Cilastatin (BioDeep_00000397743)

Main id: BioDeep_00000002152

 


代谢物信息卡片


7-{[(2R)-2-amino-2-carboxyethyl]sulfanyl}-2-{[(1S)-2,2-dimethylcyclopropyl]formamido}hept-2-enoic acid

化学式: C16H26N2O5S (358.1562)
中文名称: 西司他丁
谱图信息: 最多检出来源 Homo sapiens(blood) 19.33%

分子结构信息

SMILES: CC1(C)C[C@@H]1C(=O)N/C(=C\CCCCSC[C@@H](C(=O)O)N)/C(=O)O
InChI: InChI=1S/C16H26N2O5S/c1-16(2)8-10(16)13(19)18-12(15(22)23)6-4-3-5-7-24-9-11(17)14(20)21/h6,10-11H,3-5,7-9,17H2,1-2H3,(H,18,19)(H,20,21)(H,22,23)/b12-6+/t10-,11+/m1/s1

描述信息

The thioether resulting from the formal oxidative coupling of the thiol group of L-cysteine with the 7-position of (2Z)-2-({[(1S)-2,2-dimethylcyclopropyl]carbonyl}amino)hept-2-enoic acid. It is an inhibitor of dehydropeptidase I (membrane dipeptidase, 3.4.13.19), an enzyme found in the brush border of renal tubes and responsible for degrading the antibiotic imipenem. Cilastatin is therefore administered (as the sodium salt) with imipenem to prolong the antibacterial effect of the latter by preventing its renal metabolism to inactive and potentially nephrotoxic products. Cilastatin also acts as a leukotriene D4 dipeptidase inhibitor, preventing the metabolism of leukotriene D4 to leukotriene E4.
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor
CONFIDENCE standard compound; INTERNAL_ID 2129
CONFIDENCE standard compound; EAWAG_UCHEM_ID 2555
EAWAG_UCHEM_ID 2555; CONFIDENCE standard compound

同义名列表

4 个代谢物同义名

7-{[(2R)-2-amino-2-carboxyethyl]sulfanyl}-2-{[(1S)-2,2-dimethylcyclopropyl]formamido}hept-2-enoic acid; Cilastatin; C16-H26-N2-O5-S; Cilastatin



数据库引用编号

51 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ABCB1, AMOT, ANPEP, BCL2, CASP3, CDH1, FKBP5, IQGAP1
Endoplasmic reticulum membrane 1 BCL2
Nucleus 5 BCL2, CASP3, CDH1, FKBP5, IQGAP1
cytosol 8 AMOT, BCL2, CASP3, CDH1, FKBP5, GPT, IQGAP1, MB
dendrite 1 LRP2
trans-Golgi network 1 CDH1
nucleoplasm 4 AMOT, CASP3, CDH1, FKBP5
Cell membrane 5 ABCB1, ANPEP, CDH1, HAVCR1, IQGAP1
lamellipodium 2 AMOT, CDH1
Cell projection, axon 1 LRP2
Multi-pass membrane protein 3 ABCB1, SLC22A6, SLC22A8
cell cortex 1 IQGAP1
cell junction 2 AMOT, CDH1
cell surface 4 ABCB1, AMOT, C3, HAVCR1
glutamatergic synapse 3 AMOT, CASP3, CDH1
Golgi apparatus 2 CDH1, LRP2
Golgi membrane 1 INS
growth cone 1 IQGAP1
lysosomal membrane 2 ANPEP, LRP2
mitochondrial inner membrane 1 FECH
neuronal cell body 1 CASP3
postsynapse 1 CDH1
Lysosome 1 LRP2
endosome 1 CDH1
plasma membrane 11 ABCB1, AMOT, ANPEP, C3, CDH1, HAVCR1, IFNLR1, IQGAP1, LRP2, SLC22A6, SLC22A8
Membrane 8 ABCB1, AMOT, BCL2, CDH1, FKBP5, IFNLR1, LRP2, SLC22A6
apical plasma membrane 4 ABCB1, IQGAP1, LRP2, SLC22A8
axon 2 IQGAP1, LRP2
basolateral plasma membrane 3 IQGAP1, SLC22A6, SLC22A8
caveola 1 SLC22A6
extracellular exosome 12 ABCB1, ANPEP, C3, CDH1, FKBP5, GPT, IQGAP1, LCN2, LRP2, MB, SLC22A6, SLC22A8
endoplasmic reticulum 2 BCL2, LRP2
extracellular space 5 ANPEP, C3, IL2, INS, LCN2
perinuclear region of cytoplasm 1 CDH1
Cell junction, tight junction 1 AMOT
adherens junction 1 CDH1
bicellular tight junction 1 AMOT
mitochondrion 2 BCL2, FECH
protein-containing complex 3 BCL2, C3, SLC22A6
postsynaptic density 2 AMOT, CASP3
Single-pass type I membrane protein 4 CDH1, HAVCR1, IFNLR1, LRP2
Secreted 4 C3, IL2, INS, LCN2
extracellular region 5 C3, CDH1, IL2, INS, LCN2
cytoplasmic side of plasma membrane 2 CDH1, IQGAP1
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 2 BCL2, LRP2
mitochondrial outer membrane 1 BCL2
mitochondrial matrix 1 FECH
Cytoplasmic vesicle lumen 1 LCN2
motile cilium 1 HAVCR1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, CDH1
external side of plasma membrane 3 AMOT, ANPEP, LRP2
actin cytoskeleton 1 CDH1
slit diaphragm 1 IQGAP1
cytoplasmic vesicle 1 AMOT
midbody 1 IQGAP1
sarcoplasm 1 MB
clathrin-coated pit 1 LRP2
Single-pass type II membrane protein 1 ANPEP
Apical cell membrane 3 ABCB1, IQGAP1, LRP2
Mitochondrion inner membrane 1 FECH
pore complex 1 BCL2
focal adhesion 1 IQGAP1
microtubule 1 IQGAP1
Cell junction, adherens junction 1 CDH1
flotillin complex 1 CDH1
lateral plasma membrane 3 CDH1, IQGAP1, SLC22A8
ruffle 2 AMOT, IQGAP1
receptor complex 1 LRP2
neuron projection 1 IQGAP1
cytoplasmic ribonucleoprotein granule 1 IQGAP1
brush border membrane 1 LRP2
Golgi apparatus, trans-Golgi network 1 CDH1
Cytoplasm, cell cortex 1 IQGAP1
actin filament 2 AMOT, IQGAP1
blood microparticle 1 C3
Basolateral cell membrane 3 IQGAP1, SLC22A6, SLC22A8
endosome lumen 2 INS, LRP2
Cell projection, dendrite 1 LRP2
myelin sheath 1 BCL2
stress fiber 1 AMOT
basal plasma membrane 1 SLC22A6
secretory granule lumen 2 C3, INS
secretory granule membrane 2 ANPEP, IQGAP1
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 C3, INS
cortical actin cytoskeleton 1 IQGAP1
specific granule lumen 1 LCN2
endocytic vesicle 1 AMOT
transport vesicle 1 INS
azurophil granule lumen 1 C3
anaphase-promoting complex 1 CDH1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
clathrin-coated endocytic vesicle membrane 1 LRP2
ribonucleoprotein complex 1 IQGAP1
endoplasmic reticulum-Golgi intermediate compartment 1 ANPEP
[Isoform 2]: Nucleus 1 CDH1
Basal cell membrane 1 SLC22A6
external side of apical plasma membrane 1 ABCB1
death-inducing signaling complex 1 CASP3
apical junction complex 1 CDH1
Cell junction, desmosome 1 CDH1
desmosome 1 CDH1
Membrane, coated pit 1 LRP2
catenin complex 1 CDH1
Cytoplasm, sarcoplasm 1 MB
BAD-BCL-2 complex 1 BCL2
Cytoplasmic granule lumen 1 LCN2
interleukin-28 receptor complex 1 IFNLR1
plasma membrane bounded cell projection 1 IQGAP1


