2-Thiouracil (BioDeep_00000003016)

 

Secondary id: BioDeep_00001867677

human metabolite blood metabolite


代谢物信息卡片


2-Thioxo-2,3-dihydro-1H-pyrimidin-4-one

化学式: C4H4N2OS (128.0044)
中文名称: 2-硫脲嘧啶, 2-硫尿嘧啶
谱图信息: 最多检出来源 Homo sapiens(blood) 15.41%

分子结构信息

SMILES: C1=CNC(=S)NC1=O
InChI: InChI=1S/C4H4N2OS/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)

描述信息

CONFIDENCE standard compound; INTERNAL_ID 761; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 819; ORIGINAL_PRECURSOR_SCAN_NO 817
CONFIDENCE standard compound; INTERNAL_ID 761; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 814; ORIGINAL_PRECURSOR_SCAN_NO 812
CONFIDENCE standard compound; INTERNAL_ID 761; DATASET 20200303_ENTACT_RP_MIX500; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 803; ORIGINAL_PRECURSOR_SCAN_NO 801
CONFIDENCE standard compound; INTERNAL_ID 761; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 815; ORIGINAL_PRECURSOR_SCAN_NO 813
CONFIDENCE standard compound; INTERNAL_ID 761; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 831; ORIGINAL_PRECURSOR_SCAN_NO 828
CONFIDENCE standard compound; INTERNAL_ID 761; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 817; ORIGINAL_PRECURSOR_SCAN_NO 815
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D013956 - Antithyroid Agents
C471 - Enzyme Inhibitor > C29574 - Nitric Oxide Synthase Inhibitor
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
2-Thiouracil (Thiouracil) is an antithyroid compound. 2-Thiouracil can function as a highly specific melanoma seeker. 2-Thiouracil is a selective inhibitor of neuronal nitric oxide synthase (nNOS) with a Ki of 20 μM[1][2].

同义名列表

10 个代谢物同义名

2-Thioxo-2,3-dihydro-1H-pyrimidin-4-one; 2-Thio-2,4-(1H,3H)-pyrimidinedione; 4-Hydroxy-2-pyrimidinethiol; 2-Mercapto-pyrimidin-4-ol; 2-sulfanylpyrimidin-4-ol; 2-Mercapto-4-pyrimidinol; 2-thiouracil; thiouracil; Thiouracil; 2-Thiouracil



数据库引用编号

27 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ALB, CASP3, CASP8, CAT, HDAC1, HDAC4, PRL, TYR, VEGFA
Peripheral membrane protein 2 ACHE, CYP1B1
Endoplasmic reticulum membrane 1 CYP1B1
Nucleus 10 ACHE, ALB, CASP3, CASP8, HDAC1, HDAC4, KDR, MPO, PRL, VEGFA
cytosol 6 ALB, CASP3, CASP8, CAT, HDAC1, HDAC4
dendrite 1 MAOB
centrosome 1 ALB
nucleoplasm 7 ATP2B1, CASP3, CASP8, HDAC1, HDAC4, MPO, PRL
RNA polymerase II transcription regulator complex 1 PRL
Cell membrane 4 ACHE, ATP2B1, KDR, TSHR
Cytoplasmic side 1 MAOB
lamellipodium 1 CASP8
Multi-pass membrane protein 2 ATP2B1, TSHR
Synapse 3 ACHE, ATP2B1, CRH
cell junction 1 KDR
cell surface 3 ACHE, TSHR, VEGFA
glutamatergic synapse 2 ATP2B1, CASP3
Golgi apparatus 4 ACHE, ALB, KDR, VEGFA
Golgi membrane 1 INS
neuromuscular junction 2 ACHE, HDAC4
neuronal cell body 3 CASP3, HDAC1, MAOB
presynaptic membrane 1 ATP2B1
Lysosome 2 MPO, TYR
endosome 1 KDR
plasma membrane 4 ACHE, ATP2B1, KDR, TSHR
synaptic vesicle membrane 1 ATP2B1
Membrane 6 ACHE, ATP2B1, CAT, CYP1B1, TSHR, VEGFA
basolateral plasma membrane 2 ATP2B1, TSHR
extracellular exosome 4 ALB, ATP2B1, CAT, MPO
endoplasmic reticulum 3 ALB, KDR, VEGFA
extracellular space 8 ACHE, ALB, CRH, INS, MPO, PRL, TG, VEGFA
perinuclear region of cytoplasm 2 ACHE, TYR
adherens junction 1 VEGFA
mitochondrion 4 CASP8, CAT, CYP1B1, MAOB
protein-containing complex 4 ALB, CASP8, CAT, HDAC1
intracellular membrane-bounded organelle 5 ATP2B1, CAT, CYP1B1, MPO, TYR
Microsome membrane 1 CYP1B1
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 TYR
Secreted 8 ACHE, ALB, CRH, INS, PRL, TG, TRH, VEGFA
extracellular region 11 ACHE, ALB, CAT, CRH, INS, KDR, MPO, PRL, TG, TRH, VEGFA
Mitochondrion outer membrane 1 MAOB
mitochondrial outer membrane 2 CASP8, MAOB
[Isoform 2]: Secreted 1 KDR
mitochondrial matrix 1 CAT
Extracellular side 1 ACHE
anchoring junction 2 ALB, KDR
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
external side of plasma membrane 1 KDR
varicosity 1 CRH
Secreted, extracellular space, extracellular matrix 1 VEGFA
neuronal dense core vesicle lumen 1 CRH
perikaryon 1 CRH
Melanosome membrane 1 TYR
Early endosome 1 KDR
Golgi-associated vesicle 1 TYR
Cell projection, lamellipodium 1 CASP8
heterochromatin 1 HDAC1
Membrane raft 1 KDR
focal adhesion 1 CAT
extracellular matrix 1 VEGFA
Peroxisome 1 CAT
basement membrane 1 ACHE
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
secretory granule 3 MPO, TRH, VEGFA
lateral plasma membrane 2 ATP2B1, TSHR
nuclear speck 1 HDAC4
actomyosin 1 HDAC4
receptor complex 2 KDR, TSHR
ciliary basal body 1 ALB
chromatin 3 HDAC1, HDAC4, PRL
cell projection 1 ATP2B1
cytoskeleton 1 CASP8
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
Basolateral cell membrane 2 ATP2B1, TSHR
Lipid-anchor, GPI-anchor 1 ACHE
endosome lumen 2 INS, PRL
sorting endosome 1 KDR
Melanosome 1 TYR
Presynaptic cell membrane 1 ATP2B1
cell body 1 CASP8
side of membrane 1 ACHE
azurophil granule 1 MPO
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 ALB, INS
transcription repressor complex 2 HDAC1, HDAC4
platelet alpha granule lumen 2 ALB, VEGFA
histone deacetylase complex 2 HDAC1, HDAC4
transport vesicle 1 INS
azurophil granule lumen 1 MPO
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
NuRD complex 1 HDAC1
mitochondrial envelope 1 MAOB
immunological synapse 1 ATP2B1
Single-pass type IV membrane protein 1 MAOB
phagocytic vesicle lumen 1 MPO
synaptic cleft 1 ACHE
Sin3-type complex 1 HDAC1
CD95 death-inducing signaling complex 1 CASP8
death-inducing signaling complex 2 CASP3, CASP8
ripoptosome 1 CASP8
catalase complex 1 CAT
photoreceptor ribbon synapse 1 ATP2B1
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Isoform H]: Cell membrane 1 ACHE
ciliary transition fiber 1 ALB


