Anisomycin (BioDeep_00000003605)

   

natural product Chemicals and Drugs


代谢物信息卡片


Flagecidin;Wuningmeisu C

化学式: C14H19NO4 (265.1314)
中文名称: 茴香霉素
谱图信息: 最多检出来源 Viridiplantae(plant) 18.79%

分子结构信息

SMILES: CC(=O)OC1C(CNC1CC2=CC=C(C=C2)OC)O
InChI: InChI=1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3

描述信息

An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
D004791 - Enzyme Inhibitors > D011500 - Protein Synthesis Inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
C254 - Anti-Infective Agent > C258 - Antibiotic
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.392
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.387
Anisomycin is a potent protein synthesis inhibitor which interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system[1]. Anisomycin is a JNK activator, which increases phospho-JNK[2][3]. Anisomycin is a bacterial antibiotic[4].

同义名列表

6 个代谢物同义名

(-)-anisomycin; Anisomycin; Flagecidin;Wuningmeisu C; Flagecidin; Wuningmeisu C; Anisomycin



数据库引用编号

42 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 AKT1, BCL2, BDNF, CA1, CASP3, CASP8, EGFR, MAPK14, MAPK8, MAPK9, PIK3CA, PRKX, STAT3, TP53
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 2 BCL2, EGFR
Nucleus 12 AKT1, BCL2, CASP3, CASP8, EGFR, JUN, MAPK14, MAPK8, MAPK9, PRKX, STAT3, TP53
cytosol 11 AKT1, BCL2, CA1, CASP3, CASP8, MAPK14, MAPK8, MAPK9, PIK3CA, STAT3, TP53
dendrite 1 BDNF
centrosome 1 TP53
nucleoplasm 10 AKT1, CASP3, CASP8, JUN, MAPK14, MAPK8, MAPK9, PRKX, STAT3, TP53
RNA polymerase II transcription regulator complex 2 JUN, STAT3
Cell membrane 3 AKT1, EGFR, TNF
lamellipodium 3 AKT1, CASP8, PIK3CA
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Synapse 1 MAPK8
cell cortex 1 AKT1
cell junction 1 EGFR
cell surface 2 EGFR, TNF
glutamatergic synapse 4 AKT1, CASP3, EGFR, MAPK14
Golgi membrane 2 EGFR, INS
lysosomal membrane 1 EGF
neuronal cell body 2 CASP3, TNF
postsynapse 1 AKT1
synaptic vesicle 1 BDNF
endosome 1 EGFR
plasma membrane 7 AKT1, EGF, EGFR, MAPK9, PIK3CA, STAT3, TNF
Membrane 6 AKT1, BCL2, BDNF, EGF, EGFR, TP53
apical plasma membrane 1 EGFR
axon 3 BDNF, CCK, MAPK8
basolateral plasma membrane 1 EGFR
extracellular exosome 2 CA1, EGF
endoplasmic reticulum 2 BCL2, TP53
extracellular space 7 BDNF, CCK, EGF, EGFR, IL6, INS, TNF
perinuclear region of cytoplasm 3 BDNF, EGFR, PIK3CA
Schaffer collateral - CA1 synapse 1 MAPK9
intercalated disc 1 PIK3CA
mitochondrion 5 BCL2, CASP8, MAPK14, MAPK9, TP53
protein-containing complex 5 AKT1, BCL2, CASP8, EGFR, TP53
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 EGFR
Secreted 4 BDNF, CCK, IL6, INS
extracellular region 7 BDNF, CCK, EGF, IL6, INS, MAPK14, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, CASP8
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
transcription regulator complex 3 JUN, STAT3, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, EGFR
external side of plasma membrane 1 TNF
microtubule cytoskeleton 1 AKT1
nucleolus 1 TP53
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Cell projection, lamellipodium 1 CASP8
Membrane raft 2 EGFR, TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 1 EGFR
spindle 1 AKT1
intracellular vesicle 1 EGFR
Nucleus, PML body 1 TP53
PML body 1 TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
nuclear speck 2 MAPK14, MAPK9
receptor complex 1 EGFR
ciliary basal body 1 AKT1
chromatin 3 JUN, STAT3, TP53
phagocytic cup 1 TNF
cytoskeleton 1 CASP8
spindle pole 1 MAPK14
nuclear chromosome 1 JUN
site of double-strand break 1 TP53
endosome lumen 1 INS
euchromatin 1 JUN
cell body 1 CASP8
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 2 INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 BDNF, IL6, INS
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
platelet alpha granule lumen 1 EGF
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
clathrin-coated endocytic vesicle membrane 2 EGF, EGFR
[Isoform 1]: Nucleus 1 TP53
basal dendrite 1 MAPK8
CD95 death-inducing signaling complex 1 CASP8
death-inducing signaling complex 2 CASP3, CASP8
ripoptosome 1 CASP8
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
transcription factor AP-1 complex 1 JUN
