Mexiletine (BioDeep_00000409002)
Main id: BioDeep_00000002800
代谢物信息卡片
1-(2,6-Dimethylphenoxy)-2-propanamine
化学式: C11H17NO (179.131)
中文名称: 美西律
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(N)COc(c(C)1)c(C)ccc1
InChI: InChI=1S/C11H17NO/c1-8-5-4-6-9(2)11(8)13-7-10(3)12/h4-6,10H,7,12H2,1-3H3
描述信息
C - Cardiovascular system > C01 - Cardiac therapy > C01B - Antiarrhythmics, class i and iii > C01BB - Antiarrhythmics, class ib
D002317 - Cardiovascular Agents > D026941 - Sodium Channel Blockers > D061567 - Voltage-Gated Sodium Channel Blockers
C78274 - Agent Affecting Cardiovascular System > C47793 - Antiarrhythmic Agent
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker
同义名列表
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:6916
- KEGG: C07220
- KEGGdrug: D08215
- PubChem: 4178
- DrugBank: DB00379
- ChEMBL: CHEMBL558
- MeSH: Mexiletine
- CAS: 718619-78-4
- CAS: 31828-71-4
- MoNA: WA002982
- MoNA: WA002981
- MoNA: WA002980
- MoNA: WA002979
- MoNA: WA002978
- PubChem: 9429
- NIKKAJI: J19.958C
- RefMet: Mexiletine
- KNApSAcK: 6916
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Yu Kang, Jiafu Wei. Mexiletine Suppressed Recurrent Ventricular Tachycardia Triggered by Hemodialysis in an Old Patient with LQT2.
International heart journal.
2019 Sep; 60(5):1189-1191. doi:
10.1536/ihj.18-724. [PMID: 31447465] - Christine L H Snozek, Erin J Kaleta, Paul J Jannetto, Jaclyn J Linkenmeyer, Tanya L Harnish, Jenise Stephen, Loralie J Langman. False-positive amphetamine results on several drug screening platforms due to mexiletine.
Clinical biochemistry.
2018 Aug; 58(?):125-127. doi:
10.1016/j.clinbiochem.2018.05.013. [PMID: 29802836] - Yu-Hsuan Yeh, Wen-Chi Chen, Sarah Y Chang. Surfactant-assisted dispersive liquid-liquid microextraction combined with field-amplified sample stacking in capillary electrophoresis for the determination of mexiletine and lidocaine.
Journal of separation science.
2017 Jun; 40(11):2406-2415. doi:
10.1002/jssc.201700042. [PMID: 28378407] - Mariagrazia Roselli, Alessia Carocci, Roberta Budriesi, Matteo Micucci, Maddalena Toma, Lorenzo Di Cesare Mannelli, Angelo Lovece, Alessia Catalano, Maria Maddalena Cavalluzzi, Claudio Bruno, Annalisa De Palma, Marialessandra Contino, Maria Grazia Perrone, Nicola Antonio Colabufo, Alberto Chiarini, Carlo Franchini, Carla Ghelardini, Solomon Habtemariam, Giovanni Lentini. Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues.
European journal of medicinal chemistry.
2016 Oct; 121(?):300-307. doi:
10.1016/j.ejmech.2016.05.046. [PMID: 27267000] - Quan M Bui, Larry A Allen, Andrew A Monte, Robert L Page, Colleen K McIlvennan. Amphetamine-positive urine drug screens in the setting of mexiletine use: A case series.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.
2016 08; 35(8):1045-8. doi:
10.1016/j.healun.2016.05.004. [PMID: 27287628] - Michael D Weiss, Eric A Macklin, Zachary Simmons, Angela S Knox, David J Greenblatt, Nazem Atassi, Michael Graves, Nicholas Parziale, Johnny S Salameh, Colin Quinn, Robert H Brown, Jane B Distad, Jaya Trivedi, Jeremy M Shefner, Richard J Barohn, Alan Pestronk, Andrea Swenson, Merit E Cudkowicz. A randomized trial of mexiletine in ALS: Safety and effects on muscle cramps and progression.
Neurology.
2016 Apr; 86(16):1474-81. doi:
10.1212/wnl.0000000000002507. [PMID: 26911633] - Matthew H Slawson, Kamisha L Johnson-Davis. Quantitation of Flecainide, Mexiletine, Propafenone, and Amiodarone in Serum or Plasma Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS).
