Dacarbazine (BioDeep_00000000370)

 

Secondary id: BioDeep_00001867494

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


Dacarbazine, Pharmaceutical Secondary Standard; Certified Reference Material

化学式: C6H10N6O (182.0916)
中文名称: 达卡巴嗪
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 40.88%

分子结构信息

SMILES: CN(C)N/N=C\1/C(=NC=N1)C(=O)N
InChI: InChI=1S/C6H10N6O/c1-12(2)11-10-6-4(5(7)13)8-3-9-6/h3H,1-2H3,(H2,7,13)(H,8,9)

描述信息

Dacarbazine appears as white to ivory microcrystals or off-white crystalline solid. (NTP, 1992)
(E)-dacarbazine is a dacarbazine in which the N=N double bond adopts a trans-configuration.
An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma.
Dacarbazine is an Alkylating Drug. The mechanism of action of dacarbazine is as an Alkylating Activity.
Dacarbazine (also known as DTIC) is an intravenously administered alkylating agent used in the therapy of Hodgkin disease and malignant melanoma. Dacarbazine therapy has been associated with serum enzyme elevations during therapy and occasional cases of severe and distinctive acute hepatic failure, probably caused by acute sinusoidal obstruction syndrome.
Dacarbazine is a triazene derivative with antineoplastic activity. Dacarbazine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. (NCI04)
An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564)
Dacarbazine is only found in individuals that have used or taken this drug. It is an antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564)The mechanism of action is not known, but appears to exert cytotoxic effects via its action as an alkylating agent. Other theories include DNA synthesis inhibition by its action as a purine analog, and interaction with SH groups. Dacarbazine is not cell cycle-phase specific.
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01A - Alkylating agents
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D009676 - Noxae > D000477 - Alkylating Agents
D000970 - Antineoplastic Agents

