7alpha-Hydroxycholesterol (BioDeep_00000003251)

Main id: BioDeep_00000636693

Secondary id: BioDeep_00000419054

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


(1S,2R,5S,9S,10S,11S,14R,15R)-2,15-dimethyl-14-[(2R)-6-methylheptan-2-yl]tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-ene-5,9-diol

化学式: C27H46O2 (402.3498)
中文名称: 胆甾-5-烯-3,7二醇
谱图信息: 最多检出来源 Homo sapiens(otcml) 25.7%

分子结构信息

SMILES: CC(C)CCCC(C)C1CCC2C1(CCC3C2C(C=C4C3(CCC(C4)O)C)O)C
InChI: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h16-18,20-25,28-29H,6-15H2,1-5H3/t18-,20+,21-,22+,23+,24-,25+,26+,27-/m1/s1

描述信息

7alpha-Hydroxycholesterol is an oxysterol and can serve as a biomarker for lipid peroxidation (PMID: 17386651). Products of cholesterol oxidation accumulate within atherosclerotic plaque and have been proposed to contribute to inflammatory signalling in the diseased artery (PMID: 17364953). 7alpha-Hydroxycholesterol is a cholesterol oxide that has been described as a biomarker of oxidative stress in subjects with impaired glucose tolerance and diabetes (PMID: 16634125). 7alpha-Hydroxycholesterol has been identified in the human placenta (PMID: 32033212).
7alpha-hydroxycholesterol is an oxysterol and can serve as a biomarker for lipid peroxidation. (PMID: 17386651) Products of cholesterol oxidation accumulate within atherosclerotic plaque and have been proposed to contribute to inflammatory signalling in the diseased artery. (PMID: 17364953)
7α-Hydroxycholesterol is a cholesterol oxide and is formed by both enzymatic and non-enzymatic oxidation. 7α-Hydroxycholesterol can be used as a biomarker for lipid peroxidation[1][2].

同义名列表

22 个代谢物同义名

(1S,2R,5S,9S,10S,11S,14R,15R)-2,15-dimethyl-14-[(2R)-6-methylheptan-2-yl]tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-ene-5,9-diol; (3beta,7alpha)-Cholest-5-ene-3,7-diol; 7alpha-Hydroxycholest-5-en-3beta-ol; Cholest-5-en-3 beta,7 alpha-diol; Cholest-5-ene-3beta,7alpha-diol; cholest-5-en-3beta,7alpha-diol; (3Β,7α)-cholest-5-ene-3,7-diol; 7Α-hydroxycholest-5-en-3β-ol; 7α-hydroxy-cholesterol; 7alpha-hydroxy-cholesterol; 7-beta-Hydroxy-Cholesterol; 7 alpha-Hydroxycholesterol; 7alpha-Hydroxycholesterol; Cholest-5-ene-3β,7α-diol; Cholest-5-ene-3b,7a-diol; 7a-Hydroxy-cholesterol; 7Α-hydroxy-cholesterol; 7α-hydroxycholesterol; 7a-Hydroxycholesterol; 7AlphaOHChol; 7ΑOHChol; 7alpha-Hydroxycholesterol



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(10)

BioCyc(0)

PlantCyc(0)

代谢反应

102 个相关的代谢反应过程信息。

Reactome(96)

BioCyc(1)

WikiPathways(3)

Plant Reactome(0)