Methods in molecular biology (Clifton, N.J.).
2016; 1383(?):11-9. doi:
10.1007/978-1-4939-3252-8_2. [PMID: 26660169] - Ravi Bhushan, Vinod Kumar Vashistha. Synthesis of variants of Marfey's reagent having d-amino acids as chiral auxiliaries and liquid-chromatographic enantioseparation of (RS)-Mexiletine in spiked plasma: assessment and comparison with L-amino acid analogs.
Journal of chromatography. A.
2015 Jan; 1379(?):43-50. doi:
10.1016/j.chroma.2014.12.033. [PMID: 25576038] - Alessia Catalano, Alessia Carocci, Maria Stefania Sinicropi. Mexiletine metabolites: a review.
Current medicinal chemistry.
2015; 22(11):1400-13. doi:
10.2174/0929867322666150227145412. [PMID: 25723511] - Lushan Yu, Yanjun Hong, Li Li, Yingxiu Jin, Mingyue Zheng, Hualiang Jiang, Su Zeng. Enantioselective drug-protein interaction between mexiletine and plasma protein.
The Journal of pharmacy and pharmacology.
2012 Jun; 64(6):792-801. doi:
10.1111/j.2042-7158.2012.01487.x. [PMID: 22571257] - Da Shi, Yin-xiu Jin, Yi-hong Tang, Hai-hong Hu, Si-yun Xu, Lu-shan Yu, Hui-di Jiang, Su Zeng. Stereoselective binding of mexiletine and ketoprofen enantiomers with human serum albumin domains.
Acta pharmacologica Sinica.
2012 May; 33(5):710-6. doi:
10.1038/aps.2012.8. [PMID: 22555373] - Anna R M Gelzer, Marc S Kraus, Mark Rishniw, Shari A Hemsley, N Sydney Moïse. Combination therapy with mexiletine and sotalol suppresses inherited ventricular arrhythmias in German shepherd dogs better than mexiletine or sotalol monotherapy: a randomized cross-over study.
Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology.
2010 Aug; 12(2):93-106. doi:
10.1016/j.jvc.2010.06.001. [PMID: 20663731] - Kenji Momo, Masato Homma, Yoshiko Osaka, Shin-ichi Inomata, Makoto Tanaka, Yukinao Kohda. Effects of mexiletine, a CYP1A2 inhibitor, on tizanidine pharmacokinetics and pharmacodynamics.
Journal of clinical pharmacology.
2010 Mar; 50(3):331-7. doi:
10.1177/0091270009341961. [PMID: 19789372] - Naoko Kobayashi, Aoi Miyamoto, Kazuo Uchikura. Column-switching HPLC determination of mexiletine using tris(bipyridine)ruthenium(III) electrogenerated chemiluminescence and precolumn derivatization with divinylsulfone.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2010; 26(12):1289-94. doi:
10.2116/analsci.26.1289. [PMID: 21157099] - Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance.
Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
10.1021/jm900403j. [PMID: 19445515] - Ana Leonor Pardo Campos Godoy, Caio Cesar Parisi, Maria Paula Marques, Eduardo Barbosa Coelho, Vera Lucia Lanchote. Enantioselective determination of mexiletine and its metabolites p-hydroxymexiletine and hydroxymethylmexiletine in rat plasma by normal-phase liquid chromatography-tandem mass spectrometry: application to pharmacokinetics.
Chirality.
2009 Jul; 21(7):648-56. doi:
10.1002/chir.20650. [PMID: 18973279] - Eftychia N Koini, Panagiota Papazafiri, Athanasios Vassilopoulos, Maria Koufaki, Zoltán Horváth, István Koncz, László Virág, Gy J Papp, Andràs Varró, Theodora Calogeropoulou. 5,7,8-Trimethyl-benzopyran and 5,7,8-trimethyl-1,4-benzoxazine aminoamide derivatives as novel antiarrhythmics against ischemia-reperfusion injury.
Journal of medicinal chemistry.
2009 Apr; 52(8):2328-40. doi:
10.1021/jm801228h. [PMID: 19309156] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Han Liu, Fang Feng, Ming Ma, Shuangjin Cui, Darong Xie, Sizhi Xu. Pharmacokinetic study of three cardiovascular drugs by high-performance liquid chromatography using pre-column derivatization with 9,10-anthraquinone-2-sulfonyl chloride.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Oct; 858(1-2):42-8. doi:
10.1016/j.jchromb.2007.08.004. [PMID: 17766197] - Ozkan Ates, Suleyman R Cayli, Ilal Gurses, Yusuf Turkoz, Ozcan Tarim, Celal O Cakir, Ayhan Kocak. Comparative neuroprotective effect of sodium channel blockers after experimental spinal cord injury.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia.