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Jing Shu, Kexin Cao, Chuanjiang Fei, Hui Dai, Yuhang Li, Yi Cao, Tao Zhou, Miao Yu, Zihao Xia, Mengnan An, Yuanhua Wu. Antiviral Mechanisms of Anisomycin Produced by Streptomyces albulus SN40 on Potato Virus Y. Journal of agricultural and food chemistry. 2024 Feb; 72(7):3506-3519. doi: 10.1021/acs.jafc.3c07732. [PMID: 38346922]
  • Lele Ling, Yichao Wen, Ying Xiong, Xin Liu, Juan Chen, Te Liu, Bimeng Zhang. Anisomycin inhibits the activity of human ovarian cancer stem cells via regulating antisense RNA NCPB2-AS2/MEK/ERK/STAT3 signaling. The journal of gene medicine. 2023 Jul; ?(?):e3571. doi: 10.1002/jgm.3571. [PMID: 37483091]
  • Can-Can Zhou, Yu-Qiong He, Yu-Shuang Qiu, Chen-Xu Ni, Fu-Ming Shen, Dong-Jie Li. Zinc supplementation ameliorates sorafenib-induced cognitive impairment through ROS/JNK signaling pathway. Biological trace element research. 2023 Jan; 201(1):324-337. doi: 10.1007/s12011-022-03142-5. [PMID: 35129807]
  • Rafat Zrieq, Mejdi Snoussi, Fahad D Algahtan, Munazzah Tasleem, Mohd Saeed, Emira Noumi, Nasrin E Khalifa, Mohamed A M Gad-Elkareem, Kaïss Aouadi, Adel Kadri. Repurposing of anisomycin and oleandomycin as a potential anti-(SARS-CoV-2) virus targeting key enzymes using virtual computational approaches. Cellular and molecular biology (Noisy-le-Grand, France). 2022 Feb; 67(5):387-398. doi: 10.14715/cmb/2021.67.5.51. [PMID: 35818229]
  • Wei Chen, Wenjing Yang, Chunyan Zhang, Te Liu, Jie Zhu, Hao Wang, Tong Li, Anli Jin, Lin Ding, Jingrong Xian, Tongtong Tian, Baishen Pan, Wei Guo, Beili Wang. Modulation of the p38 MAPK Pathway by Anisomycin Promotes Ferroptosis of Hepatocellular Carcinoma through Phosphorylation of H3S10. Oxidative medicine and cellular longevity. 2022; 2022(?):6986445. doi: 10.1155/2022/6986445. [PMID: 36466092]
  • Xiaoli Yin, Xueqi Zhuang, Weitao Luo, Meiqiu Liao, Lin Huang, Qiqian Cui, Jiayi Huang, Chunxia Yan, Zixiang Jiang, Yuan Liu, Weina Wang. Andrographolide promote the growth and immunity of Litopenaeus vannamei, and protects shrimps against Vibrio alginolyticus by regulating inflammation and apoptosis via a ROS-JNK dependent pathway. Frontiers in immunology. 2022; 13(?):990297. doi: 10.3389/fimmu.2022.990297. [PMID: 36159825]
  • Dušica M Kočović, Danica Bajuk-Bogdanović, Ilinka Pećinar, Biljana Božić Nedeljković, Marko Daković, Pavle R Andjus. Assessment of cellular and molecular changes in the rat brain after gamma radiation and radioprotection by anisomycin. Journal of radiation research. 2021 Sep; 62(5):793-803. doi: 10.1093/jrr/rrab045. [PMID: 34062561]
  • Takahiro Konuma, Kotaro Ogawa, Yukinori Okada. Integration of genetically regulated gene expression and pharmacological library provides therapeutic drug candidates. Human molecular genetics. 2021 04; 30(3-4):294-304. doi: 10.1093/hmg/ddab049. [PMID: 33577681]
  • Jinyu Li, Qi Sun, Chenying Zheng, Chunxiao Bai, Chuyin Liu, Xueqian Zhao, Peiying Deng, Limin Chai, Yusong Jia. Lipoxin A4-Mediated p38 MAPK Signaling Pathway Protects Mice Against Collagen-Induced Arthritis. Biochemical genetics. 2021 Feb; 59(1):346-365. doi: 10.1007/s10528-020-10016-9. [PMID: 33221976]
  • Guohua Huang, Jinwei Su, Wenqu Zhao, Zhixuan Deng, Ping Wang, Hangming Dong, Haijin Zhao, Shaoxi Cai. JNK modulates RAGE/β-catenin signaling and is essential for allergic airway inflammation in asthma. Toxicology letters. 2021 Jan; 336(?):57-67. doi: 10.1016/j.toxlet.2020.10.002. [PMID: 33075463]
  • Sezen Meydan, Nicholas R Guydosh. Disome and Trisome Profiling Reveal Genome-wide Targets of Ribosome Quality Control. Molecular cell. 2020 08; 79(4):588-602.e6. doi: 10.1016/j.molcel.2020.06.010. [PMID: 32615089]
  • Liz G Müller, Caroline Biojone, Amanda J Sales, Andresa H Betti, Vivian Herzfeldt, Sâmia R L Joca, Stela M K Rates. A valepotriate-enriched fraction from Valeriana glechomifolia decreases DNA methylation and up-regulate TrkB receptors in the hippocampus of mice. Behavioural pharmacology. 2020 06; 31(4):333-342. doi: 10.1097/fbp.0000000000000534. [PMID: 31860564]
  • Weiping Ye, Zhentian Ni, Shen Yicheng, Hao Pan, Yongyi Huang, Ying Xiong, Te Liu. Anisomycin inhibits angiogenesis in ovarian cancer by attenuating the molecular sponge effect of the lncRNA‑Meg3/miR‑421/PDGFRA axis. International journal of oncology. 2019 Dec; 55(6):1296-1312. doi: 10.3892/ijo.2019.4887. [PMID: 31638182]