INOH(2)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

5 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 AKT1, ALB, APOB, APOE, CASP3, MAPK14, MAPK8, NFE2L2, PIK3CA, SCP2
Peripheral membrane protein 1 CYP27A1
Endosome membrane 1 APOB
Endoplasmic reticulum membrane 3 ACAT1, APOB, CYP7B1
Mitochondrion membrane 1 CYP27A1
Nucleus 9 AKT1, ALB, APOE, CASP3, MAPK14, MAPK8, NFE2L2, RORA, SCP2
cytosol 9 AKT1, ALB, APOB, CASP3, MAPK14, MAPK8, NFE2L2, PIK3CA, SCP2
dendrite 1 APOE
centrosome 2 ALB, NFE2L2
nucleoplasm 7 AKT1, CASP3, MAPK14, MAPK8, NFE2L2, RORA, SCP2
RNA polymerase II transcription regulator complex 1 NFE2L2
Cell membrane 3 AKT1, TLR6, TNF
lamellipodium 2 AKT1, PIK3CA
Multi-pass membrane protein 2 ACAT1, CYP7B1
Synapse 1 MAPK8
cell cortex 1 AKT1
cell surface 1 TNF
glutamatergic synapse 4 AKT1, APOE, CASP3, MAPK14
Golgi apparatus 4 ALB, APOE, NFE2L2, TLR6
mitochondrial inner membrane 1 CYP27A1
neuronal cell body 4 APOB, APOE, CASP3, TNF
postsynapse 1 AKT1
smooth endoplasmic reticulum 1 APOB
Cytoplasm, cytosol 1 NFE2L2
plasma membrane 7 AKT1, APOB, APOE, NFE2L2, PIK3CA, TLR6, TNF
Membrane 7 ACAT1, AKT1, APOE, CYP7B1, LCAT, SCP2, TLR6
axon 1 MAPK8
extracellular exosome 5 ACAT1, ALB, APOB, APOE, LCAT
endoplasmic reticulum 4 ACAT1, ALB, APOE, SCP2
extracellular space 7 ALB, APOB, APOE, CCL2, CRP, LCAT, TNF
lysosomal lumen 1 APOB
perinuclear region of cytoplasm 1 PIK3CA
intercalated disc 1 PIK3CA
mitochondrion 4 ACAT1, CYP27A1, MAPK14, SCP2
protein-containing complex 3 AKT1, ALB, SCP2
intracellular membrane-bounded organelle 1 APOB
Microsome membrane 1 CYP7B1
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 TLR6
Secreted 6 ALB, APOB, APOE, CCL2, CRP, LCAT
extracellular region 8 ALB, APOB, APOE, CCL2, CRP, LCAT, MAPK14, TNF
mitochondrial matrix 2 ACAT1, CYP27A1
anchoring junction 1 ALB
external side of plasma membrane 1 TNF
Endosome, multivesicular body 1 APOE
Extracellular vesicle 1 APOE
Secreted, extracellular space, extracellular matrix 1 APOE
chylomicron 2 APOB, APOE
high-density lipoprotein particle 2 APOE, LCAT
low-density lipoprotein particle 2 APOB, APOE
multivesicular body 1 APOE
very-low-density lipoprotein particle 2 APOB, APOE
microtubule cytoskeleton 1 AKT1
nucleolus 1 RORA
Early endosome 2 APOB, APOE
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Mitochondrion inner membrane 1 CYP27A1
Membrane raft 2 TLR6, TNF
spindle 1 AKT1
extracellular matrix 1 APOE
Peroxisome 1 SCP2
peroxisomal matrix 1 SCP2
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 APOE
nuclear speck 1 MAPK14
receptor complex 1 TLR6
ciliary basal body 2 AKT1, ALB
chromatin 2 NFE2L2, RORA
mediator complex 1 NFE2L2
Cytoplasmic vesicle, phagosome membrane 1 TLR6
phagocytic cup 1 TNF
phagocytic vesicle membrane 1 TLR6
Chromosome 1 SCP2
centriole 1 ALB
Secreted, extracellular space 1 APOE
spindle pole 2 ALB, MAPK14
condensed chromosome, centromeric region 1 SCP2
blood microparticle 2 ALB, APOE
endosome lumen 1 APOB
Lipid droplet 1 APOB
lateral element 1 SCP2
Melanosome 1 APOE
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 1 MAPK14
endoplasmic reticulum lumen 3 ALB, APOB, APOE
platelet alpha granule lumen 1 ALB
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
endoplasmic reticulum exit site 1 APOB
clathrin-coated endocytic vesicle membrane 2 APOB, APOE
synaptic cleft 1 APOE
protein-DNA complex 1 NFE2L2
synaptonemal complex 1 SCP2
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
Toll-like receptor 2-Toll-like receptor 6 protein complex 1 TLR6
discoidal high-density lipoprotein particle 1 APOE
endocytic vesicle lumen 2 APOB, APOE
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
chylomicron remnant 2 APOB, APOE
intermediate-density lipoprotein particle 2 APOB, APOE
lipoprotein particle 1 APOE
multivesicular body, internal vesicle 1 APOE
mature chylomicron 1 APOB
[Isoform SCP2]: Peroxisome 1 SCP2
[Isoform SCPx]: Peroxisome 1 SCP2
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Imen Ghzaiel, Amira Zarrouk, Vivien Pires, Jean-Paul Pais de Barros, Sonia Hammami, Mohamed Ksila, Mohamed Hammami, Taoufik Ghrairi, Pierre Jouanny, Anne Vejux, Gérard Lizard. 7β-Hydroxycholesterol and 7-ketocholesterol: New oxidative stress biomarkers of sarcopenia inducing cytotoxic effects on myoblasts and myotubes. The Journal of steroid biochemistry and molecular biology. 2023 Jun; 232(?):106345. doi: 10.1016/j.jsbmb.2023.106345. [PMID: 37286110]
  • Leila Rezig, Imen Ghzaiel, Mohamed Ksila, Aline Yammine, Thomas Nury, Amira Zarrouk, Mohammad Samadi, Moncef Chouaibi, Anne Vejux, Gérard Lizard. Cytoprotective activities of representative nutrients from the Mediterranean diet and of Mediterranean oils against 7-ketocholesterol- and 7β-hydroxycholesterol-induced cytotoxicity: Application to age-related diseases and civilization diseases. Steroids. 2022 11; 187(?):109093. doi: 10.1016/j.steroids.2022.109093. [PMID: 36029811]
  • Imen Ghzaiel, Amira Zarrouk, Soukaina Essadek, Lucy Martine, Souha Hammouda, Aline Yammine, Mohamed Ksila, Thomas Nury, Wiem Meddeb, Mounia Tahri Joutey, Wafa Mihoubi, Claudio Caccia, Valerio Leoni, Mohammad Samadi, Niyazi Acar, Pierre Andreoletti, Sonia Hammami, Taoufik Ghrairi, Anne Vejux, Mohamed Hammami, Gérard Lizard. Protective effects of milk thistle (Sylibum marianum) seed oil and α-tocopherol against 7β-hydroxycholesterol-induced peroxisomal alterations in murine C2C12 myoblasts: Nutritional insights associated with the concept of pexotherapy. Steroids. 2022 07; 183(?):109032. doi: 10.1016/j.steroids.2022.109032. [PMID: 35381271]