2007 Jul; 14(7):658-65. doi:
10.1016/j.jocn.2006.03.023. [PMID: 17532502] - B Atalay, H Caner, A Can, M Cekinmez. Attenuation of microtubule associated protein-2 degradation after mild head injury by mexiletine and calpain-2 inhibitor.
British journal of neurosurgery.
2007 Jun; 21(3):281-7. doi:
10.1080/02688690701364781. [PMID: 17612919] - Shuijun Li, Gangyi Liu, Jingying Jia, Yun Liu, Cheng Pan, Chen Yu, Yongbao Cai, Jianying Ren. Simultaneous determination of ten antiarrhythic drugs and a metabolite in human plasma by liquid chromatography--tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Mar; 847(2):174-81. doi:
10.1016/j.jchromb.2006.10.013. [PMID: 17113839] - Orhan Sen, Hakan Caner, M Volkan Aydin, Ozlem Ozen, Basar Atalay, Nur Altinors, Murad Bavbek. The effect of mexiletine on the level of lipid peroxidation and apoptosis of endothelium following experimental subarachnoid hemorrhage.
Neurological research.
2006 Dec; 28(8):859-63. doi:
10.1179/016164106x115099. [PMID: 17288746] - Hiroto Eguchi, Akira Tsujino, Muneshige Kaibara, Hideki Hayashi, Susumu Shirabe, Kohtaro Taniyama, Katsumi Eguchi. Acetazolamide acts directly on the human skeletal muscle chloride channel.
Muscle & nerve.
2006 Sep; 34(3):292-7. doi:
10.1002/mus.20585. [PMID: 16770776] - Thomas Weiser. Comparison of the effects of four Na+ channel analgesics on TTX-resistant Na+ currents in rat sensory neurons and recombinant Nav1.2 channels.
Neuroscience letters.
2006 Mar; 395(3):179-84. doi:
10.1016/j.neulet.2005.10.058. [PMID: 16293367] - Leigh D Plant, Peter N Bowers, Qianyong Liu, Thomas Morgan, Tingting Zhang, Matthew W State, Weidong Chen, Rick A Kittles, Steve A N Goldstein. A common cardiac sodium channel variant associated with sudden infant death in African Americans, SCN5A S1103Y.
The Journal of clinical investigation.
2006 Feb; 116(2):430-5. doi:
10.1172/jci25618. [PMID: 16453024] - Line Labbé, N Michelle Robitaille, Christophe Lefez, Diane Potvin, Marcel Gilbert, Gilles O'Hara, Jacques Turgeon. Effects of ciprofloxacin on the stereoselective disposition of mexiletine in man.
Therapeutic drug monitoring.
2004 Oct; 26(5):492-8. doi:
10.1097/00007691-200410000-00006. [PMID: 15385831] - Hui Xu, Xiaodong Yu, Hongyuan Chen. Enantiomeric separation of basic drugs with partially filled serum albumin as chiral selector in capillary electrophoresis.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2004 Oct; 20(10):1409-13. doi:
10.2116/analsci.20.1409. [PMID: 15524192] - H Caner, A Can, B Atalay, B Erdogan, A H Albayrak, K Kilinc, M Bavbek, N Altinors. Early effects of mild brain trauma on the cytoskeletal proteins neurofilament160 and MAP2, and the preventive effects of mexilitine.
Acta neurochirurgica.
2004 Jun; 146(6):611-21; discussion 621. doi:
10.1007/s00701-003-0209-9. [PMID: 15168230] - Pekka Suomalainen, Christoffer Johans, Tim Söderlund, Paavo K J Kinnunen. Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Journal of medicinal chemistry.
2004 Mar; 47(7):1783-8. doi:
10.1021/jm0309001. [PMID: 15027870] - Jingzu Zhang, Wenhua Xu. Frequent ventricular extrasystole treated by needling neiguan (PC 6) plus oral administration of mexiletine--a report of 30 cases.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2004 Mar; 24(1):40-1. doi:
. [PMID: 15119171] - Franco Lombardo, R Scott Obach, Marina Y Shalaeva, Feng Gao. Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Journal of medicinal chemistry.
