Proteinase inhibitor E 64 (BioDeep_00000003377)

 

Secondary id: BioDeep_00001868978

Volatile Flavor Compounds


代谢物信息卡片


3-[[[(1S)-1-[[[4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-(2S,3S)-oxiranecarboxylic acid

化学式: C15H27N5O5 (357.2012092)
中文名称: E-64
谱图信息: 最多检出来源 Mentha canadensis(plant) 12.5%

分子结构信息

SMILES: CC(C)CC(C(=O)NCCCCN=C(N)N)NC(=O)C1C(O1)C(=O)O
InChI: InChI=1S/C15H27N5O5/c1-8(2)7-9(20-13(22)10-11(25-10)14(23)24)12(21)18-5-3-4-6-19-15(16)17/h8-11H,3-7H2,1-2H3,(H,18,21)(H,20,22)(H,23,24)(H4,16,17,19)

描述信息

D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D015853 - Cysteine Proteinase Inhibitors
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
KEIO_ID E015; [MS2] KO008950
KEIO_ID E015

同义名列表

5 个代谢物同义名

3-[[[(1S)-1-[[[4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-(2S,3S)-oxiranecarboxylic acid; Proteinase inhibitor E 64; CID 4641099; e-64; E-64



数据库引用编号

28 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Eman D Elkerdany, Suzanne M Elnassery, Fadwa M Arafa, Sahar Abdel-Fattah Zaki, Rasha F Mady. In vitro effect of a novel protease inhibitor cocktail on Toxoplasma gondii tachyzoites. Experimental parasitology. 2020 Dec; 219(?):108010. doi: 10.1016/j.exppara.2020.108010. [PMID: 33007297]
  • Mohamed Azarkan, Erik Maquoi, François Delbrassine, Raphael Herman, Nasiha M'Rabet, Rafaèle Calvo Esposito, Paulette Charlier, Frédéric Kerff. Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity. Scientific reports. 2020 11; 10(1):19570. doi: 10.1038/s41598-020-76172-5. [PMID: 33177555]
  • Qiangni Liu, Inna Sabirzhanova, Murali K Yanda, Emily A S Bergbower, Clément Boinot, William B Guggino, Liudmila Cebotaru. Rescue of CFTR NBD2 mutants N1303K and S1235R is influenced by the functioning of the autophagosome. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 2018 09; 17(5):582-594. doi: 10.1016/j.jcf.2018.05.016. [PMID: 29936070]
  • Myrna Sabanero López, Lérida L Flores Villavicencio, Karla Soto Arredondo, Gloria Barbosa Sabanero, Julio César Villagómez-Castro, Gustavo Cruz Jiménez, Gerardo Sandoval Bernal, Haydee Torres Guerrero. Proteases of Sporothrix schenckii: Cytopathological effects on a host-cell model. Revista iberoamericana de micologia. 2018 Jan; 35(1):32-38. doi: 10.1016/j.riam.2017.05.003. [PMID: 29221633]
  • C M Kershaw, G Evans, R Rodney, W M C Maxwell. Papain and its inhibitor E-64 reduce camelid semen viscosity without impairing sperm function and improve post-thaw motility rates. Reproduction, fertility, and development. 2017 Jun; 29(6):1107-1114. doi: 10.1071/rd15261. [PMID: 27156102]
  • Gregory Blass, Vladislav Levchenko, Daria V Ilatovskaya, Alexander Staruschenko. Chronic cathepsin inhibition by E-64 in Dahl salt-sensitive rats. Physiological reports. 2016 09; 4(17):. doi: 10.14814/phy2.12950. [PMID: 27597769]
  • Michael W Risør, Line R Thomsen, Kristian W Sanggaard, Tania A Nielsen, Ida B Thøgersen, Marie V Lukassen, Litten Rossen, Irene Garcia-Ferrer, Tibisay Guevara, Carsten Scavenius, Ernst Meinjohanns, F Xavier Gomis-Rüth, Jan J Enghild. Enzymatic and Structural Characterization of the Major Endopeptidase in the Venus Flytrap Digestion Fluid. The Journal of biological chemistry. 2016 Jan; 291(5):2271-87. doi: 10.1074/jbc.m115.672550. [PMID: 26627834]
  • Pei Yin, Jinpeng Jia, Jijun Li, Yan Song, Yiyan Zhang, Fengkun Chen. ABT-737, a Bcl-2 Selective Inhibitor, and Chloroquine Synergistically Kill Renal Cancer Cells. Oncology research. 2016; 24(1):65-72. doi: 10.3727/096504016x14587366983838. [PMID: 27178823]
