Mesna (BioDeep_00000003574)

 

Secondary id: BioDeep_00000400443

natural product human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


2-Mercaptoethanesulfonic acid solution

化学式: C2H6O3S2 (141.9758366)
中文名称: 2-巯基乙磺酸, 2-巯基乙磺酸
谱图信息: 最多检出来源 Homo sapiens(blood) 1.99%

分子结构信息

SMILES: C(CS(=O)(=O)O)S
InChI: InChI=1S/C2H6O3S2/c3-7(4,5)2-1-6/h6H,1-2H2,(H,3,4,5)

描述信息

Mesna is a chemoprotectant. Chemoprotectants have been developed as a means of ameliorating the toxicity associated with cytotoxic agents by providing site-specific protection for normal tissues, without compromising antitumour efficacy. Mesna eliminates the risk of therapy-limiting urotoxic side effects of oxazaphosphorines. Mesna is widely used for the prevention of cyclophosphamide-related hemorrhagic cystitis. It has been associated with hypersensitivity-like cutaneous and systemic reactions in adult patients. Mesna offers significant uroprotection in patients receiving high dose cyclophosphamide, and is widely used in paediatric oncology practice It is, therefore, important to recognize that it may be associated with a rare but significant systemic adverse reaction. A hypersensitivity-like reaction to mesna was first reported in a young adult receiving treatment for Hodgkin disease over 20 years ago. Oral administration of mesna can facilitate outpatient ifosfamide therapy. Blood and urinary mesna concentrations are more steady and prolonged after oral delivery compared with after intravenous delivery. (PMID: 16333822, 10193684, 1485175) [HMDB]
Mesna is a chemoprotectant. Chemoprotectants have been developed as a means of ameliorating the toxicity associated with cytotoxic agents by providing site-specific protection for normal tissues, without compromising antitumour efficacy. Mesna eliminates the risk of therapy-limiting urotoxic side effects of oxazaphosphorines. Mesna is widely used for the prevention of cyclophosphamide-related hemorrhagic cystitis. It has been associated with hypersensitivity-like cutaneous and systemic reactions in adult patients. Mesna offers significant uroprotection in patients receiving high dose cyclophosphamide, and is widely used in paediatric oncology practice It is, therefore, important to recognize that it may be associated with a rare but significant systemic adverse reaction. A hypersensitivity-like reaction to mesna was first reported in a young adult receiving treatment for Hodgkin disease over 20 years ago. Oral administration of mesna can facilitate outpatient ifosfamide therapy. Blood and urinary mesna concentrations are more steady and prolonged after oral delivery compared with after intravenous delivery. (PMID: 16333822, 10193684, 1485175).
Acquisition and generation of the data is financially supported in part by CREST/JST.
D020011 - Protective Agents

同义名列表

64 个代谢物同义名

2-Mercaptoethanesulfonic acid solution; Bristol myers squibb brand OF mesna; Bristol-myers squibb brand OF mesna; 2-Mercaptoethanesulphonate, sodium; beta-Mercaptoethanesulphonic acid; Sodium 2-mercaptoethanesulphonate; beta-Mercaptoethanesulfonic acid; Sodium 2-mercaptoethanesulfonate; 2-sulfanylethane-1-sulfonic acid; b-Mercaptoethanesulphonic acid; Β-mercaptoethanesulphonic acid; 2-Mercaptoethanesulphonic acid; 2-Sulphanylethylsulphonic acid; 2-Mercaptoethylsulphonic acid; Β-mercaptoethanesulfonic acid; 2-Mercaptoethanesulfonic acid; b-Mercaptoethanesulfonic acid; beta-Mercaptoethanesulphonate; beta-Mercaptoethanesulfonate; 2-Mercaptoethylsulfonic acid; 2-Sulfanylethylsulfonic acid; ASTA medica brand OF mesna; 2-Sulphanylethylsulphonate; Β-mercaptoethanesulphonate; b-Mercaptoethanesulphonate; 2-Mercaptoethanesulphonate; 1-THIOETHANEsulphonic acid; Cell pharm brand OF mesna; 2-Mercaptoethylsulphonate; 2 Mercaptoethanesulfonate; b-Mercaptoethanesulfonate; 2-Mercaptoethanesulfonate; Β-mercaptoethanesulfonate; 1-THIOETHANEsulfonIC ACID; 2-Mercaptoethylsulfonate; 2-Sulfanylethylsulfonate; Kendrick brand OF mesna; 1-THIOETHANEsulphonate; 1-THIOETHANEsulfonate; Sanfer brand OF mesna; Mesna kendrick brand; UCB brand OF mesna; Reduced coenzyme m; Mesna sanfer brand; Mistabronco; ASTA-D 7093; ASTA D 7093; Reduced com; Coenzyme M; Coenzima m; Uromitexan; ASTAD 7093; MESNA cell; MESNA-cell; Mistabron; Coenzym m; Mucofluid; Mitexan; Mesnex; HS-CoM; Mesnum; Ziken; MESNA; CoM



数据库引用编号

