Paliperidone (BioDeep_00000397505)
Main id: BioDeep_00000002764
natural product PANOMIX_OTCML-2023
代谢物信息卡片
Paliperidone (Invega)
化学式: C23H27FN4O3 (426.2067)
中文名称: 帕利哌酮
谱图信息:
最多检出来源 Homo sapiens(urine) 62.78%
分子结构信息
SMILES: C1(=C(C(N2C(=N1)[C@@](CCC2)(O)[H])=O)CCN3CCC(CC3)C4C5=C(ON=4)C=C(C=C5)F)C
InChI: InChI=1S/C23H27FN4O3/c1-14-17(23(30)28-9-2-3-19(29)22(28)25-14)8-12-27-10-6-15(7-11-27)21-18-5-4-16(24)13-20(18)31-26-21/h4-5,13,15,19,29H,2-3,6-12H2,1H3
描述信息
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C66883 - Dopamine Antagonist
N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics
CONFIDENCE standard compound; INTERNAL_ID 1568
Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia[1].
Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia[1].
同义名列表
数据库引用编号
20 个数据库交叉引用编号
- ChEBI: CHEBI:83804
- ChEBI: CHEBI:82978
- KEGG: C21516
- KEGGdrug: D05339
- PubChem: 115237
- Metlin: METLIN2349
- DrugBank: DB01267
- ChEMBL: CHEMBL1621
- MeSH: Paliperidone Palmitate
- CAS: 144598-75-4
- MoNA: CCMSLIB00000078258
- MoNA: CCMSLIB00000078257
- MoNA: AU156805
- MoNA: AU156804
- MoNA: AU156803
- MoNA: AU156802
- MoNA: AU156801
- PubChem: 336445154
- RefMet: Paliperidone
- medchemexpress: HY-A0019
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Sergej Nadalin, Lena Zatković, Vjekoslav Peitl, Dalibor Karlović, Maja Vilibić, Ante Silić, Sanja Dević Pavlić, Alena Buretić-Tomljanović. An association between PPARα-L162V polymorphism and increased plasma LDL cholesterol levels after risperidone treatment.
Prostaglandins, leukotrienes, and essential fatty acids.
2024 Jan; 200(?):102604. doi:
10.1016/j.plefa.2023.102604. [PMID: 38113727] - Saleha Rehman, Bushra Nabi, Amaan Javed, Tahira Khan, Ashif Iqubal, Mohammad Javed Ansari, Sanjula Baboota, Javed Ali. Unraveling enhanced brain delivery of paliperidone-loaded lipid nanoconstructs: pharmacokinetic, behavioral, biochemical, and histological aspects.
Drug delivery.
2022 Dec; 29(1):1409-1422. doi:
10.1080/10717544.2022.2069880. [PMID: 35532148] - Chih-Chiang Chiu, Chun Lin, Wen-Yin Chen, Chia-Ru Chen, Shih-Ku Lin. Therapeutic Drug Monitoring of Paliperidone in Patients With Schizophrenia in Taiwan.
Journal of clinical psychopharmacology.
2022 Jul; 42(4):405-407. doi:
10.1097/jcp.0000000000001566. [PMID: 35703266] - Theocharis Chr Kyziridis. [Clinical pharmacokinetics and pharmaceutical forms of long-acting injectable antipsychotics].
Psychiatrike = Psychiatriki.
2022 Jun; 33(2):139-148. doi:
10.22365/jpsych.2021.035. [PMID: 34390562] - R Taurines, S Fekete, A Preuss-Wiedenhoff, A Warnke, C Wewetzer, P Plener, R Burger, M Gerlach, M Romanos, K M Egberts. Therapeutic drug monitoring in children and adolescents with schizophrenia and other psychotic disorders using risperidone.
Journal of neural transmission (Vienna, Austria : 1996).
2022 06; 129(5-6):689-701. doi:
10.1007/s00702-022-02485-6. [PMID: 35303169] - Jose de Leon. Precision psychiatry: The complexity of personalizing antipsychotic dosing.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2022 05; 58(?):80-85. doi:
10.1016/j.euroneuro.2022.03.001. [PMID: 35314415] - Sheldon H Preskorn. How Loading Dose Strategies for Depot Paliperidone Can Go Wrong.
Journal of psychiatric practice.
2022 Mar; 28(2):130-137. doi:
10.1097/pra.0000000000000615. [PMID: 35238824] - Georgios Schoretsanitis, Ekkehard Haen, Daria Piacentino, Andreas Conca, Katharina Endres, Christoph Hiemke, Gerhard Gründer, Michael Paulzen. Effects of body weight, smoking status, and sex on plasma concentrations of once-monthly paliperidone palmitate.
Expert review of clinical pharmacology.
2022 Feb; 15(2):243-249. doi:
10.1080/17512433.2022.2020641. [PMID: 34918984] - L A Burygina, S A Golubev, A Yu Berezantsev, E A Shumakova. [Transfer from paliperidone of one-month action to paliperidone of three-month action in schizophrenia spectrum disorders: clinical aspects, pharmacological strategies, therapeutic prediction].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova.
2022; 122(1. Vyp. 2):13-19. doi:
10.17116/jnevro202212201213. [PMID: 35238506] - Massimo Carlo Mauri, Gemma Franco, Alessandro Minutillo, Silvia Paletta, Chiara Di Pace, Alessandra Reggiori, Sara Baldelli, Dario Cattaneo. The Switch From Paliperidone Long-Acting Injectable 1- to 3-Monthly: Clinical Pharmacokinetic Evaluation in Patients With Schizophrenia (Preliminary Data).
Journal of clinical psychopharmacology.
