Doxycycline (BioDeep_00000002205)

 

Secondary id: BioDeep_00000397892

human metabolite blood metabolite Chemicals and Drugs Volatile Flavor Compounds


代谢物信息卡片


(4S,4AR,5S,5ar,6R,12as)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide

化学式: C22H24N2O8 (444.15325839999997)
中文名称: 强力霉素
谱图信息: 最多检出来源 Homo sapiens(blood) 48.89%

分子结构信息

SMILES: c1cc(c2c(c1)[C@@H]([C@@H]1C(=C([C@]3([C@@H]([C@H]1O)[C@@H](C(=C(C3=O)C(=O)N)O)N(C)C)O)O)C2=O)C)O
InChI: InChI=1S/C22H24N2O8/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29/h4-7,10,14-15,17,25-27,30,32H,1-3H3,(H2,23,31)

描述信息

Doxycycline is only found in individuals that have used or taken this drug. It is a synthetic tetracycline derivative with similar antimicrobial activity. Animal studies suggest that it may cause less tooth staining than other tetracyclines. It is used in some areas for the treatment of chloroquine-resistant falciparum malaria (malaria, falciparum). [PubChem]Doxycycline, like minocycline, is lipophilic and can pass through the lipid bilayer of bacteria. Doxycycline reversibly binds to the 30 S ribosomal subunits and possibly the 50S ribosomal subunit(s), blocking the binding of aminoacyl tRNA to the mRNA and inhibiting bacterial protein synthesis. Doxycycline prevents the normal function of the apicoplast of Plasmodium falciparum, a malaria causing organism.
A - Alimentary tract and metabolism > A01 - Stomatological preparations > A01A - Stomatological preparations > A01AB - Antiinfectives and antiseptics for local oral treatment
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01A - Tetracyclines > J01AA - Tetracyclines
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C784 - Protein Synthesis Inhibitor > C1595 - Tetracycline Antibiotic
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
C254 - Anti-Infective Agent > C258 - Antibiotic
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

45 个代谢物同义名

(4S,4AR,5S,5ar,6R,12as)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide; 5-Hydroxy-alpha-6-deoxytetracycline; 5-Hydroxy-α-6-deoxytetracycline; 5-Hydroxy-a-6-deoxytetracycline; 6alpha-Deoxy-5-oxytetracycline; alpha-6-Deoxyoxytetracycline; 6a-Deoxy-5-oxytetracycline; 6Α-deoxy-5-oxytetracycline; Doxycycline monohydrate; Doxycycline (anhydrous); 6-Deoxyoxytetracycline; Doxcycline anhydrous; Doxycycline hyclate; alpha-Doxycycline; 4-Epidoxycycline; Doxytetracycline; Vibraveineuse; Doxycyclinum; Supracyclin; Doxiciclina; Deoxymykoin; Doxycycline; Vibramycine; Vibranos SF; Vibramycin; Vibravenos; Jenacyclin; Hydramycin; Medeomycin; Doxycyclin; Dentistar; Doxivetin; Doxychel; Tolexine; Liviatin; Pulmodox; Monodox; Doxycen; GS 3065; Doxinyl; Ronaxan; Unidox; DOXY; Doxycycline; Doxycycline