  • F Mansur, W Luoga, D J Buttle, I R Duce, A Lowe, J M Behnke. The anthelmintic efficacy of natural plant cysteine proteinases against Hymenolepis microstoma in vivo. Journal of helminthology. 2015 Sep; 89(5):601-11. doi: 10.1017/s0022149x14000637. [PMID: 25226116]
  • Yunhe Li, Xiaojie Zhang, Xiuping Chen, Jörg Romeis, Xinming Yin, Yufa Peng. Consumption of Bt rice pollen containing Cry1C or Cry2A does not pose a risk to Propylea japonica (Thunberg) (Coleoptera: Coccinellidae). Scientific reports. 2015 Jan; 5(?):7679. doi: 10.1038/srep07679. [PMID: 25567127]
  • Li Na Liu, Zhong Quan Wang, Xi Zhang, Peng Jiang, Xin Qi, Ruo Dan Liu, Zi Fang Zhang, Jing Cui. Characterization of Spirometra erinaceieuropaei Plerocercoid Cysteine Protease and Potential Application for Serodiagnosis of Sparganosis. PLoS neglected tropical diseases. 2015; 9(6):e0003807. doi: 10.1371/journal.pntd.0003807. [PMID: 26046773]
  • Marcela C de Melo Burger, João Batista Fernandes, Maria F das Graças Fernandes da Silva, Aster Escalante, Jacques Prudhomme, Karine G Le Roch, Mario A Izidoro, Paulo C Vieira. Structures and bioactivities of dihydrochalcones from Metrodorea stipularis. Journal of natural products. 2014 Nov; 77(11):2418-22. doi: 10.1021/np500453x. [PMID: 25375026]
  • Zeng-Xia Wang, Ke-Jian Lin, Jörg Romeis, Yong-Lei Liu, Ze-Wen Liu, Yun-He Li, Yu-Fa Peng. Use of a dietary exposure system for screening of insecticidal compounds for their toxicity to the planthopper Laodelphax striatellus. Insect science. 2014 Oct; 21(5):667-75. doi: 10.1111/1744-7917.12060. [PMID: 24115524]
  • R Benouaret, E Goujon, P Goupil. Grape marc extract causes early perception events, defence reactions and hypersensitive response in cultured tobacco cells. Plant physiology and biochemistry : PPB. 2014 Apr; 77(?):84-9. doi: 10.1016/j.plaphy.2014.01.021. [PMID: 24561714]
  • A M Phiri, D De Pomerai, D J Buttle, J M B Behnke. Developing a rapid throughput screen for detection of nematicidal activity of plant cysteine proteinases: the role of Caenorhabditis elegans cystatins. Parasitology. 2014 Feb; 141(2):164-80. doi: 10.1017/s0031182013001364. [PMID: 24001183]
  • Shaista Ilyas, Muhammad Ilyas, Renier A L van der Hoorn, Sanjay Mathur. Selective conjugation of proteins by mining active proteomes through click-functionalized magnetic nanoparticles. ACS nano. 2013 Nov; 7(11):9655-63. doi: 10.1021/nn402382g. [PMID: 24143894]
  • María E Errasti, Néstor O Caffini, Lilian E Pelzer, Alejandra E Rotelli. Anti-inflammatory activity of Bromelia hieronymi: comparison with bromelain. Planta medica. 2013 Mar; 79(3-4):207-13. doi: 10.1055/s-0032-1328201. [PMID: 23364884]
  • Amaia Zulet, Miriam Gil-Monreal, Joji Grace Villamor, Ana Zabalza, Renier A L van der Hoorn, Mercedes Royuela. Proteolytic pathways induced by herbicides that inhibit amino acid biosynthesis. PloS one. 2013; 8(9):e73847. doi: 10.1371/journal.pone.0073847. [PMID: 24040092]
  • Sruti Dutta, Jiban Kanti Dattagupta, Sampa Biswas. Enhancement of proteolytic activity of a thermostable papain-like protease by structure-based rational design. PloS one. 2013; 8(5):e62619. doi: 10.1371/journal.pone.0062619. [PMID: 23671614]
  • Katia Gindro, Valentine Berger, Sophie Godard, Francine Voinesco, Sylvain Schnee, Olivier Viret, Virginia Alonso-Villaverde. Protease inhibitors decrease the resistance of Vitaceae to Plasmopara viticola. Plant physiology and biochemistry : PPB. 2012 Nov; 60(?):74-80. doi: 10.1016/j.plaphy.2012.07.028. [PMID: 22906813]
