2,4(1H,3H)-Pyrimidinedione, 5-fluoro-1-(tetrahydro-2-furanyl)-, (R)- (BioDeep_00000003257)
Secondary id: BioDeep_00000406252
human metabolite blood metabolite
代谢物信息卡片
2,4(1H,3H)-Pyrimidinedione, 5-fluoro-1-(tetrahydro-2-furanyl)-, (R)-
化学式: C8H9FN2O3 (200.0597)
中文名称: 5-氟-1-(四氢-2-糠基)尿嘧啶, 替加氟
谱图信息:
最多检出来源 Homo sapiens(blood) 45.03%
分子结构信息
SMILES: C1CC(OC1)N2C=C(C(=O)NC2=O)F
InChI: InChI=1S/C8H9FN2O3/c9-5-4-11(6-2-1-3-14-6)8(13)10-7(5)12/h4,6H,1-3H2,(H,10,12,13)
描述信息
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01B - Antimetabolites > L01BC - Pyrimidine analogues
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C272 - Antimetabolite
C471 - Enzyme Inhibitor > C2021 - Thymidylate Synthase Inhibitor
D009676 - Noxae > D000963 - Antimetabolites
D000970 - Antineoplastic Agents
Same as: D01244
Tegafur (FT 207; NSC 148958) is a chemotherapeutic 5-FU proagent used in the treatment of cancers; is a component of tegafur-uracil.
同义名列表
19 个代谢物同义名
2,4(1H,3H)-Pyrimidinedione, 5-fluoro-1-(tetrahydro-2-furanyl)-, (R)-; 5-fluoro-1-(oxolan-2-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione; 5-Fluoro-1-(tetrahydro-2-furanyl)-2,4-pyrimidinedione; 1-(Tetrahydro-2-furanyl)-5-fluorouracil; N1-(2-Tetrahydrofuryl)-5-fluorouracil; 1-(2-Tetrahydrofuryl)-5-fluorouracil; Sunfural S; Fluorofur; Florafur; Futraful; Ftorafur; Uftoral; Atillon; tegafur; Utefos; FT 207; NSC 148958; Tegafur; Tegafur
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:32188
- KEGG: C12673
- PubChem: 5386
- HMDB: HMDB0246215
- Metlin: METLIN69467
- DrugBank: DB09256
- ChEMBL: CHEMBL20883
- Wikipedia: Tegafur
- MeSH: Tegafur
- chemspider: 5193
- CAS: 1189456-27-6
- CAS: 17902-23-7
- CAS: 82294-77-7
- PMhub: MS000008648
- PubChem: 583063
- NIKKAJI: J4.543H
- medchemexpress: HY-17400
- KNApSAcK: 32188
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Eisuke Booka, Chiyo K Imamura, Masashi Takeuchi, Hirofumi Kawakubo, Hiroya Takeuchi, Yusuke Tanigawara, Yuko Kitagawa, Narikazu Boku. Evaluation of clinical validity of an S-1 dosage formula based on renal function using data of the SPIRITS and the G-SOX trials.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association.
2022 07; 25(4):770-782. doi:
10.1007/s10120-022-01291-z. [PMID: 35357635] - Parmeshwar Vitthal Gavande, Priyanka Nath, Krishan Kumar, Nazneen Ahmed, Carlos M G A Fontes, Arun Goyal. Highly efficient, processive and multifunctional recombinant endoglucanase RfGH5_4 from Ruminococcus flavefaciens FD-1 v3 for recycling lignocellulosic plant biomasses.
International journal of biological macromolecules.
2022 Jun; 209(Pt A):801-813. doi:
10.1016/j.ijbiomac.2022.04.059. [PMID: 35421411] - Veerle Casneuf, Ivan Borbath, Marc Van den Eynde, Yolanda Verheezen, Wim Demey, Alain G Verstraete, Kathleen Bm Claes, Vincent Haufroid, Karen P Geboes. Joint Belgian recommendation on screening for DPD-deficiency in patients treated with 5-FU, capecitabine (and tegafur).
Acta clinica Belgica.
2022 Apr; 77(2):346-352. doi:
10.1080/17843286.2020.1870855. [PMID: 33423619] - Satoru Mitsuboshi, Takahiro Niimura, Masaki Yoshino, Yoshika Sakamoto, Yoshito Zamami, Keisuke Ishizawa. Fluoropyridmidine use and hypertriglyceridemia among Japanese patients: analysis of adverse event database.
International journal of clinical pharmacy.
2022 Feb; 44(1):260-263. doi:
10.1007/s11096-021-01324-0. [PMID: 34482500] - Qingqian Zhang, Yue Qian, Ying Yin. Comparison of S-1-based vs. capecitabine-based adjuvant chemotherapy for patients with gastric cancer: a systematic review and meta-analysis.
European journal of clinical pharmacology.
2021 Dec; 77(12):1791-1804. doi:
10.1007/s00228-021-03187-w. [PMID: 34275019] - Yoshitaka Saito, Yoh Takekuma, Satoshi Takeuchi, Yoshito Komatsu, Mitsuru Sugawara. Severe hypertriglyceridemia induced by S-1: Subsequent case series of four patients and further review of the literature.
International journal of clinical pharmacology and therapeutics.
2021 Dec; 59(12):787-793. doi:
10.5414/cp204091. [PMID: 34503646] - Satoshi Kobayashi, Makoto Ueno, Gakuto Ogawa, Akira Fukutomi, Masafumi Ikeda, Takuji Okusaka, Tosiya Sato, Yoshinori Ito, Tomohiro Kadota, Tatsuya Ioka, Kazuya Sugimori, Naohiro Sata, Shoji Nakamori, Kyoko Shimizu, Nobumasa Mizuno, Hiroshi Ishii, Junji Furuse. Impact of Renal Function on S-1 + Radiotherapy for Locally Advanced Pancreatic Cancer: An Integrated Analysis of Data From 2 Clinical Trials.
Pancreas.
2021 08; 50(7):965-971. doi:
10.1097/mpa.0000000000001879. [PMID: 34629456] - Chih-Chieh Yen, Yan-Shen Shan, Ying-Jui Chao, Ting-Kai Liao, I-Shu Chen, Hsuan-Yi Huang, I-Ting Liu, Chia-Jui Yen. Surgery alone, adjuvant tegafur/gimeracil/octeracil (S-1), or platinum-based chemotherapies for resectable gastric cancer: real-world experience and a propensity score matching analysis.
BMC cancer.
2021 Jul; 21(1):796. doi:
10.1186/s12885-021-08487-z. [PMID: 34243732] - Yoshitaka Saito, Yoh Takekuma, Yoshito Komatsu, Mitsuru Sugawara. Hypertriglyceridemia induced by S-1: A novel case report and review of the literature.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.