2004 Feb; 47(5):1242-50. doi:
10.1021/jm030408h. [PMID: 14971904] - Ging Kuo Wang, Corinna Russell, Sho-Ya Wang. Mexiletine block of wild-type and inactivation-deficient human skeletal muscle hNav1.4 Na+ channels.
The Journal of physiology.
2004 Feb; 554(Pt 3):621-33. doi:
10.1113/jphysiol.2003.054973. [PMID: 14608007] - Sumiyoshi Kiguchi, Takahiro Imamura, Kiyoshi Ichikawa, Masami Kojima. Oxcarbazepine antinociception in animals with inflammatory pain or painful diabetic neuropathy.
Clinical and experimental pharmacology & physiology.
2004 Jan; 31(1-2):57-64. doi:
10.1111/j.1440-1681.2004.03950.x. [PMID: 14756685] - S-Y Wang, E Moczydlowski, G Wang. Inactivation-deficient human skeletal muscle Na+ channels (hNav1.4-L443C/A444W) in stably transfected HEK-293 cells.
Receptors & channels.
2004; 10(3-4):131-8. doi:
10.1080/10606820490514914. [PMID: 15512848] - Ambrus Toth, Robert Halmosi, Krisztina Kovacs, Peter Deres, Tamas Kalai, Kalman Hideg, Kalman Toth, Balazs Sumegi. Akt activation induced by an antioxidant compound during ischemia-reperfusion.
Free radical biology & medicine.
2003 Nov; 35(9):1051-63. doi:
10.1016/s0891-5849(03)00467-2. [PMID: 14572608] - Ahmet Menkü, R Kemal Koç, Vatan Tayfur, Recep Saraymen, Figen Narin, Hidayet Akdemir. Effects of mexiletine, ginkgo biloba extract (EGb 761), and their combination on experimental head injury.
Neurosurgical review.
2003 Oct; 26(4):288-91. doi:
10.1007/s10143-003-0277-6. [PMID: 12884054] - Masahiro Otani, Tsuyoshi Fukuda, Masakazu Naohara, Hiromi Maune, Chiaki Senda, Isamu Yamamoto, Junichi Azuma. Impact of CYP2D6*10 on mexiletine pharmacokinetics in healthy adult volunteers.
European journal of clinical pharmacology.
2003 Sep; 59(5-6):395-9. doi:
10.1007/s00228-003-0656-5. [PMID: 12937870] - C Senda, S Toda, M Tateishi, K Kobayashi, T Igarashi, K Chiba. Mexiletine carbonyloxy beta-D-glucuronide: a novel metabolite in human urine.
Xenobiotica; the fate of foreign compounds in biological systems.
2003 Aug; 33(8):871-84. doi:
10.1080/0049825031000140904. [PMID: 12936706] - Tetsuya Saita, Hiroshi Fujito, Masato Mori. Development of enzyme-linked immunosorbent assay for therapeutic drug monitoring of mexiletine.
Biological & pharmaceutical bulletin.
2003 Jun; 26(6):761-5. doi:
10.1248/bpb.26.761. [PMID: 12808282] - Hui Zhang, Chen Yu, Gang-yi Liu, Jing-ying Jia, You-cai Hong, Xiu-rong Xu. [HPLC-fluorescent spectrometric determination of serum mexiletine concentration after derivatization with fluram].
Yao xue xue bao = Acta pharmaceutica Sinica.
2003 Mar; 38(3):215-7. doi:
NULL. [PMID: 12830720] - Carmen R Valdivia, Michael J Ackerman, David J Tester, Tomoyuki Wada, Jorge McCormack, Bin Ye, Jonathan C Makielski. A novel SCN5A arrhythmia mutation, M1766L, with expression defect rescued by mexiletine.
Cardiovascular research.
2002 Aug; 55(2):279-89. doi:
10.1016/s0008-6363(02)00445-5. [PMID: 12123767] - Franco Lombardo, R Scott Obach, Marina Y Shalaeva, Feng Gao. Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Journal of medicinal chemistry.
2002 Jun; 45(13):2867-76. doi:
10.1021/jm0200409. [PMID: 12061889] - Yorinobu Maeda, Sachiyo Funakoshi, Mamoru Nakamura, Masataka Fukuzawa, Yukimasa Kugaya, Miho Yamasaki, Satsuki Tsukiai, Teruo Murakami, Mikihisa Takano. Possible mechanism for pharmacokinetic interaction between lidocaine and mexiletine.