数据库引用编号

30 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Alex P Arp, Megan E Williamson, Mario Vasquez, Gladys Quintero, Aidamalia Vargas Lowman, Agustin Sagel, Maxwell J Scott. Doxycycline is a viable alternative to tetracycline for use in insect Tet-Off transgenic sexing systems, as assessed in the blowflies Cochliomyia hominivorax and Lucilia cuprina (Diptera: Calliphoridae). Journal of economic entomology. 2024 Apr; 117(2):650-659. doi: 10.1093/jee/toae023. [PMID: 38401129]
  • Qi Yao, Dongmei Lin, Yanyan Yang, Yuehong Zhuang. Combination of Doxycycline with Metronidazole Protects against Pyroptosis in Rats with Endometritis through the Modulation of TLR4/NF-κB Pathway. Discovery medicine. 2024 Jan; 36(180):140-149. doi: 10.24976/discov.med.202436180.13. [PMID: 38273754]
  • Yuval Ramot, Abraham Nyska, Meidan Dvir, Shlomo Nedvetzki, Sefi Rosenfeld, Noam Emanuel. Preclinical In-Vivo Safety and Toxicokinetics of D-PLEX100 in an Abdominal Surgery Incision Model in Juvenile Miniature Swine. International journal of toxicology. 2024 Jan; 43(1):19-26. doi: 10.1177/10915818231205222. [PMID: 37787596]
  • Nana Zheng, Yuanyuan Xie, Meng Zhou, Yuzhen Liu, Haoxiang Xu, Rong Zeng, Chunping Wan, Min Li. Utilizing the Photodynamic Properties of Curcumin to Disrupt Biofilms in Cutibacterium acnes: A Promising Approach for Treating Acne. Photodiagnosis and photodynamic therapy. 2023 Dec; ?(?):103928. doi: 10.1016/j.pdpdt.2023.103928. [PMID: 38070633]
  • Fredrick Gudda, Emmanuel Stephen Odinga, Lei Tang, Michael Gatheru Waigi, Jian Wang, Dyaaaldin Abdalmegeed, Yanzheng Gao. Tetracyclines uptake from irrigation water by vegetables: Accumulation and antimicrobial resistance risks. Environmental pollution (Barking, Essex : 1987). 2023 Dec; 338(?):122696. doi: 10.1016/j.envpol.2023.122696. [PMID: 37804902]
  • Nora Fayez, Mohamed Khaled Ibrahim, Hala Abdullah Farrag, Marwa Abd El Hameed Mohamed, Seham Yousef El Tablawy. Synergistic effect of doxycycline and aqueous extract of irradiated khella on structure of nanobacteria isolated from kidney stones: In vitro and in vivo studies. Cell biochemistry and function. 2023 Dec; 41(8):1275-1294. doi: 10.1002/cbf.3862. [PMID: 37795914]
  • Wojciech Baran, Ewa Adamek. Degradation of veterinary antibiotics by Fenton process: Products identification and toxicity assessment. Chemosphere. 2023 Nov; 341(?):139854. doi: 10.1016/j.chemosphere.2023.139854. [PMID: 37619745]
  • Wenxin Xu, Waqas Ahmed, Mohsin Mahmood, Weidong Li, Sajid Mehmood. Physiological and biochemical responses of soft coral Sarcophyton trocheliophorum to doxycycline hydrochloride exposure. Scientific reports. 2023 10; 13(1):17665. doi: 10.1038/s41598-023-44383-1. [PMID: 37848653]
  • Maria Paula Carrillo, Marina Sevilla, Marta Casado, Benjamin Piña, Edward Pastor López, Victor Matamoros, Maria Vila-Costa, Carlos Barata. Impact of the antibiotic doxycycline on the D. magna reproduction, associated microbiome and antibiotic resistance genes in treated wastewater conditions. Environmental pollution (Barking, Essex : 1987). 2023 Oct; 334(?):122188. doi: 10.1016/j.envpol.2023.122188. [PMID: 37442322]
  • M Travis Caton, Amanda Baker, Eric R Smith, Edgar Perez, Kafi Hemphill, Daniel L Cooke, Christopher F Dowd. Dual-agent percutaneous sclerotherapy technique for macrocystic lymphatic malformations. Journal of neurointerventional surgery. 2023 Sep; 15(9):931. doi: 10.1136/jnis-2022-019255. [PMID: 35977819]
  • Joongkyu Park, Coralie Berthoux, Erika Hoyos-Ramirez, Lili Shan, Megumi Morimoto-Tomita, Yixiang Wang, Pablo E Castillo, Susumu Tomita. Chemogenetic regulation of the TARP-lipid interaction mimics LTP and reversibly modifies behavior. Cell reports. 2023 08; 42(8):112826. doi: 10.1016/j.celrep.2023.112826. [PMID: 37471228]