同义名列表

124 个代谢物同义名

Dacarbazine, Pharmaceutical Secondary Standard; Certified Reference Material; Imidazole-4(or 5)-carboxamide, 5(or 4)-(3,3-dimethyl-1-triazeno)-; Dacarbazine, United States Pharmacopeia (USP) Reference Standard; 4-(or 5)-(3,3-Dimethyl-1-triazeno)imidazole-5(or 4)-carboxamide; 4-[(1E)-3,3-Dimethyltriaz-1-en-1-yl]-1H-imidazole-5-carboxamide; (5E)-5-(dimethylaminohydrazinylidene)imidazole-4-carboxamide; (5E)-5-(dimethylaminohydrazinylidene)-4-imidazolecarboxamide; Dacarbazine, European Pharmacopoeia (EP) Reference Standard; 5-[(1E)-dimethyltriaz-1-en-1-yl]-1H-imidazole-4-carboxamide; 1 H-IMIDAZOLE-4-CARBOXAMIDE, 5-(3,3-DIMETHYL-1-TRIAZENYL)-; Dacarbazine, British Pharmacopoeia (BP) Reference Standard; 5-(3,3-dimethyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide; 1H-imidazole-4-carboxamide, 5-(3,3-dimethyl-1-triazenyl)-; 4-(5)-(3,3-Dimethyl-1-triazeno)imidazole-5(4)-carboxamide; 4(5)-(3,3-Dimethyl-1-triazeno)imidazole-5(4)-carboxamide; 4-[(E)-dimethylaminodiazenyl]-1H-imidazole-5-carboxamide; 5-(3,3-Dimethyltriaz-1-enyl)-1H-imidazole-4-carboxamide; 5-(3,3-Dimethyl-1-triazenyl)-1H-imidazole-4-carboxamide; 5(or 4)-(dimethyltriazeno)imidazole-4(or 5)-carboxamide; 5-(3-3-dimethyl-1-triazenyl)-1H-imidazole-4-carboxamide; 5-(dimethyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide; (5Z)-5-(dimethylaminohydrazono)imidazole-4-carboxamide; (5E)-5-(dimethylaminohydrazono)imidazole-4-carboxamide; Imidazole-4-carboxamide, 5-(3,3-dimethyl-1-triazenyl)-; 5- (3,3-Dimethyl-1-triazenyl) imidazole-4-carboxamide; 4(5)-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide; IMIDAZOLE-4-CARBOXAMIDE, 5-(3,3-DIMETHYL-1-TRIAZENO1-; Imidazole-4(or 5)-carboxamide,3-dimethyl-1-triazeno)-; Imidazole-4-carboxamide, 5-(3,3-dimethyl-1-triazeno)-; Carboxamide, 5-(3,3-dimethyl-1-triazeno)imidazole-4-; 5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide; 4-[(E)-dimethylaminoazo]-1H-imidazole-5-carboxamide; 1H-Imidazole-4-carboxamide,3-dimethyl-1-triazenyl)-; 4-(3,3-Dimethyl-1-triazeno)imidazole-5-carboxamide; 5-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide; 5-(3,3-Dimethyltriazeno)imidazole-4-carboxamide; Imidazole-4-carboxamide,3-dimethyl-1-triazeno)-; Carboxamide,3-dimethyl-1-triazeno)imidazole-4-; 5-(Dimethyltriazeno)imidazole-4-carboxamide; 5-(Dimethyltriazeno)imidazole-4-carboximide; 4-(Dimethyltriazeno)imidazole-5-carboxamide; Dimethyl (triazeno) imidazolecarboxamide; Dimethyl-triazeno-imidazole-carboximide; Dimethyl Triazeno Imidazole Carboxamide; dimethyl-triazeno-imidazole carboxamide; Imidazole Carboxamide Dimethyltriazeno; (Dimethyltriazeno)imidazolecarboxamide; Dimethyl Triazeno Imidazol Carboxamide; Dimethyltriazenoimidazolecarboxamide; Dacarbazine [USAN:USP:INN:BAN:JAN]; Di-me-triazenoimidazolecarboxamide; Carboxamide, Dimethyl Imidazole; Imidazole Carboxamide, Dimethyl; Dimethyl Imidazole Carboxamide; DACARBAZINE [USP MONOGRAPH]; DACARBAZINUM [WHO-IP LATIN]; DACARBAZINE (USP MONOGRAPH); FDKXTQMXEQVLRF-ZHACJKMWSA-N; DACARBAZINE [EP MONOGRAPH]; DACARBAZINE (EP MONOGRAPH); DACARBAZINE [ORANGE BOOK]; Dacarbazine (JAN/USP/INN); Dacarbazino [INN-Spanish]; WLN: T5M CNJ DVZ ENUNN1&1; Dacarbazinum [INN-Latin]; Dacarbazine (DTIC-Dome); Imidazole carboxamide; DACARBAZINE [WHO-DD]; Dacarbazina Almirall; DACARBAZINE (USP-RS); DACARBAZINE [WHO-IP]; DACARBAZINE [USP-RS]; DACARBAZINE (MART.); DACARBAZINE [MART.]; DACARBAZINE [VANDF]; DACARBAZINE [USAN]; DACARBAZINE [IARC]; DACARBAZINE [HSDB]; dacarbazine - dtic; DACARBAZINE (IARC); DACARBAZINE [JAN]; DACARBAZINE [INN]; Dacarbazine-DTIC; DACARBAZINE [MI]; (E)-Dacarbazine; UNII-7GR28W0FJI; Tox21_111171_1; Biocarbazine R; Dtic-Dome (TN); Dacarbazinum; Tox21_111171; Biocarbazine; Tox21_201010; Dacarbazine; Dacarbasine; dacarbazina; Dacarbazino; Dicarbazine; Decarbazine; Dakarbazin; NCI-C04717; Dacarbazin; 7GR28W0FJI; NSC-45388; Fauldetic; AI3-52825; DTIC-Dome; Detimedac; DTIC Dome; dtic-aome; HSDB 3219; NSC 45388; Deticene; DTICDome; L01AX04; Asercit; Dacatic; ICDMT; DTIE; DTCI; DTIC; ICDT; DIC; Dacarbazine



