Nitrendipine (BioDeep_00000002105)

 

Secondary id: BioDeep_00000399075

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester

化学式: C18H20N2O6 (360.13213)
中文名称: 尼群地平
谱图信息: 最多检出来源 Homo sapiens(blood) 47.11%

分子结构信息

SMILES: CCOC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OC)C
InChI: InChI=1S/C18H20N2O6/c1-5-26-18(22)15-11(3)19-10(2)14(17(21)25-4)16(15)12-7-6-8-13(9-12)20(23)24/h6-9,16,19H,5H2,1-4H3

描述信息

Nitrendipine is only found in individuals that have used or taken this drug. It is a calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive. [PubChem]By deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, Nitrendipine inhibits the influx of extracellular calcium across the myocardial and vascular smooth muscle cell membranes The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.
C - Cardiovascular system > C08 - Calcium channel blockers > C08C - Selective calcium channel blockers with mainly vascular effects > C08CA - Dihydropyridine derivatives
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D000077264 - Calcium-Regulating Hormones and Agents
CONFIDENCE standard compound; INTERNAL_ID 8498
CONFIDENCE standard compound; INTERNAL_ID 2309
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker

同义名列表

145 个代谢物同义名

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester; 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate ethyl methyl ester; 3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; Prevision y salud brand OF nitrendipine; CT Arzneimittel brand OF nitrendipine; CT-Arzneimittel brand OF nitrendipine; Lichtenstein brand OF nitrendipine; Nitrendipine CT-arzneimittel brand; Lindopharm brand OF nitrendipine; Ratiopharm brand OF nitrendipine; KSK Pharma brand OF nitrendipine; Merck dura brand OF nitrendipine; Stadapharm brand OF nitrendipine; Betapharm brand OF nitrendipine; Jenapharm brand OF nitrendipine; Azupharma brand OF nitrendipine; Nitrendipine lichtenstein brand; Almirall brand OF nitrendipine; Apogepha brand OF nitrendipine; Alpharma brand OF nitrendipine; Docpharm brand OF nitrendipine; Nitrendipine ratiopharm brand; Nitrendipine lindopharm brand; Heumann brand OF nitrendipine; Q-Pharm brand OF nitrendipine; Nitrendipine stadapharm brand; Schwarz brand OF nitrendipine; Nitrendipine azupharma brand; Basics brand OF nitrendipine; Biomed brand OF nitrendipine; Wörwag brand OF nitrendipine; Dexcel brand OF nitrendipine; Nitrendipine jenapharm brand; Nitrendipine betapharm brand; Bayvit brand OF nitrendipine; Nitrendipine docpharm brand; Nitrendipine almirall brand; Bayer brand OF nitrendipine; Nitrendipine apogepha brand; Elfar brand OF nitrendipine; Hexal brand OF nitrendipine; Corax brand OF nitrendipine; Aliud brand OF nitrendipine; Nitrendipine alpharma brand; Juta brand OF nitrendipine; Nitrendipine Q-pharm brand; Acis brand OF nitrendipine; Seid brand OF nitrendipine; Nitrendipine heumann brand; Nitrendipine schwarz brand; Elan brand OF nitrendipine; TAD brand OF nitrendipine; Nitrendipine bayvit brand; Nitrendipine biomed brand; AbZ brand OF nitrendipine; Nitrendipine wörwag brand; Nitrendipine dexcel brand; Nitrendipine basics brand; Nitrendipine aliud brand; BC Brand OF nitrendipine; Nitrendipine corax brand; Ratiopharm, nitrendipino; 1a Brand OF nitrendipine; Nitrendipine elfar brand; Nitrendipine hexal brand; Nitrendipine bayer brand; Nitrendipino ratiopharm; Nitrendipine juta brand; Nitrendipine elan brand; Nitrendipine acis brand; Nitrendipine seid brand; Nitrendipin-ratiopharm; Jenapharm, nitrendipin; Nitrendipine tad brand; Nitrendipin ratiopharm; Nitrendipine abz brand; Nitrendipine BC brand; Nitrendipine 1a brand; Nitrendipin jenapharm; Apogepha, nitrendipin; Nitrendipinratiopharm; Bayvit, nitrendipino; Nitrendipin apogepha; Heumann, nitrendipin; Biochemie, nitrendi; Von CT, nitrendipin; Nitrendipin heumann; Basics, nitrendipin; Nitrendipino bayvit; CT, Nitrendipin von; Nitrendipin basics; Nitrendi biochemie; Lindo, nitrendipin; Nitrendipin von CT; Stada, nitrendipin; Nitrendipin corax; beta, Nitrendipin; Nitrendipin-corax; Nitrendipin lindo; Pharma, nitren 1a; 1a Pharma, nitren; Nitrendipin stada; Atid, nitrendipin; Nitrendipin atid; Nitren 1a pharma; Nitrendipincorax; Nitrendipin beta; AL, nitrendipin; Nitrendipin al; Nitrendimerck; Nitrendipinum; KSK, Nitrend; Nitrendipino; nitrendipine; Acis, nitren; Lich, nitren; Nitren lich; Nitrend KSK; Nitren acis; Tensogradal; Nitre puren; Nitrendidoc; Nitre-puren; Nitrendepat; Nitrendipin; Vastensium; Nitregamma; BAY e 5009; AbZ, nitre; Nitrepress; Bylotensin; NitrePuren; Bayotensin; Trendinol; Jutapress; Nitrensal; Baypresol; Nitre abz; Baypress; Balminil; Gericin; Niprina; Deiten; Nidrel; Nitrendipine



