Hippuric acid (BioDeep_00000398603)

Main id: BioDeep_00000017814

Secondary id: BioDeep_00000001350, BioDeep_00000400001

PANOMIX_OTCML-2023


代谢物信息卡片


2-BENZAMIDOACETIC ACID

化学式: C9H9NO3 (179.05824040000002)
中文名称: 2-苯酰胺乙酸, 马尿酸, 马尿酸
谱图信息: 最多检出来源 Homo sapiens(blood) 0.28%

分子结构信息

SMILES: C1=CC=C(C=C1)C(=O)NCC(=O)O
InChI: InChI=1S/C9H9NO3/c11-8(12)6-10-9(13)7-4-2-1-3-5-7/h1-5H,6H2,(H,10,13)(H,11,12)

描述信息

C254 - Anti-Infective Agent > C255 - Urinary Anti-Infective Agent
An N-acylglycine in which the acyl group is specified as benzoyl.
MS2 deconvoluted using MS2Dec from all ion fragmentation data, MetaboLights identifier MTBLS1040; QIAFMBKCNZACKA-UHFFFAOYSA-N_STSL_0191_Hippuric acid_2000fmol_180831_S2_L02M02_62; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
MS2 deconvoluted using CorrDec from all ion fragmentation data, MetaboLights identifier MTBLS1040; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.317
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.318
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.315
Hippuric Acid (2-Benzamidoacetic acid), an acyl glycine produced by the conjugation of benzoic acid and glycine, is a normal component in urine as a metabolite of aromatic compounds from food.
Hippuric Acid (2-Benzamidoacetic acid), an acyl glycine produced by the conjugation of benzoic acid and glycine, is a normal component in urine as a metabolite of aromatic compounds from food.

