Naproxen (BioDeep_00000398384)

代谢物信息卡片

2-(6-Methoxynaphthalen-2-yl)propanoic acid

化学式: C14H14O3 (230.0942894)
中文名称: (S)-(+)-2-(6-甲氧基-2-萘基)丙酸, (±)-2-(6-甲氧基-2-萘基)丙酸, D,L-萘普生
谱图信息: 最多检出来源 Rattus norvegicus(feces) 63.64%

分子结构信息

SMILES: CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O
InChI: InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)

描述信息

M - Musculo-skeletal system > M02 - Topical products for joint and muscular pain > M02A - Topical products for joint and muscular pain > M02AA - Antiinflammatory preparations, non-steroids for topical use
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AE - Propionic acid derivatives
G - Genito urinary system and sex hormones > G02 - Other gynecologicals > G02C - Other gynecologicals > G02CC - Antiinflammatory products for vaginal administration
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D018501 - Antirheumatic Agents > D006074 - Gout Suppressants
C471 - Enzyme Inhibitor > C1323 - Cyclooxygenase Inhibitor
D000893 - Anti-Inflammatory Agents
D004791 - Enzyme Inhibitors
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
CONFIDENCE standard compound; INTERNAL_ID 2651
CONFIDENCE standard compound; INTERNAL_ID 8544
CONFIDENCE standard compound; INTERNAL_ID 4066

同义名列表

4 个代谢物同义名

Naproxen; 2-(6-Methoxynaphthalen-2-yl)propanoic acid; 2-(6-Methoxy-2-naphthyl)propionic acid; 2-(6-methoxy-2-naphthyl)propanoic acid

数据库引用编号

41 个数据库交叉引用编号

ChEBI: CHEBI:7476
ChEBI: CHEBI:91939
KEGG: C01517
KEGGdrug: D00118
PubChem: 156391
PubChem: 1302
DrugBank: DB00788
ChEMBL: CHEMBL154
ChEMBL: CHEMBL12952
MeSH: Naproxen
CAS: 131991-52-1
CAS: 22204-53-1
CAS: 23981-80-8
CAS: 26159-31-9
MoNA: AU265106
MoNA: AU265105
MoNA: AU265104
MoNA: AU265103
MoNA: AU265102
MoNA: AU265101
MoNA: WA000361
MoNA: WA000360
MoNA: WA000359
MoNA: WA000358
MoNA: WA000357
MoNA: WA000356
MoNA: WA000355
MoNA: FiehnHILIC002873
MoNA: FiehnHILIC002170
MoNA: HMDB0001923_ms_ms_1851
MoNA: HMDB0001923_ms_ms_1850
MoNA: HMDB0001923_ms_ms_1849
MoNA: SM854403
MoNA: UF406604
MoNA: UF406603
MoNA: UF406602
MoNA: UF406601
PubChem: 4682
PDB-CCD: NPS
NIKKAJI: J9.289D
RefMet: Naproxen

