Doxycycline (BioDeep_00000397892)

Volatile Flavor Compounds

代谢物信息卡片

Doxycycline

化学式: C22H24N2O8 (444.15325839999997)
中文名称: 强力霉素
谱图信息: 最多检出来源 Homo sapiens(urine) 39.29%

分子结构信息

SMILES: CC1C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O
InChI: InChI=1S/C22H24N2O8/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29/h4-7,10,14-15,17,25-27,30,32H,1-3H3,(H2,23,31)

描述信息

Tetracycline in which the 5beta-hydrogen is replaced by a hydroxy group, while the 6alpha-hydroxy group is replaced by hydrogen. A semi-synthetic tetracycline antibiotic, it is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with chronic obstructive pulmonary disease (COPD), and adult periodontitis.
A - Alimentary tract and metabolism > A01 - Stomatological preparations > A01A - Stomatological preparations > A01AB - Antiinfectives and antiseptics for local oral treatment
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01A - Tetracyclines > J01AA - Tetracyclines
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C784 - Protein Synthesis Inhibitor > C1595 - Tetracycline Antibiotic
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
C254 - Anti-Infective Agent > C258 - Antibiotic
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3678

同义名列表

3 个代谢物同义名

Doxycycline; Doxycycline; Doxycycline

数据库引用编号

38 个数据库交叉引用编号

ChEBI: CHEBI:50845
KEGG: C06973
KEGGdrug: D07876
PubChem: 54671203
DrugBank: DB00254
ChEMBL: CHEMBL436921
ChEMBL: CHEMBL1433
LipidMAPS: LMPK07000001
MeSH: Doxycycline
CAS: 7164-70-7
CAS: 564-25-0
CAS: 24390-14-5
MoNA: EQ367859
MoNA: EQ367858
MoNA: EQ367857
MoNA: EQ367856
MoNA: EQ367855
MoNA: EQ367854
MoNA: EQ367853
MoNA: EQ367852
MoNA: EQ367851
MoNA: EQ367809
MoNA: EQ367808
MoNA: EQ367807
MoNA: EQ367806
MoNA: EQ367805
MoNA: EQ367804
MoNA: EQ367803
MoNA: EQ367802
MoNA: EQ367801
MetaboLights: MTBLC50845
PubChem: 9187
KNApSAcK: C00017127
PDB-CCD: DXT
3DMET: B02103
NIKKAJI: J6.511K
RefMet: Doxycycline
KNApSAcK: 50845