2021 Jun; 27(4):1020-1025. doi:
10.1177/1078155220956691. [PMID: 32936722] - Dazhou Xu, Zhimei Zhang, Shuxian Zhang, Xinjian Fang, Lei Wang, Qiuling Li. Efficacy of trastuzumab combined with SOX or IP chemotherapy regimen in the treatment of advanced gastric cancer.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology.
2021 May; 26(3):932-939. doi:
. [PMID: 34268956] - Hui Chen, Liangjun Xue, Lihong Liu, Pengfei Li. Efficacy of apatinib combined with tegafur gimeracil and oteracil potassium in the second-line treatment of advanced gastric cancer.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology.
2021 May; 26(3):917-923. doi:
. [PMID: 34268954] - Shozo Mori, Taku Aoki, Yuhki Sakuraoka, Takayuki Shimizu, Takamune Yamaguchi, Kyung-Hwa Park, Takatsugu Matsumoto, Takayuki Shiraki, Yukihiro Iso, Keiichi Kubota. Predictors of Poor Pathological Response to Neoadjuvant Gemcitabine Plus S-1 Chemotherapy in Patients With Pancreatic Ductal Adenocarcinoma.
Pancreas.
2021 May; 50(5):744-750. doi:
10.1097/mpa.0000000000001826. [PMID: 34016892] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - B W Xie, L Zang, J J Ma, J Sun, X Yang, M L Wang, A G Lu, W G Hu, M H Zheng. [Safety and effectiveness of oxaliplatin combined with capecitabine or oxaliplatin combined with S-1 neoadjuvant chemotherapy in the treatment of advanced gastric cancer].
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery.
2021 Feb; 24(2):138-144. doi:
10.3760/cma.j.cn.441530-20200721-00433. [PMID: 33508919] - Ken Shiraiwa, Yosuke Suzuki, Hiroki Uchida, Yukio Iwashita, Ryota Tanaka, Motoshi Iwao, Kazuhiro Tada, Teijiro Hirashita, Takashi Masuda, Yuichi Endo, Masafumi Inomata, Hiroki Itoh. Simultaneous quantification method for 5-FU, uracil, and tegafur using UPLC-MS/MS and clinical application in monitoring UFT/LV combination therapy after hepatectomy.
Scientific reports.
2021 02; 11(1):3132. doi:
10.1038/s41598-021-82908-8. [PMID: 33542452] - Hidenori Ando, Kiyoshi Eshima, Tatsuhiro Ishida. Neutralization of Acidic Tumor Microenvironment (TME) with Daily Oral Dosing of Sodium Potassium Citrate (K/Na Citrate) Increases Therapeutic Effect of Anti-cancer Agent in Pancreatic Cancer Xenograft Mice Model.
Biological & pharmaceutical bulletin.
2021; 44(2):266-270. doi:
10.1248/bpb.b20-00825. [PMID: 33518679] - Peiyu Wen, Haibo Wang, Tengyang Ni, Xiaojun Dai, Zewen Chu, Shuang Ma, Liangliang Xiang, Zhen Zhou, Yayun Qian, Masataka Sunagawa, Yanqing Liu. A Study on the Effect and Mechanism of Xiaoaiping (XAP) Injection and S-1 Combination Therapy in Inhibiting the Invasion and Metastasis of Human GC Cells.
Anti-cancer agents in medicinal chemistry.
2021; 21(8):1037-1046. doi:
10.2174/1871520620666200918100422. [PMID: 32951585] - Jianfeng Yang, Jing Wang, Haibin Zhou, Yucheng Wang, Haitao Huang, Hangbin Jin, Qifeng Lou, Raj J Shah, Xiaofeng Zhang. Endoscopic radiofrequency ablation plus a novel oral 5-fluorouracil compound versus radiofrequency ablation alone for unresectable extrahepatic cholangiocarcinoma.
Gastrointestinal endoscopy.
2020 12; 92(6):1204-1212.e1. doi:
10.1016/j.gie.2020.04.075. [PMID: 32437711] - Naoya Toriu, Naoki Sawa, Aya Imafuku, Eiko Hasegawa, Akinari Sekine, Hiroki Mizuno, Masayuki Yamanouchi, Rikako Hiramatsu, Noriko Hayami, Junichi Hoshino, Masahiro Kawada, Tatsuya Suwabe, Kenichi Ohashi, Takeshi Fujii, Yoshifumi Ubara. Rapidly progressive glomerulonephritis caused by tegafur/gimeracil/oteracil resulted in diabetes nephropathy, in a patient with minor risk of diabetes nephropathy: a case report.
CEN case reports.
2020 11; 9(4):347-353. doi:
10.1007/s13730-020-00485-7. [PMID: 32378178] - Shinji Kobuchi, Eisuke Matsumura, Yukako Ito, Toshiyuki Sakaeda. Population Pharmacokinetic Model-Based Evaluation of Circadian Variations in Plasma 5-Fluorouracil Concentrations During Long-Term Infusion in Rats: A Comparison With Oral Anticancer Prodrugs.
Journal of pharmaceutical sciences.
2020 07; 109(7):2356-2361. doi:
10.1016/j.xphs.2020.04.005. [PMID: 32311368] - Xiao-Cui Hong, Qi-Lian Liang, Xing-Bo Luo, Ke-Hui Hu, Hai-Xia Yang, Wen-Ting Ou, Hui-Jie Zhang. Clinical study of XiangShaLiuJunZi decoction combined with S-1 as maintenance therapy for stage III or IV gastric carcinoma and colorectal carcinoma.
Medicine.
2020 May; 99(19):e20081. doi:
10.1097/md.0000000000020081. [PMID: 32384478] - Po-Chih Yang, Kai-Wen Huang, Uei Pua, Man-Deuk Kim, Sheng-Ping Li, Xiao-Yong Li, Po-Chin Liang. Prognostic factor analysis of irreversible electroporation for locally advanced pancreatic cancer - A multi-institutional clinical study in Asia.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.
2020 05; 46(5):811-817. doi:
10.1016/j.ejso.2019.12.006. [PMID: 31839436] - Ryohei Wada, Yusuke Akamaru, Noriko Wada, Daiki Hokkoku, Ryo Ikeshima, Koji Munakata, Daisuke Takiuchi, Osakuni Morimoto, Hirofumi Ota, Kunitaka Shibata. [Case of Gastric Cancer with Para-Aortic Lymph Node Metastases Successfully Treated with S-1/Docetaxel Chemotherapy].
Gan to kagaku ryoho. Cancer & chemotherapy.
2020 Mar; 47(3):548-550. doi:
NULL. [PMID: 32381945] - Keiji Nishibeppu, Shuhei Komatsu, Taisuke Imamura, Jun Kiuchi, Takuma Kishimoto, Tomohiro Arita, Toshiyuki Kosuga, Hirotaka Konishi, Takeshi Kubota, Atsushi Shiozaki, Hitoshi Fujiwara, Kazuma Okamoto, Eigo Otsuji. Plasma microRNA profiles: identification of miR-1229-3p as a novel chemoresistant and prognostic biomarker in gastric cancer.