文献列表

  • Suhad Sami Humadi, Samir Mohamed Awad, Ahmed Abd Elkader El-Rashedy, Mohamed Fathy El-Shehry. Design, synthesis, ADME, biological evaluation and molecular dynamic studies of natural and synthetic remedy of Herpes simplex virus type-1. Pakistan journal of pharmaceutical sciences. 2022 Jul; 35(4(Special)):1181-1190. doi: . [PMID: 36218096]
  • Marco H Blokland, Frederike E van Tricht, Maria J Groot, Leendert A Van Ginkel, Saskia S Sterk. Discrimination between the exogenous and endogenous origin of thiouracil in farm animals, the final chapter?. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2021 Dec; 38(12):2077-2090. doi: 10.1080/19440049.2021.1967463. [PMID: 34477489]
  • B Woźniak, S Witek, I Matraszek-Żuchowska, B Sell, A Posyniak. The effect of diet enriched with rapeseed meal on endogenous thiouracil contents in urine of calves. Research in veterinary science. 2021 May; 136(?):192-197. doi: 10.1016/j.rvsc.2020.10.021. [PMID: 33684792]
  • Zafer Sahin, Sevde Nur Biltekin, Leyla Yurttas, Barkin Berk, Yağmur Özhan, Hande Sipahi, Zhan-Guo Gao, Kenneth A Jacobson, Şeref Demirayak. Novel cyanothiouracil and cyanothiocytosine derivatives as concentration-dependent selective inhibitors of U87MG glioblastomas: Adenosine receptor binding and potent PDE4 inhibition. European journal of medicinal chemistry. 2021 Feb; 212(?):113125. doi: 10.1016/j.ejmech.2020.113125. [PMID: 33422981]
  • Rodrigo S Correa, Larissa M Bomfim, Katia M Oliveira, Diogo R M Moreira, Milena B P Soares, Javier Ellena, Daniel P Bezerra, Alzir A Batista. Ru(II) complexes containing uracil nucleobase analogs with cytotoxicity against tumor cells. Journal of inorganic biochemistry. 2019 09; 198(?):110751. doi: 10.1016/j.jinorgbio.2019.110751. [PMID: 31220757]
  • Samir M Awad, Yasser M Zohny, Sahar A Ali, Shahenda Mahgoub, Ahmed M Said. Design, Synthesis, Molecular Modeling, and Biological Evaluation of Novel Thiouracil Derivatives as Potential Antithyroid Agents. Molecules (Basel, Switzerland). 2018 Nov; 23(11):. doi: 10.3390/molecules23112913. [PMID: 30413058]
  • Ádám Tölgyesi, Anupam Giri, Eniko Barta, Thomas J McDonald, Virender K Sharma. Determination of Thyreostats in Urine Using Supported Liquid Extraction and Mixed-Mode Cation-Exchange Solid-Phase Extraction: Screening and Confirmatory Methods. Journal of chromatographic science. 2018 Oct; 56(9):858-866. doi: 10.1093/chromsci/bmy054. [PMID: 29878072]
  • Barbara Wozniak, Iwona Matraszek-Zuchowska, Sebastian Witek, Jan Zmudzki, Andrzej Posyniak. The effect of diet enriched with rapeseed meal on endogenous thiouracil contents in urine and milk of cattle. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2018 May; 35(5):892-899. doi: 10.1080/19440049.2017.1416181. [PMID: 29279007]
  • Sebastian Witek, Barbara Wozniak, Iwona Matraszek-Zuchowska, Andrzej Posyniak. Analysis of thyreostats in bovine feces using ultra high performance liquid chromatography with tandem mass spectrometry. Journal of separation science. 2018 Mar; 41(5):1083-1090. doi: 10.1002/jssc.201701069. [PMID: 29266785]
  • Weichun Yang, Ziyi Shen, Sixian Wen, Wei Wang, Minyu Hu. Mechanisms of multiple neurotransmitters in the effects of Lycopene on brain injury induced by Hyperlipidemia. Lipids in health and disease. 2018 Feb; 17(1):13. doi: 10.1186/s12944-018-0660-5. [PMID: 29409499]
  • Lieven Van Meulebroek, Jella Wauters, Beata Pomian, Julie Vanden Bussche, Philippe Delahaut, Eric Fichant, Lynn Vanhaecke. Discovery of urinary biomarkers to discriminate between exogenous and semi-endogenous thiouracil in cattle: A parallel-like randomized design. PloS one. 2018; 13(4):e0195351. doi: 10.1371/journal.pone.0195351. [PMID: 29649241]
  • J Wauters, L Van Meulebroek, E Fichant, P Delahaut, L Vanhaecke. Discrimination between Synthetically Administered and Endogenous Thiouracil Based on Monitoring of Urine, Muscle, and Thyroid Tissue: An in Vivo Study in Young and Adult Bovines. Journal of agricultural and food chemistry. 2017 Aug; 65(30):6231-6239. doi: 10.1021/acs.jafc.7b01920. [PMID: 28692258]
  • Heather Eng, Raman Sharma, Angela Wolford, Li Di, Roger B Ruggeri, Leonard Buckbinder, Edward L Conn, Deepak K Dalvie, Amit S Kalgutkar. Species Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase Enzymes. Drug metabolism and disposition: the biological fate of chemicals. 2016 08; 44(8):1262-9. doi: 10.1124/dmd.116.070185. [PMID: 27079250]