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Alex P Arp, Megan E Williamson, Mario Vasquez, Gladys Quintero, Aidamalia Vargas Lowman, Agustin Sagel, Maxwell J Scott. Doxycycline is a viable alternative to tetracycline for use in insect Tet-Off transgenic sexing systems, as assessed in the blowflies Cochliomyia hominivorax and Lucilia cuprina (Diptera: Calliphoridae). Journal of economic entomology. 2024 Apr; 117(2):650-659. doi: 10.1093/jee/toae023. [PMID: 38401129]
Qi Yao, Dongmei Lin, Yanyan Yang, Yuehong Zhuang. Combination of Doxycycline with Metronidazole Protects against Pyroptosis in Rats with Endometritis through the Modulation of TLR4/NF-κB Pathway. Discovery medicine. 2024 Jan; 36(180):140-149. doi: 10.24976/discov.med.202436180.13. [PMID: 38273754]
Yuval Ramot, Abraham Nyska, Meidan Dvir, Shlomo Nedvetzki, Sefi Rosenfeld, Noam Emanuel. Preclinical In-Vivo Safety and Toxicokinetics of D-PLEX100 in an Abdominal Surgery Incision Model in Juvenile Miniature Swine. International journal of toxicology. 2024 Jan; 43(1):19-26. doi: 10.1177/10915818231205222. [PMID: 37787596]
Nana Zheng, Yuanyuan Xie, Meng Zhou, Yuzhen Liu, Haoxiang Xu, Rong Zeng, Chunping Wan, Min Li. Utilizing the Photodynamic Properties of Curcumin to Disrupt Biofilms in Cutibacterium acnes: A Promising Approach for Treating Acne. Photodiagnosis and photodynamic therapy. 2023 Dec; ?(?):103928. doi: 10.1016/j.pdpdt.2023.103928. [PMID: 38070633]
Fredrick Gudda, Emmanuel Stephen Odinga, Lei Tang, Michael Gatheru Waigi, Jian Wang, Dyaaaldin Abdalmegeed, Yanzheng Gao. Tetracyclines uptake from irrigation water by vegetables: Accumulation and antimicrobial resistance risks. Environmental pollution (Barking, Essex : 1987). 2023 Dec; 338(?):122696. doi: 10.1016/j.envpol.2023.122696. [PMID: 37804902]
Nora Fayez, Mohamed Khaled Ibrahim, Hala Abdullah Farrag, Marwa Abd El Hameed Mohamed, Seham Yousef El Tablawy. Synergistic effect of doxycycline and aqueous extract of irradiated khella on structure of nanobacteria isolated from kidney stones: In vitro and in vivo studies. Cell biochemistry and function. 2023 Dec; 41(8):1275-1294. doi: 10.1002/cbf.3862. [PMID: 37795914]
Wojciech Baran, Ewa Adamek. Degradation of veterinary antibiotics by Fenton process: Products identification and toxicity assessment. Chemosphere. 2023 Nov; 341(?):139854. doi: 10.1016/j.chemosphere.2023.139854. [PMID: 37619745]
Wenxin Xu, Waqas Ahmed, Mohsin Mahmood, Weidong Li, Sajid Mehmood. Physiological and biochemical responses of soft coral Sarcophyton trocheliophorum to doxycycline hydrochloride exposure. Scientific reports. 2023 10; 13(1):17665. doi: 10.1038/s41598-023-44383-1. [PMID: 37848653]
Maria Paula Carrillo, Marina Sevilla, Marta Casado, Benjamin Piña, Edward Pastor López, Victor Matamoros, Maria Vila-Costa, Carlos Barata. Impact of the antibiotic doxycycline on the D. magna reproduction, associated microbiome and antibiotic resistance genes in treated wastewater conditions. Environmental pollution (Barking, Essex : 1987). 2023 Oct; 334(?):122188. doi: 10.1016/j.envpol.2023.122188. [PMID: 37442322]
M Travis Caton, Amanda Baker, Eric R Smith, Edgar Perez, Kafi Hemphill, Daniel L Cooke, Christopher F Dowd. Dual-agent percutaneous sclerotherapy technique for macrocystic lymphatic malformations. Journal of neurointerventional surgery. 2023 Sep; 15(9):931. doi: 10.1136/jnis-2022-019255. [PMID: 35977819]
Joongkyu Park, Coralie Berthoux, Erika Hoyos-Ramirez, Lili Shan, Megumi Morimoto-Tomita, Yixiang Wang, Pablo E Castillo, Susumu Tomita. Chemogenetic regulation of the TARP-lipid interaction mimics LTP and reversibly modifies behavior. Cell reports. 2023 08; 42(8):112826. doi: 10.1016/j.celrep.2023.112826. [PMID: 37471228]
Anandrao A Patil, William Klobasa, Dina Espinoza-Rivera, Oliver Baars, Marcé D Lorenzen, Maxwell J Scott. Development of transgenic corn planthopper Peregrinus maidis that express the tetracycline transactivator. Insect molecular biology. 2023 08; 32(4):363-375. doi: 10.1111/imb.12836. [PMID: 36825366]
Haomiao Yu, Lei Zhang, Ruiwu Yang, Yuanyuan Jiang, Jinqiu Liao, Songyue Chai, Xuexue Deng, Long Wang, Xiang Pu, Yunsong Zhang, Songlin Zhang, Qingmiao Li, Li Zhang. Integrated Multiomics and Synergistic Functional Network Revealed the Mechanism in the Tolerance of Different Ecotypes of Salvia miltiorrhiza Bge. to Doxycycline Pollution. Environmental science & technology. 2023 07; 57(26):9603-9614. doi: 10.1021/acs.est.3c02908. [PMID: 37342920]
Elizabeth Holton, Carla Louw, Edward Archer, Tobias Louw, Gideon Wolfaardt, Barbara Kasprzyk-Hordern. Quantifying community-wide antibiotic usage via urban water fingerprinting: Focus on contrasting resource settings in South Africa. Water research. 2023 May; 240(?):120110. doi: 10.1016/j.watres.2023.120110. [PMID: 37247434]
Yuhang Wang, Junfeng Su, Ziyan Zhou, Jie Yang, Wenjuan Liu, Yafen Zhang, Pengyu Zhang, Tingting Guo, Guocai Li. Baicalein Resensitizes Multidrug-Resistant Gram-Negative Pathogens to Doxycycline. Microbiology spectrum. 2023 Apr; ?(?):e0470222. doi: 10.1128/spectrum.04702-22. [PMID: 37070985]
