lactulose (BioDeep_00000398727)
Main id: BioDeep_00000003234
代谢物信息卡片
4-O-hexopyranosylhex-2-ulofuranose
化学式: C12H22O11 (342.11620619999997)
中文名称: 乳果糖
谱图信息:
最多检出来源 Homo sapiens(urine) 17.24%
分子结构信息
SMILES: C(C1C(C(C(C(O1)OC2C(OC(C2O)(CO)O)CO)O)O)O)O
InChI: InChI=1S/C12H22O11/c13-1-4-6(16)7(17)8(18)11(21-4)22-9-5(2-14)23-12(20,3-15)10(9)19/h4-11,13-20H,1-3H2
描述信息
A - Alimentary tract and metabolism > A06 - Drugs for constipation > A06A - Drugs for constipation > A06AD - Osmotically acting laxatives
C78276 - Agent Affecting Digestive System or Metabolism > C29697 - Laxative
D005765 - Gastrointestinal Agents
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.054
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.051
同义名列表
3 个代谢物同义名
数据库引用编号
36 个数据库交叉引用编号
- ChEBI: CHEBI:6359
- KEGG: C07064
- KEGGdrug: D00352
- PubChem: 11333
- PubChem: 11024312
- PubChem: 3872
- DrugBank: DB00581
- ChEMBL: CHEMBL296306
- ChEMBL: CHEMBL58143
- MeSH: Lactulose
- CAS: 58166-24-8
- CAS: 58166-25-9
- CAS: 4618-18-2
- MoNA: MoNA038814
- MoNA: MoNA038294
- MoNA: MoNA037544
- MoNA: MoNA036770
- MoNA: MoNA036769
- MoNA: MoNA036765
- MoNA: MoNA034835
- MoNA: MoNA034834
- MoNA: MoNA034833
- MoNA: MoNA032679
- MoNA: MoNA032678
- MoNA: MoNA032676
- MoNA: HMDB0000740_ms_ms_1218116
- MoNA: HMDB0000740_ms_ms_1218117
- MoNA: HMDB0000740_ms_ms_1218115
- MoNA: FiehnHILIC001292
- MoNA: BML81563
- MoNA: BML81561
- MoNA: BML81560
- PubChem: 9276
- PDB-CCD: W9T
- NIKKAJI: J86.091C
- RefMet: Lactulose
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Michele Linsalata, Francesco Russo, Giuseppe Riezzo, Benedetta D'Attoma, Laura Prospero, Antonella Orlando, Antonia Ignazzi, Martina Di Chito, Annamaria Sila, Sara De Nucci, Roberta Rinaldi, Gianluigi Giannelli, Giovanni De Pergola. The Effects of a Very-Low-Calorie Ketogenic Diet on the Intestinal Barrier Integrity and Function in Patients with Obesity: A Pilot Study.
Nutrients.
2023 May; 15(11):. doi:
10.3390/nu15112561. [PMID: 37299524] - Hala Abdallah, Mohamad Khalil, Ilaria Farella, Jerlin Stephy JohnBritto, Elisa Lanza, Sergio Santoro, Gabriella Garruti, Piero Portincasa, Agostino Di Ciaula, Leonilde Bonfrate. Ramadan intermittent fasting reduces visceral fat and improves gastrointestinal motility.
European journal of clinical investigation.
2023 May; ?(?):. doi:
10.1111/eci.14029. [PMID: 37203871] - Modou Jobe, Schadrac C Agbla, Marijana Todorcevic, Bakary Darboe, Ebrima Danso, Jean-Paul Pais de Barros, Laurent Lagrost, Fredrik Karpe, Andrew M Prentice. Possible mediators of metabolic endotoxemia in women with obesity and women with obesity-diabetes in The Gambia.
International journal of obesity (2005).
2022 10; 46(10):1892-1900. doi:
10.1038/s41366-022-01193-1. [PMID: 35933445] - Cíntia Tomaz Sant'Ana, Ariane Dias de Amorim, Ana Paula Gava, Carla Mora Aguilar, Nayana Garcia Silva, Líllian Duarte Machado, Mirelle Lomar Viana, Daniela da Silva Oliveira, Pollyanna Ibrahim Silva, Neuza Maria Brunoro Costa, André Gustavo Vasconcelos Costa. Brown and golden flaxseed reduce intestinal permeability and endotoxemia, and improve the lipid profile in perimenopausal overweight women.
International journal of food sciences and nutrition.
2022 Sep; 73(6):829-840. doi:
10.1080/09637486.2022.2052820. [PMID: 35311432] - Ben J Lee, Tessa R Flood, Ania M Hiles, Ella F Walker, Lucy E V Wheeler, Kimberly M Ashdown, Mark E T Willems, Rianne Costello, Luke D Greisler, Phebe A Romano, Garrett W Hill, Matthew R Kuennen. Anthocyanin-Rich Blackcurrant Extract Preserves Gastrointestinal Barrier Permeability and Reduces Enterocyte Damage but Has No Effect on Microbial Translocation and Inflammation After Exertional Heat Stress.
International journal of sport nutrition and exercise metabolism.
2022 Jul; 32(4):265-274. doi:
10.1123/ijsnem.2021-0330. [PMID: 35287112] - Arwa Ahmed, Fateen Ata, Mohammed Gaber, Mahir Petkar, Ahmed Mahfouz, Peter Schirmacher, Sara Musa, Ahmed Hashim. Refractory Hyperammonemic encephalopathy in Fibrolamellar hepatocellular carcinoma, a case report and literature review.
Current problems in cancer.
2022 06; 46(3):100847. doi:
10.1016/j.currproblcancer.2022.100847. [PMID: 35276469] - Ivana R Sequeira, Marlena C Kruger, Roger D Hurst, Roger G Lentle. A Simple, Robust, and Convenient HPLC Assay for Urinary Lactulose and Mannitol in the Dual Sugar Absorption Test.