31 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Kathrine J Vinknes, Thomas Olsen, Hasse Khiabani Zaré, Nasser E Bastani, Emma Stolt, Anja F Dahl, Roger D Cox, Helga Refsum, Kjetil Retterstøl, Anders Åsberg, Amany Elshorbagy. Cysteine-lowering treatment with mesna against obesity: Proof of concept and results from a human phase I, dose-finding study. Diabetes, obesity & metabolism. 2023 Jul; ?(?):. doi: 10.1111/dom.15210. [PMID: 37435697]
  • Abigail B Donkor, Carl W White, Heidi J Nick, Brian A Logue. Analysis of sodium 2-mercaptoethane sulfonate in rat plasma using high performance liquid chromatography tandem-mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2022 Jan; 1189(?):123088. doi: 10.1016/j.jchromb.2021.123088. [PMID: 34974317]
  • Jonathan Fishman, Edward W Fisher. 'Chemically assisted dissection' in cholesteatoma surgery, Eustachian tube balloon dilatation post-irradiation, and coronavirus disease 2019 and the undergraduate curriculum. The Journal of laryngology and otology. 2021 08; 135(8):659. doi: 10.1017/s0022215121001870. [PMID: 34342557]
  • Hanan H Hagar, Sarah A Almubrik, Nada M Attia, Sarah N Aljasser. Mesna Alleviates Cerulein-Induced Acute Pancreatitis by Inhibiting the Inflammatory Response and Oxidative Stress in Experimental Rats. Digestive diseases and sciences. 2020 12; 65(12):3583-3591. doi: 10.1007/s10620-020-06072-1. [PMID: 32088797]
  • Sarita Rani Jaiswal, Paras Singhal, Atul Thatai, Gitali Bhagwati, Hema Malini Aiyer, Aditi Chakrabarti, Suparno Chakrabarti. Impact of extended infusional mesna prophylaxis on the incidence of BK viruria and hemorrhagic cystitis following post-transplantation cyclophosphamide and CTLA4Ig-based haploidentical transplantation. Annals of hematology. 2020 Apr; 99(4):839-845. doi: 10.1007/s00277-020-03930-w. [PMID: 32025839]
  • Nathan A Hirshman, Francis M Hughes, Huixia Jin, William T Harrison, Simon W White, Isabelle Doan, Shelby N Harper, Patrick D Leidig, J Todd Purves. Cyclophosphamide-induced cystitis results in NLRP3-mediated inflammation in the hippocampus and symptoms of depression in rats. American journal of physiology. Renal physiology. 2020 02; 318(2):F354-F362. doi: 10.1152/ajprenal.00408.2019. [PMID: 31869244]
  • Asmahan Abu-Arish, Elvis Pandžić, Dusik Kim, Hsin Wei Tseng, Paul W Wiseman, John W Hanrahan. Agonists that stimulate secretion promote the recruitment of CFTR into membrane lipid microdomains. The Journal of general physiology. 2019 06; 151(6):834-849. doi: 10.1085/jgp.201812143. [PMID: 31048413]
  • Negin Mahmoudi, Sahar Eftekharzadeh, Marzieh Golmohammadi, Reza Khorramirouz, Javad Hashemi, Zeinab Kashani, Maryam Alijani, Amir Ali Hamidieh, Abdol-Mohammad Kajbafzadeh. Alleviation of Cyclophosphamide-induced Hemorrhagic Cystitis by Dietary Pomegranate: A Comparative Experimental Study With Mesna. Journal of pediatric hematology/oncology. 2018 11; 40(8):609-615. doi: 10.1097/mph.0000000000001203. [PMID: 29734214]
  • Yoshimasa Saito, Tadashi Kumamoto, Miki Shiraiwa, Tomoko Sonoda, Ayumu Arakawa, Hironobu Hashimoto, Ikumi Tamai, Chitose Ogawa, Hiroyuki Terakado. Cyclophosphamide-induced hemorrhagic cystitis in young patients with solid tumors: A single institution study. Asia-Pacific journal of clinical oncology. 2018 Oct; 14(5):e460-e464. doi: 10.1111/ajco.13048. [PMID: 29989294]
  • C J Henry, B K Flesner, S A Bechtel, J N Bryan, D J Tate, K A Selting, J C Lattimer, M E Bryan, L Grubb, F Hausheer. Clinical Evaluation of Tavocept to Decrease Diuresis Time and Volume in Dogs with Bladder Cancer Receiving Cisplatin. Journal of veterinary internal medicine. 2018 Jan; 32(1):370-376. doi: 10.1111/jvim.14848. [PMID: 29080252]
  • Roohi Jeelani, Seyedehameneh Jahanbakhsh, Hamid-Reza Kohan-Ghadr, Mili Thakur, Sana Khan, Sarah R Aldhaheri, Zhe Yang, Peter Andreana, Robert Morris, Husam M Abu-Soud. Mesna (2-mercaptoethane sodium sulfonate) functions as a regulator of myeloperoxidase. Free radical biology & medicine. 2017 09; 110(?):54-62. doi: 10.1016/j.freeradbiomed.2017.05.019. [PMID: 28552694]
  • Benjamin J Tarrant, Caitlin Le Maitre, Lorena Romero, Ranjana Steward, Brenda M Button, Bruce R Thompson, Anne E Holland. Mucoactive agents for chronic, non-cystic fibrosis lung disease: A systematic review and meta-analysis. Respirology (Carlton, Vic.). 2017 08; 22(6):1084-1092. doi: 10.1111/resp.13047. [PMID: 28397992]
  • Lucélia Borgo. Evaluation of buffers toxicity in tobacco cells: Homopiperazine-1,4-bis (2-ethanesulfonic acid) is a suitable buffer for plant cells studies at low pH. Plant physiology and biochemistry : PPB. 2017 Jun; 115(?):119-125. doi: 10.1016/j.plaphy.2017.03.012. [PMID: 28364708]
