[8]-Shogaol (BioDeep_00000002771)
Main id: BioDeep_00000229873
human metabolite PANOMIX_OTCML-2023 Chemicals and Drugs Antitumor activity
代谢物信息卡片
1-(4-Hydroxy-3-methoxyphenyl)-4-dodecen-3-one, 9CI
化学式: C17H24O3 (276.1725)
中文名称: 6-姜烯酚
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCC=CC(=O)CCC1=CC(=C(C=C1)O)OC
InChI: InChI=1S/C17H24O3/c1-3-4-5-6-7-8-15(18)11-9-14-10-12-16(19)17(13-14)20-2/h7-8,10,12-13,19H,3-6,9,11H2,1-2H3
描述信息
1-(3,4-Dimethoxyphenyl)-4-decen-3-one is found in ginger. 1-(3,4-Dimethoxyphenyl)-4-decen-3-one is a constituent of ginger (Zingiber officinale) [DFC] (Yannai, Shmuel. (2004) Dictionary of food compounds with CD-ROM: Additives, flavors, and ingredients. Boca Raton: Chapman & Hall/CRC.).
Constituent of grains of paradise (Amomum melegueta) and Zingiber officinale (ginger) [DFC]
C1907 - Drug, Natural Product > C28269 - Phytochemical
D009676 - Noxae > D009153 - Mutagens
Shogaol ([6]-Shogaol), an active compound isolated from Ginger (Zingiber officinale Rosc), exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.
Shogaol ([6]-Shogaol), an active compound isolated from Ginger (Zingiber officinale Rosc), exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.
同义名列表
数据库引用编号
21 个数据库交叉引用编号
- ChEBI: CHEBI:10138
- KEGG: C10494
- PubChem: 5281794
- PubChem: 11152
- HMDB: HMDB0031463
- Metlin: METLIN68362
- ChEMBL: CHEMBL25948
- KNApSAcK: C00035688
- KNApSAcK: C00002774
- KNApSAcK: C00031419
- foodb: FDB011861
- chemspider: 10679
- CAS: 23513-13-5
- CAS: 36700-45-5
- CAS: 555-66-8
- PMhub: MS000004854
- PubChem: 12677
- 3DMET: B03899
- NIKKAJI: J6.474B
- medchemexpress: HY-14616
- KNApSAcK: 10138
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
7 个相关的物种来源信息
- 637930 - Aframomum melegueta:
- 36622 - Chaenomeles sinensis: 10.1021/ACS.JNATPROD.5B00090
- 9606 - Homo sapiens: -
- 33090 - Plants: -
- 94328 - Zingiber officinale:
- 94328 - Zingiber officinale Rosc.: -
- 94328 - Zingiber Officinale Roscoe: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yoon-Tae Kim, Jae-Sung Shin, Sang-Jin Ye, Ji Hye Kim, Seok Hyun Eom, Moo-Yeol Baik. Conversion of gingerols to shogaols in ginger (Zingiber officinale roscoe) by puffing.
Food chemistry.
2024 Sep; 452(?):139425. doi:
10.1016/j.foodchem.2024.139425. [PMID: 38744128] - Xiao-Lan Cheng, Yong-Lan Ruan, Jing-Ya Dai, Hai-Zhen Fan, Jin-Ying Ling, Jiao Chen, Wu-Guang Lu, Xue-Jiao Gao, Peng Cao. 8-shogaol derived from dietary ginger alleviated acute and inflammatory pain by targeting TRPV1.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jun; 128(?):155500. doi:
10.1016/j.phymed.2024.155500. [PMID: 38484627] - Kitti Pázmándi, Beatrix Ágics, Attila Gábor Szöllősi, Attila Bácsi, Tünde Fekete. Ginger-derived bioactive compounds attenuate the Toll-like receptor mediated responses of human dendritic cells.
European journal of pharmacology.
2024 Mar; 967(?):176399. doi:
10.1016/j.ejphar.2024.176399. [PMID: 38331338] - Ah Young Yang, Kiryeong Kim, Hyun Hee Kwon, Jaechan Leem, Jeong Eun Song. 6-Shogaol Ameliorates Liver Inflammation and Fibrosis in Mice on a Methionine- and Choline-Deficient Diet by Inhibiting Oxidative Stress, Cell Death, and Endoplasmic Reticulum Stress.