  • Fernanda Malhão, Alice A Ramos, Suradet Buttachon, Tida Dethoup, Anake Kijjoa, Eduardo Rocha. Cytotoxic and Antiproliferative Effects of Preussin, a Hydroxypyrrolidine Derivative from the Marine Sponge-Associated Fungus Aspergillus candidus KUFA 0062, in a Panel of Breast Cancer Cell Lines and Using 2D and 3D Cultures. Marine drugs. 2019 Jul; 17(8):. doi: 10.3390/md17080448. [PMID: 31366127]
  • Yu-Feng Shen, Yang Hu, Bin Zhu, Gao-Xue Wang. Antiviral activity of anisomycin against spring viraemia of carp virus in epithelioma papulosum cyprini cells and zebrafish. Virus research. 2019 07; 268(?):38-44. doi: 10.1016/j.virusres.2019.05.013. [PMID: 31136824]
  • Suradet Buttachon, Alice A Ramos, Ângela Inácio, Tida Dethoup, Luís Gales, Michael Lee, Paulo M Costa, Artur M S Silva, Nazim Sekeroglu, Eduardo Rocha, Madalena M M Pinto, José A Pereira, Anake Kijjoa. Bis-Indolyl Benzenoids, Hydroxypyrrolidine Derivatives and Other Constituents from Cultures of the Marine Sponge-Associated Fungus Aspergillus candidus KUFA0062. Marine drugs. 2018 Apr; 16(4):. doi: 10.3390/md16040119. [PMID: 29642369]
  • Yuhui Hao, Rui Gao, Binghui Lu, Yonghong Ran, Zhangyou Yang, Jing Liu, Rong Li. Ghrelin protects against depleted uranium-induced bone damage by increasing osteoprotegerin/RANKL ratio. Toxicology and applied pharmacology. 2018 03; 343(?):62-70. doi: 10.1016/j.taap.2018.02.015. [PMID: 29477364]
  • Christine Wenz, Dagmar Faust, Berenike Linz, Christian Turmann, Teodora Nikolova, John Bertin, Peter Gough, Peter Wipf, Anna Sophia Schröder, Stefan Krautwald, Cornelia Dietrich. t-BuOOH induces ferroptosis in human and murine cell lines. Archives of toxicology. 2018 Feb; 92(2):759-775. doi: 10.1007/s00204-017-2066-y. [PMID: 28975372]
  • Nayeli Jiménez-Morales, Karina Mendoza-Ángeles, Mercedes Porras-Villalobos, Elizabeth Ibarra-Coronado, Gabriel Roldán-Roldán, Jesús Hernández-Falcón. Who is the boss? Individual recognition memory and social hierarchy formation in crayfish. Neurobiology of learning and memory. 2018 01; 147(?):79-89. doi: 10.1016/j.nlm.2017.11.017. [PMID: 29198599]
  • Chuanhua Cao, Haiying Yu, Feng Wu, Huixiong Qi, Jingbo He. Antibiotic anisomycin induces cell cycle arrest and apoptosis through inhibiting mitochondrial biogenesis in osteosarcoma. Journal of bioenergetics and biomembranes. 2017 Dec; 49(6):437-443. doi: 10.1007/s10863-017-9734-8. [PMID: 29164469]
  • Zixian Jiao, Weifeng Xu, Jisi Zheng, Pei Shen, An Qin, Shanyong Zhang, Chi Yang. Kaempferide Prevents Titanium Particle Induced Osteolysis by Suppressing JNK Activation during Osteoclast Formation. Scientific reports. 2017 11; 7(1):16665. doi: 10.1038/s41598-017-16853-w. [PMID: 29192233]
  • Chien-An Chen, Chien-Kuo Liu, Ming-Ling Hsu, Chih-Wen Chi, Chun-Chuan Ko, Jian-Syun Chen, Cheng-Ta Lai, Hen-Hong Chang, Tzung-Yan Lee, Yuen-Liang Lai, Yu-Jen Chen. Daphnoretin modulates differentiation and maturation of human dendritic cells through down-regulation of c-Jun N-terminal kinase. International immunopharmacology. 2017 Oct; 51(?):25-30. doi: 10.1016/j.intimp.2017.07.021. [PMID: 28772243]
  • Yongnan Li, Xiuxian Wu, Xinghua Jin, Jiumei Wang, Yoshikazu Togo, Toru Suzuki, Takahiko Hashimoto, Yusuke Yamada, Yukako Nakanishi, Akihiro Kanematsu, Michio Nojima, Yoshiyuki Kakehi, Shingo Yamamoto. Enhancement of death receptor 4-mediated apoptosis and cytotoxicity in renal cell carcinoma cells by anisomycin. Anti-cancer drugs. 2017 02; 28(2):180-186. doi: 10.1097/cad.0000000000000450. [PMID: 27879498]
  • Shuqing Chen, Yongqian Wang, Yubin Yang, Ting Xiang, Jiahui Liu, Houming Zhou, Xinlin Wu. Psoralen Inhibited Apoptosis of Osteoporotic Osteoblasts by Modulating IRE1-ASK1-JNK Pathway. BioMed research international. 2017; 2017(?):3524307. doi: 10.1155/2017/3524307. [PMID: 28349059]
  • Jiao Feng, Qinghui Zhang, Wenhui Mo, Liwei Wu, Sainan Li, Jingjing Li, Tong Liu, Shizan Xu, Xiaoming Fan, Chuanyong Guo. Salidroside pretreatment attenuates apoptosis and autophagy during hepatic ischemia-reperfusion injury by inhibiting the mitogen-activated protein kinase pathway in mice. Drug design, development and therapy. 2017; 11(?):1989-2006. doi: 10.2147/dddt.s136792. [PMID: 28721018]
