N-Nitrosodimethylamine (BioDeep_00000002954)
Secondary id: BioDeep_00001871737
human metabolite Endogenous
代谢物信息卡片
N-Methyl-N-nitrosomethanamine, 9ci
化学式: C2H6N2O (74.0480106)
中文名称: N-亚硝基二甲胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C)N=O
InChI: InChI=1S/C2H6N2O/c1-4(2)3-5/h1-2H3
描述信息
N-Nitrosodimethylamine is found in pepper (Capsicum annuum). N-Nitrosodimethylamine is a food contaminant especially in cured meat products. N-Nitrosodimethylamine (NDMA), also known as dimethylnitrosamine (DMN), is a semi-volatile organic chemical that is highly toxic and is a suspected human carcinogen. The US Environmental Protection Agency has determined that the maximum admissible concentration of NDMA in drinking water is 7 ng L 1. The EPA has not yet set a regulatory maximum contaminant level (MCL) for drinking water. At high doses, it is a "potent hepatotoxin that can cause fibrosis of the liver" in rats. The induction of liver tumors in rats after chronic exposure to low doses is well-documented. Its toxic effects on humans are inferred from animal experiments but not well-established experimentally. NDMA is an industrial by-product or waste product of several industrial processes. It first came to attention as a groundwater contaminant in California in 1998 and 1999 at several sites that produced rocket fuel. Manufacturing of unsymmetrical dimethylhydrazine (UDMH), which is a component of rocket fuel that requires NDMA for its synthesis, proved to be the culprit in these cases. Of more general concern, water treatment via chlorination or chloramination of organic nitrogen-containing wastewater can lead to the production of NDMA at potentially harmful levels. Further, NDMA can form or be leached during treatment of water by anion exchange resins. Finally, NDMA is found at low levels in numerous items of human consumption including cured meat, fish, beer, and tobacco smoke, it is, however, unlikely to bioaccumulate
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3447
Food contaminant especies in cured meat products
同义名列表
28 个代谢物同义名
N-Methyl-N-nitrosomethanamine, 9ci; N-Methyl-N-nitroso-methanamine; N-Methyl-N-nitrosomethanamine; N-Nitrosodimethylamine (NDMA); N-Methyl-N-nitroso-methamine; 1,1-Dimethyl-2-oxohydrazine; N-nitroso-N,N-Dimethylamine; Nitrosodimethylamine, ndma; NDMA nitrosodimethylamine; N, N-Dimethylnitrosamine; N,N-Dimethylnitrosamine; N-nitroso-Dimethylamine; N-Dimethyl-nitrosamine; N Nitrosodimethylamine; N-Dimethylnitrosoamine; dimethyl(nitroso)amine; N-NITROSODIMETHYLAMINE; N-Nitroaodimethylamine; Nitrous dimethylamide; Dimethylnitrosoamine; Nitrosodimethylamine; Dimethyl-nitrosamine; Dimethylnitrosamine; Dimethylnitrosamin; (CH3)2NNO; NDMA; DMNA; DMN
数据库引用编号
20 个数据库交叉引用编号
- ChEBI: CHEBI:35807
- KEGG: C14704
- PubChem: 6124
- HMDB: HMDB0031419
- Metlin: METLIN70275
- ChEMBL: CHEMBL117311
- Wikipedia: N-Nitrosodimethylamine
- MeSH: Dimethylnitrosamine
- foodb: FDB003496
- chemspider: 5894
- CAS: 62-75-9
- MoNA: EQ344706
- MoNA: EQ344705
- MoNA: EQ344703
- MoNA: EQ344704
- MoNA: EQ344701
- MoNA: EQ344702
- PMhub: MS000007342
- PubChem: 17395703
- NIKKAJI: J1.928C
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
- 3712 - Brassica oleracea: 10.1016/0304-3835(90)90092-C
- 9606 - Homo sapiens: -
- 4097 - Nicotiana tabacum: 10.1016/0378-8741(88)90069-4
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Folake Asejeje, Sylvia Etim, Gbolahan Asejeje, Benneth Chukwudi Iwuoh, Sanmi Ibukunoluwa Akintade, Isaac Adedara, Ebenezer Olatunde Farombi. Protocatechuic acid modulates hepatic oxidative stress and inflammation linked to DMN exposure in rat.
Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria.
2023 Dec; 38(2):145-155. doi:
10.54548/njps.v38i2.4. [PMID: 38696681] - Qin Zhou, Min Mo, Anliang Wang, Bobin Tang, Qiang He. Changes in N-nitrosamines, Residual Nitrites, Lipid Oxidation, Biogenic Amines, and Microbiota in Chinese Sausages Following Treatment with Tea Polyphenols and Their Palmitic Acid-modified Derivatives.
Journal of food protection.
2023 Mar; 86(5):100072. doi:
10.1016/j.jfp.2023.100072. [PMID: 37001484] - Sara M Soliman, Shaimaa Mosallam, Mohamed A Mamdouh, Mohammed Abdalla Hussein, Shady M Abd El-Halim. Design and optimization of cranberry extract loaded bile salt augmented liposomes for targeting of MCP-1/STAT3/VEGF signaling pathway in DMN-intoxicated liver in rats.
Drug delivery.
2022 Dec; 29(1):427-439. doi:
10.1080/10717544.2022.2032875. [PMID: 35098843] - Paradon Sonsomnuek, Mayuri Tarasuk, Tullayakorn Plengsuriyakarn, Kanyarat Boonprasert, Kesara Na-Bangchang. Apoptotic and Anti-metastatic Effects of Atractylodes lancea (Thunb.) DC. in a Hamster Model of Cholangiocarcinoma.