文献列表

  • Fan Wu, Ting Zhao, Yu Zhang, Yan Wang, Guoxin Liao, Baojing Zhang, Chao Wang, Xiangge Tian, Lei Feng, Bangjiang Fang, Xiaokui Huo, Xiaochi Ma. Beneficial herb-drug interaction of rhein in Jinhongtang and Imipenem/Cilastatin mediated by organic anion transporters. Journal of ethnopharmacology. 2023 Apr; ?(?):116449. doi: 10.1016/j.jep.2023.116449. [PMID: 37023835]
  • Rebeca González-Fernández, María Ángeles González-Nicolás, Manuel Morales, Julio Ávila, Alberto Lázaro, Pablo Martín-Vasallo. FKBP51, AmotL2 and IQGAP1 Involvement in Cilastatin Prevention of Cisplatin-Induced Tubular Nephrotoxicity in Rats. Cells. 2022 05; 11(9):. doi: 10.3390/cells11091585. [PMID: 35563891]
  • Estefanía Moreno-Gordaliza, Maria Dolores Marazuela, Óscar Pastor, Alberto Lázaro, María Milagros Gómez-Gómez. Lipidomics Reveals Cisplatin-Induced Renal Lipid Alterations during Acute Kidney Injury and Their Attenuation by Cilastatin. International journal of molecular sciences. 2021 Nov; 22(22):. doi: 10.3390/ijms222212521. [PMID: 34830406]
  • Katsuyuki Matsushita, Kiyoshi Mori, Turgay Saritas, Mahaba B Eiwaz, Yoshio Funahashi, Megan N Nickerson, Jessica F Hebert, Adam C Munhall, James A McCormick, Motoko Yanagita, Michael P Hutchens. Cilastatin Ameliorates Rhabdomyolysis-induced AKI in Mice. Journal of the American Society of Nephrology : JASN. 2021 10; 32(10):2579-2594. doi: 10.1681/asn.2020030263. [PMID: 34341182]
  • T Becerir, O Tokgün, S Yuksel. The therapeutic effect of Cilastatin on drug-induced nephrotoxicity: a new perspective. European review for medical and pharmacological sciences. 2021 Sep; 25(17):5436-5447. doi: 10.26355/eurrev_202109_26651. [PMID: 34533819]
  • Samuel Martinez-Erro, Francisco Navas, Eva Romaní-Cubells, Paloma Fernández-García, Victoria Morales, Raul Sanz, Rafael A García-Muñoz. Kidney-Protector Lipidic Cilastatin Derivatives as Structure-Directing Agents for the Synthesis of Mesoporous Silica Nanoparticles for Drug Delivery. International journal of molecular sciences. 2021 Jul; 22(15):. doi: 10.3390/ijms22157968. [PMID: 34360733]
  • Ci Han, Nana Guo, Yue Bu, Yahui Peng, Xueting Li, Xiaohui Ma, Mengyuan Yang, Xiaonan Jia, Jin Zhang, Xiaowei Liu, Kaijiang Yu, Changsong Wang. Intestinal microbiota and antibiotic-associated acute gastrointestinal injury in sepsis mice. Aging. 2021 03; 13(7):10099-10111. doi: 10.18632/aging.202768. [PMID: 33818419]
  • Matilde Zaballos, Mercedes Power, María Iluminada Canal-Alonso, María Ángeles González-Nicolás, Wenceslao Vasquez-Jimenez, Pablo Lozano-Lominchar, Pilar Cabrerizo-Torrente, Natividad Palencia-García, Susana Gago-Quiroga, María Dolores Ginel-Feito, Consuelo Jiménez, Alberto Lázaro, Luis González-Bayón. Effect of Cilastatin on Cisplatin-Induced Nephrotoxicity in Patients Undergoing Hyperthermic Intraperitoneal Chemotherapy. International journal of molecular sciences. 2021 Jan; 22(3):. doi: 10.3390/ijms22031239. [PMID: 33513824]
  • Masashi Arita, Satoshi Watanabe, Nobumasa Aoki, Shoji Kuwahara, Ryo Suzuki, Sawako Goto, Yuko Abe, Miho Takahashi, Miyuki Sato, Satoshi Hokari, Aya Ohtsubo, Satoshi Shoji, Koichiro Nozaki, Kosuke Ichikawa, Rie Kondo, Masachika Hayashi, Yasuyoshi Ohshima, Hideyuki Kabasawa, Michihiro Hosojima, Toshiyuki Koya, Akihiko Saito, Toshiaki Kikuchi. Combination therapy of cisplatin with cilastatin enables an increased dose of cisplatin, enhancing its antitumor effect by suppression of nephrotoxicity. Scientific reports. 2021 01; 11(1):750. doi: 10.1038/s41598-020-80853-6. [PMID: 33437029]
  • Iris H Chen, David P Nicolau, Joseph L Kuti. Imipenem/Cilastatin/Relebactam Alone and in Combination against Pseudomonas aeruginosa in the In Vitro Pharmacodynamic Model. Antimicrobial agents and chemotherapy. 2020 11; 64(12):. doi: 10.1128/aac.01764-20. [PMID: 33139283]
  • Mersedeh Shayan, Sepideh Elyasi. Cilastatin as a protective agent against drug-induced nephrotoxicity: a literature review. Expert opinion on drug safety. 2020 Aug; 19(8):999-1010. doi: 10.1080/14740338.2020.1796967. [PMID: 32666842]
  • Zhi Rao, Zi-Long Dang, Bin Li, Lei Zhu, Hong-Yan Qin, Xin-An Wu, Yu-Hui Wei. Determination of Total and Unbound Meropenem, Imipenem/Cilastatin, and Cefoperazone/Sulbactam in Human Plasma: Application for Therapeutic Drug Monitoring in Critically Ill Patients. Therapeutic drug monitoring. 2020 08; 42(4):578-587. doi: 10.1097/ftd.0000000000000736. [PMID: 32049891]
