Hypotaurine (BioDeep_00000002849)
Secondary id: BioDeep_00000399865
natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019
代谢物信息卡片
化学式: C2H7NO2S (109.0197482)
中文名称: 亚牛磺酸
谱图信息:
最多检出来源 Homo sapiens(blood) 0.35%
Last reviewed on 2024-07-15.
Cite this Page
Hypotaurine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/hypotaurine (retrieved
2024-11-08) (BioDeep RN: BioDeep_00000002849). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: C(CS(=O)O)N
InChI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5)
描述信息
Hypotaurine belongs to the class of organic compounds known as sulfinic acids. Sulfinic acids are compounds containing a sulfinic acid functional group, with the general structure RS(=O)OH (R = organyl, not H). Hypotaurine exists in all living species, ranging from bacteria to humans. Within humans, hypotaurine participates in a number of enzymatic reactions. In particular, hypotaurine can be biosynthesized from cysteamine; which is catalyzed by the enzyme 2-aminoethanethiol dioxygenase. In addition, hypotaurine can be biosynthesized from 3-sulfinoalanine through its interaction with the enzyme cysteine sulfinic acid decarboxylase. In humans, hypotaurine is involved in taurine and hypotaurine metabolism.
[Spectral] Hypotaurine (exact mass = 109.01975) and Cytosine (exact mass = 111.04326) were not completely separated on HPLC under the present analytical conditions as described in AC$XXX. Additionally some of the peaks in this data contains dimers and other unidentified ions.
Hypotaurine is a product of enzyme cysteamine dioxygenase [EC 1.13.11.19] in taurine and hypotaurine metabolism pathway (KEGG). It may function as an antioxidant and a protective agent under physiological conditions (PMID 14992269). [HMDB]
Hypotaurine (2-aminoethanesulfinic acid), an intermediate in taurine biosynthesis from cysteine in astrocytes, is an endogenous inhibitory amino acid of the glycine receptor. Antioxidant[1].
同义名列表
13 个代谢物同义名
2-aminoethane-1-sulfinic acid; 2-Aminoethanesulphinic acid; 2-Amino-ethanesulfinic acid; 2-Aminoethanesulfinic acid; 2-Aminoethylsulfinic acid; 2-Amino-ethanesulfinate; 2-Aminoethanesulphinate; 2-Aminoethanesulfinate; Cystaminesulfinic acid; 2-Aminoethylsulfinate; Cystaminesulfinate; hypotaurine; Hypotaurine
数据库引用编号
39 个数据库交叉引用编号
- ChEBI: CHEBI:16668
- KEGG: C00519
- PubChem: 107812
- HMDB: HMDB0000965
- Metlin: METLIN281
- ChEMBL: CHEMBL1256480
- Wikipedia: Hypotaurine
- MetaCyc: HYPOTAURINE
- foodb: FDB022342
- chemspider: 96959
- CAS: 300-84-5
- MoNA: PR100146
- MoNA: KO000995
- MoNA: KNA00405
- MoNA: KO003087
- MoNA: KNA00404
- MoNA: KNA00016
- MoNA: PR100568
- MoNA: KNA00407
- MoNA: KNA00014
- MoNA: KO003085
- MoNA: KO003086
- MoNA: KO003083
- MoNA: KO000993
- MoNA: KO000996
- MoNA: KO000997
- MoNA: KNA00013
- MoNA: KO000994
- MoNA: PS025103
- MoNA: PS025101
- MoNA: KNA00406
- MoNA: PS025102
- MoNA: KO003084
- PMhub: MS000006660
- 3DMET: B01277
- NIKKAJI: J11.604A
- RefMet: Hypotaurine
- medchemexpress: HY-100803
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-3
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
20 个相关的代谢反应过程信息。
Reactome(12)
- Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
- Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
- Sulfur amino acid metabolism:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia
- Degradation of cysteine and homocysteine:
H2O + HCYS ⟶ 2OBUTA + H2S + ammonia
- Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
- Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
- Sulfur amino acid metabolism:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia
- Degradation of cysteine and homocysteine:
H2O + HCYS ⟶ 2OBUTA + H2S + ammonia
- Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
- Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
- Sulfur amino acid metabolism:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia
- Degradation of cysteine and homocysteine:
H2O + HCYS ⟶ 2OBUTA + H2S + ammonia
BioCyc(0)
WikiPathways(2)
- One-carbon metabolism and related pathways:
5-oxoproline ⟶ Glutamate
- Methionine metabolism leading to sulfur amino acids and related disorders:
Adenosine ⟶ AMP
Plant Reactome(0)
INOH(1)
- Methionine and Cysteine metabolism ( Methionine and Cysteine metabolism ):
H2O + L-Cystathionine ⟶ 2-Oxo-butanoic acid + L-Cysteine + NH3
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(5)
- Taurine and Hypotaurine Metabolism:
L-Cysteine + Oxygen ⟶ 3-Sulfinoalanine
- Taurine and Hypotaurine Biosynthesis:
3-Sulfinoalanine ⟶ Carbon dioxide + Hypotaurine
- Taurine and Hypotaurine Metabolism:
L-Cysteine + Oxygen ⟶ 3-Sulfinoalanine
- Taurine and Hypotaurine Metabolism:
L-Cysteine + Oxygen ⟶ 3-Sulfinoalanine
- Taurine and Hypotaurine Metabolism:
L-Cysteine + Oxygen ⟶ 3-Sulfinoalanine
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Cheng-Lu Yu, Fang Lu, Dong-Hua Yu, Xiao-Min Xu, Peng Xu, Shu-Min Liu. [Mechanism of acteoside in prevention and treatment of gouty arthritis based on liver metabolomics].
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Journal of orthopaedic surgery and research.
2023 Jun; 18(1):409. doi:
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The Science of the total environment.
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Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.
2023 Feb; 22(2):345-356. doi:
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Placenta.
2015 Jun; 36(6):693-8. doi:
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