VALPROIC ACID (BioDeep_00000398035)

Main id: BioDeep_00000003427

Secondary id: BioDeep_00000398034

natural product


代谢物信息卡片


2-PROPYL-pentanoIC ACID

化学式: C8H16O2 (144.115)
中文名称: 丙戊酸
谱图信息: 最多检出来源 Homo sapiens(blood) 14.58%

分子结构信息

SMILES: CCCC(CCC)C(=O)O
InChI: InChI=1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)

描述信息

D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D018692 - Antimanic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
N - Nervous system > N03 - Antiepileptics > N03A - Antiepileptics > N03AG - Fatty acid derivatives
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
D018377 - Neurotransmitter Agents > D018682 - GABA Agents
D004791 - Enzyme Inhibitors
KEIO_ID V004

同义名列表

5 个代谢物同义名

VALPROIC ACID; 2-PROPYL-pentanoIC ACID; Valproate(2); Valproic acid; Valproic acid



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 ALB, ANG, BDNF, BGLAP, CA3, CYP3A4, GSK3B, HDAC9, POMC, PPARG, PRL, TP53
Peripheral membrane protein 1 CYP1B1
Endoplasmic reticulum membrane 3 CYP1B1, CYP3A4, UGT2B7
Nucleus 8 ALB, ANG, DNMT1, GSK3B, HDAC9, PPARG, PRL, TP53
cytosol 8 ALB, ANG, CA3, GSK3B, LEP, PPARG, PRKCQ, TP53
dendrite 3 BDNF, BGLAP, GSK3B
centrosome 3 ALB, GSK3B, TP53
nucleoplasm 7 DNMT1, GSK3B, HDAC9, PPARG, PRL, SCNN1G, TP53
RNA polymerase II transcription regulator complex 2 PPARG, PRL
Cell membrane 1 GSK3B
Multi-pass membrane protein 2 CACNA1I, SCNN1G
glutamatergic synapse 1 GSK3B
Golgi apparatus 1 ALB
Golgi membrane 1 INS
growth cone 1 ANG
neuronal cell body 1 ANG
postsynapse 1 GSK3B
synaptic vesicle 1 BDNF
Presynapse 1 GSK3B
plasma membrane 4 CACNA1I, GSK3B, PRKCQ, SCNN1G
Membrane 6 BDNF, CACNA1I, CYP1B1, CYP3A4, TP53, UGT2B7
apical plasma membrane 1 SCNN1G
axon 2 BDNF, GSK3B
extracellular exosome 2 ALB, SCNN1G
endoplasmic reticulum 2 ALB, TP53
extracellular space 8 ALB, ANG, BDNF, BGLAP, INS, LEP, POMC, PRL
perinuclear region of cytoplasm 2 BDNF, PPARG
mitochondrion 4 CYP1B1, DNMT1, GSK3B, TP53
protein-containing complex 2 ALB, TP53
intracellular membrane-bounded organelle 3 CYP1B1, CYP3A4, PPARG
Microsome membrane 2 CYP1B1, CYP3A4
pericentric heterochromatin 1 DNMT1
Secreted 8 ALB, ANG, BDNF, BGLAP, INS, LEP, POMC, PRL
extracellular region 8 ALB, ANG, BDNF, BGLAP, INS, LEP, POMC, PRL
Single-pass membrane protein 1 UGT2B7
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
anchoring junction 1 ALB
transcription regulator complex 2 HDAC9, TP53
centriolar satellite 1 PRKCQ
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
external side of plasma membrane 1 SCNN1G
actin cytoskeleton 1 ANG
perikaryon 1 BGLAP
beta-catenin destruction complex 1 GSK3B
nucleolus 2 ANG, TP53
Wnt signalosome 1 GSK3B
vesicle 1 BGLAP
Apical cell membrane 1 SCNN1G
Cytoplasm, cytoskeleton 1 TP53
basement membrane 1 ANG
Nucleus, PML body 1 TP53
PML body 1 TP53
secretory granule 1 POMC
receptor complex 1 PPARG
ciliary basal body 1 ALB
chromatin 3 PPARG, PRL, TP53
Chromosome 1 ANG
centriole 1 ALB
Nucleus, nucleolus 1 ANG
spindle pole 1 ALB
blood microparticle 1 ALB
site of double-strand break 1 TP53
endosome lumen 2 INS, PRL
female germ cell nucleus 1 DNMT1
sodium channel complex 1 SCNN1G
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
germ cell nucleus 1 TP53
replication fork 2 DNMT1, TP53
secretory granule lumen 2 INS, POMC
Golgi lumen 2 BGLAP, INS
endoplasmic reticulum lumen 4 ALB, BDNF, BGLAP, INS
histone methyltransferase complex 1 HDAC9
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
platelet alpha granule lumen 1 ALB
voltage-gated calcium channel complex 1 CACNA1I
histone deacetylase complex 1 HDAC9
endocytic vesicle 1 ANG
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
[Isoform 1]: Nucleus 1 TP53
angiogenin-PRI complex 1 ANG
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
ciliary transition fiber 1 ALB