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Mohammad Abdul-Azim Mohammad, Marianne Alphonse Mahrouse, Enas Abdel Hakeem Amer, Nouran Saleh Elharati. Validated LC-MS/MS method for the simultaneous determination of enalapril maleate, nitrendipine, hydrochlorothiazide, and their major metabolites in human plasma. Biomedical chromatography : BMC. 2020 Dec; 34(12):e4955. doi: 10.1002/bmc.4955. [PMID: 32706446]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Praveen Kumar Gaur, Shikha Mishra, Suresh Purohit. Nanovesicles of nitrendipine with lipid complex for transdermal delivery: pharmacokinetic and pharmacodynamic studies. Artificial cells, nanomedicine, and biotechnology. 2016 Nov; 44(7):1684-93. doi: 10.3109/21691401.2015.1080170. [PMID: 26375758]
  • Swathi Voruganti, Shravan Kumar Yamsani, Madhusudan Rao Yamsani. Effect of silibinin on the pharmacokinetics of nitrendipine in rabbits. European journal of drug metabolism and pharmacokinetics. 2014 Dec; 39(4):277-81. doi: 10.1007/s13318-013-0156-7. [PMID: 24092617]
  • Chia-Wen Hsu, Jinghua Zhao, Ruili Huang, Jui-Hua Hsieh, Jon Hamm, Xiaoqing Chang, Keith Houck, Menghang Xia. Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor. Scientific reports. 2014 Sep; 4(?):6437. doi: 10.1038/srep06437. [PMID: 25257666]
  • I N Iakovenko, V V Zhirnov, O P Kozachenko, O V Shablykin, V S Brovarets'. [Participation of proteinkinase CK2 in regulation of human erythrocytes plasma membrane redox system activity: relative contribution of ca(2+)-dependent and ca(2+)-independent mechanisms of its activation]. Ukrains'kyi biokhimichnyi zhurnal (1999 ). 2012 Sep; 84(5):55-61. doi: . [PMID: 23342635]
  • Swathi Voruganti, Shravan Kumar Yamsani, Shiva Kumar Ravula, Ramesh Gannu, Madhusudan Rao Yamsani. Effect of pomegranate juice on intestinal transport and pharmacokinetics of nitrendipine in rats. Phytotherapy research : PTR. 2012 Aug; 26(8):1240-5. doi: 10.1002/ptr.3704. [PMID: 22275232]
  • Swathi Voruganti, Kishore Rapolu, Santoshkumar Tota, Shravan Kumar Yamsani, Madhusudan Rao Yamsani. Effect of pomegranate juice on the pharmacokinetics of nitrendipine in rabbits. European journal of drug metabolism and pharmacokinetics. 2012 Jun; 37(2):77-81. doi: 10.1007/s13318-011-0075-4. [PMID: 22101410]
  • Anaïs Grall, Eric Guaguère, Sandrine Planchais, Susanne Grond, Emmanuelle Bourrat, Ingrid Hausser, Christophe Hitte, Matthieu Le Gallo, Céline Derbois, Gwang-Jin Kim, Laëtitia Lagoutte, Frédérique Degorce-Rubiales, Franz P W Radner, Anne Thomas, Sébastien Küry, Emmanuel Bensignor, Jacques Fontaine, Didier Pin, Robert Zimmermann, Rudolf Zechner, Mark Lathrop, Francis Galibert, Catherine André, Judith Fischer. PNPLA1 mutations cause autosomal recessive congenital ichthyosis in golden retriever dogs and humans. Nature genetics. 2012 Jan; 44(2):140-7. doi: 10.1038/ng.1056. [PMID: 22246504]
  • Xiaowei Shi, Man Liu, Mengmeng Sun, Qiao Wang, Weina Liu, Deying Cao. Development of a LC-ESI-MS3 method for determination of nitrendipine in human plasma. Journal of pharmaceutical and biomedical analysis. 2011 Dec; 56(5):1101-5. doi: 10.1016/j.jpba.2011.07.043. [PMID: 21885229]
  • Dewei Shang, Xipei Wang, Xiutai Zhao, Fengming Huang, Ganzhong Tian, Wei Lu, Tianyan Zhou. Simultaneous determination of nitrendipine and hydrochlorothiazide in spontaneously hypertensive rat plasma using HPLC with on-line solid-phase extraction. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 Nov; 879(30):3459-64. doi: 10.1016/j.jchromb.2011.09.025. [PMID: 21968134]
  • Yan Zhang, YanJun Cao, QunLi Wang, Lei Zheng, Jie Zhang, LangChong He. A potential calcium antagonist and its antihypertensive effects. Fitoterapia. 2011 Oct; 82(7):988-96. doi: 10.1016/j.fitote.2011.05.016. [PMID: 21679750]