同义名列表

4 个代谢物同义名

2-BENZAMIDOACETIC ACID; N-Benzoylglycine; Hippuric acid; Benzoylglycine



数据库引用编号

64 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

6 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Mansooreh Dehghani, Alireza Abbasi, Ziba Taherzadeh, Samaneh Dehghani. Exposure assessment of wastewater treatment plant employees to BTEX: a biological monitoring approach. Scientific reports. 2022 12; 12(1):21433. doi: 10.1038/s41598-022-25876-x. [PMID: 36509850]
  • Giulia De Simone, Claudia Balducci, Gianluigi Forloni, Roberta Pastorelli, Laura Brunelli. Hippuric acid: Could became a barometer for frailty and geriatric syndromes?. Ageing research reviews. 2021 12; 72(?):101466. doi: 10.1016/j.arr.2021.101466. [PMID: 34560280]
  • Laura Brunelli, Annalisa Davin, Giovanna Sestito, Maria Chiara Mimmi, Giulia De Simone, Claudia Balducci, Orietta Pansarasa, Gianluigi Forloni, Cristina Cereda, Roberta Pastorelli, Antonio Guaita. Plasmatic Hippuric Acid as a Hallmark of Frailty in an Italian Cohort: The Mediation Effect of Fruit-Vegetable Intake. The journals of gerontology. Series A, Biological sciences and medical sciences. 2021 11; 76(12):2081-2089. doi: 10.1093/gerona/glab244. [PMID: 34436596]
  • Robert D Mair, Seolhyun Lee, Natalie S Plummer, Tammy L Sirich, Timothy W Meyer. Impaired Tubular Secretion of Organic Solutes in Advanced Chronic Kidney Disease. Journal of the American Society of Nephrology : JASN. 2021 11; 32(11):2877-2884. doi: 10.1681/asn.2021030336. [PMID: 34408065]
  • Xiaoyue Shan, Lei Zhang, Haipeng Ye, Ji Shao, Yanpeng Shi, Siwei Tan, Ling Zhang, Kewen Su. Analytical techniques for monitoring of toluene and xylene exposure biomarkers hippuric acid and methylhippuric acid in human urine samples. Bioanalysis. 2021 Oct; 13(20):1569-1584. doi: 10.4155/bio-2021-0180. [PMID: 34696600]
  • Klaudia Dymek, Grzegorz Kurowski, Łukasz Kuterasiński, Roman Jędrzejczyk, Magdalena Szumera, Maciej Sitarz, Anna Pajdak, Łukasz Kurach, Anna Boguszewska-Czubara, Przemysław J Jodłowski. In Search of Effective UiO-66 Metal-Organic Frameworks for Artificial Kidney Application. ACS applied materials & interfaces. 2021 Sep; 13(38):45149-45160. doi: 10.1021/acsami.1c05972. [PMID: 34520182]
  • Jingjing Han, Huiqi Wang, Zhanfeng Li, Zonghua Wang. Preparation of chitosan-modified magnetic Schiff base network composite nanospheres for effective enrichment and detection of hippuric acid and 4-methyl hippuric acid. Journal of chromatography. A. 2021 Aug; 1652(?):462373. doi: 10.1016/j.chroma.2021.462373. [PMID: 34246963]
  • Chaw Ei Htwe Maung, Hyung Gwon Lee, Jeong-Yong Cho, Kil Yong Kim. Antifungal compound, methyl hippurate from Bacillus velezensis CE 100 and its inhibitory effect on growth of Botrytis cinerea. World journal of microbiology & biotechnology. 2021 Aug; 37(9):159. doi: 10.1007/s11274-021-03046-x. [PMID: 34420104]
  • Chun-Hui Chiu, Chi-Tsung Chen, Ming-Huei Cheng, Li-Heng Pao, Chi Wang, Gwo-Hwa Wan. Use of urinary hippuric acid and o-/p-/m-methyl hippuric acid to evaluate surgical smoke exposure in operating room healthcare personnel. Ecotoxicology and environmental safety. 2021 Jul; 217(?):112231. doi: 10.1016/j.ecoenv.2021.112231. [PMID: 33862429]
  • Yung-Chuan Lu, Cheng-Ching Wu, I-Ting Tsai, Wei-Chin Hung, Thung-Lip Lee, Chin-Feng Hsuan, Teng-Hung Yu, Ching-Ting Wei, Fu-Mei Chung, Yau-Jiunn Lee, Chao-Ping Wang. Associations among total p-cresylsulfate, indoxyl sulfate and hippuric acid levels with hemodialysis quality indicators in maintenance hemodialysis patients. Clinica chimica acta; international journal of clinical chemistry. 2021 May; 516(?):83-91. doi: 10.1016/j.cca.2021.01.015. [PMID: 33508250]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Kamil Łuczykowski, Natalia Warmuzińska, Sylwia Operacz, Iga Stryjak, Joanna Bogusiewicz, Julia Jacyna, Renata Wawrzyniak, Wiktoria Struck-Lewicka, Michał J Markuszewski, Barbara Bojko. Metabolic Evaluation of Urine from Patients Diagnosed with High Grade (HG) Bladder Cancer by SPME-LC-MS Method. Molecules (Basel, Switzerland). 2021 Apr; 26(8):. doi: 10.3390/molecules26082194. [PMID: 33920347]
  • Muzamil Ahmad Rather, Kuldeep Gupta, Manabendra Mandal. Inhibition of biofilm and quorum sensing-regulated virulence factors in Pseudomonas aeruginosa by Cuphea carthagenensis (Jacq.) J. F. Macbr. Leaf extract: An in vitro study. Journal of ethnopharmacology. 2021 Apr; 269(?):113699. doi: 10.1016/j.jep.2020.113699. [PMID: 33340600]
  • Young-Sun Min, Sungho Lee, Mingi Kim, Yeon-Soon Ahn. Rheumatoid arthritis in low-level toluene-exposed workers based on nationwide medical surveillance data in Korea. American journal of industrial medicine. 2021 04; 64(4):245-250. doi: 10.1002/ajim.23226. [PMID: 33512020]
  • Yan Ren, Zhen-Zhu Chen, Xiao-Li Sun, Hui-Jun Duan, Jun-Sheng Tian, Jia-Ying Wang, Hong Yang. Metabolomic analysis to detect urinary molecular changes associated with bipolar depression. Neuroscience letters. 2021 01; 742(?):135515. doi: 10.1016/j.neulet.2020.135515. [PMID: 33227370]
