Saikosaponin A (BioDeep_00000398476)

Main id: BioDeep_00000000152

Secondary id: BioDeep_00000017308

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


Saikosaponin A

化学式: C42H68O13 (780.466)
中文名称: 柴胡皂苷A, 柴胡皂苷 A
谱图信息: 最多检出来源 Viridiplantae(plant) 23.68%

分子结构信息

SMILES: C(C([H])54)(C1)(C)C([H])(CCC4(C(C7)(C(O8)(C(C(C8)6C(O)7)(CC(CC6)(C)C)[H])C=C5)C)C)C(C(OC(O3)([H])C(C(C(C3C)O)OC(C(O)2)(OC(C(C2O)O)CO)[H])O)C1)(C)CO
InChI: InChI=1S/C42H68O13/c1-21-28(46)33(55-34-31(49)30(48)29(47)22(18-43)53-34)32(50)35(52-21)54-27-10-11-37(4)23(38(27,5)19-44)8-12-39(6)24(37)9-13-42-25-16-36(2,3)14-15-41(25,20-51-42)26(45)17-40(39,42)7/h9,13,21-35,43-50H,8,10-12,14-20H2,1-7H3

描述信息

Annotation level-1
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
D000893 - Anti-Inflammatory Agents
D000970 - Antineoplastic Agents
D018501 - Antirheumatic Agents
Saikosaponin A is an active component of Bupleurum chinensis, up-regulates LXRα expression, with potent anti-inflammatory activity[1].
Saikosaponin A is an active component of Bupleurum chinensis, up-regulates LXRα expression, with potent anti-inflammatory activity[1].
Saikosaponin A is an active component of Bupleurum chinensis, up-regulates LXRα expression, with potent anti-inflammatory activity[1].