文献列表

  • Heba Fikry, Lobna A Saleh, Faten A Mahmoud, Sara Abdel Gawad, Hadwa Ali Abd-Alkhalek. CoQ10 targeted hippocampal ferroptosis in a status epilepticus rat model. Cell and tissue research. 2024 Jun; 396(3):371-397. doi: 10.1007/s00441-024-03880-z. [PMID: 38499882]
  • Eda Cergel, Burcin Alev Tuzuner, Ismet Burcu Turkyilmaz, Sehkar Oktay, Umar Faruk Magaji, Ozlem Sacan, Refiye Yanardag, Aysen Yarat. Reversal of Valproate-Induced Major Salivary Gland Changes By Moringa Oleifera Extract in Rats. Chemistry & biodiversity. 2024 May; 21(5):e202301959. doi: 10.1002/cbdv.202301959. [PMID: 38469951]
  • Zhuo Chen, Feng-Feng Wu, Jing Li, Jia-Bao Dong, Hong-Yi He, Xiong-Feng Li, Qian Lu, Wen-Xuan Zhang, Chang-Ming Shao, Zhao-Nong Yao, Nong Lin, Zhao-Ming Ye, Jun-Tao Xu, Heng-Yuan Li. Investigating the synergy of Shikonin and Valproic acid in inducing apoptosis of osteosarcoma cells via ROS-mediated EGR1 expression. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Apr; 126(?):155459. doi: 10.1016/j.phymed.2024.155459. [PMID: 38417243]
  • Lianyu Zhou, Peiyan Jiang, Linyang Zhao, Xinghang Fei, Yexi Tang, Yi Luo, Hong Gong, Xiaqing Wang, Xin Li, Song Li, Chunqing Zhang, Hui Yang, Xiaotang Fan. Ligustilide inhibits Purkinje cell ferritinophagy via the ULK1/NCOA4 pathway to attenuate valproic acid-induced autistic features. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Apr; 126(?):155443. doi: 10.1016/j.phymed.2024.155443. [PMID: 38394737]
  • Claire Grosu, William Hatoum, Marianna Piras, Nermine Laaboub, Setareh Ranjbar, Franziska Gamma, Kerstin J Plessen, Armin von Gunten, Martin Preisig, Philippe Conus, Chin B Eap. Associations of Valproate Doses With Weight Gain in Adult Psychiatric Patients: A 1-Year Prospective Cohort Study. The Journal of clinical psychiatry. 2024 03; 85(2):. doi: 10.4088/jcp.23m15008. [PMID: 38535509]
  • Qian Zhang, Yongjie Wang, Jie Tao, Ruixue Xia, Yijie Zhang, Zhirui Liu, Jiwei Cheng. Sex-biased single-cell genetic landscape in mice with autism spectrum disorder. Journal of genetics and genomics = Yi chuan xue bao. 2024 Mar; 51(3):338-351. doi: 10.1016/j.jgg.2023.08.012. [PMID: 37703921]
  • Yibing Zhou, Ze Chen, Hui Zhou, Bin Niu, Jing Liu, Yinglun Li, Yuqiang Mi, Ping Li. ACT001 Alleviates chronic kidney injury induced by a high-fat diet in mice through the GPR43/AMPK pathway. Lipids in health and disease. 2023 Nov; 22(1):198. doi: 10.1186/s12944-023-01949-2. [PMID: 37978497]
  • Pei Chen, Yang Yang, Yumeng Guo, Jing Li, Guishan Wang, Haining Yuan. Pleural Effusion Associated With Divalproex Sodium: A Case Report and Literature Review. Journal of clinical psychopharmacology. 2023 Nov; 43(6):541-543. doi: 10.1097/jcp.0000000000001760. [PMID: 37930211]
  • Rayara Nogueira de Freitas, Lucas Guilherme Leite da Silva, Gabriela Alice Fiais, Douglas Sandrac de Biagi Ferreira, Allice Santos Cruz Veras, Giovana Rampazzo Teixeira, Sandra Helena Penha Oliveira, Rita Cássia Menegati Dornelles, Ana Cláudia de Melo Stevanato Nakamune, Walid D Fakhouri, Antonio Hernandes Chaves-Neto. Alterations in salivary biochemical composition and redox state disruption induced by the anticonvulsant valproic acid in male rat salivary glands. Archives of oral biology. 2023 Nov; 155(?):105805. doi: 10.1016/j.archoralbio.2023.105805. [PMID: 37741048]