  • Yoshimasa Saito, Tadashi Kumamoto, Yoshinori Makino, Ikumi Tamai, Chitose Ogawa, Hiroyuki Terakado. A retrospective study of treatment and prophylaxis of ifosfamide-induced hemorrhagic cystitis in pediatric and adolescent and young adult (AYA) patients with solid tumors. Japanese journal of clinical oncology. 2016 Sep; 46(9):856-61. doi: 10.1093/jjco/hyw093. [PMID: 27380806]
  • Paulina Furmaniak, Paweł Kubalczyk, Justyna Stachniuk, Rafał Głowacki. Novel MEKC method for determination of sodium 2-mercaptoethanesulfonate in human plasma with in-capillary derivatization and UV detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Aug; 1027(?):88-95. doi: 10.1016/j.jchromb.2016.05.032. [PMID: 27266402]
  • Keyvan Amirshahrokhi, Ali-Reza Khalili. Gastroprotective effect of 2-mercaptoethane sulfonate against acute gastric mucosal damage induced by ethanol. International immunopharmacology. 2016 May; 34(?):183-188. doi: 10.1016/j.intimp.2016.03.006. [PMID: 26967742]
  • Q Jiang, H Huang, Q Liu, J Sun, H Zhou, Z Fan, Y Zhang, F Huang, Y Chai, D Xu, Y Lu, Q Wei, G Yu, X Li, M Dai, N Xu, D Zhou, H Zhao, K Shen, Q Mai, Y Zhou, F Meng. Continuous IV infusion of MESNA can prevent hemorrhagic cystitis in HSCT and retain MESNA concentration in urine. Bone marrow transplantation. 2015 Nov; 50(11):1490-2. doi: 10.1038/bmt.2015.197. [PMID: 26367223]
  • Myrtle Davis, Deborah I Bunin, Steven J Samuelsson, Kenneth P Altera, Robert J Kinders, Scott M Lawrence, Jiuping Ji, Matthew M Ames, Sarah A Buhrow, Chad Walden, Joel M Reid, Linda L Rausch, Toufan Parman. Characterization of Batracylin-induced Renal and Bladder Toxicity in Rats. Toxicologic pathology. 2015 Jun; 43(4):519-29. doi: 10.1177/0192623314548766. [PMID: 25274659]
  • Murray J Cutler, Thomas J Velenosi, Ankur Bodalia, Andrew A House, Bradley L Urquhart, David J Freeman. Enzymatic and non-enzymatic mechanisms of dimesna metabolism. Amino acids. 2015 Mar; 47(3):511-23. doi: 10.1007/s00726-014-1882-0. [PMID: 25488427]
  • John Hayslip, Emily V Dressler, Heidi Weiss, Tammy J Taylor, Mara Chambers, Teresa Noel, Sumitra Miriyala, Jeriel T R Keeney, Xiaojia Ren, Rukhsana Sultana, Mary Vore, D Allan Butterfield, Daret St Clair, Jeffrey A Moscow. Plasma TNF-α and Soluble TNF Receptor Levels after Doxorubicin with or without Co-Administration of Mesna-A Randomized, Cross-Over Clinical Study. PloS one. 2015; 10(4):e0124988. doi: 10.1371/journal.pone.0124988. [PMID: 25909710]
  • Tatoba R Waghmode, Md Mozammel Haque, Sang Yoon Kim, Pil Joo Kim. Effective Suppression of Methane Emission by 2-Bromoethanesulfonate during Rice Cultivation. PloS one. 2015; 10(11):e0142569. doi: 10.1371/journal.pone.0142569. [PMID: 26562416]
  • Risikat Ajibola Adigun, Bice Martincigh, Vincent O Nyamori, Bernard Omondi, Collen Masimirembwa, Reuben H Simoyi. Kinetics and mechanistic investigation into the possible activation of imidazolium trans-[tetrachloridodimethylsulfoxideimidazoleruthenate(III)], NAMI-A, by 2-mercaptoethane sulfonate. Dalton transactions (Cambridge, England : 2003). 2014 Sep; 43(34):12943-51. doi: 10.1039/c4dt01643b. [PMID: 25026023]
  • Danila Di Giuseppe, Raffaella Priora, Lucia Coppo, Monica Ulivelli, Sabina Bartalini, Domenico Summa, Antonios Margaritis, Simona Frosali, Paolo Di Simplicio. The control of hyperhomocysteinemia through thiol exchange mechanisms by mesna. Amino acids. 2014 Feb; 46(2):429-39. doi: 10.1007/s00726-013-1636-4. [PMID: 24337902]
  • Teigo Asai, Dan Luo, Kouwa Yamashita, Yoshiteru Oshima. Structures and biomimetic synthesis of novel α-pyrone polyketides of an endophytic Penicillium sp. in Catharanthus roseus. Organic letters. 2013 Mar; 15(5):1020-3. doi: 10.1021/ol303506t. [PMID: 23405967]
  • Lisa Truong, Susan C Tilton, Tatiana Zaikova, Erik Richman, Katrina M Waters, James E Hutchison, Robert L Tanguay. Surface functionalities of gold nanoparticles impact embryonic gene expression responses. Nanotoxicology. 2013 Mar; 7(2):192-201. doi: 10.3109/17435390.2011.648225. [PMID: 22263968]
  • Erdal Resit Yilmaz, Hayri Kertmen, Bora Gürer, Mehmet Ali Kanat, Ata Türker Arikok, Berrin Imge Ergüder, Askin Esen Hasturk, Julide Ergil, Zeki Sekerci. The protective effect of 2-mercaptoethane sulfonate (MESNA) against traumatic brain injury in rats. Acta neurochirurgica. 2013 Jan; 155(1):141-9; discussion 149. doi: 10.1007/s00701-012-1501-3. [PMID: 23053276]
