Fluorene (BioDeep_00000003125)

 

Secondary id: BioDeep_00000864067, BioDeep_00001867687

human metabolite blood metabolite natural product


代谢物信息卡片


2,2-Methylenebiphenyl

化学式: C13H10 (166.0782)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 18.34%

Reviewed

Last reviewed on 2024-08-14.

Cite this Page

Fluorene. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/fluorene (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000003125). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1C2=CC=CC=C2C2=CC=CC=C12
InChI: InChI=1S/C13H10/c1-3-7-12-10(5-1)9-11-6-2-4-8-13(11)12/h1-8H,9H2

描述信息

Fluorene, also known as diphenylenemethane or 9h-fluorene, is a member of the class of compounds known as fluorenes. Fluorenes are compounds containing a fluorene moiety, which consists of two benzene rings connected through either a cyclopentane, cyclopentene, or cyclopenta-1,3-diene. Fluorene is practically insoluble (in water) and an extremely weak acidic compound (based on its pKa). Fluorene can be found in corn, which makes fluorene a potential biomarker for the consumption of this food product. Fluorene is formally rated as an unfounded non-carcinogenic (IARC 3) potentially toxic compound. Fluorene , or 9H-fluorene, is a polycyclic aromatic hydrocarbon. It forms white crystals that exhibit a characteristic, aromatic odor similar to that of naphthalene. It is combustible. It has a violet fluorescence, hence its name. For commercial purposes it is obtained from coal tar. It is insoluble in water and soluble in many organic solvents . PAHs are carcinogens and have been associated with the increased risk of skin, respiratory tract, bladder, stomach, and kidney cancers. They may also cause reproductive effects and depress the immune system (L10) (T3DB).
D009676 - Noxae > D002273 - Carcinogens

同义名列表

9 个代谢物同义名

2,2-Methylenebiphenyl; O-Biphenylenemethane; Diphenylenemethane; 9H-Fluorene; 9H FLUORENE; FLUORENE; Fluoren; Fluorene; Fluorene



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(2)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