Clinical pharmacology and therapeutics.
2002 May; 71(5):389-97. doi:
10.1067/mcp.2002.124077. [PMID: 12011825] - Emi Yonezawa, Kana Matsumoto, Kazuyuki Ueno, Miho Tachibana, Hiroshi Hashimoto, Kazuo Komamura, Shiro Kamakura, Kunio Miyatake, Kazuhiko Tanaka. Lack of interaction between amiodarone and mexiletine in cardiac arrhythmia patients.
Journal of clinical pharmacology.
2002 Mar; 42(3):342-6. doi:
10.1177/00912700222011265. [PMID: 11865972] - Hiroyuki Kawagoe, Kaoru Yamaoka, Eiji Kinoshita, Yoshinori Fujimoto, Hiroshi Maejima, Tsunetsugu Yuki, Issei Seyama. Molecular basis for exaggerated sensitivity to mexiletine in the cardiac isoform of the fast Na channel.
FEBS letters.
2002 Feb; 513(2-3):235-41. doi:
10.1016/s0014-5793(02)02320-7. [PMID: 11904157] - Kazuyuki Ueno, Akira Tamamura, Kana Matsumoto, Kazuo Komamura, Shiro Kamakura, Kunio Miyatake, Masahiko Shibakawa. Evaluation of mexiletine clearance in a Japanese population.
The Annals of pharmacotherapy.
2002 Feb; 36(2):241-5. doi:
10.1345/aph.10188. [PMID: 11847941] - Mitsuhiro Nishizaki, Takashi Ashikaga, Noriyoshi Yamawake, Hiroyuki Fujii, Masataka Arita, Naokata Sumitomo, Harumizu Sakurada, Masayasu Hiraoka. Effects of glucose-induced insulin secretion on ventricular repolarization in patients with congenital long QT syndrome.
Circulation journal : official journal of the Japanese Circulation Society.
2002 Jan; 66(1):35-40. doi:
10.1253/circj.66.35. [PMID: 11999663] - M Kusumoto, K Ueno, A Oda, K Takeda, K Mashimo, K Takaya, Y Fujimura, T Nishihori, K Tanaka. Effect of fluvoxamine on the pharmacokinetics of mexiletine in healthy Japanese men.
Clinical pharmacology and therapeutics.
2001 Mar; 69(3):104-7. doi:
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The New England journal of medicine.
2000 Dec; 343(26):1971-2. doi:
10.1056/nejm200012283432616. [PMID: 11186678] - M S Wallace, S Magnuson, B Ridgeway. Efficacy of oral mexiletine for neuropathic pain with allodynia: a double-blind, placebo-controlled, crossover study.
Regional anesthesia and pain medicine.
2000 Sep; 25(5):459-67. doi:
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Regional anesthesia and pain medicine.
2000 Sep; 25(5):468-74. doi:
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Clinical pharmacology and therapeutics.
2000 Jul; 68(1):44-57. doi:
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Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology.
2000 Feb; 20(1):11-6. doi:
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Thorax.
2000 Feb; 55(2):126-8. doi:
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Neuromuscular disorders : NMD.
2000 Jan; 10(1):31-9. doi:
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Clinical pharmacokinetics.
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Journal of neurosurgery.
1999 Oct; 91(2 Suppl):200-4. doi:
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Japanese journal of pharmacology.
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Therapeutic drug monitoring.
1999 Apr; 21(2):191-9. doi:
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European journal of drug metabolism and pharmacokinetics.
1999 Apr; 24(2):149-53. doi:
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Journal of the neurological sciences.
1999 Jan; 162(2):162-8. doi:
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Chirality.
1999; 11(1):29-32. doi:
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Chirality.
1999; 11(2):85-90. doi:
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Naunyn-Schmiedeberg's archives of pharmacology.
1998 Dec; 358(6):649-56. doi:
10.1007/pl00005307. [PMID: 9879724] - H Morita, T Higashizawa, H Yuasa, K Hiramatsu, Y Koga. [Evaluation of preincisional mexiletine administration to alleviate postoperative pain].
Masui. The Japanese journal of anesthesiology.
1998 Nov; 47(11):1311-4. doi:
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Movement disorders : official journal of the Movement Disorder Society.