数据库引用编号

25 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ANXA5, BCL2, BRAF, CASP3, TP53, VEGFA
Peripheral membrane protein 1 ANXA5
Endoplasmic reticulum membrane 4 BCL2, CD4, CYP1A2, NRAS
Nucleus 6 BCL2, BRAF, CASP3, PARP1, TP53, VEGFA
cytosol 8 ADRA2B, ANXA5, BCL2, BRAF, CASP3, NRAS, PARP1, TP53
nuclear body 1 PARP1
centrosome 1 TP53
nucleoplasm 3 CASP3, PARP1, TP53
Cell membrane 7 ADRA2B, BRAF, CD4, CD8A, NRAS, PDCD1, TNF
Lipid-anchor 1 NRAS
Cytoplasmic side 1 NRAS
Multi-pass membrane protein 1 ADRA2B
Golgi apparatus membrane 1 NRAS
cell surface 3 ADRA2B, TNF, VEGFA
glutamatergic synapse 2 BRAF, CASP3
Golgi apparatus 2 NRAS, VEGFA
Golgi membrane 1 NRAS
neuronal cell body 2 CASP3, TNF
postsynapse 1 BRAF
sarcolemma 1 ANXA5
Cytoplasm, cytosol 1 PARP1
Presynapse 1 BRAF
plasma membrane 9 ADRA2B, BRAF, CD4, CD8A, CSF2, IFNLR1, NRAS, PDCD1, TNF
Membrane 8 ANXA5, BCL2, IFNLR1, NRAS, PARP1, PDCD1, TP53, VEGFA
extracellular exosome 2 ANXA5, NRAS
endoplasmic reticulum 3 BCL2, TP53, VEGFA
extracellular space 7 CSF2, CSF3, CXCL8, IFNA1, IL2, TNF, VEGFA
lysosomal lumen 1 CSF3
adherens junction 1 VEGFA
mitochondrion 4 BCL2, BRAF, PARP1, TP53
protein-containing complex 3 BCL2, PARP1, TP53
intracellular membrane-bounded organelle 4 ADRA2B, BRAF, CSF2, CYP1A2
Microsome membrane 1 CYP1A2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 3 CD4, CD8A, IFNLR1
Secreted 6 CSF2, CSF3, CXCL8, IFNA1, IL2, VEGFA
extracellular region 8 ANXA5, CD8A, CSF2, CSF3, CXCL8, IL2, TNF, VEGFA
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
[Isoform 2]: Secreted 1 CD8A
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
transcription regulator complex 2 PARP1, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 5 ANXA5, CD4, CD8A, PDCD1, TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
nucleolus 2 PARP1, TP53
Early endosome 1 CD4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 2 CD4, TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 1 ANXA5
extracellular matrix 1 VEGFA
Nucleus, PML body 1 TP53
PML body 1 TP53
collagen-containing extracellular matrix 1 ANXA5
secretory granule 1 VEGFA
receptor complex 1 CD8A
Zymogen granule membrane 1 ANXA5
neuron projection 1 BRAF
chromatin 2 PARP1, TP53
phagocytic cup 1 TNF
Chromosome 1 PARP1
Nucleus, nucleolus 1 PARP1
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
site of double-strand break 2 PARP1, TP53
nuclear envelope 1 PARP1
tertiary granule membrane 1 NRAS
cell body 1 BRAF
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
plasma membrane raft 1 CD8A
endoplasmic reticulum lumen 1 CD4
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
platelet alpha granule lumen 1 VEGFA
vesicle membrane 1 ANXA5
clathrin-coated endocytic vesicle membrane 1 CD4
[Isoform 1]: Nucleus 1 TP53
protein-DNA complex 1 PARP1
death-inducing signaling complex 1 CASP3
[Isoform 1]: Cell membrane 1 CD8A
granulocyte macrophage colony-stimulating factor receptor complex 1 CSF2
site of DNA damage 1 PARP1
endocytic vesicle lumen 1 CSF3
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 2 CD4, CD8A
endothelial microparticle 1 ANXA5
