Haplopine (BioDeep_00000003653)

   

natural product PANOMIX_OTCML-2023


代谢物信息卡片


4,8-Dimethoxyfuro[2,3-b]quinolin-7-ol; 7-Hydroxy-8-methoxydictamnine

化学式: C13H11NO4 (245.0688)
中文名称:
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 85.58%

分子结构信息

SMILES: COC1=C2C=COC2=NC3=C1C=CC(=C3OC)O
InChI: InChI=1S/C13H11NO4/c1-16-11-7-3-4-9(15)12(17-2)10(7)14-13-8(11)5-6-18-13/h3-6,15H,1-2H3

描述信息

Haplopine is an oxacycle, an organonitrogen heterocyclic compound and an organic heterotricyclic compound.
Haplopine is a natural product found in Haplophyllum bucharicum, Haplophyllum cappadocicum, and other organisms with data available.

同义名列表

15 个代谢物同义名

4,8-Dimethoxyfuro[2,3-b]quinolin-7-ol; 7-Hydroxy-8-methoxydictamnine; 4,8-dimethoxy-furo[2,3-b]quinolin-7-ol, AldrichCPR; Furo[2,3-b]quinoline, 4,8-dimethoxy-7-hydroxy-; 4,8-dimethoxy-7-hydroxyfuro(2,3-b)quinoline; 4,8-dimethoxyfuro[2,3-b]quinolin-7(9h)-one; 4,8-dimethoxy-9H-furo[2,3-b]quinolin-7-one; Furo(2,3-b)quinolin-7-ol, 4,8-dimethoxy-; 4,8-dimethoxyfuro[2,3-b]quinolin-7-ol; Heliparvifoline; TimTec1_005697; Oprea1_182538; Oprea1_418227; Haplopine; AC1L4WKL; Haplopine



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

76 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 IL13, MAPK14, POMC, PTGS2, TYR
Peripheral membrane protein 1 PTGS2
Endoplasmic reticulum membrane 6 HMOX1, PTGS2, UGT1A3, UGT1A7, UGT1A9, UGT2B4
Nucleus 2 HMOX1, MAPK14
cytosol 3 HMOX1, MAPK14, PDE5A
nucleoplasm 2 HMOX1, MAPK14
Cell membrane 1 TNF
Cytoplasmic side 1 HMOX1
cell surface 1 TNF
glutamatergic synapse 1 MAPK14
neuronal cell body 1 TNF
Lysosome 1 TYR
plasma membrane 3 CSF2, IGHE, TNF
Membrane 4 HMOX1, UGT1A3, UGT1A7, UGT1A9
caveola 1 PTGS2
endoplasmic reticulum 5 HMOX1, PTGS2, UGT1A3, UGT1A7, UGT1A9
extracellular space 9 CSF2, CSF3, HMOX1, IGHE, IL13, IL4, POMC, TNF, TSLP
lysosomal lumen 1 CSF3
perinuclear region of cytoplasm 2 HMOX1, TYR
mitochondrion 1 MAPK14
protein-containing complex 1 PTGS2
intracellular membrane-bounded organelle 2 CSF2, TYR
Microsome membrane 1 PTGS2
Single-pass type I membrane protein 2 IGHE, TYR
Secreted 6 CSF2, CSF3, IL13, IL4, POMC, TSLP
extracellular region 10 CSF2, CSF3, DNAH9, IGHE, IL13, IL4, MAPK14, POMC, TNF, TSLP
Single-pass membrane protein 4 UGT1A3, UGT1A7, UGT1A9, UGT2B4
mitochondrial outer membrane 1 HMOX1
motile cilium 1 DNAH9
external side of plasma membrane 2 IL13, TNF
Melanosome membrane 1 TYR
Golgi-associated vesicle 1 TYR
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 1 TNF
microtubule 1 DNAH9
secretory granule 1 POMC
axoneme 1 DNAH9
nuclear speck 1 MAPK14
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
IgE immunoglobulin complex 1 IGHE
phagocytic cup 1 TNF
spindle pole 1 MAPK14
Cytoplasm, cytoskeleton, cilium axoneme 1 DNAH9
[Isoform 2]: Cell membrane 1 IGHE
Melanosome 1 TYR
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 2 MAPK14, POMC
endoplasmic reticulum lumen 1 PTGS2
9+2 motile cilium 1 DNAH9
dynein complex 1 DNAH9
Single-pass type IV membrane protein 1 HMOX1
granulocyte macrophage colony-stimulating factor receptor complex 1 CSF2
[Isoform 3]: Cell membrane 1 IGHE
endocytic vesicle lumen 1 CSF3
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
outer dynein arm 1 DNAH9
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
distal portion of axoneme 1 DNAH9


文献列表

  • Ming-Jen Cheng, Kuo-Hsiung Lee, Ian-Lih Tsai, Ih-Sheng Chen. Two new sesquiterpenoids and anti-HIV principles from the root bark of Zanthoxylum ailanthoides. Bioorganic & medicinal chemistry. 2005 Nov; 13(21):5915-20. doi: 10.1016/j.bmc.2005.07.050. [PMID: 16140017]
  • L Puricelli, G Innocenti, G Delle Monache, R Caniato, R Filippini, E M Cappelletti. In vivo and in vitro production of alkaloids by Haplophyllum patavinum. Natural product letters. 2002 Apr; 16(2):95-100. doi: 10.1080/10575630290019985. [PMID: 11990434]
  • G T Tan, J M Pezzuto, A D Kinghorn, S H Hughes. Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. Journal of natural products. 1991 Jan; 54(1):143-54. doi: 10.1021/np50073a012. [PMID: 1710653]