. 2007 Apr; 335(1-2):167-175. doi: 10.1016/j.ijpharm.2006.11.004. [PMID: 17161566]
  • Vinay Kumar Venishetty, Chandrasekar Durairaj, Ramakrishna Sistla, Madhusudhan Rao Yamsani, Prakash V Diwan. Development and validation of a reversed-phase HPLC method for determination of nitrendipine in rat plasma: application to pharmacokinetic studies. Biomedical chromatography : BMC. 2007 Apr; 21(4):363-8. doi: 10.1002/bmc.761. [PMID: 17236247]
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