Molecules (Basel, Switzerland).
2024 Jan; 29(2):. doi:
10.3390/molecules29020419. [PMID: 38257332] - Mirjana Sulejmanović, Nataša Milić, Ioannis Mourtzinos, Nataša Nastić, Anastasia Kyriakoudi, Jovana Drljača, Senka Vidović. Ultrasound-assisted and subcritical water extraction techniques for maximal recovery of phenolic compounds from raw ginger herbal dust toward in vitro biological activity investigation.
Food chemistry.
2023 Oct; 437(Pt 1):137774. doi:
10.1016/j.foodchem.2023.137774. [PMID: 37866343] - X Zong, Q Ding, X Liu, Q Liu, S Song, X Yan, Y Zhang. Preventive Effect of 6-shogaol on D-galactosamine Induced Hepatotoxicity Through NF-?B/MAPK Signaling Pathway in Rats.
Physiological research.
2023 Aug; 72(4):445-454. doi:
. [PMID: 37795887] - Shuang Pan, Yaming Li, Jinzhao Zhang. 6-Shogaol prevents benzo (A) pyrene-exposed lung carcinogenesis via modulating PRDX1-associated oxidative stress, inflammation, and proliferation in mouse models.
Environmental toxicology.
2023 Aug; ?(?):. doi:
10.1002/tox.23946. [PMID: 37638803] - Wenlin Zhang, Yang Yang, Xuedong Zhu, Suyu Yang, Ximei Liao, Honglei Li, Zhexin Li, Qinhong Liao, Jianmin Tang, Guohua Zhao, Lin Wu. Integrated analyses of metabolomics and transcriptomics reveal the potential regulatory roles of long non-coding RNAs in gingerol biosynthesis.
BMC genomics.
2023 Aug; 24(1):490. doi:
10.1186/s12864-023-09553-5. [PMID: 37633894] - Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products.
ACS pharmacology & translational science.
2023 May; 6(5):683-701. doi:
10.1021/acsptsci.2c00194. [PMID: 37200814] - Bin Li, Yunxiang Wang, Xin Yuan, Guanting Liu, Yunpeng Diao, Jing Liu. 6-Shogaol from Dried Ginger Protects Against Intestinal Ischemia/Reperfusion by Inhibiting Cell Apoptosis via the BDNF/TrkB/PI3K/AKT Pathway.
Molecular nutrition & food research.
2023 Apr; ?(?):e2200773. doi:
10.1002/mnfr.202200773. [PMID: 37118920] - Abdelbaset Mohamed Elasbali, Waleed Abu Al-Soud, Afnan Elayyan Mousa Elayyan, Ziad H Al-Oanzi, Hassan H Alhassan, Bashir M Mohamed, Hamad H Alanazi, Mohammad Saquib Ashraf, Shadman Moiz, Mitesh Patel, Mirav Patel, Mohd Adnan. Integrating network pharmacology approaches for the investigation of multi-target pharmacological mechanism of 6-shogaol against cervical cancer.
Journal of biomolecular structure & dynamics.
2023 Mar; ?(?):1-17. doi:
10.1080/07391102.2023.2191719. [PMID: 36943780] - Wenya Jiao, Yaxin Sang, Xianghong Wang, Shuo Wang. Metabonomics and the gut microbiome analysis of the effect of 6-shogaol on improving obesity.
Food chemistry.
2023 Mar; 404(Pt B):134734. doi:
10.1016/j.foodchem.2022.134734. [PMID: 36327507] - Shoujiao Peng, Shaopeng Yu, Junmin Zhang, Jiange Zhang. 6-Shogaol as a Novel Thioredoxin Reductase Inhibitor Induces Oxidative-Stress-Mediated Apoptosis in HeLa Cells.
International journal of molecular sciences.
2023 Mar; 24(5):. doi:
10.3390/ijms24054966. [PMID: 36902397] - Kanta Keosaeng, Weerasak Songoen, Thitaree Yooboon, Vasakorn Bullangpoti, Wanchai Pluempanupat. Insecticidal activity of isolated gingerols and shogaols from Zingiber officinale Roscoe rhizomes against Spodoptera spp. (Lepidoptera: Noctuidae).
Natural product research.