2022 Jan; 42(1):23-30. doi:
10.1097/jcp.0000000000001484. [PMID: 34840286] - Georgios Schoretsanitis, Ekkehard Haen, Daria Piacentino, Andreas Conca, Katharina Endres, Fabio Carpi, Christoph Hiemke, Gerhard Gründer, Michael Paulzen. Pharmacokinetic Correlates of Once-Monthly Paliperidone Palmitate-Related Adverse Drug Reactions.
Clinical pharmacokinetics.
2021 12; 60(12):1583-1589. doi:
10.1007/s40262-021-01044-8. [PMID: 34142360] - Stephanie B Wheeler, Lisa P Spees, Bradford E Jackson, Christopher D Baggett, Lauren E Wilson, Melissa A Greiner, Deborah R Kaye, Tian Zhang, Daniel George, Charles D Scales, Jessica E Pritchard, Michaela A Dinan. Patterns and Predictors of Oral Anticancer Agent Use in Diverse Patients With Metastatic Renal Cell Carcinoma.
JCO oncology practice.
2021 12; 17(12):e1895-e1904. doi:
10.1200/op.20.01082. [PMID: 34138665] - Georgios Schoretsanitis, Ekkehard Haen, Daria Piacentino, Andreas Conca, Katharina Endres, Christoph Hiemke, Gerhard Gründer, Michael Paulzen. Clinical response in patients treated with once-monthly paliperidone palmitate: analysis of a therapeutic drug monitoring (TDM) database.
European archives of psychiatry and clinical neuroscience.
2021 Dec; 271(8):1437-1443. doi:
10.1007/s00406-021-01257-9. [PMID: 33821323] - Lorenzo Cellini, Domenico De Donatis, Laura Mercolini, Fabio Panariello, Diana De Ronchi, Alessandro Serretti, Andreas Conca, Davide Gaspari, Giancarlo Giupponi, Gerald Zernig, Vincenzo Florio. Switch to 3-Month Long-Acting Injectable Paliperidone May Decrease Plasma Levels: A Case Series.
Journal of clinical psychopharmacology.
2021 Nov; 41(6):694-696. doi:
10.1097/jcp.0000000000001461. [PMID: 34735103] - Eduard Trenkenschuh, Ula Savšek, Wolfgang Friess. Formulation, process, and storage strategies for lyophilizates of lipophilic nanoparticulate systems established based on the two models paliperidone palmitate and solid lipid nanoparticles.
International journal of pharmaceutics.
2021 Sep; 606(?):120929. doi:
10.1016/j.ijpharm.2021.120929. [PMID: 34303819] - Minami Tasaki, Norio Yasui-Furukori, Saaya Yokoyama, Masataka Shinozaki, Norio Sugawara, Kazutaka Shimoda. Hypoprolactinemia and hyperprolactinemia in male schizophrenia patients treated with aripiprazole and risperidone and their relationships with testosterone levels.
Neuropsychopharmacology reports.
2021 09; 41(3):379-384. doi:
10.1002/npr2.12190. [PMID: 34189861] - D Boels, J Mahé, A Olry, A Citterio-Quentin, J Moragny, P Jolliet. Fatal and life-threatening ADRs associated with paliperidone palmitate: an observational study in the French pharmacovigilance database.
Clinical toxicology (Philadelphia, Pa.).
2021 Sep; 59(9):786-793. doi:
10.1080/15563650.2021.1878206. [PMID: 33555955] - Deanna L Kelly, Amy Claxton, Ilda Bidollari, Yangchun Du. Analysis of prolactin and sexual side effects in patients with schizophrenia who switched from paliperidone palmitate to aripiprazole lauroxil.
Psychiatry research.
2021 08; 302(?):114030. doi:
10.1016/j.psychres.2021.114030. [PMID: 34118485] - Shilpa Raval, Parva Jani, Pravin Patil, Parth Thakkar, Krutika Sawant. Enhancement of bioavailability through transdermal drug delivery of paliperidone palmitate-loaded nanostructured lipid carriers.
Therapeutic delivery.
2021 08; 12(8):583-596. doi:
10.4155/tde-2021-0036. [PMID: 34286598] - Marit Tveito, Gudrun Høiseth, Tore Haslemo, Espen Molden, Robert Løvsletten Smith. Impact of age and gender on paliperidone exposure in patients after administration of long-acting injectable formulations-an observational study using blood samples from 1223 patients.
European journal of clinical pharmacology.
2021 Aug; 77(8):1201-1208. doi:
10.1007/s00228-021-03114-z. [PMID: 33616704] - Beate Klein, Christoph Silberbauer. [Rhabdomyolysis induced by paliperidone palmitate].
Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater.
2021 Jun; 35(2):98-101. doi:
10.1007/s40211-020-00377-3. [PMID: 33242202] - Stefanie Fekete, Maike Scherf-Clavel, Manfred Gerlach, Marcel Romanos, Sarah Kittel-Schneider, Stefan Unterecker, Karin Egberts. Dose-Corrected Serum Concentrations and Metabolite to Parent Compound Ratios of Venlafaxine and Risperidone from Childhood to Old Age.
Pharmacopsychiatry.
2021 May; 54(3):117-125. doi:
10.1055/a-1302-8108. [PMID: 33291155] - Sanne Maartje Kloosterboer, Brenda C M de Winter, Catrien G Reichart, Mirjam E J Kouijzer, Matthias M J de Kroon, Emma van Daalen, Wietske A Ester, Rob Rieken, Gwen C Dieleman, Daphne van Altena, Beatrijs Bartelds, Ron H N van Schaik, Kazem Nasserinejad, Manon H J Hillegers, Teun van Gelder, Bram Dierckx, Birgit C P Koch. Risperidone plasma concentrations are associated with side effects and effectiveness in children and adolescents with autism spectrum disorder.