  • Yu Ah Hong, So Young Jung, Keum Jin Yang, Dai Sig Im, Kyung Hwan Jeong, Cheol Whee Park, Hyeon Seok Hwang. Cilastatin Preconditioning Attenuates Renal Ischemia-Reperfusion Injury via Hypoxia Inducible Factor-1α Activation. International journal of molecular sciences. 2020 May; 21(10):. doi: 10.3390/ijms21103583. [PMID: 32438631]
  • Pratik Bhagunde, Francheska Colon-Gonzalez, Yang Liu, Jin Wu, Shiyao Sherrie Xu, Graigory Garrett, Patricia Jumes, Kenneth Lasseter, Thomas Marbury, Matthew L Rizk, Mallika Lala, Elizabeth G Rhee, Joan R Butterton, Keith Boundy. Impact of renal impairment and human organic anion transporter inhibition on pharmacokinetics, safety and tolerability of relebactam combined with imipenem and cilastatin. British journal of clinical pharmacology. 2020 05; 86(5):944-957. doi: 10.1111/bcp.14204. [PMID: 31856304]
  • Xiaokui Huo, Qiang Meng, Changyuan Wang, Jingjing Wu, Chong Wang, Yanna Zhu, Xiaodong Ma, Huijun Sun, Kexin Liu. Protective effect of cilastatin against diclofenac-induced nephrotoxicity through interaction with diclofenac acyl glucuronide via organic anion transporters. British journal of pharmacology. 2020 05; 177(9):1933-1948. doi: 10.1111/bph.14957. [PMID: 32000294]
  • Kang Luo, Sun Woo Lim, Jian Jin, Long Jin, Hyo Wook Gil, Dai Sig Im, Hyeon Seok Hwang, Chul Woo Yang. Cilastatin protects against tacrolimus-induced nephrotoxicity via anti-oxidative and anti-apoptotic properties. BMC nephrology. 2019 06; 20(1):221. doi: 10.1186/s12882-019-1399-6. [PMID: 31200653]
  • Estefanía Moreno-Gordaliza, Diego Esteban-Fernández, Alberto Lázaro, Sarah Aboulmagd, Blanca Humanes, Alberto Tejedor, Michael W Linscheid, M Milagros Gómez-Gómez. Lipid imaging for visualizing cilastatin amelioration of cisplatin-induced nephrotoxicity. Journal of lipid research. 2018 09; 59(9):1561-1574. doi: 10.1194/jlr.m080465. [PMID: 30049708]
  • Weihong Shi, Mingyang Duan, Ligang Jie, Weifeng Sun. A successful treatment of severe systemic lupus erythematosus caused by occult pulmonary infection-associated with hemophagocytic syndrome: A case report. Medicine. 2018 May; 97(19):e0595. doi: 10.1097/md.0000000000010595. [PMID: 29742693]
  • Matthew L Rizk, Elizabeth G Rhee, Patricia A Jumes, Mark H Gotfried, Tian Zhao, Eric Mangin, Sheng Bi, Cynthia M Chavez-Eng, Zufei Zhang, Joan R Butterton. Intrapulmonary Pharmacokinetics of Relebactam, a Novel β-Lactamase Inhibitor, Dosed in Combination with Imipenem-Cilastatin in Healthy Subjects. Antimicrobial agents and chemotherapy. 2018 03; 62(3):. doi: 10.1128/aac.01411-17. [PMID: 29311084]
  • Gabriel Hundeshagen, David N Herndon, Karel D Capek, Ludwik K Branski, Charles D Voigt, Elizabeth A Killion, Janos Cambiaso-Daniel, Michaela Sljivich, Andrew De Crescenzo, Ronald P Mlcak, Michael P Kinsky, Celeste C Finnerty, William B Norbury. Co-administration of vancomycin and piperacillin-tazobactam is associated with increased renal dysfunction in adult and pediatric burn patients. Critical care (London, England). 2017 12; 21(1):318. doi: 10.1186/s13054-017-1899-3. [PMID: 29262848]
  • Amal Tahri, Kamilia Ksouda, Rim Kallel, Salima Daoud, Tahia Boudawara, Khaled Mounir Zeghal, Zouheir Sahnoun. A carbapenem antibiotic imipenem/cilastatin induces an oxidative stress-status and gonadotoxic effects in « wistar » rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Nov; 95(?):308-316. doi: 10.1016/j.biopha.2017.08.039. [PMID: 28858728]
  • Blanca Humanes, Sonia Camaño, Jose Manuel Lara, Venkatta Sabbisetti, María Ángeles González-Nicolás, Joseph V Bonventre, Alberto Tejedor, Alberto Lázaro. Cisplatin-induced renal inflammation is ameliorated by cilastatin nephroprotection. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2017 Oct; 32(10):1645-1655. doi: 10.1093/ndt/gfx005. [PMID: 28340076]
  • Dai Sig Im, Hye Jin Shin, Keum Jin Yang, So Young Jung, Ho Yeon Song, Hyeon Seok Hwang, Hyo-Wook Gil. Cilastatin attenuates vancomycin-induced nephrotoxicity via P-glycoprotein. Toxicology letters. 2017 Aug; 277(?):9-17. doi: 10.1016/j.toxlet.2017.05.023. [PMID: 28549670]
  • Yoshihisa Hori, Nobumasa Aoki, Shoji Kuwahara, Michihiro Hosojima, Ryohei Kaseda, Sawako Goto, Tomomichi Iida, Shankhajit De, Hideyuki Kabasawa, Reika Kaneko, Hiroyuki Aoki, Yoshinari Tanabe, Hiroshi Kagamu, Ichiei Narita, Toshiaki Kikuchi, Akihiko Saito. Megalin Blockade with Cilastatin Suppresses Drug-Induced Nephrotoxicity. Journal of the American Society of Nephrology : JASN. 2017 Jun; 28(6):1783-1791. doi: 10.1681/asn.2016060606. [PMID: 28052987]