Molecules (Basel, Switzerland).
2022 Apr; 27(9):. doi:
10.3390/molecules27092677. [PMID: 35566024] - Mengting Li, Zhijie Zhang, Qiao Chen, Xiaoling Zhou, Diankui Shui, Jiean Huang. Comparative Effectiveness and Safety of Polyethylene Glycol Electrolyte Solution Versus Lactulose for Treatment of Hepatic Encephalopathy: A Systematic Review and Meta-analysis.
Journal of clinical gastroenterology.
2022 01; 56(1):41-48. doi:
10.1097/mcg.0000000000001621. [PMID: 34739404] - T C Chan, V M W Yu, J K H Luk, L W Chu, J K Y Yuen, F H W Chan. Effectiveness of Partially Hydrolyzed Guar Gum in Reducing Constipation in Long Term Care Facility Residents: A Randomized Single-Blinded Placebo-Controlled Trial.
The journal of nutrition, health & aging.
2022 ; 26(3):247-251. doi:
10.1007/s12603-022-1747-2. [PMID: 35297467] - Charlotte Bayer Christiansen, Simon Veedfald, Bolette Hartmann, Astrid Marie Gauguin, Søren Møller, Thomas Moritz, Sten Madsbad, Jens Juul Holst. Colonic Lactulose Fermentation Has No Impact on Glucagon-like Peptide-1 and Peptide-YY Secretion in Healthy Young Men.
The Journal of clinical endocrinology and metabolism.
2022 01; 107(1):77-87. doi:
10.1210/clinem/dgab666. [PMID: 34508600] - Junxiong Cheng, Yafang Chen, Wenfu Cao, Guoqing Zuo. Is rifaximin better than nonabsorbable disaccharides in hepatic encephalopathy?: A meta-analysis.
Medicine.
2021 Dec; 100(51):e28232. doi:
10.1097/md.0000000000028232. [PMID: 34941089] - Haitao Shi, Lijuan Mao, Lianli Wang, Xiaojing Quan, Xiaoyu Xu, Yan Cheng, Shanshan Zhu, Fei Dai. Small intestinal bacterial overgrowth and orocecal transit time in patients of nonalcoholic fatty liver disease.
European journal of gastroenterology & hepatology.
2021 12; 33(1S Suppl 1):e535-e539. doi:
10.1097/meg.0000000000002157. [PMID: 33867442] - Ivana Roosevelt Sequeira. Higher doses of ascorbic acid may have the potential to promote nutrient delivery via intestinal paracellular absorption.
World journal of gastroenterology.
2021 Oct; 27(40):6750-6756. doi:
10.3748/wjg.v27.i40.6750. [PMID: 34790005] - Shumao Cui, Jiayu Gu, Xuemei Liu, Dongyao Li, Bingyong Mao, Hao Zhang, Jianxin Zhao, Wei Chen. Lactulose significantly increased the relative abundance of Bifidobacterium and Blautia in mice feces as revealed by 16S rRNA amplicon sequencing.
Journal of the science of food and agriculture.
2021 Oct; 101(13):5721-5729. doi:
10.1002/jsfa.11181. [PMID: 33650140] - Haiyan Gao, Yueqi Qin, Jie Zeng, Qing Yang, Tian Jia. Dietary intervention with sialylated lactulose affects the immunomodulatory activities of mice.
Journal of dairy science.
2021 Sep; 104(9):9494-9504. doi:
10.3168/jds.2021-20327. [PMID: 34176623] - Zehra Jamil, Najeeha Talat Iqbal, Romana Idress, Zubair Ahmed, Kamran Sadiq, Indika Mallawaarachchi, Junaid Iqbal, Sana Syed, Aneeta Hotwani, Furqan Kabir, Kumail Ahmed, Sheraz Ahmed, Fayaz Umrani, Jennie Z Ma, Fatima Aziz, Adil Kalam, Sean R Moore, Syed Asad Ali. Gut integrity and duodenal enteropathogen burden in undernourished children with environmental enteric dysfunction.
PLoS neglected tropical diseases.
2021 07; 15(7):e0009584. doi:
10.1371/journal.pntd.0009584. [PMID: 34264936] - Jasmohan S Bajaj, Masoumeh Sikaroodi, Amirhossein Shamsaddini, Zachariah Henseler, Tasha Santiago-Rodriguez, Chathur Acharya, Andrew Fagan, Phillip B Hylemon, Michael Fuchs, Edith Gavis, Tonya Ward, Dan Knights, Patrick M Gillevet. Interaction of bacterial metagenome and virome in patients with cirrhosis and hepatic encephalopathy.
Gut.
2021 06; 70(6):1162-1173. doi:
10.1136/gutjnl-2020-322470. [PMID: 32998876] - Keisuke Yoshida, Rika Hirano, Yohei Sakai, Moonhak Choi, Mikiyasu Sakanaka, Shin Kurihara, Hisakazu Iino, Jin-Zhong Xiao, Takane Katayama, Toshitaka Odamaki. Bifidobacterium response to lactulose ingestion in the gut relies on a solute-binding protein-dependent ABC transporter.
Communications biology.
2021 05; 4(1):541. doi:
10.1038/s42003-021-02072-7. [PMID: 33972677] - Zhitong Deng, Zhuotao Fu, Wen Yan, Kechao Nie, Lingli Ding, Duanhua Ma, Haodong Huang, Tao Li, Jianxing Xie, Linchun Fu. The different effects of Chinese Herb Solid Drink and lactulose on gut microbiota in rats with slow transit constipation induced by compound diphenoxylate.
Food research international (Ottawa, Ont.).
