Nebularine (BioDeep_00000003477)

 

Secondary id: BioDeep_00000398606

human metabolite Endogenous natural product


代谢物信息卡片


2-(hydroxymethyl)-5-(9H-purin-9-yl)oxolane-3,4-diol

化学式: C10H12N4O4 (252.0859)
中文名称: 9 - (Β-D -呋喃核糖)嘌呤, 核糖嘌呤
谱图信息: 最多检出来源 Mus musculus(plant) 3.09%

分子结构信息

SMILES: C1=C2C(=NC=N1)N(C=N2)C3C(C(C(O3)CO)O)O
InChI: InChI=1S/C10H12N4O4/c15-2-6-7(16)8(17)10(18-6)14-4-13-5-1-11-3-12-9(5)14/h1,3-4,6-8,10,15-17H,2H2

描述信息

Nebularine, also known as purine riboside is found in mushrooms. Nebularine can be isolated from the mushroom Clitocybe nebularis (clouded agaric). Nebularine is a nucleoside analog that is used in a variety of enzyme studies.
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
D000970 - Antineoplastic Agents
KEIO_ID P081; [MS2] KO009216
KEIO_ID P081

同义名列表

29 个代谢物同义名

2-(hydroxymethyl)-5-(9H-purin-9-yl)oxolane-3,4-diol; 9-b-D-Ribofuranosyl-9H-purine, 9ci, 8ci; 9-(beta-D-Ribofuranosyl)-9H-purine; 9-beta-D-Ribofuranosyl-9H-purine; 9-(beta -D-Ribofuranosyl)purine; 9beta-D-Ribofuranosyl-9H-purine; Purine-9-beta-D-ribofuranoside; 9-(beta-D-Ribofuranosyl)purine; 9-beta -Ribofuranosylpurine; 9-beta-Ribofuranosylpurine; Purine-1-D-ribofuranoside; 9-Purine ribonucleoside; Purine ribonucleoside; Ribosyl-isopurine; Purine nucleoside; N-D-Ribosylpurine; 3-Deazaadenosine; Purine riboside; Ribosyl-purine; Ribosylpurine; Nebularin (e); Nebularin(e); Nebularin e); Nebularine; Purinosine; 1FKW; PUR; Nebularine; Ribosylpurine



数据库引用编号

28 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

13 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ADA, ANXA5, BCL2, BRAF, CD22, ISG20, MCL1, TP53, XDH
Peripheral membrane protein 2 ADA, ANXA5
Endoplasmic reticulum membrane 2 BCL2, CD4
Nucleus 5 BCL2, BRAF, ISG20, MCL1, TP53
cytosol 9 ADA, ANXA5, BCL2, BRAF, MCL1, NT5E, TP53, UPP1, XDH
centrosome 1 TP53
nucleoplasm 6 ISG20, MCL1, MS4A1, NT5E, TP53, UPP1
Cell membrane 9 ADA, BRAF, CD22, CD4, CD5, CD8A, MS4A1, NT5E, SLC28A2
Lipid-anchor 1 MS4A1
Multi-pass membrane protein 2 MS4A1, SLC28A2
cell junction 1 ADA
cell surface 4 ADA, CD22, MS4A1, NT5E
glutamatergic synapse 1 BRAF
postsynapse 1 BRAF
sarcolemma 1 ANXA5
Lysosome 1 ADA
Presynapse 1 BRAF
plasma membrane 11 ADA, BRAF, CD22, CD4, CD5, CD8A, IFNLR1, ITGAE, MS4A1, NT5E, SLC28A2
Membrane 12 ADA, ANXA5, BCL2, CD22, CD5, IFNLR1, ITGAE, MCL1, MS4A1, NT5E, SLC28A2, TP53
extracellular exosome 4 ANXA5, CD22, MS4A1, NT5E
endoplasmic reticulum 2 BCL2, TP53
extracellular space 3 IL2, MS4A1, XDH
apicolateral plasma membrane 1 SLC28A2
mitochondrion 4 BCL2, BRAF, MCL1, TP53
protein-containing complex 2 BCL2, TP53
intracellular membrane-bounded organelle 1 BRAF
Single-pass type I membrane protein 6 CD22, CD4, CD5, CD8A, IFNLR1, ITGAE
Secreted 1 IL2
extracellular region 3 ANXA5, CD8A, IL2
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 2 BCL2, MCL1
mitochondrial outer membrane 2 BCL2, MCL1
neuronal cell body membrane 1 CD22
[Isoform 2]: Secreted 1 CD8A
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
Extracellular side 1 ADA
Cytoplasmic vesicle lumen 1 ADA
anchoring junction 1 ADA
transcription regulator complex 1 TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 2 BCL2, MCL1
nuclear membrane 1 BCL2
external side of plasma membrane 9 ADA, ANXA5, CD22, CD4, CD5, CD8A, ITGAE, MS4A1, NT5E
nucleolus 2 ISG20, TP53
Cytoplasm, P-body 1 ISG20
P-body 1 ISG20
Early endosome 2 CD22, CD4
recycling endosome 1 CD22
Membrane raft 1 CD4
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 1 ANXA5
Peroxisome 1 XDH
sarcoplasmic reticulum 1 XDH
Nucleus, PML body 1 TP53
PML body 2 ISG20, TP53
collagen-containing extracellular matrix 1 ANXA5
receptor complex 1 CD8A
Zymogen granule membrane 1 ANXA5
neuron projection 1 BRAF
chromatin 1 TP53
brush border membrane 1 SLC28A2
Nucleus, nucleolus 1 ISG20
Lipid-anchor, GPI-anchor 1 NT5E
site of double-strand break 1 TP53
myosin complex 1 MCL1
Nucleus, nucleoplasm 1 MCL1
cell body 1 BRAF
side of membrane 1 NT5E
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
plasma membrane raft 2 CD8A, MS4A1
endoplasmic reticulum lumen 1 CD4
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
vesicle membrane 2 ANXA5, SLC28A2
clathrin-coated endocytic vesicle membrane 1 CD4
Cajal body 1 ISG20
[Isoform 1]: Nucleus 1 TP53
[Isoform 1]: Cell membrane 1 CD8A
Apicolateral cell membrane 1 SLC28A2
coated vesicle 1 SLC28A2
Nucleus, Cajal body 1 ISG20
integrin complex 1 ITGAE
T cell receptor complex 2 CD4, CD8A
endothelial microparticle 1 ANXA5
BAD-BCL-2 complex 1 BCL2
interleukin-28 receptor complex 1 IFNLR1