  • T Nury, A Yammine, I Ghzaiel, K Sassi, A Zarrouk, F Brahmi, M Samadi, S Rup-Jacques, D Vervandier-Fasseur, J P Pais de Barros, V Bergas, S Ghosh, M Majeed, A Pande, A Atanasov, S Hammami, M Hammami, J Mackrill, B Nasser, P Andreoletti, M Cherkaoui-Malki, A Vejux, G Lizard. Attenuation of 7-ketocholesterol- and 7β-hydroxycholesterol-induced oxiapoptophagy by nutrients, synthetic molecules and oils: Potential for the prevention of age-related diseases. Ageing research reviews. 2021 07; 68(?):101324. doi: 10.1016/j.arr.2021.101324. [PMID: 33774195]
  • Souha Hammouda, Imen Ghzaiel, Pol Picón-Pagès, Wiem Meddeb, Wided Khamlaoui, Sonia Hammami, Francisco J Muñoz, Mohamed Hammami, Amira Zarrouk. Nigella and Milk Thistle Seed Oils: Potential Cytoprotective Effects against 7β-Hydroxycholesterol-Induced Toxicity on SH-SY5Y Cells. Biomolecules. 2021 05; 11(6):. doi: 10.3390/biom11060797. [PMID: 34071950]
  • Mason McComb, Richard W Browne, Sonia Bhattacharya, Mary Lou Bodziak, Dejan Jakimovski, Bianca Weinstock-Guttman, Jens Kuhle, Robert Zivadinov, Murali Ramanathan. The cholesterol autoxidation products, 7-ketocholesterol and 7β-hydroxycholesterol are associated with serum neurofilaments in multiple sclerosis. Multiple sclerosis and related disorders. 2021 May; 50(?):102864. doi: 10.1016/j.msard.2021.102864. [PMID: 33677412]
  • Anne Vejux, Dehbia Abed-Vieillard, Khadija Hajji, Amira Zarrouk, John J Mackrill, Shubhrima Ghosh, Thomas Nury, Aline Yammine, Mohamed Zaibi, Wafa Mihoubi, Habiba Bouchab, Boubker Nasser, Yaël Grosjean, Gérard Lizard. 7-Ketocholesterol and 7β-hydroxycholesterol: In vitro and animal models used to characterize their activities and to identify molecules preventing their toxicity. Biochemical pharmacology. 2020 03; 173(?):113648. doi: 10.1016/j.bcp.2019.113648. [PMID: 31586589]
  • Hiroshi Takahashi, Tatsuya Hoshino. A comparative study of the effects of 7β-hydroxycholesterol, 25-hydroxycholesterol, and cholesterol on the structural and thermal phase behavior of multilamellar dipalmitoylphosphatidylcholine bilayer vesicles. Chemistry and physics of lipids. 2020 03; 227(?):104872. doi: 10.1016/j.chemphyslip.2020.104872. [PMID: 31926857]
  • Thomas Nury, Aline Yammine, Franck Menetrier, Amira Zarrouk, Anne Vejux, Gérard Lizard. 7-Ketocholesterol- and 7β-Hydroxycholesterol-Induced Peroxisomal Disorders in Glial, Microglial and Neuronal Cells: Potential Role in Neurodegeneration : 7-ketocholesterol and 7β-hydroxycholesterol-Induced Peroxisomal Disorders and Neurodegeneration. Advances in experimental medicine and biology. 2020; 1299(?):31-41. doi: 10.1007/978-3-030-60204-8_3. [PMID: 33417205]
  • William J Griffiths, Eylan Yutuc, Jonas Abdel-Khalik, Peter J Crick, Thomas Hearn, Alison Dickson, Brian W Bigger, Teresa Hoi-Yee Wu, Anu Goenka, Arunabha Ghosh, Simon A Jones, Douglas F Covey, Daniel S Ory, Yuqin Wang. Metabolism of Non-Enzymatically Derived Oxysterols: Clues from sterol metabolic disorders. Free radical biology & medicine. 2019 11; 144(?):124-133. doi: 10.1016/j.freeradbiomed.2019.04.020. [PMID: 31009661]
  • Randa Sghaier, Thomas Nury, Valerio Leoni, Claudio Caccia, Jean-Paul Pais De Barros, Ameur Cherif, Anne Vejux, Thibault Moreau, Khalifa Limem, Mohammad Samadi, John J Mackrill, Ahmed Slaheddine Masmoudi, Gérard Lizard, Amira Zarrouk. Dimethyl fumarate and monomethyl fumarate attenuate oxidative stress and mitochondrial alterations leading to oxiapoptophagy in 158N murine oligodendrocytes treated with 7β-hydroxycholesterol. The Journal of steroid biochemistry and molecular biology. 2019 11; 194(?):105432. doi: 10.1016/j.jsbmb.2019.105432. [PMID: 31344443]
  • K Sassi, T Nury, A Zarrouk, R Sghaier, A Khalafi-Nezhad, A Vejux, M Samadi, F Ben Aissa-Fennira, G Lizard. Induction of a non-apoptotic mode of cell death associated with autophagic characteristics with steroidal maleic anhydrides and 7β-hydroxycholesterol on glioma cells. The Journal of steroid biochemistry and molecular biology. 2019 07; 191(?):105371. doi: 10.1016/j.jsbmb.2019.04.020. [PMID: 31034873]
  • B Šošić-Jurjević, D Lütjohann, K Renko, B Filipović, N Radulović, V Ajdžanović, S Trifunović, N Nestorović, J Živanović, M Manojlović Stojanoski, J Kӧhrle, V Milošević. The isoflavones genistein and daidzein increase hepatic concentration of thyroid hormones and affect cholesterol metabolism in middle-aged male rats. The Journal of steroid biochemistry and molecular biology. 2019 06; 190(?):1-10. doi: 10.1016/j.jsbmb.2019.03.009. [PMID: 30885834]
  • Randa Sghaier, Amira Zarrouk, Thomas Nury, Ilham Badreddine, Nora O'Brien, John J Mackrill, Anne Vejux, Mohammad Samadi, Boubker Nasser, Claudio Caccia, Valerio Leoni, Thibault Moreau, Mustapha Cherkaoui-Malki, Ahmed Salhedine Masmoudi, Gérard Lizard. Biotin attenuation of oxidative stress, mitochondrial dysfunction, lipid metabolism alteration and 7β-hydroxycholesterol-induced cell death in 158N murine oligodendrocytes. Free radical research. 2019 05; 53(5):535-561. doi: 10.1080/10715762.2019.1612891. [PMID: 31039616]
  • Amira Zarrouk, Mohammed Ali Smach, Jawhar Hafsa, Randa Sghaier, Hatem Majdoub, Mohammed Hammami, Bassem Charfeddine. Effects of Carpobrotus edulis Extract on Oxidative Stress and 158N Oligodendrocyte Death. Biomedical and environmental sciences : BES. 2019 Apr; 32(4):291-299. doi: 10.3967/bes2019.039. [PMID: 31217065]
  • Amira Zarrouk, Yosra Ben Salem, Jawhar Hafsa, Randa Sghaier, Bassem Charfeddine, Khalifa Limem, Mohamed Hammami, Hatem Majdoub. 7β-hydroxycholesterol-induced cell death, oxidative stress, and fatty acid metabolism dysfunctions attenuated with sea urchin egg oil. Biochimie. 2018 Oct; 153(?):210-219. doi: 10.1016/j.biochi.2018.06.027. [PMID: 30003930]