2021 05; 143(?):110273. doi:
10.1016/j.foodres.2021.110273. [PMID: 33992373] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Sindhu Kashyap, Nirupama Shivakumar, Veerasamy Sejian, Nicolaas E P Deutz, Thomas Preston, Sheshshayee Sreeman, Sarita Devi, Anura V Kurpad. Goat milk protein digestibility in relation to intestinal function.
The American journal of clinical nutrition.
2021 04; 113(4):845-853. doi:
10.1093/ajcn/nqaa400. [PMID: 33677496] - Xiaoyu Zhang, Junping Zheng, Nan Jiang, Guangjun Sun, Xinkun Bao, Mingwang Kong, Xue Cheng, Aizhen Lin, Hongtao Liu. Modulation of gut microbiota and intestinal metabolites by lactulose improves loperamide-induced constipation in mice.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2021 Mar; 158(?):105676. doi:
10.1016/j.ejps.2020.105676. [PMID: 33310029] - Elise Mank, Dewi van Harskamp, Letty van Toledo, Johannes B van Goudoever, Henk Schierbeek. Simultaneous assessment of intestinal permeability and lactase activity in human-milk-fed preterm infants by sugar absorption test: Clinical implementation and analytical method.
Clinical nutrition (Edinburgh, Scotland).
2021 03; 40(3):1413-1419. doi:
10.1016/j.clnu.2020.08.034. [PMID: 32948350] - Y Sakai, H Hamano, H Ochi, F Abe, K Masuda, H Iino. Lactulose ingestion causes an increase in the abundance of gut-resident bifidobacteria in Japanese women: a randomised, double-blind, placebo-controlled crossover trial.
Beneficial microbes.
2021 Feb; 12(1):43-53. doi:
10.3920/bm2020.0100. [PMID: 33393445] - Chang Hu, Vikram Anjur, Krishnakant Saboo, K Rajender Reddy, Jacqueline O'Leary, Puneeta Tandon, Florence Wong, Guadalupe Garcia-Tsao, Patrick S Kamath, Jennifer C Lai, Scott W Biggins, Michael B Fallon, Paul Thuluvath, Ram M Subramanian, Benedict Maliakkal, Hugo Vargas, Leroy R Thacker, Ravishankar K Iyer, Jasmohan S Bajaj. Low Predictability of Readmissions and Death Using Machine Learning in Cirrhosis.
The American journal of gastroenterology.
2021 02; 116(2):336-346. doi:
10.14309/ajg.0000000000000971. [PMID: 33038139] - Ibukun Afolami, Folake Olukemi Samuel, Martin Mwangi, Michael Oderinde, Marlies Diepeveen-de Bruin, Alida Melse-Boonstra. Assessment of small-intestine permeability in healthy Nigerian children is altered by urinary volume and voiding status.
PloS one.
2021; 16(9):e0253436. doi:
10.1371/journal.pone.0253436. [PMID: 34543276] - Maria Fernanda Roca Rubio, Ulrika Eriksson, Robert J Brummer, Julia König. Short intense psychological stress induced by skydiving does not impair intestinal barrier function.
PloS one.
2021; 16(7):e0254280. doi:
10.1371/journal.pone.0254280. [PMID: 34237102] - Quan Yuan, Ling Xin, Song Han, Yue Su, Ruixia Wu, Xiaoxuan Liu, Jimusi Wuri, Ran Li, Tao Yan. Lactulose Improves Neurological Outcomes by Repressing Harmful Bacteria and Regulating Inflammatory Reactions in Mice After Stroke.
Frontiers in cellular and infection microbiology.
2021; 11(?):644448. doi:
10.3389/fcimb.2021.644448. [PMID: 34327147] - Williams Turpin, Sun-Ho Lee, Juan Antonio Raygoza Garay, Karen L Madsen, Jonathan B Meddings, Larbi Bedrani, Namita Power, Osvaldo Espin-Garcia, Wei Xu, Michelle I Smith, Anne M Griffiths, Paul Moayyedi, Dan Turner, Ernest G Seidman, A Hillary Steinhart, John K Marshall, Kevan Jacobson, David Mack, Hien Huynh, Charles N Bernstein, Andrew D Paterson, Kenneth Croitoru. Increased Intestinal Permeability Is Associated With Later Development of Crohn's Disease.
Gastroenterology.
2020 12; 159(6):2092-2100.e5. doi:
10.1053/j.gastro.2020.08.005. [PMID: 32791132] - D Viganó, F Zara, S Pinto, E Loddo, L Casula, M B Soru, G D'Ancona, M N D'Alterio, C Giuliani, S Angioni, P Usai. How is small bowel permeability in endometriosis patients? a case control pilot study.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2020 Nov; 36(11):1010-1014. doi:
10.1080/09513590.2020.1766440. [PMID: 32401078] - Alessandro Di Federico, Giacomo Nuvola, Monia Sisi, Barbara Lenzi, Elisabetta Nobili, Davide Campana. Hyperammonemic encephalopathy during XELOX regimen. Is it capecitabine or oxaliplatin responsible?.
Anti-cancer drugs.
2020 11; 31(10):1103-1105. doi:
10.1097/cad.0000000000000987. [PMID: 32826413] - Barbara Geerinckx, Rachel Hellemans, Amaryllis H Van Craenenbroeck, Sven Francque, Liesbeth De Waele, Jeroen Kerstens, Pieter-Jan Van Gaal, Bart Bracke, Peter Michielsen, Thomas Vanwolleghem. A rare case of hemodialysis-related portosystemic encephalopathy and review of the literature.
Acta clinica Belgica.