  • Thomas Gobbetti, Nicolas Cenac, Jean-Paul Motta, Corinne Rolland, Laurence Martin, Patricia Andrade-Gordon, Martin Steinhoff, Elisabetta Barocelli, Nathalie Vergnolle. Serine protease inhibition reduces post-ischemic granulocyte recruitment in mouse intestine. The American journal of pathology. 2012 Jan; 180(1):141-52. doi: 10.1016/j.ajpath.2011.09.031. [PMID: 22067907]
  • Runqiang Yang, Jiaojiao Song, Zhenxin Gu, Cuijuan Li. Partial purification and characterisation of cysteine protease in wheat germ. Journal of the science of food and agriculture. 2011 Oct; 91(13):2437-42. doi: 10.1002/jsfa.4484. [PMID: 21702054]
  • Sruti Dutta, Debi Choudhury, Jiban K Dattagupta, Sampa Biswas. C-Terminal extension of a plant cysteine protease modulates proteolytic activity through a partial inhibitory mechanism. The FEBS journal. 2011 Sep; 278(17):3012-24. doi: 10.1111/j.1742-4658.2011.08221.x. [PMID: 21707922]
  • S C Yadav, R Kumar, S Kumar, U Tatu, R K Singh, A K Gupta. Identification and characterization of cysteine proteinases of Trypanosoma evansi. Parasitology research. 2011 Sep; 109(3):559-65. doi: 10.1007/s00436-011-2284-9. [PMID: 21350794]
  • Marina S Defferrari, Diogo R Demartini, Thiago B Marcelino, Paulo M Pinto, Celia R Carlini. Insecticidal effect of Canavalia ensiformis major urease on nymphs of the milkweed bug Oncopeltus fasciatus and characterization of digestive peptidases. Insect biochemistry and molecular biology. 2011 Jun; 41(6):388-99. doi: 10.1016/j.ibmb.2011.02.008. [PMID: 21377528]
  • Stefanie Engelbrecht, Eva Kaltenborn, Matthias Griese, Suncana Kern. The surfactant lipid transporter ABCA3 is N-terminally cleaved inside LAMP3-positive vesicles. FEBS letters. 2010 Oct; 584(20):4306-12. doi: 10.1016/j.febslet.2010.09.026. [PMID: 20863830]
  • Sadaf Khan, Giti Verma, Samir Sharma. A novel Ca2+-activated protease from germinating Vigna radiata seeds and its role in storage protein mobilization. Journal of plant physiology. 2010 Jul; 167(11):855-61. doi: 10.1016/j.jplph.2010.01.010. [PMID: 20149479]
  • Marco Túlio R Gomes, Andréia P Turchetti, Miriam T P Lopes, Carlos E Salas. Stimulation of fibroblast proliferation by the plant cysteine protease CMS2MS2 is independent of its proteolytic activity and requires ERK activation. Biological chemistry. 2009 Dec; 390(12):1285-91. doi: 10.1515/bc.2009.137. [PMID: 19747075]
  • Zheming Wang, Christian Gu, Tom Colby, Takayuki Shindo, Rengarajan Balamurugan, Herbert Waldmann, Markus Kaiser, Renier A L van der Hoorn. Beta-lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana. Nature chemical biology. 2008 Sep; 4(9):557-63. doi: 10.1038/nchembio.104. [PMID: 18660805]
  • Iu A Smirnova, L V Kordiukova, M V Serebriakova, I Iu Filippova, E N Lysogorskaia, L A Baratova. [Flu virion as a substrate for proteolytic enzymes]. Bioorganicheskaia khimiia. 2008 May; 34(3):409-15. doi: 10.1134/s1068162008030205. [PMID: 18672693]
  • Hendra Gunawan, Toshiro Takai, Shigaku Ikeda, Ko Okumura, Hideoki Ogawa. Protease activity of allergenic pollen of cedar, cypress, juniper, birch and ragweed. Allergology international : official journal of the Japanese Society of Allergology. 2008 Mar; 57(1):83-91. doi: 10.2332/allergolint.o-07-507. [PMID: 18209508]
  • G Stepek, R H C Curtis, B R Kerry, P R Shewry, S J Clark, A E Lowe, I R Duce, D J Buttle, J M Behnke. Nematicidal effects of cysteine proteinases against sedentary plant parasitic nematodes. Parasitology. 2007 Nov; 134(Pt 12):1831-8. doi: 10.1017/s0031182007003289. [PMID: 17640402]