Chia Ying Lee, Chi-Ting Su, Tsuimin Tsai, Chien-Ming Hsieh, Kuan-Yu Hung, Jeng-Wen Huang, Chin-Tin Chen. Formulation Development of Doxycycline-Loaded Lipid Nanocarriers using Microfluidics by QbD Approach. Journal of pharmaceutical sciences. 2023 03; 112(3):740-750. doi: 10.1016/j.xphs.2022.09.023. [PMID: 36170906]
S Balasurya, Mohammad K Okla, Hamada AbdElgawad, Abdullah A Al-Ghamdi, Mostafa A Abdel-Maksoud, Saud S Al-Amri, Mahmoud M Y Madany, S Sudheer Khan. Sunlight promoted self-fenton photodegradation and pathway of doxycycline: Interactive effects of nanomaterial on bean plant and its genotoxicity against Allium cepa. Chemosphere. 2023 Feb; 313(?):137286. doi: 10.1016/j.chemosphere.2022.137286. [PMID: 36403816]
Yuyang Lei, Fangfang Li, Monika Mortimer, Zhi Li, Bi-Xia Peng, Minjie Li, Liang-Hong Guo, Guoqiang Zhuang. Antibiotics disrupt lipid metabolism in zebrafish (Danio rerio) larvae and 3T3-L1 preadipocytes. The Science of the total environment. 2023 Feb; 858(Pt 1):159755. doi: 10.1016/j.scitotenv.2022.159755. [PMID: 36349636]
Xueping Huang, Baihe Wu, Qiuzhao Chen, Yushan Chen, Xinhua Ji, Xiang Zhou, Biao Suo, Zhihui Lin, Xiaoling Zheng. Antibiotic resistance profile of Helicobacter pylori to 14 antibiotics: a multicenter study in Fujian, China. PeerJ. 2023; 11(?):e15611. doi: 10.7717/peerj.15611. [PMID: 37456872]
Feng-Yang Chen, Chang-An Geng, Chon-Kit Chou, Jing-Bin Zheng, Yang Yang, Yi-Fei Wang, Tian-Ze Li, Ping Li, Ji-Jun Chen, Xin Chen. Distepharinamide, a novel dimeric proaporphine alkaloid from Diploclisia glaucescens, inhibits the differentiation and proliferative expansion of CD4+Foxp3+ regulatory T cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Dec; 107(?):154482. doi: 10.1016/j.phymed.2022.154482. [PMID: 36202057]
Matheus Augusto Souza, Elda Gonçalves-Santos, Reggiani V Gonçalves, Eliziária C Santos, Camila C Campos, Marcos J Marques, Raquel L M Souza, Rômulo D Novaes. Doxycycline hyclate stimulates inducible nitric oxide synthase and arginase imbalance, potentiating inflammatory and oxidative lung damage in schistosomiasis. Biomedical journal. 2022 12; 45(6):857-869. doi: 10.1016/j.bj.2021.12.007. [PMID: 34971826]
M Swedha, Mohammad K Okla, Saud S Al-Amri, Ibrahim A Alaraidh, Abdullah A Al-Ghamdi, Asmaa Mohebaldin, Mostafa A Abdel-Maksoud, Mohammed Aufy, Christian R Studenik, Ajith M Thomas, Lija L Raju, S Sudheer Khan. Green synthesis of two-electron centre based ZnO/NiCo2S4 QDs-OVs using Punica granatum fruit peel extract for an exceptional visible light photocatalytic degradation of doxycycline and ciprofloxacin. Chemosphere. 2022 Oct; 304(?):135225. doi: 10.1016/j.chemosphere.2022.135225. [PMID: 35697102]
Nozomi Nishimura, Masaya Yokota, Shunjiro Kurihara, Arifumi Iwata, Takahiro Kageyama, Takashi Ito, Aiko Saku, Yuko Maezawa, Koichi Hirose, Hiroshi Nakajima. Airway epithelial STAT3 inhibits allergic inflammation via upregulation of stearoyl-CoA desaturase 1. Allergology international : official journal of the Japanese Society of Allergology. 2022 Oct; 71(4):520-527. doi: 10.1016/j.alit.2022.05.002. [PMID: 35660131]
Menglong Geng, Hui Gao, Baolin Wang, Kun Huang, Xiaoyan Wu, Chunmei Liang, Shuangqin Yan, Yan Han, Peng Ding, Wei Wang, Sheng Wang, Peng Zhu, Kaiyong Liu, Yunxia Cao, Fangbiao Tao. Urinary tetracycline antibiotics exposure during pregnancy and maternal thyroid hormone parameters: A repeated measures study. The Science of the total environment. 2022 Sep; 838(Pt 2):156146. doi: 10.1016/j.scitotenv.2022.156146. [PMID: 35605876]
Jia-Xin He, Hou-Qun Yuan, Yu-Fei Zhong, Xiong-Xin Peng, Yi-Fan Xia, Si-Yi Liu, Qing Fan, Jun-Lan Yang, Ke Deng, Xiao-Ying Wang, Guang-Ming Bao. A luminescent Eu3+-functionalized MOF for sensitive and rapid detection of tetracycline antibiotics in swine wastewater and pig kidney. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2022 Sep; 277(?):121252. doi: 10.1016/j.saa.2022.121252. [PMID: 35447556]
Sunday J Olusegun, Nelcy D S Mohallem, Virginia S T Ciminelli. Reducing the negative impact of ceftriaxone and doxycycline in aqueous solutions using ferrihydrite/plant-based composites: mechanism pathway. Environmental science and pollution research international. 2022 Sep; 29(44):66547-66561. doi: 10.1007/s11356-022-20561-y. [PMID: 35503153]
Kathryn R Hayden, Matthew Jones, Kyle R Elkin, Michael J Shreve, William Irvin Clees, Shirley Clark, Michael L Mashtare, Tamie L Veith, Herschel A Elliott, John E Watson, Justin Silverman, Thomas L Richard, Andrew F Read, Heather E Preisendanz. Impacts of the COVID-19 pandemic on pharmaceuticals in wastewater treated for beneficial reuse: Two case studies in central Pennsylvania. Journal of environmental quality. 2022 Sep; 51(5):1066-1082. doi: 10.1002/jeq2.20398. [PMID: 35919971]