  • Mario Martínez-Florensa, Marta Consuegra-Fernández, Fernando Aranda, Noelia Armiger-Borràs, Marianna Di Scala, Esther Carrasco, Jerónimo Pachón, Jordi Vila, Gloria González-Aseguinolaza, Francisco Lozano. Protective Effects of Human and Mouse Soluble Scavenger-Like CD6 Lymphocyte Receptor in a Lethal Model of Polymicrobial Sepsis. Antimicrobial agents and chemotherapy. 2017 01; 61(1):. doi: 10.1128/aac.01391-16. [PMID: 27895015]
  • Bradley A Boucher, Joanna Q Hudson, David M Hill, Joseph M Swanson, G Christopher Wood, S Casey Laizure, Angela Arnold-Ross, Zhe-Yi Hu, William L Hickerson. Pharmacokinetics of Imipenem/Cilastatin Burn Intensive Care Unit Patients Undergoing High-Dose Continuous Venovenous Hemofiltration. Pharmacotherapy. 2016 12; 36(12):1229-1237. doi: 10.1002/phar.1866. [PMID: 27862103]
  • Chien-Chih Wu, Tsung-Yu Pai, Fei-Yuan Hsiao, Li-Jiuan Shen, Fe-Lin Lin Wu. The Effect of Different Carbapenem Antibiotics (Ertapenem, Imipenem/Cilastatin, and Meropenem) on Serum Valproic Acid Concentrations. Therapeutic drug monitoring. 2016 10; 38(5):587-92. doi: 10.1097/ftd.0000000000000316. [PMID: 27322166]
  • L Y Deng, Z C Yang, Y L Gong, G T Huang, S P Yin, B Jiang, Y Z Peng. [Therapeutic effect of phages on extensively drug-resistant Acinetobacter baumannii-induced sepsis in mice]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns. 2016 Sep; 32(9):523-8. doi: 10.3760/cma.j.issn.1009-2587.2016.09.003. [PMID: 27647067]
  • Naoki Kuroshima, Takayuki Tanaka, Tamotsu Kuroki, Amane Kitasato, Tomohiko Adachi, Shinichiro Ono, Hajime Matsushima, Takanori Hirayama, Akihiko Soyama, Masaaki Hidaka, Mitsuhisa Takatsuki, Susumu Eguchi. Triple-drug therapy to prevent pancreatic fistula after pancreatectomy in a rat model. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]. 2016 Sep; 16(5):917-21. doi: 10.1016/j.pan.2016.06.011. [PMID: 27396917]
  • P Wilkowski, M Ciszek, K Dobrzaniecka, J Sańko-Resmer, A Łabuś, K Grygiel, T Grochowiecki, G Młynarczyk, L Pączek. Successful Treatment of Urinary Tract Infection in Kidney Transplant Recipients Caused by Multiresistant Klebsiella pneumoniae Producing New Delhi Metallo-Beta-Lactamase (NDM-1) With Strains Genotyping. Transplantation proceedings. 2016 Jun; 48(5):1576-9. doi: 10.1016/j.transproceed.2016.01.060. [PMID: 27496450]
  • Yusuke Shono, Melissa D Docampo, Jonathan U Peled, Suelen M Perobelli, Enrico Velardi, Jennifer J Tsai, Ann E Slingerland, Odette M Smith, Lauren F Young, Jyotsna Gupta, Sophia R Lieberman, Hillary V Jay, Katya F Ahr, Kori A Porosnicu Rodriguez, Ke Xu, Marco Calarfiore, Hendrik Poeck, Silvia Caballero, Sean M Devlin, Franck Rapaport, Jarrod A Dudakov, Alan M Hanash, Boglarka Gyurkocza, George F Murphy, Camilla Gomes, Chen Liu, Eli L Moss, Shannon B Falconer, Ami S Bhatt, Ying Taur, Eric G Pamer, Marcel R M van den Brink, Robert R Jenq. Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice. Science translational medicine. 2016 05; 8(339):339ra71. doi: 10.1126/scitranslmed.aaf2311. [PMID: 27194729]
  • Anne Fournier, Philippe Eggimann, Jean-Luc Pagani, Jean-Pierre Revelly, Laurent A Decosterd, Oscar Marchetti, André Pannatier, Pierre Voirol, Yok-Ai Que. Impact of the introduction of real-time therapeutic drug monitoring on empirical doses of carbapenems in critically ill burn patients. Burns : journal of the International Society for Burn Injuries. 2015 Aug; 41(5):956-68. doi: 10.1016/j.burns.2015.01.001. [PMID: 25678084]
  • Richard D Moulton, Kenneth J Ruterbories, David W Bedwell, Michael A Mohutsky. In vitro characterization of the bioconversion of pomaglumetad methionil, a novel metabotropic glutamate 2/3 receptor agonist peptide prodrug. Drug metabolism and disposition: the biological fate of chemicals. 2015 May; 43(5):756-61. doi: 10.1124/dmd.114.062893. [PMID: 25755052]
  • Blanca Humanes, Juan Carlos Jado, Sonia Camaño, Virginia López-Parra, Ana María Torres, Luís Antonio Álvarez-Sala, Emilia Cercenado, Alberto Tejedor, Alberto Lázaro. Protective Effects of Cilastatin against Vancomycin-Induced Nephrotoxicity. BioMed research international. 2015; 2015(?):704382. doi: 10.1155/2015/704382. [PMID: 26504822]
  • Kyung-Mee Park, Hyun-Suk Nam, Heung-Myong Woo. Successful management of multidrug-resistant Pseudomonas aeruginosa pneumonia after kidney transplantation in a dog. The Journal of veterinary medical science. 2013 Nov; 75(11):1529-33. doi: 10.1292/jvms.13-0194. [PMID: 23842146]
  • Zhe-Yi Hu, Bradley A Boucher, S Casey Laizure, Vanessa L Herring, Robert B Parker, William L Hickerson. Nonvolatile salt-free stabilizer for the quantification of polar imipenem and cilastatin in human plasma using hydrophilic interaction chromatography/quadrupole mass spectrometry with contamination sensitive off-axis electrospray. Journal of mass spectrometry : JMS. 2013 Aug; 48(8):945-50. doi: 10.1002/jms.3240. [PMID: 23893642]