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Herwig Strik, Thomas Efferth, Bernd Kaina. Artesunate in glioblastoma therapy: Case reports and review of clinical studies. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 123(?):155274. doi: 10.1016/j.phymed.2023.155274. [PMID: 38142662]
  • Nana Wang, Jiejun Wang, Pu Wang, Nan Ji, Shuhua Yue. Label-Free Raman Spectromicroscopy Unravels the Relationship between MGMT Methylation and Intracellular Lipid Accumulation in Glioblastoma. Analytical chemistry. 2023 08; 95(31):11567-11571. doi: 10.1021/acs.analchem.3c00967. [PMID: 37417930]
  • Junxia Pei, Zhou Su, Xin Zeng, Ya Zhong, Yamei Zhang, Yixi Yang, Qiuxia Lu, Jian Li, Yu Deng. Protocatechuic aldehyde acts synergistically with dacarbazine to augment DNA double-strand breaks and promote apoptosis in cutaneous melanoma cells. BMC complementary medicine and therapies. 2023 Apr; 23(1):111. doi: 10.1186/s12906-023-03933-w. [PMID: 37024907]
  • Sui Li, Xiaofang Xie, Fu Peng, Junrong Du, Cheng Peng. Regulation of temozolomide resistance via lncRNAs: Clinical and biological properties of lncRNAs in gliomas (Review). International journal of oncology. 2022 Sep; 61(3):. doi: 10.3892/ijo.2022.5391. [PMID: 35796022]
  • Yugo Horiuchi, Kenichi Hashimoto, Hideyuki Horikoshi, Azusa Sano, Yusuke Kawamura, Naoya Fujita, Motohiro Kimata, Yosuke Ono, Yasuhiro Obuchi, Arisa Makino, Mayuko Kaneko, Fumihiko Kimura, Kenji Itoh, Yuji Tanaka. Fulminant elderly adult-onset Still disease effectively treated with tocilizumab and methotrexate: A case report. Medicine. 2022 Jul; 101(28):e29354. doi: 10.1097/md.0000000000029354. [PMID: 35839054]
  • Valeria Internò, Roberta Rudà, Maria Chiara Sergi, Riccardo Soffietti, Camillo Porta. Newly diagnosed Glioblastoma Multiforme (GBM) during COVID-19 pandemic: changes in therapeutic approach to minimize in-hospital SARS-COV-2 contagion in pre-vaccine era. Acta bio-medica : Atenei Parmensis. 2022 Jul; 93(3):e2022067. doi: 10.23750/abm.v93i3.12452. [PMID: 35775774]
  • Federico Cucchiara, Giacomo Luci, Noemi Giannini, Filippo Sean Giorgi, Paola Orlandi, Marta Banchi, Antonello Di Paolo, Francesco Pasqualetti, Romano Danesi, Guido Bocci. Association of plasma levetiracetam concentration, MGMT methylation and sex with survival of chemoradiotherapy-treated glioblastoma patients. Pharmacological research. 2022 07; 181(?):106290. doi: 10.1016/j.phrs.2022.106290. [PMID: 35680010]
  • A D Makatsariya, E V Slukhanchuk, V O Bitsadze, J K H Khizroeva, M V Tretyakova, V I Tsibizova, I Elalamy, J-C Gris, E Grandone, N A Makatsariya, T Mashkova. Thrombotic microangiopathy, DIC-syndrome and COVID-19: link with pregnancy prothrombotic state. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 2022 Jul; 35(13):2536-2544. doi: 10.1080/14767058.2020.1786811. [PMID: 32627622]
  • Eduardo Gutiérrez-Abejón, Francisco Herrera-Gómez, M Aránzazu Pedrosa-Naudín, Eduardo Tamayo, F Javier Álvarez. Hospitalized COVID-19 Patients with Severe Acute Respiratory Syndrome: A Population-Based Registry Analysis to Assess Clinical Findings, Pharmacological Treatment and Survival. Medicina (Kaunas, Lithuania). 2022 Jun; 58(6):. doi: 10.3390/medicina58060829. [PMID: 35744092]