  • Sai Teja Meka, Sree Lalitha Bojja, Gautam Kumar, Sumit Raosaheb Birangal, C Mallikarjuna Rao. Novel HDAC inhibitors provide neuroprotection in MPTP-induced Parkinson's disease model of rats. European journal of pharmacology. 2023 Sep; 959(?):176067. doi: 10.1016/j.ejphar.2023.176067. [PMID: 37751833]
  • David Jutrić, Domagoj Đikić, Almoš Boroš, Dyana Odeh, Romana Gračan, Anđelo Beletić, Irena Landeka Jurčević. Combined effects of valproate and naringin on kidney antioxidative markers and serum parameters of kidney function in C57BL6 mice. Arhiv za higijenu rada i toksikologiju. 2023 Sep; 74(3):218-223. doi: 10.2478/aiht-2023-74-3764. [PMID: 37791674]
  • Peiyan Jiang, Lianyu Zhou, Linyang Zhao, Xinghang Fei, Zhifei Wang, Tianyao Liu, Yexi Tang, Dabing Li, Hong Gong, Yi Luo, Song Li, Hui Yang, Huiling Liao, Xiaotang Fan. Puerarin attenuates valproate-induced features of ASD in male mice via regulating Slc7a11-dependent ferroptosis. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023 Jul; ?(?):. doi: 10.1038/s41386-023-01659-4. [PMID: 37491673]
  • Valentine Turpin, Maud Schaffhauser, Mathieu Thabault, Agnès Aubert, Corinne Joffre, Eric Balado, Jean-Emmanuel Longueville, Maureen Francheteau, Christophe Burucoa, Maxime Pichon, Sophie Layé, Mohamed Jaber. Mice prenatally exposed to valproic acid do not show autism-related disorders when fed with polyunsaturated fatty acid-enriched diets. Scientific reports. 2023 07; 13(1):11235. doi: 10.1038/s41598-023-38423-z. [PMID: 37433863]
  • Ashley L Muller, Luisa Diaz-Arias, Mackenzie C Cervenka, Tanya J W McDonald. The effect of anti-seizure medications on lipid values in adults with epilepsy. Epilepsy & behavior : E&B. 2023 Jul; 144(?):109260. doi: 10.1016/j.yebeh.2023.109260. [PMID: 37244221]
  • Hong-Li Guo, Wei-Jun Wang, Na Dong, Yue-Tao Zhao, Hao-Ran Dai, Ya-Hui Hu, Yuan-Yuan Zhang, Jie Wang, Jin-Chun Qiu, Xiao-Peng Lu, Feng Chen. Integrating metabolomics and lipidomics revealed a decrease in plasma fatty acids but an increase in triglycerides in children with drug-refractory epilepsy. Epilepsia open. 2023 06; 8(2):466-478. doi: 10.1002/epi4.12712. [PMID: 36808532]
  • Sweety Mehra, Aitizaz Ul Ahsan, Madhu Sharma, Muskan Budhwar, Mani Chopra. Neuroprotective Efficacy of Fisetin Against VPA-Induced Autistic Neurobehavioral Alterations by Targeting Dysregulated Redox Homeostasis. Journal of molecular neuroscience : MN. 2023 Jun; ?(?):. doi: 10.1007/s12031-023-02127-w. [PMID: 37261645]
  • Mehmet Alper Arslan, Özgür Korhan Tunçel, Birşen Bilgici, Arzu Karaustaoğlu, Taner İlker Gümrükçüoğlu. Increased levels of lipid and protein oxidation in rat prefrontal cortex after treatment by lithium, valproic acid, and olanzapine. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Apr; ?(?):. doi: 10.1007/s00210-023-02494-6. [PMID: 37093250]
  • Q U Dongxiao, G E Yiqin, Zhuo Limin, Chen Liji, Xue Yonghua, Cheng Jiwei, Tao Jie, L I Guoyi, Zhu Yudan, Xiao Qian. Efficacy and mechanisms of Dingxian pill combined with valproic acid on pentylenetetrazol-induced chronic epilepsy in rats. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2023 Apr; 43(2):286-294. doi: 10.19852/j.cnki.jtcm.20220928.002. [PMID: 36994516]
