Ginkgolide B (BioDeep_00000002929)
human metabolite PANOMIX_OTCML-2023 Endogenous
代谢物信息卡片
(1R,3R,8S,10R,13S,16S,17R)-8-tert-butyl-6,12,17-trihydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.01,11.03,7.07,11.013,17]nonadecane-5,15,18-trione
化学式: C20H24O10 (424.1369)
中文名称: 银杏内酯B
谱图信息:
最多检出来源 Viridiplantae(plant) 24.56%
分子结构信息
SMILES: CC1C(=O)OC2C(O)C34C5CC(C(C)(C)C)C33C(O)C(=O)OC3OC4(C(=O)O5)C12O
InChI: InChI=1S/C20H24O10/c1-6-12(23)28-11-9(21)18-8-5-7(16(2,3)4)17(18)10(22)13(24)29-15(17)30-20(18,14(25)27-8)19(6,11)26/h6-11,15,21-22,26H,5H2,1-4H3
描述信息
Ginkgolide B is found in fats and oils. Ginkgolide B is isolated from Ginkgo biloba (ginkgo).
Isolated from Ginkgo biloba (ginkgo). Ginkgolide B is found in ginkgo nuts and fats and oils.
D006401 - Hematologic Agents > D005343 - Fibrinolytic Agents
D050299 - Fibrin Modulating Agents
D002317 - Cardiovascular Agents
Ginkgolide B (BN-52021) is a terpenoid and one of the important active substances in Ginkgo leaves.
Ginkgolide B (BN-52021) is a terpenoid and one of the important active substances in Ginkgo leaves.
同义名列表
10 个代谢物同义名
(1R,3R,8S,10R,13S,16S,17R)-8-tert-butyl-6,12,17-trihydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.01,11.03,7.07,11.013,17]nonadecane-5,15,18-trione; 8-tert-butyl-6,12,17-trihydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.0¹,¹¹.0³,⁷.0⁷,¹¹.0¹³,¹⁷]nonadecane-5,15,18-trione; 1-Hydroxy-(1beta)-ginkgolide a; ginkgolide B, (1beta)-isomer; Gingko lactone; Ginkgolide B; Ginkolide B; BN52021; BN-52021; Ginkgolide B
数据库引用编号
22 个数据库交叉引用编号
- KEGG: C07602
- PubChem: 441294
- PubChem: 65243
- HMDB: HMDB0036861
- Metlin: METLIN41245
- ChEMBL: CHEMBL266625
- Wikipedia: Ginkgolide
- KNApSAcK: C00035830
- foodb: FDB015815
- chemspider: 58739
- CAS: 99796-69-7
- CAS: 15291-77-7
- PMhub: MS000007126
- ChEBI: CHEBI:5356
- PubChem: 9804
- LipidMAPS: LMPR0104540002
- 3DMET: B05251
- NIKKAJI: J39.135B
- medchemexpress: HY-N0784
- KNApSAcK: 5356
- LOTUS: LTS0143295
- wikidata: Q105258345
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
6 个相关的物种来源信息
- 3310 - Ginkgo: 10.1016/J.PHYTOCHEM.2004.08.026
- 3311 - Ginkgo biloba:
- 3311 - Ginkgo biloba: -
- 3311 - Ginkgo biloba L.: -
- 9606 - Homo sapiens: -
- 33090 - Plants: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Thelma Akanchise, Borislav Angelov, Angelina Angelova. Nanomedicine-mediated recovery of antioxidant glutathione peroxidase activity after oxidative-stress cellular damage: Insights for neurological long COVID.
Journal of medical virology.
2024 May; 96(5):e29680. doi:
10.1002/jmv.29680. [PMID: 38767144] - M A Berezutsky, N A Durnova, T A Andronova. [Ginkgolide B: mechanisms of neurobiological effects, prospects for use in the therapy of Alzheimer's disease].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova.
2024; 124(4):22-27. doi:
10.17116/jnevro202412404122. [PMID: 38676673] - Yun Liu, Chungang Zhang, Lan Cheng, Hongxin Wang, Meili Lu, Hengyu Xu. Enhancing both oral bioavailability and anti-ischemic stroke efficacy of ginkgolide B by preparing nanocrystals self-stabilized Pickering nano-emulsion.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2023 Oct; ?(?):106620. doi:
10.1016/j.ejps.2023.106620. [PMID: 37871688] - Aiming Chen, Jun Hua, Jun Yuan, Yajuan Feng, Fengzhan Chen, Yongqin Zhou, Ting Han, Weiwei Jiang, Huiping Chen. Ginkgolide B promotes spontaneous recovery and enhances endogenous netrin-1 after neonatal hypoxic-ischemic brain damage.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience.
2023 Sep; ?(?):. doi:
10.1002/jdn.10301. [PMID: 37771243] - Yuwei Yang, Qing Wu, Xin Shan, Haiyan Zhou, Jinwen Wang, Yue Hu, Jing Chen, Zhiyang Lv. Ginkgolide B attenuates cerebral ischemia-reperfusion injury via inhibition of ferroptosis through disrupting NCOA4-FTH1 interaction.
Journal of ethnopharmacology.