2020 Aug; 75(4):296-300. doi:
10.1080/17843286.2019.1595836. [PMID: 30919753] - Oana A Tatucu-Babet, Adrienne Forsyth, Emma Owen, Diana Navarro-Perez, Jessica Radcliffe, Devin Benheim, Himasha Mendis, Markandeya Jois, Catherine Itsiopoulos, Audrey C Tierney. Serum zonulin measured by enzyme-linked immunosorbent assay may not be a reliable marker of small intestinal permeability in healthy adults.
Nutrition research (New York, N.Y.).
2020 06; 78(?):82-92. doi:
10.1016/j.nutres.2020.05.003. [PMID: 32563954] - Henry B Ogden, Joanne L Fallowfield, Robert B Child, Glen Davison, Simon C Fleming, Robert M Edinburgh, Simon K Delves, Alison Millyard, Caroline S Westwood, Joseph D Layden. Reliability of gastrointestinal barrier integrity and microbial translocation biomarkers at rest and following exertional heat stress.
Physiological reports.
2020 03; 8(5):e14374. doi:
10.14814/phy2.14374. [PMID: 32170836] - Mark McOmber, Danny Rafati, Kevin Cain, Sridevi Devaraj, Erica M Weidler, Margaret Heitkemper, Robert J Shulman. Increased Gut Permeability in First-degree Relatives of Children with Irritable Bowel Syndrome or Functional Abdominal Pain.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.
2020 02; 18(2):375-384.e1. doi:
10.1016/j.cgh.2019.05.011. [PMID: 31100459] - Cláudia Amorim, Sara C Silvério, Beatriz B Cardoso, Joana I Alves, Maria Alcina Pereira, Lígia R Rodrigues. In vitro assessment of prebiotic properties of xylooligosaccharides produced by Bacillus subtilis 3610.
Carbohydrate polymers.
2020 Feb; 229(?):115460. doi:
10.1016/j.carbpol.2019.115460. [PMID: 31826467] - Hu Cai, Qinfei Zhou, Guanai Bao, Xiangming Kong, Li-Yan Gong. Transcutaneous electrical nerve stimulation of acupuncture points enhances therapeutic effects of oral lactulose solution on opioid-induced constipation.
The Journal of international medical research.
2019 Dec; 47(12):6337-6348. doi:
10.1177/0300060519874539. [PMID: 31774002] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Mengdi Song, Jie Zeng, Tian Jia, Haiyan Gao, Ruiyao Zhang, Jikai Jiang, Guanglei Li, Tongchao Su. Effects of sialylated lactulose on the mouse intestinal microbiome using Illumina high-throughput sequencing.
Applied microbiology and biotechnology.
2019 Nov; 103(21-22):9067-9076. doi:
10.1007/s00253-019-10169-7. [PMID: 31659420] - Maciej Hałasa, Dominika Maciejewska, Karina Ryterska, Magdalena Baśkiewicz-Hałasa, Krzysztof Safranow, Ewa Stachowska. Assessing the Association of Elevated Zonulin Concentration in Stool with Increased Intestinal Permeability in Active Professional Athletes.
Medicina (Kaunas, Lithuania).
2019 Oct; 55(10):. doi:
10.3390/medicina55100710. [PMID: 31640273] - Ji Yao Wang, Jasmohan S Bajaj, Jiang Bin Wang, Jia Shang, Xin Min Zhou, Xiao Lin Guo, Xuan Zhu, Li Na Meng, Hai Xing Jiang, Yu Qiang Mi, Jian Ming Xu, Jin Hui Yang, Bai Song Wang, Ning Ping Zhang. Lactulose improves cognition, quality of life, and gut microbiota in minimal hepatic encephalopathy: A multicenter, randomized controlled trial.
Journal of digestive diseases.
2019 Oct; 20(10):547-556. doi:
10.1111/1751-2980.12816. [PMID: 31448533] - Jakub Ruszkowski, Jacek M Witkowski. Lactulose: Patient- and dose-dependent prebiotic properties in humans.
Anaerobe.
2019 Oct; 59(?):100-106. doi:
10.1016/j.anaerobe.2019.06.002. [PMID: 31176002] - Marisa da Fonseca Ferreira, Silke Salavati Schmitz, Jeffrey Joseph Schoenebeck, Dylan Neil Clements, Susan Mary Campbell, Donna Elaine Gaylor, Richard J Mellanby, Adam George Gow, Mazdak Salavati. Lactulose drives a reversible reduction and qualitative modulation of the faecal microbiota diversity in healthy dogs.
Scientific reports.
2019 09; 9(1):13350. doi:
10.1038/s41598-019-50090-7. [PMID: 31527716] - Buyi Zhang, Meghan L Verne, Jeremy Z Fields, G Nicholas Verne, QiQi Zhou. Intestinal Hyperpermeability in Gulf War Veterans With Chronic Gastrointestinal Symptoms.
Journal of clinical gastroenterology.
2019 08; 53(7):e298-e302. doi:
10.1097/mcg.0000000000001135. [PMID: 30260809] - Y Sakai, N Seki, K Hamano, H Ochi, F Abe, K Masuda, H Iino. Prebiotic effect of two grams of lactulose in healthy Japanese women: a randomised, double-blind, placebo-controlled crossover trial.
Beneficial microbes.
2019 Jul; 10(6):629-639. doi:
10.3920/bm2018.0174. [PMID: 31131617] - Zheng Zhang, Xiao Chen, Jiangtao Zhao, Changyu Tian, Xiao Wei, Huan Li, Weishi Lin, Aimin Jiang, Ruo Feng, Jing Yuan, Xiangna Zhao. Effects of a Lactulose-Rich Diet on Fecal Microbiome and Metabolome in Pregnant Mice.
Journal of agricultural and food chemistry.