Asian Pacific journal of cancer prevention : APJCP.
2022 Sep; 23(9):3093-3101. doi:
10.31557/apjcp.2022.23.9.3093. [PMID: 36172672] - Joseph George, Mutsumi Tsuchishima, Mikihiro Tsutsumi. Epigallocatechin-3-gallate inhibits osteopontin expression and prevents experimentally induced hepatic fibrosis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Jul; 151(?):113111. doi:
10.1016/j.biopha.2022.113111. [PMID: 35594711] - Varsha Rani, Yeshvandra Verma, S V S Rana. Zinc Oxide Nanoparticles Ameliorate Dimethylnitrosamine-Induced Renal Toxicity in Rat.
Applied biochemistry and biotechnology.
2022 Apr; 194(4):1699-1715. doi:
10.1007/s12010-021-03689-4. [PMID: 34855113] - Ying Xu, Dingqi Zhang, Hailin Yang, Yu Liu, Linzhang Zhang, Congcong Zhang, Gaofeng Chen, Yonghong Hu, Jiamei Chen, Hua Zhang, Yongping Mu, Ping Liu, Wei Liu. Hepatoprotective effect of genistein against dimethylnitrosamine-induced liver fibrosis in rats by regulating macrophage functional properties and inhibiting the JAK2/STAT3/SOCS3 signaling pathway.
Frontiers in bioscience (Landmark edition).
2021 12; 26(12):1572-1584. doi:
10.52586/5050. [PMID: 34994171] - Gbadebo E Adeleke, Oluwatosin A Adaramoye. Betulinic acid abates N-nitrosodimethylamine-induced changes in lipid metabolism, oxidative stress, and inflammation in the liver and kidney of Wistar rats.
Journal of biochemical and molecular toxicology.
2021 Nov; 35(11):e22901. doi:
10.1002/jbt.22901. [PMID: 34472159] - Hadiya Husain, Mohammad Waseem, Riaz Ahmad. Proteomic and molecular evidences of Il1rl2, Ric8a, Krt18 and Hsp90b1 modulation during experimental hepatic fibrosis and pomegranate supplementation.
International journal of biological macromolecules.
2021 Aug; 185(?):696-707. doi:
10.1016/j.ijbiomac.2021.06.091. [PMID: 34174316] - Qian Zhang, Meng-Meng Shang, Qu-Fei Ling, Xiao-Ping Wu, Chun-Yu Liu. Hepatoprotective effects of loach (Misgurnus anguillicaudatus) lyophilized powder on dimethylnitrosamine-induced liver fibrosis in rats.
Archives of pharmacal research.
2021 Aug; 44(8):1-12. doi:
10.1007/s12272-014-0445-y. [PMID: 25074038] - Jeffry Florian, Murali K Matta, Ryan DePalma, Victoria Gershuny, Vikram Patel, Cheng-Hui Hsiao, Robbert Zusterzeel, Rodney Rouse, Kristin Prentice, Colleen Gosa Nalepinski, Insook Kim, Sojeong Yi, Liang Zhao, Miyoung Yoon, Susan Selaya, David Keire, Joyce Korvick, David G Strauss. Effect of Oral Ranitidine on Urinary Excretion of N-Nitrosodimethylamine (NDMA): A Randomized Clinical Trial.
JAMA.
2021 07; 326(3):240-249. doi:
10.1001/jama.2021.9199. [PMID: 34180947] - Xiaogang Mu, Xuanjun Wang, Yue Zhang, Bo Liu, Jingjing Yang. Major products and their formation and transformation mechanism through degrading UDMH wastewater via DBD low temperature plasma.
Environmental technology.
2021 Jul; 42(17):2709-2720. doi:
10.1080/09593330.2019.1710573. [PMID: 31903864] - Bo Zhao, Norihide Nakada. Contribution of N,N-dimethylformamide to formation of N-nitrosodimethylamine by chloramination in sewage treatment plants and receiving rivers.
Water research.
2021 Mar; 191(?):116827. doi:
10.1016/j.watres.2021.116827. [PMID: 33476799] - Binbin Li, Jiaxuan Liu, Xuan Xin, Lifen Zhang, Jiaming Zhou, Chunyan Xia, Weijian Zhu, Hongyu Yu. MiR-34c promotes hepatic stellate cell activation and Liver Fibrogenesis by suppressing ACSL1 expression.
International journal of medical sciences.
2021; 18(3):615-625. doi:
10.7150/ijms.51589. [PMID: 33437196] - Aya Naiki-Ito, Hiroyuki Kato, Taku Naiki, Ranchana Yeewa, Yoshinaga Aoyama, Yuko Nagayasu, Shugo Suzuki, Shingo Inaguma, Satoru Takahashi. A novel model of non-alcoholic steatohepatitis with fibrosis and carcinogenesis in connexin 32 dominant-negative transgenic rats.
Archives of toxicology.
2020 12; 94(12):4085-4097. doi:
10.1007/s00204-020-02873-5. [PMID: 32833043] - Tao Yang, Tian-Hui Zheng, Qiang Zhao, Wei Liu, Shu-Ping Li, Yan-Yan Tao, Chang-Hong Wang, Cheng-Hai Liu. Effects of Fuzheng Huayu recipe on entecavir pharmacokinetics in normal and dimethylnitrosamine-induced hepatic fibrosis rats.
Pharmaceutical biology.
2020 Dec; 58(1):1-7. doi:
10.1080/13880209.2019.1687527. [PMID: 31847670] - Changchuan Guo, Qi Liu, Lei Zhang, Jing Zheng, Yong Wang, Shujuan Yang, Zhijie Chu, Chong Niu, Yuwen Xu. [Determination of N-nitrosodimethylamine in metformin hydrochloride and its preparations by high performance liquid chromatography-tandem mass spectrometry].
