FLUOCINONIDE (BioDeep_00000398799)
Main id: BioDeep_00000002318
natural product
代谢物信息卡片
化学式: C26H32F2O7 (494.21159859999995)
中文名称: 氟环素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)OCC(=O)C12C(CC3C1(CC(C4(C3CC(C5=CC(=O)C=CC54C)F)F)O)C)OC(O2)(C)C
InChI: InChI=1S/C26H32F2O7/c1-13(29)33-12-20(32)26-21(34-22(2,3)35-26)10-15-16-9-18(27)17-8-14(30)6-7-23(17,4)25(16,28)19(31)11-24(15,26)5/h6-8,15-16,18-19,21,31H,9-12H2,1-5H3/t15-,16-,18-,19-,21+,23-,24-,25-,26+/m0/s1
描述信息
C - Cardiovascular system > C05 - Vasoprotectives > C05A - Agents for treatment of hemorrhoids and anal fissures for topical use > C05AA - Corticosteroids
D - Dermatologicals > D07 - Corticosteroids, dermatological preparations > D07A - Corticosteroids, plain > D07AC - Corticosteroids, potent (group iii)
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D005938 - Glucocorticoids
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
D000893 - Anti-Inflammatory Agents
D018926 - Anti-Allergic Agents
同义名列表
1 个代谢物同义名
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:5109
- KEGG: C07007
- KEGGdrug: D00325
- PubChem: 9642
- DrugBank: DB01047
- ChEMBL: CHEMBL1501
- MeSH: Fluocinonide
- CAS: 356-12-7
- MoNA: CCMSLIB00000077112
- PubChem: 9220
- RefMet: Fluocinonide
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Zhi-Qiang Chen, Ying Liu, Ji-Hui Zhao, Lan Wang, Nian-Ping Feng. Improved oral bioavailability of poorly water-soluble indirubin by a supersaturatable self-microemulsifying drug delivery system.
International journal of nanomedicine.
2012; 7(?):1115-25. doi:
10.2147/ijn.s28761. [PMID: 22403491] - Mihoko Ohshima, Mio Miyake, Masanori Takeda, Michihiro Kamijima, Tatsuo Sakamoto. Staphylococcal enterotoxin B causes proliferation of sensory C-fibers and subsequent enhancement of neurogenic inflammation in rat skin.
The Journal of infectious diseases.
2011 Mar; 203(6):862-9. doi:
10.1093/infdis/jiq128. [PMID: 21252260] - Andrea Suárez, Scott Freeman, Lauren Puls, Robert Dellavalle. Unusual presentation of cactus spines in the flank of an elderly man: a case report.
Journal of medical case reports.
2010 May; 4(?):152. doi:
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Proceedings of the National Academy of Sciences of the United States of America.
2010 May; 107(20):9323-8. doi:
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Skinmed.
2006 Jul; 5(4):199-201. doi:
10.1111/j.1540-9740.2006.04841.x. [PMID: 16855416] - Yubo Li. Determination of imperatorin in rat plasma by reversed-phase high-performance liquid chromatography after oral administration of Radix Angelicae dahuricae extract.
Journal of pharmaceutical and biomedical analysis.
2006 Mar; 40(5):1253-6. doi:
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Journal of chromatographic science.
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Thyroid : official journal of the American Thyroid Association.
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The British journal of dermatology.
1999 Apr; 140 Suppl 54(?):24-8. doi:
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Oral diseases.
1999 Jan; 5(1):44-9. doi:
10.1111/j.1601-0825.1999.tb00063.x. [PMID: 10218041] - H S Zackheim, M Kashani-Sabet, S Amin. Topical corticosteroids for mycosis fungoides. Experience in 79 patients.
Archives of dermatology.
1998 Aug; 134(8):949-54. doi:
10.1001/archderm.134.8.949. [PMID: 9722724] - D G Spoerke, S E Spoerke. Granuloma formation induced by spines of the cactus, Opuntia acanthocarpa.
Veterinary and human toxicology.
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Oral surgery, oral medicine, and oral pathology.
1990 Jun; 69(6):688-93. doi:
10.1016/0030-4220(90)90349-w. [PMID: 2356081] - R D Zenoble, R J Kemppainen. Adrenocortical suppression by topically applied corticosteroids in healthy dogs.
Journal of the American Veterinary Medical Association.
1987 Sep; 191(6):685-8. doi:
. [PMID: 2824410] - B Jegasothy, C Jacobson, N Levine, L Millikan, E Olsen, S Pinnell, G Cole, G Weinstein, M Porter. Clobetasol propionate versus fluocinonide creams in psoriasis and eczema.
International journal of dermatology.
1985 Sep; 24(7):461-5. doi:
10.1111/j.1365-4362.1985.tb05821.x. [PMID: 3902682] - K Yamada, T Satoh. In vivo effects of glucocorticoids on serum corticosterone levels in rats.
Research communications in chemical pathology and pharmacology.
1985 Mar; 47(3):441-4. doi:
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Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
1984 Dec; 84(6):553-61. doi:
10.1254/fpj.84.553. [PMID: 6519585] - E Novak, S F Francom, C A Schlagel. Adrenal suppression with high-potency corticosteroid ointment formulations in normal subjects.
Clinical therapeutics.
1983; 6(1):59-71. doi:
. [PMID: 6370438] - D D Munro. The effect of percutaneously absorbed steroids on hypothalamic--pituitary--adrenal function after intensive use in in-patients.
The British journal of dermatology.
1976 Mar; 94 suppl 12(?):67-76. doi:
10.1111/j.1365-2133.1976.tb02272.x. [PMID: 1268079]