同义名列表

2 个代谢物同义名

Saikosaponin A; Saikosaponin A



数据库引用编号

50 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

71 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 ABCB1, BCL2, BDNF, CASP3, MAPK14, MTOR, NLRP3, PTGS2, RB1, STAT3, TLR4
Peripheral membrane protein 3 GORASP1, MTOR, PTGS2
Endosome membrane 1 TLR4
Endoplasmic reticulum membrane 4 BCL2, HMOX1, MTOR, PTGS2
Nucleus 10 BCL2, CASP3, FOS, GABPA, HMOX1, MAPK14, MTOR, NLRP3, RB1, STAT3
cytosol 10 BCL2, CASP3, FOS, HMOX1, LIPE, MAPK14, MTOR, NLRP3, RB1, STAT3
dendrite 2 BDNF, MTOR
phagocytic vesicle 1 MTOR
nucleoplasm 8 CASP3, FOS, GABPA, HMOX1, MAPK14, MTOR, RB1, STAT3
RNA polymerase II transcription regulator complex 2 FOS, STAT3
Cell membrane 4 ABCB1, LIPE, TLR4, TNF
Cytoplasmic side 3 GORASP1, HMOX1, MTOR
Multi-pass membrane protein 1 ABCB1
Golgi apparatus membrane 3 GORASP1, MTOR, NLRP3
cell surface 3 ABCB1, TLR4, TNF
glutamatergic synapse 2 CASP3, MAPK14
Golgi apparatus 1 GORASP1
Golgi membrane 3 GORASP1, MTOR, NLRP3
lysosomal membrane 1 MTOR
neuronal cell body 2 CASP3, TNF
synaptic vesicle 1 BDNF
Cytoplasm, cytosol 2 LIPE, NLRP3
Lysosome 1 MTOR
plasma membrane 4 ABCB1, STAT3, TLR4, TNF
Membrane 8 ABCB1, BCL2, BDNF, HMOX1, LIPE, MTOR, NLRP3, TLR4
apical plasma membrane 1 ABCB1
axon 1 BDNF
caveola 2 LIPE, PTGS2
extracellular exosome 1 ABCB1
Lysosome membrane 1 MTOR
endoplasmic reticulum 5 BCL2, FOS, HMOX1, NLRP3, PTGS2
extracellular space 6 BDNF, HMOX1, IL10, IL2, IL6, TNF
perinuclear region of cytoplasm 3 BDNF, HMOX1, TLR4
mitochondrion 3 BCL2, MAPK14, NLRP3
protein-containing complex 2 BCL2, PTGS2
Microsome membrane 2 MTOR, PTGS2
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 TLR4
Secreted 5 BDNF, IL10, IL2, IL6, NLRP3
extracellular region 7 BDNF, IL10, IL2, IL6, MAPK14, NLRP3, TNF
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 3 BCL2, HMOX1, MTOR
transcription regulator complex 1 STAT3
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 TLR4, TNF
Early endosome 1 TLR4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 1 ABCB1
Membrane raft 1 TNF
pore complex 1 BCL2
spindle 1 RB1
cis-Golgi network 1 GORASP1
Nucleus, PML body 1 MTOR
PML body 2 MTOR, RB1
nuclear speck 1 MAPK14
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 1 NLRP3
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 1 TLR4
neuron projection 1 PTGS2
chromatin 4 FOS, GABPA, RB1, STAT3
phagocytic cup 2 TLR4, TNF
spindle pole 1 MAPK14
nuclear envelope 1 MTOR
Endomembrane system 2 MTOR, NLRP3
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
microtubule organizing center 1 NLRP3
myelin sheath 1 BCL2
lipopolysaccharide receptor complex 1 TLR4
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 1 MAPK14
endoplasmic reticulum lumen 3 BDNF, IL6, PTGS2
nuclear matrix 1 FOS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GORASP1
SWI/SNF complex 1 RB1
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
Single-pass type IV membrane protein 1 HMOX1
protein-DNA complex 1 FOS
external side of apical plasma membrane 1 ABCB1
death-inducing signaling complex 1 CASP3
Cytoplasmic vesicle, phagosome 1 MTOR
transcription factor AP-1 complex 1 FOS
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
interleukin-6 receptor complex 1 IL6
chromatin lock complex 1 RB1
Rb-E2F complex 1 RB1
BAD-BCL-2 complex 1 BCL2
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Rui Zhang, Xiangchuan Li, Jixu Qu, Doudou Zhang, Linxu Cao, Xuemei Qin, Zhenyu Li. Intercropping with maize and sorghum-induced saikosaponin accumulation in Bupleurum chinense DC. by liquid chromatography-mass spectrometry-based metabolomics. Journal of mass spectrometry : JMS. 2024 Jun; 59(6):e5035. doi: 10.1002/jms.5035. [PMID: 38726730]
