VALPROIC ACID (BioDeep_00000398035)

Main id: BioDeep_00000003427

Secondary id: BioDeep_00000398034

Volatile Flavor Compounds natural product


代谢物信息卡片


2-PROPYL-pentanoIC ACID

化学式: C8H16O2 (144.1150236)
中文名称: 丙戊酸
谱图信息: 最多检出来源 Homo sapiens(blood) 0.8%

分子结构信息

SMILES: CCCC(CCC)C(=O)O
InChI: InChI=1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)

描述信息

D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D018692 - Antimanic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
N - Nervous system > N03 - Antiepileptics > N03A - Antiepileptics > N03AG - Fatty acid derivatives
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
D018377 - Neurotransmitter Agents > D018682 - GABA Agents
D004791 - Enzyme Inhibitors
KEIO_ID V004

同义名列表

5 个代谢物同义名

VALPROIC ACID; 2-PROPYL-pentanoIC ACID; Valproate(2); Valproic acid; Valproic acid



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Heba Fikry, Lobna A Saleh, Faten A Mahmoud, Sara Abdel Gawad, Hadwa Ali Abd-Alkhalek. CoQ10 targeted hippocampal ferroptosis in a status epilepticus rat model. Cell and tissue research. 2024 Jun; 396(3):371-397. doi: 10.1007/s00441-024-03880-z. [PMID: 38499882]
  • Eda Cergel, Burcin Alev Tuzuner, Ismet Burcu Turkyilmaz, Sehkar Oktay, Umar Faruk Magaji, Ozlem Sacan, Refiye Yanardag, Aysen Yarat. Reversal of Valproate-Induced Major Salivary Gland Changes By Moringa Oleifera Extract in Rats. Chemistry & biodiversity. 2024 May; 21(5):e202301959. doi: 10.1002/cbdv.202301959. [PMID: 38469951]
  • Zhuo Chen, Feng-Feng Wu, Jing Li, Jia-Bao Dong, Hong-Yi He, Xiong-Feng Li, Qian Lu, Wen-Xuan Zhang, Chang-Ming Shao, Zhao-Nong Yao, Nong Lin, Zhao-Ming Ye, Jun-Tao Xu, Heng-Yuan Li. Investigating the synergy of Shikonin and Valproic acid in inducing apoptosis of osteosarcoma cells via ROS-mediated EGR1 expression. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Apr; 126(?):155459. doi: 10.1016/j.phymed.2024.155459. [PMID: 38417243]
  • Lianyu Zhou, Peiyan Jiang, Linyang Zhao, Xinghang Fei, Yexi Tang, Yi Luo, Hong Gong, Xiaqing Wang, Xin Li, Song Li, Chunqing Zhang, Hui Yang, Xiaotang Fan. Ligustilide inhibits Purkinje cell ferritinophagy via the ULK1/NCOA4 pathway to attenuate valproic acid-induced autistic features. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Apr; 126(?):155443. doi: 10.1016/j.phymed.2024.155443. [PMID: 38394737]
  • Claire Grosu, William Hatoum, Marianna Piras, Nermine Laaboub, Setareh Ranjbar, Franziska Gamma, Kerstin J Plessen, Armin von Gunten, Martin Preisig, Philippe Conus, Chin B Eap. Associations of Valproate Doses With Weight Gain in Adult Psychiatric Patients: A 1-Year Prospective Cohort Study. The Journal of clinical psychiatry. 2024 03; 85(2):. doi: 10.4088/jcp.23m15008. [PMID: 38535509]
  • Qian Zhang, Yongjie Wang, Jie Tao, Ruixue Xia, Yijie Zhang, Zhirui Liu, Jiwei Cheng. Sex-biased single-cell genetic landscape in mice with autism spectrum disorder. Journal of genetics and genomics = Yi chuan xue bao. 2024 Mar; 51(3):338-351. doi: 10.1016/j.jgg.2023.08.012. [PMID: 37703921]
  • Yibing Zhou, Ze Chen, Hui Zhou, Bin Niu, Jing Liu, Yinglun Li, Yuqiang Mi, Ping Li. ACT001 Alleviates chronic kidney injury induced by a high-fat diet in mice through the GPR43/AMPK pathway. Lipids in health and disease. 2023 Nov; 22(1):198. doi: 10.1186/s12944-023-01949-2. [PMID: 37978497]
  • Pei Chen, Yang Yang, Yumeng Guo, Jing Li, Guishan Wang, Haining Yuan. Pleural Effusion Associated With Divalproex Sodium: A Case Report and Literature Review. Journal of clinical psychopharmacology. 2023 Nov; 43(6):541-543. doi: 10.1097/jcp.0000000000001760. [PMID: 37930211]
  • Rayara Nogueira de Freitas, Lucas Guilherme Leite da Silva, Gabriela Alice Fiais, Douglas Sandrac de Biagi Ferreira, Allice Santos Cruz Veras, Giovana Rampazzo Teixeira, Sandra Helena Penha Oliveira, Rita Cássia Menegati Dornelles, Ana Cláudia de Melo Stevanato Nakamune, Walid D Fakhouri, Antonio Hernandes Chaves-Neto. Alterations in salivary biochemical composition and redox state disruption induced by the anticonvulsant valproic acid in male rat salivary glands. Archives of oral biology. 2023 Nov; 155(?):105805. doi: 10.1016/j.archoralbio.2023.105805. [PMID: 37741048]
  • Sai Teja Meka, Sree Lalitha Bojja, Gautam Kumar, Sumit Raosaheb Birangal, C Mallikarjuna Rao. Novel HDAC inhibitors provide neuroprotection in MPTP-induced Parkinson's disease model of rats. European journal of pharmacology. 2023 Sep; 959(?):176067. doi: 10.1016/j.ejphar.2023.176067. [PMID: 37751833]