  • Anandrao A Patil, William Klobasa, Dina Espinoza-Rivera, Oliver Baars, Marcé D Lorenzen, Maxwell J Scott. Development of transgenic corn planthopper Peregrinus maidis that express the tetracycline transactivator. Insect molecular biology. 2023 08; 32(4):363-375. doi: 10.1111/imb.12836. [PMID: 36825366]
  • Haomiao Yu, Lei Zhang, Ruiwu Yang, Yuanyuan Jiang, Jinqiu Liao, Songyue Chai, Xuexue Deng, Long Wang, Xiang Pu, Yunsong Zhang, Songlin Zhang, Qingmiao Li, Li Zhang. Integrated Multiomics and Synergistic Functional Network Revealed the Mechanism in the Tolerance of Different Ecotypes of Salvia miltiorrhiza Bge. to Doxycycline Pollution. Environmental science & technology. 2023 07; 57(26):9603-9614. doi: 10.1021/acs.est.3c02908. [PMID: 37342920]
  • Elizabeth Holton, Carla Louw, Edward Archer, Tobias Louw, Gideon Wolfaardt, Barbara Kasprzyk-Hordern. Quantifying community-wide antibiotic usage via urban water fingerprinting: Focus on contrasting resource settings in South Africa. Water research. 2023 May; 240(?):120110. doi: 10.1016/j.watres.2023.120110. [PMID: 37247434]
  • Yuhang Wang, Junfeng Su, Ziyan Zhou, Jie Yang, Wenjuan Liu, Yafen Zhang, Pengyu Zhang, Tingting Guo, Guocai Li. Baicalein Resensitizes Multidrug-Resistant Gram-Negative Pathogens to Doxycycline. Microbiology spectrum. 2023 Apr; ?(?):e0470222. doi: 10.1128/spectrum.04702-22. [PMID: 37070985]
  • Chia Ying Lee, Chi-Ting Su, Tsuimin Tsai, Chien-Ming Hsieh, Kuan-Yu Hung, Jeng-Wen Huang, Chin-Tin Chen. Formulation Development of Doxycycline-Loaded Lipid Nanocarriers using Microfluidics by QbD Approach. Journal of pharmaceutical sciences. 2023 03; 112(3):740-750. doi: 10.1016/j.xphs.2022.09.023. [PMID: 36170906]
  • S Balasurya, Mohammad K Okla, Hamada AbdElgawad, Abdullah A Al-Ghamdi, Mostafa A Abdel-Maksoud, Saud S Al-Amri, Mahmoud M Y Madany, S Sudheer Khan. Sunlight promoted self-fenton photodegradation and pathway of doxycycline: Interactive effects of nanomaterial on bean plant and its genotoxicity against Allium cepa. Chemosphere. 2023 Feb; 313(?):137286. doi: 10.1016/j.chemosphere.2022.137286. [PMID: 36403816]
  • Yuyang Lei, Fangfang Li, Monika Mortimer, Zhi Li, Bi-Xia Peng, Minjie Li, Liang-Hong Guo, Guoqiang Zhuang. Antibiotics disrupt lipid metabolism in zebrafish (Danio rerio) larvae and 3T3-L1 preadipocytes. The Science of the total environment. 2023 Feb; 858(Pt 1):159755. doi: 10.1016/j.scitotenv.2022.159755. [PMID: 36349636]
  • Xueping Huang, Baihe Wu, Qiuzhao Chen, Yushan Chen, Xinhua Ji, Xiang Zhou, Biao Suo, Zhihui Lin, Xiaoling Zheng. Antibiotic resistance profile of Helicobacter pylori to 14 antibiotics: a multicenter study in Fujian, China. PeerJ. 2023; 11(?):e15611. doi: 10.7717/peerj.15611. [PMID: 37456872]
  • Feng-Yang Chen, Chang-An Geng, Chon-Kit Chou, Jing-Bin Zheng, Yang Yang, Yi-Fei Wang, Tian-Ze Li, Ping Li, Ji-Jun Chen, Xin Chen. Distepharinamide, a novel dimeric proaporphine alkaloid from Diploclisia glaucescens, inhibits the differentiation and proliferative expansion of CD4+Foxp3+ regulatory T cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Dec; 107(?):154482. doi: 10.1016/j.phymed.2022.154482. [PMID: 36202057]
  • Matheus Augusto Souza, Elda Gonçalves-Santos, Reggiani V Gonçalves, Eliziária C Santos, Camila C Campos, Marcos J Marques, Raquel L M Souza, Rômulo D Novaes. Doxycycline hyclate stimulates inducible nitric oxide synthase and arginase imbalance, potentiating inflammatory and oxidative lung damage in schistosomiasis. Biomedical journal. 2022 12; 45(6):857-869. doi: 10.1016/j.bj.2021.12.007. [PMID: 34971826]