British journal of clinical pharmacology.
2021 03; 87(3):1069-1081. doi:
10.1111/bcp.14465. [PMID: 32643213] - Yaowaluck Hongkaew, Andrea Gaedigk, Bob Wilffert, Nattawat Ngamsamut, Wiranpat Kittitharaphan, Penkhae Limsila, Chonlaphat Sukasem. Relationship between CYP2D6 genotype, activity score and phenotype in a pediatric Thai population treated with risperidone.
Scientific reports.
2021 02; 11(1):4158. doi:
10.1038/s41598-021-83570-w. [PMID: 33603025] - Jinjun Lu, Ye Yang, Jian Lu, Zuqing Wang, Yiping He, Yeliang Yan, Kai Fu, Wenjuan Jiang, Yunqing Xu, Renrong Wu, Wenqing Liu, Jingping Zhao. Effect of CYP2D6 polymorphisms on plasma concentration and therapeutic effect of risperidone.
BMC psychiatry.
2021 02; 21(1):70. doi:
10.1186/s12888-020-03034-9. [PMID: 33535976] - Saleha Rehman, Bushra Nabi, Sanjula Baboota, Javed Ali. Tailoring lipid nanoconstructs for the oral delivery of paliperidone: Formulation, optimization and in vitro evaluation.
Chemistry and physics of lipids.
2021 01; 234(?):105005. doi:
10.1016/j.chemphyslip.2020.105005. [PMID: 33144070] - Georgios Schoretsanitis, Ekkehard Haen, Andreas Conca, Daria Piacentino, Florian Ridders, Christoph Hiemke, Gerhard Gründer, Michael Paulzen. Lack of Smoking Effects on Pharmacokinetics of Oral Paliperidone-analysis of a Naturalistic Therapeutic Drug Monitoring Sample.
Pharmacopsychiatry.
2021 Jan; 54(1):31-35. doi:
10.1055/a-1221-5293. [PMID: 32767297] - Heidi N Boyda, Ric M Procyshyn, Lurdes Tse, Jessica W Y Yuen, William G Honer, Alasdair M Barr. A comparison of the metabolic side-effects of the second-generation antipsychotic drugs risperidone and paliperidone in animal models.
PloS one.
2021; 16(1):e0246211. doi:
10.1371/journal.pone.0246211. [PMID: 33508013] - Congchong Wu, Jianbo Lai, Suili Ma, Manli Huang, Shaohua Hu, Yi Xu. Paliperidone-Related Sudden Elevation of Plasma D-Dimer Levels: A Case Report.
Journal of clinical psychopharmacology.
2020 Sep; 40(5):506-507. doi:
10.1097/jcp.0000000000001249. [PMID: 32826483] - Xianyu Fan, Ji Li, Shengyuan Wu, Jingjing Jiang, Jiajing Wang, Shuowen Wang, Yuefen Lou, Guorong Fan. Field-amplified sample injection in capillary zone electrophoresis for the pharmacokinetic research of trace risperidone and its major metabolite 9-hydroxyrisperidone in beagle dogs.
Journal of separation science.
2020 Sep; 43(17):3555-3564. doi:
10.1002/jssc.202000252. [PMID: 32573947] - Massimo Carlo Mauri, Alessandra Reggiori, Alessandro Minutillo, Gemma Franco, Chiara Di Pace, Silvia Paletta, Dario Cattaneo. Paliperidone LAI and Aripiprazole LAI Plasma Level Monitoring in the Prophylaxis of Bipolar Disorder Type I with Manic Predominance.
Pharmacopsychiatry.
2020 Sep; 53(5):209-219. doi:
10.1055/a-1113-7862. [PMID: 32155657] - Jessenia Morillo-González, Daniel Hernández-Huerta, Adislen Guillama-Henríquez, Andrés Correa-Palacio, Pablo Pereira-Nogueira. Beyond the Respiratory System: A Case Report Highlighting the Impact of COVID-19 in Mental Illness and Its Physical Consequences.
The Journal of clinical psychiatry.
2020 06; 81(4):. doi:
10.4088/jcp.20l13465. [PMID: 32558406] - N Bouaziz, H Ben Rejeb, S Ateb, T Fourati, F Chammas, D Baha, R Rosetti, K Kalalou, G Saba, R Benadhira, D Januel. [Thoughts on a favourable evolution of a COVID-19 in a patient with resistant schizophrenia and on a combination of clozapine and paliperidone palmitate].
L'Encephale.
2020 Jun; 46(3S):S126-S127. doi:
10.1016/j.encep.2020.05.009. [PMID: 32475694] - Lisa Alina Kneller, Georg Hempel. Modelling Age-Related Changes in the Pharmacokinetics of Risperidone and 9-Hydroxyrisperidone in Different CYP2D6 Phenotypes Using a Physiologically Based Pharmacokinetic Approach.
Pharmaceutical research.
2020 May; 37(6):110. doi:
10.1007/s11095-020-02843-7. [PMID: 32476097] - Preeti Gupta, Banalata Mohanty. Atypical antipsychotic drug modulates early life infection induced impairment of hypothalamic-pituitary-adrenal axis: An age related study in mice.
European journal of pharmacology.
2020 Apr; 872(?):172978. doi:
10.1016/j.ejphar.2020.172978. [PMID: 32014487] - Hiroko Shimizu, Martine Neyens, Marc De Meulder, Srihari Gopal, Yuko Tsukamoto, Mahesh N Samtani, Bart Remmerie. Population Pharmacokinetics of Paliperidone Palmitate (Once-Monthly Formulation) in Japanese, Korean, and Taiwanese Patients With Schizophrenia.
Clinical pharmacology in drug development.