  • Jennifer Q Dong, Manthena V Varma, Angela Wolford, Tim Ryder, Li Di, Bo Feng, Steven G Terra, Kazuko Sagawa, Amit S Kalgutkar. Pharmacokinetics and Disposition of the Thiouracil Derivative PF-06282999, an Orally Bioavailable, Irreversible Inactivator of Myeloperoxidase Enzyme, Across Animals and Humans. Drug metabolism and disposition: the biological fate of chemicals. 2016 Feb; 44(2):209-19. doi: 10.1124/dmd.115.067868. [PMID: 26608081]
  • Julie A L Kiebooms, Jella Wauters, Julie Vanden Bussche, Lynn Vanhaecke. Validation of a quantitative method using liquid chromatography coupled to multiple mass spectrometry for thiouracil in feedstuffs used in animal husbandry. Analytical and bioanalytical chemistry. 2015 Jun; 407(15):4373-84. doi: 10.1007/s00216-014-8347-x. [PMID: 25424180]
  • Jella Wauters, Julie Vanden Bussche, Bruno Le Bizec, Julie A L Kiebooms, Gaud Dervilly-Pinel, Stéphanie Prevost, Barbara Wozniak, Saskia S Sterk, Dag Grønningen, D Glenn Kennedy, Sandra Russell, Philippe Delahaut, Lynn Vanhaecke. Toward a new European threshold to discriminate illegally administered from naturally occurring thiouracil in livestock. Journal of agricultural and food chemistry. 2015 Feb; 63(5):1339-46. doi: 10.1021/jf504475f. [PMID: 25611753]
  • Julie A L Kiebooms, Jella Wauters, Julie Vanden Bussche, Kurt Houf, Paul De Vos, Stefanie Van Trappen, Ilse Cleenwerck, Lynn Vanhaecke. Thiouracil-Forming Bacteria Identified and Characterized upon Porcine In Vitro Digestion of Brassicaceae Feed. Applied and environmental microbiology. 2014 Dec; 80(23):7433-42. doi: 10.1128/aem.02370-14. [PMID: 25261511]
  • Hwa-Jung Choi, Seung-Taek Yu, Kee-In Lee, Joong-Kwon Choi, Bo-Yoon Chang, Sung-Yeon Kim, Mi-Hwa Ko, Hyun-Ok Song, Hyun Park. 6-trifluoromethyl-2-thiouracil possesses anti-Toxoplasma gondii effect in vitro and in vivo with low hepatotoxicity. Experimental parasitology. 2014 Aug; 143(?):24-9. doi: 10.1016/j.exppara.2014.05.002. [PMID: 24830752]
  • Julie A L Kiebooms, Julie Vanden Bussche, Lieselot Y Hemeryck, Veerle Fievez, Lynn Vanhaecke. Intestinal microbiota contribute to the endogenous formation of thiouracil in livestock. Journal of agricultural and food chemistry. 2012 Aug; 60(32):7769-76. doi: 10.1021/jf3017145. [PMID: 22834937]
  • Boobalan Raja, Murugesan Saravanakumar, Gopal Sathya. Veratric acid ameliorates hyperlipidemia and oxidative stress in Wistar rats fed an atherogenic diet. Molecular and cellular biochemistry. 2012 Jul; 366(1-2):21-30. doi: 10.1007/s11010-012-1278-y. [PMID: 22426778]
  • Raj Kumar Bera, Anakuthil Anoop, C Retna Raj. Enzyme-free colorimetric assay of serum uric acid. Chemical communications (Cambridge, England). 2011 Nov; 47(41):11498-500. doi: 10.1039/c1cc13349g. [PMID: 21935519]
  • Yan Li, Ji-an Chen, Qing Zhao, Chaowen Pu, Zhiqun Qiu, Renping Zhang, Weiqun Shu. A cross-sectional investigation of chronic exposure to microcystin in relationship to childhood liver damage in the Three Gorges Reservoir Region, China. Environmental health perspectives. 2011 Oct; 119(10):1483-8. doi: 10.1289/ehp.1002412. [PMID: 21561830]
  • Barbara Wozniak, Iwona Matraszek Zuchowska, Jan Zmudzki, Piotr Jedziniak, Beata Korycinska, Katarzyna Sielska, Sebastian Witek, Alicja Klopot. Liquid chromatography tandem mass spectrometry with ion trap and triple quadrupole analyzers for determination of thyreostatic drugs in urine and muscle tissue. Analytica chimica acta. 2011 Aug; 700(1-2):155-66. doi: 10.1016/j.aca.2011.02.021. [PMID: 21742128]
  • Apoorva Sethi, Hamendra S Parmar, Anil Kumar. The effect of aspirin on atherogenic diet-induced diabetes mellitus. Basic & clinical pharmacology & toxicology. 2011 Jun; 108(6):371-7. doi: 10.1111/j.1742-7843.2010.00663.x. [PMID: 21205219]
  • Julie Vanden Bussche, Julie A L Kiebooms, Nathalie De Clercq, Yoann Deceuninck, Bruno Le Bizec, Hubert F De Brabander, Lynn Vanhaecke. Feed or food responsible for the presence of low-level thiouracil in urine of livestock and humans?. Journal of agricultural and food chemistry. 2011 May; 59(10):5786-92. doi: 10.1021/jf200556x. [PMID: 21504236]