  • Sara Haratizadeh, Mehdi Ranjbar, Mohsen Basiri, Masoumeh Nozari. Astrocyte responses to postnatal erythropoietin and nano-erythropoietin treatments in a valproic acid-induced animal model of autism. Journal of chemical neuroanatomy. 2023 Mar; 130(?):102257. doi: 10.1016/j.jchemneu.2023.102257. [PMID: 36918074]
  • Nan Zhang, Shu-Ting Wang, Lei Yao. Inhalation of Cananga odorata essential oil relieves anxiety behaviors in autism-like rats via regulation of serotonin and dopamine metabolism. Journal of integrative medicine. 2023 03; 21(2):205-214. doi: 10.1016/j.joim.2023.01.006. [PMID: 36792414]
  • Arief Hidayatullah, Wira E Putra, Sustiprijatno Sustiprijatno, Muhaimin Rifa'i, Diana Widiastuti, Muhammad F Heikal, Galuh W Permatasari. Concatenation of molecular docking and dynamics simulation of human papillomavirus type 16 E7 oncoprotein targeted ligands: In quest of cervical cancer's treatment. Anais da Academia Brasileira de Ciencias. 2023; 95(suppl 1):e20220633. doi: 10.1590/0001-3765202320220633. [PMID: 37466536]
  • Wenfang Song, Xinrui Yan, Yu Zhai, Jing Ren, Ting Wu, Han Guo, Yu Song, Xiaojiao Li, Yingjie Guo. Probiotics attenuate valproate-induced liver steatosis and oxidative stress in mice. PloS one. 2023; 18(11):e0294363. doi: 10.1371/journal.pone.0294363. [PMID: 37971986]
  • Ling Yang, Tung-Hu Tsai. Neuroprotective effect and herbal-drug pharmacokinetic interaction of Gastrodia elata extract on valproic acid. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Dec; 156(?):113938. doi: 10.1016/j.biopha.2022.113938. [PMID: 36411625]
  • Asmaa A Mahmoud, Hesham M Aboelghar, Sabry Moawad Abdelmageed, Heba M Abdallah, Mohamed I Garib, Nahla M S Abd El Hady. Assessment of asymmetric dimethylarginine and homocysteine in epileptic children receiving antiepileptic drugs. Pediatric research. 2022 12; 92(6):1606-1612. doi: 10.1038/s41390-022-02132-6. [PMID: 35688962]
  • Shuguang Du, Xuanyu Wang, Ye Hu, Shuxian Zhang, Dan Wang, Qinggao Zhang, Shuangping Liu. Valproic acid regulates MIEF1 through MST2-HIPPO to suppress breast cancer growth. Life sciences. 2022 Nov; 309(?):120976. doi: 10.1016/j.lfs.2022.120976. [PMID: 36126724]
  • Onur Ertik, Umar Faruk Magaji, Ozlem Sacan, Refiye Yanardag. Effect of Moringa oleifera leaf extract on valproate-induced oxidative damage in muscle. Drug and chemical toxicology. 2022 Nov; ?(?):1-11. doi: 10.1080/01480545.2022.2144876. [PMID: 36373188]
  • Wenliang Feng, Xuebin Jiang, Rujiang Zhang, Zhendong Guo, Daiquan Gao. Diagnosis of an Acinetobacter pittii from a patient in China with a multiplex PCR-based targeted gene sequencing platform of the cerebrospinal fluid: A case report with literature review. Medicine. 2022 Oct; 101(42):e31130. doi: 10.1097/md.0000000000031130. [PMID: 36281177]
  • Hong-Li Guo, Na Dong, Feng Chen, Yuan-Yuan Zeng, Ya-Hui Hu, Ying Xia, Man Tian, Xiao-Peng Lu, Jin-Chun Qiu. Effect of long-term valproic acid therapy on lipid profiles in paediatric patients with epilepsy: a meta-analysis. Epileptic disorders : international epilepsy journal with videotape. 2022 10; 24(5):1-9. doi: 10.1684/epd.2022.1460. [PMID: 35816100]
  • T Cantelmi, E Lepore, V R Unfer, V Unfer. Safety of inositol supplementation in patients taking lithium or valproic acid: a pilot clinical study. European review for medical and pharmacological sciences. 2022 10; 26(19):7269-7276. doi: 10.26355/eurrev_202210_29920. [PMID: 36263538]