  • Jiao-Jiao Zhao, Lei Zhang, Peng-Yu Liu, Wei-Zhe Chen, Zhi-Liang Liu, Yan-Qin Wang. Water-stable Cd(ii)/Zn(ii) coordination polymers as recyclable luminescent sensors for detecting hippuric acid in simulated urine for indexing toluene exposure with high selectivity, sensitivity and fast response. Dalton transactions (Cambridge, England : 2003). 2021 Jan; 50(2):553-561. doi: 10.1039/d0dt03648j. [PMID: 33350995]
  • Jin-Ran Chen, Haijun Zhao, Umesh D Wankhade, Sree V Chintapalli, Can Li, Dongzheng Gai, Kartik Shankar, Fenghuang Zhan, Oxana P Lazarenko. GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice. Communications biology. 2021 01; 4(1):53. doi: 10.1038/s42003-020-01564-2. [PMID: 33420329]
  • Abdullah Basoglu, Nuri Baspinar, Leonardo Tenori, Cristina Licari, Erdem Gulersoy. Nuclear magnetic resonance (NMR)-based metabolome profile evaluation in dairy cows with and without displaced abomasum. The veterinary quarterly. 2020 Dec; 40(1):1-15. doi: 10.1080/01652176.2019.1707907. [PMID: 31858882]
  • Erin D Clarke, Megan E Rollo, Clare E Collins, Lisa Wood, Robin Callister, Mark Philo, Paul A Kroon, Rebecca L Haslam. The Relationship between Dietary Polyphenol Intakes and Urinary Polyphenol Concentrations in Adults Prescribed a High Vegetable and Fruit Diet. Nutrients. 2020 Nov; 12(11):. doi: 10.3390/nu12113431. [PMID: 33182344]
  • Ivana Stanimirova, Mirosław Banasik, Adam Ząbek, Tomasz Dawiskiba, Katarzyna Kościelska-Kasprzak, Wojciech Wojtowicz, Magdalena Krajewska, Dariusz Janczak, Piotr Młynarz. Serum metabolomics approach to monitor the changes in metabolite profiles following renal transplantation. Scientific reports. 2020 10; 10(1):17223. doi: 10.1038/s41598-020-74245-z. [PMID: 33057167]
  • Camille André, Youssef Bennis, Dimitri Titeca-Beauport, Pauline Caillard, Yan Cluet, Said Kamel, Gabriel Choukroun, Julien Maizel, Sophie Liabeuf, Sandra Bodeau. Two rapid, accurate liquid chromatography tandem mass spectrometry methods for the quantification of seven uremic toxins: An application for describing their accumulation kinetic profile in a context of acute kidney injury. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2020 Sep; 1152(?):122234. doi: 10.1016/j.jchromb.2020.122234. [PMID: 32615535]
  • Michael R Duff, Scott A Gabel, Lars C Pedersen, Eugene F DeRose, Juno M Krahn, Elizabeth E Howell, Robert E London. The Structural Basis for Nonsteroidal Anti-Inflammatory Drug Inhibition of Human Dihydrofolate Reductase. Journal of medicinal chemistry. 2020 08; 63(15):8314-8324. doi: 10.1021/acs.jmedchem.0c00546. [PMID: 32658475]
  • Aparna Nerusu, Papa Rao Vaikuntapu, Dinesh Kumar Chinthapalli, Appa Rao Podile, Rajagopal Subramanyam. Truncated domains of human serum albumin improves the binding efficiency of uremic toxins: A surface plasmon resonance and computational approach. International journal of biological macromolecules. 2020 Jul; 155(?):1216-1225. doi: 10.1016/j.ijbiomac.2019.11.089. [PMID: 31734369]
  • Dennis P Cladis, Hawi Debelo, Pamela J Lachcik, Mario G Ferruzzi, Connie M Weaver. Increasing Doses of Blueberry Polyphenols Alters Colonic Metabolism and Calcium Absorption in Ovariectomized Rats. Molecular nutrition & food research. 2020 06; 64(12):e2000031. doi: 10.1002/mnfr.202000031. [PMID: 32386352]
  • Ryusuke Hatae, Kenji Chamoto, Young Hak Kim, Kazuhiro Sonomura, Kei Taneishi, Shuji Kawaguchi, Hironori Yoshida, Hiroaki Ozasa, Yuichi Sakamori, Maryam Akrami, Sidonia Fagarasan, Izuru Masuda, Yasushi Okuno, Fumihiko Matsuda, Toyohiro Hirai, Tasuku Honjo. Combination of host immune metabolic biomarkers for the PD-1 blockade cancer immunotherapy. JCI insight. 2020 01; 5(2):. doi: 10.1172/jci.insight.133501. [PMID: 31855576]
  • Yi-Wen Huang, Chien-Wei Lin, Pan Pan, Tianjiao Shan, Carla Elena Echeveste, Yue Yang Mo, Hsin-Tzu Wang, Mohammed Aldakkak, Susan Tsai, Kiyoko Oshima, Martha Yearsley, Jianbo Xiao, Hui Cao, Chongde Sun, Ming Du, Weibin Bai, Jianhua Yu, Li-Shu Wang. Black Raspberries Suppress Colorectal Cancer by Enhancing Smad4 Expression in Colonic Epithelium and Natural Killer Cells. Frontiers in immunology. 2020; 11(?):570683. doi: 10.3389/fimmu.2020.570683. [PMID: 33424832]
  • Haijun Zhao, Oxana P Lazarenko, Jin-Ran Chen. Hippuric acid and 3-(3-hydroxyphenyl) propionic acid inhibit murine osteoclastogenesis through RANKL-RANK independent pathway. Journal of cellular physiology. 2020 01; 235(1):599-610. doi: 10.1002/jcp.28998. [PMID: 31271661]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Alexander J Prokopienko, Raymond E West, Jason R Stubbs, Thomas D Nolin. Development and validation of a UHPLC-MS/MS method for measurement of a gut-derived uremic toxin panel in human serum: An application in patients with kidney disease. Journal of pharmaceutical and biomedical analysis. 2019 Sep; 174(?):618-624. doi: 10.1016/j.jpba.2019.06.033. [PMID: 31276982]
