Hypotaurine (BioDeep_00000002849)

 

Secondary id: BioDeep_00000399865

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


2-aminoethane-1-sulfinic acid

化学式: C2H7NO2S (109.0197)
中文名称: 亚牛磺酸
谱图信息: 最多检出来源 Homo sapiens(blood) 35.37%

Reviewed

Last reviewed on 2024-07-15.

Cite this Page

Hypotaurine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/hypotaurine (retrieved 2024-12-26) (BioDeep RN: BioDeep_00000002849). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(CS(=O)O)N
InChI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5)

描述信息

Hypotaurine belongs to the class of organic compounds known as sulfinic acids. Sulfinic acids are compounds containing a sulfinic acid functional group, with the general structure RS(=O)OH (R = organyl, not H). Hypotaurine exists in all living species, ranging from bacteria to humans. Within humans, hypotaurine participates in a number of enzymatic reactions. In particular, hypotaurine can be biosynthesized from cysteamine; which is catalyzed by the enzyme 2-aminoethanethiol dioxygenase. In addition, hypotaurine can be biosynthesized from 3-sulfinoalanine through its interaction with the enzyme cysteine sulfinic acid decarboxylase. In humans, hypotaurine is involved in taurine and hypotaurine metabolism.
[Spectral] Hypotaurine (exact mass = 109.01975) and Cytosine (exact mass = 111.04326) were not completely separated on HPLC under the present analytical conditions as described in AC$XXX. Additionally some of the peaks in this data contains dimers and other unidentified ions.
Hypotaurine is a product of enzyme cysteamine dioxygenase [EC 1.13.11.19] in taurine and hypotaurine metabolism pathway (KEGG). It may function as an antioxidant and a protective agent under physiological conditions (PMID 14992269). [HMDB]
Hypotaurine (2-aminoethanesulfinic acid), an intermediate in taurine biosynthesis from cysteine in astrocytes, is an endogenous inhibitory amino acid of the glycine receptor. Antioxidant[1].

同义名列表

14 个代谢物同义名

2-aminoethane-1-sulfinic acid; 2-Aminoethanesulphinic acid; 2-Amino-ethanesulfinic acid; 2-Aminoethanesulfinic acid; 2-Aminoethylsulfinic acid; 2-Amino-ethanesulfinate; 2-Aminoethanesulphinate; 2-Aminoethanesulfinate; Cystaminesulfinic acid; 2-Aminoethylsulfinate; Cystaminesulfinate; hypotaurine; Hypotaurine; Hypotaurine



数据库引用编号

42 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

20 个相关的代谢反应过程信息。

Reactome(12)

BioCyc(0)

WikiPathways(2)

Plant Reactome(0)

INOH(1)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(5)

PharmGKB(0)