  • Mehdi Nematbakhsh, Hamid Nasri. Cisplatin nephrotoxicity may be sex related. Kidney international. 2013 Jun; 83(6):1201. doi: 10.1038/ki.2013.37. [PMID: 23728006]
  • Gabriela A Albarellos, Graciela A Denamiel, Laura Montoya, Pamela C Quaine, Martín P Lupi, María F Landoni. Pharmacokinetics of imipenem after intravenous, intramuscular and subcutaneous administration to cats. Journal of feline medicine and surgery. 2013 Jun; 15(6):483-7. doi: 10.1177/1098612x12471526. [PMID: 23253883]
  • Alberto Lazaro, Blanca Humanes, Juan C Jado, Alberto Tejedor. The authors reply. Kidney international. 2013 Jun; 83(6):1201-2. doi: 10.1038/ki.2013.42. [PMID: 23728005]
  • Hai-yan Yin, Xiao-ling Ye, Rui Zhang, You-feng Zhu. [Domestic imipenem cilastatin sodium for the treatment of severe aspiration pneumonia, a curative effect observation]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue. 2012 Oct; 24(10):628-31. doi: NULL. [PMID: 23040783]
  • Blanca Humanes, Alberto Lazaro, Sonia Camano, Estefanía Moreno-Gordaliza, Jose A Lazaro, Montserrat Blanco-Codesido, Jose M Lara, Alberto Ortiz, Maria M Gomez-Gomez, Pablo Martín-Vasallo, Alberto Tejedor. Cilastatin protects against cisplatin-induced nephrotoxicity without compromising its anticancer efficiency in rats. Kidney international. 2012 Sep; 82(6):652-63. doi: 10.1038/ki.2012.199. [PMID: 22718191]
  • Xiaojiao Zheng, Guoxiang Xie, Aihua Zhao, Linjing Zhao, Chun Yao, Norman H L Chiu, Zhanxiang Zhou, Yuqian Bao, Weiping Jia, Jeremy K Nicholson, Wei Jia. The footprints of gut microbial-mammalian co-metabolism. Journal of proteome research. 2011 Dec; 10(12):5512-22. doi: 10.1021/pr2007945. [PMID: 21970572]
  • Estefanía Moreno-Gordaliza, Charlotte Giesen, Alberto Lázaro, Diego Esteban-Fernández, Blanca Humanes, Benito Cañas, Ulrich Panne, Alberto Tejedor, Norbert Jakubowski, M Milagros Gómez-Gómez. Elemental bioimaging in kidney by LA-ICP-MS as a tool to study nephrotoxicity and renal protective strategies in cisplatin therapies. Analytical chemistry. 2011 Oct; 83(20):7933-40. doi: 10.1021/ac201933x. [PMID: 21913725]
  • Sonia Camano, Alberto Lazaro, Estefania Moreno-Gordaliza, Ana M Torres, Carmen de Lucas, Blanca Humanes, Jose A Lazaro, M Milagros Gomez-Gomez, Lisardo Bosca, Alberto Tejedor. Cilastatin attenuates cisplatin-induced proximal tubular cell damage. The Journal of pharmacology and experimental therapeutics. 2010 Aug; 334(2):419-29. doi: 10.1124/jpet.110.165779. [PMID: 20435919]
  • Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance. Journal of medicinal chemistry. 2009 Aug; 52(15):4844-52. doi: 10.1021/jm900403j. [PMID: 19445515]
  • Yang Xu, Wei Xie, Cynthia M Miller-Stein, Eric J Woolf. Hydrophilic interaction chromatography/tandem mass spectrometry for the simultaneous determination of three polar non-structurally related compounds, imipenem, cilastatin and an investigational beta-lactamase inhibitor, MK-4698, in biological matrices. Rapid communications in mass spectrometry : RCM. 2009 Jul; 23(14):2195-205. doi: 10.1002/rcm.4138. [PMID: 19530150]
  • Ping Xue, Li-Hui Deng, Zhao-Da Zhang, Xiao-Nan Yang, Mei-Hua Wan, Bing Song, Qing Xia. Effect of antibiotic prophylaxis on acute necrotizing pancreatitis: results of a randomized controlled trial. Journal of gastroenterology and hepatology. 2009 May; 24(5):736-42. doi: 10.1111/j.1440-1746.2008.05758.x. [PMID: 19220676]
  • Jong Myung Kim, Jong Ryul Ha, Se Woong Oh, Hong Gi Kim, Jin Man Lee, Byung Oh Kim, Dong Geun Lee, Sang-Han Lee, Jong Guk Kim. Comparison of in vivo nephrotoxicity in the rabbit by a pyrrolidinyl-thio Carbapenem CW-270031. Journal of microbiology and biotechnology. 2008 Nov; 18(11):1768-72. doi: 10.4014/jmb.0800.106. [PMID: 19047819]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • M Aboagye-Kumi, A Yango, S Fischer, J Donahue, P Morrissey, N Taylor, A Gautam, C Mendonca, S Kumar, R Gohh. Acute disseminated encephalomyelitis in a renal transplant recipient: a case report. Transplantation proceedings. 2008 Jun; 40(5):1751-3. doi: 10.1016/j.transproceed.2007.11.073. [PMID: 18589186]
  • Takayuki Katsube, Yoshinori Yamano, Yoshitaka Yano. Pharmacokinetic-pharmacodynamic modeling and simulation for in vivo bactericidal effect in murine infection model. Journal of pharmaceutical sciences. 2008 Apr; 97(4):1606-14. doi: 10.1002/jps.21062. [PMID: 17705288]