  • David Jutrić, Domagoj Đikić, Almoš Boroš, Dyana Odeh, Romana Gračan, Anđelo Beletić, Irena Landeka Jurčević. Combined effects of valproate and naringin on kidney antioxidative markers and serum parameters of kidney function in C57BL6 mice. Arhiv za higijenu rada i toksikologiju. 2023 Sep; 74(3):218-223. doi: 10.2478/aiht-2023-74-3764. [PMID: 37791674]
  • Peiyan Jiang, Lianyu Zhou, Linyang Zhao, Xinghang Fei, Zhifei Wang, Tianyao Liu, Yexi Tang, Dabing Li, Hong Gong, Yi Luo, Song Li, Hui Yang, Huiling Liao, Xiaotang Fan. Puerarin attenuates valproate-induced features of ASD in male mice via regulating Slc7a11-dependent ferroptosis. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023 Jul; ?(?):. doi: 10.1038/s41386-023-01659-4. [PMID: 37491673]
  • Valentine Turpin, Maud Schaffhauser, Mathieu Thabault, Agnès Aubert, Corinne Joffre, Eric Balado, Jean-Emmanuel Longueville, Maureen Francheteau, Christophe Burucoa, Maxime Pichon, Sophie Layé, Mohamed Jaber. Mice prenatally exposed to valproic acid do not show autism-related disorders when fed with polyunsaturated fatty acid-enriched diets. Scientific reports. 2023 07; 13(1):11235. doi: 10.1038/s41598-023-38423-z. [PMID: 37433863]
  • Ashley L Muller, Luisa Diaz-Arias, Mackenzie C Cervenka, Tanya J W McDonald. The effect of anti-seizure medications on lipid values in adults with epilepsy. Epilepsy & behavior : E&B. 2023 Jul; 144(?):109260. doi: 10.1016/j.yebeh.2023.109260. [PMID: 37244221]
  • Hong-Li Guo, Wei-Jun Wang, Na Dong, Yue-Tao Zhao, Hao-Ran Dai, Ya-Hui Hu, Yuan-Yuan Zhang, Jie Wang, Jin-Chun Qiu, Xiao-Peng Lu, Feng Chen. Integrating metabolomics and lipidomics revealed a decrease in plasma fatty acids but an increase in triglycerides in children with drug-refractory epilepsy. Epilepsia open. 2023 06; 8(2):466-478. doi: 10.1002/epi4.12712. [PMID: 36808532]
  • Sweety Mehra, Aitizaz Ul Ahsan, Madhu Sharma, Muskan Budhwar, Mani Chopra. Neuroprotective Efficacy of Fisetin Against VPA-Induced Autistic Neurobehavioral Alterations by Targeting Dysregulated Redox Homeostasis. Journal of molecular neuroscience : MN. 2023 Jun; ?(?):. doi: 10.1007/s12031-023-02127-w. [PMID: 37261645]
  • Mehmet Alper Arslan, Özgür Korhan Tunçel, Birşen Bilgici, Arzu Karaustaoğlu, Taner İlker Gümrükçüoğlu. Increased levels of lipid and protein oxidation in rat prefrontal cortex after treatment by lithium, valproic acid, and olanzapine. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Apr; ?(?):. doi: 10.1007/s00210-023-02494-6. [PMID: 37093250]
  • Q U Dongxiao, G E Yiqin, Zhuo Limin, Chen Liji, Xue Yonghua, Cheng Jiwei, Tao Jie, L I Guoyi, Zhu Yudan, Xiao Qian. Efficacy and mechanisms of Dingxian pill combined with valproic acid on pentylenetetrazol-induced chronic epilepsy in rats. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2023 Apr; 43(2):286-294. doi: 10.19852/j.cnki.jtcm.20220928.002. [PMID: 36994516]
  • Sara Haratizadeh, Mehdi Ranjbar, Mohsen Basiri, Masoumeh Nozari. Astrocyte responses to postnatal erythropoietin and nano-erythropoietin treatments in a valproic acid-induced animal model of autism. Journal of chemical neuroanatomy. 2023 Mar; 130(?):102257. doi: 10.1016/j.jchemneu.2023.102257. [PMID: 36918074]
  • Nan Zhang, Shu-Ting Wang, Lei Yao. Inhalation of Cananga odorata essential oil relieves anxiety behaviors in autism-like rats via regulation of serotonin and dopamine metabolism. Journal of integrative medicine. 2023 03; 21(2):205-214. doi: 10.1016/j.joim.2023.01.006. [PMID: 36792414]
  • Arief Hidayatullah, Wira E Putra, Sustiprijatno Sustiprijatno, Muhaimin Rifa'i, Diana Widiastuti, Muhammad F Heikal, Galuh W Permatasari. Concatenation of molecular docking and dynamics simulation of human papillomavirus type 16 E7 oncoprotein targeted ligands: In quest of cervical cancer's treatment. Anais da Academia Brasileira de Ciencias. 2023; 95(suppl 1):e20220633. doi: 10.1590/0001-3765202320220633. [PMID: 37466536]
  • Wenfang Song, Xinrui Yan, Yu Zhai, Jing Ren, Ting Wu, Han Guo, Yu Song, Xiaojiao Li, Yingjie Guo. Probiotics attenuate valproate-induced liver steatosis and oxidative stress in mice. PloS one. 2023; 18(11):e0294363. doi: 10.1371/journal.pone.0294363. [PMID: 37971986]
  • Ling Yang, Tung-Hu Tsai. Neuroprotective effect and herbal-drug pharmacokinetic interaction of Gastrodia elata extract on valproic acid. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Dec; 156(?):113938. doi: 10.1016/j.biopha.2022.113938. [PMID: 36411625]