Scientific reports.
2020 02; 10(1):3161. doi:
10.1038/s41598-020-59939-8. [PMID: 32081926] - Chia-Hsun Hsieh, Chien-Yu Lin, Cheng-Lung Hsu, Kang-Hsing Fan, Shiang-Fu Huang, Chun-Ta Liao, Li-Yu Lee, Shu-Kung Ng, Tzu-Chen Yen, Joseph Tung-Chieh Chang, Jr-Rung Lin, Hung-Ming Wang. Incorporation of Astragalus polysaccharides injection during concurrent chemoradiotherapy in advanced pharyngeal or laryngeal squamous cell carcinoma: preliminary experience of a phase II double-blind, randomized trial.
Journal of cancer research and clinical oncology.
2020 Jan; 146(1):33-41. doi:
10.1007/s00432-019-03033-8. [PMID: 31728618] - Ritsuko Shiokawa, Xiao-Pen Lee, Miho Yamada, Masaya Fujishiro, Hiroshi Sakamaki, Chika Hasegawa, Hiroo Ishida, Kenichiro Ikeda, Ken-Ichi Fujita, Shigehiro Iwabuchi, Hidetoshi Onda, Takeshi Kumazawa, Yasutsuna Sasaki, Keizo Sato, Takaaki Matsuyama. High-throughput method to analyze tegafur and 5-fluorouracil in human tears and plasma using hydrophilic interaction liquid chromatography/tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2019 Dec; 33(24):1906-1914. doi:
10.1002/rcm.8531. [PMID: 31323696] - Tsuyoshi Hasegawa, Hitoshi Teraoka, Takuya Mori, Haruhito Kinoshita, Kentaro Nakamoto, Eiji Noda, Kosei Hirakawa, Masaichi Ohira. [Analysis of Renal Toxicity of S-1 plus CDDP Regimen with Short Hydration for Outpatients with Gastric Cancer].
Gan to kagaku ryoho. Cancer & chemotherapy.
2019 Dec; 46(13):2407-2409. doi:
NULL. [PMID: 32156947] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Akimitsu Iizuka, Mitsuro Kanda, Seiji Ito, Yoshinari Mochizuki, Hitoshi Teramoto, Kiyoshi Ishigure, Toshifumi Murai, Takahiro Asada, Akiharu Ishiyama, Hidenobu Matsushita, Chie Tanaka, Daisuke Kobayashi, Michitaka Fujiwara, Kenta Murotani, Yasuhiro Kodera. Proposal of a Scoring Scale to Estimate Risk of the Discontinuation of S-1 Adjuvant Monotherapy in Patients with Stage II to III Gastric Cancer: A Multi-Institutional Dataset Analysis.
World journal of surgery.
2019 08; 43(8):2016-2024. doi:
10.1007/s00268-019-04942-y. [PMID: 30737551] - Lixia Yuan, Min Liu, Yabo Shi, Hui Yan, Jun Han, Liying Liu. Effect of (-)-epicatechin-3-gallate and (-)-epigallocatechin-3-gallate on the binding of tegafur to human serum albumin as determined by spectroscopy, isothermal titration calorimetry, and molecular docking.
Journal of biomolecular structure & dynamics.
2019 Jul; 37(11):2776-2788. doi:
10.1080/07391102.2018.1505550. [PMID: 30101645] - Hirofumi Yasui, Takeshi Kawakami, Hiroya Kashiwagi, Keita Mori, Katsuhiro Omae, Jun Kasai, Kunihiro Yoshisue, Masahiro Kawahira, Takahiro Tsushima, Nozomu Machida, Akira Fukutomi, Ken Yamaguchi. Pharmacokinetics of S-1 monotherapy in plasma and in tears for gastric cancer patients.
International journal of clinical oncology.
2019 Jun; 24(6):660-665. doi:
10.1007/s10147-018-01387-6. [PMID: 31011915] - Jun-Bao Liu, Tunyu Jian, Chao Yue, Dan Chen, Wei Chen, Ting-Ting Bao, Hai-Xia Liu, Yun Cao, Wei-Bing Li, Zhijian Yang, Robert M Hoffman, Chen Yu. Chemo-resistant Gastric Cancer Associated Gene Expression Signature: Bioinformatics Analysis Based on Gene Expression Omnibus.
Anticancer research.
2019 Apr; 39(4):1689-1698. doi:
10.21873/anticanres.13274. [PMID: 30952707] - Diemian Liang, Bo Yang. Short-term efficacy of oral low-dose Tegafur chemotherapy after transarterial chemoembolization in primary hepatic carcinoma.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology.
2019 Jan; 24(1):171-177. doi:
NULL. [PMID: 30941967] - Hae Won Lee, Sook Jin Seong, Woo Youl Kang, Boram Ohk, Mi-Ri Gwon, Bo Kyung Kim, Seungil Cho, Kyunghee Cho, Yong Kyung Sung, Young-Ran Yoon, Jong Gwang Kim. Pharmacokinetic and bioequivalence study between two formulations of S-1 in Korean gastric cancer patients.
Drug design, development and therapy.
2019; 13(?):3127-3136. doi:
10.2147/dddt.s219822. [PMID: 31564829] - Shinji Kobuchi, Yukako Ito, Daiki Takamatsu, Toshiyuki Sakaeda. Circadian variations in the pharmacokinetics of the oral anticancer agent tegafur-uracil (UFT) and its metabolites in rats.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2018 Oct; 123(?):452-458. doi:
10.1016/j.ejps.2018.08.004. [PMID: 30077713] - Yuichi Watanabe. [Renal Cancer after Spontaneous Rupture Successfully Treated with Low-Dose Oral UFT - A Case Report].
Gan to kagaku ryoho. Cancer & chemotherapy.
2018 Jul; 45(7):1117-1119. doi:
NULL. [PMID: 30042285] - Yoko Akune, Masakazu Yamada, Chika Shigeyasu. Determination of 5-fluorouracil and tegafur in tear fluid of patients treated with oral fluoropyrimidine anticancer agent, S-1.
Japanese journal of ophthalmology.
2018 Jul; 62(4):432-437. doi:
10.1007/s10384-018-0603-8. [PMID: 29931401] - Dejun Zhao, Jun-Fei Feng, Xue-Hui Wang. A retrospective study of concurrent radiotherapy plus S-1 for treating advanced non-small cell lung cancer.
Medicine.
2018 Jun; 97(22):e10740. doi:
10.1097/md.0000000000010740. [PMID: 29851779] - Yaolin Xu, Xi Guo, Yue Fan, Dansong Wang, Wenchuan Wu, Lili Wu, Tianshu Liu, Bei Xu, Yi Feng, Yan Wang, Wenhui Lou, Yuhong Zhou. Efficacy and safety comparison of nabpaclitaxel plus S-1 and gemcitabine plus S-1 as first-line chemotherapy for metastatic pancreatic cancer.