  • Antoine Kavaye Kandeda, Saleh Nodeina, Symphorien Talom Mabou. An aqueous extract of Syzygium cumini protects against kainate-induced status epilepticus and amnesia: evidence for antioxidant and anti-inflammatory intervention. Metabolic brain disease. 2022 10; 37(7):2581-2602. doi: 10.1007/s11011-022-01052-y. [PMID: 35916986]
  • Devaraj Ezhilarasan, Uthirappan Mani. Valproic acid induced liver injury: An insight into molecular toxicological mechanism. Environmental toxicology and pharmacology. 2022 Oct; 95(?):103967. doi: 10.1016/j.etap.2022.103967. [PMID: 36058508]
  • Xiang Zou, Zilu Zhu, Yu Guo, Hongmiao Zhang, Yuchen Liu, Zhengyu Cui, Zunji Ke, Shize Jiang, Yusheng Tong, Zehan Wu, Ying Mao, Liang Chen, Deheng Wang. Neural excitatory rebound induced by valproic acid may predict its inadequate control of seizures. EBioMedicine. 2022 Sep; 83(?):104218. doi: 10.1016/j.ebiom.2022.104218. [PMID: 35970021]
  • Hanbin Chen, Shirley Weng In Siu, Clarence Tsun Ting Wong, Jianwen Qiu, Alex Kwok-Kuen Cheung, Simon Ming Yuen Lee. Anti-epileptic Kunitz-like peptides discovered in the branching coral Acropora digitifera through transcriptomic analysis. Archives of toxicology. 2022 09; 96(9):2589-2608. doi: 10.1007/s00204-022-03311-4. [PMID: 35604417]
  • Miyuki Takahashi, Toshiyuki Takasugi, Arisa Kawakami, Ran Wei, Kanae Ando, Toshio Ohshima, Shin-Ichi Hisanaga. Valproic Acid-Induced Anxiety and Depression Behaviors are Ameliorated in p39 Cdk5 Activator-Deficient Mice. Neurochemical research. 2022 Sep; 47(9):2773-2779. doi: 10.1007/s11064-022-03642-9. [PMID: 35674931]
  • Mishra Abhishek, Singla Rubal, Kumar Rohit, Joshi Rupa, Sarma Phulen, Kaur Gurjeet, Sharma Amit Raj, Prajapat Manisha, Bhatia Alka, Pallola Ramprasad, Medhi Bikash. Neuroprotective effect of the standardised extract of Bacopa monnieri (BacoMind) in valproic acid model of autism spectrum disorder in rats. Journal of ethnopharmacology. 2022 Jul; 293(?):115199. doi: 10.1016/j.jep.2022.115199. [PMID: 35346813]
  • Livia J De Picker, Marion Leboyer, John R Geddes, Manuel Morrens, Paul J Harrison, Maxime Taquet. Association between serum lithium level and incidence of COVID-19 infection. The British journal of psychiatry : the journal of mental science. 2022 07; 221(1):425-427. doi: 10.1192/bjp.2022.42. [PMID: 35318909]
  • Yiqian Chen, Jingzhen Chen, Xiaorong Zhuang, Xingyu Chen, Jianqi Zeng, Ru Wang, Jiayin Miao. Risk factors of elevated blood ammonia level in epilepsy patients treated with lamotrigine. Medicine. 2022 Jul; 101(26):e29780. doi: 10.1097/md.0000000000029780. [PMID: 35776999]
  • Fatih Mehmet Kandemir, Mustafa Ileriturk, Cihan Gur. Rutin protects rat liver and kidney from sodium valproate-induce damage by attenuating oxidative stress, ER stress, inflammation, apoptosis and autophagy. Molecular biology reports. 2022 Jul; 49(7):6063-6074. doi: 10.1007/s11033-022-07395-0. [PMID: 35352204]
  • Cangsang Song, Xingde Li, Panpan Mao, Wenbing Song, Lu Liu, Yang Zhang. Impact of CYP2C19 and CYP2C9 gene polymorphisms on sodium valproate plasma concentration in patients with epilepsy. European journal of hospital pharmacy : science and practice. 2022 07; 29(4):198-201. doi: 10.1136/ejhpharm-2020-002367. [PMID: 32868386]