  • Asmaa A Mahmoud, Hesham M Aboelghar, Sabry Moawad Abdelmageed, Heba M Abdallah, Mohamed I Garib, Nahla M S Abd El Hady. Assessment of asymmetric dimethylarginine and homocysteine in epileptic children receiving antiepileptic drugs. Pediatric research. 2022 12; 92(6):1606-1612. doi: 10.1038/s41390-022-02132-6. [PMID: 35688962]
  • Shuguang Du, Xuanyu Wang, Ye Hu, Shuxian Zhang, Dan Wang, Qinggao Zhang, Shuangping Liu. Valproic acid regulates MIEF1 through MST2-HIPPO to suppress breast cancer growth. Life sciences. 2022 Nov; 309(?):120976. doi: 10.1016/j.lfs.2022.120976. [PMID: 36126724]
  • Onur Ertik, Umar Faruk Magaji, Ozlem Sacan, Refiye Yanardag. Effect of Moringa oleifera leaf extract on valproate-induced oxidative damage in muscle. Drug and chemical toxicology. 2022 Nov; ?(?):1-11. doi: 10.1080/01480545.2022.2144876. [PMID: 36373188]
  • Wenliang Feng, Xuebin Jiang, Rujiang Zhang, Zhendong Guo, Daiquan Gao. Diagnosis of an Acinetobacter pittii from a patient in China with a multiplex PCR-based targeted gene sequencing platform of the cerebrospinal fluid: A case report with literature review. Medicine. 2022 Oct; 101(42):e31130. doi: 10.1097/md.0000000000031130. [PMID: 36281177]
  • Hong-Li Guo, Na Dong, Feng Chen, Yuan-Yuan Zeng, Ya-Hui Hu, Ying Xia, Man Tian, Xiao-Peng Lu, Jin-Chun Qiu. Effect of long-term valproic acid therapy on lipid profiles in paediatric patients with epilepsy: a meta-analysis. Epileptic disorders : international epilepsy journal with videotape. 2022 10; 24(5):1-9. doi: 10.1684/epd.2022.1460. [PMID: 35816100]
  • T Cantelmi, E Lepore, V R Unfer, V Unfer. Safety of inositol supplementation in patients taking lithium or valproic acid: a pilot clinical study. European review for medical and pharmacological sciences. 2022 10; 26(19):7269-7276. doi: 10.26355/eurrev_202210_29920. [PMID: 36263538]
  • Antoine Kavaye Kandeda, Saleh Nodeina, Symphorien Talom Mabou. An aqueous extract of Syzygium cumini protects against kainate-induced status epilepticus and amnesia: evidence for antioxidant and anti-inflammatory intervention. Metabolic brain disease. 2022 10; 37(7):2581-2602. doi: 10.1007/s11011-022-01052-y. [PMID: 35916986]
  • Devaraj Ezhilarasan, Uthirappan Mani. Valproic acid induced liver injury: An insight into molecular toxicological mechanism. Environmental toxicology and pharmacology. 2022 Oct; 95(?):103967. doi: 10.1016/j.etap.2022.103967. [PMID: 36058508]
  • Xiang Zou, Zilu Zhu, Yu Guo, Hongmiao Zhang, Yuchen Liu, Zhengyu Cui, Zunji Ke, Shize Jiang, Yusheng Tong, Zehan Wu, Ying Mao, Liang Chen, Deheng Wang. Neural excitatory rebound induced by valproic acid may predict its inadequate control of seizures. EBioMedicine. 2022 Sep; 83(?):104218. doi: 10.1016/j.ebiom.2022.104218. [PMID: 35970021]
  • Hanbin Chen, Shirley Weng In Siu, Clarence Tsun Ting Wong, Jianwen Qiu, Alex Kwok-Kuen Cheung, Simon Ming Yuen Lee. Anti-epileptic Kunitz-like peptides discovered in the branching coral Acropora digitifera through transcriptomic analysis. Archives of toxicology. 2022 09; 96(9):2589-2608. doi: 10.1007/s00204-022-03311-4. [PMID: 35604417]
  • Miyuki Takahashi, Toshiyuki Takasugi, Arisa Kawakami, Ran Wei, Kanae Ando, Toshio Ohshima, Shin-Ichi Hisanaga. Valproic Acid-Induced Anxiety and Depression Behaviors are Ameliorated in p39 Cdk5 Activator-Deficient Mice. Neurochemical research. 2022 Sep; 47(9):2773-2779. doi: 10.1007/s11064-022-03642-9. [PMID: 35674931]
  • Mishra Abhishek, Singla Rubal, Kumar Rohit, Joshi Rupa, Sarma Phulen, Kaur Gurjeet, Sharma Amit Raj, Prajapat Manisha, Bhatia Alka, Pallola Ramprasad, Medhi Bikash. Neuroprotective effect of the standardised extract of Bacopa monnieri (BacoMind) in valproic acid model of autism spectrum disorder in rats. Journal of ethnopharmacology. 2022 Jul; 293(?):115199. doi: 10.1016/j.jep.2022.115199. [PMID: 35346813]
  • Livia J De Picker, Marion Leboyer, John R Geddes, Manuel Morrens, Paul J Harrison, Maxime Taquet. Association between serum lithium level and incidence of COVID-19 infection. The British journal of psychiatry : the journal of mental science. 2022 07; 221(1):425-427. doi: 10.1192/bjp.2022.42. [PMID: 35318909]
  • Yiqian Chen, Jingzhen Chen, Xiaorong Zhuang, Xingyu Chen, Jianqi Zeng, Ru Wang, Jiayin Miao. Risk factors of elevated blood ammonia level in epilepsy patients treated with lamotrigine. Medicine. 2022 Jul; 101(26):e29780. doi: 10.1097/md.0000000000029780. [PMID: 35776999]