分类词条

Naphthalenes

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Lili Zhang, Dingxin Wang, Jiahui Yuan, Jiazhe Chen, Tengda Ding, Tingting Zhu, Juying Li. Ecotoxicological impact of naproxen on Eisenia fetida: Unraveling soil contamination risks and the modulating role of microplastics. The Science of the total environment. 2024 Jun; 928(?):172267. doi: 10.1016/j.scitotenv.2024.172267. [PMID: 38583628]
Guodong Zhang, Zheng-Zhi Yin, Xiaoming Zuo, Haiying Chen, Guochun Chen, Jun Gao, Yong Kong. Carboxymethyl potato starch hydrogels encapsulated cyclodextrin metal-organic frameworks for enantioselective loading of S-naproxen and its programmed release. International journal of biological macromolecules. 2024 Mar; 262(Pt 1):130013. doi: 10.1016/j.ijbiomac.2024.130013. [PMID: 38340930]
Xianlu Feng, Dezhi Sun. Degradation characteristics of refractory organic matter in naproxen pharmaceutical secondary effluent using vacuum ultraviolet-ozone treatment. Journal of hazardous materials. 2023 10; 459(?):132056. doi: 10.1016/j.jhazmat.2023.132056. [PMID: 37467614]
Rasool Haddadi, Mohammad Cheraghi-Poor. Peroxisome proliferator activated receptor-gamma (PPAR-γ) ligand, pioglitazone, increases analgesic and anti-inflammatory effects of naproxen. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Sep; ?(?):. doi: 10.1007/s00210-023-02715-y. [PMID: 37698622]
Taylan Dolu, Bilgehan Nas. Dissemination of nonsteroidal anti-inflammatory drugs (NSAIDs) and metabolites from wastewater treatment plant to soils and agricultural crops via real-scale different agronomic practices. Environmental research. 2023 06; 227(?):115731. doi: 10.1016/j.envres.2023.115731. [PMID: 36958380]
Jing Xia, Mengjuan Kong, Zhisen Yang, Lianghanxiao Sun, Yakun Peng, Yanbo Mao, Hong Wei, Wei Ying, Yongxiang Gao, Jiří Friml, Jianping Weng, Xin Liu, Linfeng Sun, Shutang Tan. Chemical inhibition of Arabidopsis PIN-FORMED auxin transporters by the anti-inflammatory drug naproxen. Plant communications. 2023 May; ?(?):100632. doi: 10.1016/j.xplc.2023.100632. [PMID: 37254481]
Yi Ou, Zonglin You, Min Yao, Yingfan Cao, Xiu Xue, Min Chen, Rihui Wu, Lishe Gan, Dongli Li, Panpan Wu, Xuetao Xu, Wingleung Wong, Vincent Kam Wai Wong, Wenfeng Liu, Jiming Ye, Jingwei Jin. Naproxen-Derived New Compound Inhibits the NF-κB, MAPK and PI3K/Akt Signaling Pathways Synergistically with Resveratrol in RAW264.7 Cells. Molecules (Basel, Switzerland). 2023 Apr; 28(8):. doi: 10.3390/molecules28083395. [PMID: 37110629]
Štěpán Zezulka, Marie Kummerová, Ján Šmeringai, Petr Babula, Jan Tříska. Ambiguous changes in photosynthetic parameters of Lemna minor L. after short-term exposure to naproxen and paracetamol: Can the risk be ignored?. Aquatic toxicology (Amsterdam, Netherlands). 2023 Apr; 259(?):106537. doi: 10.1016/j.aquatox.2023.106537. [PMID: 37060818]
Natalia Rojas-Valencia, Sara Gómez, Tommaso Giovannini, Chiara Cappelli, Albeiro Restrepo, Francisco Núñez Zarur. Water Maintains the UV-Vis Spectral Features During the Insertion of Anionic Naproxen and Ibuprofen into Model Cell Membranes. The journal of physical chemistry. B. 2023 Mar; ?(?):. doi: 10.1021/acs.jpcb.2c08332. [PMID: 36877579]
Kacper Przykaza, Małgorzata Jurak, Agnieszka Ewa Wiącek. Effect of naproxen on the model lipid membrane formed on the water-chitosan subphase. Biochimica et biophysica acta. Biomembranes. 2023 03; 1865(3):184099. doi: 10.1016/j.bbamem.2022.184099. [PMID: 36493856]