  • Anisha Wijeyesekera, Josef Wagner, Marcus De Goffau, Sarah Thurston, Adilson Rodrigues Sabino, Sara Zaher, Deborah White, Jenna Ridout, Mark J Peters, Padmanabhan Ramnarayan, Ricardo G Branco, M Estee Torok, Frederic Valla, Rosan Meyer, Nigel Klein, Gary Frost, Julian Parkhill, Elaine Holmes, Nazima Pathan. Multi-Compartment Profiling of Bacterial and Host Metabolites Identifies Intestinal Dysbiosis and Its Functional Consequences in the Critically Ill Child. Critical care medicine. 2019 09; 47(9):e727-e734. doi: 10.1097/ccm.0000000000003841. [PMID: 31169619]
  • Xiao-Dong Sun, Hai-Long Wu, Zhi Liu, Yue Chen, Jun-Chen Chen, Li Cheng, Yu-Jie Ding, Ru-Qin Yu. Target-based metabolomics for fast and sensitive quantification of eight small molecules in human urine using HPLC-DAD and chemometrics tools resolving of highly overlapping peaks. Talanta. 2019 Aug; 201(?):174-184. doi: 10.1016/j.talanta.2019.03.090. [PMID: 31122409]
  • Asma Hasil, Arshad Mehmood, Maqsood Ahmed. Experimental and theoretical charge-density analysis of hippuric acid: insight into its binding with human serum albumin. Acta crystallographica Section B, Structural science, crystal engineering and materials. 2019 Aug; 75(Pt 4):750-762. doi: 10.1107/s2052520619007911. [PMID: 32830731]
  • Olivier Deltombe, Griet Glorieux, Sami Marzouki, Rosalinde Masereeuw, Daniel Schneditz, Sunny Eloot. Selective Transport of Protein-Bound Uremic Toxins in Erythrocytes. Toxins. 2019 07; 11(7):. doi: 10.3390/toxins11070385. [PMID: 31266243]
  • Yi-Ting Lin, Ping-Hsun Wu, Hei-Hwa Lee, Mwenya Mubanga, Cheng-Sheng Chen, Mei-Chuan Kuo, Yi-Wen Chiu, Po-Lin Kuo, Shang-Jyh Hwang. Indole-3 acetic acid increased risk of impaired cognitive function in patients receiving hemodialysis. Neurotoxicology. 2019 07; 73(?):85-91. doi: 10.1016/j.neuro.2019.02.019. [PMID: 30826344]
  • Cristina Román-Hidalgo, Germán López-Pérez, María Jesús Martín-Valero, Miguel Ángel Bello-López. Chitosan tailor-made membranes as biopolymeric support for electromembrane extraction. Talanta. 2019 Jul; 199(?):290-295. doi: 10.1016/j.talanta.2019.02.079. [PMID: 30952260]
  • Yuanyuan Shi, Yifeng Wang, Shuai Ma, Tingyan Liu, Huajun Tian, Qiuyu Zhu, Wenji Wang, Yulin Li, Feng Ding. Increasing the removal of protein-bound uremic toxins by liposome-supported hemodialysis. Artificial organs. 2019 May; 43(5):490-503. doi: 10.1111/aor.13383. [PMID: 30375673]
  • Peter L Voyvodic, Amir Pandi, Mathilde Koch, Ismael Conejero, Emmanuel Valjent, Philippe Courtet, Eric Renard, Jean-Loup Faulon, Jerome Bonnet. Plug-and-play metabolic transducers expand the chemical detection space of cell-free biosensors. Nature communications. 2019 04; 10(1):1697. doi: 10.1038/s41467-019-09722-9. [PMID: 30979906]
  • Karl M Weigand, Tom J J Schirris, Megan Houweling, Jeroen J M W van den Heuvel, Jan B Koenderink, Anita C A Dankers, Frans G M Russel, Rick Greupink. Uremic solutes modulate hepatic bile acid handling and induce mitochondrial toxicity. Toxicology in vitro : an international journal published in association with BIBRA. 2019 Apr; 56(?):52-61. doi: 10.1016/j.tiv.2019.01.003. [PMID: 30639138]
  • Angela Guerra, Andrea Ticinesi, Franca Allegri, Antonio Nouvenne, Beatrice Prati, Silvana Pinelli, Roberta Merli, Claudio Tana, Fulvio Lauretani, Rosalia Aloe, Loris Borghi, Tiziana Meschi. Insights about urinary hippuric and citric acid as biomarkers of fruit and vegetable intake in patients with kidney stones: The role of age and sex. Nutrition (Burbank, Los Angeles County, Calif.). 2019 03; 59(?):83-89. doi: 10.1016/j.nut.2018.07.112. [PMID: 30471528]
  • Michael Pignanelli, Chrysi Bogiatzi, Gregory Gloor, Emma Allen-Vercoe, Gregor Reid, Bradley L Urquhart, Kelsey N Ruetz, Thomas J Velenosi, J David Spence. Moderate Renal Impairment and Toxic Metabolites Produced by the Intestinal Microbiome: Dietary Implications. Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation. 2019 01; 29(1):55-64. doi: 10.1053/j.jrn.2018.05.007. [PMID: 30100156]
  • Shanmugakumar Chinnappa, Yu-Kang Tu, Yi Chun Yeh, Griet Glorieux, Raymond Vanholder, Andrew Mooney. Association between Protein-Bound Uremic Toxins and Asymptomatic Cardiac Dysfunction in Patients with Chronic Kidney Disease. Toxins. 2018 12; 10(12):. doi: 10.3390/toxins10120520. [PMID: 30563136]
  • Jian-Jun Chen, Shun-Jie Bai, Wen-Wen Li, Chan-Juan Zhou, Peng Zheng, Liang Fang, Hai-Yang Wang, Yi-Yun Liu, Peng Xie. Urinary biomarker panel for diagnosing patients with depression and anxiety disorders. Translational psychiatry. 2018 09; 8(1):192. doi: 10.1038/s41398-018-0245-0. [PMID: 30232320]
  • Teng-Hung Yu, Wei-Hua Tang, Yung-Chuan Lu, Chao-Ping Wang, Wei-Chin Hung, Cheng-Ching Wu, I-Ting Tsai, Fu-Mei Chung, Jer-Yiing Houng, Wen-Chun Lan, Yau-Jiunn Lee. Association between hippuric acid and left ventricular hypertrophy in maintenance hemodialysis patients. Clinica chimica acta; international journal of clinical chemistry. 2018 Sep; 484(?):47-51. doi: 10.1016/j.cca.2018.05.022. [PMID: 29758204]