2019 Jul; 67(27):7674-7683. doi:
10.1021/acs.jafc.9b01479. [PMID: 31132256] - Ying-Chi Shen, Ya-Hui Chang, Ching-Ju Fang, Yang-Sheng Lin. Zinc supplementation in patients with cirrhosis and hepatic encephalopathy: a systematic review and meta-analysis.
Nutrition journal.
2019 07; 18(1):34. doi:
10.1186/s12937-019-0461-3. [PMID: 31279342] - Miyu Sueyoshi, Masaki Fukunaga, Mizue Mei, Atsushi Nakajima, Gaku Tanaka, Takayo Murase, Yuki Narita, Sumio Hirata, Daisuke Kadowaki. Effects of lactulose on renal function and gut microbiota in adenine-induced chronic kidney disease rats.
Clinical and experimental nephrology.
2019 Jul; 23(7):908-919. doi:
10.1007/s10157-019-01727-4. [PMID: 30895529] - Stephanie A Richard, Benjamin J J McCormick, Laura E Murray-Kolb, Gwyneth O Lee, Jessica C Seidman, Mustafa Mahfuz, Tahmeed Ahmed, Richard L Guerrant, William A Petri, Elizabeth T Rogawski, Eric Houpt, Gagandeep Kang, Estomih Mduma, Margaret N Kosek, Aldo A M Lima, Sanjaya K Shrestha, Ram K Chandyo, Zulfiqar Bhutta, Pascal Bessong, Laura E Caulfield. Enteric dysfunction and other factors associated with attained size at 5 years: MAL-ED birth cohort study findings.
The American journal of clinical nutrition.
2019 07; 110(1):131-138. doi:
10.1093/ajcn/nqz004. [PMID: 31127812] - Jie Zeng, Mengdi Song, Tian Jia, Haiyan Gao, Ruiyao Zhang, Jikai Jiang. Immunomodulatory influences of sialylated lactuloses in mice.
Biochemical and biophysical research communications.
2019 06; 514(2):351-357. doi:
10.1016/j.bbrc.2019.04.157. [PMID: 31040021] - Prasenjit Mondal, Julie M Long, Jamie E Westcott, M Munirul Islam, Mondar Ahmed, Mustafa Mahfuz, Tahmeed Ahmed, Leland V Miller, Nancy F Krebs. Zinc Absorption and Endogenous Fecal Zinc Losses in Bangladeshi Toddlers at Risk for Environmental Enteric Dysfunction.
Journal of pediatric gastroenterology and nutrition.
2019 06; 68(6):874-879. doi:
10.1097/mpg.0000000000002361. [PMID: 31033623] - Namrata Singh, Ujjwal Sonika, Praneeth Moka, Brij Sharma, Vikas Sachdev, Sushil Kumar Mishra, Ashish Datt Upadhyay, Anoop Saraya. Association of endotoxaemia & gut permeability with complications of acute pancreatitis: Secondary analysis of data.
The Indian journal of medical research.
2019 06; 149(6):763-770. doi:
10.4103/ijmr.ijmr_763_17. [PMID: 31496529] - Eric T Hostnik, Valerie J Parker, John M Cullen. Computed Tomography of Lobular Dissecting Hepatitis in a Young Golden Retriever.
Journal of the American Animal Hospital Association.
2019 Mar; 55(2):e55203. doi:
10.5326/jaaha-ms-6867. [PMID: 30653361] - Md Abu Musa, Mamun Kabir, Md Iqbal Hossain, Emtiaz Ahmed, Abdullah Siddique, Humaira Rashid, Mustafa Mahfuz, Dinesh Mondal, Tahmeed Ahmed, William A Petri, Rashidul Haque. Measurement of intestinal permeability using lactulose and mannitol with conventional five hours and shortened two hours urine collection by two different methods: HPAE-PAD and LC-MSMS.
PloS one.
2019; 14(8):e0220397. doi:
10.1371/journal.pone.0220397. [PMID: 31393913] - Christian Schulz, Kerstin Schütte, Ramiro Vilchez-Vargas, Riccardo Vasapolli, Peter Malfertheiner. Long-Term Effect of Rifaximin with and without Lactulose on the Active Bacterial Assemblages in the Proximal Small Bowel and Faeces in Patients with Minimal Hepatic Encephalopathy.
Digestive diseases (Basel, Switzerland).
2019; 37(2):161-169. doi:
10.1159/000494216. [PMID: 30428474] - Khrystyna B Kvit, Natalya V Kharchenko, Vyacheslav V Kharchenko, Olga I Chornenka, Romania I Chornovus, Uljana S Dorofeeva, Oksana B Draganchuk, Oksana M Slaba. The role of small intestinal bacterial overgrowth in the pathogenesis of hyperlipidemia.
Wiadomosci lekarskie (Warsaw, Poland : 1960).
2019; 72(4):645-649. doi:
10.36740/wlek201904127. [PMID: 31055549] - Arijit Nath, Máté András Molnár, Attila Csighy, Kornélia Kőszegi, Ildikó Galambos, Klára Pásztorné Huszár, András Koris, Gyula Vatai. Biological Activities of Lactose-Based Prebiotics and Symbiosis with Probiotics on Controlling Osteoporosis, Blood-Lipid and Glucose Levels.
Medicina (Kaunas, Lithuania).
2018 Dec; 54(6):. doi:
10.3390/medicina54060098. [PMID: 30513975] - Yuan Cao, Shi-Ming Liu. Lactulose for the treatment of Chinese children with chronic constipation: A randomized controlled trial.
Medicine.
2018 Dec; 97(52):e13794. doi:
10.1097/md.0000000000013794. [PMID: 30593164] - Shixiang Zhai, Limeng Zhu, Song Qin, Lili Li. Effect of lactulose intervention on gut microbiota and short chain fatty acid composition of C57BL/6J mice.
MicrobiologyOpen.