Ryan Beach, Yuichiro Hatano, Yong Qiao, James Grady, Shizuko Sei, Altaf Mohammed, Daniel W Rosenberg. Combination of Naproxen and a Chemically-Stable Eicosapentaenoic Acid Analogue Provide Additive Tumor Protection in Pirc rats. International journal of cancer. 2023 Feb; ?(?):. doi: 10.1002/ijc.34459. [PMID: 36752580]
Peter Kroll, Lara Exner, Christoph Brandenbusch, Gabriele Sadowski. Influence of Hydrophobic and Hydrophilic Chain Length of CiEj Surfactants on the Solubilization of Active Pharmaceutical Ingredients. Molecular pharmaceutics. 2023 02; 20(2):1296-1306. doi: 10.1021/acs.molpharmaceut.2c00941. [PMID: 36565283]
Lucie Svobodníková, Marie Kummerová, Štěpán Zezulka, Michal Martinka, Marek Klemš, Josef Čáslavský. Pea root responses under naproxen stress: changes in the formation of structural barriers in the primary root in context with changes of auxin and abscisic acid levels. Ecotoxicology (London, England). 2023 Jan; 32(1):1-11. doi: 10.1007/s10646-022-02613-8. [PMID: 36542231]
Danuta Wojcieszyńska, Judyta Klamka, Ariel Marchlewicz, Izabela Potocka, Joanna Żur-Pińska, Urszula Guzik. Immobilized Stenotrophomonas maltophilia KB2 in Naproxen Degradation. Molecules (Basel, Switzerland). 2022 Sep; 27(18):. doi: 10.3390/molecules27185795. [PMID: 36144528]
Kathryn R Hayden, Matthew Jones, Kyle R Elkin, Michael J Shreve, William Irvin Clees, Shirley Clark, Michael L Mashtare, Tamie L Veith, Herschel A Elliott, John E Watson, Justin Silverman, Thomas L Richard, Andrew F Read, Heather E Preisendanz. Impacts of the COVID-19 pandemic on pharmaceuticals in wastewater treated for beneficial reuse: Two case studies in central Pennsylvania. Journal of environmental quality. 2022 Sep; 51(5):1066-1082. doi: 10.1002/jeq2.20398. [PMID: 35919971]
Niuosha Sanaeifar, Karsten Mäder, Dariush Hinderberger. Macro- and Nanoscale Effect of Ethanol on Bovine Serum Albumin Gelation and Naproxen Release. International journal of molecular sciences. 2022 Jul; 23(13):. doi: 10.3390/ijms23137352. [PMID: 35806356]
Ratana Leksomboon, Kamonrot Kumpangnil, Kanjana Pangjit, Latiporn Udomsuk. The Effects of Ibuprofen, Naproxen and Diclofenac on cell Apoptosis, Cell Proliferation and Histology Changes in Human Cholangiocarcinoma Cell Lines. Asian Pacific journal of cancer prevention : APJCP. 2022 Apr; 23(4):1351-1358. doi: 10.31557/apjcp.2022.23.4.1351. [PMID: 35485696]
Carla Catiúscia Ferreira Gomes, Luciana de Siqueira Oliveira, Delane C Rodrigues, Paulo Riceli Vasconcelos Ribeiro, Kirley Marques Canuto, Antoniella Souza Gomes Duarte, Kaliana Sitonio Eça, Raimundo Wilane de Figueiredo. Evidence for antioxidant and anti-inflammatory potential of mango (Mangifera indica L.) in naproxen-induced gastric lesions in rat. Journal of food biochemistry. 2022 03; 46(3):e13880. doi: 10.1111/jfbc.13880. [PMID: 34350985]
Ruiqin Zhu, Hang Mei, Huajing Liu, Changbao Hong, Xiantao Shen, Chuixiu Huang. Successive liquid-phase microextraction of acidic and basic analytes. Analytica chimica acta. 2022 Feb; 1192(?):339335. doi: 10.1016/j.aca.2021.339335. [PMID: 35057942]
Ivana Predarska, Mohamad Saoud, Ibrahim Morgan, Thomas Eichhorn, Goran N Kaluđerović, Evamarie Hey-Hawkins. Cisplatin-cyclooxygenase inhibitor conjugates, free and immobilised in mesoporous silica SBA-15, prove highly potent against triple-negative MDA-MB-468 breast cancer cell line. Dalton transactions (Cambridge, England : 2003). 2022 Jan; 51(3):857-869. doi: 10.1039/d1dt03265h. [PMID: 34877948]