  • Hiie Soeorg, Eva Sverrisdóttir, Morten Andersen, Trine Meldgaard Lund, Maurizio Sessa. Artificial Neural Network vs. Pharmacometric Model for Population Prediction of Plasma Concentration in Real-World Data: A Case Study on Valproic Acid. Clinical pharmacology and therapeutics. 2022 06; 111(6):1278-1285. doi: 10.1002/cpt.2577. [PMID: 35263452]
  • Muhammad Omer Iqbal, Majid Manzoor, Asma Mumtaz, Romana Riaz, Shafia Arshad, Imran Ahmad Khan, Usman Javaid, Zahid Manzoor, Shaukat Hussain Munawar, Shumaila Andleeb, Muhammad Masood Ahmed, Aqsa Aslam. Evaluation of the hepatoprotective activity of hydroalcoholic extract of Alhagi camelorum against valproic acid-induced hepatotoxicity in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jun; 150(?):112953. doi: 10.1016/j.biopha.2022.112953. [PMID: 35430391]
  • Z Shnewer Mahdi Al-Turfi, S M J Al-Hadrawy, J Abadi Mohammed, B Chasib Jabal. Evaluation of the Effect of Alcoholic Extract of Laurus Nobilis Leaves on Blood Biochemical Parameters and Histological Changes in the Liver and Kidney among Female Wistar Rats Treated with Depakene (Sodium Valproate). Archives of Razi Institute. 2022 06; 77(3):981-989. doi: 10.22092/ari.2022.357272.2011. [PMID: 36618289]
  • Yang Xu, Yameng Wang, Lulu Wang, Wenxing Liang, Qianqian Yang. Sodium Valproate Is Effective Against Botrytis cinerea Infection of Tomato by Enhancing Histone H3 Acetylation-Directed Gene Transcription and Triggering Tomato Fruit Immune Response. Phytopathology. 2022 Jun; 112(6):1264-1272. doi: 10.1094/phyto-11-21-0483-r. [PMID: 34982575]
  • Tomohito Mizuno, Riku Takahashi, Takahiro Kamiyama, Atsushi Suzuki, Masashi Suzuki. Neuroleptic Malignant Syndrome with Adrenal Insufficiency After BNT162b2 COVID-19 Vaccination in a Man Taking Valproate: A Case Report. The American journal of case reports. 2022 May; 23(?):e936217. doi: 10.12659/ajcr.936217. [PMID: 35514081]
  • Katlyn Nemani, Sharifa Z Williams, Mark Olfson, Emily Leckman-Westin, Molly Finnerty, Jammie Kammer, Thomas E Smith, Daniel J Silverman, Jean-Pierre Lindenmayer, Gillian Capichioni, James Clelland, Donald C Goff. Association Between the Use of Psychotropic Medications and the Risk of COVID-19 Infection Among Long-term Inpatients With Serious Mental Illness in a New York State-wide Psychiatric Hospital System. JAMA network open. 2022 05; 5(5):e2210743. doi: 10.1001/jamanetworkopen.2022.10743. [PMID: 35522282]
  • McKenzie R Young, Elizabeth K Bisaccia, Lubov Romantseva, Sara W Hovey. Valproic Acid Serum Concentration and Incidence of Toxicity in Pediatric Patients. Journal of child neurology. 2022 May; 37(6):461-470. doi: 10.1177/08830738221083480. [PMID: 35253521]
  • Gustavo D Mendes, Claudiney Cheli Lotufo, Renan Arthur Bosio-Guimarães, Heleson Alves de Castro, Tainah Babadopulos, André Ricardo Ribas Freitas, Natalícia de Jesus Antunes, Gilberto De Nucci. Comparative bioavailability study with two sodium valproate tablet formulations administered under fasting conditions in healthy subjects. International journal of clinical pharmacology and therapeutics. 2022 May; 60(5):232-241. doi: 10.5414/cp203961. [PMID: 35343430]
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