  • Hironori Ishibashi, S Ohta, M Hirose, T Shirasu, H Muro, N Tanio, K Suzuki, T Etoh. [Postoperative penicillin-resistant streptococcus pneumonia in lung cancer patient]. Kyobu geka. The Japanese journal of thoracic surgery. 2008 Mar; 61(3):199-203. doi: NULL. [PMID: 18323184]
  • Eugene Hagiwara, Jaya Nath. Choroid plexitis in a case of systemic nocardiosis. Emergency radiology. 2007 Oct; 14(5):337-43. doi: 10.1007/s10140-007-0604-2. [PMID: 17406912]
  • Samir G Sakka, Anna K Glauner, Jürgen B Bulitta, Martina Kinzig-Schippers, Wolfgang Pfister, George L Drusano, Fritz Sörgel. Population pharmacokinetics and pharmacodynamics of continuous versus short-term infusion of imipenem-cilastatin in critically ill patients in a randomized, controlled trial. Antimicrobial agents and chemotherapy. 2007 Sep; 51(9):3304-10. doi: 10.1128/aac.01318-06. [PMID: 17620371]
  • Rajiv Mallick, Steven Sun, Scott R Schell. Predictors of efficacy and health resource utilization in treatment of complicated intra-abdominal infections: evidence for pooled clinical studies comparing tigecycline with imipenem-cilastatin. Surgical infections. 2007 Apr; 8(2):159-72. doi: 10.1089/sur.2005.058. [PMID: 17437361]
  • JongMyeung Kim, Jong Ryul Ha, Se Woong Oh, Hong Gi Kim, Jin-Man Lee, Dong Gun Lee, Sang-Han Lee, Jong Guk Kim. CW-270033, a novel pyrrolidinyl-thio carbapenem, has potent antimicrobial activity in vitro and in vivo. Biological & pharmaceutical bulletin. 2007 Mar; 30(3):575-9. doi: 10.1248/bpb.30.575. [PMID: 17329859]
  • A Tejedor, A M Torres, M Castilla, J A Lazaro, C de Lucas, C Caramelo. Cilastatin protection against cyclosporin A-induced nephrotoxicity: clinical evidence. Current medical research and opinion. 2007 Mar; 23(3):505-13. doi: 10.1185/030079906x167633. [PMID: 17355732]
  • M P Rodighiero, R Dell'Aquila, M Bonello, E Spanò, P Di Loreto, F Nalesso, C Ronco. Successful use of sodium hypochlorite pack plus systemic and local antibiotic therapy for the treatment of pseudomonas infection of peritoneal dialysis catheter exit-site. Contributions to nephrology. 2007; 154(?):125-128. doi: 10.1159/000096957. [PMID: 17099307]
  • Eric Giannoni, Philippe Moreillon, Jacques Cotting, Adrien Moessinger, Jacques Bille, Laurent Décosterd, Giorgio Zanetti, Paul Majcherczyk, Denis Bugnon. Prospective determination of plasma imipenem concentrations in critically ill children. Antimicrobial agents and chemotherapy. 2006 Jul; 50(7):2563-8. doi: 10.1128/aac.01149-05. [PMID: 16801447]
  • Alison Cotton, Bryony Dean Franklin, Stephen Brett, Alison Holmes. Using imipenem and cilastatin during continuous renal replacement therapy. Pharmacy world & science : PWS. 2005 Oct; 27(5):371-5. doi: 10.1007/s11096-005-1636-x. [PMID: 16341743]
  • J A Orsini, P J Moate, R C Boston, T Norman, J Engiles, C E Benson, R Poppenga. Pharmacokinetics of imipenem-cilastatin following intravenous administration in healthy adult horses. Journal of veterinary pharmacology and therapeutics. 2005 Aug; 28(4):355-61. doi: 10.1111/j.1365-2885.2005.00667.x. [PMID: 16050815]
  • Douglas N Fish, Isaac Teitelbaum, Edward Abraham. Pharmacokinetics and pharmacodynamics of imipenem during continuous renal replacement therapy in critically ill patients. Antimicrobial agents and chemotherapy. 2005 Jun; 49(6):2421-8. doi: 10.1128/aac.49.6.2421-2428.2005. [PMID: 15917542]
  • Christine T Ong, Joseph L Kuti, David P Nicolau. Pharmacodynamic modeling of imipenem-cilastatin, meropenem, and piperacillin-tazobactam for empiric therapy of skin and soft tissue infections: a report from the OPTAMA Program. Surgical infections. 2005; 6(4):419-26. doi: 10.1089/sur.2005.6.419. [PMID: 16433606]
  • Stéphanie Badiou, Hélène Bellet, Sylvain Lehmann, Jean-Paul Cristol, Samir Jaber. Elevated plasma cysteinylglycine levels caused by cilastatin-associated antibiotic treatment. Clinical chemistry and laboratory medicine. 2005; 43(3):332-4. doi: 10.1515/cclm.2005.057. [PMID: 15843241]
  • María Pérez, Manuela Castilla, Ana María Torres, Jose Antonio Lázaro, Elisabeth Sarmiento, Alberto Tejedor. Inhibition of brush border dipeptidase with cilastatin reduces toxic accumulation of cyclosporin A in kidney proximal tubule epithelial cells. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2004 Oct; 19(10):2445-55. doi: 10.1093/ndt/gfh397. [PMID: 15252165]
  • Tomoki Furuya, Takehiko Soeno, Masafumi Komatsu. [Strategy for bacterial translocation in acute pancreatitis]. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology. 2004 May; 101(5):502-9. doi: NULL. [PMID: 15171213]
