Phellodendrine (BioDeep_00000000389)
PANOMIX_OTCML-2023 natural product
代谢物信息卡片
化学式: C20H24NO4+ (342.1705)
中文名称: 黄柏碱
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 63.19%
分子结构信息
SMILES: COc1cc2c(cc1O)C[C@H]1c3cc(O)c(OC)cc3CC[N@@+]1(C)C2
InChI: InChI=1S/C20H23NO4/c1-21-5-4-12-8-19(24-2)18(23)10-15(12)16(21)6-13-7-17(22)20(25-3)9-14(13)11-21/h7-10,16H,4-6,11H2,1-3H3,(H-,22,23)/p+1/t16-,21-/m0/s1
描述信息
Phellodendrine is an alkaloid.
Phellodendrine is a natural product found in Phellodendron chinense, Phellodendron chinense var. glabriusculum, and other organisms with data available.
同义名列表
13 个代谢物同义名
(7S,13aS)-3,10-dimethoxy-7-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-7-ium-2,11-diol; 6H-Dibenzo[a,g]quinolizinium, 5,8,13,13a-tetrahydro-2,11-dihydroxy-3,10-dimethoxy-7-methyl-, (7S,13aS)-; 6H-Dibenzo(a,g)quinolizinium, 5,8,13,13a-tetrahydro-2,11-dihydroxy-3,10-dimethoxy-7-methyl-, (7S-cis)-; (7S,13aS)-5,8,13,13a-Tetrahydro-2,11-dihydroxy-3,10-dimethoxy-7-methyl-6H-dibenzo[a,g]quinolizinium; N-Methylcoreximine; UNII-AR68S526RB; Phellodendrine; phallodendrin; OB-5 compound; pellodendrine; AR68S526RB; 1ST1625; Phellodendrine
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:80886
- KEGG: C17046
- PubChem: 3081405
- Wikipedia: Phellodendrine
- MeSH: phellodendrine
- ChemIDplus: 0006873138
- chemspider: 2339019
- CAS: 6873-13-8
- medchemexpress: HY-N0427
- MetaboLights: MTBLC80886
- PubChem: 96023524
- KNApSAcK: C00027160
- NIKKAJI: J476.063H
- KNApSAcK: 80886
- LOTUS: LTS0191638
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
28 个相关的物种来源信息
- 22140 - Annonaceae: LTS0191638
- 2759 - Eukaryota: LTS0191638
- 3398 - Magnoliopsida: LTS0191638
- 68553 - Phellodendron: LTS0191638
- 68554 - Phellodendron amurense:
- 68554 - Phellodendron amurense: 10.1016/0021-9673(93)83021-J
- 68554 - Phellodendron amurense: 10.1055/S-2006-957997
- 68554 - Phellodendron amurense: 10.1055/S-2006-959529
- 68554 - Phellodendron amurense: 10.1055/S-2006-959761
- 68554 - Phellodendron amurense: 10.1076/PHBI.37.1.77.6323
- 68554 - Phellodendron amurense: LTS0191638
- 354508 - Phellodendron chinense:
- 354508 - Phellodendron chinense: 10.1016/0021-9673(93)83021-J
- 354508 - Phellodendron chinense: 10.1055/S-2006-959761
- 354508 - Phellodendron chinense: LTS0191638
- 354509 - Phellodendron chinense var. glabriusculum:
- 354509 - Phellodendron chinense var. glabriusculum: 10.1016/0021-9673(93)83021-J
- 354509 - Phellodendron chinense var. glabriusculum: 10.1055/S-2006-959761
- 354509 - Phellodendron chinense var. glabriusculum: LTS0191638
- 23513 - Rutaceae: LTS0191638
- 35493 - Streptophyta: LTS0191638
- 58023 - Tracheophyta: LTS0191638
- 33090 - Viridiplantae: LTS0191638
- 225838 - Xylopia: LTS0191638
- 992813 - Xylopia parviflora: 10.1016/J.PHYTOCHEM.2003.12.010
- 992813 - Xylopia parviflora: LTS0191638
- 33090 - 关黄柏: -
- 33090 - 黄柏: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xiaoting Tian, Zhou Xu, Pei Hu, Yanyan Yu, Zhixiong Li, Yuanjie Ma, Mingcang Chen, Zhaolin Sun, Fang Liu, Jingya Li, Chenggang Huang. Determination of the antidiabetic chemical basis of Phellodendri Chinensis Cortex by integrating hepatic disposition in vivo and hepatic gluconeogenese inhibition in vitro.
Journal of ethnopharmacology.
2020 Dec; 263(?):113215. doi:
10.1016/j.jep.2020.113215. [PMID: 32768636] - Xin Dong, Juan Yang, Xiao-Ting Zheng, Yan Chen, Li-Hong Ye, Bin Wang, Hui Zheng, Jun Cao, Qiu-Yan Wang, Yu-Han Hu. Ion pair assisted micro matrix solid phase dispersion extraction of alkaloids from medical plant.