20 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 AKT1, ALB, CAT, CBS, CSAD, EZR, HPGDS
Peripheral membrane protein 1 EZR
Nucleus 5 AKT1, ALB, BHMT, CBS, GABPA
cytosol 11 ADO, AKT1, ALB, BHMT, CAT, CBS, CDO1, EZR, GPT, GSR, HPGDS
dendrite 1 SLC6A6
centrosome 1 ALB
nucleoplasm 3 AKT1, GABPA, HPGDS
Cell membrane 4 AKT1, GLRA2, SLC6A6, TNF
Cytoplasmic side 1 EZR
lamellipodium 1 AKT1
ruffle membrane 1 EZR
Multi-pass membrane protein 3 GLRA2, RHO, SLC6A6
Synapse 1 GLRA2
cell cortex 2 AKT1, EZR
cell surface 1 TNF
glutamatergic synapse 1 AKT1
Golgi apparatus 2 ALB, RHO
Golgi membrane 2 INS, RHO
neuronal cell body 2 SLC6A6, TNF
postsynapse 1 AKT1
Cytoplasm, cytosol 1 BHMT
endosome 1 EZR
plasma membrane 6 AKT1, EZR, GLRA2, RHO, SLC6A6, TNF
Membrane 6 AKT1, CAT, EZR, GLRA2, RHO, SLC6A6
apical plasma membrane 2 EZR, SLC6A6
basolateral plasma membrane 2 EZR, SLC6A6
brush border 1 EZR
extracellular exosome 6 ALB, BHMT, CAT, EZR, GPT, GSR
endoplasmic reticulum 1 ALB
extracellular space 6 ALB, CXCL8, EZR, IL17A, INS, TNF
perinuclear region of cytoplasm 1 EZR
adherens junction 1 EZR
mitochondrion 3 ADO, CAT, GSR
protein-containing complex 4 AKT1, ALB, CAT, EZR
intracellular membrane-bounded organelle 3 CAT, GLRA2, HPGDS
filopodium 1 EZR
Secreted 4 ALB, CXCL8, IL17A, INS
extracellular region 6 ALB, CAT, CXCL8, IL17A, INS, TNF
mitochondrial matrix 2 CAT, GSR
anchoring junction 1 ALB
ciliary membrane 1 RHO
photoreceptor inner segment 1 RHO
photoreceptor outer segment 1 RHO
external side of plasma membrane 3 GSR, IL17A, TNF
actin cytoskeleton 1 EZR
microtubule cytoskeleton 1 AKT1
apical part of cell 1 EZR
cell-cell junction 2 AKT1, RHO
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 2 AKT1, EZR
postsynaptic membrane 1 SLC6A6
Apical cell membrane 1 EZR
Cell projection, ruffle membrane 1 EZR
Membrane raft 1 TNF
Cytoplasm, cytoskeleton 1 EZR
focal adhesion 2 CAT, EZR
spindle 1 AKT1
GABA-ergic synapse 2 GLRA2, SLC6A6
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
Postsynaptic cell membrane 1 GLRA2
ruffle 1 EZR
neuron projection 1 GLRA2
ciliary basal body 3 AKT1, ALB, EZR
chromatin 1 GABPA
cell projection 3 EZR, GLRA2, SLC6A6
phagocytic cup 1 TNF
cell periphery 1 EZR
cytoskeleton 1 EZR
centriole 1 ALB
Cell projection, cilium, photoreceptor outer segment 1 RHO
plasma membrane protein complex 1 SLC6A6
spindle pole 1 ALB
Cytoplasm, cell cortex 1 EZR
actin filament 1 EZR
blood microparticle 1 ALB
sperm midpiece 1 RHO
transmembrane transporter complex 1 GLRA2
Cell projection, microvillus membrane 1 EZR
microvillus membrane 2 EZR, SLC6A6
fibrillar center 1 EZR
endosome lumen 1 INS
microvillus 1 EZR
chloride channel complex 1 GLRA2
Cell projection, microvillus 1 EZR
Golgi-associated vesicle membrane 1 RHO
plasma membrane raft 1 EZR
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 ALB, INS
platelet alpha granule lumen 1 ALB
Photoreceptor inner segment membrane 1 RHO
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 EZR
uropod 1 EZR
postsynaptic specialization membrane 1 GLRA2
photoreceptor outer segment membrane 1 RHO
sperm head plasma membrane 1 RHO
photoreceptor disc membrane 1 RHO
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
cortical cytoskeleton 1 EZR
catalase complex 1 CAT
glycinergic synapse 1 GLRA2
rod photoreceptor outer segment 1 RHO
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Cheng-Lu Yu, Fang Lu, Dong-Hua Yu, Xiao-Min Xu, Peng Xu, Shu-Min Liu. [Mechanism of acteoside in prevention and treatment of gouty arthritis based on liver metabolomics]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2024 Jan; 49(1):224-231. doi: 10.19540/j.cnki.cjcmm.20230808.402. [PMID: 38403355]
  • Mengxing Yin, Dezhi Zhou, Fu Jia, Xiaosan Su, Xiufang Li, Ruifen Sun, Junmin Li. Metabolomics analysis of the potential mechanism of Yi-Guan-Jian decoction to reverse bone loss in glucocorticoid-induced osteoporosis. Journal of orthopaedic surgery and research. 2023 Jun; 18(1):409. doi: 10.1186/s13018-023-03778-6. [PMID: 37277810]
  • João A Rodrigues, Mónica Silva, Rita Araújo, Leonor Madureira, Amadeu M V M Soares, Rosa Freitas, Ana M Gil. The influence of temperature rise on the metabolic response of Ruditapes philippinarum clams to 17-α-ethinylestradiol. The Science of the total environment. 2023 Mar; 877(?):162898. doi: 10.1016/j.scitotenv.2023.162898. [PMID: 36934939]
  • Katsuhiko Tsuchida, Natsuki Sakiyama. Blue light-induced lipid oxidation and the antioxidant property of hypotaurine: evaluation via measuring ultraweak photon emission. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 2023 Feb; 22(2):345-356. doi: 10.1007/s43630-022-00319-8. [PMID: 36271182]
