Ginsenoside A2 (BioDeep_00000000003)

human metabolite PANOMIX_OTCML-2023 Endogenous

代谢物信息卡片

化学式: C42H72O14 (800.4921812)
中文名称: 人参皂苷, 人参皂苷 Rg1, 人参皂甙 Rg1
谱图信息: 最多检出来源 Viridiplantae(plant) 17.33%

分子结构信息

SMILES: C1C[C@H](O)C(C)(C)[C@]2([H])[C@@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)C[C@@]3(C)[C@]4(C)CC[C@@]([C@](O[C@H]5[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O5)(C)CC/C=C(\C)/C)([H])[C@@]4([H])[C@H](O)C[C@]3([H])[C@@]12C
InChI: InChI=1S/C42H72O14/c1-20(2)10-9-13-42(8,56-37-34(52)32(50)30(48)25(19-44)55-37)21-11-15-40(6)28(21)22(45)16-26-39(5)14-12-27(46)38(3,4)35(39)23(17-41(26,40)7)53-36-33(51)31(49)29(47)24(18-43)54-36/h10,21-37,43-52H,9,11-19H2,1-8H3

描述信息

Ginsenoside Rg1 is a ginsenoside found in Panax ginseng and Panax japonicus var. major that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 6 and 20 have been converted to the corresponding beta-D-glucopyranosides, and in which a double bond has been introduced at the 24-25 position. It has a role as a neuroprotective agent and a pro-angiogenic agent. It is a 12beta-hydroxy steroid, a beta-D-glucoside, a tetracyclic triterpenoid, a ginsenoside and a 3beta-hydroxy-4,4-dimethylsteroid. It derives from a hydride of a dammarane.
Ginsenosides are a class of steroid glycosides, and triterpene saponins, found exclusively in the plant genus Panax (ginseng). Ginsenosides have been the target of research, as they are viewed as the active compounds behind the claims of ginsengs efficacy. Because ginsenosides appear to affect multiple pathways, their effects are complex and difficult to isolate. Rg1 Appears to be most abundant in Panax ginseng (Chinese/Korean Ginseng). It improves spatial learning and increase hippocampal synaptophysin level in mice, plus demonstrates estrogen-like activity.
Ginsenoside RG1 is a natural product found in Panax vietnamensis, Panax ginseng, and Panax notoginseng with data available.
See also: Asian Ginseng (part of); American Ginseng (part of); Panax notoginseng root (part of).
Ginsenoside A2 is found in tea. Ginsenoside A2 is a constituent of Panax ginseng (ginseng)
Constituent of Panax ginseng (ginseng). Ginsenoside A2 is found in tea.
D002491 - Central Nervous System Agents
Ginsenoside Rg1 is one of the major active components of Panax ginseng. Ginsenoside Rg1 ameliorates the impaired cognitive function, displays promising effects by reducing cerebral Aβ levels. Ginsenoside Rg1 also reduces NF-κB nuclear translocation.
Ginsenoside Rg1 is one of the major active components of Panax ginseng. Ginsenoside Rg1 ameliorates the impaired cognitive function, displays promising effects by reducing cerebral Aβ levels. Ginsenoside Rg1 also reduces NF-κB nuclear translocation.

同义名列表

43 个代谢物同义名

(2R,3R,4S,5S,6R)-2-(((3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-4,4,8,10,14-pentamethyl-17-((S)-6-methyl-2-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hept-5-en-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-6-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol; 2-{[2-(5,16-dihydroxy-2,6,6,10,11-pentamethyl-8-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-14-yl)-6-methylhept-5-en-2-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol; (3beta,alpha,12beta)-20-(beta-D-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl beta-D-glucopyranoside; .BETA.-D-GLUCOPYRANOSIDE, (3.BETA.,6.ALPHA.,12.BETA.)-3,12- DIHYDROXY DAMMAR-24-ENE-6,20-DIYLBIS-; .BETA.-D-GLUCOPYRANOSIDE, (3.BETA.,6.ALPHA.,12.BETA.)-3,12-DIHYDROXYDAMMAR-24-ENE-6,20-DIYL BIS-; (3.BETA.,6.ALPHA.,12.BETA.)-3,12-DIHYDROXYDAMMAR-24-ENE-6,20- DIYLBIS(.BETA.-D-GLUCOPYRANOSIDE); GINSENOSIDE RG1 (CONSTITUENT OF AMERICAN GINSENG, ASIAN GINSENG, AND TIENCHI GINSENG) [DSC]; beta-D-Glucopyranoside, (3beta,6alpha,12beta)-3,12-dihydroxydammar-24-ene-6,20-diyl bis-; beta-D-Glucopyranoside, (3beta,6alpha,12beta)-3,12-dihydroxy dammar-24-ene-6,20-diylbis-; (3beta,6alpha,12beta)-3,12-Dihydroxydammar-24-ene-6,20-diyl bis-beta-D-Glucopyranoside; (3beta,6alpha,12beta)-3,12-Dihydroxydammar-24-ene-6,20-diylbis(beta-D-glucopyranoside); GINSENOSIDE RG1 (CONSTITUENT OF AMERICAN GINSENG, ASIAN GINSENG, AND TIENCHI GINSENG); (6)-.BETA.-D-GLUCOPYRANOSYL-(20)-.BETA.-D-GLUCOPYRANOSYL-20S- PROTOPANAXATRIOL; 3beta,12beta-dihydroxydammar-24-ene-6alpha,20-diyl bis-beta-D-glucopyranoside; (3b,6a,12b)-3,12-dihydroxydammar-24-ene-6,20- diylbis(beta-d-glucopyranoside); (6)-beta-D-Glucopyranosyl-(20)-beta-D-glucopyranosyl-20S-protopanaxatriol; 6-(Hexopyranosyloxy)-3,12-dihydroxydammar-24-en-20-yl hexopyranoside; Ginsenoside Rg1, United States Pharmacopeia (USP) Reference Standard; Ginsenoside Rg1, primary pharmaceutical reference standard; 7-HYDROXY-2-OXO-2H-CHROMENE-3-CARBOXYLICACIDAMIDE; Ginsenoside Rg1, analytical standard; YURJSTAIMNSZAE-HHNZYBFYSA-N; Panaxoside A; GINSENOSIDE RG1 [USP-RS]; GINSENOSIDE RG1 (USP-RS); GINSENOSIDE RG1 [WHO-DD]; (20S)-ginsenoside Rg1; sanchinoside C(1); ginsenoside-Rg(1); Sanchinoside Rg1; Ginsenoside Rg1; ginsenoside-Rg1; sanchinoside C1; panaxoside Rg1; Ginsenoside A2; GinsenosideRG1; Ginsenoside g1; Panaxoside A; Ginsenoside; NSC303791; RG1; Panaxoside Rg1; Ginsenoside Rg1