  • J Vanden Bussche, L Vanhaecke, Y Deceuninck, K Wille, K Bekaert, B Le Bizec, H F De Brabander. Ultra-high performance liquid chromatography coupled to triple quadrupole mass spectrometry detection of naturally occurring thiouracil in urine of untreated livestock, domesticated animals and humans. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2011 Feb; 28(2):166-72. doi: 10.1080/19440049.2010.544681. [PMID: 21264786]
  • H I H El-Sayyad, M A El-Sherbiny, M A Sobh, A M Abou-El-Naga, M A N Ibrahim, S A Mousa. Protective effects of Morus alba leaves extract on ocular functions of pups from diabetic and hypercholesterolemic mother rats. International journal of biological sciences. 2011; 7(6):715-28. doi: 10.7150/ijbs.7.715. [PMID: 21697998]
  • Bruno Le Bizec, Emmanuelle Bichon, Yoann Deceuninck, Stéphanie Prévost, Fabrice Monteau, Jean-Philippe Antignac, Gaud Dervilly-Pinel. Toward a criterion for suspect thiouracil administration in animal husbandry. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2011; 28(7):840-7. doi: 10.1080/19440049.2011.565483. [PMID: 21547795]
  • Laura Groseanu, Rodica Marinescu, Dan Laptoiun, Iozefina Botezatu, Florica Staniceanu, Sabina Zurac, Ruxandra lonescu. A late and difficult diagnosis of ochronosis. Journal of medicine and life. 2010 Oct; 3(4):437-43. doi: NULL. [PMID: 21254745]
  • J Vanden Bussche, L Vanhaecke, Y Deceuninck, K Verheyden, K Wille, K Bekaert, B Le Bizec, H F De Brabander. Development and validation of an ultra-high performance liquid chromatography tandem mass spectrometry method for quantifying thyreostats in urine without derivatisation. Journal of chromatography. A. 2010 Jun; 1217(26):4285-93. doi: 10.1016/j.chroma.2010.04.030. [PMID: 20471019]
  • Kyohei Ago, Yukie Saegusa, Jihei Nishimura, Yasuaki Dewa, Sayaka Kemmochi, Masaomi Kawai, Tomoaki Harada, Kunitoshi Mitsumori, Makoto Shibutani. Involvement of glycogen synthase kinase-3beta signaling and aberrant nucleocytoplasmic localization of retinoblastoma protein in tumor promotion in a rat two-stage thyroid carcinogenesis model. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 2010 May; 62(3):269-80. doi: 10.1016/j.etp.2009.04.003. [PMID: 19505811]
  • Margarita S Chernov'yants, Andrey O Dolinkin, Anatoly V Chernyshev, Evgeniy V Khohlov, Elizaveta G Golovanova. Interaction of antithyroid drugs with bovine serum albumin: electrophoretic and fluorimetric study. Journal of pharmaceutical sciences. 2010 Mar; 99(3):1567-73. doi: 10.1002/jps.21915. [PMID: 19774650]
  • Krishna P Bhabak, Govindasamy Mugesh. Antithyroid drugs and their analogues protect against peroxynitrite-mediated protein tyrosine nitration--a mechanistic study. Chemistry (Weinheim an der Bergstrasse, Germany). 2010 Jan; 16(4):1175-85. doi: 10.1002/chem.200902145. [PMID: 20029917]
  • Arijit Das, Hyojin Ko, Lauren E Burianek, Matthew O Barrett, T Kendall Harden, Kenneth A Jacobson. Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups. Journal of medicinal chemistry. 2010 Jan; 53(1):471-80. doi: 10.1021/jm901432g. [PMID: 19902968]
  • Madis Lõhmus, Kalle Kallaste, Bruno Le Bizec. Determination of thyreostats in urine and thyroid gland by ultra high performance liquid chromatography tandem mass spectrometry. Journal of chromatography. A. 2009 Nov; 1216(46):8080-9. doi: 10.1016/j.chroma.2009.04.005. [PMID: 19406410]
  • Dharmendra Sharma, Chandra Mohini Chaturvedi. Effects of thyroid status on arginine vasotocin receptor VT2R expression and adrenal function in osmotically stimulated domestic fowl. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. 2009 Oct; 179(7):811-9. doi: 10.1007/s00360-009-0362-4. [PMID: 19381646]
  • Eva D McLanahan, Melvin E Andersen, Jerry L Campbell, Jeffrey W Fisher. Competitive inhibition of thyroidal uptake of dietary iodide by perchlorate does not describe perturbations in rat serum total T4 and TSH. Environmental health perspectives. 2009 May; 117(5):731-8. doi: 10.1289/ehp.0800111. [PMID: 19479014]
  • Kenneth A Jacobson, Andrei A Ivanov, Sonia de Castro, T Kendall Harden, Hyojin Ko. Development of selective agonists and antagonists of P2Y receptors. Purinergic signalling. 2009 Mar; 5(1):75-89. doi: 10.1007/s11302-008-9106-2. [PMID: 18600475]
  • Manickam Akila, Halagowder Devaraj. Synergistic effect of tincture of Crataegus and Mangifera indica L. extract on hyperlipidemic and antioxidant status in atherogenic rats. Vascular pharmacology. 2008 Oct; 49(4-6):173-7. doi: 10.1016/j.vph.2008.07.007. [PMID: 18755296]