Li Kong, Shuixin Yu, Lvfen Gu, Menglong Geng, Dongmei Zhang, Hongjuan Cao, Annuo Liu, Qunan Wang, Sufang Wang, Fangbiao Tao, Kaiyong Liu. Associations of typical antibiotic residues with elderly blood lipids and dyslipidemia in West Anhui, China. Ecotoxicology and environmental safety. 2022 Jul; 242(?):113889. doi: 10.1016/j.ecoenv.2022.113889. [PMID: 35853362]
Phuong Thi Thu Nguyen, Ha Viet Pham, Dung Hoang Van, Linh Van Pham, Hoi Thanh Nguyen, Hung Van Nguyen. Randomized controlled trial of the relative efficacy of high-dose intravenous ceftriaxone and oral cefixime combined with doxycycline for the treatment of Chlamydia trachomatis and Neisseria gonorrhoeae co-infection. BMC infectious diseases. 2022 Jul; 22(1):607. doi: 10.1186/s12879-022-07595-w. [PMID: 35810277]
Klaudia Stando, Ewa Korzeniewska, Ewa Felis, Monika Harnisz, Sylwia Bajkacz. Uptake of Pharmaceutical Pollutants and Their Metabolites from Soil Fertilized with Manure to Parsley Tissues. Molecules (Basel, Switzerland). 2022 Jul; 27(14):. doi: 10.3390/molecules27144378. [PMID: 35889250]
Wei Gao, Fuquan Fang, Tianna J Xia, Yan Zhang, Jiehao Sun, Qiaolin Wu, Weijian Wang. Doxycycline can reduce glycocalyx shedding by inhibiting matrix metalloproteinases in patients undergoing cardiopulmonary bypass: A randomized controlled trial. Microvascular research. 2022 07; 142(?):104381. doi: 10.1016/j.mvr.2022.104381. [PMID: 35588887]
Kenneth T Lewis, Lily R Oles, Ormond A MacDougald. Tetracycline response element driven Cre causes ectopic recombinase activity independent of transactivator element. Molecular metabolism. 2022 07; 61(?):101501. doi: 10.1016/j.molmet.2022.101501. [PMID: 35452876]
Breanna M Scorza, Kurayi G Mahachi, Arin D Cox, Angela J Toepp, Danielle Pessoa-Pereira, Phyllis Tyrrell, Jesse Buch, Jennifer A Foltz, Dean Lee, Christine A Petersen. Role of NK-Like CD8+ T Cells during Asymptomatic Borrelia burgdorferi Infection. Infection and immunity. 2022 05; 90(5):e0055521. doi: 10.1128/iai.00555-21. [PMID: 35416707]
Anna Dzimitrowicz, Magda Caban, Dominik Terefinko, Pawel Pohl, Piotr Jamroz, Weronika Babinska, Piotr Cyganowski, Piotr Stepnowski, Ewa Lojkowska, Wojciech Sledz, Agata Motyka-Pomagruk. Application of pulse-modulated radio-frequency atmospheric pressure glow discharge for degradation of doxycycline from a flowing liquid solution. Scientific reports. 2022 05; 12(1):7354. doi: 10.1038/s41598-022-11088-w. [PMID: 35513687]
Satish Kumar Sharma, Pankaj Bhatt, Syed Mohammed Basheeruddin Asdaq, Mohammed Kanan Alshammari, Abeer Alanazi, Naif Saleh Alrasheedi, Bader Abdullah Alrashdi, Saad Saleh Alyami, Bshayer Hamdan Alhazmi, Perwaiz Alam, Prerna Sharma, Ritu Tomar, Mandeep K Arora, Mohd Imran. Combined therapy with ivermectin and doxycycline can effectively alleviate the cytokine storm of COVID-19 infection amid vaccination drive: A narrative review. Journal of infection and public health. 2022 May; 15(5):566-572. doi: 10.1016/j.jiph.2022.03.014. [PMID: 35462191]
Yuan Gao, Zihe Zhang, Zhicai Lun, Liping Gong, Anran Xu, Xiuyun Li. Synergistic Effects of Fluconazole Combined with Doxycycline Against Dual-Species Cultures of Candida albicans and Staphylococcus epidermidis and the Mechanisms of Action. Microbial drug resistance (Larchmont, N.Y.). 2022 May; 28(5):525-535. doi: 10.1089/mdr.2021.0301. [PMID: 35363560]
Volodymyr Volodymyrovych Bezruk, Igor Dmytrovych Shkrobanets, Oleksii Serhiiovych Godovanets, Oleksandr Hryhorovych Buriak, Olga Ivanivna Pervozvanska, Ludmila Mykhailivna Honcharuk, Nina Ivanivna Voytkevich, Olena Victorivna Makarova, Oksana Ivanivna Yurkiv, Michael Ivanovych Sheremet, Mykhailo Mykhailovich Hresko, Mariya Ivanivna Velia, Svyatoslava Vasylivna Yurniuk, Maryna Dmytrivna Hresko, Tetiana Sergiivna Bulyk, Larysa Vasylyvna Rynzhuk. Management of antibacterial therapy of infectious and inflammatory diseases of the urinary tract in children and regional peculiarities during the COVID-19 pandemic. Journal of medicine and life. 2022 May; 15(5):617-619. doi: 10.25122/jml-2021-0293. [PMID: 35815078]
Preetha Shridas, Ailing Ji, Andrea C Trumbauer, Victoria P Noffsinger, Steve W Leung, Adam J Dugan, Sean E Thatcher, Lisa A Cassis, Frederick C de Beer, Nancy R Webb, Lisa R Tannock. Adipocyte-Derived Serum Amyloid A Promotes Angiotensin II-Induced Abdominal Aortic Aneurysms in Obese C57BL/6J Mice. Arteriosclerosis, thrombosis, and vascular biology. 2022 05; 42(5):632-643. doi: 10.1161/atvbaha.121.317225. [PMID: 35344382]
Manas Kumar Panigrahi, Hemanta Kumar Nayak, Subash Chandra Samal. A recent surge of doxycycline-induced pill esophagitis during the corona virus disease 2019 (COVID-19) pandemic. Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology. 2022 04; 41(2):206-207. doi: 10.1007/s12664-021-01224-1. [PMID: 34994946]
Lu Ding, Yatian Cao, Huihui Li, Fuxiang Wang, Dong-Yu Guo, Weiting Yang, Qinhe Pan. A ratiometric fluorescence-scattering sensor for rapid, sensitive and selective detection of doxycycline in animal foodstuffs. Food chemistry. 2022 Mar; 373(Pt B):131669. doi: 10.1016/j.foodchem.2021.131669. [PMID: 34863605]