1998 Nov; 13(6):934-40. doi:
10.1002/mds.870130612. [PMID: 9827618] - R Fleischhauer, N Mitrovic, F Deymeer, F Lehmann-Horn, H Lerche. Effects of temperature and mexiletine on the F1473S Na+ channel mutation causing paramyotonia congenita.
Pflugers Archiv : European journal of physiology.
1998 Oct; 436(5):757-65. doi:
10.1007/s004240050699. [PMID: 9716710] - K Uenaka, T Koue, T Iwai, M Shibakawa, K Ueno. Population pharmacokinetic analysis of mexiletine in adult arrhythmic patients in Japanese population.
Biological & pharmaceutical bulletin.
1998 Aug; 21(8):844-6. doi:
10.1248/bpb.21.844. [PMID: 9743254] - A Dasgupta, P Appenzeller, J Moore. Gas chromatography-electron ionization and chemical ionization mass spectrometric analysis of serum mexiletine concentration after derivatization with 2,2,2-trichloroethyl chloroformate: a novel derivative.
Therapeutic drug monitoring.
1998 Jun; 20(3):313-8. doi:
10.1097/00007691-199806000-00012. [PMID: 9631929] - V L Lanchote, E J Cesarino, V J Santos, A V Moraes Júnior, A M Zanardi, S R Santos. Stereoselective metabolism of mexiletine in Chagasic women with ventricular arrhythmias.
European journal of drug metabolism and pharmacokinetics.
1998 Apr; 23(2):259-66. doi:
10.1007/bf03189349. [PMID: 9725491] - A Dasgupta, O Yousef. Gas chromatographic-mass spectrometric determination of serum mexiletine concentration after derivatization with perfluorooctanoyl chloride, a new derivative.
Journal of chromatography. B, Biomedical sciences and applications.
1998 Feb; 705(2):283-8. doi:
10.1016/s0378-4347(97)00528-8. [PMID: 9521565] - M Kusumoto, K Ueno, K Tanaka, K Takeda, K Mashimo, T Kameda, Y Fujimura, M Shibakawa. Lack of pharmacokinetic interaction between mexiletine and omeprazole.
The Annals of pharmacotherapy.
1998 Feb; 32(2):182-4. doi:
10.1345/aph.17177. [PMID: 9496401] - P Oskarsson, J G Ljunggren, P E Lins. Efficacy and safety of mexiletine in the treatment of painful diabetic neuropathy. The Mexiletine Study Group.
Diabetes care.
1997 Oct; 20(10):1594-7. doi:
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Pacing and clinical electrophysiology : PACE.
1997 Aug; 20(8 Pt 2):2052-7. doi:
10.1111/j.1540-8159.1997.tb03626.x. [PMID: 9272507] - P Petovský, J Malý. [A case of fatal poisoning with the anti-arrhythmia agents Katen and Neo-Gilurytmal].
Soudni lekarstvi.
1997 May; 42(2):18-20. doi:
NULL. [PMID: 9340789] - Y Sata, M Aihara, K Hatakeyama, Y Hinohara, Y Kamiya, C Shimoda, H Kanemura, S Nakazawa. [Efficacy and side effects of lidocaine by intravenous drip infusion in children with intractable seizures].
No to hattatsu = Brain and development.
1997 Jan; 29(1):39-44. doi:
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Chirality.
1997; 9(8):732-8. doi:
10.1002/(sici)1520-636x(1997)9:8<732::aid-chir4>3.0.co;2-7. [PMID: 9435098] - V L Lanchote, P S Bonato, S A Dreossi, P V Gonçalves, E J Cesarino, C Bertucci. High-performance liquid chromatographic determination of mexiletine enantiomers in plasma using direct and indirect enantioselective separations.
Journal of chromatography. B, Biomedical applications.
1996 Oct; 685(2):281-9. doi:
10.1016/s0378-4347(96)00195-8. [PMID: 8953169] - H Groeben, W M Foster, R H Brown. Intravenous lidocaine and oral mexiletine block reflex bronchoconstriction in asthmatic subjects.
American journal of respiratory and critical care medicine.
1996 Oct; 154(4 Pt 1):885-8. doi:
10.1164/ajrccm.154.4.8887580. [PMID: 8887580] - B Knoche, B Gehrcke, W A König, I W Wainer. Determination of the enantiomeric composition of mexiletine and its four hydroxylated metabolites in urine by enantioselective capillary gas chromatography.
Chirality.