  • David Levitan, Yaihara Fortis-Santiago, Joshua A Figueroa, Emily E Reid, Takashi Yoshida, Nicholas C Barry, Abigail Russo, Donald B Katz. Memory Retrieval Has a Dynamic Influence on the Maintenance Mechanisms That Are Sensitive to ζ-Inhibitory Peptide (ZIP). The Journal of neuroscience : the official journal of the Society for Neuroscience. 2016 10; 36(41):10654-10662. doi: 10.1523/jneurosci.1568-16.2016. [PMID: 27733615]
  • Qing Chen, Xinghui Liu, Limin Xu, Ying Wang, Suwei Wang, Qiong Li, Yongyi Huang, Te Liu. Long non-coding RNA BACE1-AS is a novel target for anisomycin-mediated suppression of ovarian cancer stem cell proliferation and invasion. Oncology reports. 2016 Apr; 35(4):1916-24. doi: 10.3892/or.2016.4571. [PMID: 26783004]
  • Tushar B Deb, Robert J Barndt, Annie H Zuo, Surojeet Sengupta, Christine M Coticchia, Michael D Johnson. PTEN-mediated ERK1/2 inhibition and paradoxical cellular proliferation following Pnck overexpression. Cell cycle (Georgetown, Tex.). 2014; 13(6):961-73. doi: 10.4161/cc.27837. [PMID: 24552815]
  • Zhenni Zhang, Jianrui Lv, Xiaoming Lei, Siyuan Li, Yong Zhang, Lihua Meng, Rongliang Xue, Zongfang Li. Baicalein reduces the invasion of glioma cells via reducing the activity of p38 signaling pathway. PloS one. 2014; 9(2):e90318. doi: 10.1371/journal.pone.0090318. [PMID: 24587321]
  • Bo Ram Seo, Kyoung-Jin Min, Shin Kim, Jong-Wook Park, Won-Kyun Park, Tae-Jin Lee, Taeg Kyu Kwon. Anisomycin treatment enhances TRAIL-mediated apoptosis in renal carcinoma cells through the down-regulation of Bcl-2, c-FLIP(L) and Mcl-1. Biochimie. 2013 Apr; 95(4):858-65. doi: 10.1016/j.biochi.2012.12.002. [PMID: 23261849]
  • A N Kukushkin, S B Svetlikova, V A Pospelov. [Protein phosphatase MKP-1 participates in c-fos gene derepression under the action of stress factors on fibroblasts transformed with E1A and cHA-ras oncogenes]. Tsitologiia. 2013; 55(12):861-7. doi: . [PMID: 25474904]
  • Shuang Mei, Haihua Gu, Adam Ward, Xuefeng Yang, Huailan Guo, Ka He, Zhenqi Liu, Wenhong Cao. p38 mitogen-activated protein kinase (MAPK) promotes cholesterol ester accumulation in macrophages through inhibition of macroautophagy. The Journal of biological chemistry. 2012 Apr; 287(15):11761-8. doi: 10.1074/jbc.m111.333575. [PMID: 22354961]
  • Eduard Sarró, Conxita Jacobs-Cachá, Emilio Itarte, Anna Meseguer. A pharmacologically-based array to identify targets of cyclosporine A-induced toxicity in cultured renal proximal tubule cells. Toxicology and applied pharmacology. 2012 Jan; 258(2):275-87. doi: 10.1016/j.taap.2011.11.007. [PMID: 22155090]
  • Zhengle Tang, Feiyue Xing, Di Chen, Yu Yu, Chunyan Yu, Jingfang Di, Jing Liu. In vivo toxicological evaluation of Anisomycin. Toxicology letters. 2012 Jan; 208(1):1-11. doi: 10.1016/j.toxlet.2011.10.001. [PMID: 22004851]
  • Teruo Shimmen. Involvement of protein synthesis in recovery from refractory period of electrical depolarization induced by osmotic stimulation in Chara corallina. Journal of plant research. 2011 Sep; 124(5):639-44. doi: 10.1007/s10265-010-0391-9. [PMID: 21104191]
  • Keren Weidenfeld-Baranboim, Lilach Koren, Ami Aronheim. Phosphorylation of JDP2 on threonine-148 by the c-Jun N-terminal kinase targets it for proteosomal degradation. The Biochemical journal. 2011 Jun; 436(3):661-9. doi: 10.1042/bj20101031. [PMID: 21463260]
  • N Ronkina, M B Menon, J Schwermann, J S C Arthur, H Legault, J-B Telliez, U S Kayyali, A R Nebreda, A Kotlyarov, M Gaestel. Stress induced gene expression: a direct role for MAPKAP kinases in transcriptional activation of immediate early genes. Nucleic acids research. 2011 Apr; 39(7):2503-18. doi: 10.1093/nar/gkq1178. [PMID: 21109534]
  • Jianjun Guo, Shucai Wang, Oliver Valerius, Hardy Hall, Qingning Zeng, Jian-Feng Li, David J Weston, Brian E Ellis, Jin-Gui Chen. Involvement of Arabidopsis RACK1 in protein translation and its regulation by abscisic acid. Plant physiology. 2011 Jan; 155(1):370-83. doi: 10.1104/pp.110.160663. [PMID: 21098678]
  • Kirandeep Kaur, Meenakshi Jain, Tarandeep Kaur, Rahul Jain. Antimalarials from nature. Bioorganic & medicinal chemistry. 2009 May; 17(9):3229-56. doi: 10.1016/j.bmc.2009.02.050. [PMID: 19299148]
  • Marianna Pap, József Szeberényi. Involvement of proteolytic activation of protein kinase R in the apoptosis of PC12 pheochromocytoma cells. Cellular and molecular neurobiology. 2008 May; 28(3):443-56. doi: 10.1007/s10571-007-9245-y. [PMID: 18080832]
