Anisomycin (BioDeep_00000003605)

   

natural product Chemicals and Drugs Volatile Flavor Compounds


代谢物信息卡片


Flagecidin;Wuningmeisu C

化学式: C14H19NO4 (265.1314014)
中文名称: 茴香霉素
谱图信息: 最多检出来源 Viridiplantae(plant) 0.77%

分子结构信息

SMILES: CC(=O)OC1C(CNC1CC2=CC=C(C=C2)OC)O
InChI: InChI=1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3

描述信息

An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
D004791 - Enzyme Inhibitors > D011500 - Protein Synthesis Inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
C254 - Anti-Infective Agent > C258 - Antibiotic
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.392
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.387
Anisomycin is a potent protein synthesis inhibitor which interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system[1]. Anisomycin is a JNK activator, which increases phospho-JNK[2][3]. Anisomycin is a bacterial antibiotic[4].

同义名列表

6 个代谢物同义名

(-)-anisomycin; Anisomycin; Flagecidin;Wuningmeisu C; Flagecidin; Wuningmeisu C; Anisomycin



数据库引用编号

42 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jing Shu, Kexin Cao, Chuanjiang Fei, Hui Dai, Yuhang Li, Yi Cao, Tao Zhou, Miao Yu, Zihao Xia, Mengnan An, Yuanhua Wu. Antiviral Mechanisms of Anisomycin Produced by Streptomyces albulus SN40 on Potato Virus Y. Journal of agricultural and food chemistry. 2024 Feb; 72(7):3506-3519. doi: 10.1021/acs.jafc.3c07732. [PMID: 38346922]
  • Lele Ling, Yichao Wen, Ying Xiong, Xin Liu, Juan Chen, Te Liu, Bimeng Zhang. Anisomycin inhibits the activity of human ovarian cancer stem cells via regulating antisense RNA NCPB2-AS2/MEK/ERK/STAT3 signaling. The journal of gene medicine. 2023 Jul; ?(?):e3571. doi: 10.1002/jgm.3571. [PMID: 37483091]
  • Can-Can Zhou, Yu-Qiong He, Yu-Shuang Qiu, Chen-Xu Ni, Fu-Ming Shen, Dong-Jie Li. Zinc supplementation ameliorates sorafenib-induced cognitive impairment through ROS/JNK signaling pathway. Biological trace element research. 2023 Jan; 201(1):324-337. doi: 10.1007/s12011-022-03142-5. [PMID: 35129807]
  • Rafat Zrieq, Mejdi Snoussi, Fahad D Algahtan, Munazzah Tasleem, Mohd Saeed, Emira Noumi, Nasrin E Khalifa, Mohamed A M Gad-Elkareem, Kaïss Aouadi, Adel Kadri. Repurposing of anisomycin and oleandomycin as a potential anti-(SARS-CoV-2) virus targeting key enzymes using virtual computational approaches. Cellular and molecular biology (Noisy-le-Grand, France). 2022 Feb; 67(5):387-398. doi: 10.14715/cmb/2021.67.5.51. [PMID: 35818229]
  • Wei Chen, Wenjing Yang, Chunyan Zhang, Te Liu, Jie Zhu, Hao Wang, Tong Li, Anli Jin, Lin Ding, Jingrong Xian, Tongtong Tian, Baishen Pan, Wei Guo, Beili Wang. Modulation of the p38 MAPK Pathway by Anisomycin Promotes Ferroptosis of Hepatocellular Carcinoma through Phosphorylation of H3S10. Oxidative medicine and cellular longevity. 2022; 2022(?):6986445. doi: 10.1155/2022/6986445. [PMID: 36466092]
  • Xiaoli Yin, Xueqi Zhuang, Weitao Luo, Meiqiu Liao, Lin Huang, Qiqian Cui, Jiayi Huang, Chunxia Yan, Zixiang Jiang, Yuan Liu, Weina Wang. Andrographolide promote the growth and immunity of Litopenaeus vannamei, and protects shrimps against Vibrio alginolyticus by regulating inflammation and apoptosis via a ROS-JNK dependent pathway. Frontiers in immunology. 2022; 13(?):990297. doi: 10.3389/fimmu.2022.990297. [PMID: 36159825]
  • Dušica M Kočović, Danica Bajuk-Bogdanović, Ilinka Pećinar, Biljana Božić Nedeljković, Marko Daković, Pavle R Andjus. Assessment of cellular and molecular changes in the rat brain after gamma radiation and radioprotection by anisomycin. Journal of radiation research. 2021 Sep; 62(5):793-803. doi: 10.1093/jrr/rrab045. [PMID: 34062561]