  • Fatih Mehmet Kandemir, Mustafa Ileriturk, Cihan Gur. Rutin protects rat liver and kidney from sodium valproate-induce damage by attenuating oxidative stress, ER stress, inflammation, apoptosis and autophagy. Molecular biology reports. 2022 Jul; 49(7):6063-6074. doi: 10.1007/s11033-022-07395-0. [PMID: 35352204]
  • Cangsang Song, Xingde Li, Panpan Mao, Wenbing Song, Lu Liu, Yang Zhang. Impact of CYP2C19 and CYP2C9 gene polymorphisms on sodium valproate plasma concentration in patients with epilepsy. European journal of hospital pharmacy : science and practice. 2022 07; 29(4):198-201. doi: 10.1136/ejhpharm-2020-002367. [PMID: 32868386]
  • Hiie Soeorg, Eva Sverrisdóttir, Morten Andersen, Trine Meldgaard Lund, Maurizio Sessa. Artificial Neural Network vs. Pharmacometric Model for Population Prediction of Plasma Concentration in Real-World Data: A Case Study on Valproic Acid. Clinical pharmacology and therapeutics. 2022 06; 111(6):1278-1285. doi: 10.1002/cpt.2577. [PMID: 35263452]
  • Muhammad Omer Iqbal, Majid Manzoor, Asma Mumtaz, Romana Riaz, Shafia Arshad, Imran Ahmad Khan, Usman Javaid, Zahid Manzoor, Shaukat Hussain Munawar, Shumaila Andleeb, Muhammad Masood Ahmed, Aqsa Aslam. Evaluation of the hepatoprotective activity of hydroalcoholic extract of Alhagi camelorum against valproic acid-induced hepatotoxicity in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jun; 150(?):112953. doi: 10.1016/j.biopha.2022.112953. [PMID: 35430391]
  • Z Shnewer Mahdi Al-Turfi, S M J Al-Hadrawy, J Abadi Mohammed, B Chasib Jabal. Evaluation of the Effect of Alcoholic Extract of Laurus Nobilis Leaves on Blood Biochemical Parameters and Histological Changes in the Liver and Kidney among Female Wistar Rats Treated with Depakene (Sodium Valproate). Archives of Razi Institute. 2022 06; 77(3):981-989. doi: 10.22092/ari.2022.357272.2011. [PMID: 36618289]
  • Yang Xu, Yameng Wang, Lulu Wang, Wenxing Liang, Qianqian Yang. Sodium Valproate Is Effective Against Botrytis cinerea Infection of Tomato by Enhancing Histone H3 Acetylation-Directed Gene Transcription and Triggering Tomato Fruit Immune Response. Phytopathology. 2022 Jun; 112(6):1264-1272. doi: 10.1094/phyto-11-21-0483-r. [PMID: 34982575]
  • Tomohito Mizuno, Riku Takahashi, Takahiro Kamiyama, Atsushi Suzuki, Masashi Suzuki. Neuroleptic Malignant Syndrome with Adrenal Insufficiency After BNT162b2 COVID-19 Vaccination in a Man Taking Valproate: A Case Report. The American journal of case reports. 2022 May; 23(?):e936217. doi: 10.12659/ajcr.936217. [PMID: 35514081]
  • Katlyn Nemani, Sharifa Z Williams, Mark Olfson, Emily Leckman-Westin, Molly Finnerty, Jammie Kammer, Thomas E Smith, Daniel J Silverman, Jean-Pierre Lindenmayer, Gillian Capichioni, James Clelland, Donald C Goff. Association Between the Use of Psychotropic Medications and the Risk of COVID-19 Infection Among Long-term Inpatients With Serious Mental Illness in a New York State-wide Psychiatric Hospital System. JAMA network open. 2022 05; 5(5):e2210743. doi: 10.1001/jamanetworkopen.2022.10743. [PMID: 35522282]
  • McKenzie R Young, Elizabeth K Bisaccia, Lubov Romantseva, Sara W Hovey. Valproic Acid Serum Concentration and Incidence of Toxicity in Pediatric Patients. Journal of child neurology. 2022 May; 37(6):461-470. doi: 10.1177/08830738221083480. [PMID: 35253521]
  • Gustavo D Mendes, Claudiney Cheli Lotufo, Renan Arthur Bosio-Guimarães, Heleson Alves de Castro, Tainah Babadopulos, André Ricardo Ribas Freitas, Natalícia de Jesus Antunes, Gilberto De Nucci. Comparative bioavailability study with two sodium valproate tablet formulations administered under fasting conditions in healthy subjects. International journal of clinical pharmacology and therapeutics. 2022 May; 60(5):232-241. doi: 10.5414/cp203961. [PMID: 35343430]
  • Amira Ebrahim Alsemeh, Marwa Mahmood Ahmed, Amal Fawzy, Walaa Samy, Marwa Tharwat, Samar Rezq. Vitamin E rescues valproic acid-induced testicular injury in rats: Role of autophagy. Life sciences. 2022 May; 296(?):120434. doi: 10.1016/j.lfs.2022.120434. [PMID: 35227771]
  • Ahmad Salimi, Nasrin Alyan, Nasim Akbari, Zhaleh Jamali, Jalal Pourahmad. Selenium and L-carnitine protects from valproic acid-Induced oxidative stress and mitochondrial damages in rat cortical neurons. Drug and chemical toxicology. 2022 May; 45(3):1150-1157. doi: 10.1080/01480545.2020.1810259. [PMID: 32885679]
  • Berk Can Kantarci, Ahmet Sanli, Seyhmus Gavas, Aylin Toplu, Zehra Nur Turgan Asik, Ozlem Tugce Cilingir-Kaya, Medine Gulcebi Idrizoglu, Feriha Ercan, Filiz Onat. Effects of in utero exposure to valproate or levetiracetam on the seizures and newborn histopathology of genetic absence epilepsy rats. Neuroscience letters. 2022 04; 776(?):136574. doi: 10.1016/j.neulet.2022.136574. [PMID: 35271996]