  • Yangyang Wang, Yanping Sun, Bingyou Yang, Qiuhong Wang, Haixue Kuang. Integrate metabolomics strategy and target prediction to reveal the ameliorate effect of four typical 'cold' property herbs on hyperthyroidism rats. Journal of ethnopharmacology. 2023 Jan; 301(?):115772. doi: 10.1016/j.jep.2022.115772. [PMID: 36202164]
  • Hong Chang, Hong-Yu Meng, Wan-Fu Bai, Qing-Gang Meng. A metabolomic approach to elucidate the inhibitory effects of baicalin in pulmonary fibrosis. Pharmaceutical biology. 2021 Dec; 59(1):1016-1025. doi: 10.1080/13880209.2021.1950192. [PMID: 34362286]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Sunil Veeravalli, Ian R Phillips, Rafael T Freire, Dorsa Varshavi, Jeremy R Everett, Elizabeth A Shephard. Flavin-Containing Monooxygenase 1 Catalyzes the Production of Taurine from Hypotaurine. Drug metabolism and disposition: the biological fate of chemicals. 2020 05; 48(5):378-385. doi: 10.1124/dmd.119.089995. [PMID: 32156684]
  • Yan Xu, Tianyu Zhao, Haowei Ren, Yindan Xie, Jingjing An, Jiaqi Shang, Dina Tabys, Ning Liu. Urinary Metabolic Profiling via LC-MS/MS Reveals Impact of Bovine Lactoferrin on Bone Formation in Growing SD Rats. Nutrients. 2020 Apr; 12(4):. doi: 10.3390/nu12041116. [PMID: 32316396]
  • Mohammad Seify, Mahsa Zarabadipour, Leila Rashki Ghaleno, AliReza Alizadeh, Mojtaba Rezazadeh Valojerdi. The anti-oxidant roles of Taurine and Hypotaurine on acrosome integrity, HBA and HSPA2 of the human sperm during vitrification and post warming in two different temperature. Cryobiology. 2019 10; 90(?):89-95. doi: 10.1016/j.cryobiol.2019.07.004. [PMID: 31330124]
  • Jing Zhou, Nan Yao, Shuxia Wang, Dongchen An, Kangna Cao, Jiali Wei, Ning Li, Di Zhao, Lirui Wang, Xijing Chen, Yang Lu. Fructus Gardeniae-induced gastrointestinal injury was associated with the inflammatory response mediated by the disturbance of vitamin B6, phenylalanine, arachidonic acid, taurine and hypotaurine metabolism. Journal of ethnopharmacology. 2019 May; 235(?):47-55. doi: 10.1016/j.jep.2019.01.041. [PMID: 30735766]
  • Carlos Terriente-Palacios, Isabel Diaz, Massimo Castellari. A validated ultra-performance liquid chromatography with diode array detection coupled to electrospray ionization and triple quadrupole mass spectrometry method to simultaneously quantify taurine, homotaurine, hypotaurine and amino acids in macro- and microalgae. Journal of chromatography. A. 2019 Mar; 1589(?):83-92. doi: 10.1016/j.chroma.2018.12.058. [PMID: 30600163]
  • Atsushi Asano, Heather B Roman, Lawrence L Hirschberger, Ai Ushiyama, Jacquelyn L Nelson, Meleana M Hinchman, Martha H Stipanuk, Alexander J Travis. Cysteine dioxygenase is essential for mouse sperm osmoadaptation and male fertility. The FEBS journal. 2018 05; 285(10):1827-1839. doi: 10.1111/febs.14449. [PMID: 29604178]
  • Shozo Tomonaga, Hirofumi Okuyama, Tetsuya Tachibana, Ryosuke Makino. Effects of high ambient temperature on plasma metabolomic profiles in chicks. Animal science journal = Nihon chikusan Gakkaiho. 2018 Feb; 89(2):448-455. doi: 10.1111/asj.12951. [PMID: 29154397]
  • Tomohiro Nishimura, Kei Higuchi, Yuko Yoshida, Yuki Sugita-Fujisawa, Kazuaki Kojima, Maiko Sugimoto, Marie Santo, Masatoshi Tomi, Emi Nakashima. Hypotaurine Is a Substrate of GABA Transporter Family Members GAT2/Slc6a13 and TAUT/Slc6a6. Biological & pharmaceutical bulletin. 2018; 41(10):1523-1529. doi: 10.1248/bpb.b18-00168. [PMID: 30270321]
  • Hongming Guo, Heng Zhou, Jing Zhang, Wenxue Guan, Sheng Xu, Wenbiao Shen, Guohua Xu, Yanjie Xie, Christine Helen Foyer. l-cysteine desulfhydrase-related H2 S production is involved in OsSE5-promoted ammonium tolerance in roots of Oryza sativa. Plant, cell & environment. 2017 Sep; 40(9):1777-1790. doi: 10.1111/pce.12982. [PMID: 28474399]
  • Chieh-Lun Liu, Aaron M Watson, Allen R Place, Rosemary Jagus. Taurine Biosynthesis in a Fish Liver Cell Line (ZFL) Adapted to a Serum-Free Medium. Marine drugs. 2017 May; 15(6):. doi: 10.3390/md15060147. [PMID: 28587087]
  • Sa Rang Lim, Sun-Hee Hyun, Seul Gi Lee, Jin-Young Kim, So-Hyun Kim, Sang-Jin Park, Kyoung-Sik Moon, Donggeun Sul, Dong Hyun Kim, Hyung-Kyoon Choi. Potential urinary biomarkers of nephrotoxicity in cyclophosphamide-treated rats investigated by NMR-based metabolic profiling. Journal of biochemical and molecular toxicology. 2017 Mar; 31(3):. doi: 10.1002/jbt.21871. [PMID: 27870266]
  • Agnieszka Partyka, Olga Rodak, Joanna Bajzert, Joanna Kochan, Wojciech Niżański. The Effect of L-Carnitine, Hypotaurine, and Taurine Supplementation on the Quality of Cryopreserved Chicken Semen. BioMed research international. 2017; 2017(?):7279341. doi: 10.1155/2017/7279341. [PMID: 28523277]
