Hemipyocyanine (BioDeep_00000003944)

   


代谢物信息卡片


1-Hydroxyphenanzine

化学式: C12H8N2O (196.0637)
中文名称: 1-羟基吩嗪
谱图信息: 最多检出来源 Homo sapiens(blood) 47.71%

分子结构信息

SMILES: C1=CC=C2C(=C1)N=C3C=CC=C(C3=N2)O
InChI: InChI=1S/C12H8N2O/c15-11-7-3-6-10-12(11)14-9-5-2-1-4-8(9)13-10/h1-7,15H

描述信息

CONFIDENCE standard compound; INTERNAL_ID 186

同义名列表

3 个代谢物同义名

1-Hydroxyphenazine; Hemipyocyanine; 1-Hydroxyphenanzine



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ALB, ALOX5, CAT, ELANE, FPR1, SERPINB1, SNCA, XDH
Peripheral membrane protein 2 ALOX5, SRL
Nucleus 4 ALB, GABPA, MPO, SNCA
cytosol 6 ALB, ALOX5, CAT, ELANE, SNCA, XDH
phagocytic vesicle 1 ELANE
centrosome 1 ALB
nucleoplasm 3 ALOX5, GABPA, MPO
Cell membrane 2 FPR1, TNF
Cell projection, axon 1 SNCA
Multi-pass membrane protein 1 FPR1
Synapse 1 SNCA
cell cortex 1 SNCA
cell surface 2 ELANE, TNF
Golgi apparatus 1 ALB
growth cone 1 SNCA
neuronal cell body 2 SNCA, TNF
postsynapse 1 SNCA
Cytoplasm, cytosol 1 ALOX5
Lysosome 2 MPO, SNCA
plasma membrane 4 FPR1, KNG1, SNCA, TNF
synaptic vesicle membrane 1 SNCA
Membrane 4 CAT, FPR1, SERPINB1, SNCA
axon 1 SNCA
extracellular exosome 7 ALB, CAT, ELANE, KNG1, LYZ, MPO, SERPINB1
endoplasmic reticulum 1 ALB
extracellular space 11 ALB, ALOX5, CXCL8, ELANE, KNG1, LYZ, MPO, SERPINB1, SNCA, TNF, XDH
perinuclear region of cytoplasm 2 ALOX5, SNCA
mitochondrion 2 CAT, SNCA
protein-containing complex 3 ALB, CAT, SNCA
intracellular membrane-bounded organelle 2 CAT, MPO
Secreted 4 ALB, CXCL8, SERPINB1, SNCA
extracellular region 11 ALB, ALOX5, CAT, CXCL8, ELANE, KNG1, LYZ, MPO, SERPINB1, SNCA, TNF
mitochondrial matrix 1 CAT
anchoring junction 1 ALB
Nucleus membrane 1 ALOX5
nuclear membrane 1 ALOX5
external side of plasma membrane 1 TNF
actin cytoskeleton 1 SNCA
Early endosome 1 SERPINB1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Cytoplasm, perinuclear region 1 ALOX5
Membrane raft 1 TNF
focal adhesion 1 CAT
Peroxisome 2 CAT, XDH
sarcoplasmic reticulum 1 XDH
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 3 ELANE, KNG1, SERPINB1
secretory granule 2 ELANE, MPO
ciliary basal body 1 ALB
chromatin 1 GABPA
phagocytic cup 1 TNF
supramolecular fiber 1 SNCA
centriole 1 ALB
cytoplasmic ribonucleoprotein granule 1 SERPINB1
Secreted, extracellular space 1 KNG1
spindle pole 1 ALB
blood microparticle 2 ALB, KNG1
nuclear envelope 1 ALOX5
Nucleus envelope 1 ALOX5
azurophil granule 1 MPO
ficolin-1-rich granule lumen 2 ALOX5, CAT
secretory granule lumen 3 ALOX5, CAT, SERPINB1
secretory granule membrane 1 FPR1
endoplasmic reticulum lumen 2 ALB, KNG1
nuclear matrix 1 ALOX5
transcription repressor complex 1 ELANE
platelet alpha granule lumen 2 ALB, KNG1
axon terminus 1 SNCA
specific granule lumen 2 ELANE, LYZ
tertiary granule lumen 1 LYZ
azurophil granule membrane 1 FPR1
azurophil granule lumen 3 ELANE, LYZ, MPO
Sarcoplasmic reticulum membrane 1 SRL
Nucleus matrix 1 ALOX5
nuclear envelope lumen 1 ALOX5
Sarcoplasmic reticulum lumen 1 SRL
phagocytic vesicle lumen 1 MPO
ficolin-1-rich granule membrane 1 FPR1
Cytoplasmic vesicle, phagosome 1 ELANE