  • David Jutrić, Domagoj Đikić, Almoš Boroš, Dyna Odeh, Sandra Domjanić Drozdek, Romana Gračan, Petar Dragičević, Irena Crnić, Irena Landeka Jurčević. Effects of naringin and valproate interaction on liver steatosis and dyslipidaemia parameters in male C57BL6 mice. Arhiv za higijenu rada i toksikologiju. 2022 Apr; 73(1):71-82. doi: 10.2478/aiht-2022-73-3608. [PMID: 35390239]
  • Jacopo Pruccoli, Antonia Parmeggiani. Inpatient treatment of anorexia nervosa with adjunctive valproate: a case series of 14 young and adolescent patients. Eating and weight disorders : EWD. 2022 Apr; 27(3):1209-1215. doi: 10.1007/s40519-021-01260-y. [PMID: 34196948]
  • Simona Dedoni, Alessandra Olianas, Barbara Manconi, Maria Collu, Barbara Tuveri, Maria Elena Vincis, Maria C Olianas, Pierluigi Onali. Upregulation of p75NTR by Histone Deacetylase Inhibitors Sensitizes Human Neuroblastoma Cells to Targeted Immunotoxin-Induced Apoptosis. International journal of molecular sciences. 2022 Mar; 23(7):. doi: 10.3390/ijms23073849. [PMID: 35409209]
  • Simon Pale, Sidiki Neteydji, Germain Sotoing Taiwe, Nadège Kouemou Emegam, Elisabeth Ngo Bum. Anticonvulsant effects of Cymbopogon giganteus extracts with possible effects on fully kindled seizures and anxiety in experimental rodent model of mesio-temporal epilepsy induced by pilocarpine. Journal of ethnopharmacology. 2022 Mar; 286(?):114863. doi: 10.1016/j.jep.2021.114863. [PMID: 34838617]
  • Amir-Mohammad Yaryari, Mehrdokht Mazdeh, Mojdeh Mohammadi, Alireza Rastgoo Haghi, Masood Ghiasian, Maryam Mehrpooya. Evaluation of serum levels of asprosin and other metabolic profiles in patients with idiopathic tonic-clonic generalized epilepsy on treatment with valproic acid. European journal of clinical pharmacology. 2022 Mar; 78(3):393-403. doi: 10.1007/s00228-022-03279-1. [PMID: 35059757]
  • Satoru Kudose, Marissa Lipton, Namrata G Jain, Vivette D D'Agati. Valproic acid-associated proximal tubulopathy. Kidney international. 2022 Mar; 101(3):653. doi: 10.1016/j.kint.2021.08.005. [PMID: 35190045]
  • Majid Marjani, Neda Dolab, Mohammad Zaman Kamkar, Taghi Amiriani, Jale Yuzugulen, Abdoljalal Marjani. Gender and Body Mass Index-Related Serum Level of Adipokines and Metabolic Syndrome Components in Bipolar Patients Who Received Lithium and Valproic Acid. Metabolic syndrome and related disorders. 2022 03; 20(2):79-87. doi: 10.1089/met.2021.0078. [PMID: 34874780]
  • Jose de Leon, Georgios Schoretsanitis, Robert L Smith, Espen Molden, Anssi Solismaa, Niko Seppälä, Miloslav Kopeček, Patrik Švancer, Ismael Olmos, Carina Ricciardi, Celso Iglesias-Garcia, Ana Iglesias-Alonso, Edoardo Spina, Can-Jun Ruan, Chuan-Yue Wang, Gang Wang, Yi-Lang Tang, Shih-Ku Lin, Hsien-Yuan Lane, Yong Sik Kim, Se Hyun Kim, Anto P Rajkumar, Dinora F González-Esquivel, Helgi Jung-Cook, Trino Baptista, Christopher Rohde, Jimmi Nielsen, Hélène Verdoux, Clelia Quiles, Emilio J Sanz, Carlos De Las Cuevas, Dan Cohen, Peter F J Schulte, Aygün Ertuğrul, A Elif Anıl Yağcıoğlu, Nitin Chopra, Betsy McCollum, Charles Shelton, Robert O Cotes, Arun R Kaithi, John M Kane, Saeed Farooq, Chee H Ng, John Bilbily, Christoph Hiemke, Carlos López-Jaramillo, Ian McGrane, Fernando Lana, Chin B Eap, Manuel Arrojo-Romero, Flavian Ş Rădulescu, Erich Seifritz, Susanna Every-Palmer, Chad A Bousman, Emmanuel Bebawi, Rahul Bhattacharya, Deanna L Kelly, Yuji Otsuka, Judit Lazary, Rafael Torres, Agustin Yecora, Mariano Motuca, Sherry K W Chan, Monica Zolezzi, Sami Ouanes, Domenico De Berardis, Sandeep Grover, Ric M Procyshyn, Richard A Adebayo, Oleg O Kirilochev, Andrey Soloviev, Konstantinos N Fountoulakis, Alina Wilkowska, Wiesław J Cubała, Muhammad Ayub, Alzira Silva, Raphael M Bonelli, José M Villagrán-Moreno, Benedicto Crespo-Facorro, Henk Temmingh, Eric Decloedt, Maria R Pedro, Hiroyoshi Takeuchi, Masaru Tsukahara, Gerhard Gründer, Marina Sagud, Andreja Celofiga, Dragana Ignjatovic Ristic, Bruno B Ortiz, Helio Elkis, António J Pacheco Palha, Adrián LLerena, Emilio Fernandez-Egea, Dan Siskind, Abraham Weizman, Rim Masmoudi, Shamin Mohd Saffian, Jonathan G Leung, Peter F Buckley, Stephen R Marder, Leslie Citrome, Oliver Freudenreich, Christoph U Correll, Daniel J Müller. An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels. Pharmacopsychiatry. 2022 Mar; 55(2):73-86. doi: 10.1055/a-1625-6388. [PMID: 34911124]