  • R Boni, A Gallo, S Cecchini. Kinetic activity, membrane mitochondrial potential, lipid peroxidation, intracellular pH and calcium of frozen/thawed bovine spermatozoa treated with metabolic enhancers. Andrology. 2017 01; 5(1):133-145. doi: 10.1111/andr.12259. [PMID: 27769103]
  • Xie-Feng Ye, Yanfeng Xue, Tianxiao Ling, Yong Wang, Xiao-Na Yu, Changxin Cheng, Guosheng Feng, Liangbin Hu, Zhiqi Shi, Jian Chen. Cinnamaldehyde Ameliorates Cadmium-Inhibited Root Elongation in Tobacco Seedlings via Decreasing Endogenous Hydrogen Sulfide Production. Molecules (Basel, Switzerland). 2016 Dec; 22(1):. doi: 10.3390/molecules22010015. [PMID: 28029133]
  • Renyi Peng, Zhiyuan Bian, Lina Zhou, Wei Cheng, Na Hai, Changquan Yang, Tao Yang, Xinyu Wang, Chongying Wang. Hydrogen sulfide enhances nitric oxide-induced tolerance of hypoxia in maize (Zea mays L.). Plant cell reports. 2016 Nov; 35(11):2325-2340. doi: 10.1007/s00299-016-2037-4. [PMID: 27516180]
  • Seung-Jung Ha, Byung-Gak Kim, Yong-An Lee, Yong-Hee Kim, Bang-Jin Kim, Sang-Eun Jung, Myeong-Geol Pang, Buom-Yong Ryu. Effect of Antioxidants and Apoptosis Inhibitors on Cryopreservation of Murine Germ Cells Enriched for Spermatogonial Stem Cells. PloS one. 2016; 11(8):e0161372. doi: 10.1371/journal.pone.0161372. [PMID: 27548381]
  • Mohammad Golam Mostofa, Anisur Rahman, Md Mesbah Uddin Ansary, Ayaka Watanabe, Masayuki Fujita, Lam-Son Phan Tran. Hydrogen sulfide modulates cadmium-induced physiological and biochemical responses to alleviate cadmium toxicity in rice. Scientific reports. 2015 Sep; 5(?):14078. doi: 10.1038/srep14078. [PMID: 26361343]
  • Jessica R Terrill, Miranda D Grounds, Peter G Arthur. Taurine deficiency, synthesis and transport in the mdx mouse model for Duchenne Muscular Dystrophy. The international journal of biochemistry & cell biology. 2015 Sep; 66(?):141-8. doi: 10.1016/j.biocel.2015.07.016. [PMID: 26239309]
  • Hui Chan Kwak, Young-Mi Kim, Soo Jin Oh, Sang Kyum Kim. Sulfur amino acid metabolism in Zucker diabetic fatty rats. Biochemical pharmacology. 2015 Aug; 96(3):256-66. doi: 10.1016/j.bcp.2015.05.014. [PMID: 26047850]
  • T Nishimura, M Duereh, Y Sugita, Y Yoshida, K Higuchi, M Tomi, E Nakashima. Protective effect of hypotaurine against oxidative stress-induced cytotoxicity in rat placental trophoblasts. Placenta. 2015 Jun; 36(6):693-8. doi: 10.1016/j.placenta.2015.02.014. [PMID: 25801460]
  • Tao Fang, Zeyu Cao, Jiale Li, Wenbiao Shen, Liqin Huang. Auxin-induced hydrogen sulfide generation is involved in lateral root formation in tomato. Plant physiology and biochemistry : PPB. 2014 Mar; 76(?):44-51. doi: 10.1016/j.plaphy.2013.12.024. [PMID: 24463534]
  • Tomohiro Nishimura, Kei Higuchi, Yoshimichi Sai, Yuki Sugita, Yuko Yoshida, Masatoshi Tomi, Masami Wada, Tomohiko Wakayama, Atsushi Tamura, Sachiko Tsukita, Tomoyoshi Soga, Emi Nakashima. Fetal growth retardation and lack of hypotaurine in ezrin knockout mice. PloS one. 2014; 9(8):e105423. doi: 10.1371/journal.pone.0105423. [PMID: 25144766]
  • F S Gonçalves, L S S Barretto, R P Arruda, S H V Perri, G Z Mingoti. Heparin and penicillamine-hypotaurine-epinephrine (PHE) solution during bovine in vitro fertilization procedures impair the quality of spermatozoa but improve normal oocyte fecundation and early embryonic development. In vitro cellular & developmental biology. Animal. 2014 Jan; 50(1):39-47. doi: 10.1007/s11626-013-9675-4. [PMID: 23949783]
  • Heather B Roman, Lawrence L Hirschberger, Jakub Krijt, Alessandro Valli, Viktor Kožich, Martha H Stipanuk. The cysteine dioxgenase knockout mouse: altered cysteine metabolism in nonhepatic tissues leads to excess H2S/HS(-) production and evidence of pancreatic and lung toxicity. Antioxidants & redox signaling. 2013 Oct; 19(12):1321-36. doi: 10.1089/ars.2012.5010. [PMID: 23350603]
  • Young Suk Jung, Kang Uk Yun, Chang Seon Ryu, Jung Min Oh, Hui Chan Kwak, Ji-Yoon Lee, Song-Kyu Park, Bong Hee Kim, Soo Jin Oh, Sang Kyum Kim. Alterations in hepatic metabolism of sulfur amino acids in non-obese type-2 diabetic Goto-Kakizaki rats. Chemico-biological interactions. 2013 Jul; 204(2):80-7. doi: 10.1016/j.cbi.2013.04.014. [PMID: 23665415]
  • S Martínez-Páramo, P Diogo, M T Dinis, F Soares, C Sarasquete, E Cabrita. Effect of two sulfur-containing amino acids, taurine and hypotaurine in European sea bass (Dicentrarchus labrax) sperm cryopreservation. Cryobiology. 2013 Jun; 66(3):333-8. doi: 10.1016/j.cryobiol.2013.04.001. [PMID: 23583301]
  • Kang Uk Yun, Chang Seon Ryu, Ji-Yoon Lee, Jung-Ran Noh, Chul-Ho Lee, Hyun-Sun Lee, Jong Soon Kang, Song Kyu Park, Bong-Hee Kim, Sang Kyum Kim. Hepatic metabolism of sulfur amino acids in db/db mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2013 Mar; 53(?):180-6. doi: 10.1016/j.fct.2012.11.046. [PMID: 23220616]