  • Claire Diradourian, Cédric Le May, Michèle Caüzac, Jean Girard, Anne-Françoise Burnol, Jean-Paul Pégorier. Involvement of ZIP/p62 in the regulation of PPARalpha transcriptional activity by p38-MAPK. Biochimica et biophysica acta. 2008 May; 1781(5):239-44. doi: 10.1016/j.bbalip.2008.02.002. [PMID: 18374665]
  • Yen-Chuan Ou, Chi-Rei Yang, Chen-Li Cheng, Shue-Ling Raung, Yu-Yeh Hung, Chun-Jung Chen. Indomethacin induces apoptosis in 786-O renal cell carcinoma cells by activating mitogen-activated protein kinases and AKT. European journal of pharmacology. 2007 Jun; 563(1-3):49-60. doi: 10.1016/j.ejphar.2007.01.071. [PMID: 17341418]
  • Soon Young Shin, Joon Ho Lee, Byung Min, Young Han Lee. The translation inhibitor anisomycin induces Elk-1-mediated transcriptional activation of egr-1 through multiple mitogen-activated protein kinase pathways. Experimental & molecular medicine. 2006 Dec; 38(6):677-85. doi: 10.1038/emm.2006.80. [PMID: 17202844]
  • Sandra Ross, Teresa Chen, Violeta Yu, Yanyan Tudor, Dawei Zhang, Longbin Liu, Nuria Tamayo, Celia Dominguez, David Powers. High-content screening analysis of the p38 pathway: profiling of structurally related p38alpha kinase inhibitors using cell-based assays. Assay and drug development technologies. 2006 Aug; 4(4):397-409. doi: 10.1089/adt.2006.4.397. [PMID: 16945013]
  • M S Abramova, A A Moskvitin, A S Pivovarov. [Effect of protein synthesis inhibitors on sensitization of defence reaction and on cholinosensitivity of command neurons in Helix lucorum]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. 2006 May; 56(3):355-62. doi: ". [PMID: 16869270]
  • Xiaobiao Wang, Hiroto Mizushima, Satoshi Adachi, Minako Ohishi, Ryo Iwamoto, Eisuke Mekada. Cytoplasmic domain phosphorylation of heparin-binding EGF-like growth factor. Cell structure and function. 2006; 31(1):15-27. doi: 10.1247/csf.31.15. [PMID: 16557002]
  • Sophie Turban, Victoria A Beardmore, Julia M Carr, Kei Sakamoto, Eric Hajduch, J Simon C Arthur, Harinder S Hundal. Insulin-stimulated glucose uptake does not require p38 mitogen-activated protein kinase in adipose tissue or skeletal muscle. Diabetes. 2005 Nov; 54(11):3161-8. doi: 10.2337/diabetes.54.11.3161. [PMID: 16249440]
  • Lin Xiao, Aiqun Qi, Yizhang Chen. Cultured embryonic hippocampal neurons deficient in glucocorticoid (GC) receptor: a novel model for studying nongenomic effects of GC in the neural system. Endocrinology. 2005 Sep; 146(9):4036-41. doi: 10.1210/en.2004-1652. [PMID: 15961565]
  • Robert S Kiss, Jovana Maric, Yves L Marcel. Lipid efflux in human and mouse macrophagic cells: evidence for differential regulation of phospholipid and cholesterol efflux. Journal of lipid research. 2005 Sep; 46(9):1877-87. doi: 10.1194/jlr.m400482-jlr200. [PMID: 15995179]
  • Ellen K Wittmack, Anthony M Rush, Andy Hudmon, Stephen G Waxman, Sulayman D Dib-Hajj. Voltage-gated sodium channel Nav1.6 is modulated by p38 mitogen-activated protein kinase. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005 Jul; 25(28):6621-30. doi: 10.1523/jneurosci.0541-05.2005. [PMID: 16014723]
  • Ai-Qun Qi, Jian Qiu, Lin Xiao, Yi-Zhang Chen. Rapid activation of JNK and p38 by glucocorticoids in primary cultured hippocampal cells. Journal of neuroscience research. 2005 May; 80(4):510-7. doi: 10.1002/jnr.20491. [PMID: 15846779]
  • Cary Boyd, Anikó Náray-Fejes-Tóth. Gene regulation of ENaC subunits by serum- and glucocorticoid-inducible kinase-1. American journal of physiology. Renal physiology. 2005 Mar; 288(3):F505-12. doi: 10.1152/ajprenal.00242.2004. [PMID: 15536167]
  • Laura S J von Hertzen, K Peter Giese. Memory reconsolidation engages only a subset of immediate-early genes induced during consolidation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005 Feb; 25(8):1935-42. doi: 10.1523/jneurosci.4707-04.2005. [PMID: 15728833]
  • Rania Nasrallah, Richard L Hébert. Reduced IP receptors in STZ-induced diabetic rat kidneys and high-glucose-treated mesangial cells. American journal of physiology. Renal physiology. 2004 Oct; 287(4):F673-81. doi: 10.1152/ajprenal.00025.2004. [PMID: 15161601]
  • Carlos E Marroquin, Laura Downey, Hongtao Guo, Paul C Kuo. Osteopontin increases CD44 expression and cell adhesion in RAW 264.7 murine leukemia cells. Immunology letters. 2004 Aug; 95(1):109-12. doi: 10.1016/j.imlet.2004.06.001. [PMID: 15325806]