2023 Jul; ?(?):116982. doi:
10.1016/j.jep.2023.116982. [PMID: 37532074] - Eun-Joo Shin, Bao Trong Nguyen, Naveen Sharma, Ngoc Kim Cuong Tran, Yen Nhi Doan Nguyen, Yeonggwang Hwang, Jung Hoon Park, Seung-Yeol Nah, Sung Kwon Ko, Jae Kyung Byun, Yi Lee, Dae-Joong Kim, Ji Hoon Jeong, Hyoung-Chun Kim. Ginsenoside Re mitigates memory impairments in aged GPx-1 KO mice by inhibiting the interplay between PAFR, NFκB, and microgliosis in the hippocampus.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2023 Mar; 173(?):113627. doi:
10.1016/j.fct.2023.113627. [PMID: 36682417] - Lars Wiklund, Aruna Sharma, Dafin F Muresanu, Zhiqiang Zhang, Cong Li, Z Ryan Tian, Anca D Buzoianu, José Vicente Lafuente, Ala Nozari, Lianyuan Feng, Hari Shanker Sharma. TiO2-Nanowired Delivery of Chinese Extract of Ginkgo biloba EGb-761 and Bilobalide BN-52021 Enhanced Neuroprotective Effects of Cerebrolysin Following Spinal Cord Injury at Cold Environment.
Advances in neurobiology.
2023; 32(?):353-384. doi:
10.1007/978-3-031-32997-5_9. [PMID: 37480466] - Jing Chen, Zhijie Ou, Tiantian Gao, Yuwei Yang, Anmei Shu, Huiqin Xu, Yuping Chen, Zhiyang Lv. Ginkgolide B alleviates oxidative stress and ferroptosis by inhibiting GPX4 ubiquitination to improve diabetic nephropathy.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Dec; 156(?):113953. doi:
10.1016/j.biopha.2022.113953. [PMID: 36411664] - Dake Cai, Zhongxing Luo, Jiyan Su, Haining Gan, Zhi Wang, Xiaolin Liu, Siyi Li, Jingjing Wu, Jiangying Chen, Renqiang Ma, Min Huang, Guoping Zhong. Exposure-Response Analysis and Mechanism of Ginkgolide B's Neuroprotective Effect in Acute Cerebral Ischemia/Reperfusion Stage in Rat.
Biological & pharmaceutical bulletin.
2022; 45(4):409-420. doi:
10.1248/bpb.b21-00781. [PMID: 35370265] - Jing Wang, Linwu Zhuang, Yan Ding, Zhenzhong Wang, Wei Xiao, Jingbo Zhu. A RNA-seq approach for exploring the protective effect of ginkgolide B on glutamate-induced astrocytes injury.
Journal of ethnopharmacology.
2021 Apr; 270(?):113807. doi:
10.1016/j.jep.2021.113807. [PMID: 33450290] - Yousong Li, Jinsheng Gao, Xi Yang, Tao Li, Baoxue Yang, Aixingzi Aili. Combination of curcumin and ginkgolide B inhibits cystogenesis by regulating multiple signaling pathways.
Molecular medicine reports.
2021 03; 23(3):. doi:
10.3892/mmr.2021.11834. [PMID: 33495815] - Zhiyang Lv, Xin Shan, Qingbo Tu, Jie Wang, Jing Chen, Yuwei Yang. Ginkgolide B treatment regulated intestinal flora to improve high-fat diet induced atherosclerosis in ApoE-/- mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Feb; 134(?):111100. doi:
10.1016/j.biopha.2020.111100. [PMID: 33341056] - Seaab Sahib, Aruna Sharma, Dafin F Muresanu, Zhiqiang Zhang, Cong Li, Z Ryan Tian, Anca D Buzoianu, José Vicente Lafuente, Rudy J Castellani, Ala Nozari, Ranjana Patnaik, Preeti K Menon, Lars Wiklund, Hari Shanker Sharma. Nanodelivery of traditional Chinese Gingko Biloba extract EGb-761 and bilobalide BN-52021 induces superior neuroprotective effects on pathophysiology of heat stroke.
Progress in brain research.
2021; 265(?):249-315. doi:
10.1016/bs.pbr.2021.06.007. [PMID: 34560923] - Yuwei Yang, Jing Chen, Qin Gao, Xin Shan, Jie Wang, Zhiyang Lv. Study on the attenuated effect of Ginkgolide B on ferroptosis in high fat diet induced nonalcoholic fatty liver disease.
Toxicology.
2020 12; 445(?):152599. doi:
10.1016/j.tox.2020.152599. [PMID: 32976958] - Yijin Xiang, Shaoyan Zhang, Jia Lu, Wen Zhang, Min Cai, Jun Xiang, Dingfang Cai. Ginkgolide B protects human pulmonary alveolar epithelial A549 cells from lipopolysaccharide-induced inflammatory responses by reducing TRIM37-mediated NF-κB activation.
Biotechnology and applied biochemistry.
2020 Nov; 67(6):903-911. doi:
10.1002/bab.1847. [PMID: 31691373] - Wang Jing, Zhu Jun-Jun, Shen Bao-de, Zhang Ting, Dai Bo, Zhu Ya-Ning, Yuan Hai-Long. [Preparation and quality evaluation of orodispersible film containing ginkgolide B novel nanosuspension lyophilized powder].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2020 Nov; 45(22):5504-5510. doi:
10.19540/j.cnki.cjcmm.20200819.306. [PMID: 33350212] - Jin Liu, Peng Wu, Zhihui Xu, Jun Zhang, Jiabao Liu, Zhijian Yang. Ginkgolide B inhibits hydrogen peroxide‑induced apoptosis and attenuates cytotoxicity via activating the PI3K/Akt/mTOR signaling pathway in H9c2 cells.
Molecular medicine reports.
2020 07; 22(1):310-316. doi:
10.3892/mmr.2020.11099. [PMID: 32377729] - Xuan Wang, Qi-Hui Shao, Hao Zhou, Jun-Lu Wu, Wen-Qiang Quan, Ping Ji, Yi-Wen Yao, Dong Li, Zu-Jun Sun. Ginkgolide B inhibits lung cancer cells promotion via beclin-1-dependent autophagy.