2020 02; 9(2):224-234. doi:
10.1002/cpdd.737. [PMID: 31876117] - Lisa Alina Kneller, Francisco Abad-Santos, Georg Hempel. Physiologically Based Pharmacokinetic Modelling to Describe the Pharmacokinetics of Risperidone and 9-Hydroxyrisperidone According to Cytochrome P450 2D6 Phenotypes.
Clinical pharmacokinetics.
2020 01; 59(1):51-65. doi:
10.1007/s40262-019-00793-x. [PMID: 31359271] - Philipp Gründer, Marc Augustin, Michael Paulzen, Gerhard Gründer. Influence of Kidney Function on Serum Risperidone Concentrations in Patients Treated With Risperidone.
The Journal of clinical psychiatry.
2019 11; 80(6):. doi:
10.4088/jcp.19m12890. [PMID: 31774943] - Alberto Russu, Adam Savitz, Maju Mathews, Srihari Gopal, Yu Feng, Mahesh N Samtani. Pharmacokinetic-Pharmacodynamic Characterization of Relapse Risk for Paliperidone Palmitate 1-Month and 3-Month Formulations.
Journal of clinical psychopharmacology.
2019 Nov; 39(6):567-574. doi:
10.1097/jcp.0000000000001137. [PMID: 31688450] - José María Bonete Llácer, Alicia Martínez Hortelano, Begoña Richart Albelda. Hyperprolactinemia in psychotic patients treated in monotherapy with long-acting injectable antipsychotics.
International journal of psychiatry in clinical practice.
2019 Sep; 23(3):189-193. doi:
10.1080/13651501.2019.1576905. [PMID: 30848967] - Suzanne J Dilly, George S Morris, Paul C Taylor, Frederic Parmentier, Coralie Williams, Mohammad Afshar. Clinical Pharmacokinetics of a Lipid-Based Formulation of Risperidone, VAL401: Analysis of a Single Dose in an Open-Label Trial of Late-Stage Cancer Patients.
European journal of drug metabolism and pharmacokinetics.
2019 Aug; 44(4):557-565. doi:
10.1007/s13318-018-00538-4. [PMID: 30628010] - Johan Y Cohen, Ariane Dumoulin-Charette, Nafaa Meraabi, Raphaël Poirier. Serum Concentration of Paliperidone Palmitate Administered Every 3 Weeks.
Psychopharmacology bulletin.
2019 06; 49(2):57-62. doi:
NULL. [PMID: 31308584] - Yin Cheong Wong, Maddalena Centanni, Elizabeth C M de Lange. Physiologically Based Modeling Approach to Predict Dopamine D2 Receptor Occupancy of Antipsychotics in Brain: Translation From Rat to Human.
Journal of clinical pharmacology.
2019 05; 59(5):731-747. doi:
10.1002/jcph.1365. [PMID: 30676661] - Harilal Patel, Prakash Patel, Nirav Modi, Pinakin Patel, Yogesh Wagh, Alex George, Nirmal Desai, Nuggehally R Srinivas. Rats and rabbits as pharmacokinetic screening tools for long acting intramuscular depots: case study with paliperidone palmitate suspension.
Xenobiotica; the fate of foreign compounds in biological systems.
2019 Apr; 49(4):415-421. doi:
10.1080/00498254.2018.1464683. [PMID: 29642738] - Maike Scherf-Clavel, Lydia Samanski, Leif G Hommers, Jürgen Deckert, Andreas Menke, Stefan Unterecker. Analysis of smoking behavior on the pharmacokinetics of antidepressants and antipsychotics: evidence for the role of alternative pathways apart from CYP1A2.
International clinical psychopharmacology.
2019 03; 34(2):93-100. doi:
10.1097/yic.0000000000000250. [PMID: 30557209] - N V Baymeeva, A I Platova, V G Kaleda, I I Miroshnichenko. [Therapeutic drug monitoring of risperidone and its active metabolite 9-hydroxyrisperidone in the treatment of schizophrenia].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova.
2019; 119(3):24-28. doi:
10.17116/jnevro201911903124. [PMID: 31089091] - Ric M Procyshyn, Joel W Lamoure, Martin A Katzman, Pamela L Skinner, Stephen E Sherman. Need for Bioequivalence Standards that Reflect the Clinical Importance of the Complex Pharmacokinetics of Paliperidone Palmitate Long-Acting Injectable Suspension.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.
2019; 22(1):548-566. doi:
10.18433/jpps30669. [PMID: 31730504] - Ana Filipce, Zorica Naumovska, Aleksandra Kapedanovska Nestorovska, Zoran Sterjev, Katerina Brezovska, Jasmina Tonic-Ribarska, Aleksandra Grozdanova, Ljubica Suturkova, Marija Raleva. Evaluation of Correlation Between the Pharmacogenetic Profiles of Risperidone Treated Psychiatry Patients with Plasma and Urine Concentration of Risperidone and its Active Moiety 9-OH Risperidone Determined with Optimized Bioanalytical LC Method.
Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki).
2018 Dec; 39(2-3):97-106. doi:
10.2478/prilozi-2018-0047. [PMID: 30864366] - Esen Gumuslu, Oguz Mutlu, Sibel Kokturk, Guner Ulak, Fatma Ceyla Eraldemir, Ozan Can Tatar, Alisan Burak Yasar, Pelin Tanyeri, Furuzan Akar, Faruk Erden. Effects of Asenapine and Paliperidone on Depression, Anxiety and Analgesy in Mice: Alterations in Brain Neurotrophic Factors, Neurogenesis, and Blood Enzyme Levels.
The Chinese journal of physiology.