15 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ALB, AXIN2, CAT, CYP1A1, HMGB1, HPGDS, PIK3CA, PMP2, PSMA1
Peripheral membrane protein 5 ACHE, CYP1A1, CYP1B1, HMGB1, RS1
Endoplasmic reticulum membrane 3 CYP1A1, CYP1B1, EPHX1
Nucleus 6 ACHE, ALB, AXIN2, HMGB1, PMP2, PSMA1
cytosol 9 ALB, AXIN2, CAT, EHHADH, HPGDS, PIK3CA, PMP2, PRF1, PSMA1
centrosome 3 ALB, AXIN2, PSMA1
nucleoplasm 4 CD2, HMGB1, HPGDS, PSMA1
Cell membrane 6 ACHE, CD2, HMGB1, ITGAM, PRF1, RS1
lamellipodium 1 PIK3CA
Multi-pass membrane protein 1 PRF1
Synapse 1 ACHE
cell surface 5 ACHE, CD2, HMGB1, ITGAM, TNR
glutamatergic synapse 1 TNR
Golgi apparatus 4 ACHE, ALB, ATRN, CD2
mitochondrial inner membrane 1 CYP1A1
neuromuscular junction 1 ACHE
endosome 1 HMGB1
plasma membrane 8 ACHE, ATRN, AXIN2, CD2, HMGB1, ITGAM, PIK3CA, PRF1
Membrane 5 ACHE, CAT, CYP1B1, ITGAM, PRF1
extracellular exosome 6 ALB, ATRN, CAT, ITGAM, PMP2, PSMA1
endoplasmic reticulum 2 ALB, HMGB1
extracellular space 7 ACHE, ALB, ATRN, HMGB1, ITGAM, RS1, TNR
perinuclear region of cytoplasm 2 ACHE, PIK3CA
Schaffer collateral - CA1 synapse 1 TNR
intercalated disc 1 PIK3CA
mitochondrion 3 CAT, CYP1A1, CYP1B1
protein-containing complex 4 ALB, CAT, CD2, RS1
intracellular membrane-bounded organelle 4 CAT, CYP1A1, CYP1B1, HPGDS
Microsome membrane 3 CYP1A1, CYP1B1, EPHX1
Single-pass type I membrane protein 3 ATRN, CD2, ITGAM
Secreted 5 ACHE, ALB, HMGB1, PRF1, RS1
extracellular region 7 ACHE, ALB, CAT, CD2, HMGB1, PRF1, TNR
cytoplasmic side of plasma membrane 1 CD2
[Isoform 2]: Secreted 1 ATRN
mitochondrial matrix 1 CAT
Extracellular side 3 ACHE, HMGB1, RS1
anchoring junction 1 ALB
photoreceptor inner segment 1 RS1
external side of plasma membrane 3 CD2, ITGAM, RS1
Secreted, extracellular space, extracellular matrix 1 TNR
beta-catenin destruction complex 1 AXIN2
cell-cell junction 1 CD2
Mitochondrion inner membrane 1 CYP1A1
Membrane raft 2 ITGAM, TNR
focal adhesion 1 CAT
Peroxisome 2 CAT, EHHADH
basement membrane 1 ACHE
Peroxisome matrix 1 CAT
peroxisomal matrix 2 CAT, EHHADH
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 TNR
neuron to neuron synapse 1 RS1
ciliary basal body 1 ALB
Chromosome 1 HMGB1
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
Lipid-anchor, GPI-anchor 1 ACHE
[Isoform 3]: Secreted 1 ATRN
endosome lumen 1 PRF1
specific granule membrane 1 ITGAM
tertiary granule membrane 1 ITGAM
side of membrane 1 ACHE
myelin sheath 1 PMP2
plasma membrane raft 1 ITGAM
ficolin-1-rich granule lumen 2 CAT, HMGB1
proteasome complex 1 PSMA1
secretory granule lumen 2 CAT, HMGB1
endoplasmic reticulum lumen 1 ALB
transcription repressor complex 1 HMGB1
platelet alpha granule lumen 1 ALB
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
Single-pass type III membrane protein 1 EPHX1
immunological synapse 1 PRF1
perineuronal net 1 TNR
proteasome core complex 1 PSMA1
proteasome core complex, alpha-subunit complex 1 PSMA1
endoplasmic reticulum-Golgi intermediate compartment 1 HMGB1
synaptic cleft 1 ACHE
[Isoform 1]: Cell membrane 1 ATRN
condensed chromosome 1 HMGB1
integrin complex 1 ITGAM
catalase complex 1 CAT
alphav-beta3 integrin-HMGB1 complex 1 HMGB1
integrin alphaM-beta2 complex 1 ITGAM
Cytolytic granule 1 PRF1
cytolytic granule lumen 1 PRF1
tenascin complex 1 TNR
[Isoform H]: Cell membrane 1 ACHE
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
ciliary transition fiber 1 ALB