数据库引用编号

23 个数据库交叉引用编号

ChEBI: CHEBI:67987
KEGG: C08946
PubChem: 441923
PubChem: 432116
HMDB: HMDB0035857
Metlin: METLIN67294
DrugBank: DB06750
ChEMBL: CHEMBL501637
LipidMAPS: LMPR0106080011
MeSH: ginsenoside Rg1
ChemIDplus: 0022427390
MetaCyc: CPD-15445
KNApSAcK: C00003520
foodb: FDB014636
chemspider: 390498
chemspider: 382150
CAS: 22427-39-0
medchemexpress: HY-N0045
PMhub: MS000010958
PubChem: 11138
3DMET: B02549
NIKKAJI: J15.784H
KNApSAcK: 67987

分类词条

代谢反应

3 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

ginsenosides biosynthesis: β-amyrin + O₂ + a reduced [NADPH-hemoprotein reductase] ⟶ H⁺ + H₂O + an oxidized [NADPH-hemoprotein reductase] + oleanolate

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(2)

ginsenosides biosynthesis: H⁺ + NADPH + O₂ + dammarenediol II ⟶ H₂O + NADP⁺ + protopanaxadiol
ginsenosides biosynthesis: (20S)-ginsenoside Rh2 + UDP-α-D-glucose ⟶ (20S)-ginsenoside Rg3 + H⁺ + UDP