BMC complementary medicine and therapies.
2020 Jun; 20(1):194. doi:
10.1186/s12906-020-02980-x. [PMID: 32576183] - Dezhi Ren, Fang Li, An Gao, Qingwen Cao, Yarong Liu, Junru Zhang. Hypoxia-induced apoptosis of cardiomyocytes is restricted by ginkgolide B-downregulated microRNA-29.
Cell cycle (Georgetown, Tex.).
2020 05; 19(10):1067-1076. doi:
10.1080/15384101.2020.1731651. [PMID: 32295500] - Jing Wang, Jun-Jun Zhu, Bao-de Shen, Ting Zhang, Ya-Ning Zhu, Hai-Long Yuan. [Preparation and in vitro release of ginkgolide B nanosuspension].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2020 Apr; 45(7):1657-1663. doi:
10.19540/j.cnki.cjcmm.20200207.306. [PMID: 32489046] - Shohei Nishimon, Mai Yamaguchi, Hisae Muraki, Noriaki Sakai, Seiji Nishino. Intraperitoneal injection of ginkgolide B, a major active compound of Ginkgo biloba, dose-dependently increases the amount of wake and decreases non-rapid eye movement sleep in C57BL/6 mice.
Neuroscience letters.
2020 03; 722(?):134832. doi:
10.1016/j.neulet.2020.134832. [PMID: 32050100] - Yao Liu, Wei Liu, Sha Xiong, Jingshan Luo, Ye Li, Yuying Zhao, Qun Wang, Zexin Zhang, Xiaojia Chen, Tongkai Chen. Highly stabilized nanocrystals delivering Ginkgolide B in protecting against the Parkinson's disease.
International journal of pharmaceutics.
2020 Mar; 577(?):119053. doi:
10.1016/j.ijpharm.2020.119053. [PMID: 31981707] - Chenlin Shen, Xiaoqin Jin, Maomao Wu, Xiaohui Huang, Jun Li, Hong Huang, Feilong Li, Jiatao Liu, Genxiang Rong, Shuai Song. A sensitive LC-MS/MS method to determine ginkgolide B in human plasma and urine: application in a pharmacokinetics and excretion study of healthy Chinese subjects.
Xenobiotica; the fate of foreign compounds in biological systems.
2020 Mar; 50(3):323-331. doi:
10.1080/00498254.2019.1612124. [PMID: 31088195] - Yuying Zhao, Sha Xiong, Piaoxue Liu, Wei Liu, Qun Wang, Yao Liu, Hanxu Tan, Xiaojia Chen, Xuguang Shi, Qi Wang, Tongkai Chen. Polymeric Nanoparticles-Based Brain Delivery with Improved Therapeutic Efficacy of Ginkgolide B in Parkinson's Disease.
International journal of nanomedicine.
2020; 15(?):10453-10467. doi:
10.2147/ijn.s272831. [PMID: 33380795] - Haihua Zhang, Qiumei Shi, Weixiao Nan, Yaqi Wang, Shiyong Wang, Fuhe Yang, Guangyu Li. Ginkgolide B and bilobalide promote the growth and increase β-catenin expression in hair follicle dermal papilla cells of American minks.
BioFactors (Oxford, England).
2019 Nov; 45(6):950-958. doi:
10.1002/biof.1562. [PMID: 31520488] - Dalal G Al-Adwani, Waleed M Renno, Khaled Y Orabi. Neurotherapeutic effects of Ginkgo biloba extract and its terpene trilactone, ginkgolide B, on sciatic crush injury model: A new evidence.
PloS one.
2019; 14(12):e0226626. doi:
10.1371/journal.pone.0226626. [PMID: 31877172] - Gang Wang, Zhenbin Liu, Menghu Li, Yu Li, Sahir Sultan Alvi, Irfan Ahmad Ansari, M Salman Khan. Ginkgolide B Mediated Alleviation of Inflammatory Cascades and Altered Lipid Metabolism in HUVECs via Targeting PCSK-9 Expression and Functionality.
BioMed research international.
2019; 2019(?):7284767. doi:
10.1155/2019/7284767. [PMID: 31281844] - Zhanbin Feng, Xiaofei Yang, Long Zhang, Irfan A Ansari, M Salman Khan, Shuyi Han, Yaoyu Feng. Ginkgolide B ameliorates oxidized low-density lipoprotein-induced endothelial dysfunction via modulating Lectin-like ox-LDL-receptor-1 and NADPH oxidase 4 expression and inflammatory cascades.
Phytotherapy research : PTR.
2018 Dec; 32(12):2417-2427. doi:
10.1002/ptr.6177. [PMID: 30136446] - Wen-Bo Yu, Liang Cao, Yan-Yin Zhao, Wei Xiao, Bao-Guo Xiao. Comparing the role of Ginkgolide B and Ginkgolide K on cultured astrocytes exposed to oxygen‑glucose deprivation.
Molecular medicine reports.
2018 Nov; 18(5):4417-4427. doi:
10.3892/mmr.2018.9450. [PMID: 30221704] - Ming-Yang Li, Chia-Ting Chang, Yueh-Ting Han, Chien-Po Liao, Jenn-Yah Yu, Tsu-Wei Wang. Ginkgolide B promotes neuronal differentiation through the Wnt/β-catenin pathway in neural stem cells of the postnatal mammalian subventricular zone.
Scientific reports.