  • Jian J Duan, Joseph Huesing, Debra Teixeira. Development of tier-I toxicity assays for Orius insidiosus (Heteroptera: Anthocoridae) for assessing the risk of plant-incorporated protectants to nontarget heteropterans. Environmental entomology. 2007 Aug; 36(4):982-8. doi: 10.1603/0046-225x(2007)36[982:dottaf]2.0.co;2. [PMID: 17716490]
  • Kiminori Toyooka, Yuji Moriyasu, Yumi Goto, Masaki Takeuchi, Hiroo Fukuda, Ken Matsuoka. Protein aggregates are transported to vacuoles by a macroautophagic mechanism in nutrient-starved plant cells. Autophagy. 2006 Apr; 2(2):96-106. doi: 10.4161/auto.2.2.2366. [PMID: 16874101]
  • André L S Santos, Claudia M d'Avila-Levy, Felipe A Dias, Rachel O Ribeiro, Fernanda M Pereira, Camila G R Elias, Thaïs Souto-Padrón, Angela H C S Lopes, Celuta S Alviano, Marta H Branquinha, Rosangela M A Soares. Phytomonas serpens: cysteine peptidase inhibitors interfere with growth, ultrastructure and host adhesion. International journal for parasitology. 2006 Jan; 36(1):47-56. doi: 10.1016/j.ijpara.2005.09.004. [PMID: 16310789]
  • Ji Young Kim, Hyun Jong Yang, Kwang Sig Kim, Young Bae Chung. Partial characterization of a 29 kDa cysteine protease purified from Taenia solium metacestodes. The Korean journal of parasitology. 2005 Dec; 43(4):157-60. doi: 10.3347/kjp.2005.43.4.157. [PMID: 16340305]
  • Henrietta C E Rooney, John W Van't Klooster, Renier A L van der Hoorn, Matthieu H A J Joosten, Jonathan D G Jones, Pierre J G M de Wit. Cladosporium Avr2 inhibits tomato Rcr3 protease required for Cf-2-dependent disease resistance. Science (New York, N.Y.). 2005 Jun; 308(5729):1783-6. doi: 10.1126/science.1111404. [PMID: 15845874]
  • Prabal K Chatterjee, Zoran Todorovic, Ahila Sivarajah, Helder Mota-Filipe, Paul A J Brown, Keith N Stewart, Emanuela Mazzon, Salvatore Cuzzocrea, Christoph Thiemermann. Inhibitors of calpain activation (PD150606 and E-64) and renal ischemia-reperfusion injury. Biochemical pharmacology. 2005 Apr; 69(7):1121-31. doi: 10.1016/j.bcp.2005.01.003. [PMID: 15763548]
  • G Stepek, D J Buttle, I R Duce, A Lowe, J M Behnke. Assessment of the anthelmintic effect of natural plant cysteine proteinases against the gastrointestinal nematode, Heligmosomoides polygyrus, in vitro. Parasitology. 2005 Feb; 130(Pt 2):203-11. doi: 10.1017/s0031182004006225. [PMID: 15727070]
  • André Luis Souza Dos Santos, Rosangela Maria de Araújo Soares. Candida guilliermondii isolated from HIV-infected human secretes a 50 kDa serine proteinase that cleaves a broad spectrum of proteinaceous substrates. FEMS immunology and medical microbiology. 2005 Jan; 43(1):13-20. doi: 10.1016/j.femsim.2004.06.022. [PMID: 15607631]
  • Koh Kusaka, Yasuomi Tada, Teppei Shigemi, Masaru Sakamoto, Hitoshi Nakayashiki, Yukio Tosa, Shigeyuki Mayama. Coordinate involvement of cysteine protease and nuclease in the executive phase of plant apoptosis. FEBS letters. 2004 Dec; 578(3):363-7. doi: 10.1016/j.febslet.2004.10.101. [PMID: 15589846]
  • Igor Stern, Norbert Schaschke, Luis Moroder, Dusan Turk. Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft. The Biochemical journal. 2004 Jul; 381(Pt 2):511-7. doi: 10.1042/bj20040237. [PMID: 15084146]
  • Daniel Rivard, Conrad Cloutier, Dominique Michaud. Colorado potato beetles show differential digestive compensatory responses to host plants expressing distinct sets of defense proteins. Archives of insect biochemistry and physiology. 2004 Mar; 55(3):114-23. doi: 10.1002/arch.10136. [PMID: 14981656]