  • M Swedha, Mohammad K Okla, Saud S Al-Amri, Ibrahim A Alaraidh, Abdullah A Al-Ghamdi, Asmaa Mohebaldin, Mostafa A Abdel-Maksoud, Mohammed Aufy, Christian R Studenik, Ajith M Thomas, Lija L Raju, S Sudheer Khan. Green synthesis of two-electron centre based ZnO/NiCo2S4 QDs-OVs using Punica granatum fruit peel extract for an exceptional visible light photocatalytic degradation of doxycycline and ciprofloxacin. Chemosphere. 2022 Oct; 304(?):135225. doi: 10.1016/j.chemosphere.2022.135225. [PMID: 35697102]
  • Nozomi Nishimura, Masaya Yokota, Shunjiro Kurihara, Arifumi Iwata, Takahiro Kageyama, Takashi Ito, Aiko Saku, Yuko Maezawa, Koichi Hirose, Hiroshi Nakajima. Airway epithelial STAT3 inhibits allergic inflammation via upregulation of stearoyl-CoA desaturase 1. Allergology international : official journal of the Japanese Society of Allergology. 2022 Oct; 71(4):520-527. doi: 10.1016/j.alit.2022.05.002. [PMID: 35660131]
  • Menglong Geng, Hui Gao, Baolin Wang, Kun Huang, Xiaoyan Wu, Chunmei Liang, Shuangqin Yan, Yan Han, Peng Ding, Wei Wang, Sheng Wang, Peng Zhu, Kaiyong Liu, Yunxia Cao, Fangbiao Tao. Urinary tetracycline antibiotics exposure during pregnancy and maternal thyroid hormone parameters: A repeated measures study. The Science of the total environment. 2022 Sep; 838(Pt 2):156146. doi: 10.1016/j.scitotenv.2022.156146. [PMID: 35605876]
  • Jia-Xin He, Hou-Qun Yuan, Yu-Fei Zhong, Xiong-Xin Peng, Yi-Fan Xia, Si-Yi Liu, Qing Fan, Jun-Lan Yang, Ke Deng, Xiao-Ying Wang, Guang-Ming Bao. A luminescent Eu3+-functionalized MOF for sensitive and rapid detection of tetracycline antibiotics in swine wastewater and pig kidney. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2022 Sep; 277(?):121252. doi: 10.1016/j.saa.2022.121252. [PMID: 35447556]
  • Sunday J Olusegun, Nelcy D S Mohallem, Virginia S T Ciminelli. Reducing the negative impact of ceftriaxone and doxycycline in aqueous solutions using ferrihydrite/plant-based composites: mechanism pathway. Environmental science and pollution research international. 2022 Sep; 29(44):66547-66561. doi: 10.1007/s11356-022-20561-y. [PMID: 35503153]
  • Kathryn R Hayden, Matthew Jones, Kyle R Elkin, Michael J Shreve, William Irvin Clees, Shirley Clark, Michael L Mashtare, Tamie L Veith, Herschel A Elliott, John E Watson, Justin Silverman, Thomas L Richard, Andrew F Read, Heather E Preisendanz. Impacts of the COVID-19 pandemic on pharmaceuticals in wastewater treated for beneficial reuse: Two case studies in central Pennsylvania. Journal of environmental quality. 2022 Sep; 51(5):1066-1082. doi: 10.1002/jeq2.20398. [PMID: 35919971]
  • Li Kong, Shuixin Yu, Lvfen Gu, Menglong Geng, Dongmei Zhang, Hongjuan Cao, Annuo Liu, Qunan Wang, Sufang Wang, Fangbiao Tao, Kaiyong Liu. Associations of typical antibiotic residues with elderly blood lipids and dyslipidemia in West Anhui, China. Ecotoxicology and environmental safety. 2022 Jul; 242(?):113889. doi: 10.1016/j.ecoenv.2022.113889. [PMID: 35853362]
  • Phuong Thi Thu Nguyen, Ha Viet Pham, Dung Hoang Van, Linh Van Pham, Hoi Thanh Nguyen, Hung Van Nguyen. Randomized controlled trial of the relative efficacy of high-dose intravenous ceftriaxone and oral cefixime combined with doxycycline for the treatment of Chlamydia trachomatis and Neisseria gonorrhoeae co-infection. BMC infectious diseases. 2022 Jul; 22(1):607. doi: 10.1186/s12879-022-07595-w. [PMID: 35810277]
  • Klaudia Stando, Ewa Korzeniewska, Ewa Felis, Monika Harnisz, Sylwia Bajkacz. Uptake of Pharmaceutical Pollutants and Their Metabolites from Soil Fertilized with Manure to Parsley Tissues. Molecules (Basel, Switzerland). 2022 Jul; 27(14):. doi: 10.3390/molecules27144378. [PMID: 35889250]