Japanese journal of clinical oncology.
2018 Jun; 48(6):535-541. doi:
10.1093/jjco/hyy063. [PMID: 29718363] - Kei Saito, Hiroyuki Isayama, Yoshihiro Sakamoto, Yousuke Nakai, Kazunaga Ishigaki, Mariko Tanaka, Takeyuki Watadani, Junichi Arita, Naminatsu Takahara, Suguru Mizuno, Hirofumi Kogure, Hideaki Ijichi, Keisuke Tateishi, Minoru Tada, Kiyoshi Hasegawa, Masashi Fukayama, Norihiro Kokudo, Kazuhiko Koike. A phase II trial of gemcitabine, S-1 and LV combination (GSL) neoadjuvant chemotherapy for patients with borderline resectable and locally advanced pancreatic cancer.
Medical oncology (Northwood, London, England).
2018 May; 35(7):100. doi:
10.1007/s12032-018-1158-8. [PMID: 29846849] - Naohiro Okano, Akiyoshi Kasuga, Kirio Kawai, Yoshiya Yamauchi, Takaaki Kobayashi, Daisuke Naruge, Fumio Nagashima, Junji Furuse. The Modified Glasgow Prognostic Score in Patients with Gemcitabine-refractory Biliary Tract Cancer.
Anticancer research.
2018 03; 38(3):1755-1761. doi:
10.21873/anticanres.12412. [PMID: 29491113] - Namju Kim, Jin Won Kim, Je-Hyun Baek, Jin-Soo Kim, Ho-Kyung Choung, Tae-Yong Kim, Kyung-Hun Lee, Yung-Jue Bang, Sang In Khwarg, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim, Jae-Yong Chung, Soyeon Ahn, Keun-Wook Lee. S-1-Induced Lacrimal Drainage Obstruction and Its Association with Ingredients/Metabolites of S-1 in Tears and Plasma: A Prospective Multi-institutional Study.
Cancer research and treatment.
2018 Jan; 50(1):30-39. doi:
10.4143/crt.2016.569. [PMID: 28253565] - Yuji Miura, Yasutaka Sukawa, Shuichi Hironaka, Misuzu Mori, Kazuhiro Nishikawa, Shinya Tokunaga, Hiroyuki Okuda, Takeshi Sakamoto, Keisei Taku, Kazuo Nishikawa, Toshikazu Moriwaki, Yuji Negoro, Yutaka Kimura, Keita Uchino, Katsunori Shinozaki, Hiroharu Shinozaki, Nobuyuki Musha, Hirotsugu Yoshiyama, Takashi Tsuda, Yoshinori Miyata, Naotoshi Sugimoto, Tsuyoshi Shirakawa, Miki Ito, Kimio Yonesaka, Kenichi Yoshimura, Narikazu Boku, Katsuhiko Nosho, Toshimi Takano, Ichinosuke Hyodo. Five-weekly S-1 plus cisplatin therapy combined with trastuzumab therapy in HER2-positive gastric cancer: a phase II trial and biomarker study (WJOG7212G).
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association.
2018 Jan; 21(1):84-95. doi:
10.1007/s10120-017-0725-6. [PMID: 28497176] - Tae Hwan Kim, Soyoung Shin, Jeong Cheol Shin, Jürgen B Bulitta, Kwon-Yeon Weon, Sun Dong Yoo, Gi-Young Park, Seok Won Jeong, Dong Rak Kwon, Byung Sun Min, Mi Hee Woo, Beom Soo Shin. Effect of Sipjeondaebo-Tang on the Pharmacokinetics of S-1, an Anticancer Agent, in Rats Evaluated by Population Pharmacokinetic Modeling.
Molecules (Basel, Switzerland).
2017 Sep; 22(9):. doi:
10.3390/molecules22091488. [PMID: 28880240] - Dae-Won Lee, Seock-Ah Im, Yu Jung Kim, Yaewon Yang, Jiyoung Rhee, Im Il Na, Kyung-Hun Lee, Tae-Yong Kim, Sae-Won Han, In Sil Choi, Do-Youn Oh, Jee Hyun Kim, Tae-You Kim, Yung-Jue Bang. CA19-9 or CEA Decline after the First Cycle of Treatment Predicts Survival in Advanced Biliary Tract Cancer Patients Treated with S-1 and Cisplatin Chemotherapy.
Cancer research and treatment.
2017 Jul; 49(3):807-815. doi:
10.4143/crt.2016.326. [PMID: 28111425] - Marta Broto, Rita McCabe, Roger Galve, M-Pilar Marco. A high throughput immunoassay for the therapeutic drug monitoring of tegafur.
The Analyst.
2017 Jun; 142(13):2404-2410. doi:
10.1039/c7an00418d. [PMID: 28555688] - Caspar Franck, Peter Malfertheiner, Marino Venerito. Safe administration of S-1 after 5-fluorouracil-induced cardiotoxicity in a patient with colorectal cancer.
BMJ case reports.
2017 May; 2017(?):. doi:
10.1136/bcr-2016-219162. [PMID: 28536214] - Tomoko Yamazaki, Makoto Tahara, Tomohiro Enokida, Tetsuro Wakasugi, Satoko Arahira, Sadamoto Zenda, Atsushi Motegi, Tetsuo Akimoto, Kunihiro Yoshisue. Pharmacokinetics of initial full and subsequent reduced doses of S-1 in patients with locally advanced head and neck cancer-effect of renal insufficiency.
Japanese journal of clinical oncology.
2017 May; 47(5):407-412. doi:
10.1093/jjco/hyx006. [PMID: 28159957] - Kei Sato, Hirotoshi Akiyama, Yuu Kogure, Yusuke Suwa, Masashi Momiyama, Atsushi Ishibe, Itaru Endo. [A Case of Rhabdomyolysis Related to SOX Therapy for Liver Metastasis of Gastric Cancer].
Gan to kagaku ryoho. Cancer & chemotherapy.
2017 Apr; 44(4):329-331. doi:
NULL. [PMID: 28428515] - Yoshiaki Murakami, Kenichiro Uemura, Takeshi Sudo, Yasushi Hashimoto, Naru Kondo, Naoya Nakagawa, Kenjiro Okada, Shinya Takahashi, Taijiro Sueda. Prognostic impact of normalization of serum tumor markers following neoadjuvant chemotherapy in patients with borderline resectable pancreatic carcinoma with arterial contact.
Cancer chemotherapy and pharmacology.
2017 04; 79(4):801-811. doi:
10.1007/s00280-017-3281-1. [PMID: 28314992] - Munehisa Takata, Isao Matsumoto, Yusuke Tanaka, Daisuke Saito, Shuhei Yoshida, Seiichi Kakegawa, Masaya Tamura, Hirofumi Takemura, Hiroko Ikeda. [A Recurrent Case of Thymic Adenocarcinoma Effectively Treated with S-1 Over a Long-Term Period].