  • J Rozman-Pungercar, N Kopitar-Jerala, M Bogyo, D Turk, O Vasiljeva, I Stefe, P Vandenabeele, D Brömme, V Puizdar, M Fonović, M Trstenjak-Prebanda, I Dolenc, V Turk, B Turk. Inhibition of papain-like cysteine proteases and legumain by caspase-specific inhibitors: when reaction mechanism is more important than specificity. Cell death and differentiation. 2003 Aug; 10(8):881-8. doi: 10.1038/sj.cdd.4401247. [PMID: 12867995]
  • Takako Sahara, Kanami Itoh, Kazuhiro Debari, Takahisa Sasaki. Specific biological functions of vacuolar-type H(+)-ATPase and lysosomal cysteine proteinase, cathepsin K, in osteoclasts. The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology. 2003 Feb; 270(2):152-61. doi: 10.1002/ar.a.10020. [PMID: 12524690]
  • Maryse Laloi, James McCarthy, Olivia Morandi, Christof Gysler, Peter Bucheli. Molecular and biochemical characterisation of two aspartic proteinases TcAP1 and TcAP2 from Theobroma cacao seeds. Planta. 2002 Sep; 215(5):754-62. doi: 10.1007/s00425-002-0818-1. [PMID: 12244440]
  • Julia Krüger, Colwyn M Thomas, Catherine Golstein, Mark S Dixon, Matthew Smoker, Saijun Tang, Lonneke Mulder, Jonathan D G Jones. A tomato cysteine protease required for Cf-2-dependent disease resistance and suppression of autonecrosis. Science (New York, N.Y.). 2002 Apr; 296(5568):744-7. doi: 10.1126/science.1069288. [PMID: 11976458]
  • Roberta Castino, Deborah Pace, Marina Démoz, Marco Gargiulo, Chiara Ariatta, Elisabetta Raiteri, Ciro Isidoro. Lysosomal proteases as potential targets for the induction of apoptotic cell death in human neuroblastomas. International journal of cancer. 2002 Feb; 97(6):775-9. doi: 10.1002/ijc.10139. [PMID: 11857353]
  • M Kajita, Y Itoh, T Chiba, H Mori, A Okada, H Kinoh, M Seiki. Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration. The Journal of cell biology. 2001 May; 153(5):893-904. doi: 10.1083/jcb.153.5.893. [PMID: 11381077]
  • S E Wilhite, T C Elden, J Brzin, A C Smigocki. Inhibition of cysteine and aspartyl proteinases in the alfalfa weevil midgut with biochemical and plant-derived proteinase inhibitors. Insect biochemistry and molecular biology. 2000 Dec; 30(12):1181-8. doi: 10.1016/s0965-1748(00)00095-3. [PMID: 11044664]
  • H D Guthrie, W M Garrett, B S Cooper. Inhibition of apoptosis in cultured porcine granulosa cells by inhibitors of caspase and serine protease activity. Theriogenology. 2000 Sep; 54(5):731-40. doi: 10.1016/s0093-691x(00)00386-1. [PMID: 11101034]
  • D Greenbaum, K F Medzihradszky, A Burlingame, M Bogyo. Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools. Chemistry & biology. 2000 Aug; 7(8):569-81. doi: 10.1016/s1074-5521(00)00014-4. [PMID: 11048948]
  • P K Selbo, K Sandvig, V Kirveliene, K Berg. Release of gelonin from endosomes and lysosomes to cytosol by photochemical internalization. Biochimica et biophysica acta. 2000 Jul; 1475(3):307-13. doi: 10.1016/s0304-4165(00)00082-9. [PMID: 10913830]
  • M Pernas, I Sanchez-Ramos, R Sanchez-Monge, M Lombardero, C Arteaga, P Castañera, G Salcedo. Der p 1 and Der f 1, the highly related and major allergens from house dust mites, are differentially affected by a plant cystatin. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2000 Jul; 30(7):972-8. doi: 10.1046/j.1365-2222.2000.00845.x. [PMID: 10848919]