Zarimah Mohd Hanafiah, Wan Hanna Melini Wan Mohtar, Teh Sabariah Binti Abd Manan, Nur Aina Bachi', Nor Azura Abdullah, Haris Hafizal Abd Hamid, Salmia Beddu, Nur Liyana Mohd Kamal, Amirrudin Ahmad, Nadiah Wan Rasdi. The occurrence of non-steroidal anti-inflammatory drugs (NSAIDs) in Malaysian urban domestic wastewater. Chemosphere. 2022 Jan; 287(Pt 2):132134. doi: 10.1016/j.chemosphere.2021.132134. [PMID: 34517236]
Masoomeh Asadi, Sara Sayar, Esmat Radmanesh, Sina Naghshi, Sajedeh Mousaviasl, Saeed Jelvay, Mona Ebrahimzadeh, Asma Mohammadi, Samaneh Abbasi, Sara Mobarak, Saeid Bitaraf, Fatemeh Zardehmehri, Ali Cheldavi. Efficacy of naproxen in the management of patients hospitalized with COVID-19 infection: A randomized, double-blind, placebo-controlled, clinical trial. Diabetes & metabolic syndrome. 2021 Nov; 15(6):102319. doi: 10.1016/j.dsx.2021.102319. [PMID: 34700294]
Barbara Pawłowska, Arkadiusz Telesiński, Robert Biczak. Effect of diclofenac and naproxen and their mixture on spring barley seedlings and Heterocypris incongruens. Environmental toxicology and pharmacology. 2021 Nov; 88(?):103746. doi: 10.1016/j.etap.2021.103746. [PMID: 34536620]
Sunkyung Jeong, Joseph E Valdez, Natalia Miękus, Joon Yub Kwon, Wooyong Kwon, Tomasz Bączek, Doo Soo Chung. Facile and highly efficient three-phase single drop microextraction in-line coupled with capillary electrophoresis. Journal of chromatography. A. 2021 Oct; 1655(?):462520. doi: 10.1016/j.chroma.2021.462520. [PMID: 34517164]
Agnieszka Siemieniuk, Michał Ludynia, Małgorzata Rudnicka. Response of Two Crop Plants, Zea mays L. and Solanum lycopersicum L., to Diclofenac and Naproxen. International journal of molecular sciences. 2021 Aug; 22(16):. doi: 10.3390/ijms22168856. [PMID: 34445561]
Monica de Gaetano, Catherine Tighe, Kevin Gahan, Andrea Zanetti, Jianmin Chen, Justine Newson, Antonino Cacace, Mariam Marai, Andrew Gaffney, Eoin Brennan, Phillip Kantharidis, Mark E Cooper, Xavier Leroy, Mauro Perretti, Derek Gilroy, Catherine Godson, Patrick J Guiry. Asymmetric Synthesis and Biological Screening of Quinoxaline-Containing Synthetic Lipoxin A4 Mimetics (QNX-sLXms). Journal of medicinal chemistry. 2021 07; 64(13):9193-9216. doi: 10.1021/acs.jmedchem.1c00403. [PMID: 34138563]
Gaurav Kumar, Venkateshwar Madka, Anil Singh, Mudassir Farooqui, Nicole Stratton, Stanley Lightfoot, Altaf Mohammed, Chinthalapally V Rao. Naproxen inhibits spontaneous lung adenocarcinoma formation in KrasG12V mice. Neoplasia (New York, N.Y.). 2021 06; 23(6):574-583. doi: 10.1016/j.neo.2021.05.010. [PMID: 34091121]
Ramesh Boinpally, John Spaventa, Kayla Chen, Matthew Butler. Evaluation of the Pharmacokinetic Interaction and Safety of Atogepant Co-Administered with Acetaminophen or Naproxen in Healthy Participants: A Randomized Trial. Clinical drug investigation. 2021 Jun; 41(6):557-567. doi: 10.1007/s40261-021-01034-5. [PMID: 33948911]
Sherin F Hammad, Basma Z El-Khateeb, Samah F El-Malla. Micelle-enhanced spectrofluorimetric determination of diphenhydramine: application to human plasma and its simultaneous determination with naproxen in pharmaceutical tablets. Luminescence : the journal of biological and chemical luminescence. 2021 May; 36(3):733-741. doi: 10.1002/bio.3996. [PMID: 33332700]
Lindsay M Henderson, Scarlett E Hopkins, Bert B Boyer, Timothy A Thornton, Allan E Rettie, Kenneth E Thummel. In Vivo Functional Effects of CYP2C9 M1L, a Novel and Common Variant in the Yup'ik Alaska Native Population. Drug metabolism and disposition: the biological fate of chemicals. 2021 05; 49(5):345-352. doi: 10.1124/dmd.120.000301. [PMID: 33632714]