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

53 个相关的物种来源信息

126358 - Abeliophyllum distichum: 10.1016/S0031-9422(97)01134-5
4217 - Arctium lappa: 10.1007/978-1-4613-1855-2_22
4217 - Arctium lappa: 10.1007/978-3-540-71095-0_1382
4217 - Arctium lappa: 10.1016/J.JPBA.2009.03.018
4217 - Arctium lappa: 10.1016/J.PHYMED.2009.04.005
4217 - Arctium lappa: 10.1016/S0031-9422(00)89550-3
4217 - Arctium lappa: 10.1248/BPB.19.1515
4217 - Arctium lappa: 10.1248/CPB.44.2300
1486496 - Centaurea arenaria: 10.1002/PTR.3187
363423 - Centaurea deflexa: 10.1016/J.EJMECH.2011.03.011
75648 - Centaurea imperialis: 10.1016/0031-9422(81)85287-9
41536 - Centaurea melitensis: 10.1016/J.PHYTOCHEM.2006.08.012
41536 - Centaurea melitensis: 10.1016/S0305-1978(01)00062-X
75633 - Centaurea nigra: 10.1016/S0305-1978(02)00227-2
145513 - Centaurea raphanina: 10.1590/S0102-695X2007000200003
363450 - Centaurea sclerolepis: 10.1177/1934578X0600100403
2753873 - Daphne feddei: 10.1021/NP8004166
205692 - Forsythia koreana: 10.1016/S0031-9422(00)83456-1
205692 - Forsythia koreana: 10.1016/S0031-9422(97)01134-5
205694 - Forsythia ovata: 10.1248/CPB.36.3667
126418 - Forsythia suspensa: 10.1002/RCM.2875
205691 - Forsythia viridissima: 10.1016/S0031-9422(00)83456-1
205691 - Forsythia viridissima: 10.1016/S0031-9422(97)01134-5
373155 - Gaillardia aestivalis: 10.1016/S0031-9422(00)95216-6
9606 - Homo sapiens: -
196747 - Onopordum acaulon: 10.1016/0031-9422(92)83742-H
297478 - Onopordum illyricum: 10.1021/NP990098Z
4054 - Panax ginseng:
4054 - Panax Ginseng C. A. Mey.: -
44685 - Panax japonicus:
44586 - Panax notoginseng:
44586 - Panax notoginseng (Burk.) F. H. Chen: -
44586 - Panax Notoginseng (Burk.) F. H. Chen Ex C. Chow: -
106132 - Panax vietnamensis: 10.1021/NP000393F
33090 - Plants: -
41506 - Plectocephalus americanus: 10.1016/J.PHYTOCHEM.2006.08.012
41506 - Plectocephalus americanus: 10.1016/S0305-1978(01)00062-X
200489 - Saussurea involucrata: 10.1080/10286020.2010.499856
254913 - Saussurea laniceps: 10.1002/HLCA.200790096
254913 - Saussurea laniceps: 10.1016/S1875-5364(11)60016-2
2893703 - Saussurea macrota: 10.1002/CHIN.200516160
137893 - Saussurea medusa: 10.1016/S0031-9422(01)00429-0
137893 - Saussurea medusa: 10.1016/S0304-3835(00)00499-7
137893 - Saussurea medusa: 10.1248/CPB.53.1416
446849 - Saussurea salicifolia: 10.1016/J.FCT.2010.05.056
50189 - Torreya nucifera: 10.1055/S-2001-15804
276781 - Trachelospermum asiaticum: 10.1016/0031-9422(72)80115-8
276781 - Trachelospermum asiaticum: 10.1248/CPB.34.4340
276781 - Trachelospermum asiaticum: 10.1248/YAKUSHI1947.93.4_539
429296 - Trachelospermum axillare: 10.1016/0031-9422(93)85183-R
947960 - Trachelospermum gracilipes: 10.1016/0031-9422(72)80115-8
69389 - Trachelospermum jasminoides: 10.1248/YAKUSHI1947.93.4_539
33090 - 西洋参: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Liangliang Kong, Yan Liu, Jingwei Li, Yanyan Wang, Pengmin Ji, Qifeng Shi, Min Han, Hanyang Xu, Weiping Li, Weizu Li. Ginsenoside Rg1 alleviates chronic inflammation-induced neuronal ferroptosis and cognitive impairments via regulation of AIM2 - Nrf2 signaling pathway. Journal of ethnopharmacology. 2024 Aug; 330(?):118205. doi: 10.1016/j.jep.2024.118205. [PMID: 38641079]
Hui Liu, Xiao-Qian Wu, Xiang-Ling Qin, Jin-Hao Zhu, Jin-Di Xu, Shan-Shan Zhou, Ming Kong, Hong Shen, Jie-Ge Huo, Song-Lin Li, He Zhu. Metals/bisulfite system involved generation of 24-sulfonic-25-ene ginsenoside Rg1, a potential quality control marker for sulfur-fumigated ginseng. Food chemistry. 2024 Aug; 448(?):139112. doi: 10.1016/j.foodchem.2024.139112. [PMID: 38569404]
Ruiqi Liu, Bin Zhang, Shuting Zou, Li Cui, Lin Lin, Lingchang Li. Ginsenoside Rg1 Induces Autophagy in Colorectal Cancer through Inhibition of the Akt/mTOR/p70S6K Pathway. Journal of microbiology and biotechnology. 2024 Apr; 34(4):774-782. doi: 10.4014/jmb.2310.10043. [PMID: 38668684]
Baoyu Fu, Rui Ma, Fangbing Liu, Xuenan Chen, Manying Wang, Wenqi Jin, Shuai Zhang, Yanping Wang, Liwei Sun. New insights into ginsenoside Rg1 regulating the niche to inhibit age-induced germline stem cells depletion through targeting ECR/BMP signaling pathway in Drosophila. Aging. 2024 Feb; 16(4):3612-3630. doi: 10.18632/aging.205548. [PMID: 38364249]
Zhongjing Jiang, Linhua Deng, Mengjun Li, Emmanuel Alonge, Yanling Wang, Yunjia Wang. Ginsenoside Rg1 modulates PI3K/AKT pathway for enhanced osteogenesis via GPER. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Feb; 124(?):155284. doi: 10.1016/j.phymed.2023.155284. [PMID: 38176267]
Ning Jiang, Caihong Yao, Yiwen Zhang, Xinran Sun, M Iqbal Choudhary, Xinmin Liu. Ginsenoside Rg1 Attenuates Chronic Sleep Deprivation-Induced Hippocampal Mitochondrial Dysfunction and Improves Memory by the AMPK-SIRT3 Pathway. Journal of agricultural and food chemistry. 2024 Jan; 72(4):2362-2373. doi: 10.1021/acs.jafc.3c04618. [PMID: 38236060]
Huimin Zhou, Yan Liu, Yong Su, Pengmin Ji, Liangliang Kong, Ran Sun, Duoduo Zhang, Hanyang Xu, Weiping Li, Weizu Li. Ginsenoside Rg1 attenuates lipopolysaccharide-induced chronic liver damage by activating Nrf2 signaling and inhibiting inflammasomes in hepatic cells. Journal of ethnopharmacology. 2024 Jan; 324(?):117794. doi: 10.1016/j.jep.2024.117794. [PMID: 38244950]
Junpeng Long, Yang Sun, Shasha Liu, Chen Chen, Qian Yan, Yuting Lin, Zhao Zhang, Shifeng Chu, Yantao Yang, Songwei Yang, Meiyu Lin, Xuan Liu, Jinping Liang, Naihong Chen, Qidi Ai. Ginsenoside Rg1 treats ischemic stroke by regulating CKLF1/CCR5 axis-induced neuronal cell pyroptosis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 123(?):155238. doi: 10.1016/j.phymed.2023.155238. [PMID: 38128394]
Yadan Hu, Chao Xiang, Dong Zhang, Fang Zhou, Dede Zhang. Nephroprotective effect of Ginsenoside Rg1 in lipopolysaccharide-induced sepsis in mice through the SIRT1/NF-κB signaling. Folia histochemica et cytobiologica. 2024; 62(1):13-24. doi: 10.5603/fhc.97140. [PMID: 38563049]