Eugenia Sancho, Fabio Granados-Chinchilla, Elías Barquero-Calvo. Determination of streptomycin and doxycycline using LC/MS towards an effective treatment against an experimental Brucella abortus infection in mice. Journal of microbiological methods. 2022 03; 194(?):106436. doi: 10.1016/j.mimet.2022.106436. [PMID: 35219705]
Haralampos Milionis, Konstantinos Kostikas. Is it prime time to consider a clinical trial of doxycycline for the management of COVID-19?. Postgraduate medical journal. 2022 03; 98(e2):e107. doi: 10.1136/postgradmedj-2020-139358. [PMID: 35232857]
Yucong Fan, Weihua Yu, Yunwen Liao, Xiaohui Jiang, Zhonghua Wang, Zhengjun Cheng. Ratiometric detection of doxycycline in pharmaceutical based on dual ligands-enhanced copper nanoclusters. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2022 Feb; 267(Pt 1):120509. doi: 10.1016/j.saa.2021.120509. [PMID: 34688060]
Gurleenjot Kaur, Neetu Singh, Anita Rajor. Adsorptive decontamination of doxycycline hydrochloride via Prosopis juliflora activated carbon: Parameter optimization and disposal study. Water environment research : a research publication of the Water Environment Federation. 2022 Feb; 94(2):e10687. doi: 10.1002/wer.10687. [PMID: 35165966]
Scott Marston, Gudrun Mirick Mueller, Arick Sabin, Glen T Hansen, Bruce Lindgren, Conrado Aparicio, Alexandra R Armstrong, Ole H Larsen, Andrew Schmidt, Richard Kyle, Ramon Gustilo, Dean Tsukayama, Joan Bechtold, Mats Bue. Systemic versus free antibiotic delivery in preventing acute exogenous implant related infection in a rat model. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2022 02; 40(2):429-438. doi: 10.1002/jor.25052. [PMID: 33913540]
Karla E Merz, Jinhee Hwang, Chunxue Zhou, Rajakrishnan Veluthakal, Erika M McCown, Angelica Hamilton, Eunjin Oh, Wenting Dai, Patrick T Fueger, Lei Jiang, Janice M Huss, Debbie C Thurmond. Enrichment of the exocytosis protein STX4 in skeletal muscle remediates peripheral insulin resistance and alters mitochondrial dynamics via Drp1. Nature communications. 2022 01; 13(1):424. doi: 10.1038/s41467-022-28061-w. [PMID: 35058456]
Kai-Ni Shen, Wei-Jun Fu, Yu Wu, Yu-Jun Dong, Zhong-Xia Huang, Yong-Qiang Wei, Chun-Rui Li, Chun-Yan Sun, Ye Chen, Hui-Lei Miao, Yue-Lun Zhang, Xin-Xin Cao, Dao-Bin Zhou, Jian Li. Doxycycline Combined With Bortezomib-Cyclophosphamide-Dexamethasone Chemotherapy for Newly Diagnosed Cardiac Light-Chain Amyloidosis: A Multicenter Randomized Controlled Trial. Circulation. 2022 01; 145(1):8-17. doi: 10.1161/circulationaha.121.055953. [PMID: 34503349]
Selamawit Girma, Wondwossen Amogne. Investigating latent syphilis in HIV treatment-experienced Ethiopians and response to therapy. PloS one. 2022; 17(7):e0270878. doi: 10.1371/journal.pone.0270878. [PMID: 35819944]
Elisabete Ferreira, Zaida L Almeida, Pedro F Cruz, Marta Silva E Sousa, Paula Veríssimo, Rui M M Brito. Searching for the Best Transthyretin Aggregation Protocol to Study Amyloid Fibril Disruption. International journal of molecular sciences. 2021 Dec; 23(1):. doi: 10.3390/ijms23010391. [PMID: 35008816]
Linda My Huynh, Benjamin T Bonebrake, Dominick J DiMaio, Michael J Baine, Benjamin A Teply. Development of bullous pemphigoid following radiation therapy combined with nivolumab for renal cell carcinoma: A case report of abscopal toxicities. Medicine. 2021 Dec; 100(49):e28199. doi: 10.1097/md.0000000000028199. [PMID: 34889301]
Jon Brandon Mullholand, Nathanial Tolman, Anna De Obaldia, Eileen Hennrikus. Central nervous system involvement of anaplasmosis. BMJ case reports. 2021 Dec; 14(12):. doi: 10.1136/bcr-2021-243665. [PMID: 34880034]
Dolly Patel, Adeel Ahmad, Parth Maheshwari, Benjamin Bird, Adam Albert. Bacillus pumilus-Borne Food Poisoning in an Immunosuppressed Host. The American journal of medicine. 2021 12; 134(12):e573-e574. doi: 10.1016/j.amjmed.2021.06.025. [PMID: 34297978]
Jeong Min Cho, Jeonghyun Chang, Dong-Min Kim, Yee Gyung Kwak, Chong Rae Cho, Je Eun Song. Human granulocytic anaplasmosis combined with rhabdomyolysis: a case report. BMC infectious diseases. 2021 Nov; 21(1):1184. doi: 10.1186/s12879-021-06869-z. [PMID: 34823480]
Dyhia Amrane, Nicolas Primas, Christophe-Sébastien Arnold, Sébastien Hutter, Béatrice Louis, Julen Sanz-Serrano, Amaya Azqueta, Nadia Amanzougaghene, Shahin Tajeri, Dominique Mazier, Pierre Verhaeghe, Nadine Azas, Cyrille Botté, Patrice Vanelle. Antiplasmodial 2-thiophenoxy-3-trichloromethyl quinoxalines target the apicoplast of Plasmodium falciparum. European journal of medicinal chemistry. 2021 Nov; 224(?):113722. doi: 10.1016/j.ejmech.2021.113722. [PMID: 34364164]
Jesús A Mosquera-Sulbaran, Adriana Pedreañez, Yenddy Carrero, Diana Callejas. C-reactive protein as an effector molecule in Covid-19 pathogenesis. Reviews in medical virology. 2021 11; 31(6):e2221. doi: 10.1002/rmv.2221. [PMID: 34773448]
Juliana Montenegro Parente, Marcela Maria Blascke de Mello, Pedro Henrique Leite da Silva, Ana Carolina Mieko Omoto, Laena Pernomian, Isadora Sousa de Oliveira, Zabed Mahmud, Rubens Fazan, Eliane Candiani Arantes, Richard Schulz, Michele Mazzaron de Castro. MMP inhibition attenuates hypertensive eccentric cardiac hypertrophy and dysfunction by preserving troponin I and dystrophin. Biochemical pharmacology. 2021 11; 193(?):114744. doi: 10.1016/j.bcp.2021.114744. [PMID: 34453903]