  • S Johnson, A Knox. Autocrine production of matrix metalloproteinase-2 is required for human airway smooth muscle proliferation. The American journal of physiology. 1999 12; 277(6):L1109-17. doi: 10.1152/ajplung.1999.277.6.l1109. [PMID: 10600880]
  • A Vardi, I Berman-Frank, T Rozenberg, O Hadas, A Kaplan, A Levine. Programmed cell death of the dinoflagellate Peridinium gatunense is mediated by CO(2) limitation and oxidative stress. Current biology : CB. 1999 Sep; 9(18):1061-4. doi: 10.1016/s0960-9822(99)80459-x. [PMID: 10508616]
  • A J Walker, P E Urwin, H J Atkinson, P Brain, D M Glen, P R Shewry. Transgenic Arabidopsis leaf tissue expressing a modified oryzacystatin shows resistance to the field slug Deroceras reticulatum (Müller). Transgenic research. 1999 Apr; 8(2):95-103. doi: 10.1023/a:1008814317199. [PMID: 10481309]
  • E Govrin, A Levine. Purification of active cysteine proteases by affinity chromatography with attached E-64 inhibitor. Protein expression and purification. 1999 Apr; 15(3):247-50. doi: 10.1006/prep.1999.1033. [PMID: 10092483]
  • K M Thrailkill, S Kumar, C K Rosenberg, K J Auten, J L Fowlkes. Characterization of matrix metalloproteinases in human urine: alterations during adolescence. Pediatric nephrology (Berlin, Germany). 1999 Apr; 13(3):223-9. doi: 10.1007/s004670050597. [PMID: 10353410]
  • J D Schwartz, P Shamamian, S Monea, D Whiting, S G Marcus, A C Galloway, P Mignatti. Activation of tumor cell matrix metalloproteinase-2 by neutrophil proteinases requires expression of membrane-type 1 matrix metalloproteinase. Surgery. 1998 Aug; 124(2):232-8. doi: 10.1016/s0039-6060(98)70125-4. [PMID: 9706143]
  • T I Vlasova, B F Vanyushin. DNA methylation by wheat cytosine DNA methyltransferase: modulation by protease inhibitor E-64. Biochemistry and molecular biology international. 1998 Jun; 45(1):145-53. doi: 10.1080/15216549800202512. [PMID: 9635138]
  • H Sakurai, T Tsukamoto, C A Kjelsberg, L G Cantley, S K Nigam. EGF receptor ligands are a large fraction of in vitro branching morphogens secreted by embryonic kidney. The American journal of physiology. 1997 Sep; 273(3 Pt 2):F463-72. doi: 10.1152/ajprenal.1997.273.3.f463. [PMID: 9321921]
  • H A Franch, P V Curtis, W E Mitch. Mechanisms of renal tubular cell hypertrophy: mitogen-induced suppression of proteolysis. The American journal of physiology. 1997 Sep; 273(3 Pt 1):C843-51. doi: 10.1152/ajpcell.1997.273.3.c843. [PMID: 9316404]
  • E Svensjö, F Z Cyrino, L Juliano, J Scharfstein. Plasma leakage induced in postcapillary venules by the major cysteine-proteinase from Trypanosoma cruzi and its modulation by H1-blocker mepyramine. Microvascular research. 1997 Jul; 54(1):93-7. doi: 10.1006/mvre.1997.2020. [PMID: 9245650]
  • M Vergelli, V Pinet, A B Vogt, M Kalbus, M Malnati, P Riccio, E O Long, R Martin. HLA-DR-restricted presentation of purified myelin basic protein is independent of intracellular processing. European journal of immunology. 1997 Apr; 27(4):941-51. doi: 10.1002/eji.1830270421. [PMID: 9130648]
  • M R Groves, M A Taylor, M Scott, N J Cummings, R W Pickersgill, J A Jenkins. The prosequence of procaricain forms an alpha-helical domain that prevents access to the substrate-binding cleft. Structure (London, England : 1993). 1996 Oct; 4(10):1193-203. doi: 10.1016/s0969-2126(96)00127-x. [PMID: 8939744]
  • M Michetti, F Salamino, I Tedesco, M Averna, R Minafra, E Melloni, S Pontremoli. Autolysis of human erythrocyte calpain produces two active enzyme forms with different cell localization. FEBS letters. 1996 Aug; 392(1):11-5. doi: 10.1016/0014-5793(96)00775-2. [PMID: 8769305]