Youbao Zhong, Qiuping Xiao, Jiaqi Huang, Songren Yu, Liling Chen, Qi Wan, Zheyan Zhang, Lin Luo, Lizhao Song, Haimei Zhao, Wen Zhou, Duanyong Liu. Ginsenoside Rg1 Alleviates Ulcerative Colitis in Obese Mice by Regulating the Gut Microbiota-Lipid Metabolism-Th1/Th2/Th17 Cells Axis. Journal of agricultural and food chemistry. 2023 Dec; 71(50):20073-20091. doi: 10.1021/acs.jafc.3c04811. [PMID: 38064669]
Pengmin Ji, Qifeng Shi, Yan Liu, Min Han, Yong Su, Ran Sun, Huimin Zhou, Weizu Li, Weiping Li. Ginsenoside Rg1 treatment alleviates renal fibrosis by inhibiting the NOX4-MAPK pathway in T2DM mice. Renal failure. 2023 Dec; 45(1):2197075. doi: 10.1080/0886022x.2023.2197075. [PMID: 37017270]
Chan Li, Yingbo Lin, Rukun Lin, Zhijie Chen, Qichun Zhou, Chaohua Luo, Zhixian Mo. Host miR-129-5p reverses effects of ginsenoside Rg1 on morphine reward possibly mediated by changes in B. vulgatus and serotonin metabolism in hippocampus. Gut microbes. 2023 12; 15(2):2254946. doi: 10.1080/19490976.2023.2254946. [PMID: 37698853]
Hui He, Xiaofang Xie, Xixi Kang, Jinqiang Zhang, Lu Wang, Nan Hu, Lei Xie, Cheng Peng, Zili You. Ginsenoside Rg1 ameliorates depressive-like behavior by inhibiting NLRP3 inflammasome activation in mice exposed to chronic stress. European journal of pharmacology. 2023 Oct; ?(?):176120. doi: 10.1016/j.ejphar.2023.176120. [PMID: 37863415]
Huan Liu, Rui Deng, Cheng-Wei Zhu, Hong-Kuan Han, Gang-Fan Zong, Lang Ren, Peng Cheng, Zhong-Hong Wei, Yang Zhao, Su-Yun Yu, Yin Lu. Rosmarinic acid in combination with ginsenoside Rg1 suppresses colon cancer metastasis via co-inhition of COX-2 and PD1/PD-L1 signaling axis. Acta pharmacologica Sinica. 2023 Sep; ?(?):. doi: 10.1038/s41401-023-01158-8. [PMID: 37749237]
Qianyan Gao, Guodong Li, Yue Zu, Yanjiao Xu, Congyi Wang, Dong Xiang, Wenxi He, Tianze Shang, Xinwei Cheng, Dong Liu, Chengliang Zhang. Ginsenoside Rg1 alleviates ANIT-induced cholestatic liver injury by inhibiting hepatic inflammation and oxidative stress via SIRT1 activation. Journal of ethnopharmacology. 2023 Aug; ?(?):117089. doi: 10.1016/j.jep.2023.117089. [PMID: 37634749]
Haifei Lu, Yini Zhang, Simiao Ran, Yumeng Chen, Zijing Ye, Mengying Huang, Ping Wang. Ginsenoside Rg1 alleviates sleep deprivation-induced learning and memory impairment by inhibiting excessive neuronal apoptosis in zebrafish. Neuroreport. 2023 Aug; 34(11):566-574. doi: 10.1097/wnr.0000000000001926. [PMID: 37384937]
Jiao-Jiao Wu, Li Zhang, Dong Liu, Jia Xia, Yu Yang, Fei Tang, Lu Chen, Hui Ao, Cheng Peng. Ginsenoside Rg1, lights up the way for the potential prevention of Alzheimer's disease due to its therapeutic effects on the drug-controllable risk factors of Alzheimer's disease. Journal of ethnopharmacology. 2023 Aug; ?(?):116955. doi: 10.1016/j.jep.2023.116955. [PMID: 37536646]
Jun Guo, Long Chen, Min Ma. Ginsenoside Rg1 Suppresses Ferroptosis of Renal Tubular Epithelial Cells in Sepsis-induced Acute Kidney Injury via the FSP1-CoQ10-NAD(P)H Pathway. Current medicinal chemistry. 2023 Jun; ?(?):. doi: 10.2174/0929867330666230607125054. [PMID: 37287288]
Yize Liu, Zheng-Yun Jin, Jun-Xia Wang, Danqi Wang, Hongye Liu, Dongxu Li, Jun Zhu, Zhao-Bo Luo, Sheng-Zhong Han, Shuang-Yan Chang, Liu-Hui Yang, Jin-Dan Kang, Lin-Hu Quan. Ginsenoside Rg1 activates brown adipose tissue to counteract obesity in high-fat diet-fed mice by regulating gut microbes and bile acid composition. Food & function. 2023 May; 14(10):4696-4705. doi: 10.1039/d2fo03142f. [PMID: 37186251]
Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
Weidong Hu, Shicheng Bi, Jianjian Shao, Yiwen Qu, Li Zhang, Jun Li, Sihuai Chen, Yue Ma, Liting Cao. Ginsenoside Rg1 and Re alleviates inflammatory responses and oxidative stress of broiler chicks challenged by lipopolysaccharide. Poultry science. 2023 Apr; 102(4):102536. doi: 10.1016/j.psj.2023.102536. [PMID: 36764136]
Linwei Chen, Nina Wei, Yong Jiang, Chengye Yuan, Luwei Xu, Jindong Li, Min Kong, Yan Chen, Qin Wang. Comparative pharmacokinetics of seven bioactive components after oral administration of crude and processed Qixue Shuangbu Prescription in chronic heart failure rats by microdialysis combined with UPLC-MS/MS. Journal of ethnopharmacology. 2023 Mar; 303(?):116035. doi: 10.1016/j.jep.2022.116035. [PMID: 36513265]
Min Wen, Lipan Yang, Hefei Huang, Gu Ye, Yuntao Jiang, Xiaobo Lv. Development of na HPLC-MS/MS method for the determination of ginsenosides Rg1 and Rb1 from 'Shenmai' Injection in beagle dogs after single and multiple doses and application in pharmacokinetics. Biomedical chromatography : BMC. 2023 Mar; 37(3):e5565. doi: 10.1002/bmc.5565. [PMID: 36515658]
Silu Liu, Hongyan Pei, Weijia Chen, Xiaoying Zhu, Yu Wang, Jianming Li, Zhongmei He, Rui Du. Evaluating the effect of ginsenoside Rg1 on CPF-induced brain injury in mice via PI3k/AKT pathway. Journal of biochemical and molecular toxicology. 2023 Feb; ?(?):e23319. doi: 10.1002/jbt.23319. [PMID: 36811218]
Ying Zhang, Chunli Guo, Hongmei Liu, Lin Yang, Changying Ren, Tao Li, Jianxun Liu. Multiplex quantitation of 17 drug-derived components in human plasma after administration of a fixed herbal preparation of Sailuotong using combined online SPE-LC-MS/MS methods. Journal of ethnopharmacology. 2023 Feb; 302(Pt A):115843. doi: 10.1016/j.jep.2022.115843. [PMID: 36265676]
Yuli Han, Yong Su, Min Han, Yan Liu, Qifeng Shi, Xuewang Li, Penghui Wang, Weiping Li, Weizu Li. Ginsenoside Rg1 attenuates glomerular fibrosis by inhibiting CD36/TRPC6/NFAT2 signaling in type 2 diabetes mellitus mice. Journal of ethnopharmacology. 2023 Feb; 302(Pt A):115923. doi: 10.1016/j.jep.2022.115923. [PMID: 36375645]
Xuanxin Chen, Wei Xue, Jia Zhang, Jiayi Peng, Wenxiang Huang. Ginsenoside Rg1 attenuates the NASH phenotype by regulating the miR-375-3p/ATG2B/PTEN-AKT axis to mediate autophagy and pyroptosis. Lipids in health and disease. 2023 Feb; 22(1):22. doi: 10.1186/s12944-023-01787-2. [PMID: 36759837]