  • Ryuichi Mizuno, Mototsugu Oya, Takayuki Shiomi, Ken Marumo, Yasunori Okada, Masaru Murai. Inhibition of MKP-1 expression potentiates JNK related apoptosis in renal cancer cells. The Journal of urology. 2004 Aug; 172(2):723-7. doi: 10.1097/01.ju.0000124990.37563.00. [PMID: 15247770]
  • Hidenori Taru, Toshiharu Suzuki. Facilitation of stress-induced phosphorylation of beta-amyloid precursor protein family members by X11-like/Mint2 protein. The Journal of biological chemistry. 2004 May; 279(20):21628-36. doi: 10.1074/jbc.m312007200. [PMID: 14970211]
  • Guohai Wu, Albert J Robertson, Xunjia Liu, Ping Zheng, Ronald W Wilen, Nicole T Nesbitt, Lawrence V Gusta. A lipid transfer protein gene BG-14 is differentially regulated by abiotic stress, ABA, anisomycin, and sphingosine in bromegrass (Bromus inermis). Journal of plant physiology. 2004 Apr; 161(4):449-58. doi: 10.1078/0176-1617-01259. [PMID: 15128032]
  • Jerzy-Roch Nofer, Renata Feuerborn, Bodo Levkau, Andrea Sokoll, Udo Seedorf, Gerd Assmann. Involvement of Cdc42 signaling in apoA-I-induced cholesterol efflux. The Journal of biological chemistry. 2003 Dec; 278(52):53055-62. doi: 10.1074/jbc.m305673200. [PMID: 14563854]
  • Jean-Philippe Fortin, Johanne Bouthillier, François Marceau. High agonist-independent clearance of rabbit kinin B1 receptors in cultured cells. American journal of physiology. Heart and circulatory physiology. 2003 May; 284(5):H1647-54. doi: 10.1152/ajpheart.00884.2002. [PMID: 12521931]
  • Yong Li, Ken Inoki, Panayiotis Vacratsis, Kun-Liang Guan. The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3. The Journal of biological chemistry. 2003 Apr; 278(16):13663-71. doi: 10.1074/jbc.m300862200. [PMID: 12582162]
  • Nobuo Watanabe, Takeo Iwamoto, Kathy D Bowen, Dale A Dickinson, Martine Torres, Henry Jay Forman. Bio-effectiveness of Tat-catalase conjugate: a potential tool for the identification of H2O2-dependent cellular signal transduction pathways. Biochemical and biophysical research communications. 2003 Mar; 303(1):287-93. doi: 10.1016/s0006-291x(03)00335-8. [PMID: 12646200]
  • Magali Bébien, Sara Salinas, Carine Becamel, Véronique Richard, Laetitia Linares, Robert A Hipskind. Immediate-early gene induction by the stresses anisomycin and arsenite in human osteosarcoma cells involves MAPK cascade signaling to Elk-1, CREB and SRF. Oncogene. 2003 Mar; 22(12):1836-47. doi: 10.1038/sj.onc.1206334. [PMID: 12660819]
  • R John MacLeod, Naibedya Chattopadhyay, Edward M Brown. PTHrP stimulated by the calcium-sensing receptor requires MAP kinase activation. American journal of physiology. Endocrinology and metabolism. 2003 Feb; 284(2):E435-42. doi: 10.1152/ajpendo.00143.2002. [PMID: 12388158]
  • Kerstin Leykauf, Matthias Dürst, Angel Alonso. Phosphorylation and subcellular distribution of connexin43 in normal and stressed cells. Cell and tissue research. 2003 Jan; 311(1):23-30. doi: 10.1007/s00441-002-0645-5. [PMID: 12483281]
  • R Caricchio, L D'Adamio, P L Cohen. Fas, ceramide and serum withdrawal induce apoptosis via a common pathway in a type II Jurkat cell line. Cell death and differentiation. 2002 May; 9(5):574-80. doi: 10.1038/sj.cdd.4400996. [PMID: 11973615]
  • V Poindessous-Jazat, Y Augery-Bourget, J Robert-Lézénès. C-Jun modulates apoptosis but not terminal cell differentiation in murine erythroleukemia cells. Leukemia. 2002 Feb; 16(2):233-43. doi: 10.1038/sj.leu.2402350. [PMID: 11840290]
  • Ralph G Meyer, Jan-Heiner Küpper, Reinhard Kandolf, H Peter Rodemann. Early growth response-1 gene (Egr-1) promoter induction by ionizing radiation in U87 malignant glioma cells in vitro. European journal of biochemistry. 2002 Jan; 269(1):337-46. doi: 10.1046/j.0014-2956.2001.02658.x. [PMID: 11784328]
  • Tracey L Mynott, Ben Crossett, S Radhika Prathalingam. Proteolytic inhibition of Salmonella enterica serovar typhimurium-induced activation of the mitogen-activated protein kinases ERK and JNK in cultured human intestinal cells. Infection and immunity. 2002 Jan; 70(1):86-95. doi: 10.1128/iai.70.1.86-95.2002. [PMID: 11748167]
  • J H Ahn, S M Park, H S Cho, M S Lee, J B Yoon, J Vilcek, T H Lee. Non-apoptotic signaling pathways activated by soluble Fas ligand in serum-starved human fibroblasts. Mitogen-activated protein kinases and NF-kappaB-dependent gene expression. The Journal of biological chemistry. 2001 Dec; 276(50):47100-6. doi: 10.1074/jbc.m107385200. [PMID: 11600497]
