Tamarixetin (BioDeep_00000003683)

   

natural product PANOMIX_OTCML-2023


代谢物信息卡片


4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-

化学式: C16H12O7 (316.0583)
中文名称: 柽柳黄素, 4-O-甲基-d3槲皮素
谱图信息: 最多检出来源 Viridiplantae(plant) 26.45%

分子结构信息

SMILES: c1(cc(c2c(c1)oc(c(c2=O)O)c1ccc(c(c1)O)OC)O)O
InChI: InChI=1S/C16H12O7/c1-22-11-3-2-7(4-9(11)18)16-15(21)14(20)13-10(19)5-8(17)6-12(13)23-16/h2-6,17-19,21H,1H3

描述信息

Tamarixetin is a monomethoxyflavone that is quercetin methylated at position O-4. Isolated from Cyperus teneriffae. It has a role as a metabolite and an antioxidant. It is a 7-hydroxyflavonol, a monomethoxyflavone and a tetrahydroxyflavone. It is functionally related to a quercetin.
Tamarixetin is a natural product found in Ageratina altissima, Chromolaena odorata, and other organisms with data available.
See also: Trifolium pratense flower (part of).
A monomethoxyflavone that is quercetin methylated at position O-4. Isolated from Cyperus teneriffae.
Tamarixetin (4'-O-Methyl Quercetin) is a natural flavonoid derivative of quercetin, with anti-oxidative and anti-inflammatory effects. Tamarixetin protects against cardiac hypertrophy[1][2].
Tamarixetin (4'-O-Methyl Quercetin) is a natural flavonoid derivative of quercetin, with anti-oxidative and anti-inflammatory effects. Tamarixetin protects against cardiac hypertrophy[1][2].

同义名列表

36 个代谢物同义名

4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-; 3,5,7-Trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one; 3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one; 3,5,7-trihydroxy-2-(3-hydroxy-4-methoxy-phenyl)chromen-4-one; 3,5,7-Trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone; 3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-one; 3-O-alpha-L-rhamnopyranosyl-1-2-beta-D-glucopyranoside; FLAVONE, 4-METHOXY-3,3,5,7-TETRAHYDROXY-; Flavone, 3,3,5,7-tetrahydroxy-4-methoxy-; 3-O-rhamnopyranosyl-1-2-glucopyranoside; 4-Methoxy-3,3,5,7-tetrahydroxy-flavone; 4-Methoxy-3,3,5,7-tetrahydroxyflavone; 3,3,5,7-tetrahydroxy-4-methoxyflavone; 3,3,5,7-Tetrahydroxy-4-methoxyflavone; 4-methoxy-3,5,7,3-tetrahydroflavone; FPLMIPQZHHQWHN-UHFFFAOYSA-N; Quercetin, 4-methyl ether; Quercetin 4-methyl ether; Quercetin-4-methylether; 4-O-Methyl Quercetin; 4-O-Methylquercetin; 4-Methoxyquercetin; 4-Methylquercetin; UNII-73WRA8Z8M8; Tamarixetin; 73WRA8Z8M8; 3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-chromenone; 3,5,7-trihydroxy-2-(3-hydroxy-4-methoxy-phenyl)chromone; ST5331691; 603-61-2; C10188; 3,5,7-Trihydroxy-2- (3-hydroxy-4-methoxyphenyl) -4H-1-benzopyran-4-one; Quercetin 3-methyl ether; Isorhamnetin; 4'-O-Methyl Quercetin; Tamarixetin