Qian Qu, Shu-Peng Li, Qi Dong, Hong-Liang Du, Zhi-Hua Wang, Yi-Mu Ma, Xiao-Pei Gong, Yi-Qing Ding, Jing Zhou, Jia-Yan Chen, Meng-Jie Liu, Wei-Jie Lv, Shi-Ning Guo. Transcriptome profiling Revealed the potential mechanisms of Shen Lin Bai Zhu San n-butanol extract on DSS induced Colitis in Mice and LC-MS analysis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Feb; 110(?):154645. doi: 10.1016/j.phymed.2023.154645. [PMID: 36634382]
Yuqian Zhu, Jingyao Chen, Jun Li, Chenqi Zhou, Xin Huang, Bingdi Chen. Ginsenoside Rg1 as a promising adjuvant agent for enhancing the anti-cancer functions of granulocytes inhibited by noradrenaline. Frontiers in immunology. 2023; 14(?):1070679. doi: 10.3389/fimmu.2023.1070679. [PMID: 36817446]
Ningning Zhang, Hong Jiang, Huiqin Wang, Yating Wang, Ye Peng, Yangbo Liu, Congyuan Xia, Xu Yan, Shifeng Chu, Yi Zhang, Zhenzhen Wang, Naihong Chen. Novel Antidepressant Mechanism of Ginsenoside Rg1 in Regulating the Dysfunction of the Glutamatergic System in Astrocytes. International journal of molecular sciences. 2022 Dec; 24(1):. doi: 10.3390/ijms24010575. [PMID: 36614017]
Jun Guo, Rong Wang, Fei Min. Ginsenoside Rg1 ameliorates sepsis-induced acute kidney injury by inhibiting ferroptosis in renal tubular epithelial cells. Journal of leukocyte biology. 2022 11; 112(5):1065-1077. doi: 10.1002/jlb.1a0422-211r. [PMID: 35774015]
Man Peng, Liming Wang, Hui Su, Lei Zhang, Yue Yang, Le Sun, Yi Wu, Lei Ran, Sida Liu, Min Yin, Shude Li, Weixun Chunyu. Ginsenoside Rg1 improved diabetes through regulating the intestinal microbiota in high-fat diet and streptozotocin-induced type 2 diabetes rats. Journal of food biochemistry. 2022 10; 46(10):e14321. doi: 10.1111/jfbc.14321. [PMID: 35851705]
Qiong Li, Yu Zhan, Yonghua Xu, Lianxue Zhang, Peng Di, Baohui Lu, Changbao Chen. Deciphering the transcriptomic response of Ilyonectria robusta in relation to ginsenoside Rg1 treatment and the development of ginseng rusty root rot. FEMS microbiology letters. 2022 09; 369(1):. doi: 10.1093/femsle/fnac075. [PMID: 35945650]
Jiying Hou, Ruoxiang Ma, Shisheng Zhu, Yaping Wang. Revealing the Therapeutic Targets and Mechanism of Ginsenoside Rg1 for Liver Damage Related to Anti-Oxidative Stress Using Proteomic Analysis. International journal of molecular sciences. 2022 Sep; 23(17):. doi: 10.3390/ijms231710045. [PMID: 36077440]
Yang Sun, Yantao Yang, Shasha Liu, Songwei Yang, Chen Chen, Meiyu Lin, Qi Zeng, Junpeng Long, Jiao Yao, Fan Yi, Lei Meng, Qidi Ai, Naihong Chen. New Therapeutic Approaches to and Mechanisms of Ginsenoside Rg1 against Neurological Diseases. Cells. 2022 08; 11(16):. doi: 10.3390/cells11162529. [PMID: 36010610]
Han Li, Yun-Hang Gao, Ling Song, Teng-Fei Chen, Guang-Ping Zhang, Zu-Guang Ye, Yue Gao, Wang Huo. Ginsenoside Rg1 protects mice against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced liver injury by inhibiting CYP1A1 through the aryl hydrocarbon receptor. Journal of ethnopharmacology. 2022 Aug; 294(?):115394. doi: 10.1016/j.jep.2022.115394. [PMID: 35595219]
Jiao-Jiao Wu, Yu Yang, Yan Wan, Jia Xia, Jin-Feng Xu, Li Zhang, Dong Liu, Lu Chen, Fei Tang, Hui Ao, Cheng Peng. New insights into the role and mechanisms of ginsenoside Rg1 in the management of Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Aug; 152(?):113207. doi: 10.1016/j.biopha.2022.113207. [PMID: 35667236]
Duoduo Zhang, Pengmin Ji, Ran Sun, Huimin Zhou, Lei Huang, Liangliang Kong, Weiping Li, Weizu Li. Ginsenoside Rg1 attenuates LPS-induced chronic renal injury by inhibiting NOX4-NLRP3 signaling in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jun; 150(?):112936. doi: 10.1016/j.biopha.2022.112936. [PMID: 35421784]
Ying Chen, Yan-Yan Li, Shuo Wang, Tiantian Zhou, Nai-Hong Chen, Yu-He Yuan. Ginsenoside Rg1 Plays a Neuroprotective Role in Regulating the Iron-Regulated Proteins and Against Lipid Peroxidation in Oligodendrocytes. Neurochemical research. 2022 Jun; 47(6):1721-1735. doi: 10.1007/s11064-022-03564-6. [PMID: 35229270]
Zhijie Chen, Yingbo Lin, Qichun Zhou, Shilin Xiao, Chan Li, Rukun Lin, Jing Li, Yifei Chen, Chaohua Luo, Zhixian Mo. Ginsenoside Rg1 mitigates morphine dependence via regulation of gut microbiota, tryptophan metabolism, and serotonergic system function. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jun; 150(?):112935. doi: 10.1016/j.biopha.2022.112935. [PMID: 35447543]
Jingyi Mao, Xin Ma, Jiong Zhu, Huimin Zhang. Ginsenoside Rg1 ameliorates psoriasis-like skin lesions by suppressing proliferation and NLRP3 inflammasomes in keratinocytes. Journal of food biochemistry. 2022 05; 46(5):e14053. doi: 10.1111/jfbc.14053. [PMID: 35218026]
Junnan Li, Wei Gao, Zhonghui Zhao, Yannan Li, Lixuan Yang, Wei Wei, Feifei Ren, Yang Li, Yao Yu, Wenzhe Duan, Jingchun Li, Baoan Dai, Rongjuan Guo. Ginsenoside Rg1 Reduced Microglial Activation and Mitochondrial Dysfunction to Alleviate Depression-Like Behaviour Via the GAS5/EZH2/SOCS3/NRF2 Axis. Molecular neurobiology. 2022 May; 59(5):2855-2873. doi: 10.1007/s12035-022-02740-7. [PMID: 35230663]
Jian Long, Xue-Ke Liu, Zeng-Ping Kang, Meng-Xue Wang, Hai-Mei Zhao, Jia-Qi Huang, Qiu-Ping Xiao, Duan-Yong Liu, You-Bao Zhong. Ginsenoside Rg1 ameliorated experimental colitis by regulating the balance of M1/M2 macrophage polarization and the homeostasis of intestinal flora. European journal of pharmacology. 2022 Feb; 917(?):174742. doi: 10.1016/j.ejphar.2022.174742. [PMID: 34999087]
Hao Cheng, Juan Liu, Dandan Zhang, Jing Wang, Yuzhu Tan, Wuwen Feng, Cheng Peng. Ginsenoside Rg1 Alleviates Acute Ulcerative Colitis by Modulating Gut Microbiota and Microbial Tryptophan Metabolism. Frontiers in immunology. 2022; 13(?):817600. doi: 10.3389/fimmu.2022.817600. [PMID: 35655785]
Shengcui Liu, Junhua Huang, Fucun Gao, Zhiping Yin, Ruikui Zhang. Ginsenoside RG1 augments doxorubicin-induced apoptotic cell death in MDA-MB-231 breast cancer cell lines. Journal of biochemical and molecular toxicology. 2022 Jan; 36(1):e22945. doi: 10.1002/jbt.22945. [PMID: 34783124]