  • Yidan Sun, Susanne Kopp, Jasmin Strutz, Chaitanya Chakravarthi Gali, Martina Zandl-Lang, Elham Fanaee-Danesh, Andrijana Kirsch, Silvija Cvitic, Saša Frank, Richard Saffery, Ingemar Björkhem, Gernot Desoye, Christian Wadsack, Ute Panzenboeck. Gestational diabetes mellitus modulates cholesterol homeostasis in human fetoplacental endothelium. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2018 09; 1863(9):968-979. doi: 10.1016/j.bbalip.2018.05.005. [PMID: 29778664]
  • Monica Deiana, Simone Calfapietra, Alessandra Incani, Angela Atzeri, Daniela Rossin, Roberto Loi, Barbara Sottero, Noemi Iaia, Giuseppe Poli, Fiorella Biasi. Derangement of intestinal epithelial cell monolayer by dietary cholesterol oxidation products. Free radical biology & medicine. 2017 12; 113(?):539-550. doi: 10.1016/j.freeradbiomed.2017.10.390. [PMID: 29102636]
  • Frans Stellaard, Klaus von Bergmann, Thomas Sudhop, Dieter Lütjohann. The value of surrogate markers to monitor cholesterol absorption, synthesis and bioconversion to bile acids under lipid lowering therapies. The Journal of steroid biochemistry and molecular biology. 2017 05; 169(?):111-122. doi: 10.1016/j.jsbmb.2016.03.030. [PMID: 27060336]
  • Willem-Jan Keune, Jens Hausmann, Ruth Bolier, Dagmar Tolenaars, Andreas Kremer, Tatjana Heidebrecht, Robbie P Joosten, Manjula Sunkara, Andrew J Morris, Elisa Matas-Rico, Wouter H Moolenaar, Ronald P Oude Elferink, Anastassis Perrakis. Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling. Nature communications. 2016 Apr; 7(?):11248. doi: 10.1038/ncomms11248. [PMID: 27075612]
  • Zoltán Pataj, Gerhard Liebisch, Gerd Schmitz, Silke Matysik. Quantification of oxysterols in human plasma and red blood cells by liquid chromatography high-resolution tandem mass spectrometry. Journal of chromatography. A. 2016 Mar; 1439(?):82-88. doi: 10.1016/j.chroma.2015.11.015. [PMID: 26607314]
  • Aliki A Rasmiena, Christopher K Barlow, Theodore W Ng, Dedreia Tull, Peter J Meikle. High density lipoprotein efficiently accepts surface but not internal oxidised lipids from oxidised low density lipoprotein. Biochimica et biophysica acta. 2016 Feb; 1861(2):69-77. doi: 10.1016/j.bbalip.2015.11.002. [PMID: 26569052]
  • Thomas Nury, Amira Zarrouk, John J Mackrill, Mohammad Samadi, Philippe Durand, Jean-Marc Riedinger, Margaux Doria, Anne Vejux, Emeric Limagne, Dominique Delmas, Michel Prost, Thibault Moreau, Mohamed Hammami, Régis Delage-Mourroux, Nora M O'Brien, Gérard Lizard. Induction of oxiapoptophagy on 158N murine oligodendrocytes treated by 7-ketocholesterol-, 7β-hydroxycholesterol-, or 24(S)-hydroxycholesterol: Protective effects of α-tocopherol and docosahexaenoic acid (DHA; C22:6 n-3). Steroids. 2015 Jul; 99(Pt B):194-203. doi: 10.1016/j.steroids.2015.02.003. [PMID: 25683890]
  • Chitra Bhatia, Stephanie Oerum, James Bray, Kathryn L Kavanagh, Naeem Shafqat, Wyatt Yue, Udo Oppermann. Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure-activity relationships. Chemico-biological interactions. 2015 Jun; 234(?):114-25. doi: 10.1016/j.cbi.2014.12.013. [PMID: 25526675]
  • Oliver Weingärtner, Constanze Husche, Hans F Schött, Timo Speer, Michael Böhm, Charlotte M Miller, Florence McCarthy, Jogchum Plat, Dieter Lütjohann, Ulrich Laufs. Vascular effects of oxysterols and oxyphytosterols in apoE -/- mice. Atherosclerosis. 2015 May; 240(1):73-9. doi: 10.1016/j.atherosclerosis.2015.02.032. [PMID: 25765595]
  • Yalong Wang, Han Jiang, Huizhi Huang, Yanqi Xie, Yunshi Zhao, Xiuhua You, Lipeng Tang, Youqiong Wang, Wei Yin, Pengxin Qiu, Guangmei Yan, Haiyan Hu. Determination of neuroprotective oxysterols in Calculus bovis, human gallstones, and traditional Chinese medicine preparations by liquid chromatography with mass spectrometry. Journal of separation science. 2015 Mar; 38(5):796-803. doi: 10.1002/jssc.201400850. [PMID: 25545614]
  • C Helmschrodt, S Becker, J Thiery, U Ceglarek. Preanalytical standardization for reactive oxygen species derived oxysterol analysis in human plasma by liquid chromatography-tandem mass spectrometry. Biochemical and biophysical research communications. 2014 Apr; 446(3):726-30. doi: 10.1016/j.bbrc.2013.12.087. [PMID: 24370823]
  • Tadashi Ikegami, Akira Honda, Teruo Miyazaki, Motoyuki Kohjima, Makoto Nakamuta, Yasushi Matsuzaki. Increased serum oxysterol concentrations in patients with chronic hepatitis C virus infection. Biochemical and biophysical research communications. 2014 Apr; 446(3):736-40. doi: 10.1016/j.bbrc.2014.01.176. [PMID: 24525121]
  • Yoshiro Saito, Noriko Noguchi. 7-Hydroxycholestrol as a possible biomarker of cellular lipid peroxidation: difference between cellular and plasma lipid peroxidation. Biochemical and biophysical research communications. 2014 Apr; 446(3):741-4. doi: 10.1016/j.bbrc.2013.12.083. [PMID: 24380859]
  • Soliman Khatib, Jacob Vaya. Oxysterols and symptomatic versus asymptomatic human atherosclerotic plaque. Biochemical and biophysical research communications. 2014 Apr; 446(3):709-13. doi: 10.1016/j.bbrc.2013.12.116. [PMID: 24393847]
  • Christin Helmschrodt, Susen Becker, Jenny Schröter, Max Hecht, Gabriela Aust, Joachim Thiery, Uta Ceglarek. Fast LC-MS/MS analysis of free oxysterols derived from reactive oxygen species in human plasma and carotid plaque. Clinica chimica acta; international journal of clinical chemistry. 2013 Oct; 425(?):3-8. doi: 10.1016/j.cca.2013.06.022. [PMID: 23827692]
  • Satoshi Hirayama, Saori Nakagawa, Satoshi Soda, Yumiko Kamimura, Emiko Nishioka, Tsuyoshi Ueno, Yoshifumi Fukushima, Ken-ichi Higuchi, Masanori Inoue, Utako Seino, Hirotoshi Ohmura, Susumu Yamato, Takashi Miida. Ezetimibe decreases serum oxidized cholesterol without impairing bile acid synthesis in Japanese hypercholesterolemic patients. Atherosclerosis. 2013 Sep; 230(1):48-51. doi: 10.1016/j.atherosclerosis.2013.06.016. [PMID: 23958251]