  • Reiner Schaumann, Rosemarie Blatz, Joerg Beer, Grit Ackermann, Arne C Rodloff. Effect of moxifloxacin versus imipenem/cilastatin treatment on the mortality of mice infected intravenously with different strains of Bacteroides fragilis and Escherichia coli. The Journal of antimicrobial chemotherapy. 2004 Feb; 53(2):318-24. doi: 10.1093/jac/dkh089. [PMID: 14729746]
  • Kiyohito Ishikawa, Shinzaburo Miyakawa, Toshiyuki Tanaka, Yorio Naide, Ryoichi Shiroki, Kiyotaka Hoshinaga. [The trend and susceptibility to antibacterial agents of enterococcus species from urinary tract infections]. Nihon Hinyokika Gakkai zasshi. The japanese journal of urology. 2004 Jan; 95(1):25-34. doi: 10.5980/jpnjurol1989.95.25. [PMID: 14978938]
  • Masayuki Furuhata, Masatsugu Iwamura, Shiro Baba, Matsuhisa Inoue. Combined effect of clarithromycin and imipenem/cilastatin against urinary biofilm infection after pyeloplasty. International journal of urology : official journal of the Japanese Urological Association. 2003 Apr; 10(4):228-30. doi: 10.1046/j.0919-8172.2003.00598.x. [PMID: 12657103]
  • Nobuhiko Nomura, Junichi Mitsuyama, Yousuke Furuta, Hisashi Yamada, Mitsunori Nakata, Toshiko Fukuda, Hiroshi Yamada, Masahiro Takahata, Shinzaburo Minami. [In vitro and in vivo antibacterial activities of pazufloxacin mesilate, a new injectable quinolone]. The Japanese journal of antibiotics. 2002 Aug; 55(4):412-39. doi: . [PMID: 12378871]
  • Atsushi Enomoto, Michio Takeda, Minoru Shimoda, Shinichi Narikawa, Yukari Kobayashi, Yasuna Kobayashi, Toshinori Yamamoto, Takashi Sekine, Seok Ho Cha, Toshimitsu Niwa, Hitoshi Endou. Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors. The Journal of pharmacology and experimental therapeutics. 2002 Jun; 301(3):797-802. doi: 10.1124/jpet.301.3.797. [PMID: 12023506]
  • F Pea, L Brollo, M Lugano, L Dal Pos, M Furlanut. Therapeutic drug monitoring-guided high teicoplanin dosage regimen required to treat a hypoalbuminemic renal transplant patient undergoing continuous venovenous hemofiltration. Therapeutic drug monitoring. 2001 Oct; 23(5):587-8. doi: 10.1097/00007691-200110000-00013. [PMID: 11591906]
  • M Takeda, S Narikawa, M Hosoyamada, S H Cha, T Sekine, H Endou. Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters. European journal of pharmacology. 2001 May; 419(2-3):113-20. doi: 10.1016/s0014-2999(01)00962-1. [PMID: 11426832]
  • C Feldman, H White, J O'Grady, A Flitcroft, A Briggs, G Richards. An open, randomised, multi-centre study comparing the safety and efficacy of sitafloxacin and imipenem/cilastatin in the intravenous treatment of hospitalised patients with pneumonia. International journal of antimicrobial agents. 2001 Mar; 17(3):177-88. doi: 10.1016/s0924-8579(00)00344-7. [PMID: 11282262]
  • H Wang, Y Peng, G Xiao. [Study on the pharmacokinetics of Imipenem cilastatin in burn patients during the acute phase]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns. 2000 Dec; 16(6):349-51. doi: NULL. [PMID: 11876899]
  • Vernon T Cannon, Delon W Barfuss, Rudolfs K Zalups. Molecular homology and the luminal transport of Hg2+ in the renal proximal tubule. Journal of the American Society of Nephrology : JASN. 2000 Mar; 11(3):394-402. doi: 10.1681/asn.v113394. [PMID: 10703663]
  • C Rosman, G J Westerveld, K Kooi, R P Bleichrodt. Local treatment of generalised peritonitis in rats; effects on bacteria, endotoxin and mortality. The European journal of surgery = Acta chirurgica. 1999 Nov; 165(11):1072-9. doi: 10.1080/110241599750007928. [PMID: 10595613]
  • T Yousif, S Pooyeh, J Hannemann, J Baumann, R Tauber, K Baumann. Nephrotoxic and peroxidative potential of meropenem and imipenem/cilastatin in rat and human renal cortical slices and microsomes. International journal of clinical pharmacology and therapeutics. 1999 Oct; 37(10):475-86. doi: NULL. [PMID: 10543314]
  • S H Kim, J W Kwon, W B Kim, M G Lee. Effects of cilastatin on the pharmacokinetics of a new carbapenem, DA-1131, in rats, rabbits, and dogs. Antimicrobial agents and chemotherapy. 1999 Oct; 43(10):2524-7. doi: 10.1128/aac.43.10.2524. [PMID: 10508037]
  • E J Ernst, S Hashimoto, J Guglielmo, T Sawa, J F Pittet, H Kropp, J J Jackson, J P Wiener-Kronish. Effects of antibiotic therapy on Pseudomonas aeruginosa-induced lung injury in a rat model. Antimicrobial agents and chemotherapy. 1999 Oct; 43(10):2389-94. doi: 10.1128/aac.43.10.2389. [PMID: 10508012]
  • Y Kera, Z Liu, T Matsumoto, Y Sorimachi, H Nagasaki, R H Yamada. Rat and human membrane dipeptidase: tissue distribution and developmental changes. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 1999 May; 123(1):53-8. doi: 10.1016/s0305-0491(99)00039-5. [PMID: 10425712]
