Mexiletine (BioDeep_00000002800)

 

Secondary id: BioDeep_00000409002

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


Boehringer ingelheim brand OF mexiletine hydrochloride

化学式: C11H17NO (179.131)
中文名称: 美西律
谱图信息: 最多检出来源 Homo sapiens(blood) 9.36%

分子结构信息

SMILES: CC(N)COC1=C(C)C=CC=C1C
InChI: InChI=1S/C11H17NO/c1-8-5-4-6-9(2)11(8)13-7-10(3)12/h4-6,10H,7,12H2,1-3H3

描述信息

Mexiletine is only found in individuals that have used or taken this drug. It is an antiarrhythmic agent pharmacologically similar to lidocaine. It may have some anticonvulsant properties. [PubChem]Mexiletine, like lidocaine, inhibits the inward sodium current required for the initiation and conduction of impulses, thus reducing the rate of rise of the action potential, Phase 0. It achieves this reduced sodium current by inhibiting sodium channels. Mexiletine decreases the effective refractory period (ERP) in Purkinje fibers in the heart. The decrease in ERP is of lesser magnitude than the decrease in action potential duration (APD), which results in an increase in the ERP/APD ratio. It does not significantly affect resting membrane potential or sinus node automaticity, left ventricular function, systolic arterial blood pressure, atrioventricular (AV) conduction velocity, or QRS or QT intervals
C - Cardiovascular system > C01 - Cardiac therapy > C01B - Antiarrhythmics, class i and iii > C01BB - Antiarrhythmics, class ib
D002317 - Cardiovascular Agents > D026941 - Sodium Channel Blockers > D061567 - Voltage-Gated Sodium Channel Blockers
C78274 - Agent Affecting Cardiovascular System > C47793 - Antiarrhythmic Agent
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3010
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker

同义名列表

20 个代谢物同义名

Boehringer ingelheim brand OF mexiletine hydrochloride; (2Rs)-1-(2,6-Dimethylphenoxy)-2-aminopropane; Novopharm brand OF mexiletine hydrochloride; (+-)-1-(2,6-Dimethylphenoxy)propan-2-amine; 1-(2,6-Dimethylphenoxy)-2-aminopropane; 1-(2,6-Dimethylphenoxy)-2-propanamine; 1-(2,6-dimethylphenoxy)propan-2-amine; 1-Methyl-2-(2,6-xylyloxy)ethanamine; Mexiletine hydrochloride; Novo mexiletine; Novo-mexiletine; Mexiletinum; Mexiletene; Mexitil PL; Mexilitine; Mexiletina; Mexiletine; Mexityl; Mexitil; Mexiletine