  • Yan-Nan Zang, Wei Guo, Meng-Xi Niu, Shuang Bao, Qian Wang, Yan Wang, Fang Dong, An-Ning Li, Can-Jun Ruan. Population pharmacokinetics of valproic acid in adult Chinese patients with bipolar disorder. European journal of clinical pharmacology. 2022 Mar; 78(3):405-418. doi: 10.1007/s00228-021-03246-2. [PMID: 34854947]
  • Yamei Qiao, Yunyan Zhao, Gui Wang, Yuanyuan Song, Zilin Wei, Min Jin, Dong Yang, Jing Yin, Junwen Li, Weili Liu. Protection from benzene-induced immune dysfunction in mice. Toxicology. 2022 02; 468(?):153103. doi: 10.1016/j.tox.2022.153103. [PMID: 35090963]
  • Yao Jiang, Andrew D Southam, Sandro Trova, Flavio Beke, Bader Alhazmi, Thomas Francis, Anshul Radotra, Alessandro di Maio, Mark T Drayson, Chris M Bunce, Farhat L Khanim. Valproic acid disables the Nrf2 anti-oxidant response in acute myeloid leukaemia cells enhancing reactive oxygen species-mediated killing. British journal of cancer. 2022 02; 126(2):275-286. doi: 10.1038/s41416-021-01570-z. [PMID: 34686779]
  • Diandra A Licon, Lusha Xiang. Letter Regarding: Valproic Acid Protects Against Acute Kidney Injury in Hemorrhage and Trauma. The Journal of surgical research. 2022 02; 270(?):530-531. doi: 10.1016/j.jss.2021.09.044. [PMID: 34808471]
  • Youyu Gu, Ying Han, Shimeng Ren, Bi Zhang, Yihan Zhao, Xiaoxi Wang, Shaobin Zhang, Jiong Qin. Correlation among gut microbiota, fecal metabolites and autism-like behavior in an adolescent valproic acid-induced rat autism model. Behavioural brain research. 2022 01; 417(?):113580. doi: 10.1016/j.bbr.2021.113580. [PMID: 34555431]
  • Hyang Yeon Kim, Yong-Jae Lee, Sun Jae Kim, Jung Dae Lee, Suhkmann Kim, Mee Jung Ko, Ji-Woon Kim, Chan Young Shin, Kyu-Bong Kim. Metabolomics profiling of valproic acid-induced symptoms resembling autism spectrum disorders using 1H NMR spectral analysis in rat model. Journal of toxicology and environmental health. Part A. 2022 01; 85(1):1-13. doi: 10.1080/15287394.2021.1967821. [PMID: 34445937]
  • Eman Refaat Youness, Mones M Abu Shady, Ali Abd Elaziz, Esam Galal, Mohamed El-Sonbaty, Marwa M El-Sonbaty, Mahmoud M Masoud, Walaa Alsharany Abu Elhamd. Association of folic acid, vitamin B12, and intelligence scores in epileptic children. Applied neuropsychology. Child. 2022 Jan; 11(1):45-49. doi: 10.1080/21622965.2020.1747020. [PMID: 32356452]
  • Yahao Gao, Di Jiang, Changshui Wang, Gang An, Li Zhu, Changmeng Cui. Comprehensive Analysis of Metabolic Changes in Male Mice Exposed to Sodium Valproate Based on GC-MS Analysis. Drug design, development and therapy. 2022; 16(?):1915-1930. doi: 10.2147/dddt.s357530. [PMID: 35747443]
  • Robert Løvsletten Smith, Birgit M Wollmann, Lennart Kyllesø, Thu Thuy Anh Tran, Marit Tveito, Espen Molden. Effect of Valproic Acid on the Metabolic Spectrum of Clozapine in Patients With Schizophrenia. Journal of clinical psychopharmacology. 2022 Jan; 42(1):43-50. doi: 10.1097/jcp.0000000000001507. [PMID: 34928560]
  • Gia Melikishvili, Thierry Bienvenu, Nazhi Tabatadze, Tamar Gachechiladze, Ekaterine Kurua, Sopio Gverdtsiteli, Mariam Melikishvili, Olivier Dulac. Novel UBE3A pathogenic variant in a large Georgian family produces non-convulsive status epilepticus responsive to ketogenic diet. Seizure. 2022 Jan; 94(?):70-73. doi: 10.1016/j.seizure.2021.11.012. [PMID: 34872019]
  • Julio Collazos, Pere Domingo, Nerio Fernández-Araujo, Elia Asensi-Díaz, Helem Vilchez-Rueda, Antonio Lalueza, Emilia Roy-Vallejo, Rosa Blanes, Manuel Raya-Cruz, Jaime Sanz-Cánovas, Arturo Artero, José-Manuel Ramos-Rincón, Carlos Dueñas-Gutiérrez, José Luis Lamas-Ferreiro, Víctor Asensi. Exposure to valproic acid is associated with less pulmonary infiltrates and improvements in diverse clinical outcomes and laboratory parameters in patients hospitalized with COVID-19. PloS one. 2022; 17(1):e0262777. doi: 10.1371/journal.pone.0262777. [PMID: 35085321]
  • Wassim Nasreddine, Samir F Atweh, Adnan A Beydoun, Maya Dirani, Omar Nawfal, Ahmad Beydoun. Predicting the occurrence of thrombocytopenia from free valproate levels: A prospective study. Seizure. 2022 Jan; 94(?):33-38. doi: 10.1016/j.seizure.2021.11.018. [PMID: 34864249]
  • Chen Qi Zhang, Xue Yang Bai, Yong Wan, Hong Yan Li, Hongbin Sun. Efficacy, safety, and retention rate of extended-release divalproex versus conventional delayed-release divalproex: A protocol for systematic review and meta-analysis. Medicine. 2021 Dec; 100(50):e28290. doi: 10.1097/md.0000000000028290. [PMID: 34918705]
  • Katsuyuki Tanabe, Natsumi Matsuoka-Uchiyama, Tomoyo Mifune, Chieko Kawakita, Hitoshi Sugiyama, Jun Wada. Management of corticosteroid-dependent eosinophilic interstitial nephritis: A case report. Medicine. 2021 Dec; 100(50):e28252. doi: 10.1097/md.0000000000028252. [PMID: 34918693]