  • K Uchida, H Suzuki, T Ohashi, K Nitta, W Yumura, H Nihei. Involvement of MAP kinase cascades in Smad7 transcriptional regulation. Biochemical and biophysical research communications. 2001 Nov; 289(2):376-81. doi: 10.1006/bbrc.2001.5984. [PMID: 11716483]
  • B Mograbi, R Bocciardi, I Bourget, T Juhel, D Farahi-Far, G Romeo, I Ceccherini, B Rossi. The sensitivity of activated Cys Ret mutants to glial cell line-derived neurotrophic factor is mandatory to rescue neuroectodermic cells from apoptosis. Molecular and cellular biology. 2001 Oct; 21(20):6719-30. doi: 10.1128/mcb.21.20.6719-6730.2001. [PMID: 11564857]
  • M F Santiago, P López-Aparicio, M N Recio, M A Pérez-Albarsanz. Redistribution of cPLA(2) in rat renal tubular cell cultures in response to PCBs. Cellular signalling. 2001 Feb; 13(2):111-8. doi: 10.1016/s0898-6568(00)00148-0. [PMID: 11257455]
  • R Kawazoe, S Hwang, D L Herrin. Requirement for cytoplasmic protein synthesis during circadian peaks of transcription of chloroplast-encoded genes in Chlamydomonas. Plant molecular biology. 2000 Dec; 44(6):699-709. doi: 10.1023/a:1026519718992. [PMID: 11202433]
  • M Takekawa, M Adachi, A Nakahata, I Nakayama, F Itoh, H Tsukuda, Y Taya, K Imai. p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation. The EMBO journal. 2000 Dec; 19(23):6517-26. doi: 10.1093/emboj/19.23.6517. [PMID: 11101524]
  • E T Coffey, V Hongisto, M Dickens, R J Davis, M J Courtney. Dual roles for c-Jun N-terminal kinase in developmental and stress responses in cerebellar granule neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2000 Oct; 20(20):7602-13. doi: 10.1523/jneurosci.20-20-07602.2000. [PMID: 11027220]
  • K C Chung, S M Kim, S Rhang, L F Lau, I Gomes, Y S Ahn. Expression of immediate early gene pip92 during anisomycin-induced cell death is mediated by the JNK- and p38-dependent activation of Elk1. European journal of biochemistry. 2000 Aug; 267(15):4676-84. doi: 10.1046/j.1432-1327.2000.01517.x. [PMID: 10903500]
  • K Wosikowski, J A Silverman, P Bishop, J Mendelsohn, S E Bates. Reduced growth rate accompanied by aberrant epidermal growth factor signaling in drug resistant human breast cancer cells. Biochimica et biophysica acta. 2000 Jul; 1497(2):215-26. doi: 10.1016/s0167-4889(00)00062-8. [PMID: 10903426]
  • R R Roussel, A Barchowsky. Arsenic inhibits NF-kappaB-mediated gene transcription by blocking IkappaB kinase activity and IkappaBalpha phosphorylation and degradation. Archives of biochemistry and biophysics. 2000 May; 377(1):204-12. doi: 10.1006/abbi.2000.1770. [PMID: 10775461]
  • S Waldegger, S Gabrysch, P Barth, S Fillon, F Lang. h-sgk serine-threonine protein kinase as transcriptional target of p38/MAP kinase pathway in HepG2 human hepatoma cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2000; 10(4):203-8. doi: 10.1159/000016351. [PMID: 11093030]
  • J V Cross, J C Deak, E A Rich, Y Qian, M Lewis, L A Parrott, K Mochida, D Gustafson, S Vande Pol, D J Templeton. Quinone reductase inhibitors block SAPK/JNK and NFkappaB pathways and potentiate apoptosis. The Journal of biological chemistry. 1999 Oct; 274(44):31150-4. doi: 10.1074/jbc.274.44.31150. [PMID: 10531305]
  • T Igishi, S Fukuhara, V Patel, B Z Katz, K M Yamada, J S Gutkind. Divergent signaling pathways link focal adhesion kinase to mitogen-activated protein kinase cascades. Evidence for a role of paxillin in c-Jun NH(2)-terminal kinase activation. The Journal of biological chemistry. 1999 Oct; 274(43):30738-46. doi: 10.1074/jbc.274.43.30738. [PMID: 10521463]
  • P Dhawan, A Bell, A Kumar, C Golden, K D Mehta. Critical role of p42/44(MAPK) activation in anisomycin and hepatocyte growth factor-induced LDL receptor expression: activation of Raf-1/Mek-1/p42/44(MAPK) cascade alone is sufficient to induce LDL receptor expression. Journal of lipid research. 1999 Oct; 40(10):1911-9. doi: . [PMID: 10508211]
  • C Ducret, S M Maira, A Dierich, B Wasylyk. The net repressor is regulated by nuclear export in response to anisomycin, UV, and heat shock. Molecular and cellular biology. 1999 Oct; 19(10):7076-87. doi: 10.1128/mcb.19.10.7076. [PMID: 10490644]