  • Dana Baram-Pinto, Sourabh Shukla, Michal Richman, Aharon Gedanken, Shai Rahimipour, Ronit Sarid. Surface-modified protein nanospheres as potential antiviral agents. Chemical communications (Cambridge, England). 2012 Aug; 48(67):8359-61. doi: 10.1039/c2cc33448h. [PMID: 22798998]
  • Anna Dietrich-Muszalska, Joanna Malinowska, Beata Olas, Rafal Głowacki, Edward Bald, Barbara Wachowicz, Jolanta Rabe-Jabłońska. The oxidative stress may be induced by the elevated homocysteine in schizophrenic patients. Neurochemical research. 2012 May; 37(5):1057-62. doi: 10.1007/s11064-012-0707-3. [PMID: 22270909]
  • M J Cutler, B L Urquhart, T J Velenosi, H E Meyer Zu Schwabedissen, G K Dresser, B F Leake, R G Tirona, R B Kim, D J Freeman. In vitro and in vivo assessment of renal drug transporters in the disposition of mesna and dimesna. Journal of clinical pharmacology. 2012 Apr; 52(4):530-42. doi: 10.1177/0091270011400414. [PMID: 21505084]
  • Zdeněk Svagera, Dagmar Hanzlíková, Petr Simek, Petr Hušek. Study of disulfide reduction and alkyl chloroformate derivatization of plasma sulfur amino acids using gas chromatography-mass spectrometry. Analytical and bioanalytical chemistry. 2012 Mar; 402(9):2953-63. doi: 10.1007/s00216-012-5727-y. [PMID: 22349320]
  • Francisco Yuri Bulcão Macedo, Lívia Talita Cajaseiras Mourão, Helano Carioca Freitas, Roberto C P Lima, Deysi Viviana Tenazoa Wong, Reinaldo Barreto Oriá, Mariana L Vale, Gerly Anne Casto Brito, Fernando Q Cunha, Ronaldo A Ribeiro. Interleukin-4 modulates the inflammatory response in ifosfamide-induced hemorrhagic cystitis. Inflammation. 2012 Feb; 35(1):297-307. doi: 10.1007/s10753-011-9319-3. [PMID: 21468627]
  • William Jacot, Jean-Louis Pujol, Mohammad Chakra, Olivier Molinier, Marie-Cécile Bozonnat, Radj Gervais, Xavier Quantin. Epirubicin and ifosfamide in relapsed or refractory small cell lung cancer patients. Lung cancer (Amsterdam, Netherlands). 2012 Feb; 75(2):213-6. doi: 10.1016/j.lungcan.2011.07.012. [PMID: 21831476]
  • Mahdi Aghili, Elham Rafiei, Mohamad Mojahed, Mahkameh Zare. Renal primitive neuroectodermal tumor: does age at diagnosis impact outcomes?. Rare tumors. 2012 Jan; 4(1):e15. doi: 10.4081/rt.2012.e15. [PMID: 22532913]
  • Aparna Gangopadhyay, Partha Nath, Mofizur Rahman Khan, Jaydip Biswas. Bladder Carcinoma after ABVD Chemotherapy for Hodgkin's Lymphoma: A Case Report. Case reports in oncology. 2012 Jan; 5(1):148-53. doi: 10.1159/000338040. [PMID: 22666204]
  • Yousra Akasbi, Samia Arifi, Karim Lahlaidi, Tarik Namad, Nawfel Mellas, Mohammed Jamal El Fassi, My Hassan Farih, Afaf Amarti, Omar El Mesbahi. Renal metastases of a femur osteosarcoma: a case report and a review of the literature. Case reports in urology. 2012; 2012(?):259193. doi: 10.1155/2012/259193. [PMID: 22606633]
  • Franz-Georg Hanisch, Carol L Kinlough, Simon Staubach, Rebecca P Hughey. MUC1 membrane trafficking: protocols for assessing biosynthetic delivery, endocytosis, recycling, and release through exosomes. Methods in molecular biology (Clifton, N.J.). 2012; 842(?):123-40. doi: 10.1007/978-1-61779-513-8_7. [PMID: 22259133]
  • Joseph D Dukes, Paul Whitley, Andrew D Chalmers. The PIKfyve inhibitor YM201636 blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cells. PloS one. 2012; 7(3):e28659. doi: 10.1371/journal.pone.0028659. [PMID: 22396724]
  • Jee Young Kim, Kee Duk Park, David P Richman. Treatment of myasthenia gravis based on its immunopathogenesis. Journal of clinical neurology (Seoul, Korea). 2011 Dec; 7(4):173-83. doi: 10.3988/jcn.2011.7.4.173. [PMID: 22259613]
  • Deepak B Thimiri Govinda Raj, Bart Ghesquière, Arun Kumar Tharkeshwar, Katrijn Coen, Rita Derua, Dieter Vanderschaeghe, Evelien Rysman, Murali Bagadi, Pieter Baatsen, Bart De Strooper, Etienne Waelkens, Gustaaf Borghs, Nico Callewaert, Johan Swinnen, Kris Gevaert, Wim Annaert. A novel strategy for the comprehensive analysis of the biomolecular composition of isolated plasma membranes. Molecular systems biology. 2011 Oct; 7(?):541. doi: 10.1038/msb.2011.74. [PMID: 22027552]
  • Yue Han, Li Zhu, Aining Sun, Xiaoxu Lu, Luping Hu, Lili Zhou, Yongya Ren, Xiaohui Hu, Xiaojin Wu, Zhaoyue Wang, Changgeng Ruan, Depei Wu. Alterations of hemostatic parameters in the early development of allogeneic hematopoietic stem cell transplantation-related complications. Annals of hematology. 2011 Oct; 90(10):1201-8. doi: 10.1007/s00277-011-1273-5. [PMID: 21674145]