Gan to kagaku ryoho. Cancer & chemotherapy.
2017 Mar; 44(3):239-242. doi:
NULL. [PMID: 28292994] - Kenji Usui, Takaaki Hanyu, Hiroshi Ichikawa, Takashi Ishikawa, Yusuke Muneoka, Yu Sato, Yosuke Kano, Takahiro Otani, Mariko Hishiki, Masayuki Nagahashi, Jun Sakata, Takashi Kobayashi, Hitoshi Kameyama, Shinichi Kosugi, Toshifumi Wakai. [A Case of Advanced Gastric Cancer with Portosystemic Shunt Successfully Treated with Percutaneous Transvenous Coil Embolization].
Gan to kagaku ryoho. Cancer & chemotherapy.
2016 Nov; 43(12):1917-1919. doi:
NULL. [PMID: 28133175] - Yukie Kyakumoto, Masamichi Mizuma, Tomoya Abe, Tatsuyuki Takadate, Koji Fukase, Hideo Otsuka, Naoaki Sakata, Kei Nakagawa, Takanori Morikawa, Hiroki Hayashi, Takeshi Naitoh, Fuyuhiko Motoi, Atsushi Kanno, Tooru Shimosegawa, Michiaki Unno. [A Case of Successful Stomach-Preserving Pancreaticoduodenectomy with Celiac Artery Resection after Neoadjuvant Chemoradiation Therapy for Pancreatic Cancer with Hepatic Arterial Variation].
Gan to kagaku ryoho. Cancer & chemotherapy.
2016 Nov; 43(12):1966-1968. doi:
NULL. [PMID: 28133191] - Kazuhiro Nishikawa, Chu Matsuda, Junji Kawada, Kazumasa Fujitani, Shunji Endo, Motohiro Hirao, Kazuyoshi Yamamoto, Sakae Maeda, Mamoru Uemura, Masakazu Miyake, Naoki Hama, Atsushi Miyamoto, Masataka Ikeda, Shoji Nakamori, Mitsugu Sekimoto. [A Case of Rectal Metastasis of Gastric Cancer Associated with Dermatomyositis].
Gan to kagaku ryoho. Cancer & chemotherapy.
2016 Nov; 43(12):2401-2403. doi:
. [PMID: 28133335] - Toru Aoyama, Masaaki Murakawa, Yosuke Atsumi, Keisuke Kazama, Manabu Shiozawa, Satoshi Kobayashi, Makoto Ueno, Manabu Morimoto, Kouta Washimi, Norio Yukawa, Yasushi Rino, Munetaka Masuda, Soichiro Morinaga. [A Case of Pancreatic Cancer Associated with Autoimmune Pancreatitis].
Gan to kagaku ryoho. Cancer & chemotherapy.
2016 Oct; 43(10):1289-1291. doi:
NULL. [PMID: 27760963] - Eriko Aotani, Tetsutaro Hamano, Akihiko Gemma, Masahiro Takeuchi, Toru Takebayashi, Kunihiko Kobayashi. Identification of adverse events that have a negative impact on quality of life in a clinical trial comparing docetaxel versus S-1 with cisplatin in lung cancer.
International journal of clinical oncology.
2016 Oct; 21(5):836-842. doi:
10.1007/s10147-016-0960-6. [PMID: 26879651] - Junfei Feng, Jinquan Xu, Xuehui Wang, Dejun Zhao. S-1 plus cisplatin with concurrent radiotherapy versus cisplatin alone with concurrent radiotherapy in Chinese patients with nonsmall-cell lung cancer: A multicentre randomized controlled trial.
Medicine.
2016 Sep; 95(36):e4557. doi:
10.1097/md.0000000000004557. [PMID: 27603346] - Misato Amaki, Kazuhito Yajima, Yoshiaki Iwasaki, Yuu Ken, Ryouki Oohinata, Akifumi Imamura. [Administration of S-1 Monotherapy as Adjuvant Chemotherapy in a Patient with Advanced Gastric Cancer with HIV Infection].
Gan to kagaku ryoho. Cancer & chemotherapy.
2016 Aug; 43(8):995-7. doi:
NULL. [PMID: 27539043] - Eisuke Booka, Chiyo K Imamura, Hiroya Takeuchi, Yasuo Hamamoto, Daisuke Gomi, Takuro Mizukami, Takashi Ichiyama, Kazunari Tateishi, Tsunehiro Takahashi, Hirofumi Kawakubo, Kenzo Soejima, Narikazu Boku, Yusuke Tanigawara, Yuko Kitagawa. Development of an S-1 dosage formula based on renal function by a prospective pharmacokinetic study.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association.
2016 Jul; 19(3):876-86. doi:
10.1007/s10120-015-0536-6. [PMID: 26304171] - Feng Xie, Jia-Ke Chai, Quan Hu, Yong-Hui Yu, Li Ma, Ling-Ying Liu, Xu-Long Zhang, Bai-Ling Li, Dong-Hai Zhang. Transdermal permeation of drugs with differing lipophilicity: Effect of penetration enhancer camphor.
International journal of pharmaceutics.
2016 Jun; 507(1-2):90-101. doi:
10.1016/j.ijpharm.2016.05.004. [PMID: 27154251] - Paula Mattos Dos Santos, Andrew J Hall, Panagiotis Manesiotis. Stoichiometric molecularly imprinted polymers for the recognition of anti-cancer pro-drug tegafur.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 May; 1021(?):197-203. doi:
10.1016/j.jchromb.2015.12.015. [PMID: 26711233] - Kohei Yamauchi, Toshio Kokuryo, Yukihiro Yokoyama, Keisuke Uehara, Junpei Yamaguchi, Masato Nagino. Prediction of Early Recurrence After Curative Resection of Colorectal Liver Metastasis and Subsequent S-1 Chemotherapy.
Anticancer research.
2016 May; 36(5):2175-9. doi:
. [PMID: 27127120] - Khurum Khan, David Cunningham, Clare Peckitt, Sarah Barton, Diana Tait, Maria Hawkins, David Watkins, Naureen Starling, Sheela Rao, Ruwaida Begum, Janet Thomas, Jacqui Oates, Vincenza Guzzardo, Matteo Fassan, Chiara Braconi, Ian Chau. miR-21 expression and clinical outcome in locally advanced pancreatic cancer: exploratory analysis of the pancreatic cancer Erbitux, radiotherapy and UFT (PERU) trial.
Oncotarget.
