pyrimethamine (BioDeep_00000397930)
Main id: BioDeep_00000002347
natural product
代谢物信息卡片
pyrimethamine
化学式: C12H13ClN4 (248.0828688)
中文名称: 乙胺嘧啶
谱图信息:
最多检出来源 Homo sapiens(natural_products) 12.5%
分子结构信息
SMILES: CCc(n2)c(c(N)nc(N)2)c(c1)ccc(Cl)c1
InChI: InChI=1S/C12H13ClN4/c1-2-9-10(11(14)17-12(15)16-9)7-3-5-8(13)6-4-7/h3-6H,2H2,1H3,(H4,14,15,16,17)
描述信息
P - Antiparasitic products, insecticides and repellents > P01 - Antiprotozoals > P01B - Antimalarials > P01BD - Diaminopyrimidines
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent
C471 - Enzyme Inhibitor > C2153 - Dihydrofolate Reductase Inhibitor
D004791 - Enzyme Inhibitors > D005493 - Folic Acid Antagonists
[Raw Data] CB119_Pyrimethamine_pos_50eV_CB000043.txt
[Raw Data] CB119_Pyrimethamine_pos_40eV_CB000043.txt
[Raw Data] CB119_Pyrimethamine_pos_30eV_CB000043.txt
[Raw Data] CB119_Pyrimethamine_pos_20eV_CB000043.txt
[Raw Data] CB119_Pyrimethamine_pos_10eV_CB000043.txt
同义名列表
1 个代谢物同义名
数据库引用编号
24 个数据库交叉引用编号
- ChEBI: CHEBI:8673
- KEGG: C07391
- KEGGdrug: D00488
- PubChem: 4993
- PubChem: 7847554
- DrugBank: DB00205
- ChEMBL: CHEMBL36
- MeSH: Pyrimethamine
- CAS: 58-14-0
- MoNA: WA002453
- MoNA: WA002452
- MoNA: WA002451
- MoNA: WA002450
- MoNA: WA002449
- MoNA: CCMSLIB00000078386
- MoNA: FIO00291
- MoNA: FIO00290
- MoNA: FIO00289
- MoNA: FIO00288
- MoNA: FIO00287
- PubChem: 9595
- PDB-CCD: CP6
- NIKKAJI: J4.589F
- RefMet: Pyrimethamine
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Samuel Cota Teixeira, Marina Paschoalino, Guilherme de Souza, Alessandra Monteiro Rosini, Joed Pires de Lima Junior, Luana Carvalho Luz, Aryani Felixa Fajardo Martínez, Rosiane Nascimento Alves, Marcos Paulo Oliveira Almeida, Jaqueline Lopes Damasceno, Marcelo José Barbosa Silva, Francesca Ietta, Bellisa Freitas Barbosa, Eloisa Amália Vieira Ferro, Carlos Henrique Gomes Martins. Rottlerin impairs early and late steps of Toxoplasma gondii infection in human trophoblast cells and villous explants.
Chemico-biological interactions.
2023 Sep; ?(?):110716. doi:
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Acta parasitologica.
2023 Jun; ?(?):. doi:
10.1007/s11686-023-00689-8. [PMID: 37330943] - Chen Zhang, Kah Yean Lum, Aya C Taki, Robin B Gasser, Joseph J Byrne, Luis J Montaner, Ian Tietjen, Vicky M Avery, Rohan A Davis. Using a Bioactive Eremophila-Derived Serrulatane Scaffold to Generate a Unique Carbamate Library for Anti-infective Evaluations.
Journal of natural products.
2023 03; 86(3):557-565. doi:
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Clinical pharmacology in drug development.
2022 01; 11(1):123-128. doi:
10.1002/cpdd.988. [PMID: 34145987] - Barrios Leda Castaño, Andrea Alice Silva, Lina L Hernandez-Velasco, Ana Paula Da Silva Pinheiro, Daniel Gibaldi, José Roberto Mineo, Neide Maria Silva, Joseli Lannes-Vieira. Sulfadiazine Plus Pyrimethamine Therapy Reversed Multiple Behavioral and Neurocognitive Changes in Long-Term Chronic Toxoplasmosis by Reducing Brain Cyst Load and Inflammation-Related Alterations.
Frontiers in immunology.
2022; 13(?):822567. doi:
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Journal of chromatographic science.
2021 Oct; 59(10):923-927. doi:
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Ophthalmology.
2021 09; 128(9):1346-1355. doi:
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Cell reports.
2021 04; 35(4):109040. doi:
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Clinical pharmacology and therapeutics.
2021 02; 109(2):507-516. doi:
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Analytical chemistry.
2020 04; 92(8):5921-5928. doi:
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PloS one.
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2020; 10(?):600112. doi:
10.3389/fcimb.2020.600112. [PMID: 33324580] - Ngwene Hycentha Diengou, Samuel Nambile Cumber, Claude Ngwayu Nkfusai, Mbuh Salioh Mbinyui, Vecheusi Zennobia Viyoff, Fala Bede, Lilian Akwah, Joyce Mahlako Tsoka-Gwegweni, Anchang-Kimbi Judith. Factors associated with the uptake of intermittent preventive treatment of malaria in pregnancy in the Bamenda health districts, Cameroon.
The Pan African medical journal.
2020; 35(?):42. doi:
10.11604/pamj.2020.35.42.17600. [PMID: 32499857] - Isabella Quakyi, Bernard Tornyigah, Pascal Houze, Kwadwo A Kusi, Nathaniel Coleman, Guillaume Escriou, Amos Laar, Michel Cot, Julius Fobil, Gloria Quansah Asare, Philippe Deloron, Abraham K Anang, Gilles Cottrell, Michael F Ofori, Nicaise Tuikue Ndam. High uptake of Intermittent Preventive Treatment of malaria in pregnancy is associated with improved birth weight among pregnant women in Ghana.
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Molecular pharmacology.
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Scientific reports.
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Experimental parasitology.
2019 May; 200(?):7-12. doi:
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Journal of natural products.
2019 04; 82(4):1019-1023. doi:
10.1021/acs.jnatprod.8b00956. [PMID: 30865443] - Holger W Unger, Annjaleen P Hansa, Christelle Buffet, Wina Hasang, Andrew Teo, Louise Randall, Maria Ome-Kaius, Stephan Karl, Ayen A Anuan, James G Beeson, Ivo Mueller, Sarah J Stock, Stephen J Rogerson. Sulphadoxine-pyrimethamine plus azithromycin may improve birth outcomes through impacts on inflammation and placental angiogenesis independent of malarial infection.
Scientific reports.
2019 02; 9(1):2260. doi:
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Journal of medicinal chemistry.
2019 02; 62(3):1562-1576. doi:
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PloS one.
2019; 14(1):e0210692. doi:
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2018 Jan; 39(1):47-58. doi:
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2017 12; 80(12):3211-3217. doi:
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CPT: pharmacometrics & systems pharmacology.
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Antimicrobial agents and chemotherapy.
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Scientific reports.
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2017 01; 80(1):114-125. doi:
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Bioorganic & medicinal chemistry.
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2017; 100(1-2):31-39. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2016 10; 44(10):1562-8. doi:
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