  • Tijana Mitić, Steven Shave, Nina Semjonous, Iain McNae, Diego F Cobice, Gareth G Lavery, Scott P Webster, Patrick W F Hadoke, Brian R Walker, Ruth Andrew. 11β-Hydroxysteroid dehydrogenase type 1 contributes to the balance between 7-keto- and 7-hydroxy-oxysterols in vivo. Biochemical pharmacology. 2013 Jul; 86(1):146-53. doi: 10.1016/j.bcp.2013.02.002. [PMID: 23415904]
  • Kévin Ragot, John J Mackrill, Amira Zarrouk, Thomas Nury, Virginie Aires, Agnès Jacquin, Anne Athias, Jean-Paul Pais de Barros, Anne Véjux, Jean-Marc Riedinger, Dominique Delmas, Gérard Lizard. Absence of correlation between oxysterol accumulation in lipid raft microdomains, calcium increase, and apoptosis induction on 158N murine oligodendrocytes. Biochemical pharmacology. 2013 Jul; 86(1):67-79. doi: 10.1016/j.bcp.2013.02.028. [PMID: 23473804]
  • Jan de Weille, Christine Fabre, Camille Gaven, Norbert Bakalara. Similar pyruvate kinase modifications in glioblastoma cells by 7β-hydroxycholesterol and glutamine withdrawal. Biochemical pharmacology. 2013 Jul; 86(1):161-7. doi: 10.1016/j.bcp.2013.03.012. [PMID: 23537700]
  • Raymond C S Seet, Amy M L Quek, Erle C H Lim, Barry Halliwell. Biomarkers of oxidative damage are elevated among individuals with high cardiovascular risk: refining subject selection strategies for antioxidant trials. Free radical research. 2013 Apr; 47(4):283-90. doi: 10.3109/10715762.2013.769215. [PMID: 23343456]
  • Ming Long Sirius Chung, Kai Yan Eric Lee, Chung-Yung Jetty Lee. Profiling of oxidized lipid products of marine fish under acute oxidative stress. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2013 Mar; 53(?):205-13. doi: 10.1016/j.fct.2012.11.047. [PMID: 23220612]
  • Morten Blaabjerg, Dragan Marjanovic. [Cerebrotendinous xanthomatosis is a rare disorder, which requires a specific treatment]. Ugeskrift for laeger. 2013 Jan; 175(5):285-6. doi: ". [PMID: 23369332]
  • Mario Arciello, Salvatore Petta, Valerio Leoni, Gino Iannucci, Giancarlo Labbadia, Carlo Cammà, Antonio Craxì, Clara Balsano. Inverse correlation between plasma oxysterol and LDL-cholesterol levels in hepatitis C virus-infected patients. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. 2012 Mar; 44(3):245-50. doi: 10.1016/j.dld.2011.10.022. [PMID: 22154950]
  • Thomas Lundåsen, Eva-Marie Andersson, Michael Snaith, Helena Lindmark, Johanna Lundberg, Ann-Margret Östlund-Lindqvist, Bo Angelin, Mats Rudling. Inhibition of intestinal bile acid transporter Slc10a2 improves triglyceride metabolism and normalizes elevated plasma glucose levels in mice. PloS one. 2012; 7(5):e37787. doi: 10.1371/journal.pone.0037787. [PMID: 22662222]
  • Ludovic Clarion, Mathilde Schindler, Jan de Weille, Karine Lolmède, Audrey Laroche-Clary, Emmanuelle Uro-Coste, Jacques Robert, Marcel Mersel, Norbert Bakalara. 7β-Hydroxycholesterol-induced energy stress leads to sequential opposing signaling responses and to death of C6 glioblastoma cells. Biochemical pharmacology. 2012 Jan; 83(1):37-46. doi: 10.1016/j.bcp.2011.09.022. [PMID: 21983033]
  • Rodrigo T Iborra, Adriana Machado-Lima, Gabriela Castilho, Valeria S Nunes, Dulcinéia S P Abdalla, Edna R Nakandakare, Marisa Passarelli. Advanced glycation in macrophages induces intracellular accumulation of 7-ketocholesterol and total sterols by decreasing the expression of ABCA-1 and ABCG-1. Lipids in health and disease. 2011 Sep; 10(?):172. doi: 10.1186/1476-511x-10-172. [PMID: 21957962]
  • Wei Li, Moumita Ghosh, Sina Eftekhari, Xi-Ming Yuan. Lipid accumulation and lysosomal pathways contribute to dysfunction and apoptosis of human endothelial cells caused by 7-oxysterols. Biochemical and biophysical research communications. 2011 Jun; 409(4):711-6. doi: 10.1016/j.bbrc.2011.05.071. [PMID: 21621514]
  • Raymond C S Seet, Chung-Yung J Lee, Wai Mun Loke, Shan Hong Huang, Huiwen Huang, Woan Foon Looi, Eng Soh Chew, Amy M L Quek, Erle C H Lim, Barry Halliwell. Biomarkers of oxidative damage in cigarette smokers: which biomarkers might reflect acute versus chronic oxidative stress?. Free radical biology & medicine. 2011 Jun; 50(12):1787-93. doi: 10.1016/j.freeradbiomed.2011.03.019. [PMID: 21420490]
  • Paola Gamba, Gabriella Leonarduzzi, Elena Tamagno, Michela Guglielmotto, Gabriella Testa, Barbara Sottero, Simona Gargiulo, Fiorella Biasi, Alessandro Mauro, José Viña, Giuseppe Poli. Interaction between 24-hydroxycholesterol, oxidative stress, and amyloid-β in amplifying neuronal damage in Alzheimer's disease: three partners in crime. Aging cell. 2011 Jun; 10(3):403-17. doi: 10.1111/j.1474-9726.2011.00681.x. [PMID: 21272192]
  • Yongsheng Wang, Lili Wang, Yan Hu, Lantong Zhang, Zhihan Wang. Isolation and identification of two steroid compounds from Oviductus Ranae. Natural product research. 2010 Oct; 24(16):1518-22. doi: 10.1080/14786419.2010.484391. [PMID: 20835952]
  • Zhongmei Tang, F Peter Guengerich. Dansylation of unactivated alcohols for improved mass spectral sensitivity and application to analysis of cytochrome P450 oxidation products in tissue extracts. Analytical chemistry. 2010 Sep; 82(18):7706-12. doi: 10.1021/ac1015497. [PMID: 20795636]
  • R Racine, L Grandcolas, S Grison, J Stefani, O Delissen, P Gourmelon, G Veyssière, M Souidi. Cholesterol 7alpha-hydroxylase (CYP7A1) activity is modified after chronic ingestion of depleted uranium in the rat. The Journal of steroid biochemistry and molecular biology. 2010 May; 120(1):60-6. doi: 10.1016/j.jsbmb.2010.03.066. [PMID: 20362056]
  • Giovanni Pignoli, Maria Teresa Rodriguez-Estrada, Mara Mandrioli, Lorenzo Barbanti, Laura Rizzi, Giovanni Lercker. Effects of different rearing and feeding systems on lipid oxidation and antioxidant capacity of freeze-dried egg yolks. Journal of agricultural and food chemistry. 2009 Dec; 57(24):11517-27. doi: 10.1021/jf901537r. [PMID: 20000852]