  • Göknur Aktay, Memet Hanifi Emre, Alaadin Polat. Influence of dihydropyridine calcium antagonist nitrendipine on benzo(a)pyrene-induced oxidative stress. Archives of pharmacal research. 2011 Jul; 34(7):1171-5. doi: 10.1007/s12272-011-0715-x. [PMID: 21811924]
  • K Manjunath, V Venkateswarlu, A Hussain. Preparation and characterization of nitrendipine solid lipid nanoparticles. Die Pharmazie. 2011 Mar; 66(3):178-86. doi: . [PMID: 21553647]
  • Yanhua Liu, Zhiyuan Wang, Jin Sun, Yongjun Wang, Zhonggui He. Ultra-performance liquid chromatography-tandem mass spectrometry method for the determination of nitrendipine in dog plasma and its application to a pharmacokinetic study of a solid self-emulsifying pellet formulation. Arzneimittel-Forschung. 2011; 61(12):674-80. doi: 10.1055/s-0031-1300586. [PMID: 22282953]
  • L Rodat-Despoix, V Aires, T Ducret, R Marthan, J-P Savineau, E Rousseau, C Guibert. Signalling pathways involved in the contractile response to 5-HT in the human pulmonary artery. The European respiratory journal. 2009 Dec; 34(6):1338-47. doi: 10.1183/09031936.00143808. [PMID: 19541711]
  • Jin Li, Qi-Xiong Li, Xian-Fei Xie, Ying Ao, Chao-Rong Tie, Ren-Jie Song. Differential roles of dihydropyridine calcium antagonist nifedipine, nitrendipine and amlodipine on gentamicin-induced renal tubular toxicity in rats. European journal of pharmacology. 2009 Oct; 620(1-3):97-104. doi: 10.1016/j.ejphar.2009.08.021. [PMID: 19698708]
  • Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance. Journal of medicinal chemistry. 2009 Aug; 52(15):4844-52. doi: 10.1021/jm900403j. [PMID: 19445515]
  • Greg L Plosker. Eprosartan: a review of its use in hypertension. Drugs. 2009; 69(17):2477-99. doi: 10.2165/11203980-000000000-00000. [PMID: 19911859]
  • Kesavan Bhaskar, Chinnala Krishna Mohan, Meka Lingam, Somagoni Jagan Mohan, Vobalaboina Venkateswarlu, Yamsani Madhusudan Rao, Kesavan Bhaskar, Jayaraman Anbu, Velayudam Ravichandran. Development of SLN and NLC enriched hydrogels for transdermal delivery of nitrendipine: in vitro and in vivo characteristics. Drug development and industrial pharmacy. 2009 Jan; 35(1):98-113. doi: 10.1080/03639040802192822. [PMID: 18665979]
  • Ashu Mittal, Udai Vir Singh Sara, Asgar Ali, Mohammed Aqil. The effect of penetration enhancers on permeation kinetics of nitrendipine in two different skin models. Biological & pharmaceutical bulletin. 2008 Sep; 31(9):1766-72. doi: 10.1248/bpb.31.1766. [PMID: 18758074]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • Kesavan Bhaskar, Chinnala Krishna Mohan, Meka Lingam, Veerareddy Prabhakar Reddy, Vobalaboina Venkateswarlu, Yamsani Madhusudan Rao. Development of nitrendipine controlled release formulations based on SLN and NLC for topical delivery: in vitro and ex vivo characterization. Drug development and industrial pharmacy. 2008 Jul; 34(7):719-25. doi: 10.1080/03639040701842485. [PMID: 18612912]
  • A Armenia, Munavvar Abdul Sattar, Nor Azizan Abdullah, Md Abdul Hye Khan, Edward James Johns. Functional subtypes of renal alpha1-adrenoceptor in diabetic and non-diabetic 2K1C Goldblatt renovascular hypertension. Acta pharmacologica Sinica. 2008 May; 29(5):564-72. doi: 10.1111/j.1745-7254.2008.00788.x. [PMID: 18430364]
  • Pedro J Gomez-Pinilla, Pedro J Camello, María J Pozo. Protective effect of melatonin on Ca2+ homeostasis and contractility in acute cholecystitis. Journal of pineal research. 2008 Apr; 44(3):250-60. doi: 10.1111/j.1600-079x.2007.00520.x. [PMID: 18339120]
  • M A Sattar, N A Abdullah, Md A H Khan, E J Johns. Alpha1A- and alpha1D-adrenoceptors are the major functional subtypes of renal alpha1-adrenoceptors in streptozotocin-induced diabetic and normal Sprague-Dawley rats. Autonomic & autacoid pharmacology. 2008 Jan; 28(1):1-10. doi: 10.1111/j.1474-8673.2007.00412.x. [PMID: 18257746]
  • S Hanafy, N J Dagenais, W F Dryden, F Jamali. Effects of angiotensin II blockade on inflammation-induced alterations of pharmacokinetics and pharmacodynamics of calcium channel blockers. British journal of pharmacology. 2008 Jan; 153(1):90-9. doi: 10.1038/sj.bjp.0707538. [PMID: 17965735]