2018 Oct; 61(5):280-292. doi:
10.4077/cjp.2018.bah626. [PMID: 30384401] - Rong-Qin Wu, Chong-Guang Lin, Wei Zhang, Xiao-Dong Lin, Xing-Shi Chen, Ce Chen, Li-Jun Zhang, Zi-Ye Huang, Guang-Dong Chen, Da-Li Xu, Zhi-Guang Lin, Ming-Dao Zhang. Effects of Risperidone and Paliperidone on Brain-Derived Neurotrophic Factor and N400 in First-Episode Schizophrenia.
Chinese medical journal.
2018 Oct; 131(19):2297-2301. doi:
10.4103/0366-6999.241802. [PMID: 30246715] - Nebojsa Mihajlica, Christer Betsholtz, Margareta Hammarlund-Udenaes. Pharmacokinetics of pericyte involvement in small-molecular drug transport across the blood-brain barrier.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2018 Sep; 122(?):77-84. doi:
10.1016/j.ejps.2018.06.018. [PMID: 29933077] - Hugo Geerts, Athan Spiros, Patrick Roberts, Larry Alphs. A quantitative systems pharmacology study on optimal scenarios for switching to paliperidone palmitate once-monthly.
Schizophrenia research.
2018 07; 197(?):261-268. doi:
10.1016/j.schres.2017.11.016. [PMID: 29395607] - Can-Jun Ruan, Wei Guo, Miao Zhou, Gui-Xin Guo, Chuan-Yue Wang, Wen-Biao Li, Jose de Leon. Quantitative determination of risperidone, paliperidone and olanzapine in human serum by liquid chromatography-tandem mass spectrometry coupled with on-line solid-phase extraction.
Biomedical chromatography : BMC.
2018 Jul; 32(7):e4209. doi:
10.1002/bmc.4209. [PMID: 29473184] - Georgios Schoretsanitis, Jose de Leon, Francisco J Diaz. Prolactin levels: sex differences in the effects of risperidone, 9-hydroxyrisperidone levels, CYP2D6 and ABCB1 variants.
Pharmacogenomics.
2018 07; 19(10):815-823. doi:
10.2217/pgs-2018-0053. [PMID: 29914302] - Wen-Hua Ji, Yu-Shuang Guo, Xiao Wang, D-S Guo. A water-compatible magnetic molecularly imprinted polymer for the selective extraction of risperidone and 9-hydroxyrisperidone from human urine.
Talanta.
2018 May; 181(?):392-400. doi:
10.1016/j.talanta.2018.01.025. [PMID: 29426531] - Masaru Nakamura, Yasutaka Fujita, Takahiko Nagamine. Serum prolactin levels might become a useful marker for switching strategy to paliperidone palmitate in male schizophrenia patient.
Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists.
2018 03; 10(1):. doi:
10.1111/appy.12300. [PMID: 29314615] - Manli Huang, Liang Yu, Fen Pan, Shaojia Lu, Shaohua Hu, Jianbo Hu, Jinkai Chen, Pingbo Jin, Hongli Qi, Yi Xu. A randomized, 13-week study assessing the efficacy and metabolic effects of paliperidone palmitate injection and olanzapine in first-episode schizophrenia patients.
Progress in neuro-psychopharmacology & biological psychiatry.
2018 Feb; 81(?):122-130. doi:
10.1016/j.pnpbp.2017.10.021. [PMID: 29097257] - Sofia Gustafsson, Veronica Lindström, Martin Ingelsson, Margareta Hammarlund-Udenaes, Stina Syvänen. Intact blood-brain barrier transport of small molecular drugs in animal models of amyloid beta and alpha-synuclein pathology.
Neuropharmacology.
2018 Jan; 128(?):482-491. doi:
10.1016/j.neuropharm.2017.08.002. [PMID: 28797721] - Young-Chul Chung, Yin Cui, Tomiki Sumiyoshi, Min-Gul Kim, Keon-Hak Lee. Associations of fatty acids with cognition, psychopathology, and brain-derived neurotrophic factor levels in patients with first-episode schizophrenia and related disorders treated with paliperidone extended release.
Journal of psychopharmacology (Oxford, England).
2017 12; 31(12):1556-1563. doi:
10.1177/0269881117731169. [PMID: 28946784] - Amit Taneja, An Vermeulen, Dymphy R H Huntjens, Meindert Danhof, Elizabeth C M De Lange, Johannes H Proost. Modeling of prolactin response following dopamine D2 receptor antagonists in rats: can it be translated to clinical dosing?.
Pharmacology research & perspectives.
2017 12; 5(6):. doi:
10.1002/prp2.364. [PMID: 29226628] - Arne Helland, Olav Spigset. Serum Concentrations of Paliperidone After Administration of the Long-Acting Injectable Formulation.
Therapeutic drug monitoring.
2017 12; 39(6):659-662. doi:
10.1097/ftd.0000000000000457. [PMID: 29040230] - Tomoyuki Enokiya, Erquan Zhang, Kenji Ikemura, Yuichi Muraki, Yoshiaki Iwashita, Takuya Iwamoto, Hiroshi Imai, Kazuo Maruyama, Masahiro Okuda. Effect of lipid emulsion infusion on paliperidone pharmacokinetics in the acute overdose rat model: A potential emergency treatment for paliperidone intoxication.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2017 Nov; 109(?):217-222. doi:
10.1016/j.ejps.2017.08.010. [PMID: 28821438] - Georgios Schoretsanitis, Edoardo Spina, Christoph Hiemke, Jose de Leon. A systematic review and combined analysis of therapeutic drug monitoring studies for long-acting risperidone.
Expert review of clinical pharmacology.
2017 Sep; 10(9):965-981. doi:
10.1080/17512433.2017.1345623. [PMID: 28699847] - J Korell, B Green, B Remmerie, A Vermeulen. Determination of Plasma Concentration Reference Ranges for Risperidone and Paliperidone.
CPT: pharmacometrics & systems pharmacology.