Olivier Terrier, Sébastien Dilly, Andrés Pizzorno, Dominika Chalupska, Jana Humpolickova, Evžen Bouřa, Francis Berenbaum, Stéphane Quideau, Bruno Lina, Bruno Fève, Frédéric Adnet, Michèle Sabbah, Manuel Rosa-Calatrava, Vincent Maréchal, Julien Henri, Anny Slama-Schwok. Antiviral Properties of the NSAID Drug Naproxen Targeting the Nucleoprotein of SARS-CoV-2 Coronavirus. Molecules (Basel, Switzerland). 2021 Apr; 26(9):. doi: 10.3390/molecules26092593. [PMID: 33946802]
Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
Young-Kwon Park, Byung-Joo Kim, Sang-Chai Kim, Chan-Seo You, Jaewook Choi, Jaegu Park, Heon Lee, Sang-Chul Jung. Decomposition of naproxen by plasma in liquid process with TiO2 photocatslysts and hydrogen peroxide. Environmental research. 2021 04; 195(?):110899. doi: 10.1016/j.envres.2021.110899. [PMID: 33610581]
Pantea Kiani, Andrew Scholey, Thomas A Dahl, Lauren McMann, Jacqueline M Iversen, Joris C Verster. In Vitro Assessment of the Antiviral Activity of Ketotifen, Indomethacin and Naproxen, Alone and in Combination, against SARS-CoV-2. Viruses. 2021 03; 13(4):. doi: 10.3390/v13040558. [PMID: 33810356]
Yuanhang Yang, Xiaoting Li, Qi Zhou, Lingling Sun, Tianhong Zhang. Simultaneous determination of naproxen and esomeprazole in beagle dog plasma by supercritical fluid chromatography-tandem mass spectrometry coupled with evaporation-free liquid-liquid extraction. Journal of pharmaceutical and biomedical analysis. 2021 Jan; 193(?):113668. doi: 10.1016/j.jpba.2020.113668. [PMID: 33176242]
Ratana Vichiansiri, Nutjaree Pratheepawanit Johns, Amonwat Thankham, Tanit Padumanonda. Comparative Effectiveness of Thai Herbal Formula (Thor-Ra-Nee-San-Tha-Kat) Versus Naproxen for Chronic Myofascial Pain: A Pilot Randomized-Controlled Trial. Journal of alternative and complementary medicine (New York, N.Y.). 2021 Jan; 27(1):73-79. doi: 10.1089/acm.2020.0270. [PMID: 33216613]
Matthew W Eskew, Megan M Koslen, Albert S Benight. Ligand binding to natural and modified human serum albumin. Analytical biochemistry. 2021 01; 612(?):113843. doi: 10.1016/j.ab.2020.113843. [PMID: 32726582]
Linming Li, Yan Chen, Qingpeng Wang, Zuojie Li, Zhifang Liu, Xuewen Hua, Jun Han, Chunxiao Chang, Zhengping Wang, Dacheng Li. Albumin-encapsulated Nanoparticles of Naproxen Platinum(IV) Complexes with Inflammation Inhibitory Competence Displaying Effective Antitumor Activities in vitro and in vivo. International journal of nanomedicine. 2021; 16(?):5513-5529. doi: 10.2147/ijn.s322688. [PMID: 34429597]
Ibraam E Mikhail, Masoomeh Tehranirokh, Andrew A Gooley, Rosanne M Guijt, Michael C Breadmore. In-Syringe Electrokinetic Protein Removal from Biological Samples prior to Electrospray Ionization Mass Spectrometry. Angewandte Chemie (International ed. in English). 2020 12; 59(51):23162-23168. doi: 10.1002/anie.202006481. [PMID: 32869436]
Narjes Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Bushra Mdkhana, Saba Al Heialy, Elaref Ratemi, Malak Alghamdi, Salah Abusnana, Tarek Kashour, Qutayba Hamid, Rabih Halwani. Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue. Archives of toxicology. 2020 12; 94(12):4037-4041. doi: 10.1007/s00204-020-02869-1. [PMID: 32808185]
Ensieh Vahedi, Mostafa Ghanei, Ali Ghazvini, Hossein Azadi, Morteza Izadi, Yunes Panahi, Saeid Fathi, Mahmood Salesi, Seyed Hassan Saadat, Amir Hossein Ghazale, Mohammad Rezapour, Abolfazl Mozafari, Nahid Zand, Mohammadreza Raesi Parsaei, Mohammad Hossein Ranjkesh, Ramezan Jafari, Fatemeh Movaseghi, Enayat Darabi. The clinical value of two combination regimens in the Management of Patients Suffering from Covid-19 pneumonia: a single centered, retrospective, observational study. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. 2020 Dec; 28(2):507-516. doi: 10.1007/s40199-020-00353-w. [PMID: 32562159]
