Fluorene (BioDeep_00000003125)

 

Secondary id: BioDeep_00000864067, BioDeep_00001867687

human metabolite blood metabolite


代谢物信息卡片


2,2-Methylenebiphenyl

化学式: C13H10 (166.078246)
中文名称: 芴
谱图信息: 最多检出来源 Homo sapiens(blood) 0.03%

Reviewed

Last reviewed on 2024-08-14.

Cite this Page

Fluorene. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/fluorene (retrieved 2024-11-05) (BioDeep RN: BioDeep_00000003125). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1C2=CC=CC=C2C2=CC=CC=C12
InChI: InChI=1S/C13H10/c1-3-7-12-10(5-1)9-11-6-2-4-8-13(11)12/h1-8H,9H2

描述信息

Fluorene, also known as diphenylenemethane or 9h-fluorene, is a member of the class of compounds known as fluorenes. Fluorenes are compounds containing a fluorene moiety, which consists of two benzene rings connected through either a cyclopentane, cyclopentene, or cyclopenta-1,3-diene. Fluorene is practically insoluble (in water) and an extremely weak acidic compound (based on its pKa). Fluorene can be found in corn, which makes fluorene a potential biomarker for the consumption of this food product. Fluorene is formally rated as an unfounded non-carcinogenic (IARC 3) potentially toxic compound. Fluorene , or 9H-fluorene, is a polycyclic aromatic hydrocarbon. It forms white crystals that exhibit a characteristic, aromatic odor similar to that of naphthalene. It is combustible. It has a violet fluorescence, hence its name. For commercial purposes it is obtained from coal tar. It is insoluble in water and soluble in many organic solvents . PAHs are carcinogens and have been associated with the increased risk of skin, respiratory tract, bladder, stomach, and kidney cancers. They may also cause reproductive effects and depress the immune system (L10) (T3DB).
D009676 - Noxae > D002273 - Carcinogens

同义名列表

7 个代谢物同义名

2,2-Methylenebiphenyl; O-Biphenylenemethane; Diphenylenemethane; 9H-Fluorene; 9H FLUORENE; FLUORENE; Fluoren