2023 Feb; 37(4):669-674. doi:
10.1080/14786419.2022.2078818. [PMID: 35608145] - Chang Yu Kan, Jing Xuan H'ng, Andy Goh, Frederick Smales, Eng Lai Tan, Shiming Zhang, Mallikarjuna Rao Pichika, Abhishek Parolia. Effect of Sustained Systemic Administration of Ginger (Z officinale) Rhizome Extracts on Salivary Flow in Mice.
International dental journal.
2023 Feb; 73(1):63-70. doi:
10.1016/j.identj.2022.04.011. [PMID: 35725589] - Jiasheng Li, Ying Zhang, Shurui Liu, Wangjun Li, Yue Sun, Hui Cao, Shumei Wang, Jiang Meng. A network pharmacology integrated pharmacokinetics strategy to investigate the pharmacological mechanism of absorbed components from crude and processed Zingiberis Rhizoma on deficiency-cold and hemorrhagic syndrome.
Journal of ethnopharmacology.
2023 Jan; 301(?):115754. doi:
10.1016/j.jep.2022.115754. [PMID: 36195301] - Nan Li, Xiaojuan Li, Lijuan Deng, Haixin Yang, Zhaohui Gong, Qiang Wang, Dongmei Pan, Shan Zeng, Jiaxu Chen. 6-Shogaol inhibits the proliferation, apoptosis, and migration of rheumatoid arthritis fibroblast-like synoviocytes via the PI3K/AKT/NF-κB pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Jan; 109(?):154562. doi:
10.1016/j.phymed.2022.154562. [PMID: 36610124] - H Li, J Shen, Y Zhang, L Hu, W Luo. 6-Shogaol protects against isoproterenol-induced cardiac injury in rats through attenutating oxidative stress, inflammation, apoptosis and activating nuclear respiratory factor-2/heme oxygenase-1 signaling pathway.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2022 Dec; 73(6):. doi:
10.26402/jpp.2022.6.06. [PMID: 37087565] - Wei-Hao Zhang, Han-Yan Luo, Jing Fang, Chen-Liang Zhao, Kam-Chun Chan, Yui-Man Chan, Cai-Xia Dong, Hu-Biao Chen, Zhong-Zhen Zhao, Song-Lin Li, Jun Xu. Impact of Sulfur Fumigation on Ginger: Chemical and Biological Evidence.
Journal of agricultural and food chemistry.
2022 Oct; 70(39):12577-12586. doi:
10.1021/acs.jafc.2c05710. [PMID: 36130944] - Sara Ishaq, Sohana Siyar, Rabia Basri, Amna Liaqat, Armeen Hameed, Touqeer Ahmed. Neuroprotective effects of Shogaol in metals (Al, As and Pb) and high fat diet induced neuroinflammation and behavior in mice.
Current molecular pharmacology.
2022 Sep; ?(?):. doi:
10.2174/1874467215666220928110557. [PMID: 36173059] - S I Othman, M N Bin-Jumah, R S Suliman, S S Althobaiti, E A Alqhtani, S A Gabr. Gingerol fractions bioactivity against butanone cytotoxicity induced in newborns of mice.
European review for medical and pharmacological sciences.
2022 09; 26(18):6512-6522. doi:
10.26355/eurrev_202209_29750. [PMID: 36196700] - Shuwei Zhang, Emily DiMango, Yingdong Zhu, Tarnjot K Saroya, Charles W Emala, Shengmin Sang. Pharmacokinetics of Gingerols, Shogaols, and Their Metabolites in Asthma Patients.
Journal of agricultural and food chemistry.
2022 Aug; 70(31):9674-9683. doi:
10.1021/acs.jafc.2c03150. [PMID: 35916113] - Jian-Li Qiu, Yu-Na Chai, Feng-Yang Duan, Hui-Juan Zhang, Xiao-Yan Han, Ling-Yan Chen, Fei Duan. 6-Shogaol alleviates CCl4-induced liver fibrosis by attenuating inflammatory response in mice through the NF-κB pathway.
Acta biochimica Polonica.
2022 Apr; 69(2):363-370. doi:
10.18388/abp.2020_5802. [PMID: 35485077] - Wenya Jiao, Si Mi, Yaxin Sang, Qiuxia Jin, Bimal Chitrakar, Xianghong Wang, Shuo Wang. Integrated network pharmacology and cellular assay for the investigation of an anti-obesity effect of 6-shogaol.