  • Mingxia Xie, Hongping Long, Sainan Tian, Zhengqing Zhu, Pan Meng, Ke Du, Yajing Wang, Dongwei Guo, Hanqing Wang, Qinghua Peng. Saikosaponin F ameliorates depression-associated dry eye disease by inhibiting TRIM8-induced TAK1 ubiquitination. International immunopharmacology. 2024 Mar; 130(?):111749. doi: 10.1016/j.intimp.2024.111749. [PMID: 38430804]
  • Y Xiong, X Liang, X Liang, W Li, Y Qian, W Xie. [Saikosaponin a alleviates pentylenetetrazol-induced acute epileptic seizures in mouse models of depression by suppressing microglia activation-mediated inflammation]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2024 Mar; 44(3):515-522. doi: 10.12122/j.issn.1673-4254.2024.03.13. [PMID: 38597443]
  • Yupeng Cheng, Yuanzhen Liu, Xinhong Li, Guangjie Liu, Zhongmeng Li, Bo Liu, Ning Gao. Transcriptome analysis of the mechanism of endophytic fungus CHS3 promoting saikosaponin d synthesis in Bupleurum scorzonerifolium Willd. suspension cells. Fitoterapia. 2024 Mar; 173(?):105778. doi: 10.1016/j.fitote.2023.105778. [PMID: 38128620]
  • Shen Chen, Ke Wang, Hongzhan Wang, Yang Gao, Kexin Nie, Xinyue Jiang, Hao Su, Yueheng Tang, Fuer Lu, Hui Dong, Zhi Wang. The therapeutic effects of saikosaponins on depression through the modulation of neuroplasticity: From molecular mechanisms to potential clinical applications. Pharmacological research. 2024 Mar; 201(?):107090. doi: 10.1016/j.phrs.2024.107090. [PMID: 38309381]
  • Tiantian Gao, Tao Wang, Lili Wu, Yue Tong, Jinlong Tian, Keke Zhao, Hanqing Wang. Saikosaponin-d alleviates depression by promoting NLRP3 ubiquitination and inhibiting inflammasome activation. International immunopharmacology. 2024 Jan; 127(?):111324. doi: 10.1016/j.intimp.2023.111324. [PMID: 38070467]
  • Xuan-Jing Shen, Jian-Qing Zhang, Ya-Ling An, Lin Yang, Xiao-Lan Li, Yun-Shu Hu, Fei Sha, Chang-Liang Yao, Qi-Rui Bi, Hua Qu, De-An Guo. MATLAB language assisted data acquisition and processing in liquid chromatography Orbitrap mass spectrometry: Application to the identification and differentiation of Radix Bupleuri from its adulterants. Journal of chromatography. A. 2024 Jan; 1714(?):464544. doi: 10.1016/j.chroma.2023.464544. [PMID: 38142618]
  • Min-Seong Lee, Ji-Won Noh, Byung-Cheol Lee. Effects of Saikosaponin-A on Insulin Resistance in Obesity: Computational and Animal Experimental Study. Chemical & pharmaceutical bulletin. 2024; 72(4):365-373. doi: 10.1248/cpb.c23-00782. [PMID: 38569867]
  • Jie Tang, Lixiang Wang, Mengge Shi, Shuaixia Feng, Tong Zhang, Han Han. Study on the mechanism of Shuganzhi Tablet against nonalcoholic fatty liver disease and lipid regulation effects of its main substances in vitro. Journal of ethnopharmacology. 2023 Nov; 316(?):116780. doi: 10.1016/j.jep.2023.116780. [PMID: 37311504]
  • Xinmei Wang, Shanshan Li, Jiayu Yu, Wenlin Wang, Zhuoqi Du, Shuchun Gao, Yin Ma, Ruixin Tang, Ting Liu, Shiping Ma, Qiang Fu, Xueyang Deng. Saikosaponin B2 ameliorates depression-induced microglia activation by inhibiting ferroptosis-mediated neuroinflammation and ER stress. Journal of ethnopharmacology. 2023 Nov; 316(?):116729. doi: 10.1016/j.jep.2023.116729. [PMID: 37277081]
  • Yue Tong, Ge Zhao, Ruonan Shuang, Hanqing Wang, Nan Zeng. Saikosaponin a activates tet1/dll3/notch1 signalling and promotes hippocampal neurogenesis to improve depression-like behavior in mice. Journal of ethnopharmacology. 2023 Oct; 319(Pt 3):117289. doi: 10.1016/j.jep.2023.117289. [PMID: 37844745]