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(2)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hong-Peng Shi, Ying-Hao Zhao, Mei-Lin Zheng, Cheng-Yan Gong, Lei Yan, Ying Liu, Yong-Ming Luo, Zhi-Pei Liu. Arsenic effectively improves the degradation of fluorene by Rhodococcus sp. 2021 under the combined pollution of arsenic and fluorene. Chemosphere. 2024 Apr; 353(?):141635. doi: 10.1016/j.chemosphere.2024.141635. [PMID: 38447897]
  • Lei Zhao, Zhenzhen Han, Mengying Zhou, Cong Lyu, Yu Li. Field measures of strengthen plant-microbial remediation of PAHs-FQs compound pollution. Environmental science and pollution research international. 2023 May; ?(?):. doi: 10.1007/s11356-023-27618-6. [PMID: 37202637]
  • Falin He, Rutao Liu, Guang Tian, Yuntao Qi, Tingting Wang. Ecotoxicological evaluation of oxidative stress-mediated neurotoxic effects, genetic toxicity, behavioral disorders, and the corresponding mechanisms induced by fluorene-contaminated soil targeted to earthworm (Eisenia fetida) brain. The Science of the total environment. 2023 Feb; 871(?):162014. doi: 10.1016/j.scitotenv.2023.162014. [PMID: 36740067]
  • Hongyu Lu, Chengxun Deng, Zhimin Yu, Dianya Zhang, Weiping Li, Jun Huang, Teng Bao, Xiaowei Liu. Synergistic degradation of fluorene in soil by dielectric barrier discharge plasma combined with P25/NH2-MIL-125(Ti). Chemosphere. 2022 Jun; 296(?):133950. doi: 10.1016/j.chemosphere.2022.133950. [PMID: 35176305]
  • Maria Helena Guerra Andersen, Anne Thoustrup Saber, Marie Frederiksen, Per Axel Clausen, Camilla Sandal Sejbaek, Caroline Hallas Hemmingsen, Niels E Ebbehøj, Julia Catalán, Kukka Aimonen, Joonas Koivisto, Steffen Loft, Peter Møller, Ulla Vogel. Occupational exposure and markers of genetic damage, systemic inflammation and lung function: a Danish cross-sectional study among air force personnel. Scientific reports. 2021 09; 11(1):17998. doi: 10.1038/s41598-021-97382-5. [PMID: 34504215]
  • Eirini Chrysochou, Panagiotis Georgios Kanellopoulos, Konstantinos G Koukoulakis, Aikaterini Sakellari, Sotirios Karavoltsos, Minas Minaidis, Evangelos Bakeas. Heart Failure and PAHs, OHPAHs, and Trace Elements Levels in Human Serum: Results from a Preliminary Pilot Study in Greek Population and the Possible Impact of Air Pollution. Molecules (Basel, Switzerland). 2021 May; 26(11):. doi: 10.3390/molecules26113207. [PMID: 34071927]
  • Yuan-Yuei Chen, Chung-Ching Wang, Tung-Wei Kao, Hui-Fang Yang, Yu-Shan Sun, Wei-Liang Chen. Detrimental association between quadriceps strength and exposure to polycyclic aromatic hydrocarbons in elderly adults. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. 2020 Aug; 45(8):829-834. doi: 10.1139/apnm-2019-0808. [PMID: 31955601]
  • Ayman Alhamdow, Yona J Essig, Annette M Krais, Per Gustavsson, Håkan Tinnerberg, Christian H Lindh, Jessika Hagberg, Pål Graff, Maria Albin, Karin Broberg. Fluorene exposure among PAH-exposed workers is associated with epigenetic markers related to lung cancer. Occupational and environmental medicine. 2020 07; 77(7):488-495. doi: 10.1136/oemed-2020-106413. [PMID: 32385190]
  • Limei Sun, Yuhang Ling, Jiahui Jiang, Danting Wang, Junxia Wang, Jieyi Li, Xuedong Wang, Huili Wang. Differential mechanisms regarding triclosan vs. bisphenol A and fluorene-9-bisphenol induced zebrafish lipid-metabolism disorders by RNA-Seq. Chemosphere. 2020 Jul; 251(?):126318. doi: 10.1016/j.chemosphere.2020.126318. [PMID: 32143076]
  • Kenneth W Fent, Christine Toennis, Deborah Sammons, Shirley Robertson, Stephen Bertke, Antonia M Calafat, Joachim D Pleil, M Ariel Geer Wallace, Steve Kerber, Denise Smith, Gavin P Horn. Firefighters' absorption of PAHs and VOCs during controlled residential fires by job assignment and fire attack tactic. Journal of exposure science & environmental epidemiology. 2020 03; 30(2):338-349. doi: 10.1038/s41370-019-0145-2. [PMID: 31175324]