2018 10; 8(1):14947. doi:
10.1038/s41598-018-32960-8. [PMID: 30297722] - Aiming Chen, Yin Xu, Jun Yuan. Ginkgolide B ameliorates NLRP3 inflammasome activation after hypoxic-ischemic brain injury in the neonatal male rat.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience.
2018 Oct; 69(?):106-111. doi:
10.1016/j.ijdevneu.2018.07.004. [PMID: 30030129] - Xiaohan Yang, Tiezheng Zheng, Hao Hong, Nan Cai, Xiaofeng Zhou, Changkai Sun, Liying Wu, Shuhong Liu, Yongqi Zhao, Lingling Zhu, Ming Fan, Xuezhong Zhou, Fengxie Jin. Neuroprotective effects of Ginkgo biloba extract and Ginkgolide B against oxygen-glucose deprivation/reoxygenation and glucose injury in a new in vitro multicellular network model.
Frontiers of medicine.
2018 Jun; 12(3):307-318. doi:
10.1007/s11684-017-0547-2. [PMID: 29058254] - Lixiang Aa, Fei Fei, Zhaoyi Tan, Jiye Aa, Guangji Wang, Changxiao Liu. The pharmacokinetics study of ginkgolide A, B and the effect of food on bioavailability after oral administration of ginkgolide extracts in beagle dogs.
Biomedical chromatography : BMC.
2018 Jun; 32(6):e4212. doi:
10.1002/bmc.4212. [PMID: 29516538] - Fang-Fang Xu, Yu-An Bi, Wen-Zhe Huang, Zhen-Zhong Wang, Wei Xiao. Applying risk management to analytical methods for the desorbing process of ginkgo diterpene lactone meglumine injection.
Chinese journal of natural medicines.
2018 May; 16(5):366-374. doi:
10.1016/s1875-5364(18)30069-4. [PMID: 29860998] - The-Vinh Tran, Se Jin Park, Eun-Joo Shin, Hai-Quyen Tran, Ji Hoon Jeong, Choon-Gon Jang, Yu Jeung Lee, Seung-Yeol Nah, Toshitaka Nabeshima, Hyoung-Chun Kim. Blockade of platelet-activating factor receptor attenuates abnormal behaviors induced by phencyclidine in mice through down-regulation of NF-κB.
Brain research bulletin.
2018 03; 137(?):71-78. doi:
10.1016/j.brainresbull.2017.11.004. [PMID: 29122692] - Jun Hua, Nuo Yin, Beibei Yang, Ji Zhang, Jianhua Ding, Yi Fan, Gang Hu. Ginkgolide B and bilobalide ameliorate neural cell apoptosis in α-synuclein aggregates.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Dec; 96(?):792-797. doi:
10.1016/j.biopha.2017.10.050. [PMID: 29054095] - Shu-Yao Wang, Ji-Ye A, Fei Fei, Jian-Liang Geng, Ying Peng, Bing-Chen Ouyang, Pei Wang, Xiao-Liang Jin, Yu-Qing Zhao, Jian-Kun Wang, Ting Geng, Yan-Jing Li, Wen-Zhe Huang, Zhen-Zhong Wang, Wei Xiao, Guang-Ji Wang. Pharmacokinetics of the prototype and hydrolyzed carboxylic forms of ginkgolides A, B, and K administered as a ginkgo diterpene lactones meglumine injection in beagle dogs.
Chinese journal of natural medicines.
2017 Oct; 15(10):775-784. doi:
10.1016/s1875-5364(17)30109-7. [PMID: 29103463] - Iqbal Gill, Sukhchain Kaur, Navrattan Kaur, Monisha Dhiman, Anil K Mantha. Phytochemical Ginkgolide B Attenuates Amyloid-β1-42 Induced Oxidative Damage and Altered Cellular Responses in Human Neuroblastoma SH-SY5Y Cells.
Journal of Alzheimer's disease : JAD.
2017; 60(s1):S25-S40. doi:
10.3233/jad-161086. [PMID: 28234255] - R Munoz-Cano, E Ainsua-Enrich, I Torres-Atencio, M Martin, J Sánchez-Lopez, J Bartra, C Picado, J Mullol, A Valero. Effects of Rupatadine on Platelet- Activating Factor-Induced Human Mast Cell Degranulation Compared With Desloratadine and Levocetirizine (The MASPAF Study).
Journal of investigational allergology & clinical immunology.
2017 ; 27(3):161-168. doi:
10.18176/jiaci.0117. [PMID: 27758758] - Hisashi Doi, Kengo Sato, Hideo Shindou, Kengo Sumi, Hiroko Koyama, Takamitsu Hosoya, Yasuyoshi Watanabe, Satoshi Ishii, Hideo Tsukada, Koji Nakanishi, Masaaki Suzuki. Blood-brain barrier permeability of ginkgolide: Comparison of the behavior of PET probes 7α-[18F]fluoro- and 10-O-p-[11C]methylbenzyl ginkgolide B in monkey and rat brains.
Bioorganic & medicinal chemistry.
2016 11; 24(21):5148-5157. doi:
10.1016/j.bmc.2016.08.032. [PMID: 27614918] - Shuyao Wang, Bingchen Ouyang, Jiye Aa, Jianliang Geng, Fei Fei, Pei Wang, Jiankun Wang, Ying Peng, Ting Geng, Yanjing Li, Wenzhe Huang, Zhenzhong Wang, Wei Xiao, Guangji Wang. Pharmacokinetics and tissue distribution of ginkgolide A, ginkgolide B, and ginkgolide K after intravenous infusion of ginkgo diterpene lactones in a rat model.
Journal of pharmaceutical and biomedical analysis.