Se pu = Chinese journal of chromatography.
2020 Nov; 38(11):1288-1293. doi:
10.3724/sp.j.1123.2020.03008. [PMID: 34213099] - Xiaolu Zhang, Daekyun Kim, David L Freedman, Tanju Karanfil. Impact of biological wastewater treatment on the reactivity of N-Nitrosodimethylamine precursors.
Water research.
2020 Nov; 186(?):116315. doi:
10.1016/j.watres.2020.116315. [PMID: 32846382] - Paolo Roccaro, Renata Finocchiaro, Julian Mamo, Maria José Farré. Monitoring NDMA precursors throughout membrane-based advanced wastewater treatment processes by organic matter fluorescence.
Water research.
2020 May; 175(?):115682. doi:
10.1016/j.watres.2020.115682. [PMID: 32193028] - Yu Qiu, Er Bei, Yufang Wang, Jun Wang, Xiaojian Zhang, Chao Chen. One representative water supply system in China with nitrosamine concern: Challenges and treatment strategies.
Journal of environmental sciences (China).
2020 Feb; 88(?):12-20. doi:
10.1016/j.jes.2019.08.005. [PMID: 31862053] - Suat Ekin, Hatice Kiziltas, Mahire Bayramoglu Akkoyun, Hasya Nazli Ekin, Serkan Yildirim, Gokhan Oto, Esvet Akbas, Didem Deliorman Orhan, Fevzi Ozgokce. Nephroprotective effect of Ferulago angulata flowers on N-nitrosodimethylamine-induced nephrotoxicity in rats and its phytochemical profile.
Journal of food biochemistry.
2019 11; 43(11):e13030. doi:
10.1111/jfbc.13030. [PMID: 31482601] - K A Shipkowski, J M Sanders, J D McDonald, C E Garner, M Doyle-Eisele, C J Wegerski, S Waidyanatha. Comparative disposition of dimethylaminoethanol and choline in rats and mice following oral or intravenous administration.
Toxicology and applied pharmacology.
2019 09; 378(?):114592. doi:
10.1016/j.taap.2019.05.011. [PMID: 31100288] - Zhenlong Yu, Yanan Jv, Lu Cai, Xiangge Tian, Xiaokui Huo, Chao Wang, Baojing Zhang, ChengPeng Sun, Jing Ning, Lei Feng, Houli Zhang, Xiaochi Ma. Gambogic acid attenuates liver fibrosis by inhibiting the PI3K/AKT and MAPK signaling pathways via inhibiting HSP90.
Toxicology and applied pharmacology.
2019 05; 371(?):63-73. doi:
10.1016/j.taap.2019.03.028. [PMID: 30953615] - Min Zheng, Yuan-Yuan Li, Guo-Feng Wang, Jing-Yi Jin, Ya-Hang Wang, Tian-Ming Wang, Li Yang, Shao-Yong Liu, Jia-Sheng Wu, Zheng-Tao Wang, Yue-Ming Ma. Protective effect of cultured bear bile powder against dimethylnitrosamine-induced hepatic fibrosis in rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Apr; 112(?):108701. doi:
10.1016/j.biopha.2019.108701. [PMID: 30818137] - Mengmeng Zhu, Qun Ye, Tingting Zhou, Lutao Chen, Luping Yu, Bin Li, Jinfeng Hu, Min Zhou. [Determination of 10 volatile N-nitrosamines in meat products by gas chromatography-tandem mass spectrometry].
Se pu = Chinese journal of chromatography.
2019 Feb; 37(2):207-215. doi:
10.3724/sp.j.1123.2018.09037. [PMID: 30693730] - Yuanyuan Yin, Tong Li, Duyi Kuang, Yuanan Lu, Yan Shen, Jun Xu, Songhui Jiang, Xia Wang. Probabilistic health risk assessment of nitrosamines in drinking water of Shaoxing, Zhejiang, China.
Environmental science and pollution research international.
2019 Feb; 26(6):5485-5499. doi:
10.1007/s11356-018-4026-3. [PMID: 30610581] - Joseph George, Mikihiro Tsutsumi, Mutsumi Tsuchishima. Alteration of Trace Elements during Pathogenesis of N-Nitrosodimethylamine Induced Hepatic Fibrosis.
Scientific reports.
2019 01; 9(1):708. doi:
10.1038/s41598-018-37516-4. [PMID: 30679730] - Varsha Rani, Yeshvandra Verma, Kavita Rana, Suresh Vir Singh Rana. Zinc oxide nanoparticles inhibit dimethylnitrosamine induced liver injury in rat.
Chemico-biological interactions.
2018 Nov; 295(?):84-92. doi:
10.1016/j.cbi.2017.10.009. [PMID: 29024620] - Bryan Trussell, Shane Trussell, Yan Qu, Fred Gerringer, Sangam Stanczak, Teresa Venezia, Israel Monroy, Fernanda Bacaro, Rhodes Trussell. A four-year simulation of soil aquifer treatment using columns filled with San Gabriel Valley sand.
Water research.
2018 11; 144(?):26-35. doi:
10.1016/j.watres.2018.07.012. [PMID: 30014976] - Li-Rui Tang, Yan-Yan Tao, Cheng-Hai Liu, Hai-Nan Wang. Salvianolate Reduces Glucose Metabolism Disorders in Dimethylnitrosamine-Induced Cirrhotic Rats.
Chinese journal of integrative medicine.