  • N A Katerelos, M A Taylor, M Scott, P W Goodenough, R W Pickersgill. Crystal structure of a caricain D158E mutant in complex with E-64. FEBS letters. 1996 Aug; 392(1):35-9. doi: 10.1016/0014-5793(96)00697-7. [PMID: 8769310]
  • X Yang, R G Schnellmann. Proteinases in renal cell death. Journal of toxicology and environmental health. 1996 Jul; 48(4):319-32. doi: 10.1080/009841096161221. [PMID: 8691504]
  • V Bongers, C H Konings, A M Grijpma, I Steen, B J Braakhuis, G B Snow. Serum proteinase activities in head and neck squamous cell carcinoma patients. Anticancer research. 1995 Nov; 15(6B):2763-6. doi: NULL. [PMID: 8669860]
  • V P Knutson, P V Donnelly, Y Balba, M Lopez-Reyes. Insulin resistance is mediated by a proteolytic fragment of the insulin receptor. The Journal of biological chemistry. 1995 Oct; 270(42):24972-81. doi: 10.1074/jbc.270.42.24972. [PMID: 7559625]
  • D Quiec, C Mazière, M Auclair, R Santus, J Gardette, G Redziniak, J Franchi, L Dubertret, J C Mazière. Lovastatin enhances the photocytotoxicity of UVA radiation towards cultured N.C.T.C. 2544 human keratinocytes: prevention by cholesterol supplementation and by a cathepsin inhibitor. The Biochemical journal. 1995 Aug; 310 ( Pt 1)(?):305-9. doi: 10.1042/bj3100305. [PMID: 7646460]
  • J P Montenez, B K Kishore, P Maldague, P M Tulkens. Leupeptin and E-64, inhibitors of cysteine proteinases, prevent gentamicin-induced lysosomal phospholipidosis in cultured rat fibroblasts. Toxicology letters. 1994 Sep; 73(3):201-8. doi: 10.1016/0378-4274(94)90059-0. [PMID: 8091428]
  • B M Wagner, R A Smith, P J Coles, L J Copp, M J Ernest, A Krantz. In vivo inhibition of cathepsin B by peptidyl (acyloxy)methyl ketones. Journal of medicinal chemistry. 1994 Jun; 37(12):1833-40. doi: 10.1021/jm00038a012. [PMID: 8021922]
  • L L Leon, R M Temporal, M J Soares, G Grimaldi Júnior. Proteinase activities during temperature-induced stage differentiation of species complexes of Leishmania. Acta tropica. 1994 Apr; 56(4):289-98. doi: 10.1016/0001-706x(94)90100-7. [PMID: 8023752]
  • B L Kelsall, J I Ravdin. Degradation of human IgA by Entamoeba histolytica. The Journal of infectious diseases. 1993 Nov; 168(5):1319-22. doi: 10.1093/infdis/168.5.1319. [PMID: 8228372]
  • M A Korsten, J W Długosz. Cathepsin B inhibition in two models of acute pancreatitis. International journal of pancreatology : official journal of the International Association of Pancreatology. 1993 Oct; 14(2):149-55. doi: 10.1007/bf02786121. [PMID: 7506743]
  • A A Kembhavi, D J Buttle, C G Knight, A J Barrett. The two cysteine endopeptidases of legume seeds: purification and characterization by use of specific fluorometric assays. Archives of biochemistry and biophysics. 1993 Jun; 303(2):208-13. doi: 10.1006/abbi.1993.1274. [PMID: 8512309]
  • M J Boyer, I Horn, R A Firestone, D Steele-Norwood, I F Tannock. pH dependent cytotoxicity of N-dodecylimidazole: a compound that acquires detergent properties under acidic conditions. British journal of cancer. 1993 Jan; 67(1):81-7. doi: 10.1038/bjc.1993.13. [PMID: 8427783]
  • D A Henriquez, N Perez, A Pance, C Bradley. Mechanisms of protein degradation in Trypanosoma cruzi. Biological research. 1993; 26(1-2):151-7. doi: NULL. [PMID: 7670528]
  • K Saito, H Kaneko, N Isobe, I Nakatsuka, A Yoshitake, H Yamada. Differences in alpha 2u-globulins increased in male rat kidneys following treatment with several alpha 2u-globulin accumulating agents: cystein protease(s) play(s) an important role in production of kidney-type-alpha 2u-globulin. Toxicology. 1992 Nov; 76(2):177-86. doi: 10.1016/0300-483x(92)90163-9. [PMID: 1281346]