  • Erdinç Devrim, Imge B Ergüder, Hanefi Ozbek, Ilker Durak. High-cholesterol diet increases xanthine oxidase and decreases nitric oxide synthase activities in erythrocytes from rats. Nutrition research (New York, N.Y.). 2008 Mar; 28(3):212-5. doi: 10.1016/j.nutres.2008.01.006. [PMID: 19083410]
  • Hamendra Singh Parmar, Anand Kar. Possible amelioration of atherogenic diet induced dyslipidemia, hypothyroidism and hyperglycemia by the peel extracts of Mangifera indica, Cucumis melo and Citrullus vulgaris fruits in rats. BioFactors (Oxford, England). 2008; 33(1):13-24. doi: 10.1002/biof.5520330102. [PMID: 19276533]
  • Hamendra Singh Parmar, Anand Kar. Atherogenic diet induced diabetes mellitus: involvement of thyroid hormones. European journal of pharmacology. 2007 Sep; 570(1-3):244-8. doi: 10.1016/j.ejphar.2007.06.020. [PMID: 17628531]
  • Fernanda S Gravina, Clarice K B da Silveira, Adriano M de Assis, Débora K Rieger, Carolina Guerini, Alexandre P Müller, Marcelo Farina, Liane N Rotta, Marcos L S Perry. Experimental hypothyroidism inhibits delta-aminolevulinate dehydratase activity in neonatal rat blood and liver. Experimental biology and medicine (Maywood, N.J.). 2007 Sep; 232(8):1021-6. doi: 10.3181/0703-rm-66. [PMID: 17720948]
  • Mongia Hachicha, Thouraya Kammoun, Wafa Ben Romdhane, Rim Ben Abdallah, Abdelmajid Mahfoudh, Khaoula Kammoun, Jamil Hachicha, Ali Triki. [Vasculitis with renal involvement and antineutrophil cytoplasmic antibodies (ANCA) in a child receiving benzylthiouracil]. Nephrologie & therapeutique. 2007 Jul; 3(4):147-51. doi: 10.1016/j.nephro.2007.04.001. [PMID: 17658441]
  • Hyojin Ko, Ingrid Fricks, Andrei A Ivanov, T Kendall Harden, Kenneth A Jacobson. Structure-activity relationship of uridine 5'-diphosphoglucose analogues as agonists of the human P2Y14 receptor. Journal of medicinal chemistry. 2007 May; 50(9):2030-9. doi: 10.1021/jm061222w. [PMID: 17407275]
  • Mahfoud Messarah, Mohamed Salah Boulakoud, Amel Boumendjel, Cherif Abdennour, Abdelfattah El Feki. The impact of thyroid activity variations on some oxidizing-stress parameters in rats. Comptes rendus biologies. 2007 Feb; 330(2):107-12. doi: 10.1016/j.crvi.2006.11.004. [PMID: 17303537]
  • G Pinel, S Mathieu, N Cesbron, D Maume, H F De Brabander, F Andre, B Le Bizec. Evidence that urinary excretion of thiouracil in adult bovine submitted to a cruciferous diet can give erroneous indications of the possible illegal use of thyrostats in meat production. Food additives and contaminants. 2006 Oct; 23(10):974-80. doi: 10.1080/02652030600806370. [PMID: 16982518]
  • Gaud Pinel, Daniel Maume, Yoann Deceuninck, François Andre, Bruno Le Bizec. Unambiguous identification of thiouracil residue in urine collected in non-treated bovine by tandem and high-resolution mass spectrometry. Rapid communications in mass spectrometry : RCM. 2006; 20(21):3183-7. doi: 10.1002/rcm.2711. [PMID: 17019670]
  • Omar N Al Safarjalani, Xiao-Jian Zhou, Reem H Rais, Junxing Shi, Raymond F Schinazi, Fardos N M Naguib, Mahmoud H El Kouni. 5-(Phenylthio)acyclouridine: a powerful enhancer of oral uridine bioavailability: relevance to chemotherapy with 5-fluorouracil and other uridine rescue regimens. Cancer chemotherapy and pharmacology. 2005 Jun; 55(6):541-51. doi: 10.1007/s00280-004-0967-y. [PMID: 15729584]
  • Tomás Pérez-Ruiz, Carmen Martínez-Lozano, Antonio Sanz, Raquel Galera. An ultrasensitive method for the determination of thiouracil and phenylthiouracil using capillary zone electrophoresis and laser-induced fluorescence detection. Electrophoresis. 2005 Jun; 26(12):2384-90. doi: 10.1002/elps.200410252. [PMID: 15895465]
  • P R Deepa, P Varalakshmi. Atheroprotective effect of exogenous heparin-derivative treatment on the aortic disturbances and lipoprotein oxidation in hypercholesterolemic diet fed rats. Clinica chimica acta; international journal of clinical chemistry. 2005 May; 355(1-2):119-30. doi: 10.1016/j.cccn.2004.12.007. [PMID: 15820486]
  • Erina Saita, Atsushi Tohei, Wan Zhu Jin, Shinji Takahashi, Akira K Suzuki, Gen Watanabe, Kazuyoshi Taya. Effects of hypothyroidism on gonadal function after transition of short day photoperiod in male golden hamsters (Mesocricetus auratus). The Journal of reproduction and development. 2005 Apr; 51(2):221-8. doi: 10.1262/jrd.16057. [PMID: 15699585]