  • M L Steinhauser, C M Hogaboam, N W Lukacs, R M Strieter, S L Kunkel. Multiple roles for IL-12 in a model of acute septic peritonitis. Journal of immunology (Baltimore, Md. : 1950). 1999 May; 162(9):5437-43. doi: NULL. [PMID: 10228022]
  • T Nakamura, T Kokuryo, Y Hashimoto, K I Inui. Effects of fosfomycin and imipenem-cilastatin on the nephrotoxicity of vancomycin and cisplatin in rats. The Journal of pharmacy and pharmacology. 1999 Feb; 51(2):227-32. doi: 10.1211/0022357991772187. [PMID: 10217324]
  • M Rivera, M Crespo, J L Teruel, R Marcén, J Ortuño. Neurotoxicity due to imipenem/cilastatin in patients on continuous ambulatory peritoneal dialysis. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 1999 Jan; 14(1):258-9. doi: 10.1093/ndt/14.1.258. [PMID: 10052540]
  • M Böswald, C Döbig, C Kändler, C Krüger, J Scharf, F Soergel, S Zink, J P Guggenbichler. Pharmacokinetic and clinical evaluation of serious infections in premature and newborn infants under therapy with imipenem/cilastatin. Infection. 1999; 27(4-5):299-304. doi: NULL. [PMID: 10885853]
  • M Kusama, K Yamamoto, H Yamada, H Kotaki, H Sato, T Iga. Effect of cilastatin on renal handling of vancomycin in rats. Journal of pharmaceutical sciences. 1998 Sep; 87(9):1173-6. doi: 10.1021/js9801135. [PMID: 9724573]
  • M Carmellini, E Matteucci, U Boggi, S Cecconi, O Giampietro, F Mosca. Imipenem/cilastatin reduces cyclosporin-induced tubular damage in kidney transplant recipients. Transplantation proceedings. 1998 Aug; 30(5):2034-5. doi: 10.1016/s0041-1345(98)00523-5. [PMID: 9723380]
  • T Nakamura, Y Hashimoto, T Kokuryo, K I Inui. Effects of fosfomycin and imipenem/cilastatin on nephrotoxicity and renal excretion of vancomycin in rats. Pharmaceutical research. 1998 May; 15(5):734-8. doi: 10.1023/a:1011971019868. [PMID: 9619782]
  • M Norimatsu, D C Morrison. Correlation of antibiotic-induced endotoxin release and cytokine production in Escherichia coli-inoculated mouse whole blood ex vivo. The Journal of infectious diseases. 1998 May; 177(5):1302-7. doi: 10.1086/515291. [PMID: 9593016]
  • S E Wilson, K Faulkner. Impact an anatomical site on bacteriological and clinical outcome in the management of intra-abdominal infections. The American surgeon. 1998 May; 64(5):402-7. doi: NULL. [PMID: 9585772]
  • M A Shapiro, J C Sesnie, T M Desaty, T J Griffin, C L Heifetz. Comparative therapeutic efficacy of clinafloxacin in a Pseudomonas aeruginosa mouse renal abscess model. The Journal of antimicrobial chemotherapy. 1998 Mar; 41(3):403-5. doi: 10.1093/jac/41.3.403. [PMID: 9578169]
  • R Oral, M Akisü, N Kültürsay, F Vardar, N Tansuğ. Neonatal Klebsiella pneumonia sepsis and imipenem/cilastatin. Indian journal of pediatrics. 1998 Jan; 65(1):121-9. doi: 10.1007/bf02849703. [PMID: 10771955]
  • I Tegeder, F Bremer, R Oelkers, H Schobel, J Schüttler, K Brune, G Geisslinger. Pharmacokinetics of imipenem-cilastatin in critically ill patients undergoing continuous venovenous hemofiltration. Antimicrobial agents and chemotherapy. 1997 Dec; 41(12):2640-5. doi: 10.1128/aac.41.12.2640. [PMID: 9420033]
  • M Lizasoaín, A R Noriega. [Tolerance and safety of carbapenems: the use of meropenem]. Enfermedades infecciosas y microbiologia clinica. 1997 Sep; 15 Suppl 1(?):73-7. doi: NULL. [PMID: 9410074]
  • T Toyoguchi, S Takahashi, J Hosoya, Y Nakagawa, H Watanabe. Nephrotoxicity of vancomycin and drug interaction study with cilastatin in rabbits. Antimicrobial agents and chemotherapy. 1997 Sep; 41(9):1985-90. doi: 10.1128/aac.41.9.1985. [PMID: 9303398]
  • S Keynan, N M Hooper, A J Turner. Identification by site-directed mutagenesis of three essential histidine residues in membrane dipeptidase, a novel mammalian zinc peptidase. The Biochemical journal. 1997 Aug; 326 ( Pt 1)(?):47-51. doi: 10.1042/bj3260047. [PMID: 9337849]
  • M Carmellini, F Frosini, F Filipponi, U Boggi, F Mosca. Effect of cilastatin on cyclosporine-induced acute nephrotoxicity in kidney transplant recipients. Transplantation. 1997 Jul; 64(1):164-6. doi: 10.1097/00007890-199707150-00029. [PMID: 9233719]
  • H Tsuji, E Takazakura. [Legionella pneumonia successfully treated despite late diagnosis]. Nihon Kyobu Shikkan Gakkai zasshi. 1997 May; 35(5):566-70. doi: NULL. [PMID: 9234637]
  • Y S Moon, K C Chung, M A Gill. Pharmacokinetics of meropenem in animals, healthy volunteers, and patients. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 1997 Feb; 24 Suppl 2(?):S249-55. doi: 10.1093/clinids/24.supplement_2.s249. [PMID: 9126700]