  • Wei Gao, Fuquan Fang, Tianna J Xia, Yan Zhang, Jiehao Sun, Qiaolin Wu, Weijian Wang. Doxycycline can reduce glycocalyx shedding by inhibiting matrix metalloproteinases in patients undergoing cardiopulmonary bypass: A randomized controlled trial. Microvascular research. 2022 07; 142(?):104381. doi: 10.1016/j.mvr.2022.104381. [PMID: 35588887]
  • Kenneth T Lewis, Lily R Oles, Ormond A MacDougald. Tetracycline response element driven Cre causes ectopic recombinase activity independent of transactivator element. Molecular metabolism. 2022 07; 61(?):101501. doi: 10.1016/j.molmet.2022.101501. [PMID: 35452876]
  • Breanna M Scorza, Kurayi G Mahachi, Arin D Cox, Angela J Toepp, Danielle Pessoa-Pereira, Phyllis Tyrrell, Jesse Buch, Jennifer A Foltz, Dean Lee, Christine A Petersen. Role of NK-Like CD8+ T Cells during Asymptomatic Borrelia burgdorferi Infection. Infection and immunity. 2022 05; 90(5):e0055521. doi: 10.1128/iai.00555-21. [PMID: 35416707]
  • Anna Dzimitrowicz, Magda Caban, Dominik Terefinko, Pawel Pohl, Piotr Jamroz, Weronika Babinska, Piotr Cyganowski, Piotr Stepnowski, Ewa Lojkowska, Wojciech Sledz, Agata Motyka-Pomagruk. Application of pulse-modulated radio-frequency atmospheric pressure glow discharge for degradation of doxycycline from a flowing liquid solution. Scientific reports. 2022 05; 12(1):7354. doi: 10.1038/s41598-022-11088-w. [PMID: 35513687]
  • Satish Kumar Sharma, Pankaj Bhatt, Syed Mohammed Basheeruddin Asdaq, Mohammed Kanan Alshammari, Abeer Alanazi, Naif Saleh Alrasheedi, Bader Abdullah Alrashdi, Saad Saleh Alyami, Bshayer Hamdan Alhazmi, Perwaiz Alam, Prerna Sharma, Ritu Tomar, Mandeep K Arora, Mohd Imran. Combined therapy with ivermectin and doxycycline can effectively alleviate the cytokine storm of COVID-19 infection amid vaccination drive: A narrative review. Journal of infection and public health. 2022 May; 15(5):566-572. doi: 10.1016/j.jiph.2022.03.014. [PMID: 35462191]
  • Yuan Gao, Zihe Zhang, Zhicai Lun, Liping Gong, Anran Xu, Xiuyun Li. Synergistic Effects of Fluconazole Combined with Doxycycline Against Dual-Species Cultures of Candida albicans and Staphylococcus epidermidis and the Mechanisms of Action. Microbial drug resistance (Larchmont, N.Y.). 2022 May; 28(5):525-535. doi: 10.1089/mdr.2021.0301. [PMID: 35363560]
  • Volodymyr Volodymyrovych Bezruk, Igor Dmytrovych Shkrobanets, Oleksii Serhiiovych Godovanets, Oleksandr Hryhorovych Buriak, Olga Ivanivna Pervozvanska, Ludmila Mykhailivna Honcharuk, Nina Ivanivna Voytkevich, Olena Victorivna Makarova, Oksana Ivanivna Yurkiv, Michael Ivanovych Sheremet, Mykhailo Mykhailovich Hresko, Mariya Ivanivna Velia, Svyatoslava Vasylivna Yurniuk, Maryna Dmytrivna Hresko, Tetiana Sergiivna Bulyk, Larysa Vasylyvna Rynzhuk. Management of antibacterial therapy of infectious and inflammatory diseases of the urinary tract in children and regional peculiarities during the COVID-19 pandemic. Journal of medicine and life. 2022 May; 15(5):617-619. doi: 10.25122/jml-2021-0293. [PMID: 35815078]
  • Preetha Shridas, Ailing Ji, Andrea C Trumbauer, Victoria P Noffsinger, Steve W Leung, Adam J Dugan, Sean E Thatcher, Lisa A Cassis, Frederick C de Beer, Nancy R Webb, Lisa R Tannock. Adipocyte-Derived Serum Amyloid A Promotes Angiotensin II-Induced Abdominal Aortic Aneurysms in Obese C57BL/6J Mice. Arteriosclerosis, thrombosis, and vascular biology. 2022 05; 42(5):632-643. doi: 10.1161/atvbaha.121.317225. [PMID: 35344382]