  • Ying Liu, Feng-Guo Xul, Zun-Jian Zhang, Rui Song, Yuan Tian, Yun Chen. Quantitative determination of nitrendipine in human plasma using high-performance liquid chromatography-mass spectrometry. Arzneimittel-Forschung. 2008; 58(3):111-6. doi: 10.1055/s-0031-1296478. [PMID: 18488806]
  • Zheng-hai Long, Zai-chang Yang, Xiong-zhi Yang. [Study on skin toxicology and penetration enhancement of skin absorption of volatile oil extracted from tender branchers of Camellia oleifera]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2007 Sep; 32(17):1780-3. doi: ". [PMID: 17993001]
  • Kavi J Littlewood, Wolfgang Greiner, Dominique Baum, York Zoellner. Adjunctive treatment with moxonidine versus nitrendipine for hypertensive patients with advanced renal failure: a cost-effectiveness analysis. BMC nephrology. 2007 Jul; 8(?):9. doi: 10.1186/1471-2369-8-9. [PMID: 17645811]
  • Venishetty Vinay Kumar, Durairaj Chandrasekar, Sistla Ramakrishna, Veerabrahma Kishan, Yamsani Madhusudan Rao, Prakash Vamanrao Diwan. Development and evaluation of nitrendipine loaded solid lipid nanoparticles: influence of wax and glyceride lipids on plasma pharmacokinetics. International journal of pharmaceutics. 2007 Apr; 335(1-2):167-175. doi: 10.1016/j.ijpharm.2006.11.004. [PMID: 17161566]
  • Vinay Kumar Venishetty, Chandrasekar Durairaj, Ramakrishna Sistla, Madhusudhan Rao Yamsani, Prakash V Diwan. Development and validation of a reversed-phase HPLC method for determination of nitrendipine in rat plasma: application to pharmacokinetic studies. Biomedical chromatography : BMC. 2007 Apr; 21(4):363-8. doi: 10.1002/bmc.761. [PMID: 17236247]
  • Li-Lin Liu, Qi-Xiong Li, Lin Xia, Jing Li, Lang Shao. Differential effects of dihydropyridine calcium antagonists on doxorubicin-induced nephrotoxicity in rats. Toxicology. 2007 Feb; 231(1):81-90. doi: 10.1016/j.tox.2006.11.067. [PMID: 17234320]
  • Leszek Czupryniak, Maciej Pawłowski, Małgorzata Saryusz-Wolska, Jerzy Loba. Circadian blood pressure variation and antihypertensive medication adjustment in normoalbuminuric type 2 diabetes patients. Kidney & blood pressure research. 2007; 30(3):182-6. doi: 10.1159/000103231. [PMID: 17536225]
  • Toshihiko Ishimitsu, Takeaki Honda, Satoshi Ohta, Akira Akashiba, Toshiaki Takahashi, Tomoko Kameda, Masayoshi Yoshii, Junichi Minami, Masaki Takahashi, Hidehiko Ono, Hiroaki Matsuoka. Cardiorenal protective effects of year-long antihypertensive therapy with an angiotensin-converting enzyme inhibitor or a calcium channel blocker in spontaneously hypertensive rats. American journal of hypertension. 2006 Dec; 19(12):1233-40. doi: 10.1016/j.amjhyper.2006.05.019. [PMID: 17161768]
  • Kopparam Manjunath, Vobalaboina Venkateswarlu. Pharmacokinetics, tissue distribution and bioavailability of nitrendipine solid lipid nanoparticles after intravenous and intraduodenal administration. Journal of drug targeting. 2006 Nov; 14(9):632-45. doi: 10.1080/10611860600888850. [PMID: 17090399]
  • Kenji Moriyama, Naotetsu Kanamoto, Yuji Hataya, Takuo Nanbu, Kiminori Hosoda, Hiroshi Arai, Kazuwa Nakao. A case of type 2 diabetes mellitus developing hypothyroidism discovered as a result of a discrepancy between glycated hemoglobin and glycated albumin values. Diabetes research and clinical practice. 2006 Mar; 71(3):227-32. doi: 10.1016/j.diabres.2005.06.013. [PMID: 16112242]
  • Dorota Kowalczuk, Maria Bozena Wawrzycka, Agnieszka Haratym Maj. Determination of nifedipine in serum of women in preterm labor by high-performance liquid chromatography with diode array detection. Journal of AOAC International. 2006 Jan; 89(1):71-7. doi: 10.1093/jaoac/89.1.71. [PMID: 16512231]
  • Satsuki Koida, Mitsumasa Ohyanagi, Atsunori Ueda, Yoshitomo Mori, Tadaaki Iwasaka. Mechanism of increased alpha-adrenoceptor-mediated contraction in small resistance arteries of rats with heart failure. Clinical and experimental pharmacology & physiology. 2006 Jan; 33(1-2):47-52. doi: 10.1111/j.1440-1681.2006.04322.x. [PMID: 16445698]
  • A Belic, I Grabnar, I Belic, R Karba, A Mrhar. Predicting the anti-hypertensive effect of nitrendipine from plasma concentration profiles using artificial neural networks. Computers in biology and medicine. 2005 Dec; 35(10):892-904. doi: 10.1016/j.compbiomed.2004.07.006. [PMID: 16310013]