2016 Jul; 126(?):109-16. doi:
10.1016/j.jpba.2016.04.035. [PMID: 27182682] - Fugen Wu, Wei Shi, Guojun Zhou, Hongyi Yao, Chengyun Xu, Weiqiang Xiao, Junsong Wu, Ximei Wu. Ginkgolide B functions as a determinant constituent of Ginkgolides in alleviating lipopolysaccharide-induced lung injury.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2016 Jul; 81(?):71-78. doi:
10.1016/j.biopha.2016.03.048. [PMID: 27261579] - Tao Zhou, Wen-ting You, Zeng-chun Ma, Qian-de Liang, Hong-ling Tan, Cheng-rong Xiao, Xiang-lin Tang, Bo-li Zhang, Yu-guang Wang, Yue Gao. Ginkgolide B protects human umbilical vein endothelial cells against xenobiotic injuries via PXR activation.
Acta pharmacologica Sinica.
2016 Feb; 37(2):177-86. doi:
10.1038/aps.2015.124. [PMID: 26775663] - Junqing Gao, Tao Chen, Deqiang Zhao, Jianpu Zheng, Zongjun Liu. Ginkgolide B Exerts Cardioprotective Properties against Doxorubicin-Induced Cardiotoxicity by Regulating Reactive Oxygen Species, Akt and Calcium Signaling Pathways In Vitro and In Vivo.
PloS one.
2016; 11(12):e0168219. doi:
10.1371/journal.pone.0168219. [PMID: 27973574] - Jie Zhao, Ting Geng, Qi Wang, Haihong Si, Xiaoping Sun, Qingming Guo, Yanjing Li, Wenzhe Huang, Gang Ding, Wei Xiao. Pharmacokinetics of Ginkgolide B after Oral Administration of Three Different Ginkgolide B Formulations in Beagle Dogs.
Molecules (Basel, Switzerland).
2015 Nov; 20(11):20031-41. doi:
10.3390/molecules201119678. [PMID: 26561795] - Xiaomei Wu, Jianyou Su, Lei Chen, Baodong Ma, Xiaosu Gu, Li Zhu. Ginkgolide B Protects Neurons from Ischemic Injury by Inhibiting the Expression of RTP801.
Cellular and molecular neurobiology.
2015 Oct; 35(7):943-52. doi:
10.1007/s10571-015-0189-3. [PMID: 25869596] - Yong-Ming Lu, Jian Pan, Wen-Na Zhang, Ai-Ling Hui, Wen-Qiang Guo, Li Huang, Qin-Jun Zhu, Yan Chen. Synthesis, in silico and in vivo blood brain barrier permeability of ginkgolide B cinnamate.
Fitoterapia.
2015 Oct; 106(?):110-4. doi:
10.1016/j.fitote.2015.08.012. [PMID: 26327588] - Xue-Jing Li, Kui Yang, Gang Du, Liang Xu, Ke Lan. Understanding the regioselective hydrolysis of ginkgolide B under physiological environment based on generation, detection, identification, and semi-quantification of the hydrolyzed products.
Analytical and bioanalytical chemistry.
2015 Oct; 407(26):7945-56. doi:
10.1007/s00216-015-8963-0. [PMID: 26302962] - Hai-hong Si, Ting Geng, Xiao-ping Sun, Jie Zhao, Jia Xue. [Absolute bioavailability of ginkgolide compounds in rats].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2015 Jul; 40(14):2882-6. doi:
NULL. [PMID: 26666044] - Xue-Jing Li, Yu-Qing Wang, Jing Yang, Xue Fan, Ling Wang, Kui Yang, Ke Lan. Semi-quantitative determination of monocarboxylate forms of ginkgolide B in plasma by UPLC-MS.
Analytical and bioanalytical chemistry.
2015 May; 407(14):4121-9. doi:
10.1007/s00216-015-8628-z. [PMID: 25822160] - Zhixia Qiu, Lei Wang, Yu Dai, Weichao Ren, Wenwen Jiang, Xijing Chen, Ning Li. The potential drug-drug interactions of ginkgolide B mediated by renal transporters.
Phytotherapy research : PTR.
2015 May; 29(5):662-7. doi:
10.1002/ptr.5294. [PMID: 25589475] - Wenping Wang, Qian Kang, Na Liu, Qing Zhang, Yewen Zhang, Hui Li, Bochen Zhao, Yanyan Chen, Yi Lan, Qiang Ma, Qing Wu. Enhanced dissolution rate and oral bioavailability of Ginkgo biloba extract by preparing solid dispersion via hot-melt extrusion.
Fitoterapia.
2015 Apr; 102(?):189-97. doi:
10.1016/j.fitote.2014.10.004. [PMID: 25446043] - HongXue Ding, ZhiCai Zhang, ShengNan Cao, Yin Xu, JianGuo Yu. Transformation of multi-component ginkgolide into ginkgolide B by Coprinus comatus.
BMC biotechnology.
2015 Mar; 15(?):17. doi:
10.1186/s12896-015-0133-0. [PMID: 25887229] - Hong-Xia Pei, Rong Hua, Cha-Xiang Guan, Xiang Fang. Ginkgolide B Reduces the Degradation of Membrane Phospholipids to Prevent Ischemia/Reperfusion Myocardial Injury in Rats.
Pharmacology.
2015; 96(5-6):233-9. doi:
10.1159/000438945. [PMID: 26382046] - Lei Sun, Zhen He, Jia Ke, Senmao Li, Xianrui Wu, Lei Lian, Xiaowen He, Xiaosheng He, Jiancong Hu, Yifeng Zou, Xiaojian Wu, Ping Lan. PAF receptor antagonist Ginkgolide B inhibits tumourigenesis and angiogenesis in colitis-associated cancer.