1996; 8(1):30-4. doi:
10.1002/(sici)1520-636x(1996)8:1<30::aid-chir7>3.0.co;2-k. [PMID: 8845279] - D W Kwok, C R Kerr, K M McErlane. Pharmacokinetics of mexiletine enantiomers in healthy human subjects. A study of the in vivo serum protein binding, salivary excretion and red blood cell distribution of the enantiomers.
Xenobiotica; the fate of foreign compounds in biological systems.
1995 Nov; 25(10):1127-42. doi:
10.3109/00498259509061913. [PMID: 8578769] - F Chézalviel-Guilbert, J M Davy, J M Poirier, J Weissenburger. Mexiletine antagonizes effects of sotalol on QT interval duration and its proarrhythmic effects in a canine model of torsade de pointes.
Journal of the American College of Cardiology.
1995 Sep; 26(3):787-92. doi:
10.1016/0735-1097(95)00234-u. [PMID: 7642874] - O Kakinohana, Y Okuda. [The plasma concentration measurement of local anesthetics, thiobarbiturates and mexiletine by HPLC with automatic pre-treatment system].
Masui. The Japanese journal of anesthesiology.
1995 Aug; 44(8):1165-70. doi:
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Internal medicine (Tokyo, Japan).
1995 Jun; 34(6):577-9. doi:
10.2169/internalmedicine.34.577. [PMID: 7549147] - R H Brown, W Robbins, P Staats, C Hirshman. Prevention of bronchoconstriction by an orally active local anesthetic.
American journal of respiratory and critical care medicine.
1995 Apr; 151(4):1239-43. doi:
10.1164/ajrccm/151.4.1239. [PMID: 7697259] - V Hutt, G Pabst, Z Salama, J Kappler, H Jaeger. [The pharmacokinetics and bioavailability of a new mexiletine preparation in healthy volunteers].
Arzneimittel-Forschung.
1995 Mar; 45(3):254-7. doi:
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Journal of cardiovascular pharmacology.
1995 Feb; 25(2):194-9. doi:
10.1097/00005344-199502000-00003. [PMID: 7752644] - M B Minnigh, J D Alvin, M A Zemaitis. Determination of plasma mexiletine levels with gas chromatography-mass spectrometry and selected-ion monitoring.
Journal of chromatography. B, Biomedical applications.
1994 Dec; 662(1):118-22. doi:
10.1016/0378-4347(94)00395-5. [PMID: 7894684] - D K Kowk, L Igwemezie, C R Kerr, K M McErlane. High-performance liquid chromatographic analysis using a highly sensitive fluorogenic reagent, 2-anthroyl chloride, and stereoselective determination of the enantiomers of mexiletine in human serum.
Journal of chromatography. B, Biomedical applications.
1994 Nov; 661(2):271-80. doi:
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Journal of analytical toxicology.
1994 Oct; 18(6):346-7. doi:
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Journal of neural transmission. Supplementum.
1994; 41(?):427-32. doi:
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Journal of toxicology. Clinical toxicology.
1994; 32(6):731-6. doi:
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Journal of pharmaceutical and biomedical analysis.
1993 Nov; 11(11-12):1173-9. doi:
10.1016/0731-7085(93)80101-6. [PMID: 8123732] - Z Abolfathi, C Fiset, M Gilbert, K Moerike, P M Bélanger, J Turgeon. Role of polymorphic debrisoquin 4-hydroxylase activity in the stereoselective disposition of mexiletine in humans.
The Journal of pharmacology and experimental therapeutics.
1993 Sep; 266(3):1196-201. doi:
. [PMID: 8371133] - D G Freitag, R T Foster, R T Coutts, F M Pasutto. High-performance liquid chromatographic method for resolving the enantiomers of mexiletine and two major metabolites isolated from microbial fermentation media.
Journal of chromatography.
1993 Jul; 616(2):253-9. doi:
10.1016/0378-4347(93)80393-i. [PMID: 8376507] - S G Ji, Q H Kong, X L Li, P Li. Gas chromatographic determination of mexiletine in human plasma with flame ionization detection after reaction with carbon disulphide.
Biomedical chromatography : BMC.
1993 Jul; 7(4):196-9. doi:
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Pacing and clinical electrophysiology : PACE.
1993 Apr; 16(4 Pt 1):778-88. doi:
10.1111/j.1540-8159.1993.tb01658.x. [PMID: 7683805]