2017 09; 6(9):589-595. doi:
10.1002/psp4.12217. [PMID: 28614899] - Koki Chiba, Takeshi Wada, Yuji Nakamura, Xin Cao, Mihoko Hagiwara-Nagasawa, Hiroko Izumi-Nakaseko, Kentaro Ando, Koichiro Tanaka, Atsuhiko T Naito, Atsushi Sugiyama. Analysis of proarrhythmic potential of an atypical antipsychotic drug paliperidone in the halothane-anesthetized dogs.
Journal of pharmacological sciences.
2017 Aug; 134(4):239-246. doi:
10.1016/j.jphs.2017.08.002. [PMID: 28844424] - Shao-Ting Wang, Yan Li. Development of a UPLC-MS/MS method for routine therapeutic drug monitoring of aripiprazole, amisulpride, olanzapine, paliperidone and ziprasidone with a discussion of their therapeutic reference ranges for Chinese patients.
Biomedical chromatography : BMC.
2017 Aug; 31(8):. doi:
10.1002/bmc.3928. [PMID: 28054367] - Michael Paulzen, Ekkehard Haen, Christoph Hiemke, Benedikt Stegmann, Sarah E Lammertz, Gerhard Gründer, Georgios Schoretsanitis. Cytochrome P450-mediated interaction between perazine and risperidone: implications for antipsychotic polypharmacy.
British journal of clinical pharmacology.
2017 08; 83(8):1668-1675. doi:
10.1111/bcp.13255. [PMID: 28160505] - Hala Mahmoud Helal, Sana Mohamed Mortada, Marwa Ahmed Sallam. Paliperidone-Loaded Nanolipomer System for Sustained Delivery and Enhanced Intestinal Permeation: Superiority to Polymeric and Solid Lipid Nanoparticles.
AAPS PharmSciTech.
2017 Aug; 18(6):1946-1959. doi:
10.1208/s12249-016-0657-1. [PMID: 27914041] - Vijay Ivaturi, Mathangi Gopalakrishnan, Jogarao V S Gobburu, Weiyan Zhang, Yongzhen Liu, Christian Heidbreder, Celine M Laffont. Exposure-response analysis after subcutaneous administration of RBP-7000, a once-a-month long-acting Atrigel formulation of risperidone.
British journal of clinical pharmacology.
2017 07; 83(7):1476-1498. doi:
10.1111/bcp.13246. [PMID: 28133766] - Georgios Schoretsanitis, Ekkehard Haen, Benedikt Stegmann, Christoph Hiemke, Gerhard Gründer, Michael Paulzen. Effect of smoking on risperidone pharmacokinetics - A multifactorial approach to better predict the influence on drug metabolism.
Schizophrenia research.
2017 07; 185(?):51-57. doi:
10.1016/j.schres.2016.12.016. [PMID: 27993531] - Massimo Carlo Mauri, Silvia Paletta, Chiara Di Pace, Alessandra Reggiori, Chiara Rovera, Alessio Fiorentini, Carlo Alfredo Altamura. Paliperidone Long-Acting Plasma Level Monitoring and a New Method of Evaluation of Clinical Stability.
Pharmacopsychiatry.
2017 Jul; 50(4):145-151. doi:
10.1055/s-0037-1601396. [PMID: 28278537] - Johanna Weber, Stefanie Oberfeld, Andrea Bonse, Klaus Telger, Rainer Lingg, Georg Hempel. Validation of a dried blood spot method for therapeutic drug monitoring of citalopram, mirtazapine and risperidone and its active metabolite 9-hydroxyrisperidone using HPLC-MS.
Journal of pharmaceutical and biomedical analysis.
2017 Jun; 140(?):347-354. doi:
10.1016/j.jpba.2017.02.061. [PMID: 28395245] - Steven G Potkin, Jean-Yves Loze, Carlos Forray, Ross A Baker, Christophe Sapin, Timothy Peters-Strickland, Maud Beillat, Anna-Greta Nylander, Peter Hertel, Henrik Steen Andersen, Anna Eramo, Karina Hansen, Dieter Naber. Reduced sexual dysfunction with aripiprazole once-monthly versus paliperidone palmitate: results from QUALIFY.
International clinical psychopharmacology.
2017 05; 32(3):147-154. doi:
10.1097/yic.0000000000000168. [PMID: 28252452] - Kelsey Bohn, Allison Lange, Jean Chmielewski, Christine A Hrycyna. Dual Modulation of Human P-Glycoprotein and ABCG2 with Prodrug Dimers of the Atypical Antipsychotic Agent Paliperidone in a Model of the Blood-Brain Barrier.
Molecular pharmaceutics.
2017 04; 14(4):1107-1119. doi:
10.1021/acs.molpharmaceut.6b01044. [PMID: 28264565] - Hidenobu Suzuki, Keishi Gen, Yuichi Inoue, Hiroyuki Hibino, Ayako Mikami, Hideo Matsumoto, Katsunaka Mikami. Assessments of plasma concentrations, pathology symptoms, and cognition following paliperidone treatment in schizophrenic patients previously treated with risperidone.
Asian journal of psychiatry.
2017 Apr; 26(?):56-57. doi:
10.1016/j.ajp.2017.01.005. [PMID: 28483092] - Mats O Magnusson, Mahesh N Samtani, Elodie L Plan, E Niclas Jonsson, Stefaan Rossenu, An Vermeulen, Alberto Russu. Dosing and Switching Strategies for Paliperidone Palmitate 3-Month Formulation in Patients with Schizophrenia Based on Population Pharmacokinetic Modeling and Simulation, and Clinical Trial Data.
CNS drugs.