  • Yun Jeung Kim, Hee Seok Moon, Eaum Seok Lee, Jae Kyu Sung, Hyun Yong Jeong, Ji Yeon Kim, Dae Young Kang. Recurrent renal leiomyosarcoma mimicking a colonic submucosal tumor: a case report. Journal of the Korean Society of Coloproctology. 2011 Oct; 27(5):270-4. doi: 10.3393/jksc.2011.27.5.270. [PMID: 22102979]
  • Vinícios T Boeira, Carlos E Leite, André A Santos, Maria I Edelweiss, João B Calixto, Maria M Campos, Fernanda B Morrone. Effects of the hydroalcoholic extract of Phyllanthus niruri and its isolated compounds on cyclophosphamide-induced hemorrhagic cystitis in mouse. Naunyn-Schmiedeberg's archives of pharmacology. 2011 Sep; 384(3):265-75. doi: 10.1007/s00210-011-0668-0. [PMID: 21789632]
  • F H Hausheer, D Ding, D Shanmugarajah, B D Leverett, Q Huang, X Chen, H Kochat, P Y Ayala, P N Petluru, A R Parker. Accumulation of BNP7787 in human renal proximal tubule cells. Journal of pharmaceutical sciences. 2011 Sep; 100(9):3977-84. doi: 10.1002/jps.22510. [PMID: 21344411]
  • S K Annavarajula, K V D Murty, A Prayaga, U Das, M Desai, C A Narain. The outcome of proliferative lupus nephritis with pulse cyclophosphamide therapy. Indian journal of nephrology. 2011 Jul; 21(3):160-5. doi: 10.4103/0971-4065.83933. [PMID: 21886974]
  • Petros Ypsilantis, Maria Lambropoulou, Constantinos Anagnostopoulos, Ioannis Tentes, Christina Tsigalou, Michail Pitiakoudis, Alexandros Kortsaris, Nikolaos Papadopoulos, Constantinos Simopoulos. Mesna preserves hepatocyte regenerating capacity following liver radiofrequency ablation under Pringle maneuver. The Journal of surgical research. 2011 Jul; 169(1):44-50. doi: 10.1016/j.jss.2009.10.001. [PMID: 20080247]
  • Christopher D Aluise, Sumitra Miriyala, Teresa Noel, Rukhsana Sultana, Paiboon Jungsuwadee, Tamara J Taylor, Jian Cai, William M Pierce, Mary Vore, Jeffrey A Moscow, Daret K St Clair, D Allan Butterfield. 2-Mercaptoethane sulfonate prevents doxorubicin-induced plasma protein oxidation and TNF-α release: implications for the reactive oxygen species-mediated mechanisms of chemobrain. Free radical biology & medicine. 2011 Jun; 50(11):1630-8. doi: 10.1016/j.freeradbiomed.2011.03.009. [PMID: 21421044]
  • Robyn M Carey, Jan K Blusztajn, Barbara E Slack. Surface expression and limited proteolysis of ADAM10 are increased by a dominant negative inhibitor of dynamin. BMC cell biology. 2011 May; 12(?):20. doi: 10.1186/1471-2121-12-20. [PMID: 21586144]
  • Blythe E Janowiak, Laura D Jennings-Antipov, R John Collier. Cys-Cys cross-linking shows contact between the N-terminus of lethal factor and Phe427 of the anthrax toxin pore. Biochemistry. 2011 May; 50(17):3512-6. doi: 10.1021/bi1017446. [PMID: 21425869]
  • Joanna Stefanowicz, Mateusz Kosiak, Grzegorz Romanowicz, Radosław Owczuk, Elżbieta Adamkiewicz-Drożyńska, Anna Balcerska. Glomerular filtration rate and prevalence of chronic kidney disease in Wilms' tumour survivors. Pediatric nephrology (Berlin, Germany). 2011 May; 26(5):759-66. doi: 10.1007/s00467-011-1759-3. [PMID: 21279390]
  • Evgeny A Zemskov, Irina Mikhailenko, Ru-Ching Hsia, Liubov Zaritskaya, Alexey M Belkin. Unconventional secretion of tissue transglutaminase involves phospholipid-dependent delivery into recycling endosomes. PloS one. 2011 Apr; 6(4):e19414. doi: 10.1371/journal.pone.0019414. [PMID: 21556374]
  • Francisco Y B Macedo, Lívia T C Mourão, Raimundo C Palheta, Davi M Jucá, Roberto C P Lima, José de Sá C Neto, Pedro J C Magalhães, Armênio A Santos, Marcellus H L P Souza, Gerly A C Brito, Ronaldo A Ribeiro. Cyclooxygenase-2 contributes to functional changes seen on experimental hemorrhagic cystitis induced by ifosfamide in rat urinary bladder. Cancer chemotherapy and pharmacology. 2011 Apr; 67(4):935-43. doi: 10.1007/s00280-010-1392-z. [PMID: 20602232]
  • U Ludwig, M K Riedel, M Backes, A Imhof, R Muche, F Keller. MESNA (sodium 2-mercaptoethanesulfonate) for prevention of contrast medium-induced nephrotoxicity - controlled trial. Clinical nephrology. 2011 Apr; 75(4):302-8. doi: 10.5414/cn106651. [PMID: 21426884]
  • Nancy Zaarour, Nadia Defontaine, Sylvie Demaretz, Anie Azroyan, Lydie Cheval, Kamel Laghmani. Secretory carrier membrane protein 2 regulates exocytic insertion of NKCC2 into the cell membrane. The Journal of biological chemistry. 2011 Mar; 286(11):9489-502. doi: 10.1074/jbc.m110.166546. [PMID: 21205824]
  • Gilho Lee. Uroplakins in the lower urinary tract. International neurourology journal. 2011 Mar; 15(1):4-12. doi: 10.5213/inj.2011.15.1.4. [PMID: 21468280]