  • Noha A El-Bassiouny, Maged W Helmy, Mostafa Alaa Eldin Hassan, Gehan A Khedr. The Cardioprotective Effect of Vitamin D in Breast Cancer Patients Receiving Adjuvant Doxorubicin Based Chemotherapy. Clinical breast cancer. 2022 06; 22(4):359-366. doi: 10.1016/j.clbc.2022.01.008. [PMID: 35241369]
  • Huijuan Wang, Chunfang Zhang, Chao Zhang, Yishan Wang, Kan Zhai, Zhaohui Tong. MicroRNA-122-5p regulates coagulation and inflammation through MASP1 and HO-1 genes. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. 2022 06; 100(?):105268. doi: 10.1016/j.meegid.2022.105268. [PMID: 35293311]
  • Paul B Googe, Stamatios Theocharis, Alexandros Pergaris, Haocheng Li, Yibing Yan, Edward F McKenna, Stergios J Moschos. Theragnostic significance of tumor-infiltrating lymphocytes and Ki67 in BRAFV600-mutant metastatic melanoma (BRIM-3 trial). Current problems in cancer. 2022 06; 46(3):100862. doi: 10.1016/j.currproblcancer.2022.100862. [PMID: 35398635]
  • Azra Kugić, Sanja Dabelić, Cvijeta Jakobušić Brala, Nina Dabelić, Monika Barbarić. Extra Virgin Olive Oil Secoiridoids Modulate the Metabolic Activity of Dacarbazine Pre-Treated and Treatment-Naive Melanoma Cells. Molecules (Basel, Switzerland). 2022 May; 27(10):. doi: 10.3390/molecules27103310. [PMID: 35630786]
  • Alessandro Malagoli, Luca Rossi, Alessia Zanni, Federico Muto, Alberto Tosetti, Stefano Tondi. Sustained right ventricular dysfunction in severe COVID-19: The role of disseminated intravascular coagulation. Echocardiography (Mount Kisco, N.Y.). 2022 04; 39(4):584-591. doi: 10.1111/echo.15332. [PMID: 35277886]
  • Elsa P Bianchini, Mahita Razanakolona, Julie Helms, Fouzia Zouiti, Amélie Couteau-Chardon, Viviana Marin-Esteban, Luc de Chaisemartin, Allan De-Carvalho, Roselyne Bironien, Sylvie Chollet-Martin, Cécile V Denis, Jean-Luc Diehl, Marc Vasse, Ferhat Meziani, Delphine Borgel. The Proteolytic Inactivation of Protein Z-Dependent Protease Inhibitor by Neutrophil Elastase Might Promote the Procoagulant Activity of Neutrophil Extracellular Traps in Sepsis. Thrombosis and haemostasis. 2022 04; 122(4):506-516. doi: 10.1055/a-1530-3980. [PMID: 34134169]
  • Larissa J Sanches, Poliana C Marinello, Walison A da Silva Brito, Natália M D Lopes, Rodrigo C Luiz, Rubens Cecchini, Alessandra L Cecchini. Metformin pretreatment reduces effect to dacarbazine and suppresses melanoma cell resistance. Cell biology international. 2022 Jan; 46(1):73-82. doi: 10.1002/cbin.11700. [PMID: 34506671]
  • Keisuke Mori, Yasuyuki Tsujita, Tetsunobu Yamane, Yutaka Eguchi. Decreasing Plasma Fibrinogen Levels in the Intensive Care Unit Are Associated with High Mortality Rates In Patients With Sepsis-Induced Coagulopathy. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. 2022 Jan; 28(?):10760296221101386. doi: 10.1177/10760296221101386. [PMID: 35549920]
  • Hiroyuki Fujii, Taisuke Tsuji, Mio Sugitani, Yosuke Matsumoto, Tatsuya Yuba, Shunya Tanaka, Yoshifumi Suga, Aosa Matsuyama, Shiho Goda, Ayaka Omura, Shinsuke Shiotsu, Chieko Takumi, Seiko Ono, Noriya Hiraoka. Prolonged persistence of SARS-CoV-2 infection during A+AVD therapy for classical Hodgkin's lymphoma: A case report. Current problems in cancer. 2021 12; 45(6):100739. doi: 10.1016/j.currproblcancer.2021.100739. [PMID: 33810911]