Xiao-Hu Liu, Shi-Zhong Cai, Yue Zhou, Ya-Ping Wang, Yan-Jun Han, Cui-Li Wang, Wen Zhou. Ginsenoside Rg1 Attenuates Premature Ovarian Failure of D-gal Induced POF Mice Through Downregulating p16INK4a and Upregulating SIRT1 Expression. Endocrine, metabolic & immune disorders drug targets. 2022; 22(3):318-327. doi: 10.2174/1871523020666210830164152. [PMID: 34463232]
Teng-Teng Ren, Jia-Ying Yang, Jun Wang, Sheng-Rui Fan, Rongfeng Lan, Xiao-Yan Qin. Gisenoside Rg1 attenuates cadmium-induced neurotoxicity in vitro and in vivo by attenuating oxidative stress and inflammation. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2021 Dec; 70(10-12):1151-1164. doi: 10.1007/s00011-021-01513-7. [PMID: 34661679]
Liang Huang, Hua-An Cai, Ming-Sheng Zhang, Ruo-Yi Liao, Xing Huang, Feng-Dan Hu. Ginsenoside Rg1 promoted the wound healing in diabetic foot ulcers via miR-489-3p/Sirt1 axis. Journal of pharmacological sciences. 2021 Nov; 147(3):271-283. doi: 10.1016/j.jphs.2021.07.008. [PMID: 34507636]
Jing Jin, Youbao Zhong, Jian Long, Tiantian Wu, Qingqing Jiang, Haiyan Wang, Wei Ge, Haimei Zhao, Duanyong Liu. Ginsenoside Rg1 relieves experimental colitis by regulating balanced differentiation of Tfh/Treg cells. International immunopharmacology. 2021 Nov; 100(?):108133. doi: 10.1016/j.intimp.2021.108133. [PMID: 34543978]
Hui-Qin Wang, Song-Wei Yang, Yan Gao, Ying-Jiao Liu, Xun Li, Qi-Di Ai, Mei-Yu Lin, Yan-Tao Yang, Qi Zeng, Yi Zhang, Zhen-Zhen Wang, Nai-Hong Chen. Novel antidepressant mechanism of ginsenoside Rg1: Regulating biosynthesis and degradation of connexin43. Journal of ethnopharmacology. 2021 Oct; 278(?):114212. doi: 10.1016/j.jep.2021.114212. [PMID: 34087399]
Ziling Wang, Lu Wang, Rong Jiang, Chang Li, Xiongbin Chen, Hanxianzhi Xiao, Jiying Hou, Ling Hu, Caihong Huang, Yaping Wang. Ginsenoside Rg1 prevents bone marrow mesenchymal stem cell senescence via NRF2 and PI3K/Akt signaling. Free radical biology & medicine. 2021 10; 174(?):182-194. doi: 10.1016/j.freeradbiomed.2021.08.007. [PMID: 34364981]
Huiqin Cao, Wei Wei, Ruirong Xu, Xing Cui. Ginsenoside Rg1 can restore hematopoietic function by inhibiting Bax translocation-mediated mitochondrial apoptosis in aplastic anemia. Scientific reports. 2021 06; 11(1):12742. doi: 10.1038/s41598-021-91471-1. [PMID: 34140535]
Wenlong Wei, Zhenwei Li, Haojv Li, Yaling An, Hua Qu, Changliang Yao, Jianqing Zhang, Jiayuan Li, Gaole Zhang, Yanchao Shi, De-An Guo. Exploration of tissue distribution of ginsenoside Rg1 by LC-MS/MS and nanospray desorption electrospray ionization mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2021 May; 198(?):113999. doi: 10.1016/j.jpba.2021.113999. [PMID: 33706145]
Xiaolei Xu, Zhenting Qu, Honghao Qian, Zhongming Li, Xiuling Sun, Xinrui Zhao, Huan Li. Ginsenoside Rg1 ameliorates reproductive function injury in C57BL/6J mice induced by di-N-butyl-phthalate. Environmental toxicology. 2021 May; 36(5):789-799. doi: 10.1002/tox.23081. [PMID: 33331133]
Yuqian Guo, Limei Wang, Jiangli Lu, Jianlin Jiao, Yi Yang, Hongbin Zhao, Zhang Liang, Hong Zheng. Ginsenoside Rg1 improves cognitive capability and affects the microbiota of large intestine of tree shrew model for Alzheimer's disease. Molecular medicine reports. 2021 04; 23(4):. doi: 10.3892/mmr.2021.11931. [PMID: 33649817]
Chan Mo, Shuwen Xie, Ting Zeng, Yuqi Lai, Sha Huang, Chuying Zhou, Weixin Yan, Shaohui Huang, Lei Gao, Zhiping Lv. Ginsenoside-Rg1 acts as an IDO1 inhibitor, protects against liver fibrosis via alleviating IDO1-mediated the inhibition of DCs maturation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Apr; 84(?):153524. doi: 10.1016/j.phymed.2021.153524. [PMID: 33667840]
Wei Xue, Yan Gao, Pan-Pan Xie, Yang Liu, Wen-Yuan Qi, Ai-Xin Shi, Ke-Xin Li. Plasma and intracerebral pharmacokinetics and pharmacodynamics modeling for the acetylcholine releasing effect of ginsenoside Rg1 in mPFC of Aβ model rats. Journal of Asian natural products research. 2021 Mar; 23(3):294-306. doi: 10.1080/10286020.2020.1803289. [PMID: 33771049]
Cheng Yang, Xiaoqing He, Jinqiu Zhao, Wenxiang Huang. Hepatoprotection by Ginsenoside Rg1 in alcoholic liver disease. International immunopharmacology. 2021 Mar; 92(?):107327. doi: 10.1016/j.intimp.2020.107327. [PMID: 33412392]
Danshan Gu, Haoan Yi, Kerong Jiang, Syed Hassam Fakhar, Jing Shi, Yongshu He, Bo Liu, Yunping Guo, Xiaoming Fan, Shude Li. Transcriptome analysis reveals the efficacy of ginsenoside-Rg1 in the treatment of nonalcoholic fatty liver disease. Life sciences. 2021 Feb; 267(?):118986. doi: 10.1016/j.lfs.2020.118986. [PMID: 33385408]
Jie Zhang, Sheng-Lan Liu, Hui Wang, Li-Ying Shi, Jin-Ping Li, Lu-Juan Jia, Bao-Ping Xie. The effects of borneol on the pharmacokinetics and brain distribution of tanshinone IIA, salvianolic acid B and ginsenoside Rg1 in Fufang Danshen preparation in rats. Chinese journal of natural medicines. 2021 Feb; 19(2):153-160. doi: 10.1016/s1875-5364(21)60016-x. [PMID: 33641786]
Tong Hou, Yang Liu, Xiaoyun Wang, Danli Jiao, Hao Xu, Qi Shi, Yongjun Wang, Wei Li, Tao Wu, Qianqian Liang. Ginsenoside Rg1 promotes lymphatic drainage and improves chronic inflammatory arthritis. Journal of musculoskeletal & neuronal interactions. 2020 12; 20(4):526-534. doi: NULL. [PMID: 33265080]
Yue Gao, Shujun Zhang, Jiajun Li, Jinqiu Zhao, Qing Xiao, Yali Zhu, Jia Zhang, Wenxiang Huang. Effect and mechanism of ginsenoside Rg1-regulating hepatic steatosis in HepG2 cells induced by free fatty acid. Bioscience, biotechnology, and biochemistry. 2020 Nov; 84(11):2228-2240. doi: 10.1080/09168451.2020.1793293. [PMID: 32654591]
Xiping Mei, Huibin Feng, Bibo Shao. Alleviation of sepsis-associated encephalopathy by ginsenoside via inhibition of oxidative stress and cell apoptosis: An experimental study. Pakistan journal of pharmaceutical sciences. 2020 Nov; 33(6):2567-2577. doi: . [PMID: 33867332]