  • Takahiro Konuma, Kotaro Ogawa, Yukinori Okada. Integration of genetically regulated gene expression and pharmacological library provides therapeutic drug candidates. Human molecular genetics. 2021 04; 30(3-4):294-304. doi: 10.1093/hmg/ddab049. [PMID: 33577681]
  • Jinyu Li, Qi Sun, Chenying Zheng, Chunxiao Bai, Chuyin Liu, Xueqian Zhao, Peiying Deng, Limin Chai, Yusong Jia. Lipoxin A4-Mediated p38 MAPK Signaling Pathway Protects Mice Against Collagen-Induced Arthritis. Biochemical genetics. 2021 Feb; 59(1):346-365. doi: 10.1007/s10528-020-10016-9. [PMID: 33221976]
  • Guohua Huang, Jinwei Su, Wenqu Zhao, Zhixuan Deng, Ping Wang, Hangming Dong, Haijin Zhao, Shaoxi Cai. JNK modulates RAGE/β-catenin signaling and is essential for allergic airway inflammation in asthma. Toxicology letters. 2021 Jan; 336(?):57-67. doi: 10.1016/j.toxlet.2020.10.002. [PMID: 33075463]
  • Sezen Meydan, Nicholas R Guydosh. Disome and Trisome Profiling Reveal Genome-wide Targets of Ribosome Quality Control. Molecular cell. 2020 08; 79(4):588-602.e6. doi: 10.1016/j.molcel.2020.06.010. [PMID: 32615089]
  • Liz G Müller, Caroline Biojone, Amanda J Sales, Andresa H Betti, Vivian Herzfeldt, Sâmia R L Joca, Stela M K Rates. A valepotriate-enriched fraction from Valeriana glechomifolia decreases DNA methylation and up-regulate TrkB receptors in the hippocampus of mice. Behavioural pharmacology. 2020 06; 31(4):333-342. doi: 10.1097/fbp.0000000000000534. [PMID: 31860564]
  • Weiping Ye, Zhentian Ni, Shen Yicheng, Hao Pan, Yongyi Huang, Ying Xiong, Te Liu. Anisomycin inhibits angiogenesis in ovarian cancer by attenuating the molecular sponge effect of the lncRNA‑Meg3/miR‑421/PDGFRA axis. International journal of oncology. 2019 Dec; 55(6):1296-1312. doi: 10.3892/ijo.2019.4887. [PMID: 31638182]
  • Fernanda Malhão, Alice A Ramos, Suradet Buttachon, Tida Dethoup, Anake Kijjoa, Eduardo Rocha. Cytotoxic and Antiproliferative Effects of Preussin, a Hydroxypyrrolidine Derivative from the Marine Sponge-Associated Fungus Aspergillus candidus KUFA 0062, in a Panel of Breast Cancer Cell Lines and Using 2D and 3D Cultures. Marine drugs. 2019 Jul; 17(8):. doi: 10.3390/md17080448. [PMID: 31366127]
  • Yu-Feng Shen, Yang Hu, Bin Zhu, Gao-Xue Wang. Antiviral activity of anisomycin against spring viraemia of carp virus in epithelioma papulosum cyprini cells and zebrafish. Virus research. 2019 07; 268(?):38-44. doi: 10.1016/j.virusres.2019.05.013. [PMID: 31136824]
  • Suradet Buttachon, Alice A Ramos, Ângela Inácio, Tida Dethoup, Luís Gales, Michael Lee, Paulo M Costa, Artur M S Silva, Nazim Sekeroglu, Eduardo Rocha, Madalena M M Pinto, José A Pereira, Anake Kijjoa. Bis-Indolyl Benzenoids, Hydroxypyrrolidine Derivatives and Other Constituents from Cultures of the Marine Sponge-Associated Fungus Aspergillus candidus KUFA0062. Marine drugs. 2018 Apr; 16(4):. doi: 10.3390/md16040119. [PMID: 29642369]
  • Yuhui Hao, Rui Gao, Binghui Lu, Yonghong Ran, Zhangyou Yang, Jing Liu, Rong Li. Ghrelin protects against depleted uranium-induced bone damage by increasing osteoprotegerin/RANKL ratio. Toxicology and applied pharmacology. 2018 03; 343(?):62-70. doi: 10.1016/j.taap.2018.02.015. [PMID: 29477364]
  • Christine Wenz, Dagmar Faust, Berenike Linz, Christian Turmann, Teodora Nikolova, John Bertin, Peter Gough, Peter Wipf, Anna Sophia Schröder, Stefan Krautwald, Cornelia Dietrich. t-BuOOH induces ferroptosis in human and murine cell lines. Archives of toxicology. 2018 Feb; 92(2):759-775. doi: 10.1007/s00204-017-2066-y. [PMID: 28975372]