Food chemistry.
2022 Apr; 374(?):131755. doi:
10.1016/j.foodchem.2021.131755. [PMID: 34883426] - Chwan-Li Shen, Rui Wang, Guangchen Ji, Moamen M Elmassry, Masoud Zabet-Moghaddam, Heather Vellers, Abdul N Hamood, Xiaoxia Gong, Parvin Mirzaei, Shengmin Sang, Volker Neugebauer. Dietary supplementation of gingerols- and shogaols-enriched ginger root extract attenuate pain-associated behaviors while modulating gut microbiota and metabolites in rats with spinal nerve ligation.
The Journal of nutritional biochemistry.
2022 02; 100(?):108904. doi:
10.1016/j.jnutbio.2021.108904. [PMID: 34748918] - Sowsan Hafuth, Sukhpal Randhawa. Investigating the Anti-Cancer Properties of 6-Shogaol in Zingiber officinale.
Critical reviews in oncogenesis.
2022; 27(3):15-22. doi:
10.1615/critrevoncog.2022045100. [PMID: 37183935] - Naiana da Rosa, Fabiana Durante de Medeiros, Juliana de Oliveira, Ana Olívia Martins Laurentino, Eduardo de Medeiros Peretti, Richard Simon Machado, Millena Pais Lourenço, Thatiany Igreja da Silva, Tamires da Cunha Fernandes, Patrícia Alves Reis, Hugo Caire de Castro Faria Neto, Josiane Somariva Prophiro, Jucélia Jeremias Fortunato, Fabrícia Petronilho. 6-Shogaol Exerts a Neuroprotective Factor in Offspring after Maternal Immune Activation in Rats.
Developmental neuroscience.
2022; 44(1):13-22. doi:
10.1159/000519992. [PMID: 34695825] - Nazanin Momeni Roudsari, Naser-Aldin Lashgari, Saeideh Momtaz, Basil Roufogalis, Amir Hossein Abdolghaffari, Amirhossein Sahebkar. Ginger: A complementary approach for management of cardiovascular diseases.
BioFactors (Oxford, England).
2021 Nov; 47(6):933-951. doi:
10.1002/biof.1777. [PMID: 34388275] - Mi-Gyeong Gwon, Hyemin Gu, Jaechan Leem, Kwan-Kyu Park. Protective Effects of 6-Shogaol, an Active Compound of Ginger, in a Murine Model of Cisplatin-Induced Acute Kidney Injury.
Molecules (Basel, Switzerland).
2021 Sep; 26(19):. doi:
10.3390/molecules26195931. [PMID: 34641472] - Giovanni Schepici, Valentina Contestabile, Andrea Valeri, Emanuela Mazzon. Ginger, a Possible Candidate for the Treatment of Dementias?.
Molecules (Basel, Switzerland).
2021 Sep; 26(18):. doi:
10.3390/molecules26185700. [PMID: 34577171] - Kapil Rai, Narayansing Chhanwal, Nirali N Shah, Rekha S Singhal. Encapsulation of ginger oleoresin in co-crystallized sucrose: development, characterization and storage stability.
Food & function.
2021 Sep; 12(17):7964-7974. doi:
10.1039/d1fo00565k. [PMID: 34254624] - Niramon Utama-Ang, Sirinapa Sida, Phenphichar Wanachantararak, Arthitaya Kawee-Ai. Development of edible Thai rice film fortified with ginger extract using microwave-assisted extraction for oral antimicrobial properties.
Scientific reports.
2021 07; 11(1):14870. doi:
10.1038/s41598-021-94430-y. [PMID: 34290338] - Mai T Abdo, Sherweit H El-Ahmady, Haidy A Gad. Quality control and long-term stability study of ginger from different geographical origins using chemometrics.
Journal of the science of food and agriculture.
2021 Jun; 101(8):3429-3438. doi:
10.1002/jsfa.10973. [PMID: 33289094] - Man-Qian Li, Xue-Yu Hu, Yan-Zhi Wang, Xiao-Juan Zhang, Jian-Peng Li, Zhi-Min Song, Yu-Fei Liu, Wei-Sheng Feng. Qualitative analysis on chemical constituents from different polarity extracted fractions of the pulp and peel of ginger rhizomes by ultra-high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2021 Apr; 35(8):e9029. doi:
10.1002/rcm.9029. [PMID: 33326132] - H-R Kim, Y-B Eom. Antifungal and anti-biofilm effects of 6-shogaol against Candida auris.