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

109 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 ABCB1, AKT1, BCL2, CASP3, CAT, CEBPB, CYP3A4, HSP90AA1, KAT2B, KEAP1, MAPK14, NCOA3, PIK3CA
Peripheral membrane protein 1 CYP1B1
Endoplasmic reticulum membrane 4 BCL2, CYP1A2, CYP1B1, CYP3A4
Nucleus 10 AKT1, BCL2, CASP3, CEBPA, CEBPB, HSP90AA1, KAT2B, KEAP1, MAPK14, NCOA3
cytosol 10 AKT1, BCL2, CASP3, CAT, HSP90AA1, KAT2B, KEAP1, MAPK14, NCOA3, PIK3CA
centrosome 1 KAT2B
nucleoplasm 9 AKT1, CASP3, CEBPA, CEBPB, HSP90AA1, KAT2B, KEAP1, MAPK14, NCOA3
RNA polymerase II transcription regulator complex 2 CEBPA, CEBPB
Cell membrane 3 ABCB1, AKT1, HSP90AA1
lamellipodium 2 AKT1, PIK3CA
Multi-pass membrane protein 1 ABCB1
cell cortex 1 AKT1
cell surface 2 ABCB1, HSP90AA1
glutamatergic synapse 3 AKT1, CASP3, MAPK14
Golgi membrane 1 INS
neuronal cell body 2 CASP3, HSP90AA1
postsynapse 1 AKT1
plasma membrane 4 ABCB1, AKT1, HSP90AA1, PIK3CA
Membrane 7 ABCB1, AKT1, BCL2, CAT, CYP1B1, CYP3A4, HSP90AA1
apical plasma membrane 2 ABCB1, HSP90AA1
basolateral plasma membrane 1 HSP90AA1
extracellular exosome 4 ABCB1, CAT, HSP90AA1, NCOA3
endoplasmic reticulum 2 BCL2, KEAP1
extracellular space 3 IL10, IL6, INS
lysosomal lumen 1 HSP90AA1
perinuclear region of cytoplasm 2 HSP90AA1, PIK3CA
intercalated disc 1 PIK3CA
mitochondrion 6 BCL2, CAT, CLPP, CYP1B1, HSP90AA1, MAPK14
protein-containing complex 6 AKT1, BCL2, CAT, HSP90AA1, KAT2B, NCOA3
intracellular membrane-bounded organelle 5 CAT, CEBPA, CYP1A2, CYP1B1, CYP3A4
Microsome membrane 3 CYP1A2, CYP1B1, CYP3A4
postsynaptic density 1 CASP3
Secreted 3 IL10, IL6, INS
extracellular region 6 CAT, HSP90AA1, IL10, IL6, INS, MAPK14
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
Mitochondrion matrix 1 CLPP
mitochondrial matrix 2 CAT, CLPP
transcription regulator complex 1 CEBPA
centriolar satellite 1 KEAP1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 KAT2B
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
microtubule cytoskeleton 1 AKT1
nucleolus 1 CEBPA
midbody 1 KEAP1
cell-cell junction 1 AKT1
vesicle 1 AKT1
Apical cell membrane 1 ABCB1
pore complex 1 BCL2
focal adhesion 1 CAT
spindle 1 AKT1
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 HSP90AA1
nuclear speck 1 MAPK14
actomyosin 1 KAT2B
ciliary basal body 1 AKT1
chromatin 3 CEBPA, CEBPB, NCOA3
axonal growth cone 1 HSP90AA1
mitotic spindle 1 KAT2B
brush border membrane 1 HSP90AA1
spindle pole 1 MAPK14
condensed chromosome, centromeric region 1 CEBPB
actin filament 1 KEAP1
Cul3-RING ubiquitin ligase complex 1 KEAP1
endosome lumen 1 INS
I band 1 KAT2B
Melanosome 1 HSP90AA1
dendritic growth cone 1 HSP90AA1
myelin sheath 2 BCL2, HSP90AA1
sperm mitochondrial sheath 1 HSP90AA1
sperm plasma membrane 1 HSP90AA1
ficolin-1-rich granule lumen 3 CAT, HSP90AA1, MAPK14
secretory granule lumen 4 CAT, HSP90AA1, INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 IL6, INS
nuclear matrix 1 CEBPB
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
kinetochore 1 KAT2B
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
A band 1 KAT2B
SAGA complex 1 KAT2B
external side of apical plasma membrane 1 ABCB1
death-inducing signaling complex 1 CASP3
ATAC complex 1 KAT2B
endopeptidase Clp complex 1 CLPP
endocytic vesicle lumen 1 HSP90AA1
catalase complex 1 CAT
inclusion body 1 KEAP1
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
C/EBP complex 2 CEBPA, CEBPB
CHOP-C/EBP complex 2 CEBPA, CEBPB
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[Isoform 4]: Nucleus, nucleolus 1 CEBPA


文献列表

  • Muhammad Umar Ijaz, Mehrab Khalil, Ali Hamza, Aisha Khatoon. Attenuative effects of tamarixetin against polystyrene microplastics-induced hepatotoxicity in rats by regulation of Nrf-2/Keap-1 pathway. Cell biochemistry and function. 2023 Dec; 41(8):1451-1461. doi: 10.1002/cbf.3885. [PMID: 38009818]
  • Hyo-Jin Kim, Jangho Lee, Min-Yu Chung, Soo Hyun Park, Jae Ho Park, Hyo-Kyoung Choi, Jin-Taek Hwang. Tamarixetin Abrogates Adipogenesis Through Inhibiting p300/CBP-Associated Factor Acetyltransferase Activity in 3T3-L1 Preadipocyte Cells. Journal of medicinal food. 2022 Mar; 25(3):272-280. doi: 10.1089/jmf.2021.k.0126. [PMID: 35320012]
  • Maiko Sakai, Kohta Ohnishi, Masashi Masuda, Hirokazu Ohminami, Hisami Yamanaka-Okumura, Taichi Hara, Yutaka Taketani. Isorhamnetin, a 3'-methoxylated flavonol, enhances the lysosomal proteolysis in J774.1 murine macrophages in a TFEB-independent manner. Bioscience, biotechnology, and biochemistry. 2020 Jun; 84(6):1221-1231. doi: 10.1080/09168451.2020.1727309. [PMID: 32046625]
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  • Itziar Eseberri, Jonatan Miranda, Arrate Lasa, Andrea Mosqueda-Solís, Susana González-Manzano, Celestino Santos-Buelga, Maria P Portillo. Effects of Quercetin Metabolites on Triglyceride Metabolism of 3T3-L1 Preadipocytes and Mature Adipocytes. International journal of molecular sciences. 2019 Jan; 20(2):. doi: 10.3390/ijms20020264. [PMID: 30641871]
  • Kengo Hayamizu, Sachio Morimoto, Miki Nonaka, Sumio Hoka, Toshiyuki Sasaguri. Cardiotonic actions of quercetin and its metabolite tamarixetin through a digitalis-like enhancement of Ca2+ transients. Archives of biochemistry and biophysics. 2018 01; 637(?):40-47. doi: 10.1016/j.abb.2017.11.009. [PMID: 29169900]
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  • Constanze Burak, Verena Brüll, Peter Langguth, Benno F Zimmermann, Birgit Stoffel-Wagner, Udo Sausen, Peter Stehle, Siegfried Wolffram, Sarah Egert. Higher plasma quercetin levels following oral administration of an onion skin extract compared with pure quercetin dihydrate in humans. European journal of nutrition. 2017 Feb; 56(1):343-353. doi: 10.1007/s00394-015-1084-x. [PMID: 26482244]
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