2017 Apr; 31(4):273-288. doi:
10.1007/s40263-017-0416-1. [PMID: 28258365] - Mats O Magnusson, Mahesh N Samtani, Elodie L Plan, E Niclas Jonsson, Stefaan Rossenu, An Vermeulen, Alberto Russu. Population Pharmacokinetics of a Novel Once-Every 3 Months Intramuscular Formulation of Paliperidone Palmitate in Patients with Schizophrenia.
Clinical pharmacokinetics.
2017 04; 56(4):421-433. doi:
10.1007/s40262-016-0459-3. [PMID: 27743205] - A Carlo Altamura, Giuseppe Delvecchio, Silvia Paletta, Chiara Di Pace, Alessandra Reggiori, Alessio Fiorentini, M Donatella Mirabile, Riccardo A Paoli, Claudia Cinnante, Fabio Triulzi, Massimo C Mauri, Paolo Brambilla. Gray matter volumes may predict the clinical response to paliperidone palmitate long-acting in acute psychosis: A pilot longitudinal neuroimaging study.
Psychiatry research. Neuroimaging.
2017 Mar; 261(?):80-84. doi:
10.1016/j.pscychresns.2017.01.008. [PMID: 28161644] - Natchaya Vanwong, Nattawat Ngamsamut, Sadeep Medhasi, Apichaya Puangpetch, Montri Chamnanphon, Teerarat Tan-Kam, Yaowaluck Hongkaew, Penkhae Limsila, Chonlaphat Sukasem. Impact of CYP2D6 Polymorphism on Steady-State Plasma Levels of Risperidone and 9-Hydroxyrisperidone in Thai Children and Adolescents with Autism Spectrum Disorder.
Journal of child and adolescent psychopharmacology.
2017 03; 27(2):185-191. doi:
10.1089/cap.2014.0171. [PMID: 26780783] - Shinji Shimizu, Sandra M den Hoedt, Victor Mangas-Sanjuan, Sinziana Cristea, Jana K Geuer, Dirk-Jan van den Berg, Robin Hartman, Francisco Bellanti, Elizabeth C M de Lange. Target-Site Investigation for the Plasma Prolactin Response: Mechanism-Based Pharmacokinetic-Pharmacodynamic Analysis of Risperidone and Paliperidone in the Rat.
Drug metabolism and disposition: the biological fate of chemicals.
2017 02; 45(2):152-159. doi:
10.1124/dmd.116.072306. [PMID: 27836941] - Jinlong Zhao, Lexi Wang, Chunyu Fan, Kongtong Yu, Ximing Liu, Xiaolei Zhao, Dan Wang, Wenhua Liu, Zhengxing Su, Fengying Sun, Youxin Li. Development of near zero-order release PLGA-based microspheres of a novel antipsychotic.
International journal of pharmaceutics.
2017 Jan; 516(1-2):32-38. doi:
10.1016/j.ijpharm.2016.11.007. [PMID: 27825865] - Georgios Schoretsanitis, Ekkehard Haen, Gerhard Gründer, Benedikt Stegmann, Koen R J Schruers, Christoph Hiemke, Sarah E Lammertz, Michael Paulzen. Pharmacokinetic Drug-Drug Interactions of Mood Stabilizers and Risperidone in Patients Under Combined Treatment.
Journal of clinical psychopharmacology.
2016 Dec; 36(6):554-561. doi:
10.1097/jcp.0000000000000601. [PMID: 27811552] - Saeko Ikai, Takefumi Suzuki, Masaru Mimura, Hiroyuki Uchida. Plasma levels and estimated dopamine D2 receptor occupancy of long-acting injectable risperidone during maintenance treatment of schizophrenia: a 3-year follow-up study.
Psychopharmacology.
2016 Dec; 233(23-24):4003-4010. doi:
10.1007/s00213-016-4428-1. [PMID: 27631410] - Bart Remmerie, Marc De Meulder, Sveta Weiner, Adam Savitz. Comparison of Capillary and Venous Drug Concentrations After Administration of a Single Dose of Risperidone, Paliperidone, Quetiapine, Olanzapine, or Aripiprazole.
Clinical pharmacology in drug development.
2016 Nov; 5(6):528-537. doi:
10.1002/cpdd.290. [PMID: 27365164] - Bart Remmerie, Marc De Meulder, Jay Ariyawansa, Adam Savitz. Comparison of Capillary and Venous Plasma Drug Concentrations After Repeated Administration of Risperidone, Paliperidone, Quetiapine, Olanzapine, or Aripiprazole.
Clinical pharmacology in drug development.
2016 Nov; 5(6):538-547. doi:
10.1002/cpdd.291. [PMID: 27363344] - Natchaya Vanwong, Santirat Prommas, Apichaya Puangpetch, Yaowaluck Hongkaew, Nopadol Nuntamool, Chalitpol Na Nakorn, Nattawat Ngamsamut, Penkhae Limsila, Chonlaphat Sukasem. Development and Validation of Liquid Chromatography/Tandem Mass Spectrometry Analysis for Therapeutic Drug Monitoring of Risperidone and 9-Hydroxyrisperidone in Pediatric Patients with Autism Spectrum Disorders.
Journal of clinical laboratory analysis.
2016 Nov; 30(6):1236-1246. doi:
10.1002/jcla.22009. [PMID: 27346210] - Espen Molden, Ragnhild Birkeland Waade, Maren Hoff, Tore Haslemo. Impact of Ageing on Serum Concentrations of Risperidone and Its Active Metabolite in Patients with Known CYP2D6 Genotype.
Basic & clinical pharmacology & toxicology.
2016 Nov; 119(5):470-475. doi:
10.1111/bcpt.12614. [PMID: 27145399] - Michael Paulzen, Ekkehard Haen, Benedikt Stegmann, Christoph Hiemke, Gerhard Gründer, Sarah E Lammertz, Georgios Schoretsanitis. Body mass index (BMI) but not body weight is associated with changes in the metabolism of risperidone; A pharmacokinetics-based hypothesis.