2018 Sep; 24(9):661-669. doi:
10.1007/s11655-017-2773-5. [PMID: 29209957] - Shiow-Chyn Huang, Pei-Wen Wang, Ping-Chung Kuo, Hsin-Yi Hung, Tai-Long Pan. Hepatoprotective Principles and Other Chemical Constituents from the Mycelium of Phellinus linteus.
Molecules (Basel, Switzerland).
2018 Jul; 23(7):. doi:
10.3390/molecules23071705. [PMID: 30002357] - Hiroyuki Oka, Koichi Masuno, Takeki Uehara, Toru Okamoto, Yoshiharu Matsuura, Toru Nakano, Shinpei Yamaguchi. Novel miRNA biomarkers for genotoxicity screening in mouse.
Toxicology.
2018 07; 404-405(?):68-75. doi:
10.1016/j.tox.2018.05.009. [PMID: 29777724] - Phanawan Tongchang, Jindalak Kumsuvan, Warangkana Na Phatthalung, Chaisri Suksaroj, Aunnop Wongrueng, Charongpun Musikavong. Reduction by enhanced coagulation of dissolved organic nitrogen as a precursor of N-nitrosodimethylamine.
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering.
2018 May; 53(6):583-593. doi:
10.1080/10934529.2018.1428270. [PMID: 29420121] - Joseph George. Determination of selenium during pathogenesis of hepatic fibrosis employing hydride generation and inductively coupled plasma mass spectrometry.
Biological chemistry.
2018 04; 399(5):499-509. doi:
10.1515/hsz-2017-0260. [PMID: 29408794] - Marc Bourgin, Birgit Beck, Marc Boehler, Ewa Borowska, Julian Fleiner, Elisabeth Salhi, Rebekka Teichler, Urs von Gunten, Hansruedi Siegrist, Christa S McArdell. Evaluation of a full-scale wastewater treatment plant upgraded with ozonation and biological post-treatments: Abatement of micropollutants, formation of transformation products and oxidation by-products.
Water research.
2018 02; 129(?):486-498. doi:
10.1016/j.watres.2017.10.036. [PMID: 29190578] - Yuxin Chen, Ziping Zhou, Qigui Mo, Gao Zhou, Youwei Wang. Gallic Acid Attenuates Dimethylnitrosamine-Induced Liver Fibrosis by Alteration of Smad Phosphoisoform Signaling in Rats.
BioMed research international.
2018; 2018(?):1682743. doi:
10.1155/2018/1682743. [PMID: 30627538] - A E Antushevich, A E Antushevich, A N Grebenyuk, D A Khalyutin, A A Yartseva. Experimental Modeling of Alcohol-Induced Liver Cirrhosis in Rats.
Bulletin of experimental biology and medicine.
2018 Jan; 164(3):404-407. doi:
10.1007/s10517-018-4000-6. [PMID: 29308556] - Joseph George, Mikihiro Tsutsumi, Mutsumi Tsuchishima. MMP-13 deletion decreases profibrogenic molecules and attenuates N-nitrosodimethylamine-induced liver injury and fibrosis in mice.
Journal of cellular and molecular medicine.
2017 Dec; 21(12):3821-3835. doi:
10.1111/jcmm.13304. [PMID: 28782260] - Hatice Kiziltas, Suat Ekin, Mahire Bayramoglu, Esvet Akbas, Gokhan Oto, Serkan Yildirim, Fevzi Ozgokce. Antioxidant properties of Ferulago angulata and its hepatoprotective effect against N-nitrosodimethylamine-induced oxidative stress in rats.
Pharmaceutical biology.
2017 Dec; 55(1):888-897. doi:
10.1080/13880209.2016.1270974. [PMID: 28142310] - Nahla S El-Shenawy, Reham Z Hamza, Howayda E Khaled. Protective effect of α-lipoic acid against spleen toxicity of dimethylnitrosamine in male mice: Antioxidant and ultrastructure approaches.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Dec; 96(?):459-465. doi:
10.1016/j.biopha.2017.10.010. [PMID: 29031205] - Gbadebo E Adeleke, Oluwatosin A Adaramoye. Betulinic acid protects against N-nitrosodimethylamine-induced redox imbalance in testes of rats.
Redox report : communications in free radical research.
2017 Nov; 22(6):556-562. doi:
10.1080/13510002.2017.1322750. [PMID: 28475470] - Akika Fukawa, Orie Kobayashi, Makoto Yamaguchi, Masayuki Uchida, Akira Hosono. Bovine milk-derived α-lactalbumin prevents hepatic fibrosis induced by dimethylnitrosamine via nitric oxide pathway in rats.
Bioscience, biotechnology, and biochemistry.
2017 Oct; 81(10):1941-1947. doi:
10.1080/09168451.2017.1356215. [PMID: 28752795] - G E Adeleke, O A Adaramoye. Modulatory role of betulinic acid in N-nitrosodimethylamine-induced hepatorenal toxicity in male Wistar rats.
Human & experimental toxicology.
2017 Jul; 36(7):734-743. doi:
10.1177/0960327116661399. [PMID: 27492479] - Xiujie Liu, Jing Su, Yu Shi, Ying Guo, Imran Suheryani, Shicong Zhao, Yulin Deng, Weiwei Meng, Yan Chen, Lili Sun, Rongji Dai. Herbal Formula, Baogan Yihao (BGYH), Prevented Dimethylnitrosamine(DMN)-Induced Liver Injury in Rats.
Drug development research.
2017 06; 78(3-4):155-163. doi:
10.1002/ddr.21388. [PMID: 28524372] - Ni Shi, Fang Chen, Xiaoli Zhang, Steven K Clinton, Xiaofei Tang, Zheng Sun, Tong Chen. Suppression of Oxidative Stress and NFκB/MAPK Signaling by Lyophilized Black Raspberries for Esophageal Cancer Prevention in Rats.