  • Giselle Torres-Farradá, Ana M Manzano-León, François Rineau, Miguel Ramos Leal, Sofie Thijs, Inge Jambon, Jenny Put, Jan Czech, Gilda Guerra Rivera, Robert Carleer, Jaco Vangronsveld. Biodegradation of polycyclic aromatic hydrocarbons by native Ganoderma sp. strains: identification of metabolites and proposed degradation pathways. Applied microbiology and biotechnology. 2019 Sep; 103(17):7203-7215. doi: 10.1007/s00253-019-09968-9. [PMID: 31256229]
  • Friederike Schlüter, Bart Jan Ravoo, Fabio Rizzo. Self-assembled multilayer surfaces of highly fluorescent spirobifluorene-based dye for label-free protein recognition. Journal of materials chemistry. B. 2019 08; 7(32):4933-4939. doi: 10.1039/c9tb00854c. [PMID: 31411615]
  • Tingxin Yang, Yujing Zuo, Yu Zhang, Zhiming Gou, Xiaoni Wang, Weiying Lin. Novel fluorene-based fluorescent probe with excellent stability for selective detection of SCN- and its applications in paper-based sensing and bioimaging. Journal of materials chemistry. B. 2019 07; 7(30):4649-4654. doi: 10.1039/c9tb00742c. [PMID: 31364673]
  • Petra Kubincová, Eliška Sychrová, Jan Raška, Amrita Basu, Affiefa Yawer, Aneta Dydowiczová, Pavel Babica, Iva Sovadinová. Polycyclic Aromatic Hydrocarbons and Endocrine Disruption: Role of Testicular Gap Junctional Intercellular Communication and Connexins. Toxicological sciences : an official journal of the Society of Toxicology. 2019 05; 169(1):70-83. doi: 10.1093/toxsci/kfz023. [PMID: 30668803]
  • Waraporn Chouychai, Theerarat Swangying, Khanitta Somtrakoon, Hung Lee. Growth and Phytoremediation Efficiency of Winged Bean in Fluorene- and Pyrene-Contaminated Soil. Bulletin of environmental contamination and toxicology. 2018 Nov; 101(5):631-636. doi: 10.1007/s00128-018-2479-1. [PMID: 30368575]
  • Huanyu Bao, Shaowei Hou, Hao Niu, Kai Tian, Xueping Liu, Fuyong Wu. Status, sources, and risk assessment of polycyclic aromatic hydrocarbons in urban soils of Xi'an, China. Environmental science and pollution research international. 2018 Jul; 25(19):18947-18959. doi: 10.1007/s11356-018-1928-z. [PMID: 29717431]
  • Janah Shaya, Mayeul Collot, Frédéric Bénailly, Najiba Mahmoud, Yves Mély, Benoît Y Michel, Andrey S Klymchenko, Alain Burger. Turn-on Fluorene Push-Pull Probes with High Brightness and Photostability for Visualizing Lipid Order in Biomembranes. ACS chemical biology. 2017 12; 12(12):3022-3030. doi: 10.1021/acschembio.7b00658. [PMID: 29053920]
  • Ruoyu Zhan, Bin Liu. End Functionalized Nonionic Water-Dispersible Conjugated Polymers. Macromolecular rapid communications. 2017 Sep; 38(18):. doi: 10.1002/marc.201700010. [PMID: 28508508]
  • Damien Barbeau, Simon Lutier, Marie Marques, Renaud Persoons, Anne Maitre. Comparison of gaseous polycyclic aromatic hydrocarbon metabolites according to their specificity as biomarkers of occupational exposure: Selection of 2-hydroxyfluorene and 2-hydroxyphenanthrene. Journal of hazardous materials. 2017 Jun; 332(?):185-194. doi: 10.1016/j.jhazmat.2017.03.011. [PMID: 28324712]
  • Zhaobin Zhang, Ying Hu, Jilong Guo, Tong Yu, Libei Sun, Xuan Xiao, Desheng Zhu, Tsuyoshi Nakanishi, Youhei Hiromori, Junyu Li, Xiaolin Fan, Yi Wan, Siyu Cheng, Jun Li, Xuan Guo, Jianying Hu. Fluorene-9-bisphenol is anti-oestrogenic and may cause adverse pregnancy outcomes in mice. Nature communications. 2017 03; 8(?):14585. doi: 10.1038/ncomms14585. [PMID: 28248286]
  • Roberto Barone, Margherita-Gabriella de Biasi, Vincenzo Piccialli, Lorenzo de Napoli, Giorgia Oliviero, Nicola Borbone, Gennaro Piccialli. Degradation of some representative polycyclic aromatic hydrocarbons by the water-soluble protein extracts from Zea mays L. cv PR32-B10. Chemosphere. 2016 Oct; 160(?):258-65. doi: 10.1016/j.chemosphere.2016.06.069. [PMID: 27391049]