  • Amel Braham, Med Habib Houman, Lamia Rais, Imed Ben Gborbel, Mounir Lamloum, Mohamed Miled. [Benzylthiouracil induced ANCA-positive vasculitis]. Presse medicale (Paris, France : 1983). 2004 Nov; 33(19 Pt 1):1331-3. doi: 10.1016/s0755-4982(04)98919-1. [PMID: 15615240]
  • Catherine Bovie, Marc Ongena, Philippe Thonart, Jacques Dommes. Cloning and expression analysis of cDNAs corresponding to genes activated in cucumber showing systemic acquired resistance after BTH treatment. BMC plant biology. 2004 Aug; 4(?):15. doi: 10.1186/1471-2229-4-15. [PMID: 15331019]
  • Perinkulam Ravi Deepa, Palaninathan Varalakshmi. Protective effects of certoparin sodium, a low molecular weight heparin derivative, in experimental atherosclerosis. Clinica chimica acta; international journal of clinical chemistry. 2004 Jan; 339(1-2):105-15. doi: 10.1016/j.cccn.2003.09.021. [PMID: 14687900]
  • P R Deepa, P Varalakshmi. Salubrious effect of low molecular weight heparin on atherogenic diet-induced cardiac, hepatic and renal lipid peroxidation and collapse of antioxidant defences. Molecular and cellular biochemistry. 2003 Dec; 254(1-2):111-6. doi: 10.1023/a:1027324318973. [PMID: 14674688]
  • P R Deepa, P Varalakshmi. Favourable influence of low molecular weight heparin in mitigating the peroxidative membrane damage induced by a cytotoxic agent and an atherogenic diet. Human & experimental toxicology. 2003 May; 22(5):229-35. doi: 10.1191/0960327103ht348oa. [PMID: 12774884]
  • Robert Zakrzewski, Witold Ciesielski. Application of improved iodine-azide procedure for the detection of thiouracils in blood serum and urine with planar chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2003 Feb; 784(2):283-90. doi: 10.1016/s1570-0232(02)00806-1. [PMID: 12505776]
  • H Kaaroud, K Khiari, F Ben Moussa, S Barbouch, E Boussema, H Ben Maïz. [Vasculitis with renal and pulmonary involvement in a patient receiving benzylthiouracil for Graves disease]. La Revue de medecine interne. 2002 Oct; 23(10):857-61. doi: 10.1016/s0248-8663(02)00704-x. [PMID: 12428490]
  • O N Al Safarjalani, X J Zhou, F N Naguib, J Shi, R F Schinazi, M H el Kouni. Enhancement of the bioavailability of oral uridine by coadministration of 5-(phenylthio)acyclouridine, a uridine phosphorylase inhibitor: implications for uridine rescue regimens in chemotherapy. Cancer chemotherapy and pharmacology. 2001 Nov; 48(5):389-97. doi: 10.1007/s002800100353. [PMID: 11761457]
  • J A Del Compare, J A Aguirre, F R Ibarra, M Barontini, I Armando. Effects of thyroid hormone on the renal dopaminergic system. Endocrine. 2001 Aug; 15(3):297-303. doi: 10.1385/endo:15:3:297. [PMID: 11762703]
  • O N Al Safarjalani, X J Zhou, F N Naguib, N M Goudgaon, R F Schinazi, M H el Kouni. Modulation of the pharmacokinetics of endogenous plasma uridine by 5-(phenylthio)acyclouridine, a uridine phosphorylase inhibitor: implications for chemotherapy. Cancer chemotherapy and pharmacology. 2001 Aug; 48(2):145-50. doi: 10.1007/s002800100292. [PMID: 11565561]
  • V U Buko, O Lukivskaya, E Naruta, Y Popov, A Chirkin, I Chirkina, M Oettel, W Römer, D Hübler. Antiatherogenic effects of 17 beta-estradiol and 17 alpha-estradiol and its derivative J811 in cholesterol-fed rabbits with thyroid inhibition. Climacteric : the journal of the International Menopause Society. 2001 Mar; 4(1):49-57. doi: 10.1080/cmt.4.1.49.57. [PMID: 11379378]
  • U Mårs, V Tolmachev, A Sundin. Positron emission tomography of experimental melanoma with. Nuclear medicine and biology. 2000 Nov; 27(8):845-9. doi: 10.1016/s0969-8051(00)00147-5. [PMID: 11150719]
  • A Tohei, K Taya, G Watanabe, J L Voogt. Hypothyroidism increases prolactin secretion and decreases the intromission threshold for induction of pseudopregnancy in adult female rats. Physiology & behavior. 2000 Jun; 69(4-5):391-7. doi: 10.1016/s0031-9384(00)00224-9. [PMID: 10913776]
  • A M Zatón, J P Villamor. Study of heterocycle rings binding to human serum albumin. Chemico-biological interactions. 2000 Jan; 124(1):1-11. doi: 10.1016/s0009-2797(99)00130-1. [PMID: 10658898]