Irene Sartini, Beata Łebkowska-Wieruszewska, Andrzej Lisowski, Amnart Poapolathep, Andrejs Sitovs, Mario Giorgi. Doxycycline pharmacokinetics in geese. Journal of veterinary pharmacology and therapeutics. 2021 Nov; 44(6):975-981. doi: 10.1111/jvp.13002. [PMID: 34318509]
Gwendolyn E Wood, Nicole L Jensen, Sabina Astete, Jørgen S Jensen, George E Kenny, Christine M Khosropour, Catherine W Gillespie, Lisa E Manhart, Patricia A Totten. Azithromycin and Doxycycline Resistance Profiles of U.S. Mycoplasma genitalium Strains and Their Association with Treatment Outcomes. Journal of clinical microbiology. 2021 10; 59(11):e0081921. doi: 10.1128/jcm.00819-21. [PMID: 34406799]
Bo Wang, Jinsong Ao, Xiaoyan Li, Weimin Yu, Dan Yu, Chengjun Qiu. Doxycycline sensitizes renal cell carcinoma to chemotherapy by preferentially inhibiting mitochondrial translation. The Journal of international medical research. 2021 Oct; 49(10):3000605211044368. doi: 10.1177/03000605211044368. [PMID: 34644207]
Javid Hosseini, Mohammadreza Pourani, Reihaneh Mehregan, Mohammad-Mehdi Forouzanfar, Reza M Robati. Frequency of COVID-19 in acne patients treated with oral doxycycline: A retrospective cross-sectional comparative study. Journal of cosmetic dermatology. 2021 Oct; 20(10):3062-3063. doi: 10.1111/jocd.14403. [PMID: 34416093]
George P Allen, Kristina M Deao, Stephanie A Hill, Sandra M Schipelliti, Thomas Tran. In vitro evaluation of antimicrobial resistance selection in Neisseria gonorrhoeae. International journal of antimicrobial agents. 2021 Oct; 58(4):106417. doi: 10.1016/j.ijantimicag.2021.106417. [PMID: 34391903]
Apu Chowdhury, Muhammad Sajid, Nabila Jahan, Temitope Isaac Adelusi, Pulak Maitra, Guolian Yin, Xudong Wu, Yuan Gao, Sicen Wang. A secondary approach with conventional medicines and supplements to recuperate current COVID-19 status. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Oct; 142(?):111956. doi: 10.1016/j.biopha.2021.111956. [PMID: 34332377]
Ejaz Shah, Calvin Abro, Fawwad Zaidi, Ruchika Goel. Doxycycline-induced acquired haemophilia A. BMJ case reports. 2021 Oct; 14(10):. doi: 10.1136/bcr-2021-244748. [PMID: 34598965]
Mingrong Qian, Jianmei Wang, Xiaofeng Ji, Hua Yang, Biao Tang, Hu Zhang, Guiling Yang, Zhiwei Bao, Yuanxiang Jin. Sub-chronic exposure to antibiotics doxycycline, oxytetracycline or florfenicol impacts gut barrier and induces gut microbiota dysbiosis in adult zebrafish (Daino rerio). Ecotoxicology and environmental safety. 2021 Sep; 221(?):112464. doi: 10.1016/j.ecoenv.2021.112464. [PMID: 34198189]
Rodrigo R R Duarte, Dennis C Copertino, Luis P Iñiguez, Jez L Marston, Yaron Bram, Yuling Han, Robert E Schwartz, Shuibing Chen, Douglas F Nixon, Timothy R Powell. Identifying FDA-approved drugs with multimodal properties against COVID-19 using a data-driven approach and a lung organoid model of SARS-CoV-2 entry. Molecular medicine (Cambridge, Mass.). 2021 09; 27(1):105. doi: 10.1186/s10020-021-00356-6. [PMID: 34503440]
Christopher C Butler, Ly-Mee Yu, Jienchi Dorward, Oghenekome Gbinigie, Gail Hayward, Benjamin R Saville, Oliver Van Hecke, Nicholas Berry, Michelle A Detry, Christina Saunders, Mark Fitzgerald, Victoria Harris, Ratko Djukanovic, Stephan Gadola, John Kirkpatrick, Simon de Lusignan, Emma Ogburn, Philip H Evans, Nicholas P B Thomas, Mahendra G Patel, F D Richard Hobbs. Doxycycline for community treatment of suspected COVID-19 in people at high risk of adverse outcomes in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial. The Lancet. Respiratory medicine. 2021 09; 9(9):1010-1020. doi: 10.1016/s2213-2600(21)00310-6. [PMID: 34329624]
Luisa Diomede, Sara Baroni, Ada De Luigi, Arianna Piotti, Jacopo Lucchetti, Claudia Fracasso, Luca Russo, Valerio Bonaldo, Nicolò Panini, Federica Filippini, Fabio Fiordaliso, Alessandro Corbelli, Marten Beeg, Massimo Pizzato, Francesca Caccuri, Marco Gobbi, Emiliano Biasini, Arnaldo Caruso, Mario Salmona. Doxycycline Inhibition of a Pseudotyped Virus Transduction Does Not Translate to Inhibition of SARS-CoV-2 Infectivity. Viruses. 2021 09; 13(9):. doi: 10.3390/v13091745. [PMID: 34578326]
Ronan J J Chapuis, Joe S Smith, Fabienne D Uehlinger, Melissa Meachem, Ron Johnson, Patricia M Dowling. Pharmacokinetics and pharmacodynamics of doxycycline in a Streptococcusequi subsp. zooepidemicus infection model in horses. Journal of veterinary pharmacology and therapeutics. 2021 Sep; 44(5):766-775. doi: 10.1111/jvp.12982. [PMID: 34057219]
Iñaki Robles-Vera, Néstor de la Visitación, Marta Toral, Manuel Sánchez, Miguel Romero, Manuel Gómez-Guzmán, Félix Vargas, Juan Duarte, Rosario Jiménez. Changes in Gut Microbiota Induced by Doxycycline Influence in Vascular Function and Development of Hypertension in DOCA-Salt Rats. Nutrients. 2021 Aug; 13(9):. doi: 10.3390/nu13092971. [PMID: 34578849]