International journal of clinical and experimental pathology.
2015; 8(1):432-40. doi:
. [PMID: 25755731] - Xiao-wen Zhou, Zheng Ma, Ting Geng, Zhen-zhong Wang, Gang Ding, Bi Yu-an, Wei Xiao. Evaluation of in vitro inhibition and induction of cytochrome P450 activities by hydrolyzed ginkgolides.
Journal of ethnopharmacology.
2014 Dec; 158 Pt A(?):132-9. doi:
10.1016/j.jep.2014.10.023. [PMID: 25456428] - Ping Huang, Liang Zhang, Chuan Chai, Xiao-Cui Qian, Wen Li, Jun-Song Li, Liu-Qing Di, Bao-Chang Cai. Effects of food and gender on the pharmacokinetics of ginkgolides A, B, C and bilobalide in rats after oral dosing with ginkgo terpene lactones extract.
Journal of pharmaceutical and biomedical analysis.
2014 Nov; 100(?):138-144. doi:
10.1016/j.jpba.2014.07.030. [PMID: 25165009] - G D'Andrea, S Cevoli, D Cologno. Herbal therapy in migraine.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology.
2014 May; 35 Suppl 1(?):135-40. doi:
10.1007/s10072-014-1757-x. [PMID: 24867850] - Pengfei Yang, Xiaolei Cai, Kai Zhou, Chuanhua Lu, Weidong Chen. A novel oil-body nanoemulsion formulation of ginkgolide B: pharmacokinetics study and in vivo pharmacodynamics evaluations.
Journal of pharmaceutical sciences.
2014 Apr; 103(4):1075-84. doi:
10.1002/jps.23866. [PMID: 24496859] - Yuan Yuan, Jian Pan, Zeyu Wu, Ailing Hui, An Zhou. Validated LC-MS-MS method for the determination of prodrug of ginkgolide B in rat plasma and brain: application to pharmacokinetic study.
Journal of chromatographic science.
2013 Mar; 51(3):266-72. doi:
10.1093/chromsci/bms137. [PMID: 22933510] - Dian-Lei Wang, Dai-Yin Peng, Xiu-Hua Tao, Yin Cao, Wei-Dong Chen, Yan Liang, Lin Xie, Xiao-Dong Liu. The pharmacokinetics and conversion of the lactone to the carboxylate forms of ginkgolide B in rat plasma.
Journal of Asian natural products research.
2013; 15(4):337-43. doi:
10.1080/10286020.2013.764866. [PMID: 23421864] - Maria Esposito, Maria Ruberto, Antonio Pascotto, Marco Carotenuto. Nutraceutical preparations in childhood migraine prophylaxis: effects on headache outcomes including disability and behaviour.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology.
2012 Dec; 33(6):1365-8. doi:
10.1007/s10072-012-1019-8. [PMID: 22437495] - Zhen-Yu Wang, Xiao-Fen Mo, Xu-Hua Jiang, Xian-Fang Rong, Hua-Mao Miao. [Ginkgolide B promotes axonal growth of retina ganglion cells by anti-apoptosis in vitro].
Sheng li xue bao : [Acta physiologica Sinica].
2012 Aug; 64(4):417-24. doi:
. [PMID: 22907302] - Jian-Ming Lü, Shaoyu Yan, Saha Jamaluddin, Sarah M Weakley, Zhengdong Liang, Edward B Siwak, Qizhi Yao, Changyi Chen. Ginkgolic acid inhibits HIV protease activity and HIV infection in vitro.
Medical science monitor : international medical journal of experimental and clinical research.
2012 Aug; 18(8):BR293-298. doi:
10.12659/msm.883261. [PMID: 22847190] - Yuna Cui, Dawei Yi, Xiufeng Bai, Baoshan Sun, Yuqing Zhao, Yixuan Zhang. Ginkgolide B produced endophytic fungus (Fusarium oxysporum) isolated from Ginkgo biloba.
Fitoterapia.
2012 Jul; 83(5):913-20. doi:
10.1016/j.fitote.2012.04.009. [PMID: 22537641] - Hong Zhou, Jinsheng Gao, Li Zhou, Xin Li, Weidong Li, Xuejun Li, Yin Xia, Baoxue Yang. Ginkgolide B inhibits renal cyst development in in vitro and in vivo cyst models.
American journal of physiology. Renal physiology.
2012 May; 302(10):F1234-42. doi:
10.1152/ajprenal.00356.2011. [PMID: 22338085] - Xian-tao Zhang, Hao-yan Jiao, Qi-liang Suo. [Study on pharmacokinetics of ginkgolide B injection in Beagle dogs].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2012 May; 35(5):762-5. doi:
". [PMID: 23213741] - Xian-Tao Zhang, Hao-Yan Jiao, Qi-Liang Suo. [Study on the pharmacokinetics of ginkgolide B for injection in rats].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2012 Mar; 35(3):430-3. doi:
NULL. [PMID: 22876684] - Yuko Taki, Kaori Yokotani, Shizuo Yamada, Kazumasa Shinozuka, Yoko Kubota, Yasuo Watanabe, Keizo Umegaki. Ginkgo biloba extract attenuates warfarin-mediated anticoagulation through induction of hepatic cytochrome P450 enzymes by bilobalide in mice.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2012 Jan; 19(2):177-82. doi:
10.1016/j.phymed.2011.06.020. [PMID: 21802929] - Xiyun Liu, Gexin Zhao, Yan Yan, Li Bao, Beidong Chen, Ruomei Qi. Ginkgolide B reduces atherogenesis and vascular inflammation in ApoE(-/-) mice.
