Cheilanthifoline (BioDeep_00000003656)

 

Secondary id: BioDeep_00001869269

natural product PANOMIX_OTCML-2023


代谢物信息卡片


(13S)-16-methoxy-5,7-dioxa-1-azapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),9,14,16,18-hexaen-17-ol

化学式: C19H19NO4 (325.1314)
中文名称: 碎叶紫堇碱
谱图信息: 最多检出来源 Viridiplantae(plant) 16.91%

分子结构信息

SMILES: COC1=C(C=C2C3CC4=C(CN3CCC2=C1)C5=C(C=C4)OCO5)O
InChI: InChI=1S/C19H19NO4/c1-22-18-7-12-4-5-20-9-14-11(2-3-17-19(14)24-10-23-17)6-15(20)13(12)8-16(18)21/h2-3,7-8,15,21H,4-6,9-10H2,1H3/t15-/m0/s1

描述信息

Cheilanthifoline is a natural product found in Fumaria densiflora, Fumaria judaica, and other organisms with data available.

同义名列表

5 个代谢物同义名

Cheilanthifoline; (13S)-16-methoxy-5,7-dioxa-1-azapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),9,14,16,18-hexaen-17-ol; (6aS)-6,6a,11,14-Tetrahydro-8-methoxy-12H-benzo[a]-1,3- benzodioxolo[4,5-g]quinolizim-9-ol; (S)-Cheilanthifoline; (S)-Cheilanthifoline



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(1)

代谢反应

28 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(2)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(26)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

48 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 BCL2, CDK1, MMP3, PIK3CA
Peripheral membrane protein 2 ACHE, CYP1B1
Endoplasmic reticulum membrane 3 BCL2, CDK1, CYP1B1
Nucleus 4 ACHE, BCL2, CDK1, MMP3
cytosol 5 BCL2, CDK1, MMP3, PIK3CA, TNFRSF11A
centrosome 1 CDK1
nucleoplasm 1 CDK1
Cell membrane 2 ACHE, TNF
lamellipodium 1 PIK3CA
Synapse 1 ACHE
cell surface 2 ACHE, TNF
Golgi apparatus 1 ACHE
neuromuscular junction 1 ACHE
neuronal cell body 1 TNF
plasma membrane 4 ACHE, PIK3CA, TNF, TNFRSF11A
Membrane 4 ACHE, BCL2, CDK1, CYP1B1
extracellular exosome 1 CDK1
endoplasmic reticulum 1 BCL2
extracellular space 7 ACHE, IL10, IL17A, IL4, MMP1, MMP3, TNF
perinuclear region of cytoplasm 2 ACHE, PIK3CA
intercalated disc 1 PIK3CA
mitochondrion 4 BCL2, CDK1, CYP1B1, MMP3
protein-containing complex 1 BCL2
intracellular membrane-bounded organelle 1 CYP1B1
Microsome membrane 1 CYP1B1
Single-pass type I membrane protein 1 TNFRSF11A
Secreted 5 ACHE, IL10, IL17A, IL4, MMP3
extracellular region 7 ACHE, IL10, IL17A, IL4, MMP1, MMP3, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
mitochondrial matrix 1 CDK1
Extracellular side 1 ACHE
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 CDK1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 3 IL17A, TNF, TNFRSF11A
Secreted, extracellular space, extracellular matrix 1 MMP1
midbody 1 CDK1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 2 TNF, TNFRSF11A
pore complex 1 BCL2
extracellular matrix 2 MMP1, MMP3
basement membrane 1 ACHE
phagocytic cup 1 TNF
mitotic spindle 1 CDK1
chromosome, telomeric region 1 CDK1
Lipid-anchor, GPI-anchor 1 ACHE
side of membrane 1 ACHE
myelin sheath 1 BCL2
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
synaptic cleft 1 ACHE
spindle microtubule 1 CDK1
[Isoform 1]: Cell membrane 1 TNFRSF11A
cyclin-dependent protein kinase holoenzyme complex 1 CDK1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
cyclin A1-CDK1 complex 1 CDK1
cyclin A2-CDK1 complex 1 CDK1
cyclin B1-CDK1 complex 1 CDK1
BAD-BCL-2 complex 1 BCL2
[Isoform H]: Cell membrane 1 ACHE
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
[Isoform RANK-e5a]: Cell membrane 1 TNFRSF11A


文献列表

  • Chang Gao, Yue Du, Xin Wang, Huikun Cao, Bin Lin, Youping Liu, Xin Di. Hexahydrobenzophenanthridine alkaloids from Corydalis bungeana Turcz. and their anti-inflammatory activity. Bioorganic & medicinal chemistry letters. 2018 07; 28(13):2265-2269. doi: 10.1016/j.bmcl.2018.05.039. [PMID: 29853329]
  • Phurpa Wangchuk, Paul A Keller, Stephen G Pyne, Anthony C Willis, Sumalee Kamchonwongpaisan. Antimalarial alkaloids from a Bhutanese traditional medicinal plant Corydalis dubia. Journal of ethnopharmacology. 2012 Aug; 143(1):310-3. doi: 10.1016/j.jep.2012.06.037. [PMID: 22796506]
  • Ki Hyun Kim, Il Kyun Lee, Cheng Jie Piao, Sang Un Choi, Jei Hyun Lee, Yeong Shik Kim, Kang Ro Lee. Benzylisoquinoline alkaloids from the tubers of Corydalis ternata and their cytotoxicity. Bioorganic & medicinal chemistry letters. 2010 Aug; 20(15):4487-90. doi: 10.1016/j.bmcl.2010.06.035. [PMID: 20594848]