Journal of applied microbiology.
2021 Apr; 130(4):1142-1153. doi:
10.1111/jam.14870. [PMID: 32981148] - Soo Liang Ooi, Ron Campbell, Sok Cheon Pak, Terry Golombick, Arumugam Manoharan, Raj Ramakrishna, Vladimir Badmaev, Janet Schloss. Is 6-Shogaol an Effective Phytochemical for Patients With Lower-risk Myelodysplastic Syndrome? A Narrative Review.
Integrative cancer therapies.
2021 Jan; 20(?):15347354211065038. doi:
10.1177/15347354211065038. [PMID: 34930049] - Jing Wang, Yong Chen, Xiaosong Hu, Fengqin Feng, Luyun Cai, Fang Chen. Assessing the Effects of Ginger Extract on Polyphenol Profiles and the Subsequent Impact on the Fecal Microbiota by Simulating Digestion and Fermentation In Vitro.
Nutrients.
2020 Oct; 12(10):. doi:
10.3390/nu12103194. [PMID: 33086593] - Chunhua Yang, Mingzhen Zhang, Sudeep Lama, Lixin Wang, Didier Merlin. Natural-lipid nanoparticle-based therapeutic approach to deliver 6-shogaol and its metabolites M2 and M13 to the colon to treat ulcerative colitis.
Journal of controlled release : official journal of the Controlled Release Society.
2020 07; 323(?):293-310. doi:
10.1016/j.jconrel.2020.04.032. [PMID: 32335157] - Eugene Huh, Jin Gyu Choi, Dongjin Noh, Hyung-Seok Yoo, Jeewon Ryu, Nam-Jung Kim, Hocheol Kim, Myung Sook Oh. Ginger and 6-shogaol protect intestinal tight junction and enteric dopaminergic neurons against 1-methyl-4-phenyl 1,2,3,6-tetrahydropyridine in mice.
Nutritional neuroscience.
2020 Jun; 23(6):455-464. doi:
10.1080/1028415x.2018.1520477. [PMID: 30230979] - Marta Woźniak, Sebastian Makuch, Kinga Winograd, Jerzy Wiśniewski, Piotr Ziółkowski, Siddarth Agrawal. 6-Shogaol enhances the anticancer effect of 5-fluorouracil, oxaliplatin, and irinotecan via increase of apoptosis and autophagy in colon cancer cells in hypoxic/aglycemic conditions.
BMC complementary medicine and therapies.
2020 May; 20(1):141. doi:
10.1186/s12906-020-02913-8. [PMID: 32393373] - Fifteen Aprila Fajrin, Agung Endro Nugroho, Arief Nurrochmad, Rina Susilowati. Ginger extract and its compound, 6-shogaol, attenuates painful diabetic neuropathy in mice via reducing TRPV1 and NMDAR2B expressions in the spinal cord.
Journal of ethnopharmacology.
2020 Mar; 249(?):112396. doi:
10.1016/j.jep.2019.112396. [PMID: 31743763] - Gene T Yocum, Julie J Hwang, Maya Mikami, Jennifer Danielsson, Aisha S Kuforiji, Charles W Emala. Ginger and its bioactive component 6-shogaol mitigate lung inflammation in a murine asthma model.
American journal of physiology. Lung cellular and molecular physiology.
2020 02; 318(2):L296-L303. doi:
10.1152/ajplung.00249.2019. [PMID: 31800263] - Alexandra Simon, András Darcsi, Ágnes Kéry, Eszter Riethmüller. Blood-brain barrier permeability study of ginger constituents.
Journal of pharmaceutical and biomedical analysis.
2020 Jan; 177(?):112820. doi:
10.1016/j.jpba.2019.112820. [PMID: 31476432] - Stefano Dall'Acqua, Iztok Grabnar, Roberto Verardo, Enio Klaric, Luigi Marchionni, Eddie Luidy-Imada, Stefania Sut, Chiara Agostinis, Roberta Bulla, Beatrice Perissutti, Dario Voinovich. Combined extracts of Echinacea angustifolia DC. and Zingiber officinale Roscoe in softgel capsules: Pharmacokinetics and immunomodulatory effects assessed by gene expression profiling.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2019 Dec; 65(?):153090. doi:
10.1016/j.phymed.2019.153090. [PMID: 31557666] - Tae Hyun Lee, Zahra Khan, Sun Yeou Kim, Kang Ro Lee. Thiohydantoin and Hydantoin Derivatives from the Roots of Armoracia rusticana and Their Neurotrophic and Anti-neuroinflammatory Activities.