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 AXIN2, CACNA1C, CYP1A1, CYP2D6, DMD, KCNQ1
Peripheral membrane protein 3 CYP1A1, CYP1B1, DMD
Endosome membrane 1 CLCN5
Endoplasmic reticulum membrane 4 CYP1A1, CYP1A2, CYP1B1, CYP2D6
Nucleus 2 AXIN2, DMD
cytosol 3 AXIN2, CLCN5, DMD
dendrite 1 CACNA1C
centrosome 1 AXIN2
nucleoplasm 2 SCN5A, SCNN1G
Cell membrane 8 CACNA1C, CLCN1, CLCN5, KCNH2, KCNQ1, SCN4A, SCN5A, SCN9A
Cytoplasmic side 1 DMD
Cell projection, axon 1 SCN9A
Multi-pass membrane protein 11 CACNA1C, CACNA1I, CLCN1, CLCN5, KCNA3, KCNH2, KCNQ1, SCN4A, SCN5A, SCN9A, SCNN1G
Golgi apparatus membrane 1 CLCN5
Synapse 2 DMD, TAC1
cell junction 1 SCN5A
cell surface 3 DMD, KCNH2, SCN5A
glutamatergic synapse 1 KCNA3
Golgi apparatus 1 CLCN5
Golgi membrane 2 CLCN5, INS
lysosomal membrane 1 CLCN5
mitochondrial inner membrane 1 CYP1A1
neuronal cell body 2 KCNQ1, TAC1
presynaptic membrane 1 KCNA3
sarcolemma 2 DMD, SCN5A
synaptic vesicle 1 CLCN5
Lysosome 1 KCNQ1
plasma membrane 14 AXIN2, CACNA1C, CACNA1I, CLCN1, CLCN5, DMD, KCNA3, KCNH2, KCNQ1, ME2, SCN4A, SCN5A, SCN9A, SCNN1G
Membrane 14 CACNA1C, CACNA1I, CLCN1, CLCN5, CYP1B1, CYP2D6, DMD, KCNA3, KCNH2, KCNQ1, ME2, SCN4A, SCN5A, SCN9A
apical plasma membrane 2 KCNQ1, SCNN1G
axon 3 KCNA3, SCN9A, TAC1
basolateral plasma membrane 1 KCNQ1
caveola 1 SCN5A
extracellular exosome 1 SCNN1G
endoplasmic reticulum 3 CYP2D6, KCNQ1, SCN5A
extracellular space 2 INS, TAC1
perinuclear region of cytoplasm 3 KCNA3, KCNH2, SCN5A
intercalated disc 1 SCN5A
mitochondrion 4 CYP1A1, CYP1B1, CYP2D6, ME2
protein-containing complex 1 DMD
intracellular membrane-bounded organelle 5 CYP1A1, CYP1A2, CYP1B1, CYP2D6, ME2
Microsome membrane 4 CYP1A1, CYP1A2, CYP1B1, CYP2D6
filopodium 1 DMD
postsynaptic density 1 CACNA1C
Secreted 1 INS
extracellular region 2 INS, TAC1
Single-pass membrane protein 2 CYP2D6, ME2
Mitochondrion matrix 1 ME2
mitochondrial matrix 1 ME2
external side of plasma membrane 1 SCNN1G
T-tubule 3 CACNA1C, CLCN1, SCN5A
perikaryon 1 CACNA1C
Z disc 3 CACNA1C, DMD, SCN5A
beta-catenin destruction complex 1 AXIN2
nucleolus 1 SCN5A
Early endosome 2 CLCN5, KCNQ1
apical part of cell 1 CLCN5
postsynaptic membrane 2 DMD, KCNA3
Apical cell membrane 2 KCNQ1, SCNN1G
Cell membrane, sarcolemma 3 CACNA1C, CLCN1, DMD
Cytoplasm, perinuclear region 1 SCN5A
Mitochondrion inner membrane 1 CYP1A1
Membrane raft 3 DMD, KCNA3, KCNQ1
Cytoplasm, cytoskeleton 1 DMD
lateral plasma membrane 2 KCNQ1, SCN5A
Nucleus outer membrane 1 DMD
nuclear outer membrane 1 DMD
Postsynaptic cell membrane 1 DMD
Late endosome 1 KCNQ1
Cell projection, neuron projection 1 SCN9A
neuron projection 1 KCNQ1
ciliary base 1 KCNQ1
cytoskeleton 1 DMD
Basolateral cell membrane 1 KCNQ1
[Isoform 2]: Cell membrane 1 KCNA3
endosome lumen 1 INS
chloride channel complex 1 CLCN1
monoatomic ion channel complex 4 CACNA1C, CLCN1, KCNH2, KCNQ1
Cytoplasmic vesicle membrane 1 KCNQ1
sodium channel complex 1 SCNN1G
Cell projection, dendrite 1 CACNA1C
filopodium membrane 1 DMD
Cell membrane, sarcolemma, T-tubule 3 CACNA1C, CLCN1, SCN5A
inward rectifier potassium channel complex 1 KCNH2
voltage-gated potassium channel complex 3 KCNA3, KCNH2, KCNQ1
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
axon terminus 1 SCN9A
voltage-gated calcium channel complex 2 CACNA1C, CACNA1I
transport vesicle 2 INS, KCNQ1
node of Ranvier 1 SCN9A
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
postsynaptic density membrane 1 CACNA1C
Single-pass type IV membrane protein 1 DMD
calyx of Held 1 KCNA3
costamere 1 DMD
[Isoform 1]: Cell membrane 1 KCNA3
dystrophin-associated glycoprotein complex 1 DMD
cell-substrate junction 1 DMD
voltage-gated sodium channel complex 3 SCN4A, SCN5A, SCN9A
neuron projection terminus 1 DMD
syntrophin complex 1 DMD
[Isoform 3]: Cytoplasm, perinuclear region 1 KCNA3
lumenal side of membrane 1 KCNQ1
basolateral part of cell 1 KCNQ1
L-type voltage-gated calcium channel complex 1 CACNA1C
organelle 1 DMD
plasma membrane bounded cell projection 1 DMD


文献列表

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  • Ravi Bhushan, Vinod Kumar Vashistha. Synthesis of variants of Marfey's reagent having d-amino acids as chiral auxiliaries and liquid-chromatographic enantioseparation of (RS)-Mexiletine in spiked plasma: assessment and comparison with L-amino acid analogs. Journal of chromatography. A. 2015 Jan; 1379(?):43-50. doi: 10.1016/j.chroma.2014.12.033. [PMID: 25576038]
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