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
inclusion body 1 SNCA
Nucleus intermembrane space 1 ALOX5
Cytolytic granule 1 SERPINB1
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Yupeng Wan, Hongchen Liu, Mo Xian, Wei Huang. Biosynthesis and metabolic engineering of 1-hydroxyphenazine in Pseudomonas chlororaphis H18. Microbial cell factories. 2021 Dec; 20(1):235. doi: 10.1186/s12934-021-01731-y. [PMID: 34965873]
  • Jun Xiao, Aye Aye Thwe, Tingting Liu, Dafei Gong, Wanhua Lin, Changhua Shang, ZuJun Lu. Anti-Inflammatory Effects of an Extract from Pseudomonas aeruginosa and Its Purified Product 1-Hydroxyphenazine on RAW264.7 Cells. Current microbiology. 2021 Jul; 78(7):2762-2773. doi: 10.1007/s00284-021-02544-3. [PMID: 34043026]
  • T T Liu, F C Ye, C P Pang, T Q Yong, W D Tang, J Xiao, C H Shang, Z J Lu. Isolation and identification of bioactive substance 1-hydroxyphenazine from Pseudomonas aeruginosa and its antimicrobial activity. Letters in applied microbiology. 2020 Sep; 71(3):303-310. doi: 10.1111/lam.13332. [PMID: 32449160]
  • Valeri V Mossine, Deborah L Chance, James K Waters, Thomas P Mawhinney. Interaction of Bacterial Phenazines with Colistimethate in Bronchial Epithelial Cells. Antimicrobial agents and chemotherapy. 2018 08; 62(8):. doi: 10.1128/aac.02349-17. [PMID: 29784845]
  • Seema Dharni, Mansoor Alam, Komal Kalani, Abdul-Khaliq, Abdul Samad, Santosh Kumar Srivastava, Dharani Dhar Patra. Production, purification, and characterization of antifungal metabolite from Pseudomonas aeruginosa SD12, a new strain obtained from tannery waste polluted soil. Journal of microbiology and biotechnology. 2012 May; 22(5):674-83. doi: 10.4014/jmb.1109.09061. [PMID: 22561863]
  • Leland S Pierson, Elizabeth A Pierson. Metabolism and function of phenazines in bacteria: impacts on the behavior of bacteria in the environment and biotechnological processes. Applied microbiology and biotechnology. 2010 May; 86(6):1659-70. doi: 10.1007/s00253-010-2509-3. [PMID: 20352425]
  • D V Mavrodi, R F Bonsall, S M Delaney, M J Soule, G Phillips, L S Thomashow. Functional analysis of genes for biosynthesis of pyocyanin and phenazine-1-carboxamide from Pseudomonas aeruginosa PAO1. Journal of bacteriology. 2001 Nov; 183(21):6454-65. doi: 10.1128/jb.183.21.6454-6465.2001. [PMID: 11591691]
  • G Ramafi, R Anderson, A Theron, C Feldman, G W Taylor, R Wilson, P J Cole. Exposure of N-formyl-L-methionyl-L-leucyl-L-phenylalanine-activated human neutrophils to the Pseudomonas aeruginosa-derived pigment 1-hydroxyphenazine is associated with impaired calcium efflux and potentiation of primary granule enzyme release. Infection and immunity. 1999 Oct; 67(10):5157-62. doi: 10.1128/iai.67.10.5157-5162.1999. [PMID: 10496890]
  • I Dormehl, G Ras, G Taylor, N Hugo. Effect of Pseudomonas aeruginosa-derived pyocyanin and 1-hydroxyphenazine on pulmonary mucociliary clearance monitored scintigraphically in the baboon model. International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology. 1991; 18(5):455-9. doi: 10.1016/0883-2897(91)90105-t. [PMID: 1917514]