  • Yi Zhang, Anshul Gupta, Honggang Wang, Lin Zhou, R Robert Vethanayagam, Jashvant D Unadkat, Qingcheng Mao. BCRP transports dipyridamole and is inhibited by calcium channel blockers. Pharmaceutical research. 2005 Dec; 22(12):2023-34. doi: 10.1007/s11095-005-8384-4. [PMID: 16247709]
  • Mingshi Yang, Fude Cui, Bengang You, Minghua Yang, Anjin Tao, Dongmei Cun, Yoshiaki Kawashima. In vivo evaluation of two novel controlled-release nitrendipine formulations. Drug development and industrial pharmacy. 2005 Aug; 31(7):589-95. doi: 10.1080/03639040500215974. [PMID: 16207605]
  • A M Mitchell, M Tom, R H Mortimer. Thyroid hormone export from cells: contribution of P-glycoprotein. The Journal of endocrinology. 2005 Apr; 185(1):93-8. doi: 10.1677/joe.1.06096. [PMID: 15817830]
  • He-Hui Xie, Chao-Yu Miao, Yuan-Ying Jiang, Ding-Feng Su. Synergism of atenolol and nitrendipine on hemodynamic amelioration and organ protection in hypertensive rats. Journal of hypertension. 2005 Jan; 23(1):193-201. doi: 10.1097/00004872-200501000-00030. [PMID: 15643142]
  • K K Machavaram, J Gundu, M R Yamsani. Effect of various cytochrome P450 3A and P-glycoprotein modulators on the biliary clearance of bromosulphaphthalein in male wistar rats. Die Pharmazie. 2004 Dec; 59(12):957-60. doi: . [PMID: 15638086]
  • Alexandra Corrales, Fang Xu, Zayra V Garavito-Aguilar, Thomas J J Blanck, Esperanza Recio-Pinto. Isoflurane reduces the carbachol-evoked Ca2+ influx in neuronal cells. Anesthesiology. 2004 Oct; 101(4):895-901. doi: 10.1097/00000542-200410000-00014. [PMID: 15448522]
  • Ming-shi Yang, Ben-gang You, Ming-hua Yang, Dong-mei Cun, An-jin Tao, Fu-de Cui. [Evaluation of in vitro/in vivo correlation for three kinds of self-designed sustained-release nitrendipine formulations using deconvolution method]. Yao xue xue bao = Acta pharmaceutica Sinica. 2004 Sep; 39(9):738-41. doi: NULL. [PMID: 15606026]
  • A Armenia, A S Munavvar, N A Abdullah, A Helmi, E J Johns. The contribution of adrenoceptor subtype(s) in the renal vasculature of diabetic spontaneously hypertensive rats. British journal of pharmacology. 2004 Jun; 142(4):719-26. doi: 10.1038/sj.bjp.0705842. [PMID: 15172958]
  • P Das, C L Bell-Horner, R Q Huang, A Raut, E B Gonzales, Z L Chen, D F Covey, G H Dillon. Inhibition of type A GABA receptors by L-type calcium channel blockers. Neuroscience. 2004; 124(1):195-206. doi: 10.1016/j.neuroscience.2003.12.005. [PMID: 14960351]
  • Ichiro Niki, Tae Niwa, Wei Yu, Dorota Budzko, Takashi Miki, Takao Senda. Ca2+ influx does not trigger glucose-induced traffic of the insulin granules and alteration of their distribution. Experimental biology and medicine (Maywood, N.J.). 2003 Nov; 228(10):1218-26. doi: 10.1177/153537020322801019. [PMID: 14610264]
  • Oliver Vonend, Parvaneh Marsalek, Hagen Russ, Ralf Wulkow, Vitus Oberhauser, Lars C Rump. Moxonidine treatment of hypertensive patients with advanced renal failure. Journal of hypertension. 2003 Sep; 21(9):1709-17. doi: 10.1097/00004872-200309000-00021. [PMID: 12923404]
  • L F Morrone, A Ramunni, E Fassianos, A Saracino, P Coratelli, G Passavanti. Nitrendipine and amlodipine mimic the acute effects of enalapril on renal haemodynamics and reduce glomerular hyperfiltration in patients with chronic kidney disease. Journal of human hypertension. 2003 Jul; 17(7):487-93. doi: 10.1038/sj.jhh.1001579. [PMID: 12821956]
  • Birgitte Nielsen, Henning Grønbaek, Ruth Osterby, Allan Flyvbjerg. Effect of combination therapy with a calcium channel blocker and an angiotensin-converting enzyme inhibitor on renal hypertrophy and urinary albumin excretion in diabetic rats. Experimental diabesity research. 2003 Jul; 4(3):191-9. doi: 10.1155/edr.2003.191. [PMID: 15061647]
  • Soo Yeon Oh, Kwang Youl Kim, Yoon Gyoon Kim, Hyung-Gun Kim. High-performance liquid chromatographic analysis of nitrendipine in human plasma using ultraviolet detection and single-step solid-phase sample preparation. Journal of pharmaceutical and biomedical analysis. 2003 Jun; 32(2):387-92. doi: 10.1016/s0731-7085(03)00129-8. [PMID: 12763551]