文献列表

  • Mikiko Kojima, Nobue Makita, Kazuki Miyata, Mika Yoshino, Akira Iwase, Miwa Ohashi, Alicia Surjana, Toru Kudo, Noriko Takeda-Kamiya, Kiminori Toyooka, Akio Miyao, Hirohiko Hirochika, Tsuyu Ando, Ayahiko Shomura, Masahiro Yano, Toshio Yamamoto, Tokunori Hobo, Hitoshi Sakakibara. A cell wall-localized cytokinin/purine riboside nucleosidase is involved in apoplastic cytokinin metabolism in Oryza sativa. Proceedings of the National Academy of Sciences of the United States of America. 2023 Sep; 120(36):e2217708120. doi: 10.1073/pnas.2217708120. [PMID: 37639600]
  • Hana Vylíčilová, Alexandra Husičková, Lukáš Spíchal, Josef Srovnal, Karel Doležal, Ondřej Plíhal, Lucie Plíhalová. C2-substituted aromatic cytokinin sugar conjugates delay the onset of senescence by maintaining the activity of the photosynthetic apparatus. Phytochemistry. 2016 Feb; 122(?):22-33. doi: 10.1016/j.phytochem.2015.12.001. [PMID: 26706318]
  • Suman K Vodnala, Thomas Lundbäck, Esther Yeheskieli, Birger Sjöberg, Anna-Lena Gustavsson, Richard Svensson, Gabriela C Olivera, Anthonius A Eze, Harry P de Koning, Lars G J Hammarström, Martin E Rottenberg. Structure-activity relationships of synthetic cordycepin analogues as experimental therapeutics for African trypanosomiasis. Journal of medicinal chemistry. 2013 Dec; 56(24):9861-73. doi: 10.1021/jm401530a. [PMID: 24283924]
  • Ying Wang, Xiao-Ya Shang, Su-Juan Wang, Shun-Yan Mo, Shuai Li, Yong-Chun Yang, Fei Ye, Jian-Gong Shi, Lan He. Structures, biogenesis, and biological activities of pyrano[4,3-c]isochromen-4-one derivatives from the Fungus Phellinus igniarius. Journal of natural products. 2007 Feb; 70(2):296-9. doi: 10.1021/np060476h. [PMID: 17279797]
  • Richard G Kulka. Cytokinins inhibit epiphyllous plantlet development on leaves of Bryophyllum (Kalanchoë) marnierianum. Journal of experimental botany. 2006; 57(15):4089-98. doi: 10.1093/jxb/erl180. [PMID: 17077184]
  • Yoshihiko Tokuji, Kyoko Kuriyama. Involvement of gibberellin and cytokinin in the formation of embryogenic cell clumps in carrot (Daucus carota). Journal of plant physiology. 2003 Feb; 160(2):133-41. doi: 10.1078/0176-1617-00892. [PMID: 12685029]
  • S D Lindell, B A Moloney, B D Hewitt, C G Earnshaw, P J Dudfield, J E Dancer. The design and synthesis of inhibitors of adenosine 5'-monophosphate deaminase. Bioorganic & medicinal chemistry letters. 1999 Jul; 9(14):1985-90. doi: 10.1016/s0960-894x(99)00298-x. [PMID: 10450967]
  • M W Ritzel, S Y Yao, A M Ng, J R Mackey, C E Cass, J D Young. Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine. Molecular membrane biology. 1998 Oct; 15(4):203-11. doi: 10.3109/09687689709044322. [PMID: 10087507]
  • C H Kim, V E Marquez, D T Mao, D R Haines, J J McCormack. Synthesis of pyrimidin-2-one nucleosides as acid-stable inhibitors of cytidine deaminase. Journal of medicinal chemistry. 1986 Aug; 29(8):1374-80. doi: 10.1021/jm00158a009. [PMID: 3735306]
  • W H Boesken, S Boesken, A Mamier. Human myoglobin: preparation, quantitation and standardization. Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie. 1977 Aug; 171(1):71-8. doi: 10.1007/bf01851590. [PMID: 410087]