文献列表

  • Hong-Peng Shi, Ying-Hao Zhao, Mei-Lin Zheng, Cheng-Yan Gong, Lei Yan, Ying Liu, Yong-Ming Luo, Zhi-Pei Liu. Arsenic effectively improves the degradation of fluorene by Rhodococcus sp. 2021 under the combined pollution of arsenic and fluorene. Chemosphere. 2024 Apr; 353(?):141635. doi: 10.1016/j.chemosphere.2024.141635. [PMID: 38447897]
  • Lei Zhao, Zhenzhen Han, Mengying Zhou, Cong Lyu, Yu Li. Field measures of strengthen plant-microbial remediation of PAHs-FQs compound pollution. Environmental science and pollution research international. 2023 May; ?(?):. doi: 10.1007/s11356-023-27618-6. [PMID: 37202637]
  • Falin He, Rutao Liu, Guang Tian, Yuntao Qi, Tingting Wang. Ecotoxicological evaluation of oxidative stress-mediated neurotoxic effects, genetic toxicity, behavioral disorders, and the corresponding mechanisms induced by fluorene-contaminated soil targeted to earthworm (Eisenia fetida) brain. The Science of the total environment. 2023 Feb; 871(?):162014. doi: 10.1016/j.scitotenv.2023.162014. [PMID: 36740067]
  • Hongyu Lu, Chengxun Deng, Zhimin Yu, Dianya Zhang, Weiping Li, Jun Huang, Teng Bao, Xiaowei Liu. Synergistic degradation of fluorene in soil by dielectric barrier discharge plasma combined with P25/NH2-MIL-125(Ti). Chemosphere. 2022 Jun; 296(?):133950. doi: 10.1016/j.chemosphere.2022.133950. [PMID: 35176305]
  • Maria Helena Guerra Andersen, Anne Thoustrup Saber, Marie Frederiksen, Per Axel Clausen, Camilla Sandal Sejbaek, Caroline Hallas Hemmingsen, Niels E Ebbehøj, Julia Catalán, Kukka Aimonen, Joonas Koivisto, Steffen Loft, Peter Møller, Ulla Vogel. Occupational exposure and markers of genetic damage, systemic inflammation and lung function: a Danish cross-sectional study among air force personnel. Scientific reports. 2021 09; 11(1):17998. doi: 10.1038/s41598-021-97382-5. [PMID: 34504215]
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  • Yuan-Yuei Chen, Chung-Ching Wang, Tung-Wei Kao, Hui-Fang Yang, Yu-Shan Sun, Wei-Liang Chen. Detrimental association between quadriceps strength and exposure to polycyclic aromatic hydrocarbons in elderly adults. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. 2020 Aug; 45(8):829-834. doi: 10.1139/apnm-2019-0808. [PMID: 31955601]
  • Ayman Alhamdow, Yona J Essig, Annette M Krais, Per Gustavsson, Håkan Tinnerberg, Christian H Lindh, Jessika Hagberg, Pål Graff, Maria Albin, Karin Broberg. Fluorene exposure among PAH-exposed workers is associated with epigenetic markers related to lung cancer. Occupational and environmental medicine. 2020 07; 77(7):488-495. doi: 10.1136/oemed-2020-106413. [PMID: 32385190]
  • Limei Sun, Yuhang Ling, Jiahui Jiang, Danting Wang, Junxia Wang, Jieyi Li, Xuedong Wang, Huili Wang. Differential mechanisms regarding triclosan vs. bisphenol A and fluorene-9-bisphenol induced zebrafish lipid-metabolism disorders by RNA-Seq. Chemosphere. 2020 Jul; 251(?):126318. doi: 10.1016/j.chemosphere.2020.126318. [PMID: 32143076]
  • Kenneth W Fent, Christine Toennis, Deborah Sammons, Shirley Robertson, Stephen Bertke, Antonia M Calafat, Joachim D Pleil, M Ariel Geer Wallace, Steve Kerber, Denise Smith, Gavin P Horn. Firefighters' absorption of PAHs and VOCs during controlled residential fires by job assignment and fire attack tactic. Journal of exposure science & environmental epidemiology. 2020 03; 30(2):338-349. doi: 10.1038/s41370-019-0145-2. [PMID: 31175324]
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  • Friederike Schlüter, Bart Jan Ravoo, Fabio Rizzo. Self-assembled multilayer surfaces of highly fluorescent spirobifluorene-based dye for label-free protein recognition. Journal of materials chemistry. B. 2019 08; 7(32):4933-4939. doi: 10.1039/c9tb00854c. [PMID: 31411615]
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  • Janah Shaya, Mayeul Collot, Frédéric Bénailly, Najiba Mahmoud, Yves Mély, Benoît Y Michel, Andrey S Klymchenko, Alain Burger. Turn-on Fluorene Push-Pull Probes with High Brightness and Photostability for Visualizing Lipid Order in Biomembranes. ACS chemical biology. 2017 12; 12(12):3022-3030. doi: 10.1021/acschembio.7b00658. [PMID: 29053920]
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