  • Dorottya Nagy-Szakal, Dinesh K Barupal, Bohyun Lee, Xiaoyu Che, Brent L Williams, Ellie J R Kahn, Joy E Ukaigwe, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn, W Ian Lipkin. Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics. Scientific reports. 2018 07; 8(1):10056. doi: 10.1038/s41598-018-28477-9. [PMID: 29968805]
  • Sheldon C Leong, Justin N Sao, Abigail Taussig, Natalie S Plummer, Timothy W Meyer, Tammy L Sirich. Residual Function Effectively Controls Plasma Concentrations of Secreted Solutes in Patients on Twice Weekly Hemodialysis. Journal of the American Society of Nephrology : JASN. 2018 07; 29(7):1992-1999. doi: 10.1681/asn.2018010081. [PMID: 29728422]
  • Mengjie Huang, Ribao Wei, Yang Wang, Tingyu Su, Ping Li, Xiangmei Chen. The uremic toxin hippurate promotes endothelial dysfunction via the activation of Drp1-mediated mitochondrial fission. Redox biology. 2018 06; 16(?):303-313. doi: 10.1016/j.redox.2018.03.010. [PMID: 29573704]
  • Joy Leng, Chris Proudman, Alistair Darby, Frances Blow, Neil Townsend, Andrew Miller, Jonathan Swann. Exploration of the Fecal Microbiota and Biomarker Discovery in Equine Grass Sickness. Journal of proteome research. 2018 03; 17(3):1120-1128. doi: 10.1021/acs.jproteome.7b00784. [PMID: 29364680]
  • Román-Hidalgo Cristina, Martín-Valero María Jesús, Fernández-Torres Rut, Bello-López Miguel Ángel. Use of Polymer Inclusion Membranes (PIMs) as support for electromembrane extraction of non-steroidal anti-inflammatory drugs and highly polar acidic drugs. Talanta. 2018 Mar; 179(?):601-607. doi: 10.1016/j.talanta.2017.11.066. [PMID: 29310282]
  • Yaran Du, Xiqian Li, Haijiao Zheng, Xueju Lv, Qiong Jia. Design of a calix[4]arene-functionalized metal-organic framework probe for highly sensitive and selective monitor of hippuric acid for indexing toluene exposure. Analytica chimica acta. 2018 Feb; 1001(?):134-142. doi: 10.1016/j.aca.2017.11.039. [PMID: 29291796]
  • B Hipp, K-H Südekum, A Zeyner, G Goren, E Kienzle. Renal energy excretion of horses depends on renal hippuric acid and nitrogen excretion. Journal of animal physiology and animal nutrition. 2018 Feb; 102(1):e380-e386. doi: 10.1111/jpn.12756. [PMID: 28608590]
  • Abdulrahman Bahrami, Farhad Ghamari, Yadollah Yamini, Farshid Ghorbani Shahna, Ali Koolivand. Ion-pair-based hollow-fiber liquid-phase microextraction combined with high-performance liquid chromatography for the simultaneous determination of urinary benzene, toluene, and styrene metabolites. Journal of separation science. 2018 Jan; 41(2):501-508. doi: 10.1002/jssc.201700685. [PMID: 29082608]
  • Gregorio Peron, Davide Santarossa, Dario Voinovich, Stefano Dall'Acqua, Stefania Sut. Urine metabolomics shows an induction of fatty acids metabolism in healthy adult volunteers after supplementation with green coffee (Coffea robusta L.) bean extract. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 Jan; 38(?):74-83. doi: 10.1016/j.phymed.2017.11.002. [PMID: 29425657]
  • Chi Young Choi, NamJun Cho, Su Yeon Park, Samel Park, Hyo Wook Gil, Sae Yong Hong. Urine Methyl Hippuric Acid Levels in Acute Pesticide Poisoning: Estimation of Ingested Xylene Volume and Association with Clinical Outcome Parameters. Journal of Korean medical science. 2017 Dec; 32(12):2051-2057. doi: 10.3346/jkms.2017.32.12.2051. [PMID: 29115090]
  • Tariq Shafi, Tammy L Sirich, Timothy W Meyer, Thomas H Hostetter, Natalie S Plummer, Seungyoung Hwang, Michal L Melamed, Tanushree Banerjee, Josef Coresh, Neil R Powe. Results of the HEMO Study suggest that p-cresol sulfate and indoxyl sulfate are not associated with cardiovascular outcomes. Kidney international. 2017 12; 92(6):1484-1492. doi: 10.1016/j.kint.2017.05.012. [PMID: 28739139]
  • Morgan E Grams, Adrienne Tin, Casey M Rebholz, Tariq Shafi, Anna Köttgen, Ronald D Perrone, Mark J Sarnak, Lesley A Inker, Andrew S Levey, Josef Coresh. Metabolomic Alterations Associated with Cause of CKD. Clinical journal of the American Society of Nephrology : CJASN. 2017 Nov; 12(11):1787-1794. doi: 10.2215/cjn.02560317. [PMID: 28971980]
  • Rhiannon Bray, Stefano Cacciatore, Beatriz Jiménez, Rufus Cartwright, Alex Digesu, Ruwan Fernando, Elaine Holmes, Jeremy K Nicholson, Phillip R Bennett, David A MacIntyre, Vik Khullar. Urinary Metabolic Phenotyping of Women with Lower Urinary Tract Symptoms. Journal of proteome research. 2017 11; 16(11):4208-4216. doi: 10.1021/acs.jproteome.7b00568. [PMID: 28937771]
  • Lucía G Pruneda-Alvarez, Tania Ruíz-Vera, Angeles C Ochoa-Martínez, Iván N Pérez-Maldonado. Urinary trans-trans muconic acid (exposure biomarker to benzene) and hippuric acid (exposure biomarker to toluene) concentrations in Mexican women living in high-risk scenarios of air pollution. Archives of environmental & occupational health. 2017 Nov; 72(6):351-358. doi: 10.1080/19338244.2016.1272539. [PMID: 27982738]