Journal of natural products.
2019 11; 82(11):3020-3024. doi:
10.1021/acs.jnatprod.9b00527. [PMID: 31625742] - Richard Osae, Cunshan Zhou, Raphael N Alolga, Baoguo Xu, William Tchabo, Ernest Bonah, Evans Adingba Alenyorege, Haile Ma. Effects of Various Nonthermal Pretreatments on the Physicochemical Properties of Dried Ginger (Zingiber officinale Roscoe) Slices from Two Geographical Locations.
Journal of food science.
2019 Oct; 84(10):2847-2858. doi:
10.1111/1750-3841.14790. [PMID: 31573687] - I-Jeng Yeh, Szu-Chia Chen, Meng-Chi Yen, Yen-Hung Wu, Chih-Hsing Hung, Po-Lin Kuo. 6-Shogaol Suppresses 2-Amino-1-Methyl-6-Phenylimidazo [4,5-b] Pyridine (PhIP)-Induced Human 786-O Renal Cell Carcinoma Osteoclastogenic Activity and Metastatic Potential.
Nutrients.
2019 Sep; 11(10):. doi:
10.3390/nu11102306. [PMID: 31569368] - Sang Jun Han, Mihwa Kim, Vivette D D'Agati, H Thomas Lee. 6-Shogaol protects against ischemic acute kidney injury by modulating NF-κB and heme oxygenase-1 pathways.
American journal of physiology. Renal physiology.
2019 09; 317(3):F743-F756. doi:
10.1152/ajprenal.00182.2019. [PMID: 31313953] - Xiaohong Deng, Siwei Zhang, Junzhen Wu, Xianjun Sun, Ziyin Shen, Jingcheng Dong, Jianhua Huang. Promotion of Mitochondrial Biogenesis via Activation of AMPK-PGC1ɑ Signaling Pathway by Ginger (Zingiber officinale Roscoe) Extract, and Its Major Active Component 6-Gingerol.
Journal of food science.
2019 Aug; 84(8):2101-2111. doi:
10.1111/1750-3841.14723. [PMID: 31369153] - Qiuxuan Yang, Qilong Wang, Yingshu Feng, Qiuyu Wei, Congyong Sun, Caleb Kesse Firempong, Michael Adu-Frimpong, Ran Li, Rui Bao, Elmurat Toreniyazov, Hao Ji, Jiangnan Yu, Ximing Xu. Anti-hyperuricemic property of 6-shogaol via self-micro emulsifying drug delivery system in model rats: formulation design, in vitro and in vivo evaluation.
Drug development and industrial pharmacy.
2019 Aug; 45(8):1265-1276. doi:
10.1080/03639045.2019.1594885. [PMID: 30990749] - Ran Li, Rui Bao, Qiu-Xuan Yang, Qi-Long Wang, Michael Adu-Frimpong, Qiu-Yu Wei, Toreniyazov Elmurat, Hao Ji, Jiang-Nan Yu, Xi-Ming Xu. [6]-Shogaol/β-CDs inclusion complex: preparation, characterisation, in vivo pharmacokinetics, and in situ intestinal perfusion study.
Journal of microencapsulation.
2019 Aug; 36(5):500-512. doi:
10.1080/02652048.2019.1649480. [PMID: 31347417] - Kyoung Jin Park, Chung Sub Kim, Zahra Khan, Joonseok Oh, Sun Yeou Kim, Sang Un Choi, Kang Ro Lee. Securinega Alkaloids from the Twigs of Securinega suffruticosa and Their Biological Activities.
Journal of natural products.
2019 05; 82(5):1345-1353. doi:
10.1021/acs.jnatprod.9b00142. [PMID: 31082231] - Mari Morimoto, Mizuki Mitsukawa, Chisato Fujiwara, Yukio Kawamura, Seiji Masuda. Inhibition of mRNA processing activity from ginger-, clove- and cinnamon-extract, and by two ginger constituents, 6-gingerol and 6-shogaol.