2018 12; 7(6):e00612. doi:
10.1002/mbo3.612. [PMID: 29575825] - Michele Linsalata, Giuseppe Riezzo, Benedetta D'Attoma, Caterina Clemente, Antonella Orlando, Francesco Russo. Noninvasive biomarkers of gut barrier function identify two subtypes of patients suffering from diarrhoea predominant-IBS: a case-control study.
BMC gastroenterology.
2018 Nov; 18(1):167. doi:
10.1186/s12876-018-0888-6. [PMID: 30400824] - Xiao-Jun Cai, Lei Wang, Chun-Mei Hu. Efficacy of different drugs in the treatment of minimal hepatic encephalopathy: A network meta-analysis involving 826 patients based on 10 randomized controlled trials.
Journal of cellular biochemistry.
2018 11; 119(10):8336-8345. doi:
10.1002/jcb.26886. [PMID: 29932239] - Jacopo Gervasoni, Aniello Primiano, Cristina Graziani, Franco Scaldaferri, Antonio Gasbarrini, Andrea Urbani, Silvia Persichilli. Validation of UPLC-MS/MS Method for Determination of Urinary Lactulose/Mannitol.
Molecules (Basel, Switzerland).
2018 Oct; 23(10):. doi:
10.3390/molecules23102705. [PMID: 30347792] - Sarah Stryeck, Angela Horvath, Bettina Leber, Vanessa Stadlbauer, Tobias Madl. NMR spectroscopy enables simultaneous quantification of carbohydrates for diagnosis of intestinal and gastric permeability.
Scientific reports.
2018 10; 8(1):14650. doi:
10.1038/s41598-018-33104-8. [PMID: 30279548] - Marianne S Morseth, Tor A Strand, Liv Elin Torheim, Ram K Chandyo, Manjeswori Ulak, Sanjaya K Shrestha, Binob Shrestha, Sigrun Henjum. Nutrient intake and environmental enteric dysfunction among Nepalese children 9-24 months old-the MAL-ED birth cohort study.
Pediatric research.
2018 10; 84(4):509-515. doi:
10.1038/s41390-018-0108-7. [PMID: 30030503] - Jacqueline M Lauer, Christopher P Duggan, Lynne M Ausman, Jeffrey K Griffiths, Patrick Webb, Edgar Agaba, Nathan Nshakira, Hao Q Tran, Andrew T Gewirtz, Shibani Ghosh. Biomarkers of maternal environmental enteric dysfunction are associated with shorter gestation and reduced length in newborn infants in Uganda.
The American journal of clinical nutrition.
2018 10; 108(4):889-896. doi:
10.1093/ajcn/nqy176. [PMID: 30247538] - Uday C Ghoshal, Deepakshi Srivastava, Asha Misra. A randomized double-blind placebo-controlled trial showing rifaximin to improve constipation by reducing methane production and accelerating colon transit: A pilot study.
Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology.
2018 Sep; 37(5):416-423. doi:
10.1007/s12664-018-0901-6. [PMID: 30406392] - Weijiang Zheng, Xu Ji, Qing Zhang, Wenchao Du, Quanwei Wei, Wen Yao. Hydrogen-Rich Water and Lactulose Protect Against Growth Suppression and Oxidative Stress in Female Piglets Fed Fusarium Toxins Contaminated Diets.
Toxins.
2018 06; 10(6):. doi:
10.3390/toxins10060228. [PMID: 29867031] - S Gilani, G S Howarth, C D Tran, R Barekatain, S M Kitessa, R E A Forder, R J Hughes. Reduced fasting periods increase intestinal permeability in chickens.
Journal of animal physiology and animal nutrition.
2018 Feb; 102(1):e486-e492. doi:
10.1111/jpn.12712. [PMID: 28447376] - Sandra Y Wotzka, Markus Kreuzer, Lisa Maier, Mirjam Zünd, Markus Schlumberger, Bidong Nguyen, Mark Fox, Daniel Pohl, Henriette Heinrich, Gerhard Rogler, Luc Biedermann, Michael Scharl, Shinichi Sunagawa, Wolf-Dietrich Hardt, Benjamin Misselwitz. Microbiota stability in healthy individuals after single-dose lactulose challenge-A randomized controlled study.
PloS one.
2018; 13(10):e0206214. doi:
10.1371/journal.pone.0206214. [PMID: 30359438] - Dirk Hsm Schellekens, Inca Hr Hundscheid, Claire Aji Leenarts, Joep Grootjans, Kaatje Lenaerts, Wim A Buurman, Cornelis Hc Dejong, Joep Pm Derikx. Human small intestine is capable of restoring barrier function after short ischemic periods.
World journal of gastroenterology.
2017 Dec; 23(48):8452-8464. doi:
10.3748/wjg.v23.i48.8452. [PMID: 29358855] - Natália Ferreira Mendes, Flora França Nogueira Mariotti, José Simões de Andrade, Milena de Barros Viana, Isabel Cristina Céspedes, Márcia Regina Nagaoka, Luciana Le Sueur-Maluf. Lactulose decreases neuronal activation and attenuates motor behavioral deficits in hyperammonemic rats.
Metabolic brain disease.
2017 Dec; 32(6):2073-2083. doi:
10.1007/s11011-017-0098-x. [PMID: 28875419] - Kevin B Stephenson, Sophia E Agapova, Oscar Divala, Yankho Kaimila, Kenneth M Maleta, Chrissie Thakwalakwa, M Isabel Ordiz, Indi Trehan, Mark J Manary. Complementary feeding with cowpea reduces growth faltering in rural Malawian infants: a blind, randomized controlled clinical trial.
The American journal of clinical nutrition.