  • Abdel Ali Belaidi, Guenter Schwarz. Molybdenum cofactor deficiency: metabolic link between taurine and S-sulfocysteine. Advances in experimental medicine and biology. 2013; 776(?):13-9. doi: 10.1007/978-1-4614-6093-0_2. [PMID: 23392866]
  • Young S Jung, Sun J Kim, Do Y Kwon, Young C Kim. Metabolomic analysis of sulfur-containing substances and polyamines in regenerating rat liver. Amino acids. 2012 Jun; 42(6):2095-102. doi: 10.1007/s00726-011-0946-7. [PMID: 21626405]
  • Iori Ueki, Heather B Roman, Lawrence L Hirschberger, Carolyn Junior, Martha H Stipanuk. Extrahepatic tissues compensate for loss of hepatic taurine synthesis in mice with liver-specific knockout of cysteine dioxygenase. American journal of physiology. Endocrinology and metabolism. 2012 May; 302(10):E1292-9. doi: 10.1152/ajpendo.00589.2011. [PMID: 22414809]
  • Hui Dong, Aihua Zhang, Hui Sun, Huiyu Wang, Xin Lu, Mo Wang, Bei Ni, Xijun Wang. Ingenuity pathways analysis of urine metabolomics phenotypes toxicity of Chuanwu in Wistar rats by UPLC-Q-TOF-HDMS coupled with pattern recognition methods. Molecular bioSystems. 2012 Apr; 8(4):1206-21. doi: 10.1039/c1mb05366c. [PMID: 22282765]
  • P Guérin, E Rosset, M Rey, G Febvay, P Bruyère, N Corrao, V Neto, S Buff. Amino acids in cat fallopian tube and follicular fluids. Theriogenology. 2012 Feb; 77(3):558-62. doi: 10.1016/j.theriogenology.2011.08.031. [PMID: 21982431]
  • Yani Wu, Yinan Zhang, Guoxiang Xie, Aihua Zhao, Xiaolan Pan, Tianlu Chen, Yixue Hu, Yumin Liu, Yu Cheng, Yi Chi, Lei Yao, Wei Jia. The metabolic responses to aerial diffusion of essential oils. PloS one. 2012; 7(9):e44830. doi: 10.1371/journal.pone.0044830. [PMID: 22984571]
  • Massimo Bionaz, Kathiravan Periasamy, Sandra L Rodriguez-Zas, Robin E Everts, Harris A Lewin, Walter L Hurley, Juan J Loor. Old and new stories: revelations from functional analysis of the bovine mammary transcriptome during the lactation cycle. PloS one. 2012; 7(3):e33268. doi: 10.1371/journal.pone.0033268. [PMID: 22428004]
  • Eiji Shigetomi, Xiaoping Tong, Kelvin Y Kwan, David P Corey, Baljit S Khakh. TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3. Nature neuroscience. 2011 Dec; 15(1):70-80. doi: 10.1038/nn.3000. [PMID: 22158513]
  • Hangxing Ren, Li Li, Hongwei Su, Lingyang Xu, Caihong Wei, Li Zhang, Hongbin Li, Wenzhong Liu, Lixin Du. Histological and transcriptome-wide level characteristics of fetal myofiber hyperplasia during the second half of gestation in Texel and Ujumqin sheep. BMC genomics. 2011 Aug; 12(?):411. doi: 10.1186/1471-2164-12-411. [PMID: 21838923]
  • Masayo Aoki, Yutaka Konya, Takeshi Takagaki, Koji Umemura, Yoshihisa Sogame, Takashi Katsumata, Setsuko Komuro. Metabolomic investigation of cholestasis in a rat model using ultra-performance liquid chromatography/tandem mass spectrometry. Rapid communications in mass spectrometry : RCM. 2011 Jul; 25(13):1847-52. doi: 10.1002/rcm.5072. [PMID: 21638360]
  • E Cabrita, S Ma, P Diogo, S Martínez-Páramo, C Sarasquete, M T Dinis. The influence of certain aminoacids and vitamins on post-thaw fish sperm motility, viability and DNA fragmentation. Animal reproduction science. 2011 May; 125(1-4):189-95. doi: 10.1016/j.anireprosci.2011.03.003. [PMID: 21482049]
  • Ismail Aytekin, Serap Unubol Aypak. Levels of selected minerals, nitric oxide, and vitamins in aborted Sakis sheep raised under semitropical conditions. Tropical animal health and production. 2011 Feb; 43(2):511-4. doi: 10.1007/s11250-010-9724-x. [PMID: 21076941]
  • R Francik, M Krośniak, M Barlik, A Kudła, R Gryboś, T Librowski. Impact of vanadium complexes treatment on the oxidative stress factors in wistar rats plasma. Bioinorganic chemistry and applications. 2011; 2011(?):206316. doi: 10.1155/2011/206316. [PMID: 22007153]
  • Liming Xue, Yin Wang, Lei Liu, Lu Zhao, Ting Han, Qiaoyan Zhang, Luping Qin. A HNMR-based metabonomics study of postmenopausal osteoporosis and intervention effects of Er-Xian Decoction in ovariectomized rats. International journal of molecular sciences. 2011; 12(11):7635-51. doi: 10.3390/ijms12117635. [PMID: 22174622]
  • Angela M Boutté, W Hayes McDonald, Yu Shyr, Li Yang, P Charles Lin. Characterization of the MDSC proteome associated with metastatic murine mammary tumors using label-free mass spectrometry and shotgun proteomics. PloS one. 2011; 6(8):e22446. doi: 10.1371/journal.pone.0022446. [PMID: 21853032]
  • Amrit Kaur Bansal, G S Bilaspuri. Impacts of oxidative stress and antioxidants on semen functions. Veterinary medicine international. 2010 Sep; 2010(?):. doi: 10.4061/2011/686137. [PMID: 20871827]