  • F H Hausheer, A R Parker, P N Petluru, K W Jair, S Chen, Q Huang, X Chen, P Y Ayala, D Shanmugarajah, H Kochat. Mechanistic study of BNP7787-mediated cisplatin nephroprotection: modulation of human aminopeptidase N. Cancer chemotherapy and pharmacology. 2011 Feb; 67(2):381-91. doi: 10.1007/s00280-010-1333-x. [PMID: 20440617]
  • Kurt Van der Speeten, O Anthony Stuart, Haile Mahteme, Paul H Sugarbaker. Pharmacokinetic study of perioperative intravenous Ifosfamide. International journal of surgical oncology. 2011; 2011(?):185092. doi: 10.1155/2011/185092. [PMID: 22312496]
  • M Marin-Kuan, V Ehrlich, T Delatour, C Cavin, B Schilter. Evidence for a role of oxidative stress in the carcinogenicity of ochratoxin a. Journal of toxicology. 2011; 2011(?):645361. doi: 10.1155/2011/645361. [PMID: 21776264]
  • Mark N Adams, Melinda E Christensen, Yaowu He, Nigel J Waterhouse, John D Hooper. The role of palmitoylation in signalling, cellular trafficking and plasma membrane localization of protease-activated receptor-2. PloS one. 2011; 6(11):e28018. doi: 10.1371/journal.pone.0028018. [PMID: 22140500]
  • Christian Niehage, Charlotte Steenblock, Theresia Pursche, Martin Bornhäuser, Denis Corbeil, Bernard Hoflack. The cell surface proteome of human mesenchymal stromal cells. PloS one. 2011; 6(5):e20399. doi: 10.1371/journal.pone.0020399. [PMID: 21637820]
  • Mehmet Gulum, Ercan Yeni, Murat Savas, Ilyas Ozardali, Ismail Ozdemir, Dilek Mil, Adem Altunkol, Halil Ciftci. Primary renal synovial sarcoma. Case reports in urology. 2011; 2011(?):810184. doi: 10.1155/2011/810184. [PMID: 22606625]
  • Sarah E Hook, André-Denis G Wright, Brian W McBride. Methanogens: methane producers of the rumen and mitigation strategies. Archaea (Vancouver, B.C.). 2010 Dec; 2010(?):945785. doi: 10.1155/2010/945785. [PMID: 21253540]
  • Young Il Kim, Ju Young Yoon, Jun Eul Hwang, Hyun Jeong Shim, Woo Kyun Bae, Sang Hee Cho, Ik-Joo Chung. Reversible proximal renal tubular dysfunction after one-time Ifosfamide exposure. Cancer research and treatment. 2010 Dec; 42(4):244-6. doi: 10.4143/crt.2010.42.4.244. [PMID: 21253328]
  • Pier Carlo Braga, Monica Dal Sasso, Maria Culici, Alessandra Spallino, Laura Marabini, Tiziana Bianchi, Giuseppe Nappi. Effects of sulphurous water on human neutrophil elastase release. Therapeutic advances in respiratory disease. 2010 Dec; 4(6):333-40. doi: 10.1177/1753465810376783. [PMID: 20650977]
  • Osama M Sarhan, Mahmoud El-Baz, Mohamed M Sarhan, Ahmed M Ghali, Mohamed A Ghoneim. Bilateral Wilms' tumors: single-center experience with 22 cases and literature review. Urology. 2010 Oct; 76(4):946-51. doi: 10.1016/j.urology.2010.03.055. [PMID: 20708784]
  • Andrzej Kudelski. Raman characterization of monolayers formed from mixtures of sodium 2-mercaptoethanesulfonate and various aromatic mercapto-derivative bases. The journal of physical chemistry. B. 2010 Apr; 114(15):5180-9. doi: 10.1021/jp100196x. [PMID: 20353251]
  • Frederick H Hausheer, Dakshine Shanmugarajah, Betsy D Leverett, Xinghai Chen, Quili Huang, Harry Kochat, Pavankumar N Petluru, Aulma R Parker. Mechanistic study of BNP7787-mediated cisplatin nephroprotection: modulation of gamma-glutamyl transpeptidase. Cancer chemotherapy and pharmacology. 2010 Apr; 65(5):941-51. doi: 10.1007/s00280-009-1101-y. [PMID: 19714332]
  • Sascha Pust, Anne Berit Dyve, Maria L Torgersen, Bo van Deurs, Kirsten Sandvig. Interplay between toxin transport and flotillin localization. PloS one. 2010 Jan; 5(1):e8844. doi: 10.1371/journal.pone.0008844. [PMID: 20107503]
  • Toru Sugihara, Tetsuya Fujimura, Haruki Kume, Yukio Homma. Successful treatment of metastatic malignant fibrous histiocytoma of the kidney. Urologia internationalis. 2010; 85(1):118-20. doi: 10.1159/000315874. [PMID: 20516674]
  • Yasuhiro Yamada, Yoshiaki Ikuta, Kisato Nosaka, Nobutomo Miyanari, Naoko Hayashi, Hiroaki Mitsuya, Hideo Baba. Successful treatment of Cisplatin overdose with plasma exchange. Case reports in medicine. 2010; 2010(?):802312. doi: 10.1155/2010/802312. [PMID: 20300587]
  • Zhang Xiping, Weng Ke, Yu Yaping, Zhao Hongchan, Cheng Qihui. Protective effect and mechanisms of radix astragali injection on the intestinal mucosa of rats with obstructive jaundice. Mediators of inflammation. 2010; 2010(?):757191. doi: 10.1155/2010/757191. [PMID: 20300591]
  • Krzysztof Kuśmierek, Grazyna Chwatko, Rafał Głowacki, Edward Bald. Determination of endogenous thiols and thiol drugs in urine by HPLC with ultraviolet detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2009 Oct; 877(28):3300-8. doi: 10.1016/j.jchromb.2009.03.038. [PMID: 19386557]