Nutrients.
2017 Apr; 9(4):. doi:
10.3390/nu9040413. [PMID: 28441719] - Anas Shamsi, Azaj Ahmed, Bilqees Bano. Structural transition of kidney cystatin in dimethylnitrosamine-induced renal cancer in rats: identification as a novel biomarker for kidney cancer and prognosis.
Journal of biomolecular structure & dynamics.
2017 Apr; 35(5):1020-1029. doi:
10.1080/07391102.2016.1166988. [PMID: 26982119] - Reham Z Hamza, Hayat A A Ismail, Nahla S El-Shenawy. Oxidative stress, histopathological and electron microscopic alterations induced by dimethylnitrosamine in renal male mice and the protective effect of α-lipoic acid.
Journal of basic and clinical physiology and pharmacology.
2017 Mar; 28(2):149-158. doi:
10.1515/jbcpp-2016-0042. [PMID: 27701137] - A Thirupathi, P C Silveira, R T Nesi, R A Pinho. β-Amyrin, a pentacyclic triterpene, exhibits anti-fibrotic, anti-inflammatory, and anti-apoptotic effects on dimethyl nitrosamine-induced hepatic fibrosis in male rats.
Human & experimental toxicology.
2017 Feb; 36(2):113-122. doi:
10.1177/0960327116638727. [PMID: 27009110] - Hiroshi Matsumoto, Fumiyo Saito, Masahiro Takeyoshi. Investigation of the early-response genes in chemical-induced renal carcinogenicity for the prediction of chemical carcinogenicity in rats.
The Journal of toxicological sciences.
2017; 42(2):175-181. doi:
10.2131/jts.42.175. [PMID: 28321044] - Yang Cheng, Jing-Yin Mai, Mei-Feng Wang, Gao-Feng Chen, Jian Ping. Antifibrotic effect of total flavonoids of Astmgali Radix on dimethylnitrosamine-induced liver cirrhosis in rats.
Chinese journal of integrative medicine.
2017 Jan; 23(1):48-54. doi:
10.1007/s11655-016-2627-6. [PMID: 27787720] - I-Chen Wu, Yu-Kuei Chen, Chun-Chieh Wu, Yu-Jen Cheng, Wei-Chung Chen, Huey-Jiun Ko, Yu-Peng Liu, Chee-Yin Chai, Hung-Shun Lin, Deng-Chyang Wu, Ming-Tsang Wu. Overexpression of ATPase Na+/+ transporting alpha 1 polypeptide, ATP1A1, correlates with clinical diagnosis and progression of esophageal squamous cell carcinoma.
Oncotarget.
2016 Dec; 7(51):85244-85258. doi:
10.18632/oncotarget.13267. [PMID: 27845894] - Myung-Joo Choi, Hong-Mei Zheng, Jae Min Kim, Kye Wan Lee, Yu Hwa Park, Don Haeng Lee. Protective effects of Centella asiatica leaf extract on dimethylnitrosamine‑induced liver injury in rats.
Molecular medicine reports.
2016 Nov; 14(5):4521-4528. doi:
10.3892/mmr.2016.5809. [PMID: 27748812] - Yi-Wen Huang, Fei Gu, Alan Dombkowski, Li-Shu Wang, Gary D Stoner. Black raspberries demethylate Sfrp4, a WNT pathway antagonist, in rat esophageal squamous cell papilloma.
Molecular carcinogenesis.
2016 Nov; 55(11):1867-1875. doi:
10.1002/mc.22435. [PMID: 27696538] - Julian Mamo, Sara Insa, Hèctor Monclús, Ignasi Rodríguez-Roda, Joaquim Comas, Damià Barceló, Maria José Farré. Fate of NDMA precursors through an MBR-NF pilot plant for urban wastewater reclamation and the effect of changing aeration conditions.
Water research.
2016 10; 102(?):383-393. doi:
10.1016/j.watres.2016.06.057. [PMID: 27393963] - Yuping Zhou, Xin Tong, Shuang Ren, Xiaoling Wang, Jiamei Chen, Yongping Mu, Mingyu Sun, Gaofeng Chen, Hua Zhang, Ping Liu. Synergistic anti-liver fibrosis actions of total astragalus saponins and glycyrrhizic acid via TGF-β1/Smads signaling pathway modulation.
Journal of ethnopharmacology.
2016 Aug; 190(?):83-90. doi:
10.1016/j.jep.2016.06.011. [PMID: 27282665] - Maria José Farré, Sara Insa, Julian Mamo, Damià Barceló. Determination of 15 N-nitrosodimethylamine precursors in different water matrices by automated on-line solid-phase extraction ultra-high-performance-liquid chromatography tandem mass spectrometry.
Journal of chromatography. A.
2016 Aug; 1458(?):99-111. doi:
10.1016/j.chroma.2016.06.064. [PMID: 27373375] - Ya-Nan Song, Gui-Biao Zhang, Yi-Yu Lu, Qi-Long Chen, Li Yang, Zheng-Tao Wang, Ping Liu, Shi-Bing Su. Huangqi decoction alleviates dimethylnitrosamine-induced liver fibrosis: An analysis of bile acids metabolic mechanism.
Journal of ethnopharmacology.
2016 Aug; 189(?):148-56. doi:
10.1016/j.jep.2016.05.040. [PMID: 27196295] - Ning-Li Chai, Xiao-Bin Zhang, Si-Wen Chen, Ke-Xing Fan, En-Qiang Linghu. Umbilical cord-derived mesenchymal stem cells alleviate liver fibrosis in rats.