  • Manas Kumar Panigrahi, Hemanta Kumar Nayak, Subash Chandra Samal. A recent surge of doxycycline-induced pill esophagitis during the corona virus disease 2019 (COVID-19) pandemic. Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology. 2022 04; 41(2):206-207. doi: 10.1007/s12664-021-01224-1. [PMID: 34994946]
  • Lu Ding, Yatian Cao, Huihui Li, Fuxiang Wang, Dong-Yu Guo, Weiting Yang, Qinhe Pan. A ratiometric fluorescence-scattering sensor for rapid, sensitive and selective detection of doxycycline in animal foodstuffs. Food chemistry. 2022 Mar; 373(Pt B):131669. doi: 10.1016/j.foodchem.2021.131669. [PMID: 34863605]
  • Eugenia Sancho, Fabio Granados-Chinchilla, Elías Barquero-Calvo. Determination of streptomycin and doxycycline using LC/MS towards an effective treatment against an experimental Brucella abortus infection in mice. Journal of microbiological methods. 2022 03; 194(?):106436. doi: 10.1016/j.mimet.2022.106436. [PMID: 35219705]
  • Haralampos Milionis, Konstantinos Kostikas. Is it prime time to consider a clinical trial of doxycycline for the management of COVID-19?. Postgraduate medical journal. 2022 03; 98(e2):e107. doi: 10.1136/postgradmedj-2020-139358. [PMID: 35232857]
  • Yucong Fan, Weihua Yu, Yunwen Liao, Xiaohui Jiang, Zhonghua Wang, Zhengjun Cheng. Ratiometric detection of doxycycline in pharmaceutical based on dual ligands-enhanced copper nanoclusters. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2022 Feb; 267(Pt 1):120509. doi: 10.1016/j.saa.2021.120509. [PMID: 34688060]
  • Gurleenjot Kaur, Neetu Singh, Anita Rajor. Adsorptive decontamination of doxycycline hydrochloride via Prosopis juliflora activated carbon: Parameter optimization and disposal study. Water environment research : a research publication of the Water Environment Federation. 2022 Feb; 94(2):e10687. doi: 10.1002/wer.10687. [PMID: 35165966]
  • Scott Marston, Gudrun Mirick Mueller, Arick Sabin, Glen T Hansen, Bruce Lindgren, Conrado Aparicio, Alexandra R Armstrong, Ole H Larsen, Andrew Schmidt, Richard Kyle, Ramon Gustilo, Dean Tsukayama, Joan Bechtold, Mats Bue. Systemic versus free antibiotic delivery in preventing acute exogenous implant related infection in a rat model. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2022 02; 40(2):429-438. doi: 10.1002/jor.25052. [PMID: 33913540]
  • Karla E Merz, Jinhee Hwang, Chunxue Zhou, Rajakrishnan Veluthakal, Erika M McCown, Angelica Hamilton, Eunjin Oh, Wenting Dai, Patrick T Fueger, Lei Jiang, Janice M Huss, Debbie C Thurmond. Enrichment of the exocytosis protein STX4 in skeletal muscle remediates peripheral insulin resistance and alters mitochondrial dynamics via Drp1. Nature communications. 2022 01; 13(1):424. doi: 10.1038/s41467-022-28061-w. [PMID: 35058456]
  • Kai-Ni Shen, Wei-Jun Fu, Yu Wu, Yu-Jun Dong, Zhong-Xia Huang, Yong-Qiang Wei, Chun-Rui Li, Chun-Yan Sun, Ye Chen, Hui-Lei Miao, Yue-Lun Zhang, Xin-Xin Cao, Dao-Bin Zhou, Jian Li. Doxycycline Combined With Bortezomib-Cyclophosphamide-Dexamethasone Chemotherapy for Newly Diagnosed Cardiac Light-Chain Amyloidosis: A Multicenter Randomized Controlled Trial. Circulation. 2022 01; 145(1):8-17. doi: 10.1161/circulationaha.121.055953. [PMID: 34503349]
  • Selamawit Girma, Wondwossen Amogne. Investigating latent syphilis in HIV treatment-experienced Ethiopians and response to therapy. PloS one. 2022; 17(7):e0270878. doi: 10.1371/journal.pone.0270878. [PMID: 35819944]
  • Elisabete Ferreira, Zaida L Almeida, Pedro F Cruz, Marta Silva E Sousa, Paula Veríssimo, Rui M M Brito. Searching for the Best Transthyretin Aggregation Protocol to Study Amyloid Fibril Disruption. International journal of molecular sciences. 2021 Dec; 23(1):. doi: 10.3390/ijms23010391. [PMID: 35008816]
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