  • Jia Feng, Hui Ma, Yanrui Yue, Lijun Wang, Keyang Hao, Yanan Zhang, Jinghe Li, Yujun Xiang, Yuna Min. Saikosaponin a ameliorates diet-induced fatty liver via regulating intestinal microbiota and bile acid profile in laying hens. Poultry science. 2023 Sep; 102(12):103155. doi: 10.1016/j.psj.2023.103155. [PMID: 37871490]
  • Xinsheng Xu, Lihua Cui, Lanqiu Zhang, Lei Yang, Yuzhen Zhuo, Caixia Li. Saikosaponin d modulates the polarization of tumor-associated macrophages by deactivating the PI3K/AKT/mTOR pathway in murine models of pancreatic cancer. International immunopharmacology. 2023 Sep; 122(?):110579. doi: 10.1016/j.intimp.2023.110579. [PMID: 37433245]
  • Chao Wang, Ruijuan Zhang, Xu Chen, Mengyun Yuan, Jian Wu, Qingmin Sun, Chunrun Miao, Yali Jing. The potential effect and mechanism of Saikosaponin A against gastric cancer. BMC complementary medicine and therapies. 2023 Aug; 23(1):295. doi: 10.1186/s12906-023-04108-3. [PMID: 37608281]
  • Shijie Bi, Yanan Liu, Tianyi Lv, Yue Ren, Kaiyang Liu, Chaoqun Liu, Yanling Zhang. Preliminary exploration of method for screening efficacy markers compatibility in TCM prescriptions based on Q-markers: Anti-inflammatory activity of Dachaihu decoction as an example. Journal of ethnopharmacology. 2023 Aug; 312(?):116539. doi: 10.1016/j.jep.2023.116539. [PMID: 37088240]
  • Hui He, Jiaqi Guo, Yunxiang Hu, Han Zhang, Xinyang Li, Jian Zhang, Shi Jin. Saikosaponin D reverses epinephrine- and norepinephrine-induced gemcitabine resistance in intrahepatic cholangiocarcinoma by downregulating ADRB2/glycolysis signaling. Acta biochimica et biophysica Sinica. 2023 Jul; ?(?):. doi: 10.3724/abbs.2023040. [PMID: 37489008]
  • Zhenhuan Wang, Lu Tian, Yusheng Xiao, Mengya Zhao, Yanyan Chang, Yujiang Zhou, Shuying Liu, Huanxi Zhao, Yang Xiu. Quantitative and Differential Analysis between Bupleurum chinense DC. and Bupleurum scorzonerifolium Willd. Using HPLC-MS and GC-MS Coupled with Multivariate Statistical Analysis. Molecules (Basel, Switzerland). 2023 Jul; 28(15):. doi: 10.3390/molecules28155630. [PMID: 37570602]
  • Tong-Tong Tang, Li Jiang, Qian Zhong, Zhi-Jing Ni, Kiran Thakur, Mohammad Rizwan Khan, Zhao-Jun Wei. Saikosaponin D exerts cytotoxicity on human endometrial cancer ishikawa cells by inducing apoptosis and inhibiting metastasis through MAPK pathways. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023 Jul; 177(?):113815. doi: 10.1016/j.fct.2023.113815. [PMID: 37209937]
  • Man You, Junmin Fu, Xingzhi Lv, Lan Wang, Hongwei Wang, Ruifang Li. Saikosaponin b2 inhibits tumor angiogenesis in liver cancer via down‑regulation of VEGF/ERK/HIF‑1α signaling. Oncology reports. 2023 07; 50(1):. doi: 10.3892/or.2023.8573. [PMID: 37232376]
  • Tian Lan, Wen Wang, Xi-Xi Zeng, Yu-Hua Tong, Zhu-Jun Mao, Si-Wei Wang. Saikosaponin A triggers cell ferroptosis in hepatocellular carcinoma by inducing endoplasmic reticulum stress-stimulated ATF3 expression. Biochemical and biophysical research communications. 2023 Jun; 674(?):10-18. doi: 10.1016/j.bbrc.2023.06.086. [PMID: 37393639]
  • Yingchao Zhu, Yu Lai. Pharmacological properties and derivatives of saikosaponins-a review of recent studies. The Journal of pharmacy and pharmacology. 2023 Jun; ?(?):. doi: 10.1093/jpp/rgad052. [PMID: 37307427]
  • Rong Yang, Linhua Liu, Dansheng Jiang, Lei Liu, Huili Yang, Hongling Xu, Meirong Qin, Ping Wang, Jiangyong Gu, Yufeng Xing. Identification of Potential TMPRSS2 Inhibitors for COVID-19 Treatment in Chinese Medicine by Computational Approaches and Surface Plasmon Resonance Technology. Journal of chemical information and modeling. 2023 May; ?(?):. doi: 10.1021/acs.jcim.2c01643. [PMID: 37155923]