  • D Lütjohann, M Marinova, B Schneider, J Oldenburg, K von Bergmann, T Bieber, I Björkhem, U Diczfalusy. 4beta-hydroxycholesterol as a marker of CYP3A4 inhibition in vivo - effects of itraconazole in man. International journal of clinical pharmacology and therapeutics. 2009 Dec; 47(12):709-15. doi: 10.5414/cpp47709. [PMID: 19954708]
  • Guihua Xu, Lei Guan, Junliang Sun, Zhen-Yu Chen. Oxidation of cholesterol and beta-sitosterol and prevention by natural antioxidants. Journal of agricultural and food chemistry. 2009 Oct; 57(19):9284-92. doi: 10.1021/jf902552s. [PMID: 19754120]
  • Raymond C S Seet, Chung-Yung J Lee, Erle C H Lim, Amy M L Quek, Leonard L L Yeo, Shan-Hong Huang, Barry Halliwell. Oxidative damage in dengue fever. Free radical biology & medicine. 2009 Aug; 47(4):375-80. doi: 10.1016/j.freeradbiomed.2009.04.035. [PMID: 19427377]
  • Akira Honda, Kouwa Yamashita, Takashi Hara, Tadashi Ikegami, Teruo Miyazaki, Mutsumi Shirai, Guorong Xu, Mitsuteru Numazawa, Yasushi Matsuzaki. Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS. Journal of lipid research. 2009 Feb; 50(2):350-7. doi: 10.1194/jlr.d800040-jlr200. [PMID: 18815436]
  • Sodeif Azadmard-Damirchi, Paresh C Dutta. A single step solid-phase extraction method for complete separation of sterol oxidation products in food lipids. Journal of chromatography. A. 2009 Jan; 1216(1):36-42. doi: 10.1016/j.chroma.2008.11.041. [PMID: 19056087]
  • Dalal Alkazemi, Grace Egeland, Jacob Vaya, Sara Meltzer, Stan Kubow. Oxysterol as a marker of atherogenic dyslipidemia in adolescence. The Journal of clinical endocrinology and metabolism. 2008 Nov; 93(11):4282-9. doi: 10.1210/jc.2008-0586. [PMID: 18713821]
  • Andrea Crosignani, Marina Del Puppo, Emma De Fabiani, Donatella Caruso, Domenico Gallisai, Maria G Mela, Maria L Melzi, Marzia Galli Kienle, Carla Colombo. Plasma oxysterols in normal and cholestatic children as indicators of the two pathways of bile acid synthesis. Clinica chimica acta; international journal of clinical chemistry. 2008 Sep; 395(1-2):84-8. doi: 10.1016/j.cca.2008.05.011. [PMID: 18538136]
  • Daniel Rodriguez-Agudo, Shunlin Ren, Eric Wong, Dalila Marques, Kaye Redford, Gregorio Gil, Phillip Hylemon, William M Pandak. Intracellular cholesterol transporter StarD4 binds free cholesterol and increases cholesteryl ester formation. Journal of lipid research. 2008 Jul; 49(7):1409-19. doi: 10.1194/jlr.m700537-jlr200. [PMID: 18403318]
  • Chung-Yung J Lee, Shan Hong Huang, Andrew M Jenner, Barry Halliwell. Measurement of F2-isoprostanes, hydroxyeicosatetraenoic products, and oxysterols from a single plasma sample. Free radical biology & medicine. 2008 Apr; 44(7):1314-22. doi: 10.1016/j.freeradbiomed.2007.12.026. [PMID: 18226605]
  • Bianca Fuhrman, Ayelet Partoush, Nina Volkova, Michael Aviram. Ox-LDL induces monocyte-to-macrophage differentiation in vivo: Possible role for the macrophage colony stimulating factor receptor (M-CSF-R). Atherosclerosis. 2008 Feb; 196(2):598-607. doi: 10.1016/j.atherosclerosis.2007.06.026. [PMID: 17675037]
  • Danuta Zapolska-Downar, Grazyna Nowicka, Grazyna Sygitowicz, Mirosław Jarosz. Anthocyanin-rich Aronox extract from Aronia melanocarpa E protects against 7beta-hydroxycholesterol-induced apoptosis of endothelial cells. Annals of nutrition & metabolism. 2008; 53(3-4):283-94. doi: 10.1159/000191290. [PMID: 19142035]
  • C Knabe, T Sudhop, K von Bergmann, D Lütjohann. Degradation of 24S-hydroxycholesterol in men is not regulated by CYP7A1. International journal of clinical pharmacology and therapeutics. 2007 Nov; 45(11):577-82. doi: 10.5414/cpp45577. [PMID: 18077921]
  • Anita Lövgren-Sandblom, Maura Heverin, Hanna Larsson, Eija Lundström, John Wahren, Ulf Diczfalusy, Ingemar Björkhem. Novel LC-MS/MS method for assay of 7alpha-hydroxy-4-cholesten-3-one in human plasma. Evidence for a significant extrahepatic metabolism. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 Sep; 856(1-2):15-9. doi: 10.1016/j.jchromb.2007.05.019. [PMID: 17561450]
  • Andrea Crosignani, Marina Del Puppo, Matteo Longo, Emma De Fabiani, Donatella Caruso, Massimo Zuin, Mauro Podda, Norman B Javitt, Marzia Galli Kienle. Changes in classic and alternative pathways of bile acid synthesis in chronic liver disease. Clinica chimica acta; international journal of clinical chemistry. 2007 Jul; 382(1-2):82-8. doi: 10.1016/j.cca.2007.03.025. [PMID: 17482152]
  • Lyubomir G Nashev, Charlie Chandsawangbhuwana, Zoltan Balazs, Atanas G Atanasov, Bernhard Dick, Felix J Frey, Michael E Baker, Alex Odermatt. Hexose-6-phosphate dehydrogenase modulates 11beta-hydroxysteroid dehydrogenase type 1-dependent metabolism of 7-keto- and 7beta-hydroxy-neurosteroids. PloS one. 2007 Jun; 2(6):e561. doi: 10.1371/journal.pone.0000561. [PMID: 17593962]
  • Yasukazu Yoshida, Yoshiro Saito, Mieko Hayakawa, Yoko Habuchi, Yasuharu Imai, Yoshiyuki Sawai, Etsuo Niki. Levels of lipid peroxidation in human plasma and erythrocytes: comparison between fatty acids and cholesterol. Lipids. 2007 May; 42(5):439-49. doi: 10.1007/s11745-007-3037-5. [PMID: 17476548]
  • M Hansson, M Olin, C-H Floren, S von Bahr, F van't Hooft, S Meaney, G Eggertsen, I Björkhem. Unique patient with cerebrotendinous xanthomatosis. Evidence for presence of a defect in a gene that is not identical to sterol 27-hydroxylase. Journal of internal medicine. 2007 May; 261(5):504-10. doi: 10.1111/j.1365-2796.2007.01782.x. [PMID: 17444890]
  • Marcello Arca, Silvia Natoli, Fausta Micheletta, Sara Riggi, Emanuele Di Angelantonio, Anna Montali, Teresa Maria Antonini, Roberto Antonini, Ulf Diczfalusy, Luigi Iuliano. Increased plasma levels of oxysterols, in vivo markers of oxidative stress, in patients with familial combined hyperlipidemia: reduction during atorvastatin and fenofibrate therapy. Free radical biology & medicine. 2007 Mar; 42(5):698-705. doi: 10.1016/j.freeradbiomed.2006.12.013. [PMID: 17291993]