  • P Mackowiak, E Ginalska, E Nowak-Strojec, T Szkudelski. The influence of hypo- and hyperthyreosis on insulin receptors and metabolism. Archives of physiology and biochemistry. 1999 Oct; 107(4):273-9. doi: 10.1076/13813455199908107041qft273. [PMID: 10779823]
  • I Roman, R Giurgea. Thyroxin and thiouracyl influence upon some biochemical parameters in chicken thymuses. Romanian journal of physiology : physiological sciences. 1999 Jan; 36(1-2):97-101. doi: NULL. [PMID: 11068610]
  • A Tohei, G Watanabe, K Taya. Effects of thyroidectomy or thiouracil treatment on copulatory behavior in adult male rats. The Journal of veterinary medical science. 1998 Mar; 60(3):281-5. doi: 10.1292/jvms.60.281. [PMID: 9560772]
  • A Tohei, G Watanabe, K Taya. Hypersecretion of corticotrophin-releasing hormone and arginine vasopressin in hypothyroid male rats as estimated with push-pull perfusion. The Journal of endocrinology. 1998 Feb; 156(2):395-400. doi: 10.1677/joe.0.1560395. [PMID: 9518888]
  • G Vargas, J Havel, K Frgalová. Capillary zone electrophoresis determination of thyreostatic drugs in urine. Journal of capillary electrophoresis. 1998 Jan; 5(1-2):9-12. doi: NULL. [PMID: 10327364]
  • E Ochoa de Aspuru, M A Marquínez, A M Zatón. Protein dilution effect on thiouracil-seroalbumin interactions. Biophysical chemistry. 1997 Dec; 69(2-3):233-7. doi: 10.1016/s0301-4622(97)00094-x. [PMID: 9474756]
  • G Viglietto, A Romano, G Manzo, G Chiappetta, I Paoletti, D Califano, M G Galati, V Mauriello, P Bruni, C T Lago, A Fusco, M G Persico. Upregulation of the angiogenic factors PlGF, VEGF and their receptors (Flt-1, Flk-1/KDR) by TSH in cultured thyrocytes and in the thyroid gland of thiouracil-fed rats suggest a TSH-dependent paracrine mechanism for goiter hypervascularization. Oncogene. 1997 Nov; 15(22):2687-98. doi: 10.1038/sj.onc.1201456. [PMID: 9400995]
  • E D Peebles, E H Miller, C R Boyle, J D Brake, M A Latour, J P Thaxton. Effects of consecutive thiouracil exposures in the juvenile and adult single comb White Leghorn chicken on body weight and reproductive performance. Poultry science. 1997 Feb; 76(2):236-43. doi: 10.1093/ps/76.2.236. [PMID: 9057201]
  • L Krivánková, S Krásenský, P Bocek. Application of capillary zone electrophoresis for analysis of thyreostatics. Electrophoresis. 1996 Dec; 17(12):1959-63. doi: 10.1002/elps.1150171226. [PMID: 9034783]
  • I E Veronikis, S Alex, S L Fang, G Wright, S Y Wu, J P Chanoine, C H Emerson, L E Braverman. Serum iodothyronine concentrations in intestinally decontaminated rats treated with a 5'-deiodinase type I inhibitor 6-anilino-2-thiouracil. European journal of endocrinology. 1996 Apr; 134(4):519-23. doi: 10.1530/eje.0.1340519. [PMID: 8640307]
  • K Sato, K Yamazaki, K Shizume, Y Kanaji, T Obara, K Ohsumi, H Demura, S Yamaguchi, M Shibuya. Stimulation by thyroid-stimulating hormone and Grave's immunoglobulin G of vascular endothelial growth factor mRNA expression in human thyroid follicles in vitro and flt mRNA expression in the rat thyroid in vivo. The Journal of clinical investigation. 1995 Sep; 96(3):1295-302. doi: 10.1172/jci118164. [PMID: 7657804]
  • T Y Chan, P L Tang. Effect of melatonin on the maintenance of cholesterol homeostasis in the rat. Endocrine research. 1995 Aug; 21(3):681-96. doi: 10.1080/07435809509030483. [PMID: 7588436]
  • E D Peebles, E H Miller, C R Boyle, J D Brake, M A Latour. Effects of dietary thiouracil on thyroid activity, egg production, and eggshell quality in commercial layers. Poultry science. 1994 Dec; 73(12):1829-37. doi: 10.3382/ps.0731829. [PMID: 7877939]
  • I M Colin, P L Selvais, T Rebai, D M Maiter, E Adam, M F vandenHove, J M Ketelslegers, J F Denef. Expression of the endothelin-1 gene in the rat thyroid gland and changes in its peptide and mRNA levels in goiter formation and iodide-induced involution. The Journal of endocrinology. 1994 Oct; 143(1):65-74. doi: 10.1677/joe.0.1430065. [PMID: 7964323]
  • R Verrijk, I J Smolders, R Huiskamp, P R Gavin, K H Philipp, A C Begg. Pharmacokinetics in melanoma-bearing mice of 5-dihydroxyboryl-6-propyl-2-thiouracil (BPTU), a candidate compound for boron neutron capture therapy. British journal of cancer. 1994 Apr; 69(4):641-7. doi: 10.1038/bjc.1994.125. [PMID: 8142252]
  • T Padró, C M van den Hoogen, J J Emeis. Experimental hypothyroidism increases plasminogen activator inhibitor activity in rat plasma. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. 1993 Oct; 4(5):797-800. doi: 10.1097/00001721-199304050-00018. [PMID: 8292731]