Anling Hu, Zhiqin Shuai, Jiajia Liu, Bo Huang, Yunmei Luo, Jiang Deng, Jie Liu, Limei Yu, Lisheng Li, Shangfu Xu. Ginsenoside Rg1 prevents vascular intimal hyperplasia involved by SDF-1α/CXCR4, SCF/c-kit and FKN/CX3CR1 axes in a rat balloon injury. Journal of ethnopharmacology. 2020 Oct; 260(?):113046. doi: 10.1016/j.jep.2020.113046. [PMID: 32504784]
Yan Gao, Juntong Li, Jin Wang, Xiang Li, Jianping Li, Shifeng Chu, Lin Li, Naihong Chen, Lan Zhang. Ginsenoside Rg1 prevent and treat inflammatory diseases: A review. International immunopharmacology. 2020 Oct; 87(?):106805. doi: 10.1016/j.intimp.2020.106805. [PMID: 32731179]
Yu-Xia Lou, Zhen-Zhen Wang, Cong-Yuan Xia, Zheng Mou, Qian Ren, Dan-Dan Liu, Xin Zhang, Nai-Hong Chen. The protective effect of ginsenoside Rg1 on depression may benefit from the gap junction function in hippocampal astrocytes. European journal of pharmacology. 2020 Sep; 882(?):173309. doi: 10.1016/j.ejphar.2020.173309. [PMID: 32598952]
Jin He, Qingtan Yu, Chunlan Wu, Zhimin Sun, Xiaoyong Wu, Rong Liu, Hong Zhang. Acupuncture of the Beishu acupoint participates in regulatory effects of ginsenoside Rg1 on T cell subsets of rats with chronic fatigue syndrome. Annals of palliative medicine. 2020 Sep; 9(5):3436-3446. doi: 10.21037/apm-20-1714. [PMID: 33065794]
Yao Cheng, Ruimei Li, Zixuan Lin, Feiyan Chen, Jianguo Dai, Zhu Zhu, Lin Chen, Yunan Zhao. Structure-activity relationship analysis of dammarane-type natural products as muscle-type creatine kinase activators. Bioorganic & medicinal chemistry letters. 2020 09; 30(17):127364. doi: 10.1016/j.bmcl.2020.127364. [PMID: 32738969]
Tianqian Jin, Zuhui Liu, Yang Chu, Xiaohui Ma, Shuming Li, Xiangyang Wang, Genbei Wang, Shuiping Zhou, He Sun, Jin Yang. UFLC-MS/MS Determination and Population Pharmacokinetic Study of Tanshinol, Ginsenoside Rb1 and Rg1 in Rat Plasma After Oral Administration of Compound Danshen Dripping Pills. European journal of drug metabolism and pharmacokinetics. 2020 Aug; 45(4):523-533. doi: 10.1007/s13318-020-00618-4. [PMID: 32304023]
Rongjia Qi, Rong Jiang, Hanxianzhi Xiao, Ziling Wang, Siyuan He, Lu Wang, Yaping Wang. Ginsenoside Rg1 protects against d-galactose induced fatty liver disease in a mouse model via FOXO1 transcriptional factor. Life sciences. 2020 Aug; 254(?):117776. doi: 10.1016/j.lfs.2020.117776. [PMID: 32437790]
Wei Sun, Fengyi Zhang, Hui Wang, Chen Wang, Zangong Zhou, Yu Zhou. Ginsenoside Rg1 fails to rescue PTSD-like behaviors in a mice model of single-prolonged stress. Biochemical and biophysical research communications. 2020 07; 528(2):243-248. doi: 10.1016/j.bbrc.2020.05.159. [PMID: 32482388]
Ning Jiang, Jingwei Lv, Haixia Wang, Hong Huang, Qiong Wang, Cong Lu, Guirong Zeng, Xin-Min Liu. Ginsenoside Rg1 ameliorates chronic social defeat stress-induced depressive-like behaviors and hippocampal neuroinflammation. Life sciences. 2020 Jul; 252(?):117669. doi: 10.1016/j.lfs.2020.117669. [PMID: 32298740]
Hong Shen, Li Zhang, Jin-Di Xu, Yong-Fang Ding, Jing Zhou, Jie Wu, Wei Zhang, Qian Mao, Li-Fang Liu, He Zhu, Song-Lin Li. Effect of sulfur-fumigation process on ginseng: Metabolism and absorption evidences. Journal of ethnopharmacology. 2020 Jun; 256(?):112799. doi: 10.1016/j.jep.2020.112799. [PMID: 32243989]
Cong-Yuan Xia, Zhen-Zhen Wang, Hui-Qin Wang, Si-Yu Ren, Yu-Xia Lou, Can Jin, Tian-Ge Qu, Si-Tong Feng, Yi Zhang, Shi-Feng Chu, Nai-Hong Chen. Connexin 43: A novel ginsenoside Rg1-sensitive target in a rat model of depression. Neuropharmacology. 2020 06; 170(?):108041. doi: 10.1016/j.neuropharm.2020.108041. [PMID: 32213357]
Qing Xiao, Shujun Zhang, Huina Ren, Ruoyang Du, Jiajun Li, Jinqiu Zhao, Yue Gao, Yali Zhu, Wenxiang Huang. Ginsenoside Rg1 alleviates ANIT-induced intrahepatic cholestasis in rats via activating farnesoid X receptor and regulating transporters and metabolic enzymes. Chemico-biological interactions. 2020 Jun; 324(?):109062. doi: 10.1016/j.cbi.2020.109062. [PMID: 32198087]
Yanwen Xu, Liang Yang, Kun Liang, Rui An, Xinhong Wang, Hai Zhang. Pharmacokinetic effects of ginsenoside Rg1 on aconitine, benzoylaconine and aconine by UHPLC-MS/MS. Biomedical chromatography : BMC. 2020 Apr; 34(4):e4793. doi: 10.1002/bmc.4793. [PMID: 31919877]
Raphael N Alolga, Gloria F Nuer-Allornuvor, Eugene D Kuugbee, Xiaojian Yin, Gaoxiang Ma. Ginsenoside Rg1 and the control of inflammation implications for the therapy of type 2 diabetes: A review of scientific findings and call for further research. Pharmacological research. 2020 02; 152(?):104630. doi: 10.1016/j.phrs.2020.104630. [PMID: 31911245]
Xiaojuan Guo, Jingyuan Zhang, Min Liu, Guo Chen Zhao. Protective effect of ginsenoside Rg1 on attenuating anti-GBM glomerular nephritis by activating NRF2 signalling. Artificial cells, nanomedicine, and biotechnology. 2019 Dec; 47(1):2972-2979. doi: 10.1080/21691401.2019.1640712. [PMID: 31322005]
Quan Shi, Qi He, Weiming Chen, Jianwen Long, Bo Zhang. Ginsenoside Rg1 abolish imiquimod-induced psoriasis-like dermatitis in BALB/c mice via downregulating NF-κB signaling pathway. Journal of food biochemistry. 2019 11; 43(11):e13032. doi: 10.1111/jfbc.13032. [PMID: 31502279]
Hua-An Cai, Liang Huang, Li-Jun Zheng, Kun Fu, Jing Wang, Feng-Dan Hu, Ruo-Yi Liao. Ginsenoside (Rg-1) promoted the wound closure of diabetic foot ulcer through iNOS elevation via miR-23a/IRF-1 axis. Life sciences. 2019 Sep; 233(?):116525. doi: 10.1016/j.lfs.2019.05.081. [PMID: 31158376]
Ying Ying, Yi-Lin Zhang, Can-Jie Ma, Mei-Qi Li, Chao-Yue Tang, Yang-Fan Yang, Jun-Hui Zeng, Xiao-Yan Huang, Junbo Yi, Xiao-Mei Wang, Zhen-Dan He, Xing-Sheng Shu. Neuroprotective Effects of Ginsenoside Rg1 against Hyperphosphorylated Tau-Induced Diabetic Retinal Neurodegeneration via Activation of IRS-1/Akt/GSK3β Signaling. Journal of agricultural and food chemistry. 2019 Jul; 67(30):8348-8360. doi: 10.1021/acs.jafc.9b02954. [PMID: 31304751]
