3,7,4-Trihydroxyflavone (BioDeep_00000398537)

Main id: BioDeep_00000395491

Secondary id: BioDeep_00000003595

PANOMIX_OTCML-2023


代谢物信息卡片


3,7,4-Trihydroxyflavone

化学式: C15H10O5 (270.0528)
中文名称: 5-脱氧莰非醇
谱图信息: 最多检出来源 Viridiplantae(plant) 12.52%

分子结构信息

SMILES: C1=CC(=CC=C1C2=C(C(=O)C3=C(O2)C=C(C=C3)O)O)O
InChI: InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)15-14(19)13(18)11-6-5-10(17)7-12(11)20-15/h1-7,16-17,19H

描述信息

relative retention time with respect to 9-anthracene Carboxylic Acid is 0.962
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.958
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.954
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.955
3,7,4'-Trihydroxyflavone, isolated from Rhus javanica var. roxburghiana, is a flavonoid with DNA strand-scission activity[1].
3,7,4'-Trihydroxyflavone, isolated from Rhus javanica var. roxburghiana, is a flavonoid with DNA strand-scission activity[1].

同义名列表

4 个代谢物同义名

3,7,4-Trihydroxyflavone; 5-Deoxykampferol; 3,7,4'-Trihydroxyflavone; Resokaempherol



数据库引用编号

23 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

21 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 CA1, CAT, JAK2, MAPK14, MAPK8, PTGS2, RPS6KA3, STAT3, VEGFA
Peripheral membrane protein 2 JAK2, PTGS2
Endoplasmic reticulum membrane 2 PTGS2, UGT1A1
Nucleus 7 JAK2, MAPK14, MAPK8, PCNA, RPS6KA3, STAT3, VEGFA
cytosol 7 CA1, CAT, JAK2, MAPK14, MAPK8, RPS6KA3, STAT3
nuclear body 1 PCNA
centrosome 1 PCNA
nucleoplasm 6 JAK2, MAPK14, MAPK8, PCNA, RPS6KA3, STAT3
RNA polymerase II transcription regulator complex 1 STAT3
Multi-pass membrane protein 1 SLC45A2
Synapse 2 MAPK8, RPS6KA3
cell surface 1 VEGFA
glutamatergic synapse 2 JAK2, MAPK14
Golgi apparatus 1 VEGFA
postsynapse 1 JAK2
plasma membrane 3 JAK2, STAT3, UGT1A1
Membrane 5 CAT, JAK2, SLC45A2, UGT1A1, VEGFA
axon 1 MAPK8
caveola 2 JAK2, PTGS2
extracellular exosome 3 CA1, CAT, PCNA
endoplasmic reticulum 3 PTGS2, UGT1A1, VEGFA
extracellular space 1 VEGFA
perinuclear region of cytoplasm 1 UGT1A1
adherens junction 1 VEGFA
mitochondrion 2 CAT, MAPK14
protein-containing complex 2 CAT, PTGS2
intracellular membrane-bounded organelle 1 CAT
Microsome membrane 1 PTGS2
Secreted 1 VEGFA
extracellular region 3 CAT, MAPK14, VEGFA
cytoplasmic side of plasma membrane 1 JAK2
Single-pass membrane protein 1 UGT1A1
mitochondrial matrix 1 CAT
transcription regulator complex 1 STAT3
Secreted, extracellular space, extracellular matrix 1 VEGFA
nucleolus 1 RPS6KA3
Melanosome membrane 1 SLC45A2
Cytoplasm, perinuclear region 1 UGT1A1
Membrane raft 1 JAK2
focal adhesion 2 CAT, JAK2
extracellular matrix 1 VEGFA
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
secretory granule 1 VEGFA
nuclear speck 1 MAPK14
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
chromatin 2 PCNA, STAT3
cytoskeleton 1 JAK2
spindle pole 1 MAPK14
nuclear replication fork 1 PCNA
chromosome, telomeric region 1 PCNA
Endomembrane system 1 JAK2
endosome lumen 1 JAK2
euchromatin 1 JAK2
replication fork 1 PCNA
ficolin-1-rich granule lumen 2 CAT, MAPK14
secretory granule lumen 2 CAT, MAPK14
endoplasmic reticulum lumen 1 PTGS2
male germ cell nucleus 1 PCNA
platelet alpha granule lumen 1 VEGFA
nuclear lamina 1 PCNA
extrinsic component of cytoplasmic side of plasma membrane 1 JAK2
basal dendrite 1 MAPK8
extrinsic component of plasma membrane 1 JAK2
granulocyte macrophage colony-stimulating factor receptor complex 1 JAK2
interleukin-12 receptor complex 1 JAK2
interleukin-23 receptor complex 1 JAK2
cyclin-dependent protein kinase holoenzyme complex 1 PCNA
ribosome 1 RPS6KA3
catalase complex 1 CAT
endoplasmic reticulum chaperone complex 1 UGT1A1
PCNA complex 1 PCNA
PCNA-p21 complex 1 PCNA
replisome 1 PCNA
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
cytochrome complex 1 UGT1A1


文献列表

  • Myeong Hyeon Park, In Sook Kim, Sun-A Kim, Chun-Soo Na, Cheol Yi Hong, Mi-Sook Dong, Hye Hyun Yoo. Inhibitory effect of Rhus verniciflua Stokes extract on human aromatase activity; butin is its major bioactive component. Bioorganic & medicinal chemistry letters. 2014 Apr; 24(7):1730-3. doi: 10.1016/j.bmcl.2014.02.039. [PMID: 24630560]
  • S Saponara, E Carosati, P Mugnai, G Sgaragli, F Fusi. The flavonoid scaffold as a template for the design of modulators of the vascular Ca(v) 1.2 channels. British journal of pharmacology. 2011 Nov; 164(6):1684-97. doi: 10.1111/j.1476-5381.2011.01476.x. [PMID: 21557738]
  • Phongsak Innok, Thitima Rukachaisirikul, Souwalak Phongpaichit, Apichart Suksamrarn. Fuscacarpans A-C, new pterocarpans from the stems of Erythrina fusca. Fitoterapia. 2010 Sep; 81(6):518-23. doi: 10.1016/j.fitote.2010.01.009. [PMID: 20079815]
  • Chun-Nan Lin, Hui-Ling Chen, Ming-Hong Yen. Flavonoids with DNA strand-scission activity from Rhus javanica var. roxburghiana. Fitoterapia. 2008 Jan; 79(1):32-6. doi: 10.1016/j.fitote.2007.07.008. [PMID: 17855017]
  • M Abou-Shoer, G E Ma, X H Li, N M Koonchanok, R L Geahlen, C J Chang. Flavonoids from Koelreuteria henryi and other sources as protein-tyrosine kinase inhibitors. Journal of natural products. 1993 Jun; 56(6):967-9. doi: 10.1021/np50096a027. [PMID: 8350096]