  • Zijun Bai, Tiantian Gao, Rui Zhang, Youyuan Lu, Jinlong Tian, Tao Wang, Keke Zhao, Hanqing Wang. Inhibition of IL-6 methylation by Saikosaponin C regulates neuroinflammation to alleviate depression. International immunopharmacology. 2023 May; 118(?):110043. doi: 10.1016/j.intimp.2023.110043. [PMID: 36965369]
  • Yiqing Peng, Alam Nafee-Ul, Mingzhi Liu, Qiuling He, Zongsuo Liang. Assessment of Genetic Diversity in Bupleurum spp. Basing Agronomic Traits, Medicinal Components and ISSR Markers. Genes. 2023 04; 14(4):. doi: 10.3390/genes14040951. [PMID: 37107709]
  • Qi Zheng, Xiaojiaoyang Li, Nana Huang, Fanghong Li, Junde Ge, Daijie Wang, Rong Sun, Runping Liu. Saikosaponins ameliorate hyperlipidemia in rats by enhancing hepatic lipid and cholesterol metabolism. Journal of ethnopharmacology. 2023 Apr; 305(?):116110. doi: 10.1016/j.jep.2022.116110. [PMID: 36581162]
  • Ye-Feng Wang, Rui-Xia Ma, Bin Zou, Jia Li, Yao Yao, Juan Li. Endoplasmic reticulum stress regulates autophagic response that is involved in Saikosaponin a-induced liver cell damage. Toxicology in vitro : an international journal published in association with BIBRA. 2023 Apr; 88(?):105534. doi: 10.1016/j.tiv.2022.105534. [PMID: 36539104]
  • Wen-Xue Wang, Xiao-Wei DU, Bing-Yan Hou, Hong-Ru Zhu, Dan Yu. [Correlations between appearance traits and internal quality of Bupleurum scorzonerifolium roots based on theory of 'quality evaluation through morphological identification']. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Apr; 48(7):1815-1823. doi: 10.19540/j.cnki.cjcmm.20230115.102. [PMID: 37282956]
  • Minna Huang, Yan Yan, Zihao Deng, Lingli Zhou, Meiling She, Yajun Yang, Meng Zhang, Dongtao Wang. Saikosaponin A and D attenuate skeletal muscle atrophy in chronic kidney disease by reducing oxidative stress through activation of PI3K/AKT/Nrf2 pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Mar; 114(?):154766. doi: 10.1016/j.phymed.2023.154766. [PMID: 37002971]
  • Qingwei Xiang, Yu Liu, Li Chen. Saikosaponin d (SSD) alleviates diabetic peripheral neuropathy by regulating the AQP1/RhoA/ROCK signaling in streptozotocin-induced diabetic rats. Acta diabetologica. 2023 Mar; ?(?):. doi: 10.1007/s00592-023-02060-9. [PMID: 36920548]
  • Lin-Lin Chen, Liu-Yuan Xia, Jun-Ping Zhang, Yan Wang, Jian-Yu Chen, Cheng Guo, Wei-Heng Xu. Saikosaponin D alleviates cancer cachexia by directly inhibiting STAT3. Phytotherapy research : PTR. 2023 Mar; 37(3):809-819. doi: 10.1002/ptr.7676. [PMID: 36447385]
  • Jiling Feng, Zhichao Xi, Xue Jiang, Yang Li, Wan Najbah Nik Nabil, Mengfan Liu, Zejia Song, Xiaoqiong Chen, Hua Zhou, Qihan Dong, Hongxi Xu. Saikosaponin A enhances Docetaxel efficacy by selectively inducing death of dormant prostate cancer cells through excessive autophagy. Cancer letters. 2023 Feb; 554(?):216011. doi: 10.1016/j.canlet.2022.216011. [PMID: 36442771]
  • Donghui Peng, Yuchan Chen, Yanping Sun, Zhihong Zhang, Na Cui, Wensen Zhang, Ying Qi, Yuanning Zeng, Bin Hu, Bingyou Yang, Qiuhong Wang, Haixue Kuang. Saikosaponin A and Its Epimers Alleviate LPS-Induced Acute Lung Injury in Mice. Molecules (Basel, Switzerland). 2023 Jan; 28(3):. doi: 10.3390/molecules28030967. [PMID: 36770631]
  • Yuchan Li, Jun Zhao, Hua Chen, Yanping Mao, Yuping Yang, Liang Feng, Chuanxin Mo, Lin Huang, Dabin Hou, Ma Yu. Transcriptome Level Reveals the Triterpenoid Saponin Biosynthesis Pathway of Bupleurum falcatum L. Genes. 2022 11; 13(12):. doi: 10.3390/genes13122237. [PMID: 36553505]
  • Yupeng Cheng, Guangjie Liu, Zhongmeng Li, Yongqiang Zhou, Ning Gao. Screening saikosaponin d (SSd)-producing endophytic fungi from Bupleurum scorzonerifolium Willd. World journal of microbiology & biotechnology. 2022 Oct; 38(12):242. doi: 10.1007/s11274-022-03434-x. [PMID: 36280622]