2016 Mar; 7(11):12672-81. doi:
10.18632/oncotarget.7208. [PMID: 26862857] - Hideomi Yamashita, Akihiro Haga, Ryousuke Takenaka, Tomoki Kiritoshi, Kae Okuma, Kuni Ohtomo, Keiichi Nakagawa. Efficacy and feasibility of ambulatory treatment-based monthly nedaplatin plus S-1 in definitive or salvage concurrent chemoradiotherapy for early, advanced, and relapsed esophageal cancer.
Radiation oncology (London, England).
2016 Jan; 11(?):4. doi:
10.1186/s13014-016-0587-9. [PMID: 26781439] - Hiroaki Nozawa, Soichiro Ishihara, Kazushige Kawai, Koji Murono, Koji Yasuda, Kensuke Otani, Takeshi Nishikawa, Toshiaki Tanaka, Tomomichi Kiyomatsu, Keisuke Hata, Toshiaki Watanabe. Paradoxical Reductions in Serum Anti-p53 Autoantibody Levels by Chemotherapy in Unresectable Colorectal Cancer: An Observational Study.
Oncology.
2016; 91(3):127-34. doi:
10.1159/000447241. [PMID: 27362767] - Kanako Shibata, Yoshinari Yasuda, Ryo Kobayashi, Yuichi Ando, Tomoya Shimokata, Hideki Kamiya, Mutsuharu Hayashi, Shoichi Maruyama, Seiichi Matsuo, Makoto Nakao, Teruo Tsuchiya, Hitomi Teramachi. Renal function evaluation in patients with cancer who were scheduled to receive carboplatin or S-1.
Clinical and experimental nephrology.
2015 Dec; 19(6):1107-13. doi:
10.1007/s10157-015-1115-1. [PMID: 25894220] - Kazuhiro Saso, Masaru Murata, Kensuke Asai, Moyuru Yamada, Tomoko Yagi, Shinsuke Katsuyama, Hirokazu Sawami, Hidekazu Takahashi, Osamu Takayama, Nobuo Tanaka, Masashi Baba, Masayuki Yamamoto, Masahiro Hiratsuka. [A Case of Pancreatic Cancer with Multiple Liver Metastases That Developed Postoperatively and Showed a Complete Response with S-1 Monotherapy].
Gan to kagaku ryoho. Cancer & chemotherapy.
2015 Nov; 42(12):1620-2. doi:
NULL. [PMID: 26805116] - Yutaka Kimura, Ken Ebihara, Fumitaka Kato, Yoichi Makari, Johta Mikami, Tomono Kawase, Takuya Hamakawa, Yuki Tsukamoto, Masaki Fujimori, Aya Gobaru, Daichi Mitsudo, Takamasa Yabuta, Ken Nakata, Masaki Tsujie, Shinji Kitamura, Hiroki Ohzato. [A Case of Rectal Stenosis For Gastric Cancer Recurrence Effectively Treated with a Colonic Stent].
Gan to kagaku ryoho. Cancer & chemotherapy.
2015 Nov; 42(12):1689-91. doi:
NULL. [PMID: 26805139] - Shuichi Aoki, Masamichi Mizuma, Motoki Oyauchi, Hiroshi Yoshida, Ryo Okada, Tomoya Abe, Naoaki Sakata, Kei Nakagawa, Hiroki Hayashi, Takanori Morikawa, Fuyuhiko Motoi, Takeshi Naitoh, Yoshinori Okada, Michiaki Unno. [A Patient with Three-Year Relapse-Free Survival after Surgical Resection for Lung and Liver Metastases of Cholangiocarcinoma].
Gan to kagaku ryoho. Cancer & chemotherapy.
2015 Nov; 42(12):1573-5. doi:
NULL. [PMID: 26805100] - Hiroyuki Saito, Yuki Suematsu, Miyuki Hiratsuka, Hiroshi Suda, Miyuki Takahashi, Keita Omori, Yuji Ishibashi, Akihiko Morita, Kazuhiko Wakabayashi, Yutaka Ito. [A Case of Advanced Gastric Cancer with Peritoneal Dissemination Effectively Treated with S-1 and Docetaxel Combination Chemotherapy].
Gan to kagaku ryoho. Cancer & chemotherapy.
2015 Nov; 42(12):2052-4. doi:
NULL. [PMID: 26805261] - Jinsei Miyoshi, Hiroshi Miyamoto, Takahiro Goji, Tatsuya Taniguchi, Tetsu Tomonari, Masahiro Sogabe, Tetsuo Kimura, Shinji Kitamura, Koichi Okamoto, Yasuteru Fujino, Naoki Muguruma, Toshiya Okahisa, Tetsuji Takayama. Serum diamine oxidase activity as a predictor of gastrointestinal toxicity and malnutrition due to anticancer drugs.
Journal of gastroenterology and hepatology.
2015 Nov; 30(11):1582-90. doi:
10.1111/jgh.13004. [PMID: 25968084] - K Yamashita, H Ushiku, N Katada, K Hosoda, H Moriya, H Mieno, S Kikuchi, K Hoshi, M Watanabe. Reduced preoperative serum albumin and absence of peritoneal dissemination may be predictive factors for long-term survival with advanced gastric cancer with positive cytology test.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.
2015 Oct; 41(10):1324-32. doi:
10.1016/j.ejso.2015.05.021. [PMID: 26251341] - Hayahito Nomi, Kiyoshi Takahara, Koichiro Minami, Ryoichi Maenosono, Tomohisa Matsunaga, Yuki Yoshikawa, Takuya Tsujino, Hajime Hirano, Teruo Inamoto, Ikuhisa Yamamoto, Motomu Tsuji, Satoshi Kiyama, Haruhito Azuma. [A CASE OF ADVANCED BLADDER NEUROENDOCRINE CARCINOMA (SMALL CELL CARCINOMA) SIGNIFICANTLY IMPROVED BY LOW DOSE OF ORAL TEGAFUR-URACIL].
Nihon Hinyokika Gakkai zasshi. The japanese journal of urology.
2015 Oct; 106(4):269-73. doi:
10.5980/jpnjurol.106.269. [PMID: 26717786] - S Naito, H Sakai, K Hashine, Y Tomita, N Shinohara, M Fujisawa, M Eto, S Ozono, H Akaza. Phase I/II study of S-1 in combination with sorafenib for metastatic renal cell carcinoma.
Annals of oncology : official journal of the European Society for Medical Oncology.
2015 Sep; 26(9):1871-1876. doi:
10.1093/annonc/mdv280. [PMID: 26117830] - Judith R Kroep, Erik van Werkhoven, Marco Polee, Cees J van Groeningen, Aart Beeker, Frans Erdkamp, Nir Weijl, Aart van Bochove, Zoran Erjavec, Ellen Kapiteijn, Anne M Stiggelbout, Hans W R Nortier, Hans Gelderblom. Randomised study of tegafur-uracil plus leucovorin versus capecitabine as first-line therapy in elderly patients with advanced colorectal cancer--TLC study.
Journal of geriatric oncology.