  • C S Fraser, V M Pain, S J Morley. Cellular stress in xenopus kidney cells enhances the phosphorylation of eukaryotic translation initiation factor (eIF)4E and the association of eIF4F with poly(A)-binding protein. The Biochemical journal. 1999 Sep; 342 Pt 3(?):519-26. doi: 10.1042/bj3420519. [PMID: 10477262]
  • I Demori, C Bottazzi, E Fugassa. Tri-iodothyronine increases insulin-like growth factor binding protein-2 expression in cultured hepatocytes from hypothyroid rats. The Journal of endocrinology. 1999 Jun; 161(3):465-74. doi: 10.1677/joe.0.1610465. [PMID: 10333549]
  • J D Watts, M Gu, S D Patterson, R Aebersold, A J Polverino. On the complexities of ceramide changes in cells undergoing apoptosis: lack of evidence for a second messenger function in apoptotic induction. Cell death and differentiation. 1999 Feb; 6(2):105-14. doi: 10.1038/sj.cdd.4400472. [PMID: 10200556]
  • T Yujiri, S Sather, G R Fanger, G L Johnson. Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption. Science (New York, N.Y.). 1998 Dec; 282(5395):1911-4. doi: 10.1126/science.282.5395.1911. [PMID: 9836645]
  • S Tsuruoka, G J Schwartz. Adaptation of the outer medullary collecting duct to metabolic acidosis in vitro. The American journal of physiology. 1998 12; 275(6):F982-90. doi: 10.1152/ajprenal.1998.275.6.f982. [PMID: 9843916]
  • S Duvet, O Labiau, A M Mir, D Kmiécik, S S Krag, A Verbert, R Cacan. Cytosolic deglycosylation process of newly synthesized glycoproteins generates oligomannosides possessing one GlcNAc residue at the reducing end. The Biochemical journal. 1998 Oct; 335 ( Pt 2)(?):389-96. doi: 10.1042/bj3350389. [PMID: 9761739]
  • Y Okubo, V A Blakesley, B Stannard, S Gutkind, D Le Roith. Insulin-like growth factor-I inhibits the stress-activated protein kinase/c-Jun N-terminal kinase. The Journal of biological chemistry. 1998 Oct; 273(40):25961-6. doi: 10.1074/jbc.273.40.25961. [PMID: 9748273]
  • X Wang, A Flynn, A J Waskiewicz, B L Webb, R G Vries, I A Baines, J A Cooper, C G Proud. The phosphorylation of eukaryotic initiation factor eIF4E in response to phorbol esters, cell stresses, and cytokines is mediated by distinct MAP kinase pathways. The Journal of biological chemistry. 1998 Apr; 273(16):9373-7. doi: 10.1074/jbc.273.16.9373. [PMID: 9545260]
  • S Unchern, H Saito, N Nishiyama. Death of cerebellar granule neurons induced by piperine is distinct from that induced by low potassium medium. Neurochemical research. 1998 Jan; 23(1):97-102. doi: 10.1023/a:1022461706344. [PMID: 9482273]
  • L F Barros, M Young, J Saklatvala, S A Baldwin. Evidence of two mechanisms for the activation of the glucose transporter GLUT1 by anisomycin: p38(MAP kinase) activation and protein synthesis inhibition in mammalian cells. The Journal of physiology. 1997 Nov; 504 ( Pt 3)(?):517-25. doi: 10.1111/j.1469-7793.1997.517bd.x. [PMID: 9401960]
  • S J Morley, L McKendrick. Involvement of stress-activated protein kinase and p38/RK mitogen-activated protein kinase signaling pathways in the enhanced phosphorylation of initiation factor 4E in NIH 3T3 cells. The Journal of biological chemistry. 1997 Jul; 272(28):17887-93. doi: 10.1074/jbc.272.28.17887. [PMID: 9211946]
  • S Itoh, Y Kameda, E Yamada, K Tsujikawa, T Mimura, Y Kohama. Molecular cloning and characterization of a novel putative STE20-like kinase in guinea pigs. Archives of biochemistry and biophysics. 1997 Apr; 340(2):201-7. doi: 10.1006/abbi.1997.9893. [PMID: 9143322]
  • H Schramek, M Schumacher, D Wilflingseder, H Oberleithner, W Pfaller. Differential expression and activation of MAP kinases in dedifferentiated MDCK-focus cells. The American journal of physiology. 1997 Feb; 272(2 Pt 1):C383-91. doi: 10.1152/ajpcell.1997.272.2.c383. [PMID: 9124279]
  • J J Sheu, T S Yu, W F Tong, S M Yu. Carbohydrate starvation stimulates differential expression of rice alpha-amylase genes that is modulated through complicated transcriptional and posttranscriptional processes. The Journal of biological chemistry. 1996 Oct; 271(43):26998-7004. doi: 10.1074/jbc.271.43.26998. [PMID: 8900187]
  • H Kawasaki, T Moriguchi, S Matsuda, H Z Li, S Nakamura, S Shimohama, J Kimura, Y Gotoh, E Nishida. Ras-dependent and Ras-independent activation pathways for the stress-activated-protein-kinase cascade. European journal of biochemistry. 1996 Oct; 241(2):315-21. doi: 10.1111/j.1432-1033.1996.00315.x. [PMID: 8917425]