World journal of gastroenterology.
2016 Jul; 22(26):6036-48. doi:
10.3748/wjg.v22.i26.6036. [PMID: 27468195] - David Hanigan, Xiaobin Liao, Jinwei Zhang, Pierre Herckes, Paul Westerhoff. Sorption and desorption of organic matter on solid-phase extraction media to isolate and identify N-nitrosodimethylamine precursors.
Journal of separation science.
2016 Jul; 39(14):2796-805. doi:
10.1002/jssc.201600139. [PMID: 27184503] - James A Hodgson, Tiffany H Seyler, Lanqing Wang. Long-Term Stability of Volatile Nitrosamines in Human Urine.
Journal of analytical toxicology.
2016 Jul; 40(6):414-8. doi:
10.1093/jat/bkw038. [PMID: 27274026] - Xue-Mei Li, Jing-Hua Peng, Zhao-Lin Sun, Hua-Jie Tian, Xiao-Hua Duan, Lin Liu, Xin Ma, Qin Feng, Ping Liu, Yi-Yang Hu. Chinese medicine CGA formula ameliorates DMN-induced liver fibrosis in rats via inhibiting MMP2/9, TIMP1/2 and the TGF-β/Smad signaling pathways.
Acta pharmacologica Sinica.
2016 Jun; 37(6):783-93. doi:
10.1038/aps.2016.35. [PMID: 27133300] - Teng Zeng, William A Mitch. Oral intake of ranitidine increases urinary excretion of N-nitrosodimethylamine.
Carcinogenesis.
2016 06; 37(6):625-634. doi:
10.1093/carcin/bgw034. [PMID: 26992900] - Shannon L Leavey-Roback, Catherine A Sugar, Stuart W Krasner, Irwin H Mel Suffet. NDMA formation during drinking water treatment: A multivariate analysis of factors influencing formation.
Water research.
2016 05; 95(?):300-9. doi:
10.1016/j.watres.2016.02.060. [PMID: 27015632] - Guo-Yuan Gao, Xi-Yuan Zheng, Yuan Peng, Yan-Yan Tao, Ping Liu, Tao Yang, Cheng-Hai Liu. [Effect of Fuzheng Huayu capsule on serum metabolomics in rats with liver fibrosis induced by dimethylnitrosamine].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2016 May; 41(9):1725-1731. doi:
10.4268/cjcmm20160925. [PMID: 28891625] - Kyoung Ook Cheong, Dong-Su Shin, Jeonghyeon Bak, Changyong Lee, Kyung Wook Kim, Nam Kyung Je, Hae Young Chung, Sik Yoon, Jeon-Ok Moon. Hepatoprotective effects of zingerone on carbon tetrachloride- and dimethylnitrosamine-induced liver injuries in rats.
Archives of pharmacal research.
2016 Feb; 39(2):279-291. doi:
10.1007/s12272-015-0696-2. [PMID: 26667466] - X Zhang, J Zhang, L Jia, S Xiao. Dicliptera Chinensis polysaccharides target TGF-β/Smad pathway and inhibit stellate cells activation in rats with dimethylnitrosamine-induced hepatic fibrosis.
Cellular and molecular biology (Noisy-le-Grand, France).
2016 Jan; 62(1):99-103. doi:
". [PMID: 26828995] - Hye-Jung Park, Hyeong-Geug Kim, Jing-Hua Wang, Min-Kyung Choi, Jong-Min Han, Jin-Seok Lee, Chang-Gue Son. Comparison of TGF-β, PDGF, and CTGF in hepatic fibrosis models using DMN, CCl4, and TAA.
Drug and chemical toxicology.
2016; 39(1):111-8. doi:
10.3109/01480545.2015.1052143. [PMID: 26045230] - Devaraj Ezhilarasan, Sivanesan Karthikeyan. Silibinin alleviates N-nitrosodimethylamine-induced glutathione dysregulation and hepatotoxicity in rats.
Chinese journal of natural medicines.
2016 Jan; 14(1):40-7. doi:
10.3724/sp.j.1009.2016.00040. [PMID: 26850345] - Chengkun Wang, Shuming Liu, Jun Wang, Xiaojian Zhang, Chao Chen. Monthly survey of N-nitrosamine yield in a conventional water treatment plant in North China.
Journal of environmental sciences (China).
2015 Dec; 38(?):142-9. doi:
10.1016/j.jes.2015.05.025. [PMID: 26702978] - Cheng Liu, Zongguo Yang, Lei Wang, Yunfei Lu, Bozong Tang, Hui Miao, Qingnian Xu, Xiaorong Chen. Combination of sorafenib and gadolinium chloride (GdCl3) attenuates dimethylnitrosamine(DMN)-induced liver fibrosis in rats.
BMC gastroenterology.
2015 Nov; 15(?):159. doi:
10.1186/s12876-015-0380-5. [PMID: 26572488] - Wenhui Gan, Tom Bond, Xin Yang, Paul Westerhoff. Role of Chlorine Dioxide in N-Nitrosodimethylamine Formation from Oxidation of Model Amines.
Environmental science & technology.
2015 Oct; 49(19):11429-37. doi:
10.1021/acs.est.5b01729. [PMID: 26335270] - De-Jiang Zhou, Dong Mu, Ming-De Jiang, Shu-Mei Zheng, Yong Zhang, Sheng He, Min Weng, Wei-Zheng Zeng. Hepatoprotective effect of juglone on dimethylnitrosamine-induced liver fibrosis and its effect on hepatic antioxidant defence and the expression levels of α-SMA and collagen III.
Molecular medicine reports.