  • Mélanie Bousquet, Claire Gibrat, Mélissa Ouellet, Claude Rouillard, Frédéric Calon, Francesca Cicchetti. Cystamine metabolism and brain transport properties: clinical implications for neurodegenerative diseases. Journal of neurochemistry. 2010 Sep; 114(6):1651-8. doi: 10.1111/j.1471-4159.2010.06874.x. [PMID: 20569301]
  • Miteshkumar Acharya, Cesar A Lau-Cam. Comparison of the protective actions of N-acetylcysteine, hypotaurine and taurine against acetaminophen-induced hepatotoxicity in the rat. Journal of biomedical science. 2010 Aug; 17 Suppl 1(?):S35. doi: 10.1186/1423-0127-17-s1-s35. [PMID: 20804611]
  • Fili Fazzino, Francisco Obregón, Lucimey Lima. Taurine and proliferation of lymphocytes in physically restrained rats. Journal of biomedical science. 2010 Aug; 17 Suppl 1(?):S24. doi: 10.1186/1423-0127-17-s1-s24. [PMID: 20804599]
  • Kashyap G Pandya, Maulik R Patel, Cesar A Lau-Cam. Comparative study of the binding characteristics to and inhibitory potencies towards PARP and in vivo antidiabetogenic potencies of taurine, 3-aminobenzamide and nicotinamide. Journal of biomedical science. 2010 Aug; 17 Suppl 1(?):S16. doi: 10.1186/1423-0127-17-s1-s16. [PMID: 20804590]
  • Andrey G Taranukhin, Elena Y Taranukhina, Pirjo Saransaari, Irina M Podkletnova, Markku Pelto-Huikko, Simo S Oja. Neuroprotection by taurine in ethanol-induced apoptosis in the developing cerebellum. Journal of biomedical science. 2010 Aug; 17 Suppl 1(?):S12. doi: 10.1186/1423-0127-17-s1-s12. [PMID: 20804586]
  • Russell W Chesney, Xiaobin Han, Andrea B Patters. Taurine and the renal system. Journal of biomedical science. 2010 Aug; 17 Suppl 1(?):S4. doi: 10.1186/1423-0127-17-s1-s4. [PMID: 20804616]
  • Tapan M Bhavsar, Sanket N Patel, Cesar A Lau-Cam. Protective action of taurine, given as a pretreatment or as a posttreatment, against endotoxin-induced acute lung inflammation in hamsters. Journal of biomedical science. 2010 Aug; 17 Suppl 1(?):S19. doi: 10.1186/1423-0127-17-s1-s19. [PMID: 20804593]
  • Tadayuki Sakuragawa, Takako Hishiki, Yuki Ueno, Satsuki Ikeda, Tomoyoshi Soga, Ayako Yachie-Kinoshita, Mayumi Kajimura, Makoto Suematsu. Hypotaurine is an Energy-Saving Hepatoprotective Compound against Ischemia-Reperfusion Injury of the Rat Liver. Journal of clinical biochemistry and nutrition. 2010 Mar; 46(2):126-34. doi: 10.3164/jcbn.09-91. [PMID: 20216945]
  • L C Kusinski, C J P Jones, P N Baker, C P Sibley, J D Glazier. Isolation of plasma membrane vesicles from mouse placenta at term and measurement of system A and system beta amino acid transporter activity. Placenta. 2010 Jan; 31(1):53-9. doi: 10.1016/j.placenta.2009.11.006. [PMID: 19954844]
  • Mohammadreza Ghandforoush-Sattari, Siminozar Mashayekhi, Channarayapatna V Krishna, John P Thompson, Philipp A Routledge. Pharmacokinetics of oral taurine in healthy volunteers. Journal of amino acids. 2010; 2010(?):346237. doi: 10.4061/2010/346237. [PMID: 22331997]
  • Mary E Bollard, Nancy R Contel, Timothy M D Ebbels, Leon Smith, Olaf Beckonert, Glenn H Cantor, Lois Lehman-McKeeman, Elaine C Holmes, John C Lindon, Jeremy K Nicholson, Hector C Keun. NMR-based metabolic profiling identifies biomarkers of liver regeneration following partial hepatectomy in the rat. Journal of proteome research. 2010 Jan; 9(1):59-69. doi: 10.1021/pr900200v. [PMID: 19445528]
  • Mustafa Numan Bucak, Pürhan Barbaros Tuncer, Serpil Sariözkan, Pinar Alkim Ulutaş, Kenan Coyan, Nuri Başpinar, Birol Ozkalp. Effects of hypotaurine, cysteamine and aminoacids solution on post-thaw microscopic and oxidative stress parameters of Angora goat semen. Research in veterinary science. 2009 Dec; 87(3):468-72. doi: 10.1016/j.rvsc.2009.04.014. [PMID: 19457525]
  • Abasalt H Colagar, Eisa T Marzony. Ascorbic Acid in human seminal plasma: determination and its relationship to sperm quality. Journal of clinical biochemistry and nutrition. 2009 Sep; 45(2):144-9. doi: 10.3164/jcbn.08-251. [PMID: 19794921]
  • Jennifer Mier-Cabrera, Tania Aburto-Soto, Soraya Burrola-Méndez, Luis Jiménez-Zamudio, Mari C Tolentino, Esther Casanueva, César Hernández-Guerrero. Women with endometriosis improved their peripheral antioxidant markers after the application of a high antioxidant diet. Reproductive biology and endocrinology : RB&E. 2009 May; 7(?):54. doi: 10.1186/1477-7827-7-54. [PMID: 19476631]
  • Seongwon Seo, Harris A Lewin. Reconstruction of metabolic pathways for the cattle genome. BMC systems biology. 2009 Mar; 3(?):33. doi: 10.1186/1752-0509-3-33. [PMID: 19284618]