  • D Pavlenko, D Giasafaki, G Charalambopoulou, E van Geffen, K G F Gerritsen, T Steriotis, D Stamatialis. Carbon Adsorbents With Dual Porosity for Efficient Removal of Uremic Toxins and Cytokines from Human Plasma. Scientific reports. 2017 11; 7(1):14914. doi: 10.1038/s41598-017-15116-y. [PMID: 29097715]
  • C Behr, H Kamp, E Fabian, G Krennrich, W Mellert, E Peter, V Strauss, T Walk, I M C M Rietjens, B van Ravenzwaay. Gut microbiome-related metabolic changes in plasma of antibiotic-treated rats. Archives of toxicology. 2017 Oct; 91(10):3439-3454. doi: 10.1007/s00204-017-1949-2. [PMID: 28337503]
  • Linda H Münger, Alessia Trimigno, Gianfranco Picone, Carola Freiburghaus, Grégory Pimentel, Kathryn J Burton, François P Pralong, Nathalie Vionnet, Francesco Capozzi, René Badertscher, Guy Vergères. Identification of Urinary Food Intake Biomarkers for Milk, Cheese, and Soy-Based Drink by Untargeted GC-MS and NMR in Healthy Humans. Journal of proteome research. 2017 09; 16(9):3321-3335. doi: 10.1021/acs.jproteome.7b00319. [PMID: 28753012]
  • Vanessa Df de Mello, Maria A Lankinen, Jaana Lindström, Riitta Puupponen-Pimiä, David E Laaksonen, Jussi Pihlajamäki, Marko Lehtonen, Matti Uusitupa, Jaakko Tuomilehto, Marjukka Kolehmainen, Riitta Törrönen, Kati Hanhineva. Fasting serum hippuric acid is elevated after bilberry (Vaccinium myrtillus) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes. Molecular nutrition & food research. 2017 09; 61(9):. doi: 10.1002/mnfr.201700019. [PMID: 28556578]
  • Nishikant Wase, Boqiang Tu, James W Allen, Paul N Black, Concetta C DiRusso. Identification and Metabolite Profiling of Chemical Activators of Lipid Accumulation in Green Algae. Plant physiology. 2017 Aug; 174(4):2146-2165. doi: 10.1104/pp.17.00433. [PMID: 28652262]
  • Ivan N Perez-Maldonado, Angeles C Ochoa-Martinez, Sandra T Orta-Garcia, Tania Ruiz-Vera, Jose A Varela-Silva. Concentrations of Environmental Chemicals in Urine and Blood Samples of Children from San Luis Potosí, Mexico. Bulletin of environmental contamination and toxicology. 2017 Aug; 99(2):258-263. doi: 10.1007/s00128-017-2130-6. [PMID: 28646397]
  • Olivier Deltombe, Henriette de Loor, Griet Glorieux, Annemieke Dhondt, Wim Van Biesen, Björn Meijers, Sunny Eloot. Exploring binding characteristics and the related competition of different protein-bound uremic toxins. Biochimie. 2017 Aug; 139(?):20-26. doi: 10.1016/j.biochi.2017.05.010. [PMID: 28528271]
  • Pablo Hernández-Alonso, Daniel Cañueto, Simona Giardina, Jordi Salas-Salvadó, Nicolau Cañellas, Xavier Correig, Mònica Bulló. Effect of pistachio consumption on the modulation of urinary gut microbiota-related metabolites in prediabetic subjects. The Journal of nutritional biochemistry. 2017 07; 45(?):48-53. doi: 10.1016/j.jnutbio.2017.04.002. [PMID: 28432876]
  • T Pallister, M A Jackson, T C Martin, C A Glastonbury, A Jennings, M Beaumont, R P Mohney, K S Small, A MacGregor, C J Steves, A Cassidy, T D Spector, C Menni, A M Valdes. Untangling the relationship between diet and visceral fat mass through blood metabolomics and gut microbiome profiling. International journal of obesity (2005). 2017 07; 41(7):1106-1113. doi: 10.1038/ijo.2017.70. [PMID: 28293020]
  • Fandi Kong, Xiaoyan Pang, Kan Zhong, Zitao Guo, Xiuli Li, Dafang Zhong, Xiaoyan Chen. Increased Plasma Exposures of Conjugated Metabolites of Morinidazole in Renal Failure Patients: A Critical Role of Uremic Toxins. Drug metabolism and disposition: the biological fate of chemicals. 2017 06; 45(6):593-603. doi: 10.1124/dmd.116.074492. [PMID: 28314825]
  • Antonio Tursi, Paola Mastromarino, Daniela Capobianco, Walter Elisei, Alfredo Miccheli, Giulia Pratico', Marcello Picchio, Giovanni Brandimarte. Urinary metabolic profiling and symptomatic uncomplicated diverticular disease of the colon. Clinics and research in hepatology and gastroenterology. 2017 Jun; 41(3):344-346. doi: 10.1016/j.clinre.2017.01.006. [PMID: 28286055]
  • Mark J W McPhail, Sara Montagnese, Manuela Villanova, Hamza El Hadi, Piero Amodio, Mary M E Crossey, Roger Williams, I Jane Cox, Simon D Taylor-Robinson. Urinary metabolic profiling by 1H NMR spectroscopy in patients with cirrhosis may discriminate overt but not covert hepatic encephalopathy. Metabolic brain disease. 2017 04; 32(2):331-341. doi: 10.1007/s11011-016-9904-0. [PMID: 27638475]
  • Carolina Nasser Boscari, Giovanna Rodrigues Mazzuia, Célio Wisniewski, Keyller Bastos Borges, Eduardo Costa Figueiredo. Molecularly imprinted probe for solid-phase extraction of hippuric and 4-methylhippuric acids directly from human urine samples followed by MEKC analysis. Electrophoresis. 2017 04; 38(7):1083-1090. doi: 10.1002/elps.201600382. [PMID: 27982439]