  • Clett Erridge, David J Webb, Corinne M Spickett. 25-Hydroxycholesterol, 7beta-hydroxycholesterol and 7-ketocholesterol upregulate interleukin-8 expression independently of Toll-like receptor 1, 2, 4 or 6 signalling in human macrophages. Free radical research. 2007 Mar; 41(3):260-6. doi: 10.1080/10715760601070091. [PMID: 17364953]
  • Soichi Kitano, Yasukazu Yoshida, Katsumi Kawano, Nozomu Hibi, Etsuo Niki. Oxidative status of human low density lipoprotein isolated by anion-exchange high-performance liquid chromatography--assessment by total hydroxyoctadecadienoic acid, 7-hydroxycholesterol, and 8-iso-prostaglandin F(2alpha). Analytica chimica acta. 2007 Feb; 585(1):86-93. doi: 10.1016/j.aca.2006.12.032. [PMID: 17386651]
  • S Ferderbar, E C Pereira, E Apolinário, M C Bertolami, A Faludi, O Monte, L E Calliari, J E Sales, A R Gagliardi, H T Xavier, D S P Abdalla. Cholesterol oxides as biomarkers of oxidative stress in type 1 and type 2 diabetes mellitus. Diabetes/metabolism research and reviews. 2007 Jan; 23(1):35-42. doi: 10.1002/dmrr.645. [PMID: 16634125]
  • Stamatiki Roussi, Francine Gossé, Dalal Aoudé-Werner, Xin Zhang, Philippe Geoffroy, Michel Miesch, Eric Marchioni, Francis Raul. Perturbation of polyamine metabolism and its relation to cell death in human colon cancer cells treated by 7beta-hydroxycholesterol and 7beta-hydroxysitosterol. International journal of oncology. 2006 Dec; 29(6):1549-54. doi: . [PMID: 17088995]
  • Zhi-Hua Chen, Yasukazu Yoshida, Yoshiro Saito, Azusa Sekine, Noriko Noguchi, Etsuo Niki. Induction of adaptive response and enhancement of PC12 cell tolerance by 7-hydroxycholesterol and 15-deoxy-delta(12,14)-prostaglandin J2 through up-regulation of cellular glutathione via different mechanisms. The Journal of biological chemistry. 2006 May; 281(20):14440-5. doi: 10.1074/jbc.m600260200. [PMID: 16565077]
  • Y Guéguen, M Souidi, C Baudelin, N Dudoignon, S Grison, I Dublineau, C Marquette, P Voisin, P Gourmelon, J Aigueperse. Short-term hepatic effects of depleted uranium on xenobiotic and bile acid metabolizing cytochrome P450 enzymes in the rat. Archives of toxicology. 2006 Apr; 80(4):187-95. doi: 10.1007/s00204-005-0027-3. [PMID: 16231126]
  • C Prunet, J M Petit, A Ecarnot-Laubriet, A Athias, C Miguet-Alfonsi, J F Rohmer, E Steinmetz, D Néel, P Gambert, G Lizard. High circulating levels of 7beta- and 7alpha-hydroxycholesterol and presence of apoptotic and oxidative markers in arterial lesions of normocholesterolemic atherosclerotic patients undergoing endarterectomy. Pathologie-biologie. 2006 Feb; 54(1):22-32. doi: 10.1016/j.patbio.2004.11.002. [PMID: 16376175]
  • Stefano Ginanni Corradini, Fausta Micheletta, Silvia Natoli, Massimo Iappelli, Emanuele Di Angelantonio, Rosanna De Marco, Walter Elisei, Maria Siciliano, Massimo Rossi, Pasquale Berloco, Adolfo Francesco Attili, Ulf Diczfalusy, Luigi Iuliano. High preoperative recipient plasma 7beta-hydroxycholesterol is associated with initial poor graft function after liver transplantation. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. 2005 Dec; 11(12):1494-504. doi: 10.1002/lt.20524. [PMID: 16258953]
  • Mun-Chual Rho, Young Kook Kim, Jong Sun Chang, Hyun Sun Lee, Jin Ah Baek, Mi Yeon Chung, Han Cheol Lee, Hwan Woo Lee, Byong Yong Rhim, Michael A Reidy, Koanhoi Kim. 7-Ketocholesterol predisposes human aorta smooth muscle cells to Fas-mediated death. Journal of molecular and cellular cardiology. 2005 Nov; 39(5):823-32. doi: 10.1016/j.yjmcc.2005.07.018. [PMID: 16198370]
  • Wei Li, Anna Hellsten, Li-Hua Xu, Da-Ming Zhuang, Katarina Jansson, Ulf T Brunk, Xi-Ming Yuan. Foam cell death induced by 7beta-hydroxycholesterol is mediated by labile iron-driven oxidative injury: mechanisms underlying induction of ferritin in human atheroma. Free radical biology & medicine. 2005 Oct; 39(7):864-75. doi: 10.1016/j.freeradbiomed.2005.05.006. [PMID: 16140207]
  • Hyun Sun Lee, Jong Sun Chang, Jin Ah Baek, Mi Yeon Chung, Han Cheol Lee, Byung Yong Rhim, Dai Eun Sok, Mun-Chual Rho, Young Kook Kim, Koanhoi Kim. TNF-alpha activates death pathway in human aorta smooth muscle cell in the presence of 7-ketocholesterol. Biochemical and biophysical research communications. 2005 Aug; 333(4):1093-9. doi: 10.1016/j.bbrc.2005.05.196. [PMID: 15993097]
  • M Napolitano, E Bravo. Lipid metabolism and TNF-alpha secretion in response to dietary sterols in human monocyte derived macrophages. European journal of clinical investigation. 2005 Aug; 35(8):482-90. doi: 10.1111/j.1365-2362.2005.01523.x. [PMID: 16101668]
  • Robert Ringseis, Klaus Eder. Effects of dietary fat and oxidized cholesterol on gene expression in rat liver as assessed by cDNA expression array analysis. European journal of nutrition. 2005 Jun; 44(4):231-41. doi: 10.1007/s00394-004-0515-x. [PMID: 15309417]
  • Marina Del Puppo, Andrea Crosignani, Matteo Longo, Massimo Zuin, Mauro Podda, Giovanni Galli, Emma De Fabiani, Pierangela Ciuffreda, Enzo Santaniello, Norman B Javitt, Marzia Galli Kienle. A minimally invasive technique for the evaluation of the regulatory steps of the two major pathways of bile acid synthesis. Clinica chimica acta; international journal of clinical chemistry. 2005 May; 355(1-2):23-31. doi: 10.1016/j.cccn.2004.11.037. [PMID: 15820474]
  • S Lemaire-Ewing, C Prunet, T Montange, A Vejux, A Berthier, G Bessède, L Corcos, P Gambert, D Néel, G Lizard. Comparison of the cytotoxic, pro-oxidant and pro-inflammatory characteristics of different oxysterols. Cell biology and toxicology. 2005 Mar; 21(2):97-114. doi: 10.1007/s10565-005-0141-2. [PMID: 16142584]