  • Xiao Li, Ruihong Hou, Xuemei Qin, Yanfei Wu, Xingkang Wu, Junsheng Tian, Xiaoxia Gao, Guanhua Du, Yuzhi Zhou. Synergistic neuroprotective effect of saikosaponin A and albiflorin on corticosterone-induced apoptosis in PC12 cells via regulation of metabolic disorders and neuroinflammation. Molecular biology reports. 2022 Sep; 49(9):8801-8813. doi: 10.1007/s11033-022-07730-5. [PMID: 36002654]
  • Li-Li Li, Qi Huang, Jia-Jia Qi, Min Yao, Dai-Yin Peng. [Simultaneous determination and pharmacokinetic study of five compounds from total extract of Clinopodium chinense in abnormal uterine bleeding rat plasma by UPLC-MS/MS]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Sep; 47(18):5071-5078. doi: 10.19540/j.cnki.cjcmm.20220421.702. [PMID: 36164917]
  • Paola Maccioni, Giancarlo Colombo, Irene Lorrai, Jung Hwan Lee, Pisey Pel, Young-Won Chin, Hak Cheol Kwon. Suppressing effect of a saikosaponin-enriched extract of Bupleurum falcatum on alcohol and chocolate self-administration in rats. Natural product research. 2022 Sep; 36(17):4502-4505. doi: 10.1080/14786419.2021.1986816. [PMID: 34652253]
  • Linlin Yang, Lu Qiao, Xiuhong Su, Baoyu Ji, Chengming Dong. Drought Stress Stimulates the Terpenoid Backbone and Triterpenoid Biosynthesis Pathway to Promote the Synthesis of Saikosaponin in Bupleurum chinense DC. Roots. Molecules (Basel, Switzerland). 2022 Aug; 27(17):. doi: 10.3390/molecules27175470. [PMID: 36080237]
  • Yiqing Gu, Shuni Duan, Mingning Ding, Qi Zheng, Guifang Fan, Xiaojiaoyang Li, Yijie Li, Chuanyang Liu, Rong Sun, Runping Liu. Saikosaponin D attenuates metabolic associated fatty liver disease by coordinately tuning PPARα and INSIG/SREBP1c pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Aug; 103(?):154219. doi: 10.1016/j.phymed.2022.154219. [PMID: 35691075]
  • Wenjing Han, Jiao Xu, Hefang Wan, Lei Zhou, Bin Wu, Jianping Gao, Xinwei Guo, Chun Sui, Jianhe Wei. Overexpression of BcERF3 increases the biosynthesis of saikosaponins in Bupleurum chinense. FEBS open bio. 2022 07; 12(7):1344-1352. doi: 10.1002/2211-5463.13412. [PMID: 35429231]
  • Jia Luo, Juan Wang, Jun Yang, Wenjing Huang, Junqiu Liu, Wenfu Tan, Hong Xin. Saikosaponin B1 and Saikosaponin D inhibit tumor growth in medulloblastoma allograft mice via inhibiting the Hedgehog signaling pathway. Journal of natural medicines. 2022 Jun; 76(3):584-593. doi: 10.1007/s11418-022-01603-8. [PMID: 35171398]
  • Yu-Heng Zhong, Shan Jiang, Wei-Min Qu, Wen Zhang, Zhi-Li Huang, Chang-Rui Chen. Saikosaponin a promotes sleep by decreasing neuronal activities in the lateral hypothalamus. Journal of sleep research. 2022 04; 31(2):e13484. doi: 10.1111/jsr.13484. [PMID: 34510626]
  • Jikun Du, Daibo Song, Yuanhua Li, Jierong Liu, Xiaoman Huang, Baohong Li, Li Li. Saikosaponin-D Mitigates Oxidation in SH-SY5Y Cells Stimulated by Glutamate Through Activation of Nrf2 Pathway: Involvement of PI3K. Neurotoxicity research. 2022 Feb; 40(1):230-240. doi: 10.1007/s12640-021-00438-7. [PMID: 34994954]
  • Peng Du, Jianbin Xu, Yanfei Jiang, Jing Zhao, Chaoqun Gao, Yudie Fang, Xiaorong Yang, Yan-Ping Yang, Jin-An Zhang. Saikosaponin-d Attenuates Hashimoto's Thyroiditis by Regulating Macrophage Polarization. Journal of immunology research. 2022; 2022(?):7455494. doi: 10.1155/2022/7455494. [PMID: 36398316]
  • Yiwei Zhang, Lizhen Lin, Yushu Wang, Zhenzhen Liu, Wenxin Xia, Hong Sui, Xueyan Fu. Saikosaponin B4 Suppression Cancer Progression by Inhibiting SW480 and SW620 Cells Proliferation via the PI3K/AKT/mTOR Pathway in Colon Cancer. Current cancer drug targets. 2022; 22(11):889-903. doi: 10.2174/1568009622666220627160834. [PMID: 35762543]
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