  • Patrick M Honore, Sebastien Redant, Thierry Preseau, Keitiane Kaefer, Leonel Barreto Gutierrez, Rachid Attou, Andrea Gallerani, David De Bels. In Septic ICU Patients, Presepsin is Predictor of AKI, ARDS, and DIC: Beware of Some Potential Confounding Factors!. Shock (Augusta, Ga.). 2021 12; 56(6):1092. doi: 10.1097/shk.0000000000001802. [PMID: 33927138]
  • Yuichiro Shimoyama, Osamu Umegaki, Noriko Kadono, Toshiaki Minami. Response to A Letter to the Editor: In Septic ICU Patients, Presepsin is A Predictor of AKI, ARDS, and DIC-Renal Replacement Therapy Initiation only has A Minor Impact on The Results of The Present Study. Shock (Augusta, Ga.). 2021 12; 56(6):1092-1093. doi: 10.1097/shk.0000000000001801. [PMID: 33927139]
  • Hongxu Liu, William Kwame Amakye, Jiaoyan Ren. Codonopsis pilosula polysaccharide in synergy with dacarbazine inhibits mouse melanoma by repolarizing M2-like tumor-associated macrophages into M1-like tumor-associated macrophages. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Oct; 142(?):112016. doi: 10.1016/j.biopha.2021.112016. [PMID: 34385100]
  • Tejashree Waghule, Ranendra Narayan Saha, Gautam Singhvi. UV spectroscopic method for estimation of temozolomide: Application in stability studies in simulated plasma pH, degradation rate kinetics, formulation design, and selection of dissolution media. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2021 Sep; 258(?):119848. doi: 10.1016/j.saa.2021.119848. [PMID: 33933945]
  • Mae Xintong Huo, Alzira Rocheteau M Avelino, Gurpreet Singh. Severe cutaneous presentation of hydralazine-induced ANCA vasculitis without renal or pulmonary involvement, complicated by DIC. BMJ case reports. 2021 May; 14(5):. doi: 10.1136/bcr-2020-238609. [PMID: 33975832]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Ying Liu, Li-Ying Sun, Zhi-Jun Zhu, Lin Wei, Wei Qu, Lin Wang, Lei-Lei Yuan, Zhi-Gui Zeng. Post-transplant lymphoproliferative disorder after paediatric liver transplantation. International journal of clinical practice. 2021 Apr; 75(4):e13843. doi: 10.1111/ijcp.13843. [PMID: 33222369]
  • Buket Kara, Kubilay K Kart, Yavuz Koksal. A Prolonged Activated Partial Thromboplastin Time in a Child With Hodgkin Lymphoma. Journal of pediatric hematology/oncology. 2021 04; 43(3):e401-e403. doi: 10.1097/mph.0000000000001732. [PMID: 32000198]
  • Akinleye Stephen Akinrinde, Halimot Olawalarami Hameed. Glycine and L-Arginine supplementation ameliorates gastro-duodenal toxicity in a rat model of NSAID (Diclofenac)-gastroenteropathy via inhibition of oxidative stress. Journal of basic and clinical physiology and pharmacology. 2021 Feb; 33(3):285-295. doi: 10.1515/jbcpp-2020-0307. [PMID: 33559459]
  • Yuhua Yue, Bingjun Zhou, Jiayuan Ai, Shun Feng. [Determination of dacarbazine in the urine of mice with melanoma by high performance liquid chromatography]. Se pu = Chinese journal of chromatography. 2020 Nov; 38(11):1302-1307. doi: 10.3724/sp.j.1123.2020.01003. [PMID: 34213101]
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