  • Gérard M London, Sylvain J Marchais, Alain P Guerin, Fabien Metivier, Hassan Adda, Bruno Pannier. Inflammation, arteriosclerosis, and cardiovascular therapy in hemodialysis patients. Kidney international. Supplement. 2003 May; ?(84):S88-93. doi: 10.1046/j.1523-1755.63.s84.25.x. [PMID: 12694318]
  • Anindya Bhattacharya, Kathryn W Schenck, Marlene L Cohen. Amplification of sumatriptan-induced contraction in rabbit saphenous vein but not in basilar artery. American journal of physiology. Heart and circulatory physiology. 2003 Feb; 284(2):H719-26. doi: 10.1152/ajpheart.00345.2002. [PMID: 12424094]
  • He-Hui Xie, Chao-Yu Miao, Jian-Guo Liu, Ding-Feng Su. Importance of blood pressure variability in organ protection in spontaneously hypertensive rats treated with combination of nitrendipine and atenolol. Acta pharmacologica Sinica. 2002 Dec; 23(12):1199-204. doi: NULL. [PMID: 12466061]
  • Salomón Muchnik, Adriana Losavio, Silvana De Lorenzo. Effect of amyotrophic lateral sclerosis serum on calcium channels related to spontaneous acetylcholine release. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 2002 Jul; 113(7):1066-71. doi: 10.1016/s1388-2457(02)00108-6. [PMID: 12088701]
  • Wendy B Bollag, EunMi Jung, Roberto A Calle. Mechanism of angiotensin II-induced phospholipase D activation in bovine adrenal glomerulosa cells. Molecular and cellular endocrinology. 2002 Jun; 192(1-2):7-16. doi: 10.1016/s0303-7207(02)00134-x. [PMID: 12088862]
  • Kohsaku Kawakami, Takayoshi Yoshikawa, Takashi Hayashi, Yoshitaka Nishihara, Kazuyoshi Masuda. Microemulsion formulation for enhanced absorption of poorly soluble drugs. II. In vivo study. Journal of controlled release : official journal of the Controlled Release Society. 2002 May; 81(1-2):75-82. doi: 10.1016/s0168-3659(02)00050-0. [PMID: 11992680]
  • Zhi-Chao Li, Fu-Qin Zhang, Jing-Chun Song, Qi-Bing Mei, De-Hua Zhao. Therapeutic effects of DCDDP, a calcium channel blocker, on chronic pulmonary hypertension in rat. Journal of applied physiology (Bethesda, Md. : 1985). 2002 Mar; 92(3):997-1003. doi: 10.1152/japplphysiol.00237.2001. [PMID: 11842032]
  • X Chen, D Zhong, H Yang, Y Luan, H Xu. Quantitative determination of nitrendipine and its metabolite dehydronitrendipine in human plasma using liquid chromatography-tandem mass spectrometry. Biomedical chromatography : BMC. 2001 Dec; 15(8):518-24. doi: 10.1002/bmc.104. [PMID: 11748687]
  • H A Praetorius, K R Spring. Bending the MDCK cell primary cilium increases intracellular calcium. The Journal of membrane biology. 2001 Nov; 184(1):71-9. doi: 10.1007/s00232-001-0075-4. [PMID: 11687880]
  • D Zhong, X Chen, J Gu, X Li, J Guo. Applications of liquid chromatography-tandem mass spectrometry in drug and biomedical analyses. Clinica chimica acta; international journal of clinical chemistry. 2001 Nov; 313(1-2):147-50. doi: 10.1016/s0009-8981(01)00667-2. [PMID: 11694253]
  • J L Megnien, A Simon, E Mikaberidze, N Denarie, G Chironi, J Barra, R Armentano, J Levenson. Do arterial effects of antihypertensive drugs depend on subject's serum cholesterol?. Journal of cardiovascular pharmacology. 2001 Oct; 38(4):520-8. doi: 10.1097/00005344-200110000-00004. [PMID: 11588522]
  • D Kopf, H Schmitz, J Beyer, M Frank, A Bockisch, H Lehnert. A double-blind trial of perindopril and nitrendipine in incipient diabetic nephropathy. Diabetes, nutrition & metabolism. 2001 Oct; 14(5):245-52. doi: . [PMID: 11806464]
  • W Li, M C Farach-Carson. Parathyroid hormone-stimulated resorption in calvaria cultured in serum-free medium is enhanced by the calcium-mobilizing activity of 1,25-dihydroxyvitamin D(3). Bone. 2001 Sep; 29(3):231-5. doi: 10.1016/s8756-3282(01)00572-5. [PMID: 11557366]
  • W Xu, D Lipscombe. Neuronal Ca(V)1.3alpha(1) L-type channels activate at relatively hyperpolarized membrane potentials and are incompletely inhibited by dihydropyridines. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2001 Aug; 21(16):5944-51. doi: 10.1523/jneurosci.21-16-05944.2001. [PMID: 11487617]
  • A Charbonneau, M Leclerc, M G Brunette. Effect of angiotensin II on calcium reabsorption by the luminal membranes of the nephron. American journal of physiology. Endocrinology and metabolism. 2001 Jun; 280(6):E928-36. doi: 10.1152/ajpendo.2001.280.6.e928. [PMID: 11350774]