  • Xiang Qiu, Lv Zhu, Huan Wang, Yan Tan, Zhuang Yang, Linyu Yang, Li Wan. From natural products to HDAC inhibitors: An overview of drug discovery and design strategy. Bioorganic & medicinal chemistry. 2021 12; 52(?):116510. doi: 10.1016/j.bmc.2021.116510. [PMID: 34826681]
  • Anusara Aranarochana, Soraya Kaewngam, Tanaporn Anosri, Apiwat Sirichoat, Wanassanun Pannangrong, Peter Wigmore, Jariya Umka Welbat. Hesperidin Reduces Memory Impairment Associated with Adult Rat Hippocampal Neurogenesis Triggered by Valproic Acid. Nutrients. 2021 Dec; 13(12):. doi: 10.3390/nu13124364. [PMID: 34959916]
  • Veedamali S Subramanian, Trevor Teafatiller, Hamid Moradi, Jonathan S Marchant. Histone deacetylase inhibitors regulate vitamin C transporter functional expression in intestinal epithelial cells. The Journal of nutritional biochemistry. 2021 12; 98(?):108838. doi: 10.1016/j.jnutbio.2021.108838. [PMID: 34403723]
  • Rajpushpa Labh, Rachna Gupta, Manish Narang, Sumita Halder, Rajarshi Kar. Effect of valproate and add-on levetiracetam on inflammatory biomarkers in children with epilepsy. Epilepsy & behavior : E&B. 2021 12; 125(?):108358. doi: 10.1016/j.yebeh.2021.108358. [PMID: 34717170]
  • Fatma Şimşek, Mustafa Ceylan, Ahmet Kızıltunç, İbrahim İyigün. The correlation between carbamazepine and valproic acid monotherapy with serum adiponectin and carnitine. Acta neurologica Belgica. 2021 Dec; 121(6):1823-1830. doi: 10.1007/s13760-020-01552-7. [PMID: 33242193]
  • Xikun Wu, Haoran Li, Weichong Dong, Xiuling Yang, Yiran Jin, Ying Gong, Zhiqing Zhang, Xiujv Liu. Determination of Free Valproic Acid Concentration in 569 Clinical Samples by LC-MS/MS After Hollow Fiber Centrifugal Ultrafiltration Treatment. Therapeutic drug monitoring. 2021 12; 43(6):789-796. doi: 10.1097/ftd.0000000000000903. [PMID: 33990504]
  • S Wang, J Li, M Song, P Yan, X Ju, J Liu, C Wang, J Shi. Effect of CYP2C19 polymorphisms on serum valproic level acid in Chinese Han patients with schizophrenia. Scientific reports. 2021 11; 11(1):23150. doi: 10.1038/s41598-021-02628-x. [PMID: 34848811]
  • Xiaobu Lan, Kai Mo, Li Nong, Yi He, Yuhong Sun. Factors Influencing Sodium Valproate Serum Concentrations in Patients with Epilepsy Based on Logistic Regression Analysis. Medical science monitor : international medical journal of experimental and clinical research. 2021 Nov; 27(?):e934275. doi: 10.12659/msm.934275. [PMID: 34776507]
  • Huseyin Kilic, Atalay Demirel, Serap Uysal. The effects of valproate on serum leptin, insulin, and lipid levels in epileptic children. Pediatrics international : official journal of the Japan Pediatric Society. 2021 Nov; 63(11):1351-1356. doi: 10.1111/ped.14674. [PMID: 33657654]
  • Megan F Hunt, Katharine T Clark, Michael C Grant, Chun Woo Choi, Glenn Whitman, Sung-Min Cho, Salia Farrokh. Therapeutic drug monitoring of valproic acid in extracorporeal membrane oxygenation. Perfusion. 2021 11; 36(8):868-872. doi: 10.1177/0267659120972272. [PMID: 33198577]
  • Glenn K Wakam, Ben E Biesterveld, Manjunath P Pai, Michael T Kemp, Rachel L O'Connell, Krishani K Rajanayake, Kiril Chtraklin, Claire A Vercruysse, Hasan B Alam. A single dose of valproic acid improves neurologic recovery and decreases brain lesion size in swine subjected to an isolated traumatic brain injury. The journal of trauma and acute care surgery. 2021 11; 91(5):867-871. doi: 10.1097/ta.0000000000003136. [PMID: 34695064]
  • Antoine Kavaye Kandeda, Fleur Clarisse Okomolo Moto, Rigobert Espoir Mbomo Ayissi, Jean Pierre Omam Omam, Lucie Ojong, Elisabeth Ngo Bum. Pergularia daemia hydro-ethanolic extract protects against pentylenetetrazole kindling-induced seizures, oxidative stress, and neuroinflammation in mice. Journal of ethnopharmacology. 2021 Oct; 279(?):114338. doi: 10.1016/j.jep.2021.114338. [PMID: 34144196]
  • Marite Punapart, Kadri Seppa, Toomas Jagomäe, Mailis Liiv, Riin Reimets, Silvia Kirillov, Allen Kaasik, Lieve Moons, Lies De Groef, Anton Terasmaa, Eero Vasar, Mario Plaas. The Expression of RAAS Key Receptors, Agtr2 and Bdkrb1, Is Downregulated at an Early Stage in a Rat Model of Wolfram Syndrome. Genes. 2021 10; 12(11):. doi: 10.3390/genes12111717. [PMID: 34828323]
  • Maral Aminpour, Williams Ernesto Miranda Delgado, Soren Wacker, Sergey Noskov, Michael Houghton, D Lorne J Tyrrell, Jack A Tuszynski. Computational determination of toxicity risks associated with a selection of approved drugs having demonstrated activity against COVID-19. BMC pharmacology & toxicology. 2021 10; 22(1):61. doi: 10.1186/s40360-021-00519-5. [PMID: 34674775]