Electrophoresis.
2020 01; 41(1-2):123-130. doi:
10.1002/elps.201900244. [PMID: 31674686] - Jingyi Jin, Haoyu Xue, Xiaoshu Sun, Bin Zan, Yuanyuan Li, Tianming Wang, Rong Shi, Yueming Ma. Simultaneous determination of multiple compounds of Da-Huang-Xiao-Shi decoction in rat plasma by LC-MS/MS and its application in a pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis.
2019 Sep; 174(?):8-18. doi:
10.1016/j.jpba.2019.05.050. [PMID: 31153138] - Shu-Hui Wang, Zhe Deng, Jun Zhang, Meng-Jiao Jiao, Guo-Yuan Zhang, Jia Shi, Jin-Tang Cheng, An Liu. [Preparation and quality standard of standard decoction of Phellodendri Chinensis Cortex pieces].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2018 Mar; 43(5):873-878. doi:
10.19540/j.cnki.cjcmm.20180105.012. [PMID: 29676081] - Jie Liang, Fuxue Chen, Fu Gu, Xin Liu, Feng Li, Dongshu Du. Expression and functional activity of bitter taste receptors in primary renal tubular epithelial cells and M-1 cells.
Molecular and cellular biochemistry.
2017 Apr; 428(1-2):193-202. doi:
10.1007/s11010-016-2929-1. [PMID: 28236092] - Lianrong Yang, Xin Meng, Xiaojin Yu, Haixue Kuang. Simultaneous determination of anemoside B4, phellodendrine, berberine, palmatine, obakunone, esculin, esculetin in rat plasma by UPLC-ESI-MS/MS and its application to a comparative pharmacokinetic study in normal and ulcerative colitis rats.
Journal of pharmaceutical and biomedical analysis.
2017 Feb; 134(?):43-52. doi:
10.1016/j.jpba.2016.11.021. [PMID: 27875787] - Yi Li, Xin-Guang Liu, Hui-Ying Wang, Xin Dong, Wen Gao, Xiao-Jun Xu, Ping Li, Hua Yang. Pharmacokinetic studies of phellodendrine in rat plasma and tissues after intravenous administration using ultra-high performance liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Sep; 1029-1030(?):95-101. doi:
10.1016/j.jchromb.2016.07.006. [PMID: 27428451] - Ling Li, Tao Huang, Cheng Tian, Yubo Xiao, Shuming Kou, Xia Zhou, Shanshan Liu, Xiaoli Ye, Xuegang Li. The defensive effect of phellodendrine against AAPH-induced oxidative stress through regulating the AKT/NF-κB pathway in zebrafish embryos.
Life sciences.
2016 Jul; 157(?):97-106. doi:
10.1016/j.lfs.2016.05.032. [PMID: 27234894] - Huawei Zhang, Peng Fu, Beilei Ke, Shuping Wang, Min Li, Lin Han, Chengcheng Peng, Weidong Zhang, Runhui Liu. Metabolomic analysis of biochemical changes in the plasma and urine of collagen-induced arthritis in rats after treatment with Huang-Lian-Jie-Du-Tang.
Journal of ethnopharmacology.
2014 May; 154(1):55-64. doi:
10.1016/j.jep.2014.03.007. [PMID: 24709313] - Huawu Zeng, Shengshan Dou, Jing Zhao, Siyang Fan, Xing Yuan, Shuanglai Zhu, Li Li, Weidong Zhang, Runhui Liu. The inhibitory activities of the components of Huang-Lian-Jie-Du-Tang (HLJDT) on eicosanoid generation via lipoxygenase pathway.
Journal of ethnopharmacology.
2011 May; 135(2):561-8. doi:
10.1016/j.jep.2011.03.055. [PMID: 21466840] - Yubo Li, Tiejun Zhang, Xiaolan Zhang, Haiyu Xu, Changxiao Liu. Chemical fingerprint analysis of Phellodendri Amurensis Cortex by ultra performance LC/Q-TOF-MS methods combined with chemometrics.
Journal of separation science.
2010 Nov; 33(21):3347-53. doi:
10.1002/jssc.201000426. [PMID: 21049522] - H Mori, M Fuchigami, N Inoue, H Nagai, A Koda, I Nishioka, K Meguro. Principle of the bark of Phellodendron amurense to suppress the cellular immune response: effect of phellodendrine on cellular and humoral immune responses.
Planta medica.
1995 Feb; 61(1):45-9. doi:
10.1055/s-2006-957997. [PMID: 7700991] - T Hattori, K Furuta, K Hayashi, T Nagamatsu, M Ito, Y Suzuki. Studies on the antinephritic effects of plant components (6): antinephritic effects and mechanisms of phellodendrine (OB-5) on crescentic-type anti-GBM nephritis in rats (2).
Japanese journal of pharmacology.
1992 Nov; 60(3):187-95. doi:
10.1254/jjp.60.187. [PMID: 1491511]