  • A M Buchan, P E Squires, M Ring, R M Meloche. Mechanism of action of the calcium-sensing receptor in human antral gastrin cells. Gastroenterology. 2001 Apr; 120(5):1128-39. doi: 10.1053/gast.2001.23246. [PMID: 11266377]
  • J G Wang, J A Staessen, R H Fagard, W H Birkenhäger, L Gong, L Liu. Prognostic significance of serum creatinine and uric acid in older Chinese patients with isolated systolic hypertension. Hypertension (Dallas, Tex. : 1979). 2001 Apr; 37(4):1069-74. doi: 10.1161/01.hyp.37.4.1069. [PMID: 11304505]
  • C L Lin, Z X Zhang, Y J Xu. [Effect of combination of ligustrazine and nitrendipine on hemodynamics in patients with chronic obstructive pulmonary disease]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2001 Mar; 21(3):183-5. doi: ". [PMID: 12577333]
  • S M Voyaki, J A Staessen, L Thijs, J G Wang, A D Efstratopoulos, W H Birkenhäger, P W de Leeuw, G Leonetti, C Nachev, J L Rodicio, J Tuomilehto, R Fagard. Follow-up of renal function in treated and untreated older patients with isolated systolic hypertension. Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. Journal of hypertension. 2001 Mar; 19(3):511-9. doi: 10.1097/00004872-200103000-00020. [PMID: 11288822]
  • Y Matsumura, K Hayashi. Vatanidipine hydrochloride: a new long-lasting antihypertensive agent. Expert opinion on investigational drugs. 2001 Jan; 10(1):139-55. doi: 10.1517/13543784.10.1.139. [PMID: 11116287]
  • C L Lin, Z X Zhang, Y J Xu. [Therapeutic mechanism of combination therapy of ligustrazine and nitrendipine in treating patients with chronic obstructive pulmonary disease]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2001 Jan; 21(1):28-30. doi: NULL. [PMID: 12577373]
  • Y Ogawa, T Haneda, T Hirayama, H Ide, A Obara, J Maruyama, H Morimoto, H Tanaka, J Kato, T Hayakawa, N Hasebe, K Kikuchi. Effects of lisinopril and nitrendipine on urinary albumin excretion and renal function in patients with mild to moderate essential hypertension. Hypertension research : official journal of the Japanese Society of Hypertension. 2000 Nov; 23(6):607-12. doi: 10.1291/hypres.23.607. [PMID: 11131273]
  • H Shi, Y D Halvorsen, P N Ellis, W O Wilkison, M B Zemel. Role of intracellular calcium in human adipocyte differentiation. Physiological genomics. 2000 Aug; 3(2):75-82. doi: 10.1152/physiolgenomics.2000.3.2.75. [PMID: 11015602]
  • B Nielsen, H Grønbaek, R Osterby, A Flyvbjerg. Effect of nitrendipine and nisoldipine on renal structure and function in long-term experimental diabetes in rats. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2000 Aug; 36(2):368-77. doi: 10.1053/ajkd.2000.8988. [PMID: 10922316]
  • S Bastianetto, W H Zheng, R Quirion. The Ginkgo biloba extract (EGb 761) protects and rescues hippocampal cells against nitric oxide-induced toxicity: involvement of its flavonoid constituents and protein kinase C. Journal of neurochemistry. 2000 Jun; 74(6):2268-77. doi: 10.1046/j.1471-4159.2000.0742268.x. [PMID: 10820186]
  • K Watanabe, T Tsuruoka, K Kawai, T Ishizu, J Suzuki, S Sueda, S Ikeda. [Usefulness of nitrendipine and its effects on quality of life and brain blood flow in elderly hypertensive patients]. Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics. 2000 Apr; 37(4):309-16. doi: 10.3143/geriatrics.37.309. [PMID: 10917029]
  • O Terland, T Flatmark. Energy-dependent accumulation of calcium antagonists in catecholamine storage vesicles. Biochemical pharmacology. 2000 Jan; 59(2):123-9. doi: 10.1016/s0006-2952(99)00307-x. [PMID: 10810446]
  • H L Wang, S A Kilfeather, G R Martin, C P Page. Effects of tetrandrine on growth factor-induced DNA synthesis and proliferative response of rat pulmonary artery smooth muscle cells. Pulmonary pharmacology & therapeutics. 2000; 13(2):53-60. doi: 10.1006/pupt.2000.0230. [PMID: 10799282]
  • N Mikoda, H Nakagawa, K Kawahara. [Effects of nitrendipine on the development of hypertension and renal failure in Dahl salt-sensitive rats]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1999 Dec; 114(6):373-82. doi: 10.1254/fpj.114.373. [PMID: 10672598]