  • Matthew B Rivara, Leila R Zelnick, Andrew N Hoofnagle, Rick Newitt, Russell P Tracy, Mario Kratz, David S Weigle, Bryan R Kestenbaum. Diurnal and Long-term Variation in Plasma Concentrations and Renal Clearances of Circulating Markers of Kidney Proximal Tubular Secretion. Clinical chemistry. 2017 04; 63(4):915-923. doi: 10.1373/clinchem.2016.260117. [PMID: 28188231]
  • Luciano Vitali, Samantha Gonçalves, Victor Rodrigues, Valfredo T Fávere, Gustavo A Micke. Development of a fast method for simultaneous determination of hippuric acid, mandelic acid, and creatinine in urine by capillary zone electrophoresis using polymer multilayer-coated capillary. Analytical and bioanalytical chemistry. 2017 Mar; 409(7):1943-1950. doi: 10.1007/s00216-016-0142-4. [PMID: 27988799]
  • Hidenori Kamiguchi, Mika Murabayashi, Ikuo Mori, Akira Horinouchi, Kazutaka Higaki. Biomarker discovery for drug-induced phospholipidosis: phenylacetylglycine to hippuric acid ratio in urine and plasma as potential markers. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2017 Mar; 22(2):178-188. doi: 10.1080/1354750x.2016.1252958. [PMID: 27775443]
  • Katharina J Penczynski, Danika Krupp, Anna Bring, Katja Bolzenius, Thomas Remer, Anette E Buyken. Relative validation of 24-h urinary hippuric acid excretion as a biomarker for dietary flavonoid intake from fruit and vegetables in healthy adolescents. European journal of nutrition. 2017 Mar; 56(2):757-766. doi: 10.1007/s00394-015-1121-9. [PMID: 26658765]
  • Cristina Román-Hidalgo, María Jesús Martín-Valero, Rut Fernández-Torres, Manuel Callejón-Mochón, Miguel Ángel Bello-López. New nanostructured support for carrier-mediated electromembrane extraction of high polar compounds. Talanta. 2017 Jan; 162(?):32-37. doi: 10.1016/j.talanta.2016.10.022. [PMID: 27837836]
  • Guangyong Zhao. Modulation of Protein Metabolism to Mitigate Nitrous Oxide (N2O) Emission from Excreta of Livestock. Current protein & peptide science. 2017; 18(6):525-531. doi: 10.2174/1389203717666160627080423. [PMID: 27356937]
  • Kelly Mercier, Susan McRitchie, Wimal Pathmasiri, Andrew Novokhatny, Rajesh Koralkar, David Askenazi, Patrick D Brophy, Susan Sumner. Preterm neonatal urinary renal developmental and acute kidney injury metabolomic profiling: an exploratory study. Pediatric nephrology (Berlin, Germany). 2017 01; 32(1):151-161. doi: 10.1007/s00467-016-3439-9. [PMID: 27435284]
  • Liqiang Gu, Huiyan Shi, Ruowen Zhang, Zhe Wei, Kai-Shun Bi, Xiao-Hui Chen. Simultaneous Determination of Five Specific and Sensitive Nephrotoxicity Biomarkers in Serum and Urine Samples of Four Drug-Induced Kidney Injury Models. Journal of chromatographic science. 2017 01; 55(1):60-68. doi: 10.1093/chromsci/bmw150. [PMID: 27993865]
  • Kiyoshi Fukuhara, Akiko Ohno, Ruri Kikura-Hanajiri. A Metabolic Study on the Biochemical Effects of Chiral Illegal Drugs in Rats Using 1H-NMR Spectroscopy. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2017; 137(9):1147-1154. doi: 10.1248/yakushi.17-00046. [PMID: 28867701]
  • Sunny Eloot, Wim Van Biesen, Sanne Roels, Willem Delrue, Eva Schepers, Annemieke Dhondt, Raymond Vanholder, Griet Glorieux. Spontaneous variability of pre-dialysis concentrations of uremic toxins over time in stable hemodialysis patients. PloS one. 2017; 12(10):e0186010. doi: 10.1371/journal.pone.0186010. [PMID: 29016645]
  • Julian K Aschoff, Ken M Riedl, Jessica L Cooperstone, Josef Högel, Anja Bosy-Westphal, Steven J Schwartz, Reinhold Carle, Ralf M Schweiggert. Urinary excretion of Citrus flavanones and their major catabolites after consumption of fresh oranges and pasteurized orange juice: A randomized cross-over study. Molecular nutrition & food research. 2016 12; 60(12):2602-2610. doi: 10.1002/mnfr.201600315. [PMID: 27488098]
  • Hidenori Kamiguchi, Masashi Yamaguchi, Mika Murabayashi, Ikuo Mori, Akira Horinouchi. Method development and validation for simultaneous quantitation of endogenous hippuric acid and phenylacetylglycine in rat urine using liquid chromatography coupled with electrospray ionization tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Nov; 1035(?):76-83. doi: 10.1016/j.jchromb.2016.09.036. [PMID: 27697729]
  • Gina Borges, Justin J J van der Hooft, Alan Crozier. A comprehensive evaluation of the [2-14C](-)-epicatechin metabolome in rats. Free radical biology & medicine. 2016 10; 99(?):128-138. doi: 10.1016/j.freeradbiomed.2016.08.001. [PMID: 27495388]
  • Panteleimon G Takis, Mariam-Eleni Oraiopoulou, Constantinos Konidaris, Anastassios N Troganis. (1)H-NMR based metabolomics study for the detection of the human urine metabolic profile effects of Origanum dictamnus tea ingestion. Food & function. 2016 Sep; 7(9):4104-15. doi: 10.1039/c6fo00560h. [PMID: 27602787]
  • Haiyan Liu, Fariba Tayyari, Arthur S Edison, Zhihua Su, Liwei Gu. NMR-based metabolomics reveals urinary metabolome modifications in female Sprague-Dawley rats by cranberry procyanidins. The Journal of nutritional biochemistry. 2016 08; 34(?):136-45. doi: 10.1016/j.jnutbio.2016.05.007. [PMID: 27309592]