Yasaman Shamshirgaran, Anna Jonebring, Anna Svensson, Isabelle Leefa, Mohammad Bohlooly-Y, Mike Firth, Kevin J Woollard, Alexis Hofherr, Ian M Rogers, Ryan Hicks. Rapid target validation in a Cas9-inducible hiPSC derived kidney model. Scientific reports. 2021 08; 11(1):16532. doi: 10.1038/s41598-021-95986-5. [PMID: 34400685]
Lu Ding, Yanyu Zhao, Huihui Li, Qiujuan Zhang, Weiting Yang, Bo Fu, Qinhe Pan. A highly selective ratiometric fluorescent probe for doxycycline based on the sensitization effect of bovine serum albumin. Journal of hazardous materials. 2021 08; 416(?):125759. doi: 10.1016/j.jhazmat.2021.125759. [PMID: 33831705]
Qing Hao Miow, Andres F Vallejo, Yu Wang, Jia Mei Hong, Chen Bai, Felicia Sw Teo, Alvin Dy Wang, Hong Rong Loh, Tuan Zea Tan, Ying Ding, Hoi Wah She, Suay Hong Gan, Nicholas I Paton, Josephine Lum, Alicia Tay, Cynthia Be Chee, Paul A Tambyah, Marta E Polak, Yee Tang Wang, Amit Singhal, Paul T Elkington, Jon S Friedland, Catherine Wm Ong. Doxycycline host-directed therapy in human pulmonary tuberculosis. The Journal of clinical investigation. 2021 08; 131(15):. doi: 10.1172/jci141895. [PMID: 34128838]
Lekshmi Narendrakumar, Iype Joseph, Sabu Thomas. Potential effectiveness and adverse implications of repurposing doxycycline in COVID-19 treatment. Expert review of anti-infective therapy. 2021 08; 19(8):1001-1008. doi: 10.1080/14787210.2021.1865803. [PMID: 33322952]
Timo Sorsa, Vaibhav Sahni, Nurcan Buduneli, Shipra Gupta, Ismo T Räisänen, Lorne M Golub, Hsi-Ming Lee, Tommi Pätilä, Nagihan Bostanci, Jukka Meurman, Pirjo Pärnänen, Solomon O Nwhator, Mohita Singla, Krishan Gauba. Active matrix metalloproteinase-8 (aMMP-8) point-of-care test (POCT) in the COVID-19 pandemic. Expert review of proteomics. 2021 08; 18(8):707-717. doi: 10.1080/14789450.2021.1976151. [PMID: 34468272]
Paula A Soeiro, Mayara A Romanelli, Marcelo O Cesar, Pâmella D Nogueira-Souza, Marcos Monteiro-Machado, Simone S C Oliveira, André L S Santos, Paulo A Melo, Lucienne S Lara. Doxycycline treatment reestablishes renal function of Wistar rats in experimental envenomation with Bothrops jararacussu venom. Toxicon : official journal of the International Society on Toxinology. 2021 Aug; 199(?):20-30. doi: 10.1016/j.toxicon.2021.05.008. [PMID: 34058237]
Marouf Alhalabi, Mohammed Waleed Alassi, Kamal Alaa Eddin, Khaled Cheha. Efficacy of two-week therapy with doxycycline-based quadruple regimen versus levofloxacin concomitant regimen for helicobacter pylori infection: a prospective single-center randomized controlled trial. BMC infectious diseases. 2021 Jul; 21(1):642. doi: 10.1186/s12879-021-06356-5. [PMID: 34218802]
Tom Y Zhao, Neelesh A Patankar. Tetracycline as an inhibitor to the SARS-CoV-2. Journal of cellular biochemistry. 2021 07; 122(7):752-759. doi: 10.1002/jcb.29909. [PMID: 33619758]
Nicolò Girometti, Muhammad H Junejo, Diarmuid Nugent, Alan McOwan, Gary Whitlock. Clinical and serological outcomes in patients treated with oral doxycycline for early neurosyphilis. The Journal of antimicrobial chemotherapy. 2021 06; 76(7):1916-1919. doi: 10.1093/jac/dkab100. [PMID: 33783506]
Hubert J Sijben, Wieke M van Oostveen, Peter B R Hartog, Laura Stucchi, Andrea Rossignoli, Giovanna Maresca, Lia Scarabottolo, Adriaan P IJzerman, Laura H Heitman. Label-free high-throughput screening assay for the identification of norepinephrine transporter (NET/SLC6A2) inhibitors. Scientific reports. 2021 06; 11(1):12290. doi: 10.1038/s41598-021-91700-7. [PMID: 34112854]
Yasemin Cag, Haluk Vahaboglu. A novel approach to managing COVID-19 patients: results of lopinavir plus doxycycline cohort-authors' reply. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2021 06; 40(6):1351-1352. doi: 10.1007/s10096-020-04099-w. [PMID: 33439342]
Keiji Kuroda, Satoru Takamizawa, Hiroshi Motoyama, Ryo Tsutsumi, Rie Sugiyama, Koji Nakagawa, Rikikazu Sugiyama, Yasushi Kuribayashi. Analysis of the therapeutic effects of hysteroscopic polypectomy with and without doxycycline treatment on chronic endometritis with endometrial polyps. American journal of reproductive immunology (New York, N.Y. : 1989). 2021 06; 85(6):e13392. doi: 10.1111/aji.13392. [PMID: 33501741]
Subhrojyoti Bhowmick, Amit Dang, B N Vallish, Sumit Dang. Safety and Efficacy of Ivermectin and Doxycycline Monotherapy and in Combination in the Treatment of COVID-19: A Scoping Review. Drug safety. 2021 06; 44(6):635-644. doi: 10.1007/s40264-021-01066-y. [PMID: 33864232]
Reaz Mahmud, Md Mujibur Rahman, Iftikher Alam, Kazi Gias Uddin Ahmed, A K M Humayon Kabir, S K Jakaria Been Sayeed, Mohammad Aftab Rassel, Farhana Binte Monayem, Md Shahidul Islam, Mohammad Monirul Islam, Anindita Das Barshan, Mohammad Mahfuzul Hoque, Md Uzzal Mallik, Mohammad Abdullah Yusuf, Mohammad Zaid Hossain. Ivermectin in combination with doxycycline for treating COVID-19 symptoms: a randomized trial. The Journal of international medical research. 2021 May; 49(5):3000605211013550. doi: 10.1177/03000605211013550. [PMID: 33983065]