  • Nayeli Jiménez-Morales, Karina Mendoza-Ángeles, Mercedes Porras-Villalobos, Elizabeth Ibarra-Coronado, Gabriel Roldán-Roldán, Jesús Hernández-Falcón. Who is the boss? Individual recognition memory and social hierarchy formation in crayfish. Neurobiology of learning and memory. 2018 01; 147(?):79-89. doi: 10.1016/j.nlm.2017.11.017. [PMID: 29198599]
  • Chuanhua Cao, Haiying Yu, Feng Wu, Huixiong Qi, Jingbo He. Antibiotic anisomycin induces cell cycle arrest and apoptosis through inhibiting mitochondrial biogenesis in osteosarcoma. Journal of bioenergetics and biomembranes. 2017 Dec; 49(6):437-443. doi: 10.1007/s10863-017-9734-8. [PMID: 29164469]
  • Zixian Jiao, Weifeng Xu, Jisi Zheng, Pei Shen, An Qin, Shanyong Zhang, Chi Yang. Kaempferide Prevents Titanium Particle Induced Osteolysis by Suppressing JNK Activation during Osteoclast Formation. Scientific reports. 2017 11; 7(1):16665. doi: 10.1038/s41598-017-16853-w. [PMID: 29192233]
  • Chien-An Chen, Chien-Kuo Liu, Ming-Ling Hsu, Chih-Wen Chi, Chun-Chuan Ko, Jian-Syun Chen, Cheng-Ta Lai, Hen-Hong Chang, Tzung-Yan Lee, Yuen-Liang Lai, Yu-Jen Chen. Daphnoretin modulates differentiation and maturation of human dendritic cells through down-regulation of c-Jun N-terminal kinase. International immunopharmacology. 2017 Oct; 51(?):25-30. doi: 10.1016/j.intimp.2017.07.021. [PMID: 28772243]
  • Yongnan Li, Xiuxian Wu, Xinghua Jin, Jiumei Wang, Yoshikazu Togo, Toru Suzuki, Takahiko Hashimoto, Yusuke Yamada, Yukako Nakanishi, Akihiro Kanematsu, Michio Nojima, Yoshiyuki Kakehi, Shingo Yamamoto. Enhancement of death receptor 4-mediated apoptosis and cytotoxicity in renal cell carcinoma cells by anisomycin. Anti-cancer drugs. 2017 02; 28(2):180-186. doi: 10.1097/cad.0000000000000450. [PMID: 27879498]
  • Shuqing Chen, Yongqian Wang, Yubin Yang, Ting Xiang, Jiahui Liu, Houming Zhou, Xinlin Wu. Psoralen Inhibited Apoptosis of Osteoporotic Osteoblasts by Modulating IRE1-ASK1-JNK Pathway. BioMed research international. 2017; 2017(?):3524307. doi: 10.1155/2017/3524307. [PMID: 28349059]
  • Jiao Feng, Qinghui Zhang, Wenhui Mo, Liwei Wu, Sainan Li, Jingjing Li, Tong Liu, Shizan Xu, Xiaoming Fan, Chuanyong Guo. Salidroside pretreatment attenuates apoptosis and autophagy during hepatic ischemia-reperfusion injury by inhibiting the mitogen-activated protein kinase pathway in mice. Drug design, development and therapy. 2017; 11(?):1989-2006. doi: 10.2147/dddt.s136792. [PMID: 28721018]
  • David Levitan, Yaihara Fortis-Santiago, Joshua A Figueroa, Emily E Reid, Takashi Yoshida, Nicholas C Barry, Abigail Russo, Donald B Katz. Memory Retrieval Has a Dynamic Influence on the Maintenance Mechanisms That Are Sensitive to ζ-Inhibitory Peptide (ZIP). The Journal of neuroscience : the official journal of the Society for Neuroscience. 2016 10; 36(41):10654-10662. doi: 10.1523/jneurosci.1568-16.2016. [PMID: 27733615]
  • Qing Chen, Xinghui Liu, Limin Xu, Ying Wang, Suwei Wang, Qiong Li, Yongyi Huang, Te Liu. Long non-coding RNA BACE1-AS is a novel target for anisomycin-mediated suppression of ovarian cancer stem cell proliferation and invasion. Oncology reports. 2016 Apr; 35(4):1916-24. doi: 10.3892/or.2016.4571. [PMID: 26783004]
  • Tushar B Deb, Robert J Barndt, Annie H Zuo, Surojeet Sengupta, Christine M Coticchia, Michael D Johnson. PTEN-mediated ERK1/2 inhibition and paradoxical cellular proliferation following Pnck overexpression. Cell cycle (Georgetown, Tex.). 2014; 13(6):961-73. doi: 10.4161/cc.27837. [PMID: 24552815]
  • Zhenni Zhang, Jianrui Lv, Xiaoming Lei, Siyuan Li, Yong Zhang, Lihua Meng, Rongliang Xue, Zongfang Li. Baicalein reduces the invasion of glioma cells via reducing the activity of p38 signaling pathway. PloS one. 2014; 9(2):e90318. doi: 10.1371/journal.pone.0090318. [PMID: 24587321]