Joseph W Lowdon, Kasper Eersels, Rocio Arreguin-Campos, Manlio Caldara, Benjamin Heidt, Renato Rogosic, Kathia L Jimenez-Monroy, Thomas J Cleij, Hanne Diliën, Bart van Grinsven. A Molecularly Imprinted Polymer-based Dye Displacement Assay for the Rapid Visual Detection of Amphetamine in Urine. Molecules (Basel, Switzerland). 2020 Nov; 25(22):. doi: 10.3390/molecules25225222. [PMID: 33182534]
Lucie Svobodníková, Marie Kummerová, Štěpán Zezulka, Petr Babula, Katarína Sendecká. Root response in Pisum sativum under naproxen stress: Morpho-anatomical, cytological, and biochemical traits. Chemosphere. 2020 Nov; 258(?):127411. doi: 10.1016/j.chemosphere.2020.127411. [PMID: 32947668]
Folabomi A Oladosu, Frank F Tu, Ellen F Garrison, Katlyn E Dillane, Genevieve E Roth, Kevin M Hellman. Low Serum Naproxen Concentrations Are Associated with Minimal Pain Relief: A Preliminary Study in Women with Dysmenorrhea. Pain medicine (Malden, Mass.). 2020 11; 21(11):3102-3108. doi: 10.1093/pm/pnaa133. [PMID: 32488234]
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Johanna Näslund, Noomi Asker, Jerker Fick, D G Joakim Larsson, Leif Norrgren. Naproxen affects multiple organs in fish but is still an environmentally better alternative to diclofenac. Aquatic toxicology (Amsterdam, Netherlands). 2020 Oct; 227(?):105583. doi: 10.1016/j.aquatox.2020.105583. [PMID: 32835849]
Khrystyna O Semen, Rick H A van der Doelen, Monique van der Lugt, Davy G H A van Dam, Jürgen Reimer, Frank R M Stassen, Loes Janssen, Paddy K C Janssen, Marcel J W Janssen, Aalt Bast, Jos L M L le Noble. Non-steroidal anti-inflammatory drugs increase urinary neutrophil gelatinase-associated lipocalin in recreational runners. Scandinavian journal of medicine & science in sports. 2020 Oct; 30(10):1888-1895. doi: 10.1111/sms.13755. [PMID: 32585737]
Chia-Yu Chiu, Amara Sarwal, Rehan Azhar Munir, Michael Widjaja, Amna Khalid, Rajan Khanna. Syndrome of Inappropriate Antidiuretic Hormone (SIADH) Induced by Long-Term Use of Citalopram and Short-Term Use of Naproxen. The American journal of case reports. 2020 Sep; 21(?):e926561. doi: 10.12659/ajcr.926561. [PMID: 32946431]
Michael R Duff, Scott A Gabel, Lars C Pedersen, Eugene F DeRose, Juno M Krahn, Elizabeth E Howell, Robert E London. The Structural Basis for Nonsteroidal Anti-Inflammatory Drug Inhibition of Human Dihydrofolate Reductase. Journal of medicinal chemistry. 2020 08; 63(15):8314-8324. doi: 10.1021/acs.jmedchem.0c00546. [PMID: 32658475]
Motahar Heidari-Beni, Amir R Moravejolahkami, Pegah Gorgian, Gholamreza Askari, Mohammad J Tarrahi, Nimah Bahreini-Esfahani. Herbal formulation "turmeric extract, black pepper, and ginger" versus Naproxen for chronic knee osteoarthritis: A randomized, double-blind, controlled clinical trial. Phytotherapy research : PTR. 2020 Aug; 34(8):2067-2073. doi: 10.1002/ptr.6671. [PMID: 32180294]
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Keigo Nakayama, Hidetaka Kamimura, Hiroshi Suemizu, Nao Yoneda, Megumi Nishiwaki, Kazuhiko Iwamoto, Mari Mizunaga, Tamotsu Negoro, Soichiro Ito, Hiroshi Yamazaki, Yukihiro Nomura. Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data. Drug metabolism and pharmacokinetics. 2020 Aug; 35(4):389-396. doi: 10.1016/j.dmpk.2020.05.004. [PMID: 32690433]
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