2015 Jul; 6(4):307-15. doi:
10.1016/j.jgo.2015.05.004. [PMID: 26073532] - H Yamaguchi, J Kitayama, S Emoto, H Ishigami, T Ito, N Hanafusa, T Watanabe. Cell-free and concentrated ascites reinfusion therapy (CART) for management of massive malignant ascites in gastric cancer patients with peritoneal metastasis treated with intravenous and intraperitoneal paclitaxel with oral S-1.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.
2015 Jul; 41(7):875-80. doi:
10.1016/j.ejso.2015.04.013. [PMID: 25986856] - Takatsugu Yamamoto, Toru Miyazaki, Yukiko Kurashima, Kazunori Ohata, Masato Okawa, Shogo Tanaka, Takahiro Uenishi, Koichi Ohno. [A Case Report of Successful Chemotherapy with Tegafur/Gimeracil/Oteracil and Nab-Paclitaxel for Gastric Cancer with Chronic Renal Failure].
Gan to kagaku ryoho. Cancer & chemotherapy.
2015 Jun; 42(6):735-8. doi:
. [PMID: 26199247] - Kazuhiro Nishikawa, Kazumasa Fujitani, Hitoshi Inagaki, Yusuke Akamaru, Shinya Tokunaga, Masakazu Takagi, Shigeyuki Tamura, Naotoshi Sugimoto, Tadashi Shigematsu, Takaki Yoshikawa, Tohru Ishiguro, Masato Nakamura, Satoshi Morita, Yumi Miyashita, Akira Tsuburaya, Junichi Sakamoto, Toshimasa Tsujinaka. Randomised phase III trial of second-line irinotecan plus cisplatin versus irinotecan alone in patients with advanced gastric cancer refractory to S-1 monotherapy: TRICS trial.
European journal of cancer (Oxford, England : 1990).
2015 May; 51(7):808-16. doi:
10.1016/j.ejca.2015.02.009. [PMID: 25797356] - Shoji Kimura, Shin-Ichiro Kira, Haruhisa Koide, Kan Suzuki, Jun Moritake, Yukiko Hiramoto, Masayuki Tomita, Hiroshi Kiyota, Shin Egawa, Mamoru Ishiyama, Kazuhiko Yoshida, Akihiko Sakata. [Vesico-appendiceal fistula caused by appendiceal cancer: a case report].
Hinyokika kiyo. Acta urologica Japonica.
2015 Mar; 61(3):95-8. doi:
NULL. [PMID: 25918266] - Akiyoshi Kasuga, Naohiro Okano, Daisuke Naruge, Hiroshi Kitamura, Atsuko Takasu, Fumio Nagashima, Junji Furuse. Retrospective analysis of fixed dose rate infusion of gemcitabine and S-1 combination therapy (FGS) as salvage chemotherapy in patients with gemcitabine-refractory advanced pancreatic cancer: inflammation-based prognostic score predicts survival.
Cancer chemotherapy and pharmacology.
2015 Mar; 75(3):457-64. doi:
10.1007/s00280-014-2665-8. [PMID: 25547407] - Hiroki Izumi, Hirokazu Touge, Tadashi Igishi, Haruhiko Makino, Shizuka Nishii-Ito, Miyako Takata, Hirofumi Nakazaki, Yasuto Ueda, Shingo Matsumoto, Masahiro Kodani, Jun Kurai, Kenichi Takeda, Tomohiro Sakamoto, Masaaki Yanai, Natsumi Tanaka, Chaitanya S Nirodi, Eiji Shimizu. Favorable effect of the combination of vinorelbine and dihydropyrimidine dehydrogenase‑inhibitory fluoropyrimidine in EGFR‑mutated lung adenocarcinoma: retrospective and in vitro studies.
International journal of oncology.
2015 Mar; 46(3):989-98. doi:
10.3892/ijo.2015.2815. [PMID: 25573239] - Toshihiro Komura, Koh Miura, Tetsuhiko Shirasaka, Shinobu Ohnuma, Miki Shimada, Taiki Kajiwara, Fumiyoshi Fujishima, Alex Philchenkov, Kei Nakagawa, Katsuyoshi Kudoh, Sho Haneda, Masahide Toshima, Atsushi Kohyama, Hiroaki Musha, Takeshi Naitoh, Chikashi Shibata, Michiaki Unno. Usefulness of alternate-day administration of S-1 and leucovorin in a xenograft mouse model of colorectal cancer: a shorter drug-free interval leads to more efficient antitumor effects.
International journal of clinical oncology.
2015 Feb; 20(1):117-25. doi:
10.1007/s10147-014-0699-x. [PMID: 24802097] - Shigetomi Nakao, Bunzo Nakata, Masashige Tendo, Kenji Kuroda, Takeshi Hori, Mayumi Inaba, Kosei Hirakawa, Tetsuro Ishikawa. Salvage surgery after chemotherapy with S-1 plus cisplatin for α-fetoprotein-producing gastric cancer with a portal vein tumor thrombus: a case report.
BMC surgery.
2015 Jan; 15(?):5. doi:
10.1186/1471-2482-15-5. [PMID: 25591731] - Toshinori Sueda, Toshihiro Kudo, Daisuke Sakai, Mamoru Uemura, Junichi Nishimura, Taishi Hata, Ichiro Takemasa, Tsunekazu Mizushima, Hirofumi Yamamoto, Sachiko Ezoe, Kana Matsumoto, Yuichiro Doki, Masaki Mori, Taroh Satoh. Safety and pharmacokinetics of S-1 in a recurrent colon cancer patient with chronic myeloid leukemia treated with dasatinib: a case report.
Cancer chemotherapy and pharmacology.
2014 Dec; 74(6):1321-4. doi:
10.1007/s00280-014-2620-8. [PMID: 25374410] - Toru Aoyama, Yusuke Katayama, Masaaki Murakawa, Masahiro Asari, Amane Kanazawa, Akio Higuchi, Manabu Shiozawa, Satoshi Kobayashi, Makoto Ueno, Manabu Morimoto, Shinnichi Ohkawa, Makoto Akaike, Naoto Yamamoto, Takaki Yoshikawa, Yasushi Rino, Munetaka Masuda, Soichiro Morinaga. Risk factors for 6-month continuation of S-1 adjuvant chemotherapy for resected pancreatic cancer.
Cancer chemotherapy and pharmacology.
2014 Dec; 74(6):1235-40. doi:
10.1007/s00280-014-2601-y. [PMID: 25297990] - Ikuo Yamamiya, Kunihiro Yoshisue, Yuji Ishii, Hideyuki Yamada, Ken-ichiro Yoshida. Species variation in the enantioselective metabolism of tegafur to 5-fluorouracil among rats, dogs and monkeys.
The Journal of pharmacy and pharmacology.