  • S Roussi, A Winter, F Gosse, D Werner, X Zhang, E Marchioni, P Geoffroy, M Miesch, F Raul. Different apoptotic mechanisms are involved in the antiproliferative effects of 7beta-hydroxysitosterol and 7beta-hydroxycholesterol in human colon cancer cells. Cell death and differentiation. 2005 Feb; 12(2):128-35. doi: 10.1038/sj.cdd.4401530. [PMID: 15550935]
  • Mona Boaz, Luigi Iuliano, Jonathan Himmelfarb, Zipora Matas, Fausta Micheletta, Ellen McMonagle, Victoria Friedman, Silvia Natoli, Gabriella Gvirtz, Alexander Biro, Shmuel Smetana, Gideon Sabo, Uzi Gafter, Talia Weinstein. Baseline oxysterols and other markers of oxidative stress, inflammation and malnutrition in the vitamin e and intima media thickness progression in end-stage renal disease (VIPER) cohort. Nephron. Clinical practice. 2005; 100(4):c111-9. doi: 10.1159/000085290. [PMID: 15849477]
  • Wei Li, Anna Hellsten, Jerome Dinga Nyhalah, Xi-Ming Yuan. Enhanced expression of natural resistance-associated macrophage protein 1 in atherosclerotic lesions may be associated with oxidized lipid-induced apoptosis. Annals of the New York Academy of Sciences. 2004 Dec; 1030(?):202-7. doi: 10.1196/annals.1329.026. [PMID: 15659799]
  • Stefan Holdenrieder, Dieter Lütjohann, Sandra Geiger, Klaus von Bergmann, Petra Stieber, Gerhard F Hamann. Does brain specific 24S-hydroxycholesterol in plasma indicate the disruption of the blood-brain barrier in patients with ischemic stroke?. Neuroscience letters. 2004 Sep; 368(2):201-4. doi: 10.1016/j.neulet.2004.07.012. [PMID: 15351449]
  • Yasukazu Yoshida, Etsuo Niki. Detection of lipid peroxidation in vivo: total hydroxyoctadecadienoic acid and 7-hydroxycholesterol as oxidative stress marker. Free radical research. 2004 Aug; 38(8):787-94. doi: 10.1080/10715760410001700460. [PMID: 15493451]
  • Roberto A S Schweizer, Marcel Zürcher, Zoltan Balazs, Bernhard Dick, Alex Odermatt. Rapid hepatic metabolism of 7-ketocholesterol by 11beta-hydroxysteroid dehydrogenase type 1: species-specific differences between the rat, human, and hamster enzyme. The Journal of biological chemistry. 2004 Apr; 279(18):18415-24. doi: 10.1074/jbc.m313615200. [PMID: 14973125]
  • Yasukazu Yoshida, Nanako Itoh, Yoshiro Saito, Mieko Hayakawa, Etsuo Niki. Application of water-soluble radical initiator, 2,2'-azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride, to a study of oxidative stress. Free radical research. 2004 Apr; 38(4):375-84. doi: 10.1080/1071576042000191763. [PMID: 15190934]
  • Fausta Micheletta, Silvia Natoli, Maria Misuraca, Enrico Sbarigia, Ulf Diczfalusy, Luigi Iuliano. Vitamin E supplementation in patients with carotid atherosclerosis: reversal of altered oxidative stress status in plasma but not in plaque. Arteriosclerosis, thrombosis, and vascular biology. 2004 Jan; 24(1):136-40. doi: 10.1161/01.atv.0000104028.07929.72. [PMID: 14592846]
  • Keri L H Carpenter, Peter J Kirkpatrick, Peter L Weissberg, Iain R Challis, Ian F Dennis, Mark A Freeman, Malcolm J Mitchinson. Oral alpha-tocopherol supplementation inhibits lipid oxidation in established human atherosclerotic lesions. Free radical research. 2003 Nov; 37(11):1235-44. doi: 10.1080/10715760310001604143. [PMID: 14703736]
  • Tomi-Pekka Tuomainen, Ulf Diczfalusy, Jari Kaikkonen, Kristiina Nyyssönen, Jukka T Salonen. Serum ferritin concentration is associated with plasma levels of cholesterol oxidation products in man. Free radical biology & medicine. 2003 Oct; 35(8):922-8. doi: 10.1016/s0891-5849(03)00433-7. [PMID: 14556856]
  • María J Petrón, José A García-Regueiro, Lourdes Martín, Elena Muriel, Teresa Antequera. Identification and quantification of cholesterol and cholesterol oxidation products in different types of Iberian hams. Journal of agricultural and food chemistry. 2003 Sep; 51(19):5786-91. doi: 10.1021/jf034100a. [PMID: 12952434]
  • Steve Meaney, Amir Babiker, Dieter Lütjohann, Ulf Diczfalusy, Magnus Axelson, Ingemar Björkhem. On the origin of the cholestenoic acids in human circulation. Steroids. 2003 Sep; 68(7-8):595-601. doi: 10.1016/s0039-128x(03)00081-3. [PMID: 12957664]
  • K Nakamura, K Chijiiwa, S Kuroki, T Naito, A Mizuta, M Tanaka. Serum 7alpha-hydroxycholesterol levels during liver regeneration after hepatectomy in humans. Hepato-gastroenterology. 2003 Sep; 50(53):1593-7. doi: NULL. [PMID: 14571793]
  • Mary Y Chang, Christina Tsoi, Thomas N Wight, Alan Chait. Lysophosphatidylcholine regulates synthesis of biglycan and the proteoglycan form of macrophage colony stimulating factor. Arteriosclerosis, thrombosis, and vascular biology. 2003 May; 23(5):809-15. doi: 10.1161/01.atv.0000069208.20268.d0. [PMID: 12663372]
  • Serge Monier, Mohammad Samadi, Céline Prunet, Mikeäl Denance, Aline Laubriet, Anne Athias, Arnaud Berthier, Eric Steinmetz, Günter Jürgens, Anne Nègre-Salvayre, Ginette Bessède, Stéphanie Lemaire-Ewing, Dominique Néel, Philippe Gambert, Gérard Lizard. Impairment of the cytotoxic and oxidative activities of 7 beta-hydroxycholesterol and 7-ketocholesterol by esterification with oleate. Biochemical and biophysical research communications. 2003 Apr; 303(3):814-24. doi: 10.1016/s0006-291x(03)00412-1. [PMID: 12670484]
  • Robert Ringseis, Klaus Eder. Insufficient dietary vitamin e increases the concentration of 7beta-hydroxycholesterol in tissues of rats fed salmon oil. The Journal of nutrition. 2002 Dec; 132(12):3732-5. doi: 10.1093/jn/132.12.3732. [PMID: 12468614]
  • Sueli Regina Baggio, Eduardo Vicente, Neura Bragagnolo. Cholesterol oxides, cholesterol, total lipid, and fatty acid composition in turkey meat. Journal of agricultural and food chemistry. 2002 Oct; 50(21):5981-6. doi: 10.1021/jf020025c. [PMID: 12358469]