  • Claudia Vetrani, Angela A Rivellese, Giovanni Annuzzi, Martin Adiels, Jan Borén, Ismo Mattila, Matej Orešič, Anna-Marja Aura. Metabolic transformations of dietary polyphenols: comparison between in vitro colonic and hepatic models and in vivo urinary metabolites. The Journal of nutritional biochemistry. 2016 07; 33(?):111-8. doi: 10.1016/j.jnutbio.2016.03.007. [PMID: 27155917]
  • J J Qiu, X L Ruan, B H Wu, W F Rong, R B Meng. [Determination of hippuric acid and methylhippuric acid in urine by high performance liquid chromatography after extracted with acetonitrile]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. 2016 Apr; 34(4):304-7. doi: 10.3760/cma.j.issn.1001-9391.2016.04.020. [PMID: 27514272]
  • Raween Kalicharan, Mohsin El Amrani, Peter Schot, Herman Vromans. Pharmacokinetics in Elderly Women of Benzyl Alcohol From an Oil Depot. Journal of pharmaceutical sciences. 2016 Apr; 105(4):1519-25. doi: 10.1016/j.xphs.2016.01.022. [PMID: 27019966]
  • Carla Nortje, Rencia van der Sluis, Alberdina Aike van Dijk, Elardus Erasmus. The Use of p-Aminobenzoic Acid as a Probe Substance for the Targeted Profiling of Glycine Conjugation. Journal of biochemical and molecular toxicology. 2016 Mar; 30(3):136-47. doi: 10.1002/jbt.21772. [PMID: 26484797]
  • Ramandeep Garg, Lorraine Brennan, Ruth K Price, Julie M W Wallace, J J Strain, Mike J Gibney, Peter R Shewry, Jane L Ward, Lalit Garg, Robert W Welch. Using NMR-Based Metabolomics to Evaluate Postprandial Urinary Responses Following Consumption of Minimally Processed Wheat Bran or Wheat Aleurone by Men and Women. Nutrients. 2016 Feb; 8(2):96. doi: 10.3390/nu8020096. [PMID: 26901221]
  • Danika Krupp, Thomas Remer, Katharina J Penczynski, Katja Bolzenius, Stefan A Wudy, Anette E Buyken. Relevance of fruits, vegetables and flavonoids from fruits and vegetables during early life, mid-childhood and adolescence for levels of insulin-like growth factor (IGF-1) and its binding proteins IGFBP-2 and IGFBP-3 in young adulthood. The British journal of nutrition. 2016 Feb; 115(3):527-37. doi: 10.1017/s0007114515004742. [PMID: 26628272]
  • Danika Krupp, Lijie Shi, Sarah Egert, Stefan A Wudy, Thomas Remer. Prospective relevance of fruit and vegetable consumption and salt intake during adolescence for blood pressure in young adulthood. European journal of nutrition. 2015 Dec; 54(8):1269-79. doi: 10.1007/s00394-014-0804-y. [PMID: 25410750]
  • Lee Cheng Phua, Clive H Wilder-Smith, Yee Min Tan, Theebarina Gopalakrishnan, Reuben K Wong, Xinhua Li, Mary E Kan, Jia Lu, Ali Keshavarzian, Eric Chun Yong Chan. Gastrointestinal Symptoms and Altered Intestinal Permeability Induced by Combat Training Are Associated with Distinct Metabotypic Changes. Journal of proteome research. 2015 Nov; 14(11):4734-42. doi: 10.1021/acs.jproteome.5b00603. [PMID: 26506213]
  • Ji-Na Hao, Bing Yan. Recyclable lanthanide-functionalized MOF hybrids to determine hippuric acid in urine as a biological index of toluene exposure. Chemical communications (Cambridge, England). 2015 Oct; 51(77):14509-12. doi: 10.1039/c5cc05219j. [PMID: 26280941]
  • Olivier Deltombe, Wim Van Biesen, Griet Glorieux, Ziad Massy, Annemieke Dhondt, Sunny Eloot. Exploring Protein Binding of Uremic Toxins in Patients with Different Stages of Chronic Kidney Disease and during Hemodialysis. Toxins. 2015 Sep; 7(10):3933-46. doi: 10.3390/toxins7103933. [PMID: 26426048]
  • Daniela Remane, Soeren Grunwald, Henrike Hoeke, Andrea Mueller, Stefan Roeder, Martin von Bergen, Dirk K Wissenbach. Validation of a multi-analyte HPLC-DAD method for determination of uric acid, creatinine, homovanillic acid, niacinamide, hippuric acid, indole-3-acetic acid and 2-methylhippuric acid in human urine. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2015 Aug; 998-999(?):40-4. doi: 10.1016/j.jchromb.2015.06.021. [PMID: 26151191]
  • Abishek Bommannan Santhakumar, Roger Stanley, Indu Singh. The ex vivo antiplatelet activation potential of fruit phenolic metabolite hippuric acid. Food & function. 2015 Aug; 6(8):2679-83. doi: 10.1039/c5fo00715a. [PMID: 26137920]
  • Naiara Orrego-Lagarón, Miriam Martínez-Huélamo, Anna Vallverdú-Queralt, Rosa M Lamuela-Raventos, Elvira Escribano-Ferrer. High gastrointestinal permeability and local metabolism of naringenin: influence of antibiotic treatment on absorption and metabolism. The British journal of nutrition. 2015 Jul; 114(2):169-80. doi: 10.1017/s0007114515001671. [PMID: 26083965]
  • Renata P Assis, Juliana F A Castro, Vânia O Gutierres, Carlos A Arcaro, Renata S Brotto, Olga M M F Oliveira, Amanda M Baviera, Iguatemy L Brunetti. Effects of uremic solutes on reactive oxygen species in vitro model systems as a possibility of support the renal function management. BMC nephrology. 2015 Apr; 16(?):50. doi: 10.1186/s12882-015-0029-1. [PMID: 25886160]