2014 Dec; 66(12):1686-97. doi:
10.1111/jphp.12304. [PMID: 25117829] - Yasuo Nagai, Takuya Kato, Masao Harano, Daisuke Satoh, Yasuhiro Choda, Noriaki Tokumoto, Takashi Kanazawa, Hiroyoshi Matsukawa, Yasutomo Ojima, Hitoshi Idani, Shigehiro Shiozaki, Masazumi Okajima, Motoki Ninomiya, Satoshi Ohno. [A case of AFP-producing esophagogastric junction cancer with liver metastases with a good response to chemotherapy].
Gan to kagaku ryoho. Cancer & chemotherapy.
2014 Nov; 41(12):2349-51. doi:
NULL. [PMID: 25731519] - Kazuyuki Okada, Chikara Ebisui, Yoichiro Nushijima, Tetsu Yanagisawa, Shu Okamura, Nariaki Fukuchi, Kohei Murata, Hideoki Yokouchi, Masakatsu Kinuta. [A case of successful treatment of peritoneal dissemination from gastric cancer with S-1/DOC chemotherapy].
Gan to kagaku ryoho. Cancer & chemotherapy.
2014 Nov; 41(12):2361-3. doi:
NULL. [PMID: 25731523] - Tohru Otsuru, Shohei Iijima, Naoto Tsujimura, Eiichirou Nakao, Takashi Matsumoto, Kou Takachi, Kiyonori Nishioka, Hiroyoshi Takemoto, Satoshi Oshima, Yoshio Uemura, Kyotaro Yoshida, Kenji Kobayashi. [A case of gastric cancer with multiple liver metastases that was successfully treated by chemotherapy].
Gan to kagaku ryoho. Cancer & chemotherapy.
2014 Nov; 41(12):2419-21. doi:
NULL. [PMID: 25731543] - Tsutomu Takashima, Takahiro Nakayama, Katsuhide Yoshidome, Hidemi Kawajiri, Shunji Kamigaki, Junji Tsurutani, Takashi Arai, Toshikazu Ito, Yoshihumi Komoike, Takako Doi, Norikazu Masuda, Keisuke Miyauchi, Yasuo Miyoshi, Junichi Sakamoto, Satoshi Morita, Tetsuya Taguchi. Phase II study of S-1 in combination with trastuzumab for HER2-positive metastatic breast cancer.
Anticancer research.
2014 Jul; 34(7):3583-8. doi:
NULL. [PMID: 24982373] - Jeeyun Lee, Sang Joon Shin, Ik Joo Chung, Tae Won Kim, Hoo-Geun Chun, Dong Bok Shin, Yeul Hong Kim, Hong Suk Song, Sae-Won Han, Jong Gwang Kim, Sun Young Kim, Young Jin Choi, Hyun Cheol Chung. A phase II open-label randomized multicenter trial of TSU-68 in combination with S-1 and oxaliplatin versus S-1 in combination with oxaliplatin in patients with metastatic colorectal cancer.
Investigational new drugs.
2014 Jun; 32(3):561-8. doi:
10.1007/s10637-014-0075-8. [PMID: 24573743] - Tomonori Iida, Yukio Nakabayashi, Norimitsu Okui, Hiroaki Shiba, Masahiko Otsuka, Katsuhiko Yanaga. Successful management of metachronous liver metastasis after pancreaticoduodectomy for pancreatic ductal carcinoma using hepatectomy and chemotherapy: a case report.
Anticancer research.
2014 May; 34(5):2417-20. doi:
NULL. [PMID: 24778053] - Hiroki Sumiyoshi, Akira Matsushita, Yoshiharu Nakamura, Kazuya Yamahatsu, Akira Katsuno, Eiji Uchida. [Radical resection of a locally advanced pancreatic tail adenosquamous carcinoma treated with S-1 and gemcitabine as neoadjuvant chemotherapy - a case report].
Gan to kagaku ryoho. Cancer & chemotherapy.
2014 May; 41(5):669-72. doi:
NULL. [PMID: 24917020] - Chih-Wen Twu, Wen-Yi Wang, Chien-Chih Chen, Kai-Li Liang, Rong-San Jiang, Ching-Te Wu, Yi-Ting Shih, Po-Ju Lin, Yi-Chun Liu, Jin-Ching Lin. Metronomic adjuvant chemotherapy improves treatment outcome in nasopharyngeal carcinoma patients with postradiation persistently detectable plasma Epstein-Barr virus deoxyribonucleic acid.
International journal of radiation oncology, biology, physics.
2014 May; 89(1):21-9. doi:
10.1016/j.ijrobp.2014.01.052. [PMID: 24725686] - Yasuhiro Suzuki, Rin Ogiya, Risa Oshitanai, Mayako Terao, Mizuho Terada, Toru Morioka, Banri Tsuda, Naoki Niikura, Takuho Okamura, Yuki Saito, Yutaka Tokuda. Feasibility and pharmacokinetics of combined therapy with S-1 and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic or recurrent breast cancer.
International journal of clinical oncology.
2014 Apr; 19(2):274-9. doi:
10.1007/s10147-013-0547-4. [PMID: 23558559] - Yasuyuki Yoshida, Kazuaki Yamanaka, Norichika Ueda, Toshiaki Hirai, Hidefumi Kishikawa, Kenji Nishimura, Yasuji Ichikawa. [A case of urachal carcinoma with multiple lung metastases treated by TS-1/CDDP chemotherapy].
Hinyokika kiyo. Acta urologica Japonica.
2014 Mar; 60(3):147-50. doi:
. [PMID: 24759503] - Seiji Naito, Katsunori Tatsugami, Nobuo Shinohara, Yoshihiko Tomita, Atsushi Mizokami, Masato Fujisawa, Katsuyoshi Hashine, Masaharu Nishikido, Masayuki Nakagawa, Taiji Tsukamoto, Hideyuki Akaza. Final results of a phase II study of S-1 in patients with cytokine-refractory metastatic renal cell carcinoma.
Japanese journal of clinical oncology.
2014 Feb; 44(2):122-6. doi:
10.1093/jjco/hyt185. [PMID: 24298041] - Wakako Tsuji, Hiroshi Ishiguro, Sunao Tanaka, Megumi Takeuchi, Takayuki Ueno, Masakazu Toi. Orally administered S-1 suppresses circulating endothelial cell counts in metastatic breast cancer patients.
International journal of clinical oncology.
2014; 19(3):452-9. doi:
10.1007/s10147-013-0570-5. [PMID: 23739924] - Natsuko Takahashi, Masaki Kobayashi, Jiro Ogura, Hiroaki Yamaguchi, Takashi Satoh, Kazuhiro Watanabe, Ken Iseki. Immunoprotective effect of epigallocatechin-3-gallate on oral anticancer drug-induced α-defensin reduction in Caco-2 cells.
Biological & pharmaceutical bulletin.
2014; 37(3):490-2. doi:
10.1248/bpb.b13-00700. [PMID: 24583869]
