Cilastatin (BioDeep_00000002152)
Secondary id: BioDeep_00000397743
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
(Z)-7-((R)-2-Amino-2-carboxy-ethylsulphanyl)-2-[((S)-2,2-dimethyl-cyclopropanecarbonyl)-amino]-hept-2-enoic acid
化学式: C16H26N2O5S (358.1562)
中文名称: 西司他丁
谱图信息:
最多检出来源 Viridiplantae(plant) 16.75%
分子结构信息
SMILES: CC1(C)CC1C(=O)NC(=CCCCCSCC(N)C(=O)O)C(=O)O
InChI: InChI=1S/C16H26N2O5S/c1-16(2)8-10(16)13(19)18-12(15(22)23)6-4-3-5-7-24-9-11(17)14(20)21/h6,10-11H,3-5,7-9,17H2,1-2H3,(H,18,19)(H,20,21)(H,22,23)/b12-6-/t10-,11+/m1/s1
描述信息
A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, imipenem, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4. [PubChem]
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor
CONFIDENCE standard compound; INTERNAL_ID 2129
同义名列表
21 个代谢物同义名
(Z)-7-((R)-2-Amino-2-carboxy-ethylsulphanyl)-2-[((S)-2,2-dimethyl-cyclopropanecarbonyl)-amino]-hept-2-enoic acid; (Z)-7-((R)-2-Amino-2-carboxy-ethylsulfanyl)-2-[((S)-2,2-dimethyl-cyclopropanecarbonyl)-amino]-hept-2-enoic acid; (Z)-7-((R)-2-Amino-2-carboxy-ethylsulphanyl)-2-[((S)-2,2-dimethyl-cyclopropanecarbonyl)-amino]-hept-2-enoate; (2Z)-7-{[(2R)-2-amino-2-carboxyethyl]sulfanyl}-2-{[(1S)-2,2-dimethylcyclopropyl]formamido}hept-2-enoic acid; (Z)-7-((R)-2-Amino-2-carboxy-ethylsulfanyl)-2-[((S)-2,2-dimethyl-cyclopropanecarbonyl)-amino]-hept-2-enoate; (L)-7-(2-Amino-2-carboxy-ethylsulphanyl)-2-[(2,2-dimethyl-cyclopropanecarbonyl)-amino]-hept-2-enoic acid; (L)-7-(2-Amino-2-carboxy-ethylsulfanyl)-2-[(2,2-dimethyl-cyclopropanecarbonyl)-amino]-hept-2-enoic acid; (L)-7-(2-Amino-2-carboxy-ethylsulphanyl)-2-[(2,2-dimethyl-cyclopropanecarbonyl)-amino]-hept-2-enoate; (L)-7-(2-Amino-2-carboxy-ethylsulfanyl)-2-[(2,2-dimethyl-cyclopropanecarbonyl)-amino]-hept-2-enoate; (Z)-(S)-6-Carboxy-6-[(S)-2,2-dimethylcyclopropanecarboxamido]hex-5-enyl-L-cysteine; Monosodium salt, cilastatin; Salt, cilastatin monosodium; Cilastatin monosodium salt; Sodium, cilastatin; Cilastatin Sodium; Cilastatinum; Cilastatina; Cilastatine; Cilastatin; MK0791; Cilastatin
数据库引用编号
30 个数据库交叉引用编号
- ChEBI: CHEBI:3697
- KEGG: C01675
- KEGGdrug: D07698
- PubChem: 6435415
- PubChem: 104867
- HMDB: HMDB0015535
- Metlin: METLIN785
- DrugBank: DB01597
- ChEMBL: CHEMBL766
- Wikipedia: Cilastatin
- MeSH: Cilastatin
- chemspider: 4940183
- CAS: 82009-34-5
- CAS: 81129-83-1
- MoNA: AU212930
- MoNA: AU212952
- MoNA: AU212951
- MoNA: AU212904
- MoNA: AU212933
- MoNA: AU212903
- MoNA: AU212932
- MoNA: AU212901
- MoNA: AU212902
- MoNA: AU212934
- PMhub: MS000001981
- PubChem: 4819
- PDB-CCD: CIL
- NIKKAJI: J32.849I
- RefMet: Cilastatin
- KNApSAcK: 3697
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 7461 - Apis cerana: 10.1371/JOURNAL.PONE.0175573
- 9606 - Homo sapiens: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Fan Wu, Ting Zhao, Yu Zhang, Yan Wang, Guoxin Liao, Baojing Zhang, Chao Wang, Xiangge Tian, Lei Feng, Bangjiang Fang, Xiaokui Huo, Xiaochi Ma. Beneficial herb-drug interaction of rhein in Jinhongtang and Imipenem/Cilastatin mediated by organic anion transporters.
Journal of ethnopharmacology.
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Cells.
2022 05; 11(9):. doi:
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International journal of molecular sciences.
2021 Nov; 22(22):. doi:
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Journal of the American Society of Nephrology : JASN.
2021 10; 32(10):2579-2594. doi:
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European review for medical and pharmacological sciences.
2021 Sep; 25(17):5436-5447. doi:
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