2017 Dec; 106(6):1500-1507. doi:
10.3945/ajcn.117.160986. [PMID: 29092882] - Aditya Narayan Sarangi, Amit Goel, Ankur Singh, Avani Sasi, Rakesh Aggarwal. Faecal bacterial microbiota in patients with cirrhosis and the effect of lactulose administration.
BMC gastroenterology.
2017 Nov; 17(1):125. doi:
10.1186/s12876-017-0683-9. [PMID: 29179682] - Ana de Lorenzo-Pinto, Raquel García-Sánchez, Almudena Lorenzo-Salinas. Lactulose enemas in the treatment of hepatic encephalopathy. Do we help or harm?.
Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva.
2017 Oct; 109(10):736-737. doi:
10.17235/reed.2017.5106/2017. [PMID: 28929776] - Naoyuki Fujimori, Michiharu Komatsu, Naoki Tanaka, Mai Iwaya, Hajime Nakano, Ayumi Sugiura, Tomoo Yamazaki, Soichiro Shibata, Yugo Iwaya, Takashi Muraki, Yuki Ichikawa, Takefumi Kimura, Satoru Joshita, Takeji Umemura, Akihiro Matsumoto, Eiji Tanaka. Cimetidine/lactulose therapy ameliorates erythropoietic protoporphyria-related liver injury.
Clinical journal of gastroenterology.
2017 Oct; 10(5):452-458. doi:
10.1007/s12328-017-0760-1. [PMID: 28676994] - S Gilani, G S Howarth, S M Kitessa, C D Tran, R E A Forder, R J Hughes. New biomarkers for increased intestinal permeability induced by dextran sodium sulphate and fasting in chickens.
Journal of animal physiology and animal nutrition.
2017 Oct; 101(5):e237-e245. doi:
10.1111/jpn.12596. [PMID: 27730676] - Jamie N Pugh, Samuel G Impey, Dominic A Doran, Simon C Fleming, James P Morton, Graeme L Close. Acute high-intensity interval running increases markers of gastrointestinal damage and permeability but not gastrointestinal symptoms.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.
2017 Sep; 42(9):941-947. doi:
10.1139/apnm-2016-0646. [PMID: 28511020] - George V Tetz, Kelly V Ruggles, Hua Zhou, Adriana Heguy, Aristotelis Tsirigos, Victor Tetz. Bacteriophages as potential new mammalian pathogens.
Scientific reports.
2017 08; 7(1):7043. doi:
10.1038/s41598-017-07278-6. [PMID: 28765534] - Kiran Ahire, Archana Sonawale. Comparison of Rifaximin Plus Lactulose with the Lactulose Alone for the Treatment of Hepatic Encephalopathy.
The Journal of the Association of Physicians of India.
2017 Aug; 65(8):42-46. doi:
NULL. [PMID: 28799305] - Ganesh Pantham, Anthony Post, Deepak Venkat, Douglas Einstadter, Kevin D Mullen. A New Look at Precipitants of Overt Hepatic Encephalopathy in Cirrhosis.
Digestive diseases and sciences.
2017 08; 62(8):2166-2173. doi:
10.1007/s10620-017-4630-y. [PMID: 28560484] - S Gilani, G S Howarth, S M Kitessa, C D Tran, R E A Forder, R J Hughes. Intestinal permeability induced by lipopolysaccharide and measured by lactulose, rhamnose and mannitol sugars in chickens.
Animal : an international journal of animal bioscience.
2017 Jul; 11(7):1174-1179. doi:
10.1017/s1751731116002470. [PMID: 27881199] - Keith McIntosh, David E Reed, Theresa Schneider, Frances Dang, Ammar H Keshteli, Giada De Palma, Karen Madsen, Premysl Bercik, Stephen Vanner. FODMAPs alter symptoms and the metabolome of patients with IBS: a randomised controlled trial.
Gut.
2017 07; 66(7):1241-1251. doi:
10.1136/gutjnl-2015-311339. [PMID: 26976734] - Q-X Shen, G-X Xu, M-H Shen. Effect of early enteral nutrition (EN) on endotoxin in serum and intestinal permeability in patients with severe acute pancreatitis.
European review for medical and pharmacological sciences.
2017 06; 21(11):2764-2768. doi:
NULL. [PMID: 28678307] - Stephanie A Peters, Shoko Edogawa, Wendy J Sundt, Roy B Dyer, Daniel A Dalenberg, Amelia Mazzone, Ravinder J Singh, Natalie Moses, Thomas C Smyrk, Christopher Weber, David R Linden, Wallace K MacNaughton, Jerrold R Turner, Michael Camilleri, David A Katzka, Gianrico Farrugia, Madhusudan Grover. Constipation-Predominant Irritable Bowel Syndrome Females Have Normal Colonic Barrier and Secretory Function.
The American journal of gastroenterology.
2017 Jun; 112(6):913-923. doi:
10.1038/ajg.2017.48. [PMID: 28323272] - Lyu Wang, Yun-Liang Cui, Zhe Zhang, Zhao-Fen Lin, De-Chang Chen. Rhubarb Monomers Protect Intestinal Mucosal Barrier in Sepsis via Junction Proteins.
Chinese medical journal.
2017 May; 130(10):1218-1225. doi:
10.4103/0366-6999.205855. [PMID: 28485323] - Daniel S March, Tania Marchbank, Raymond J Playford, Arwel W Jones, Rhys Thatcher, Glen Davison. Intestinal fatty acid-binding protein and gut permeability responses to exercise.
European journal of applied physiology.
2017 May; 117(5):931-941. doi:
10.1007/s00421-017-3582-4. [PMID: 28290057] - Mozhgan Ghobadi Pour, Naser Mirazi, Hojjatollah Alaei, Shirin Moradkhani, Ziba Rajaei, Alireza Monsef Esfahani. Effects of lactulose and silymarin on liver enzymes in cirrhotic rats.
Canadian journal of physiology and pharmacology.