  • Yongmei Jia, Pengcheng Gao, Yuan Zhuang, Mao Miao, Xiaoding Lou, Fan Xia. Facile Probe Design: Fluorescent Amphiphilic Nucleic Acid Probes without Quencher Providing Telomerase Activity Imaging Inside Living Cells. Analytical chemistry. 2016 06; 88(12):6621-6. doi: 10.1021/acs.analchem.6b01777. [PMID: 27223599]
  • Hongbo Yuan, Yibing Fan, Chengfen Xing, Ruimin Niu, Ran Chai, Yong Zhan, Junjie Qi, Hailong An, Jialiang Xu. Conjugated Polymer-Based Hybrid Materials for Turn-On Detection of CO2 in Plant Photosynthesis. Analytical chemistry. 2016 06; 88(12):6593-7. doi: 10.1021/acs.analchem.6b01489. [PMID: 27252118]
  • Bian Liu, Chunrong Jia. Effects of profession on urinary PAH metabolite levels in the US population. International archives of occupational and environmental health. 2016 Jan; 89(1):123-35. doi: 10.1007/s00420-015-1057-7. [PMID: 25952314]
  • Haifeng Sun, Jing Shi, Shuai Guo, Yong Zhang, Lusha Duan. In situ determination of the depuration of three- and four-ringed polycyclic aromatic hydrocarbons co-adsorbed onto mangrove leaf surfaces. Environmental pollution (Barking, Essex : 1987). 2016 Jan; 208(Pt B):688-95. doi: 10.1016/j.envpol.2015.10.047. [PMID: 26561206]
  • Xiling Yue, Zach Armijo, Kevan King, Mykhailo V Bondar, Alma R Morales, Andrew Frazer, Ivan A Mikhailov, Olga V Przhonska, Kevin D Belfield. Steady-state and femtosecond transient absorption spectroscopy of new two-photon absorbing fluorene-containing quinolizinium cation membrane probes. ACS applied materials & interfaces. 2015 Feb; 7(4):2833-46. doi: 10.1021/am508093p. [PMID: 25622309]
  • Arne Bahr, Anko Fischer, Carsten Vogt, Petra Bombach. Evidence of polycyclic aromatic hydrocarbon biodegradation in a contaminated aquifer by combined application of in situ and laboratory microcosms using (13)C-labelled target compounds. Water research. 2015 Feb; 69(?):100-109. doi: 10.1016/j.watres.2014.10.045. [PMID: 25437342]
  • Seyed Yahya Salehi-Lisar, Somaye Deljoo, Ahmad Mosen Harzandi. Fluorene and Phenanthrene Uptake and Accumulation by Wheat, Alfalfa and Sunflower from the Contaminated Soil. International journal of phytoremediation. 2015; 17(12):1145-52. doi: 10.1080/15226514.2015.1045123. [PMID: 25950194]
  • Mahsa Ranjbar, Michael A Rotondi, Chris I Ardern, Jennifer L Kuk. Urinary Biomarkers of Polycyclic Aromatic Hydrocarbons Are Associated with Cardiometabolic Health Risk. PloS one. 2015; 10(9):e0137536. doi: 10.1371/journal.pone.0137536. [PMID: 26340343]
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  • Damien Lorenzi, Jane Entwistle, Mark Cave, Joanna Wragg, John R Dean. The application of an in vitro gastrointestinal extraction to assess the oral bioaccessibility of polycyclic aromatic hydrocarbons in soils from a former industrial site. Analytica chimica acta. 2012 Jul; 735(?):54-61. doi: 10.1016/j.aca.2012.05.030. [PMID: 22713917]
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  • Palanisami Thavamani, Mallavarapu Megharaj, Ravi Naidu. Multivariate analysis of mixed contaminants (PAHs and heavy metals) at manufactured gas plant site soils. Environmental monitoring and assessment. 2012 Jun; 184(6):3875-85. doi: 10.1007/s10661-011-2230-4. [PMID: 21789533]
  • Zin-Sig Kim, Sang Chul Lim, Seong Hyun Kim, Yong Suk Yang, Do-Hoon Hwang. Biotin-functionalized semiconducting polymer in an organic field effect transistor and application as a biosensor. Sensors (Basel, Switzerland). 2012; 12(8):11238-48. doi: 10.3390/s120811238. [PMID: 23112654]
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