  • Petros Ypsilantis, Maria Lambropoulou, Ioannis Tentes, Konstantinos Anagnostopoulos, Christina Tsigalou, Nikolaos Papadopoulos, Alexandros Kortsaris, Constantinos Simopoulos. Impaired liver regeneration following partial hepatectomy using the Pringle maneuver: Protective effect of mesna. Journal of gastroenterology and hepatology. 2009 Apr; 24(4):623-32. doi: 10.1111/j.1440-1746.2008.05641.x. [PMID: 19032449]
  • Dakshine Shanmugarajah, Daoyuan Ding, Quili Huang, Xinghai Chen, Harry Kochat, Pavankumar N Petluru, Philippe Y Ayala, Aulma R Parker, Frederick H Hausheer. Analysis of BNP7787 thiol-disulfide exchange reactions in phosphate buffer and human plasma using microscale electrochemical high performance liquid chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2009 Apr; 877(10):857-66. doi: 10.1016/j.jchromb.2009.02.056. [PMID: 19278906]
  • Corine Ekhart, Sjoerd Rodenhuis, Jos H Beijnen, Alwin D R Huitema. Pharmacokinetics of cyclophosphamide and thiotepa in a conventional fractionated high-dose regimen compared with a novel simplified unfractionated regimen. Therapeutic drug monitoring. 2009 Feb; 31(1):95-103. doi: 10.1097/ftd.0b013e318194e484. [PMID: 19155964]
  • Zaki S Badawy, Abdul-Kader Souid. Inhibition of human sperm respiration by 4-hydroperoxycyclophosphamide and protection by mesna and WR-1065. Fertility and sterility. 2009 Jan; 91(1):173-8. doi: 10.1016/j.fertnstert.2007.11.008. [PMID: 18206143]
  • Murray J Cutler, Bradley L Urquhart, David J Freeman, J David Spence, Andrew A House. Mesna for the treatment of hyperhomocysteinemia in hemodialysis patients. Blood purification. 2009; 27(3):306-10. doi: 10.1159/000207197. [PMID: 19270449]
  • Suresh Kumar Kailasa, Kamatam Kiran, Hui-Fen Wu. Comparison of ZnS semiconductor nanoparticles capped with various functional groups as the matrix and affinity probes for rapid analysis of cyclodextrins and proteins in surface-assisted laser desorption/ionization time-of-flight mass spectrometry. Analytical chemistry. 2008 Dec; 80(24):9681-8. doi: 10.1021/ac8015664. [PMID: 18991387]
  • Benoit You, Brigitte Tranchand, Pascal Girard, Claire Falandry, Benjamin Ribba, Sylvie Chabaud, Pierre-Jean Souquet, Isabelle Court-Fortune, Véronique Trillet-Lenoir, Cécile Fournel, Michel Tod, Gilles Freyer. Etoposide pharmacokinetics and survival in patients with small cell lung cancer: a multicentre study. Lung cancer (Amsterdam, Netherlands). 2008 Nov; 62(2):261-72. doi: 10.1016/j.lungcan.2008.03.008. [PMID: 18442869]
  • Bradley L Urquhart, David J Freeman, Murray J Cutler, Rahul Mainra, J David Spence, Andrew A House. Mesna for treatment of hyperhomocysteinemia in hemodialysis patients: a placebo-controlled, double-blind, randomized trial. Clinical journal of the American Society of Nephrology : CJASN. 2008 Jul; 3(4):1041-7. doi: 10.2215/cjn.04771107. [PMID: 18337551]
  • Peter G Mantle, Judit M Nagy. Binding of ochratoxin A to a urinary globulin: a new concept to account for gender difference in rat nephrocarcinogenic responses. International journal of molecular sciences. 2008 May; 9(5):719-35. doi: 10.3390/ijms9050719. [PMID: 19325780]
  • John Yeh, Beom Su Kim, Jennifer Peresie. Protection against cisplatin-induced ovarian damage by the antioxidant sodium 2-mercaptoethanesulfonate (mesna) in female rats. American journal of obstetrics and gynecology. 2008 Apr; 198(4):463.e1-6; discussion 463.e6. doi: 10.1016/j.ajog.2007.12.027. [PMID: 18395042]
  • Zeinab Yaseen, Christian Michoudet, Gabriel Baverel, Laurence Dubourg. In vivo mesna and amifostine do not prevent chloroacetaldehyde nephrotoxicity in vitro. Pediatric nephrology (Berlin, Germany). 2008 Apr; 23(4):611-8. doi: 10.1007/s00467-007-0689-6. [PMID: 18204866]
  • Jacob Collen, Mark Carmichael, Tanya Wroblewski. Metastatic malignant teratoma arising from mediastinal nonseminomatous germ cell tumor: a case report. Military medicine. 2008 Apr; 173(4):406-9. doi: 10.7205/milmed.173.4.406. [PMID: 18472634]
  • Molouk Hadjibabaie, Kamran Alimoghaddam, Ahmad Reza Shamshiri, Masoud Iravani, Babak Bahar, Asadollah Mousavi, Mohammad Jahani, Ali Khodabandeh, Yasha Anvari, Kheirollah Gholami, Ardeshir Ghavamzadeh. Continuous bladder irrigation prevents hemorrhagic cystitis after allogeneic hematopoietic cell transplantation. Urologic oncology. 2008 Jan; 26(1):43-6. doi: 10.1016/j.urolonc.2006.12.015. [PMID: 18190829]