2015 Sep; 12(3):4095-4102. doi:
10.3892/mmr.2015.3992. [PMID: 26126609] - Sharad S Singhal, Jyotsana Singhal, James L Figarola, Arthur Riggs, David Horne, Sanjay Awasthi. 2'-Hydroxyflavanone: A promising molecule for kidney cancer prevention.
Biochemical pharmacology.
2015 Aug; 96(3):151-8. doi:
10.1016/j.bcp.2015.04.022. [PMID: 25957660] - Tai-Long Pan, Pei-Wen Wang, Chun-Hsun Huang, Yann-Lii Leu, Tung-Ho Wu, Yun-Ru Wu, Jyh-Sheng You. Herbal formula, Scutellariae radix and Rhei rhizoma attenuate dimethylnitrosamine-induced liver fibrosis in a rat model.
Scientific reports.
2015 Jul; 5(?):11734. doi:
10.1038/srep11734. [PMID: 26133262] - Monthana Weerawatanakorn, You-Li Lee, Chen-Yu Tsai, Ching-Shu Lai, Xiaochun Wan, Chi-Tang Ho, Shiming Li, Min-Hsiung Pan. Protective effect of theaflavin-enriched black tea extracts against dimethylnitrosamine-induced liver fibrosis in rats.
Food & function.
2015 Jun; 6(6):1832-40. doi:
10.1039/c5fo00126a. [PMID: 25927469] - Mu-Rong Chao, Yu-Wen Hsu, Hung-Hsin Liu, Jia-Hong Lin, Chiung-Wen Hu. Simultaneous Detection of 3-Nitrotyrosine and 3-Nitro-4-hydroxyphenylacetic Acid in Human Urine by Online SPE LC-MS/MS and Their Association with Oxidative and Methylated DNA Lesions.
Chemical research in toxicology.
2015 May; 28(5):997-1006. doi:
10.1021/acs.chemrestox.5b00031. [PMID: 25825822] - Nora Baberschke, Christian E W Steinberg, Nadine Saul. Low concentrations of dibromoacetic acid and N-nitrosodimethylamine induce several stimulatory effects in the invertebrate model Caenorhabditis elegans.
Chemosphere.
2015 Apr; 124(?):122-8. doi:
10.1016/j.chemosphere.2014.12.002. [PMID: 25556763] - Ronglu Dong, Shizhuang Weng, Liangbao Yang, Jinhuai Liu. Detection and direct readout of drugs in human urine using dynamic surface-enhanced Raman spectroscopy and support vector machines.
Analytical chemistry.
2015 Mar; 87(5):2937-44. doi:
10.1021/acs.analchem.5b00137. [PMID: 25634247] - Habibullah Uzun, Daekyun Kim, Tanju Karanfil. Seasonal and temporal patterns of NDMA formation potentials in surface waters.
Water research.
2015 Feb; 69(?):162-172. doi:
10.1016/j.watres.2014.11.017. [PMID: 25481075] - Koji Kosaka, Mari Asami, Keiko Ohkubo, Michihiro Akiba. Determination of a N-Nitrosodimethylamine Precursor in Water Using Ultra-high Performance Liquid Chromatography-Tandem Mass Spectrometry.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2015; 31(8):769-72. doi:
10.2116/analsci.31.769. [PMID: 26256599] - Shu Yan, Shuxia Tian, Qingwei Kang, Yafei Xia, Caixia Li, Qing Chen, Shukun Zhang, Zhigang Li. Rhizoma Paridis Saponins Suppresses Tumor Growth in a Rat Model of N-Nitrosomethylbenzylamine-Induced Esophageal Cancer by Inhibiting Cyclooxygenases-2 Pathway.
PloS one.
2015; 10(7):e0131560. doi:
10.1371/journal.pone.0131560. [PMID: 26147856] - Unji Lee, Euichaul Oh. Pharmacokinetic changes of drugs in a rat model of liver cirrhosis induced by dimethylnitrosamine, alone and in combination with diabetes mellitus induced by streptozotocin.
Biopharmaceutics & drug disposition.
2015 Jan; 36(1):1-14. doi:
10.1002/bdd.1901. [PMID: 24861008] - V P Deriagina, N I Ryzhova, L V Krivosheeva, I S Golubeva. [Production of nitric oxide metabolites during transplanted tumors growth with different metastatic potential].
Biomeditsinskaia khimiia.
2014 Nov; 60(6):661-7. doi:
10.18097/pbmc20146006661. [PMID: 25552506] - Koji Kosaka, Mari Asami, Keiko Ohkubo, Takuji Iwamoto, Yasuo Tanaka, Hiroyuki Koshino, Shinya Echigo, Michihiro Akiba. Identification of a new N-nitrosodimethylamine precursor in sewage containing industrial effluents.
Environmental science & technology.
2014 Oct; 48(19):11243-50. doi:
10.1021/es502284t. [PMID: 25184404] - Kanta Jobara, Toshimi Kaido, Tomohide Hori, Keiko Iwaisako, Kosuke Endo, Yoichiro Uchida, Shinji Uemoto. Whey-hydrolyzed peptide-enriched immunomodulating diet prevents progression of liver cirrhosis in rats.
Nutrition (Burbank, Los Angeles County, Calif.).
2014 Oct; 30(10):1195-207. doi:
10.1016/j.nut.2014.02.005. [PMID: 24976428] - Ki-Suk Kim, Hea Jung Yang, Jae-Youl Lee, Yun-Cheol Na, Soo-Young Kwon, Young-Chul Kim, Jang-Hoon Lee, Hyeung-Jin Jang. Effects of β-sitosterol derived from Artemisia capillaris on the activated human hepatic stellate cells and dimethylnitrosamine-induced mouse liver fibrosis.