PloS one.
2012; 7(5):e36237. doi:
10.1371/journal.pone.0036237. [PMID: 22662117] - Maciej A Pszczolkowski, Kevin Durden, Samantha Sellars, Brian Cowell, John J Brown. Effects of Ginkgo biloba constituents on fruit-infesting behavior of codling moth (Cydia pomonella) in apples.
Journal of agricultural and food chemistry.
2011 Oct; 59(20):10879-86. doi:
10.1021/jf202386c. [PMID: 21905729] - Chun Zhang, Xiujuan Tian, Yi Luo, Xianfang Meng. Ginkgolide B attenuates ethanol-induced neurotoxicity through regulating NADPH oxidases.
Toxicology.
2011 Sep; 287(1-3):124-30. doi:
10.1016/j.tox.2011.06.006. [PMID: 21704112] - Zan Zhang Yang, Jing Li, Shan Xue Li, Wei Feng, Hao Wang. Effect of ginkgolide B on striatal extracellular amino acids in middle cerebral artery occluded rats.
Journal of ethnopharmacology.
2011 Jun; 136(1):117-22. doi:
10.1016/j.jep.2011.04.027. [PMID: 21527331] - Jun Wang, Saihui Zhang, Jing Zhang, Ping Ren, Yingchao Chen, Jihong Li, Wei Wang, Yi Ma, Rongfu Shi, Chunhong Wang, Zhi Yuan. An efficient molecular docking method for adsorbent screening.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Jun; 879(19):1605-9. doi:
10.1016/j.jchromb.2011.03.053. [PMID: 21514905] - Run-Li Ji, Shi-Hai Xia, Yao Di, Wei Xu. Mechanism and dose-effect of Ginkgolide B on severe acute pancreatitis of rats.
World journal of gastroenterology.
2011 May; 17(17):2241-7. doi:
10.3748/wjg.v17.i17.2241. [PMID: 21633536] - Miaomiao Jin, Qingming Guo, Xiaoping Sun, Xuan Zhang, Yaozhong Lv, Wei Xiao. [Pharmacokinetics of ginkgolides sustained-release tablet].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2011 Apr; 36(8):1011-4. doi:
10.4268/cjcmm20110814. [PMID: 21809574] - Andrew J Thompson, Gavin E Jarvis, Rujee K Duke, Graham A R Johnston, Sarah C R Lummis. Ginkgolide B and bilobalide block the pore of the 5-HT₃receptor at a location that overlaps the picrotoxin binding site.
Neuropharmacology.
2011 Feb; 60(2-3):488-95. doi:
10.1016/j.neuropharm.2010.11.003. [PMID: 21059362] - Qian Xiao, Chao Wang, Junchang Li, Qian Hou, Jinghua Li, Jing Ma, Wen Wang, Zongren Wang. Ginkgolide B protects hippocampal neurons from apoptosis induced by beta-amyloid 25-35 partly via up-regulation of brain-derived neurotrophic factor.
European journal of pharmacology.
2010 Nov; 647(1-3):48-54. doi:
10.1016/j.ejphar.2010.08.002. [PMID: 20709055] - Chenfeng Zhang, Minghui Li, Yun Tang, Yanhai Zhang, Min Shi, Longsheng Sheng. [Extraction, isolation and purification for ginkgolide B].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2010 Aug; 35(15):1961-4. doi:
10.4268/cjcmm20101510. [PMID: 20931846] - Susanna Usai, Licia Grazzi, Frank Andrasik, Gennaro Bussone. An innovative approach for migraine prevention in young age: a preliminary study.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology.
2010 Jun; 31 Suppl 1(?):S181-3. doi:
10.1007/s10072-010-0321-6. [PMID: 20464618] - Yong-Gang Liu, Fang-Jun Li, Jing Wang, Xiao-Dong Wang. [Effects of Ginkgolide B on inflammation induced by cerebral ischemia-reperfusion in rats].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2010 Apr; 33(4):578-80. doi:
. [PMID: 20845788] - Karin Woelkart, Elisabeth Feizlmayr, Peter Dittrich, Eckhard Beubler, Fritz Pinl, Andy Suter, Rudolf Bauer. Pharmacokinetics of bilobalide, ginkgolide A and B after administration of three different Ginkgo biloba L. preparations in humans.
Phytotherapy research : PTR.
2010 Mar; 24(3):445-50. doi:
10.1002/ptr.3074. [PMID: 20041430] - Weirong Fang, Yan Deng, Yunman Li, Erxin Shang, Fang Fang, Peng Lv, Li Bai, Yan Qi, Fang Yan, Lishun Mao. Blood brain barrier permeability and therapeutic time window of Ginkgolide B in ischemia-reperfusion injury.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2010 Jan; 39(1-3):8-14. doi:
10.1016/j.ejps.2009.10.002. [PMID: 19833202] - Jing Xu, Changkai Sun, Hui Ma, Lu Wang, Jian Zhang, Yumei Zhang, Lanxiang Wu. [Neuroprotective effect of extract of Ginkgo biloba against excitotoxicty compared with ginkgolide B in neuron cell of rat].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2010 Jan; 35(1):114-7. doi:
. [PMID: 20349729] - Wei Cheng, Chenggen Zhu, Wendong Xu, Xiaona Fan, Yongchun Yang, Yan Li, Xiaoguang Chen, Wenjie Wang, Jiangong Shi. Chemical constituents of the bark of Machilus wangchiana and their biological activities.
Journal of natural products.