Xiaoming Fan, Chao Zhang, Shiwei Niu, Biao Fan, Danshan Gu, Kerong Jiang, Ruonan Li, Shude Li. Ginsenoside Rg1 attenuates hepatic insulin resistance induced by high-fat and high-sugar by inhibiting inflammation. European journal of pharmacology. 2019 Jul; 854(?):247-255. doi: 10.1016/j.ejphar.2019.04.027. [PMID: 31002778]
Yuemin Wang, Yong Zhang, Xiaoqing Chi, Xiaodan Ma, Wei Xu, Fushan Shi, Songhua Hu. Anti-inflammatory mechanism of ginsenoside Rg1: Proteomic analysis of milk from goats with mastitis induced with lipopolysaccharide. International immunopharmacology. 2019 Jun; 71(?):382-391. doi: 10.1016/j.intimp.2019.03.048. [PMID: 30952102]
Wei Li, Yi Wu, Mali Wan, Yang Chu, Xiangyang Wang, Shuming Li, Zuhui Liu, Xue Chen, Navaneethakrishnan Polachi, Shuiping Zhou, He Sun. Simultaneous determination of three saponins in human plasma after oral administration of compound danshen dripping pills by LC-MS/MS and its application in a pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 2019 May; 169(?):254-259. doi: 10.1016/j.jpba.2019.03.008. [PMID: 30878903]
Lan Luo, Jiazhen Kang, Qiong He, Yue Qi, Xingyu Chen, Shumei Wang, Shengwang Liang. A NMR-Based Metabonomics Approach to Determine Protective Effect of a Combination of Multiple Components Derived from Naodesheng on Ischemic Stroke Rats. Molecules (Basel, Switzerland). 2019 May; 24(9):. doi: 10.3390/molecules24091831. [PMID: 31086027]
Ge Li, Ning Zhang, Fang Geng, Guoliang Liu, Bin Liu, Xia Lei, Guang Li, Xi Chen. High-throughput metabolomics and ingenuity pathway approach reveals the pharmacological effect and targets of Ginsenoside Rg1 in Alzheimer's disease mice. Scientific reports. 2019 05; 9(1):7040. doi: 10.1038/s41598-019-43537-4. [PMID: 31065079]
Jie Zhou, Zhi-Fang Ran, Xiao-Tong Yang, Jia Li. Postharvest UV-B Irradiation Stimulated Ginsenoside Rg1 Biosynthesis through Nitric Oxide (NO) and Jasmonic Acid (JA) in Panax quinquefolius Roots. Molecules (Basel, Switzerland). 2019 Apr; 24(8):. doi: 10.3390/molecules24081462. [PMID: 31013885]
Zhekang Cheng, Meng Zhang, Chengli Ling, Ying Zhu, Hongwei Ren, Chao Hong, Jing Qin, Tongxiang Liu, Jianxin Wang. Neuroprotective Effects of Ginsenosides against Cerebral Ischemia. Molecules (Basel, Switzerland). 2019 Mar; 24(6):. doi: 10.3390/molecules24061102. [PMID: 30897756]
Y M Wang, Y Q Ma, S C Bi, X D Ma, R Guan, S H Wang, M Q Lu, F S Shi, S H Hu. Therapeutic effect of ginsenoside Rg1 on mastitis experimentally induced by lipopolysaccharide in lactating goats. Journal of dairy science. 2019 Mar; 102(3):2443-2452. doi: 10.3168/jds.2018-15280. [PMID: 30612791]
Jin-Chul Kim, Joo-Yeong Jeon, Woong-Suk Yang, Cheorl-Ho Kim, Dae-Woon Eom. Combined Amelioration of Ginsenoside (Rg1, Rb1, and Rg3)-enriched Korean Red Ginseng and Probiotic Lactobacillus on Non-alcoholic Fatty Liver Disease. Current pharmaceutical biotechnology. 2019; 20(3):222-231. doi: 10.2174/1389201020666190311143554. [PMID: 30854954]
Yashu Xu, Cheng Yang, Shujun Zhang, Jiajun Li, Qing Xiao, Wenxiang Huang. Ginsenoside Rg1 Protects against Non-alcoholic Fatty Liver Disease by Ameliorating Lipid Peroxidation, Endoplasmic Reticulum Stress, and Inflammasome Activation. Biological & pharmaceutical bulletin. 2018 Nov; 41(11):1638-1644. doi: 10.1248/bpb.b18-00132. [PMID: 30135326]
Chenqing Ning, Xiaoguang Gao, Changyuan Wang, Yulong Kong, Zhihao Liu, Huijun Sun, Pengyuan Sun, Xiaokui Huo, Xiaodong Ma, Qiang Meng, Kexin Liu. Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro. Regulatory toxicology and pharmacology : RTP. 2018 Oct; 98(?):58-68. doi: 10.1016/j.yrtph.2018.07.012. [PMID: 30030101]
Chenqing Ning, Xiaoguang Gao, Changyuan Wang, Xiaokui Huo, Zhihao Liu, Huijun Sun, Xiaobo Yang, Pengyuan Sun, Xiaodong Ma, Qiang Meng, Kexin Liu. Hepatoprotective effect of ginsenoside Rg1 from Panax ginseng on carbon tetrachloride-induced acute liver injury by activating Nrf2 signaling pathway in mice. Environmental toxicology. 2018 Oct; 33(10):1050-1060. doi: 10.1002/tox.22616. [PMID: 29964319]
Jun Lu, Lu Yao, Jin-Xin Li, Shu-Jie Liu, Yan-Ying Hu, Shi-Hui Wang, Wen-Xia Liang, Lu-Qi Huang, Yu-Jie Dai, Juan Wang, Wen-Yuan Gao. Characterization of UDP-Glycosyltransferase Involved in Biosynthesis of Ginsenosides Rg1 and Rb1 and Identification of Critical Conserved Amino Acid Residues for Its Function. Journal of agricultural and food chemistry. 2018 Sep; 66(36):9446-9455. doi: 10.1021/acs.jafc.8b02544. [PMID: 30095259]
Ni Zhen, Lei Jin, Ji Ma, Jiabei Zhu, Song Gu, Jing Wang, Qiuhui Pan, Xiaorong Ni, Min Xu. Ginsenoside Rg1 impairs homologous recombination repair by targeting CtBP-interacting protein and sensitizes hepatoblastoma cells to DNA damage. Anti-cancer drugs. 2018 09; 29(8):756-766. doi: 10.1097/cad.0000000000000646. [PMID: 29952772]
Ran Shi, Sishuo Zhang, Guangqing Cheng, Xiaoni Yang, Ningning Zhao, Chao Chen. Ginsenoside Rg1 and Acori Graminei Rhizoma Attenuates Neuron Cell Apoptosis by Promoting the Expression of miR-873-5p in Alzheimer's Disease. Neurochemical research. 2018 Aug; 43(8):1529-1538. doi: 10.1007/s11064-018-2567-y. [PMID: 29926354]
Huimin Liu, Jing Wang, Meihong Liu, Hongyu Zhao, Sanabil Yaqoob, Mingzhu Zheng, Dan Cai, Jingsheng Liu. Antiobesity Effects of Ginsenoside Rg1 on 3T3-L1 Preadipocytes and High Fat Diet-Induced Obese Mice Mediated by AMPK. Nutrients. 2018 Jun; 10(7):. doi: 10.3390/nu10070830. [PMID: 29954059]
Fugeng Zhang, Yu Zhang, Xiaofeng Li, Shaoqiang Zhang, Mingdan Zhu, Wuxun Du, Xuefeng Xiao. Research on Q-markers of Qiliqiangxin capsule for chronic heart failure treatment based on pharmacokinetics and pharmacodynamics association. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 May; 44(?):220-230. doi: 10.1016/j.phymed.2018.03.003. [PMID: 29699844]
Yi Zhong, Jieqiang Zhu, Zhenzhong Yang, Qing Shao, Xiaohui Fan, Yiyu Cheng. Q-marker based strategy for CMC research of Chinese medicine: A case study of Panax Notoginseng saponins. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 May; 44(?):129-137. doi: 10.1016/j.phymed.2018.01.023. [PMID: 29452723]