BMC complementary and alternative medicine.
2014 Sep; 14(?):363. doi:
10.1186/1472-6882-14-363. [PMID: 25262005] - Areeba Ahmad, Riaz Ahmad. Resveratrol mitigate structural changes and hepatic stellate cell activation in N'-nitrosodimethylamine-induced liver fibrosis via restraining oxidative damage.
Chemico-biological interactions.
2014 Sep; 221(?):1-12. doi:
10.1016/j.cbi.2014.07.007. [PMID: 25064540] - Massimiliano Sgroi, Paolo Roccaro, Gregg L Oelker, Shane A Snyder. N-nitrosodimethylamine formation upon ozonation and identification of precursors source in a municipal wastewater treatment plant.
Environmental science & technology.
2014 Sep; 48(17):10308-15. doi:
10.1021/es5011658. [PMID: 25029629] - Xinyan Zhu, Ruilin Liu, Dapeng Kuang, Jingqi Liu, Xiaomeng Shi, Tingting Zhang, Yu Zeng, Xianghua Sun, Yi Zhang, Wenzhuo Yang. The role of phospholipase D1 in liver fibrosis induced by dimethylnitrosamine in vivo.
Digestive diseases and sciences.
2014 Aug; 59(8):1779-88. doi:
10.1007/s10620-014-3130-6. [PMID: 24728967] - Chao Chen, Shannon Leavey, Stuart W Krasner, I H Mel Suffet. Applying polarity rapid assessment method and ultrafiltration to characterize NDMA precursors in wastewater effluents.
Water research.
2014 Jun; 57(?):115-26. doi:
10.1016/j.watres.2014.02.052. [PMID: 24709532] - Shujuan Zhang, Jun Wu, Hua Wang, Tiechuang Wang, Lina Jin, Dandan Shu, Weiguang Shan, Subin Xiong. Liposomal oxymatrine in hepatic fibrosis treatment: formulation, in vitro and in vivo assessment.
AAPS PharmSciTech.
2014 Jun; 15(3):620-9. doi:
10.1208/s12249-014-0086-y. [PMID: 24515270] - Daniel S Peiffer, Noah P Zimmerman, Li-Shu Wang, Benjamin W S Ransom, Steven G Carmella, Chieh-Ti Kuo, Jibran Siddiqui, Jo-Hsin Chen, Kiyoko Oshima, Yi-Wen Huang, Stephen S Hecht, Gary D Stoner. Chemoprevention of esophageal cancer with black raspberries, their component anthocyanins, and a major anthocyanin metabolite, protocatechuic acid.
Cancer prevention research (Philadelphia, Pa.).
2014 Jun; 7(6):574-84. doi:
10.1158/1940-6207.capr-14-0003. [PMID: 24667581] - Shimaa M Elshazly, Amr A A Mahmoud. Antifibrotic activity of hesperidin against dimethylnitrosamine-induced liver fibrosis in rats.
Naunyn-Schmiedeberg's archives of pharmacology.
2014 Jun; 387(6):559-67. doi:
10.1007/s00210-014-0968-2. [PMID: 24627177] - Xi-Yuan Zheng, Ying-Fan Yang, Wan Li, Xin Zhao, Yi Sun, Hua Sun, Yue-Hua Wang, Xiao-Ping Pu. Two xanthones from Swertia punicea with hepatoprotective activities in vitro and in vivo.
Journal of ethnopharmacology.
2014 May; 153(3):854-63. doi:
10.1016/j.jep.2014.03.058. [PMID: 24690777] - N V Zaytseva, T S Ulanova, T V Nurislamova, N A Popova. [The elaboration of gas chromatographic method of the determination of N-nitrosamines (N-nitrosodimethylamine, N-nitrosodiethylamine) in biological samples (urine)].
Gigiena i sanitariia.
2014 May; ?(3):88-92. doi:
NULL. [PMID: 25306711] - Yong-Hong Wang, Chen-Xi Zhao, Ben-Mei Chen, Min He, Lin-Qi Liu, Chun-Yan Li, Xin Chen. [Reverse effect of Yinchenhao decoction in dimethyl nitrosamine-induced hepatic fibrosis in rats].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2014 Apr; 39(8):1473-8. doi:
. [PMID: 25039185] - Adriana Nowak, Sławomir Kuberski, Zdzisława Libudzisz. Probiotic lactic acid bacteria detoxify N-nitrosodimethylamine.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.
2014; 31(10):1678-87. doi:
10.1080/19440049.2014.943304. [PMID: 25010287] - James M Mathews, Scott L Watson, Purvi R Patel, Sherry R Black, Yan Hong, Keith E Levine, Glenn Ross, Dori R Germolec, Sheetal A Thakur, Suramya Waidyanatha. Metabolism and disposition of [(14)C]dimethylamine borane in male Harlan Sprague Dawley rats following gavage administration, intravenous administration and dermal application.
Xenobiotica; the fate of foreign compounds in biological systems.
2014 Jan; 44(1):36-47. doi:
10.3109/00498254.2013.800662. [PMID: 23786350] - Shu-Chen Chien, Wei-Chiao Chang, Pu-Hua Lin, Wei-Pin Chang, Shih-Chung Hsu, Jung-Chen Chang, Ya-Chieh Wu, Jin-Kuo Pei, Chia-Hsien Lin. A Chinese herbal medicine, jia-wei-xiao-yao-san, prevents dimethylnitrosamine-induced hepatic fibrosis in rats.
TheScientificWorldJournal.
2014; 2014(?):217525. doi:
10.1155/2014/217525. [PMID: 24995353]