Psychoneuroendocrinology.
2016 11; 73(?):9-15. doi:
10.1016/j.psyneuen.2016.07.009. [PMID: 27448523] - Bennett Levitan, Michael Markowitz, Ibrahim Turkoz, Dong-Jing Fu, Srihari Gopal, Larry Alphs. Benefit-risk assessment of paliperidone oral extended-release tablet versus monthly injectable for maintenance treatment of schizophrenia.
International clinical psychopharmacology.
2016 11; 31(6):315-22. doi:
10.1097/yic.0000000000000141. [PMID: 27434314] - Mahesh N Samtani, Partha Nandy, Paulien Ravenstijn, Bart Remmerie, An Vermeulen, Alberto Russu, Peter D'hoore, Ellen Z Baum, Adam Savitz, Srihari Gopal, David Hough. Prospective dose selection and acceleration of paliperidone palmitate 3-month formulation development using a pharmacometric bridging strategy.
British journal of clinical pharmacology.
2016 11; 82(5):1364-1370. doi:
10.1111/bcp.13050. [PMID: 27333588] - Georgios Schoretsanitis, Benedikt Stegmann, Christoph Hiemke, Gerhard Gründer, Koen R J Schruers, Sebastian Walther, Sarah E Lammertz, Ekkehard Haen, Michael Paulzen. Pharmacokinetic patterns of risperidone-associated adverse drug reactions.
European journal of clinical pharmacology.
2016 Sep; 72(9):1091-8. doi:
10.1007/s00228-016-2085-2. [PMID: 27376639] - Nattawat Ngamsamut, Yaowaluck Hongkaew, Natchaya Vanwong, Pornpen Srisawasdi, Apichaya Puangpetch, Bhunnada Chamkrachangpada, Theerarat Tan-Khum, Penkhae Limsila, Chonlaphat Sukasem. 9-Hydroxyrisperidone-Induced Hyperprolactinaemia in Thai Children and Adolescents with Autism Spectrum Disorder.
Basic & clinical pharmacology & toxicology.
2016 Sep; 119(3):267-72. doi:
10.1111/bcpt.12570. [PMID: 26879343] - Matteo Caloro, Giuseppa Calabrò, Georgios D Kotzalidis, Ilaria Cuomo, John M Corkery, Alessandro Emiliano Vento, Luana Lionetto, Sergio De Filippis, Valentina Ranieri, Davide Lonati, Carlo Alessandro Locatelli, Eleonora de Pisa, Antonio Di Tommaso, Paolo Girardi, Fabrizio Schifano. Use of benzylglycinamide by a HIV-seropositive polysubstance user: The changing pattern of novel psychoactive substance use among youths.
Addictive behaviors.
2016 09; 60(?):53-7. doi:
10.1016/j.addbeh.2016.03.032. [PMID: 27088514] - Yu-Han Kao, Yijuang Chern, Hui-Ting Yang, Hui-Mei Chen, Chun-Jung Lin. Regulation of P-glycoprotein expression in brain capillaries in Huntington's disease and its impact on brain availability of antipsychotic agents risperidone and paliperidone.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2016 08; 36(8):1412-23. doi:
10.1177/0271678x15606459. [PMID: 26661162] - Michael Paulzen, Ekkehard Haen, Gerhard Gründer, Sarah E Lammertz, Benedikt Stegmann, Koen Rj Schruers, Sebastian Walther, Georgios Schoretsanitis. Pharmacokinetic considerations in the treatment of hypertension in risperidone-medicated patients - thinking of clinically relevant CYP2D6 interactions.
Journal of psychopharmacology (Oxford, England).
2016 08; 30(8):803-9. doi:
10.1177/0269881116650390. [PMID: 27251417] - Young-Chul Chung, Yin Cui, Min-Gul Kim, Yun-Jeong Kim, Keon-Hak Lee, Soo-Wan Chae. Early predictors of a clinical response at 8 weeks in patients with first-episode psychosis treated with paliperidone ER.
Journal of psychopharmacology (Oxford, England).
2016 08; 30(8):810-8. doi:
10.1177/0269881116654698. [PMID: 27334812] - Bart Remmerie, Jay Ariyawansa, Marc De Meulder, Danielle Coppola, Joris Berwaerts. Drug-Drug Interaction Studies of Paliperidone and Divalproex Sodium Extended-Release Tablets in Healthy Participants and Patients with Psychiatric Disorders.
Journal of clinical pharmacology.
2016 06; 56(6):683-92. doi:
10.1002/jcph.648. [PMID: 26412032] - Young-Min Park, Seung-Hwan Lee, Bun-Hee Lee, Kyu Young Lee, Kye-Seong Lee, Seung-Gul Kang, Hwa-Young Lee, Won Kim. Prolactin and macroprolactin levels in psychiatric patients receiving atypical antipsychotics: A preliminary study.
Psychiatry research.
2016 05; 239(?):184-9. doi:
10.1016/j.psychres.2016.03.015. [PMID: 27010188] - Nicolas Darville, Marjolein van Heerden, Dirk Mariën, Marc De Meulder, Stefaan Rossenu, An Vermeulen, An Vynckier, Sandra De Jonghe, Patrick Sterkens, Pieter Annaert, Guy Van den Mooter. The effect of macrophage and angiogenesis inhibition on the drug release and absorption from an intramuscular sustained-release paliperidone palmitate suspension.
Journal of controlled release : official journal of the Controlled Release Society.
2016 05; 230(?):95-108. doi:
10.1016/j.jconrel.2016.03.041. [PMID: 27067365]