  • Serdar Sadir, Salih Deveci, Ahmet Korkmaz, Sukru Oter. Alpha-tocopherol, beta-carotene and melatonin administration protects cyclophosphamide-induced oxidative damage to bladder tissue in rats. Cell biochemistry and function. 2007 Sep; 25(5):521-6. doi: 10.1002/cbf.1347. [PMID: 16850520]
  • A Korkmaz, T Topal, S Oter. Pathophysiological aspects of cyclophosphamide and ifosfamide induced hemorrhagic cystitis; implication of reactive oxygen and nitrogen species as well as PARP activation. Cell biology and toxicology. 2007 Sep; 23(5):303-12. doi: 10.1007/s10565-006-0078-0. [PMID: 17225077]
  • Bradley L Urquhart, David J Freeman, J David Spence, Andrew A House. Mesna as a nonvitamin intervention to lower plasma total homocysteine concentration: implications for assessment of the homocysteine theory of atherosclerosis. Journal of clinical pharmacology. 2007 Aug; 47(8):991-7. doi: 10.1177/0091270007303767. [PMID: 17615252]
  • Paul L Wood, M Amin Khan, Joseph R Moskal. Cellular thiol pools are responsible for sequestration of cytotoxic reactive aldehydes: central role of free cysteine and cysteamine. Brain research. 2007 Jul; 1158(?):158-63. doi: 10.1016/j.brainres.2007.05.007. [PMID: 17555724]
  • Gerald Schwerdt, Antje Kirchhoff, Ruth Freudinger, Brigitte Wollny, Andreas Benesic, Michael Gekle. Mesna or cysteine prevents chloroacetaldehyde-induced cell death of human proximal tubule cells. Pediatric nephrology (Berlin, Germany). 2007 Jun; 22(6):798-803. doi: 10.1007/s00467-006-0414-x. [PMID: 17273862]
  • James Springate, Mary Taub. Ifosfamide toxicity in cultured proximal renal tubule cells. Pediatric nephrology (Berlin, Germany). 2007 Mar; 22(3):358-65. doi: 10.1007/s00467-006-0328-7. [PMID: 17072651]
  • Yasushi Yoshida, Katsuhiko Inoue, Tomofumi Ohsako, Nobuhide Nagamoto, Eiji Tanaka, Shu Tsuruzoe. [Weekly paclitaxel therapy is curative for patients with retroperitoneal liposarcoma]. Gan to kagaku ryoho. Cancer & chemotherapy. 2007 Mar; 34(3):465-7. doi: NULL. [PMID: 17353645]
  • Bradley L Urquhart, David J Freeman, J David Spence, Andrew A House. The effect of mesna on plasma total homocysteine concentration in hemodialysis patients. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2007 Jan; 49(1):109-17. doi: 10.1053/j.ajkd.2006.10.002. [PMID: 17185151]
  • L Patzer, N Hernando, U Ziegler, B Beck-Schimmer, J Biber, H Murer. Ifosfamide metabolites CAA, 4-OH-Ifo and Ifo-mustard reduce apical phosphate transport by changing NaPi-IIa in OK cells. Kidney international. 2006 Nov; 70(10):1725-34. doi: 10.1038/sj.ki.5001803. [PMID: 17003823]
  • Bradley L Urquhart, Andrew A House, Murray J Cutler, J David Spence, David J Freeman. Thiol exchange: an in vitro assay that predicts the efficacy of novel homocysteine lowering therapies. Journal of pharmaceutical sciences. 2006 Aug; 95(8):1742-50. doi: 10.1002/jps.20680. [PMID: 16795014]
  • J R Tysome, A Sandison, P M Clarke. Myxoid liposarcoma metastatic to the thyroid gland: a case report and literature review. The Journal of laryngology and otology. 2006 Jun; 120(6):511-3. doi: 10.1017/s0022215106000867. [PMID: 16563196]
  • Göksel Sener, Levent Kabasakal, Ozer Sehirli, Feriha Ercan, Nursal Gedik. 2-Mercaptoethane sulfonate (MESNA) protects against biliary obstruction-induced oxidative damage in rats. Hepatology research : the official journal of the Japan Society of Hepatology. 2006 Jun; 35(2):140-6. doi: 10.1016/j.hepres.2006.02.009. [PMID: 16584914]
  • Virginie Faucet-Marquis, Frédéric Pont, Frederik C Størmer, Toufik Rizk, Marcel Castegnaro, Annie Pfohl-Leszkowicz. Evidence of a new dechlorinated ochratoxin A derivative formed in opossum kidney cell cultures after pretreatment by modulators of glutathione pathways: correlation with DNA-adduct formation. Molecular nutrition & food research. 2006 May; 50(6):530-42. doi: 10.1002/mnfr.200500219. [PMID: 16671059]
  • Michael Darmon, Magali Ciroldi, Guillaume Thiery, Benoît Schlemmer, Elie Azoulay. Clinical review: specific aspects of acute renal failure in cancer patients. Critical care (London, England). 2006; 10(2):211. doi: 10.1186/cc4907. [PMID: 16677413]
  • I Alexandru Bobulescu, Vangipuram Dwarakanath, Lixian Zou, Jianning Zhang, Michel Baum, Orson W Moe. Glucocorticoids acutely increase cell surface Na+/H+ exchanger-3 (NHE3) by activation of NHE3 exocytosis. American journal of physiology. Renal physiology. 2005 Oct; 289(4):F685-91. doi: 10.1152/ajprenal.00447.2004. [PMID: 15942046]