  • N Sloot, M Thomas, R Marre, S Gatermann. Purification and characterisation of elastase from Staphylococcus epidermidis. Journal of medical microbiology. 1992 Sep; 37(3):201-5. doi: 10.1099/00222615-37-3-201. [PMID: 1518036]
  • J P Jani, J S Mistry, G Morris, P Davies, J S Lazo, S M Sebti. In vivo circumvention of human colon carcinoma resistance to bleomycin. Cancer research. 1992 May; 52(10):2931-7. doi: NULL. [PMID: 1374681]
  • S M Redwood, B C Liu, R E Weiss, D E Hodge, M J Droller. Abrogation of the invasion of human bladder tumor cells by using protease inhibitor(s). Cancer. 1992 Mar; 69(5):1212-9. doi: 10.1002/cncr.2820690524. [PMID: 1739920]
  • J P Jani, J S Mistry, G Morris, J S Lazo, S M Sebti. In vivo sensitization of human lung carcinoma to bleomycin by the cysteine proteinase inhibitor E-64. Oncology research. 1992; 4(2):59-63. doi: NULL. [PMID: 1375852]
  • P D Wilson, P A Hartz. Mechanisms of cyclosporine A toxicity in defined cultures of renal tubule epithelia: a role for cysteine proteases. Cell biology international reports. 1991 Dec; 15(12):1243-58. doi: 10.1016/0309-1651(91)90096-2. [PMID: 1802407]
  • D Gingras, P Ménard, R Béliveau. Protein carboxyl methylation in kidney brush-border membranes. Biochimica et biophysica acta. 1991 Jul; 1066(2):261-7. doi: 10.1016/0005-2736(91)90196-f. [PMID: 1854790]
  • L Denek, J S Schwegler, R M Schaefer, A Heidland. Parathyroid hormone increases thiol proteinase activity by activation of protein kinase C in cultured kidney tubule cells (OK). FEBS letters. 1990 Aug; 269(1):226-8. doi: 10.1016/0014-5793(90)81160-p. [PMID: 2117554]
  • J M Zdolsek, G M Olsson, U T Brunk. Photooxidative damage to lysosomes of cultured macrophages by acridine orange. Photochemistry and photobiology. 1990 Jan; 51(1):67-76. doi: 10.1111/j.1751-1097.1990.tb01685.x. [PMID: 2304980]
  • S F Chen. Teratogenic effects of combined use of anti-kidney serum and E-64 in the rat. Acta paediatrica Japonica : Overseas edition. 1989 Dec; 31(6):685-9. doi: 10.1111/j.1442-200x.1989.tb01380.x. [PMID: 2516394]
  • W H Baricos, S E O'Connor, S L Cortez, L T Wu, S V Shah. The cysteine proteinase inhibitor, E-64, reduces proteinuria in an experimental model of glomerulonephritis. Biochemical and biophysical research communications. 1988 Sep; 155(3):1318-23. doi: 10.1016/s0006-291x(88)81285-3. [PMID: 3178811]
  • M Tamai, K Matsumoto, S Omura, I Koyama, Y Ozawa, K Hanada. In vitro and in vivo inhibition of cysteine proteinases by EST, a new analog of E-64. Journal of pharmacobio-dynamics. 1986 Aug; 9(8):672-7. doi: 10.1248/bpb1978.9.672. [PMID: 3023601]
  • K Komatsu, K Inazuki, J Hosoya, S Satoh. Beneficial effect of new thiol protease inhibitors, epoxide derivatives, on dystrophic mice. Experimental neurology. 1986 Jan; 91(1):23-9. doi: 10.1016/0014-4886(86)90022-1. [PMID: 3940877]
  • S Hashida, E Kominami, N Katunuma. Inhibitions of cathepsin B and cathepsin L by E-64 in vivo. II. Incorporation of [3H]E-64 into rat liver lysosomes in vivo. Journal of biochemistry. 1982 Apr; 91(4):1373-80. doi: 10.1093/oxfordjournals.jbchem.a133825. [PMID: 7096292]
  • A J Barrett, A A Kembhavi, M A Brown, H Kirschke, C G Knight, M Tamai, K Hanada. L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L. The Biochemical journal. 1982 Jan; 201(1):189-98. doi: 10.1042/bj2010189. [PMID: 7044372]