  • Hui-Ting Yang, Yi-Wen Chien, Jen-Horng Tsen, Ching-Chien Chang, Jer-Hwa Chang, Shih-Yi Huang. Taurine supplementation improves the utilization of sulfur-containing amino acids in rats continually administrated alcohol. The Journal of nutritional biochemistry. 2009 Feb; 20(2):132-9. doi: 10.1016/j.jnutbio.2008.01.009. [PMID: 18547794]
  • A Martins-Bessa, A Rocha, A Mayenco-Aguirre. Effects of taurine and hypotaurine supplementation and ionophore concentrations on post-thaw acrosome reaction of dog spermatozoa. Theriogenology. 2009 Jan; 71(2):248-53. doi: 10.1016/j.theriogenology.2008.07.006. [PMID: 18774600]
  • Davekanand Gossai, Cesar A Lau-Cam. The effects of taurine, taurine homologs and hypotaurine on cell and membrane antioxidative system alterations caused by type 2 diabetes in rat erythrocytes. Advances in experimental medicine and biology. 2009; 643(?):359-68. doi: 10.1007/978-0-387-75681-3_37. [PMID: 19239167]
  • J A Ortega, J M Ortega, D Julian. Hypotaurine and sulfhydryl-containing antioxidants reduce H2S toxicity in erythrocytes from a marine invertebrate. The Journal of experimental biology. 2008 Dec; 211(Pt 24):3816-25. doi: 10.1242/jeb.021303. [PMID: 19043054]
  • Sun J Kim, Young S Jung, Do Y Kwon, Young C Kim. Alleviation of acute ethanol-induced liver injury and impaired metabolomics of S-containing substances by betaine supplementation. Biochemical and biophysical research communications. 2008 Apr; 368(4):893-8. doi: 10.1016/j.bbrc.2008.02.003. [PMID: 18267108]
  • Sandrine P Claus, Tsz M Tsang, Yulan Wang, Olivier Cloarec, Eleni Skordi, François-Pierre Martin, Serge Rezzi, Alastair Ross, Sunil Kochhar, Elaine Holmes, Jeremy K Nicholson. Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes. Molecular systems biology. 2008; 4(?):219. doi: 10.1038/msb.2008.56. [PMID: 18854818]
  • In Sun Park, Young Hee Kang, Jung Sook Kang. Effects of taurine on plasma and liver lipids, erythrocyte ouabain sensitive Na efflux and platelet aggregation in Sprague Dawley rats. Nutrition research and practice. 2007; 1(3):200-5. doi: 10.4162/nrp.2007.1.3.200. [PMID: 20368939]
  • H Nakamura, J Yatsuki, T Ubuka. Production of hypotaurine, taurine and sulfate in rats and mice injected with L-cysteinesulfinate. Amino acids. 2006 Jul; 31(1):27-33. doi: 10.1007/s00726-005-0277-7. [PMID: 16680400]
  • Hui-Ting Yang, Yue-Hwa Chen, Wan-Chun Chiu, Shih-Yi Huang. Effects of consecutive high-dose alcohol administration on the utilization of sulfur-containing amino acids by rats. The Journal of nutritional biochemistry. 2006 Jan; 17(1):45-50. doi: 10.1016/j.jnutbio.2005.05.002. [PMID: 16084077]
  • Chie Suzuki, Koji Yoshioka. Effects of amino acid supplements and replacement of polyvinyl alcohol with bovine serum albumin in porcine zygote medium. Reproduction, fertility, and development. 2006; 18(7):789-95. doi: 10.1071/rd06032. [PMID: 17032588]
  • Samuel Buff, Véronique Lambert, Thierry Marchal, Pierre Guérin. Isolation, culture and characteristics of epididymal epithelial cells from adult cats. Theriogenology. 2005 Oct; 64(7):1603-18. doi: 10.1016/j.theriogenology.2005.04.020. [PMID: 15907991]
  • John T Pinto, Jeremy M Van Raamsdonk, Blair R Leavitt, Michael R Hayden, Thomas M Jeitner, Howard T Thaler, Boris F Krasnikov, Arthur J L Cooper. Treatment of YAC128 mice and their wild-type littermates with cystamine does not lead to its accumulation in plasma or brain: implications for the treatment of Huntington disease. Journal of neurochemistry. 2005 Aug; 94(4):1087-101. doi: 10.1111/j.1471-4159.2005.03255.x. [PMID: 15992377]
  • Paul H Yancey. Organic osmolytes as compatible, metabolic and counteracting cytoprotectants in high osmolarity and other stresses. The Journal of experimental biology. 2005 Aug; 208(Pt 15):2819-30. doi: 10.1242/jeb.01730. [PMID: 16043587]
  • H Funahashi, T Sano. Select antioxidants improve the function of extended boar semen stored at 10 degrees C. Theriogenology. 2005 Apr; 63(6):1605-16. doi: 10.1016/j.theriogenology.2004.06.016. [PMID: 15763105]
  • Audrey M Pruski, Aline Fiala-Médioni. Stimulatory effect of sulphide on thiotaurine synthesis in three hydrothermal-vent species from the East Pacific Rise. The Journal of experimental biology. 2003 Sep; 206(Pt 17):2923-30. doi: 10.1242/jeb.00513. [PMID: 12878661]
  • Young S Jung, Hye E Kwak, Kwon H Choi, Young C Kim. Effect of acute ethanol administration on S-amino acid metabolism: increased utilization of cysteine for synthesis of taurine rather than glutathione. Advances in experimental medicine and biology. 2003; 526(?):245-52. doi: 10.1007/978-1-4615-0077-3_31. [PMID: 12908607]
  • S K Kim, J M Seo, Y S Jung, H E Kwak, Y C Kim. Alterations in hepatic metabolism of sulfur-containing amino acids induced by ethanol in rats. Amino acids. 2003; 24(1-2):103-10. doi: 10.1007/s00726-002-0324-6. [PMID: 12624741]