2017 May; 95(5):522-529. doi:
10.1139/cjpp-2016-0454. [PMID: 28281782] - Ujjwal Sonika, Pooja Goswami, Bhaskar Thakur, Rajni Yadav, Prasenjit Das, Vineet Ahuja, Anoop Saraya. Mechanism of Increased Intestinal Permeability in Acute Pancreatitis: Alteration in Tight Junction Proteins.
Journal of clinical gastroenterology.
2017 May; 51(5):461-466. doi:
10.1097/mcg.0000000000000612. [PMID: 27466164] - Jieyuan Wu, Peixia Jiang, Wei Chen, Dandan Xiong, Linglan Huang, Junying Jia, Yuanyuan Chen, Jian-Ming Jin, Shuang-Yan Tang. Design and application of a lactulose biosensor.
Scientific reports.
2017 04; 7(?):45994. doi:
10.1038/srep45994. [PMID: 28387245] - Margaret N Kosek. Causal Pathways from Enteropathogens to Environmental Enteropathy: Findings from the MAL-ED Birth Cohort Study.
EBioMedicine.
2017 Apr; 18(?):109-117. doi:
10.1016/j.ebiom.2017.02.024. [PMID: 28396264] - Dinesh Kumar, Gaurav Pandey, Deepak Bansal, Atul Rawat, Umesh Kumar, Durgesh Dubey, Anupam Guleria, Vivek Anand Saraswat. NMR-based urinary profiling of lactulose/mannitol ratio used to assess the altered intestinal permeability in acute on chronic liver failure (ACLF) patients.
Magnetic resonance in chemistry : MRC.
2017 Apr; 55(4):289-296. doi:
10.1002/mrc.4525. [PMID: 27623987] - Maria Chiara Buscarinu, Benedetta Cerasoli, Viviana Annibali, Claudia Policano, Luana Lionetto, Matilde Capi, Rosella Mechelli, Silvia Romano, Arianna Fornasiero, Gianluca Mattei, Eleonora Piras, Daniela Francesca Angelini, Luca Battistini, Maurizio Simmaco, Renato Umeton, Marco Salvetti, Giovanni Ristori. Altered intestinal permeability in patients with relapsing-remitting multiple sclerosis: A pilot study.
Multiple sclerosis (Houndmills, Basingstoke, England).
2017 Mar; 23(3):442-446. doi:
10.1177/1352458516652498. [PMID: 27270497] - Rohan Dalal, Richard G McGee, Stephen M Riordan, Angela C Webster. Probiotics for people with hepatic encephalopathy.
The Cochrane database of systematic reviews.
2017 02; 2(?):CD008716. doi:
10.1002/14651858.cd008716.pub3. [PMID: 28230908] - Francesco Russo, Guglielmina Chimienti, Michele Linsalata, Caterina Clemente, Antonella Orlando, Giuseppe Riezzo. The obestatin/ghrelin ratio and ghrelin genetics in adult celiac patients before and after a gluten-free diet, in irritable bowel syndrome patients and healthy individuals.
European journal of gastroenterology & hepatology.
2017 Feb; 29(2):160-168. doi:
10.1097/meg.0000000000000760. [PMID: 27750262] - Alba Moratalla, Javier Ampuero, Pablo Bellot, Rocío Gallego-Durán, Pedro Zapater, Manuela Roger, Blanca Figueruela, Belén Martínez-Moreno, José M González-Navajas, José Such, Manuel Romero-Gómez, Rubén Francés. Lactulose reduces bacterial DNA translocation, which worsens neurocognitive shape in cirrhotic patients with minimal hepatic encephalopathy.
Liver international : official journal of the International Association for the Study of the Liver.
2017 02; 37(2):212-223. doi:
10.1111/liv.13200. [PMID: 27388776] - Lonneke M JanssenDuijghuijsen, Klaske van Norren, Sander Grefte, Stef J Koppelman, Kaatje Lenaerts, Jaap Keijer, Renger F Witkamp, Harry J Wichers. Endurance Exercise Increases Intestinal Uptake of the Peanut Allergen Ara h 6 after Peanut Consumption in Humans.
Nutrients.
2017 Jan; 9(1):. doi:
10.3390/nu9010084. [PMID: 28117717] - Takayuki Kato, Yasushi Honda, Yusuke Kurita, Akito Iwasaki, Takamitsu Sato, Takaomi Kessoku, Shiori Uchiyama, Yuji Ogawa, Hidenori Ohkubo, Takuma Higurashi, Takeharu Yamanaka, Haruki Usuda, Koichiro Wada, Atsushi Nakajima. Lubiprostone improves intestinal permeability in humans, a novel therapy for the leaky gut: A prospective randomized pilot study in healthy volunteers.
PloS one.
2017; 12(4):e0175626. doi:
10.1371/journal.pone.0175626. [PMID: 28410406] - P Chassagne, P Ducrotte, P Garnier, H Mathiex-Fortunet. Tolerance and Long-Term Efficacy of Polyethylene Glycol 4000 (Forlax®) Compared to Lactulose in Elderly Patients with Chronic Constipation.
The journal of nutrition, health & aging.
2017; 21(4):429-439. doi:
10.1007/s12603-016-0762-6. [PMID: 28346570] - Lonneke M JanssenDuijghuijsen, Jaap Keijer, Marco Mensink, Kaatje Lenaerts, Lars Ridder, Stefan Nierkens, Shirley W Kartaram, Martie C M Verschuren, Raymond H H Pieters, Richard Bas, Renger F Witkamp, Harry J Wichers, Klaske van Norren. Adaptation of exercise-induced stress in well-trained healthy young men.
Experimental physiology.
2017 01; 102(1):86-99. doi:
10.1113/ep086025. [PMID: 27808433]