2009 Dec; 72(12):2145-52. doi:
10.1021/np900504a. [PMID: 19916529] - Chun Shi, Lina Zhao, Bilian Zhu, Qianxi Li, David T Yew, Zhibin Yao, Jie Xu. Protective effects of Ginkgo biloba extract (EGb761) and its constituents quercetin and ginkgolide B against beta-amyloid peptide-induced toxicity in SH-SY5Y cells.
Chemico-biological interactions.
2009 Sep; 181(1):115-23. doi:
10.1016/j.cbi.2009.05.010. [PMID: 19464278] - Yanling Hao, Yiwei Sun, Chuanying Xu, Xinwei Jiang, Hong Sun, Qin Wu, Changdong Yan, Shuling Gu. Improvement of contractile function in isolated cardiomyocytes from ischemia-reperfusion rats by ginkgolide B pretreatment.
Journal of cardiovascular pharmacology.
2009 Jul; 54(1):3-9. doi:
10.1097/fjc.0b013e3181a91410. [PMID: 19487958] - Rui Li, Beidong Chen, Wei Wu, Li Bao, Jian Li, Ruomei Qi. Ginkgolide B suppresses intercellular adhesion molecule-1 expression via blocking nuclear factor-kappaB activation in human vascular endothelial cells stimulated by oxidized low-density lipoprotein.
Journal of pharmacological sciences.
2009 Jul; 110(3):362-9. doi:
10.1254/jphs.08275fp. [PMID: 19609067] - Lei Wang, Ning Li, De-En Han, Wei Sun, Zi-Dong Gao, Xi-Jing Chen. [Effect of cyclosporine A on the pharmacokinetics of ginkgolide B in rats].
Yao xue xue bao = Acta pharmaceutica Sinica.
2009 Jun; 44(6):632-9. doi:
. [PMID: 19806896] - Chong Chen, Shi-Hai Xia, Hong Chen, Xiao-Hong Li. Therapy for acute pancreatitis with platelet-activating factor receptor antagonists.
World journal of gastroenterology.
2008 Aug; 14(30):4735-8. doi:
10.3748/wjg.14.4735. [PMID: 18720532] - Min Liu, Jian-hai Chen, Fu-rong Dong, Yuan Liu. [Optimized preparation of ginkgolides A and B long-circulating solid lipid nanoparticles by central composite design and response surface method].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2008 May; 28(5):700-3. doi:
". [PMID: 18504183] - Liang Yu, Li-Hong Xiong, Pi-Xin Ran. [The mechanism of inhibition by ginkgolide B on interleukin-8 production induced by 4-hydroxynonenal in bronchial epithelial cells].
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases.
2008 May; 31(5):372-7. doi:
. [PMID: 18953964] - Y Deng, H-C Bi, L-Z Zhao, F He, Y-Q Liu, J-J Yu, Z-M Ou, L Ding, X Chen, Z-Y Huang, M Huang, S-F Zhou. Induction of cytochrome P450s by terpene trilactones and flavonoids of the Ginkgo biloba extract EGb 761 in rats.
Xenobiotica; the fate of foreign compounds in biological systems.
2008 May; 38(5):465-81. doi:
10.1080/00498250701883233. [PMID: 18421621] - Yao Di, Shi-Hai Xia, Chang-Qing Tong. [Effect of ginkgolide B on plasma levels of interleukin-12 and PAF in severe acute pancreatitis in rats].
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.
2008 May; 24(2):152-5. doi:
. [PMID: 21141514] - Agni D Grypioti, Georgia Kostopanagiotou, Constantinos A Demopoulos, Anastasios Roussos, Michael Mykoniatis. Platelet activating factor (PAF) antagonism with ginkgolide B protects the liver against acute injury. importance of controlling the receptor of PAF.
Digestive diseases and sciences.
2008 Apr; 53(4):1054-62. doi:
10.1007/s10620-007-9982-2. [PMID: 17934819] - Jiashu Xie, Cungang Ding, Qinghua Ge, Zhen Zhou, Xiaojin Zhi. Simultaneous determination of ginkgolides A, B, C and bilobalide in plasma by LC-MS/MS and its application to the pharmacokinetic study of Ginkgo biloba extract in rats.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 Mar; 864(1-2):87-94. doi:
10.1016/j.jchromb.2008.01.045. [PMID: 18295555] - Dian-lei Wang, Yan Liang, Wei-dong Chen, Lin Xie, Guang-ji Wang, Xiao-dong Liu. Identification of ginkgolide B metabolites in urine and rat liver cytochrome P450 enzymes responsible for their formation in vitro.
Acta pharmacologica Sinica.
2008 Mar; 29(3):376-84. doi:
10.1111/j.1745-7254.2008.00758.x. [PMID: 18298904] - Ying Deng, Hui-chang Bi, Li-zi Zhao, Xue-ding Wang, Jie Chen, Zhi-min Ou, Liang Ding, Le-jia Xu, Su Guan, Xiao Chen, Shu-Feng Zhou, Min Huang. Induction of cytochrome P450 3A by the Ginkgo biloba extract and bilobalides in human and rat primary hepatocytes.
Drug metabolism letters.
2008 Jan; 2(1):60-6. doi:
10.2174/187231208783478489. [PMID: 19356072] - Jan Krzek, Janusz S Czekaj, Włodzimierz Rzeszutko, Radosław J Ekiert. Validation of capillary gas chromatographic method for determination of bilobalide and ginkgolides A, B, C in Ginkgo biloba dry and liquid extracts.
Acta poloniae pharmaceutica.
2007 Jul; 64(4):303-10. doi:
. [PMID: 18536155]