  • G Imokawa, I Motegi. Skin organ culture model for examining epidermal melanization. The Journal of investigative dermatology. 1993 Jan; 100(1):47-54. doi: 10.1111/1523-1747.ep12354117. [PMID: 8423395]
  • J J Nunnari, M Fisher, S D White. Inhibition of lipid deposition in the hypercholesterolemic rat by clentiazem, a calcium channel blocker. Experimental and molecular pathology. 1992 Dec; 57(3):193-204. doi: 10.1016/0014-4800(92)90010-9. [PMID: 1286670]
  • E D Peebles, E H Miller, J D Brake, C D Schultz. Effects of ascorbic acid on plasma thyroxine concentrations and eggshell quality of Leghorn chickens treated with dietary thiouracil. Poultry science. 1992 Mar; 71(3):553-9. doi: 10.3382/ps.0710553. [PMID: 1561222]
  • K Olander, B S Larsson, U Ringborg, P O Schnell. Uptake of [131I]thiouracil in tumours of patients with disseminated malignant melanoma. A pilot study. Melanoma research. 1992 Jan; 1(5-6):391-5. doi: 10.1097/00008390-199201000-00011. [PMID: 1422195]
  • K Hannon, A Trenkle. Relationship of thyroid status to growth hormone and insulin-like growth factor-I (IGF-I) in plasma and IGF-I mRNA in liver and skeletal muscle of cattle. Domestic animal endocrinology. 1991 Oct; 8(4):595-600. doi: 10.1016/0739-7240(91)90029-j. [PMID: 1786706]
  • V L Christensen, W E Donaldson, J F Ort, J L Grimes. Influence of diet-mediated maternal thyroid alterations on hatchability and metabolism of turkey embryos. Poultry science. 1991 Jul; 70(7):1594-601. doi: 10.3382/ps.0701594. [PMID: 1653423]
  • E D Peebles, H L Marks. Effects of selection on plasma thyroxine concentrations in Japanese quail under thiouracil and protein stress. Poultry science. 1991 Mar; 70(3):641-50. doi: 10.3382/ps.0700641. [PMID: 2047354]
  • K Yagasaki, R Funabiki. Effects of dietary supplemented amino acids on endogenous hypercholesterolemia in rats. Journal of nutritional science and vitaminology. 1990 Oct; 36 Suppl 2(?):S165-8. doi: 10.3177/jnsv.36.supplementii_s165. [PMID: 2130151]
  • R Schilt, J M Weseman, H Hooijerink, H J Korbee, W A Traag, M J van Steenbergen, W Haasnoot. Screening and confirmation of thyreostatics in urine by gas chromatography with nitrogen-phosphorus detection and gas chromatography-mass spectrometry after sample clean-up with a mercurated affinity column. Journal of chromatography. 1989 Apr; 489(1):127-37. doi: 10.1016/s0378-4347(00)82890-x. [PMID: 2745644]
  • T R Scott, B Glick. In vitro thymidine uptake and incorporation into thymic and bursal lymphocytes from young hypothyroidic chickens. International archives of allergy and applied immunology. 1989; 89(4):394-9. doi: 10.1159/000234981. [PMID: 2793225]
  • E L Stokstad, C P Nair. Effect of hypothyroidism on methylmalonate excretion and hepatic vitamin B-12 levels in rats. The Journal of nutrition. 1988 Dec; 118(12):1495-501. doi: 10.1093/jn/118.12.1495. [PMID: 3210077]
  • A Zatón, A Martinez, J Manuel de Gandarias. The binding of thioureylene compounds to human serum albumin. Biochemical pharmacology. 1988 Aug; 37(16):3127-31. doi: 10.1016/0006-2952(88)90310-3. [PMID: 2456766]
  • A Martin, F M McNabb, P B Siegel. Thiouracil and antibody titers of chickens from lines divergently selected for antibody response to sheep erythrocytes. Developmental and comparative immunology. 1988; 12(3):611-9. doi: 10.1016/0145-305x(88)90077-8. [PMID: 3169356]
  • T Scott, B Glick. Organ weights, T-cell proliferation, and graft vs host capabilities of hypothyroidic chickens. General and comparative endocrinology. 1987 Aug; 67(2):270-6. doi: 10.1016/0016-6480(87)90157-2. [PMID: 3497840]
  • K G Vanscoik, C A Johnson, W R Porter. Sensitive and specific high-performance liquid chromatographic assay for 6-thiouric acid. Journal of chromatography. 1987 Jun; 417(1):183-9. doi: 10.1016/0378-4347(87)80106-8. [PMID: 3624395]
  • G Schuster, C Arenhövel, E Golovinsky. Analogues of pyrimidine base precursors as antiphytoviral agents. Antiviral research. 1987 Mar; 7(3):179-84. doi: 10.1016/0166-3542(87)90006-4. [PMID: 3606085]
  • J W Oliver, D S Sachan, P Su, F M Applehans. Effects of zinc deficiency on thyroid function. Drug-nutrient interactions. 1987; 5(2):113-24. doi: NULL. [PMID: 3608829]