Dan-Dan Zhang, Xin-Peng Duan, Yu Xiao, Peng Wu, Zhong-Xiuzi Gao, Wen-Hui Wang, Dao-Hong Lin. Deletion of renal Nedd4-2 abolishes the effect of high sodium intake (HS) on Kir4.1, ENaC, and NCC and causes hypokalemia during high HS. American journal of physiology. Renal physiology. 2021 05; 320(5):F883-F896. doi: 10.1152/ajprenal.00555.2020. [PMID: 33818128]
Sayonee Das, Sidhartha Chattopadhyay, Kausik Munsi, Sagar Basu. Scrub typhus with cerebral venous sinus thrombosis: a rare presentation. BMJ case reports. 2021 Apr; 14(4):. doi: 10.1136/bcr-2020-241401. [PMID: 33910803]
Elisa Kortela, Mari J Kanerva, Juha Puustinen, Saija Hurme, Laura Airas, Anneli Lauhio, Ulla Hohenthal, Päivi Jalava-Karvinen, Tuomas Nieminen, Taru Finnilä, Tony Häggblom, Annukka Pietikäinen, Mari Koivisto, Johanna Vilhonen, Minna Marttila-Vaara, Jukka Hytönen, Jarmo Oksi. Oral Doxycycline Compared to Intravenous Ceftriaxone in the Treatment of Lyme Neuroborreliosis: A Multicenter, Equivalence, Randomized, Open-label Trial. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2021 04; 72(8):1323-1331. doi: 10.1093/cid/ciaa217. [PMID: 32133487]
Yoshiaki Morishita, Aaron P Kellogg, Dennis Larkin, Wei Chen, Suryakiran Vadrevu, Leslie Satin, Ming Liu, Peter Arvan. Cell death-associated lipid droplet protein CIDE-A is a noncanonical marker of endoplasmic reticulum stress. JCI insight. 2021 04; 6(7):. doi: 10.1172/jci.insight.143980. [PMID: 33661766]
Parthasarathi Bhattacharyya, Brajesh Singh, Surita Sarkar, Soumen Kumar Das, Bodhisattwa Chakraborty, Dipanjan Saha, Kumar Chakraborty, Indranil Saha, Koel Chaudhury. Impact of long-term doxycycline on lung function & exacerbations: A real-world open, prospective pilot observation on chronic obstructive pulmonary disease. The Indian journal of medical research. 2021 Apr; 153(4):465-474. doi: 10.4103/ijmr.ijmr_1254_18. [PMID: 34380793]
Hayder M Al-Kuraishy, Ali I Al-Gareeb, Naeem Qusty, Natália Cruz-Martins, Gaber El-Saber Batiha. Sequential doxycycline and colchicine combination therapy in Covid-19: The salutary effects. Pulmonary pharmacology & therapeutics. 2021 04; 67(?):102008. doi: 10.1016/j.pupt.2021.102008. [PMID: 33727066]
Andrea Dean, Rathi Asaithambi, Hannah C Neubauer. Murine Typhus in 5 Children Hospitalized for Multisystem Inflammatory Syndrome in Children. Hospital pediatrics. 2021 Apr; 11(4):e61-e65. doi: 10.1542/hpeds.2020-005652. [PMID: 33431429]
Lian-Jie Hou, Mei-Ying Xie, Wen-Chu Ye, Guo-Jun Zhao. Doxycycline ameliorates autophagy by inhibiting p38 MAPK in cardiac myocytes. International journal of cardiology. 2021 04; 328(?):178. doi: 10.1016/j.ijcard.2020.12.038. [PMID: 33358829]
Mamadou A Baldé, Emmy Tuenter, Mohamed S Traoré, Laura Peeters, An Matheeussen, Paul Cos, Guy Caljon, Tom Vermeyen, Wouter Herrebout, Aliou M Balde, Kenn Foubert, Luc Pieters. Antiplasmodial Oleanane Triterpenoids from Terminalia albida Root Bark. Journal of natural products. 2021 03; 84(3):666-675. doi: 10.1021/acs.jnatprod.0c01119. [PMID: 33667089]
Masashi Ohe, Ken Furuya, Houman Goudarzi. Multidrug treatment for COVID-19. Drug discoveries & therapeutics. 2021 Mar; 15(1):39-41. doi: 10.5582/ddt.2021.01005. [PMID: 33612572]
Martina Montinari, Laura Atzori, Sefora Valdevit, Franco Rongioletti. Erythema annulare centrifugum with anosmia and ageusia in a SARS-CoV-2 exposed patient successfully treated with doxycycline. International journal of dermatology. 2021 Mar; 60(3):384-386. doi: 10.1111/ijd.15356. [PMID: 33368328]
Marta Jerez-Peña, Borja Salvador-Culla, María F de la Paz, Rafael I Barraquer. Bilateral Boston keratoprosthesis type 1 in a case of severe Mooren's ulcer. European journal of ophthalmology. 2021 Mar; 31(2):NP33-NP38. doi: 10.1177/1120672120909768. [PMID: 32141311]
Ziling Zeng, Chunjuan Wang, Cuicui Liu, Baojie Wang, Xin Meng, Yan Chen, Shougang Guo. Follow-up of a Rickettsia felis encephalitis: Some new insights into clinical and imaging features. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2021 Mar; 104(?):300-302. doi: 10.1016/j.ijid.2020.12.090. [PMID: 33444751]
Banu Cakir. A novel approach to managing COVID-19 patients; results of lopinavir plus doxycycline cohort. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2021 03; 40(3):663-664. doi: 10.1007/s10096-020-04112-2. [PMID: 33415491]
Evan S Morrison, Shenbagam Dewar. Case Report: Limitations of Virtual Care in Older Adults with Functional and Cognitive Impairment. American family physician. 2021 02; 103(4):201. doi: NULL. [PMID: 33587583]
Yasemin Cag, Sacit Icten, Burcu Isik-Goren, Naciye Betul Baysal, Begum Bektas, Ece Selvi, Pinar Ergen, Ozlem Aydin, Ayse Canan Ucisik, Fatma Yilmaz-Karadag, Hulya Caskurlu, Tulin Akarsu-Ayazoglu, Hasan Kocoglu, Sinan Uzman, Muge Nural-Pamukcu, Ferhat Arslan, Gurhan Bas, Mahmut Tayyar Kalcioglu, Haluk Vahaboglu. A novel approach to managing COVID-19 patients; results of lopinavir plus doxycycline cohort. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2021 Feb; 40(2):407-411. doi: 10.1007/s10096-020-04016-1. [PMID: 32856202]