  • Bo Ram Seo, Kyoung-Jin Min, Shin Kim, Jong-Wook Park, Won-Kyun Park, Tae-Jin Lee, Taeg Kyu Kwon. Anisomycin treatment enhances TRAIL-mediated apoptosis in renal carcinoma cells through the down-regulation of Bcl-2, c-FLIP(L) and Mcl-1. Biochimie. 2013 Apr; 95(4):858-65. doi: 10.1016/j.biochi.2012.12.002. [PMID: 23261849]
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  • Shuang Mei, Haihua Gu, Adam Ward, Xuefeng Yang, Huailan Guo, Ka He, Zhenqi Liu, Wenhong Cao. p38 mitogen-activated protein kinase (MAPK) promotes cholesterol ester accumulation in macrophages through inhibition of macroautophagy. The Journal of biological chemistry. 2012 Apr; 287(15):11761-8. doi: 10.1074/jbc.m111.333575. [PMID: 22354961]
  • Eduard Sarró, Conxita Jacobs-Cachá, Emilio Itarte, Anna Meseguer. A pharmacologically-based array to identify targets of cyclosporine A-induced toxicity in cultured renal proximal tubule cells. Toxicology and applied pharmacology. 2012 Jan; 258(2):275-87. doi: 10.1016/j.taap.2011.11.007. [PMID: 22155090]
  • Zhengle Tang, Feiyue Xing, Di Chen, Yu Yu, Chunyan Yu, Jingfang Di, Jing Liu. In vivo toxicological evaluation of Anisomycin. Toxicology letters. 2012 Jan; 208(1):1-11. doi: 10.1016/j.toxlet.2011.10.001. [PMID: 22004851]
  • Teruo Shimmen. Involvement of protein synthesis in recovery from refractory period of electrical depolarization induced by osmotic stimulation in Chara corallina. Journal of plant research. 2011 Sep; 124(5):639-44. doi: 10.1007/s10265-010-0391-9. [PMID: 21104191]
  • Keren Weidenfeld-Baranboim, Lilach Koren, Ami Aronheim. Phosphorylation of JDP2 on threonine-148 by the c-Jun N-terminal kinase targets it for proteosomal degradation. The Biochemical journal. 2011 Jun; 436(3):661-9. doi: 10.1042/bj20101031. [PMID: 21463260]
  • N Ronkina, M B Menon, J Schwermann, J S C Arthur, H Legault, J-B Telliez, U S Kayyali, A R Nebreda, A Kotlyarov, M Gaestel. Stress induced gene expression: a direct role for MAPKAP kinases in transcriptional activation of immediate early genes. Nucleic acids research. 2011 Apr; 39(7):2503-18. doi: 10.1093/nar/gkq1178. [PMID: 21109534]
  • Jianjun Guo, Shucai Wang, Oliver Valerius, Hardy Hall, Qingning Zeng, Jian-Feng Li, David J Weston, Brian E Ellis, Jin-Gui Chen. Involvement of Arabidopsis RACK1 in protein translation and its regulation by abscisic acid. Plant physiology. 2011 Jan; 155(1):370-83. doi: 10.1104/pp.110.160663. [PMID: 21098678]
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  • Yen-Chuan Ou, Chi-Rei Yang, Chen-Li Cheng, Shue-Ling Raung, Yu-Yeh Hung, Chun-Jung Chen. Indomethacin induces apoptosis in 786-O renal cell carcinoma cells by activating mitogen-activated protein kinases and AKT. European journal of pharmacology. 2007 Jun; 563(1-3):49-60. doi: 10.1016/j.ejphar.2007.01.071. [PMID: 17341418]
  • Soon Young Shin, Joon Ho Lee, Byung Min, Young Han Lee. The translation inhibitor anisomycin induces Elk-1-mediated transcriptional activation of egr-1 through multiple mitogen-activated protein kinase pathways. Experimental & molecular medicine. 2006 Dec; 38(6):677-85. doi: 10.1038/emm.2006.80. [PMID: 17202844]
  • Sandra Ross, Teresa Chen, Violeta Yu, Yanyan Tudor, Dawei Zhang, Longbin Liu, Nuria Tamayo, Celia Dominguez, David Powers. High-content screening analysis of the p38 pathway: profiling of structurally related p38alpha kinase inhibitors using cell-based assays. Assay and drug development technologies. 2006 Aug; 4(4):397-409. doi: 10.1089/adt.2006.4.397. [PMID: 16945013]
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