  • Maria Laura Saiz, Marta L DeDiego, Darío López-García, Viviana Corte-Iglesias, Aroa Baragaño Raneros, Ivan Astola, Victor Asensi, Carlos López-Larrea, Beatriz Suarez-Alvarez. Epigenetic targeting of the ACE2 and NRP1 viral receptors limits SARS-CoV-2 infectivity. Clinical epigenetics. 2021 10; 13(1):187. doi: 10.1186/s13148-021-01168-5. [PMID: 34635175]
  • Ling Yang, I-Hsin Lin, Chin-Tsung Ting, Tung-Hu Tsai. Modulation of the transport of valproic acid through the blood-brain barrier in rats by the Gastrodia elata extracts. Journal of ethnopharmacology. 2021 Oct; 278(?):114276. doi: 10.1016/j.jep.2021.114276. [PMID: 34082013]
  • Conghui Zhou, Songfeng Hu, Benson O A Botchway, Yong Zhang, Xuehong Liu. Valproic Acid: A Potential Therapeutic for Spinal Cord Injury. Cellular and molecular neurobiology. 2021 Oct; 41(7):1441-1452. doi: 10.1007/s10571-020-00929-9. [PMID: 32725456]
  • Dhirendra Singh, Sumeet Gupta, Inderjeet Verma, Mohamed A Morsy, Anroop B Nair, Al-Shaimaa F Ahmed. Hidden pharmacological activities of valproic acid: A new insight. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Oct; 142(?):112021. doi: 10.1016/j.biopha.2021.112021. [PMID: 34463268]
  • Adaobi I Bisi-Onyemaechi, Ugo N Chikani, Ndubuisi A Uwaezuoke, Ann E Aronu, Ngozi C Ojinnaka. Serum folate levels in children on long-term anti-seizure medication in a Nigerian tertiary center-Implications for practice and public health. Science progress. 2021 Oct; 104(4):368504211057680. doi: 10.1177/00368504211057680. [PMID: 34816782]
  • Ben E Biesterveld, Ali Z Siddiqui, Rachel L O'Connell, Henriette Remmer, Aaron M Williams, Alizeh Shamshad, William M Smith, Michael T Kemp, Glenn K Wakam, Hasan B Alam. Valproic Acid Protects Against Acute Kidney Injury in Hemorrhage and Trauma. The Journal of surgical research. 2021 10; 266(?):222-229. doi: 10.1016/j.jss.2021.04.014. [PMID: 34023578]
  • Umar F Bhatti, Henriette Remmer, Aaron M Williams, Ben E Biesterveld, Rachel Russo, Glenn Wakam, Michael Kemp, Rebecca Tagett, Baoling Liu, Yongqing Li, Hasan B Alam. Assessment of the Cytoprotective Effects of High-Dose Valproic Acid Compared to a Clinically Used Lower Dose. The Journal of surgical research. 2021 10; 266(?):125-141. doi: 10.1016/j.jss.2021.03.025. [PMID: 33991999]
  • José Antonio Hernández-Ramos, José Manuel Caro-Telle, Miguel Ángel Bruni-Montero, Dolores Canales-Siguero, José Miguel Ferrari-Piquero. Interaction between valproic acid and meropenem or ertapenem in patients with epilepsy: clinical relevance and results from pharmaceutical intervention. Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria. 2021 09; 45(6):335-339. doi: NULL. [PMID: 34806574]
  • J J García-Peñas, A Gil Nagel-Rein, R Sánchez-Carpintero, V Villanueva-Haba. Cannabidiol for the treatment of Lennox-Gastaut syndrome and Dravet syndrome: experts' recommendations for its use in clinical practice in Spain. Revista de neurologia. 2021 09; 73(S01):S1-S8. doi: 10.33588/rn.73s01.2021250. [PMID: 34486101]
  • Masanori Saito, Takeya Takizawa, Hitoshi Miyaoka. Factors associated with blood carnitine levels in adult epilepsy patients with chronic valproic acid therapy. Epilepsy research. 2021 Sep; 175(?):106697. doi: 10.1016/j.eplepsyres.2021.106697. [PMID: 34175794]
  • Shakeel Ahmad, Muhammad Aamir, Sobia Irum Kirmani, Zujaja Hina Haroon, Muhammad Usman Munir, Usama Bin Khalid. Association of Therapeutic Dose of Valproic Acid and Plasma Glycine Levels in Epileptic Patients. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. 2021 Sep; 31(9):1020-1023. doi: 10.29271/jcpsp.2021.09.1020. [PMID: 34500514]
  • Edel M Hughes, Patricia Calcagno, Connie Sanchez, Karen Smith, John P Kelly, David P Finn, Michelle Roche. Mu-opioid receptor agonism differentially alters social behaviour and immediate early gene expression in male adolescent rats prenatally exposed to valproic acid versus controls. Brain research bulletin. 2021 09; 174(?):260-267. doi: 10.1016/j.brainresbull.2021.06.018. [PMID: 34197938]
  • Bertan B Bayrak, Sebahat Yilmaz, Neziha Hacihasanoglu Cakmak, Refiye Yanardag. The effects of edaravone, a free-radical scavenger in lung injury induced by valproic acid demonstrated via different biochemical parameters. Journal of biochemical and molecular toxicology. 2021 Sep; 35(9):e22847. doi: 10.1002/jbt.22847. [PMID: 34309930]