  • K H Rahn, M Barenbrock, E Fritschka, A Heinecke, J Lippert, K Schroeder, I Hauser, K Wagner, H H Neumayer. Effect of nitrendipine on renal function in renal-transplant patients treated with cyclosporin: a randomised trial. Lancet (London, England). 1999 Oct; 354(9188):1415-20. doi: 10.1016/s0140-6736(99)08421-4. [PMID: 10543667]
  • T Heise, L Heinemann, K Kristahn, M Berger, P T Sawicki. Insulin sensitivity in patients with essential hypertension: no influence of the ACE inhibitor enalapril. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 1999 Jul; 31(7):418-23. doi: 10.1055/s-2007-978766. [PMID: 10450833]
  • Iu I Gubskiĭ, A G Goriushko, N V Litvinova, R G Pirmak, N M Kruskaia, E V Shnurko, L G Sachenko. [Antioxidant properties and membranotropic effect of certain derivatives of 1,4-dihydropyridine]. Ukrains'kyi biokhimichnyi zhurnal (1999 ). 1999 Jul; 71(4):35-9. doi: NULL. [PMID: 10791054]
  • L Liu, J G Wang, H Celis, J A Staessen. Implications of the Systolic Hypertension in China trial. Clinical and experimental hypertension (New York, N.Y. : 1993). 1999 Jul; 21(5-6):499-505. doi: 10.3109/10641969909060983. [PMID: 10423076]
  • T Ishimitsu, J Minami, Y Kawano, A Numabe, S Takishita, H Matsuoka. Amlodipine, a long-acting calcium channel blocker, attenuates morning blood pressure rise in hypertensive patients. Clinical and experimental pharmacology & physiology. 1999 Jul; 26(7):500-4. doi: 10.1046/j.1440-1681.1999.03072.x. [PMID: 10405773]
  • B Nielsen, H Grønbaek, R Osterby, A Flyvbjerg. Effect of the calcium channel blocker nitrendipine in normotensive and spontaneously hypertensive, diabetic rats on kidney morphology and urinary albumin excretion. Journal of hypertension. 1999 Jul; 17(7):973-81. doi: 10.1097/00004872-199917070-00014. [PMID: 10419071]
  • K Sakata, M Shirotani, H Yoshida, T Urano, Y Takada, A Takada. Differential effects of enalapril and nitrendipine on the fibrinolytic system in essential hypertension. American heart journal. 1999 Jun; 137(6):1094-9. doi: 10.1016/s0002-8703(99)70368-6. [PMID: 10347337]
  • B Nielsen, H Gronbaek, R Osterby, H Orskov, A Flyvbjerg. The calcium channel blocker nitrendipine attenuates renal and glomerular hypertrophy in diabetic rats. Experimental nephrology. 1999 May; 7(3):242-50. doi: 10.1159/000020608. [PMID: 10352365]
  • J Manitius, E J Johns, A L Chamienia. The effect of nitrendipine on renal haemodynamics and tubular reabsorption and its neural control in anaesthetised rats with chronic renal failure. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 1999 Mar; 50(1):89-98. doi: NULL. [PMID: 10210157]
  • P Ruggenenti, L Mosconi, F Sangalli, F Casiraghi, V Gambara, G Remuzzi, A Remuzzi. Glomerular size-selective dysfunction in NIDDM is not ameliorated by ACE inhibition or by calcium channel blockade. Kidney international. 1999 Mar; 55(3):984-94. doi: 10.1046/j.1523-1755.1999.055003984.x. [PMID: 10027935]
  • V Schwenger, M Zeier, E Ritz. Antihypertensive therapy in renal patients - benefits and difficulties. Nephron. 1999; 83(3):202-13. doi: 10.1159/000045512. [PMID: 10529626]
  • R Fogari, A Zoppi, L Corradi, A Mugellini, P Lazzari, P Preti, P Lusardi. Long-term effects of ramipril and nitrendipine on albuminuria in hypertensive patients with type II diabetes and impaired renal function. Journal of human hypertension. 1999 Jan; 13(1):47-53. doi: 10.1038/sj.jhh.1000732. [PMID: 9928752]
  • L Liu, J G Wang, L Gong, G Liu, J A Staessen. Comparison of active treatment and placebo in older Chinese patients with isolated systolic hypertension. Systolic Hypertension in China (Syst-China) Collaborative Group. Journal of hypertension. 1998 Dec; 16(12 Pt 1):1823-9. doi: 10.1097/00004872-199816120-00016. [PMID: 9869017]
  • T D Plant, C Schirra, E Katz, O D Uchitel, A Konnerth. Single-cell RT-PCR and functional characterization of Ca2+ channels in motoneurons of the rat facial nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1998 Dec; 18(23):9573-84. doi: 10.1523/jneurosci.18-23-09573.1998. [PMID: 9822718]
  • S Kanda, S Adachi-Akahane, T Nagao. Functional interaction between benzothiazepine- and dihydropyridine binding sites of cardiac L-type Ca2+ channels. European journal of pharmacology. 1998 Oct; 358(3):277-87. doi: 10.1016/s0014-2999(98)00606-2. [PMID: 9822895]