  • James P McCarter, Makedonka Dautova Mitreva, John Martin, Mike Dante, Todd Wylie, Uma Rao, Deana Pape, Yvette Bowers, Brenda Theising, Claire V Murphy, Andrew P Kloek, Brandi J Chiapelli, Sandra W Clifton, David Mck Bird, Robert H Waterston. Analysis and functional classification of transcripts from the nematode Meloidogyne incognita. Genome biology. 2003; 4(4):R26. doi: 10.1186/gb-2003-4-4-r26. [PMID: 12702207]
  • U K Hahn, R C Bender, C J Bayne. Killing of Schistosoma mansoni sporocysts by hemocytes from resistant Biomphalaria glabrata: role of reactive oxygen species. The Journal of parasitology. 2001 Apr; 87(2):292-9. doi: 10.1645/0022-3395(2001)087[0292:kosmsb]2.0.co;2. [PMID: 11318558]
  • S Buff, A Donzé, P Guérin, J Guillaud, A Fontbonne, Y Ménézo. Taurine and hypotaurine in spermatozoa and epididymal fluid of cats. Journal of reproduction and fertility. Supplement. 2001; 57(?):93-5. doi: NULL. [PMID: 11787195]
  • F W van Overveld, G R Haenen, J Rhemrev, J P Vermeiden, A Bast. Tyrosine as important contributor to the antioxidant capacity of seminal plasma. Chemico-biological interactions. 2000 Jul; 127(2):151-61. doi: 10.1016/s0009-2797(00)00179-4. [PMID: 10936230]
  • Y Fukui, Y Kikuchi, H Kondo, S Mizushima. Fertilizability and developmental capacity of individually cultured bovine oocytes. Theriogenology. 2000 May; 53(8):1553-65. doi: 10.1016/s0093-691x(00)00297-1. [PMID: 10883843]
  • E T Donnelly, N McClure, S E Lewis. Glutathione and hypotaurine in vitro: effects on human sperm motility, DNA integrity and production of reactive oxygen species. Mutagenesis. 2000 Jan; 15(1):61-8. doi: 10.1093/mutage/15.1.61. [PMID: 10640532]
  • D Izquierdo, P Villamediana, M T Paramio. Effect of culture media on embryo development from prepubertal goat IVM-IVF oocytes. Theriogenology. 1999 Oct; 52(5):847-61. doi: 10.1016/s0093-691x(99)00177-6. [PMID: 10735125]
  • D Izquierdo, P Villamediana, M J Palomo, T Mogas, M T Paramio. Effect of sperm capacitation and fertilization media on IVF and early embryo development of prepubertal goat oocytes. Theriogenology. 1998 Jun; 49(8):1501-13. doi: 10.1016/s0093-691x(98)00096-x. [PMID: 10732014]
  • S Duprè, M Costa, A Spirito, G Pitari, P Rossi, F Amicarelli. Hypotaurine protection on cell damage by H2O2 and on protein oxidation by Cu+2 and H2O2. Advances in experimental medicine and biology. 1998; 442(?):17-23. doi: 10.1007/978-1-4899-0117-0_3. [PMID: 9635010]
  • H S Brand, G G Jörning, R A Chamuleau. Changes in urinary taurine and hypotaurine excretion after two-thirds hepatectomy in the rat. Amino acids. 1998; 15(4):373-83. doi: 10.1007/bf01320901. [PMID: 9891761]
  • T Togawa, A Ohsawa, K Kawanabe, S Tanabe. Simultaneous determination of cysteine sulfinic acid and hypotaurine in rat tissues by column-switching high-performance liquid chromatography with electrochemical detection. Journal of chromatography. B, Biomedical sciences and applications. 1997 Dec; 704(1-2):83-8. doi: 10.1016/s0378-4347(97)00449-0. [PMID: 9518181]
  • M Kalic, G Kamp, J Lauterwein. Nuclear magnetic resonance studies of boar seminal plasma. Problems encountered in the identification of small molecules: hypotaurine and carnitine. NMR in biomedicine. 1997 Oct; 10(7):341-7. doi: 10.1002/(sici)1099-1492(199710)10:7<341::aid-nbm464>3.0.co;2-m. [PMID: 9471125]
  • X Shi, D C Flynn, D W Porter, S S Leonard, V Vallyathan, V Castranova. Efficacy of taurine based compounds as hydroxyl radical scavengers in silica induced peroxidation. Annals of clinical and laboratory science. 1997 Sep; 27(5):365-74. doi: ". [PMID: 9303176]
  • Y Fujitani, K Kasai, S Ohtani, K Nishimura, M Yamada, K Utsumi. Effect of oxygen concentration and free radicals on in vitro development of in vitro-produced bovine embryos. Journal of animal science. 1997 Feb; 75(2):483-9. doi: 10.2527/1997.752483x. [PMID: 9051472]
  • P Guérin, Y Ménézo. Hypotaurine and taurine in gamete and embryo environments: de novo synthesis via the cysteine sulfinic acid pathway in oviduct cells. Zygote (Cambridge, England). 1995 Nov; 3(4):333-43. doi: 10.1017/s0967199400002768. [PMID: 8730898]
  • B Tadolini, G Pintus, G G Pinna, F Bennardini, F Franconi. Effects of taurine and hypotaurine on lipid peroxidation. Biochemical and biophysical research communications. 1995 Aug; 213(3):820-6. doi: 10.1006/bbrc.1995.2203. [PMID: 7654243]
  • L D Jayanthi, S Ramamoorthy, V B Mahesh, F H Leibach, V Ganapathy. Substrate-specific regulation of the taurine transporter in human placental choriocarcinoma cells (JAR). Biochimica et biophysica acta. 1995 May; 1235(2):351-60. doi: 10.1016/0005-2736(95)80024-a. [PMID: 7756345]