Bioscience, biotechnology, and biochemistry.
2019 Mar; 83(3):498-501. doi:
10.1080/09168451.2018.1547107. [PMID: 30426858] - Uddin Md Nazim, Sang-Youel Park. Attenuation of autophagy flux by 6-shogaol sensitizes human liver cancer cells to TRAIL-induced apoptosis via p53 and ROS.
International journal of molecular medicine.
2019 Feb; 43(2):701-708. doi:
10.3892/ijmm.2018.3994. [PMID: 30483736] - Ling-Ling Li, Ying Cui, Xing-Han Guo, Kai Ma, Ping Tian, Jing Feng, Jun-Ming Wang. Pharmacokinetics and Tissue Distribution of Gingerols and Shogaols from Ginger (Zingiber officinale Rosc.) in Rats by UPLC⁻Q-Exactive⁻HRMS.
Molecules (Basel, Switzerland).
2019 Jan; 24(3):. doi:
10.3390/molecules24030512. [PMID: 30708987] - Min-Jung Ko, Hwa-Hyun Nam, Myong-Soo Chung. Conversion of 6-gingerol to 6-shogaol in ginger (Zingiber officinale) pulp and peel during subcritical water extraction.
Food chemistry.
2019 Jan; 270(?):149-155. doi:
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Current pharmaceutical biotechnology.
2019; 20(1):5-16. doi:
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PloS one.
2019; 14(6):e0214893. doi:
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International journal of pharmaceutics.
2018 Oct; 550(1-2):24-34. doi:
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Natural product research.
2018 Sep; 32(18):2139-2146. doi:
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Pakistan journal of pharmaceutical sciences.
2018 Sep; 31(5(Supplementary)):2109-2117. doi:
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Journal of the science of food and agriculture.
2018 Sep; 98(12):4742-4748. doi:
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Journal of agricultural and food chemistry.
2018 Aug; 66(34):9010-9033. doi:
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Molecules (Basel, Switzerland).
2018 07; 23(7):. doi:
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Food research international (Ottawa, Ont.).
2018 Jul; 109(?):472-480. doi:
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Annals of clinical microbiology and antimicrobials.
2018 Apr; 17(1):16. doi:
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Journal of ethnopharmacology.
2018 Mar; 214(?):113-123. doi:
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Food chemistry.
2018 Mar; 243(?):258-268. doi:
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Food & function.
2018 Mar; 9(3):1310-1327. doi:
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Molecules (Basel, Switzerland).
2018 Feb; 23(2):. doi:
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Phytotherapy research : PTR.
2018 Feb; 32(2):340-347. doi:
10.1002/ptr.5982. [PMID: 29168275] - Cheng-Ying Wu, Ming Kong, Wei Zhang, Fang Long, Jing Zhou, Shan-Shan Zhou, Jin-Di Xu, Jun Xu, Song-Lin Li. Impact of sulphur fumigation on the chemistry of ginger.
Food chemistry.
2018 Jan; 239(?):953-963. doi:
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Jan; 97(?):633-641. doi:
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Journal of agricultural and food chemistry.
2017 Nov; 65(44):9618-9625. doi:
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Journal of agricultural and food chemistry.
2017 Sep; 65(38):8356-8362. doi:
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Jul; 91(?):415-424. doi:
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BMC complementary and alternative medicine.
2017 Jun; 17(1):334. doi:
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Journal of natural products.
2017 04; 80(4):1134-1140. doi:
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Journal of food science.
2017 Apr; 82(4):873-881. doi:
10.1111/1750-3841.13661. [PMID: 28231393] - Juan Carlos Romero-Benavides, Ana Lucía Ruano, Ronal Silva-Rivas, Paola Castillo-Veintimilla, Sara Vivanco-Jaramillo, Natalia Bailon-Moscoso. Medicinal plants used as anthelmintics: Ethnomedical, pharmacological, and phytochemical studies.
European journal of medicinal chemistry.
2017 Mar; 129(?):209-217. doi:
10.1016/j.ejmech.2017.02.005. [PMID: 28231520] - Suzuro Hitomi, Kentaro Ono, Kiyoshi Terawaki, Chinami Matsumoto, Keita Mizuno, Kiichiro Yamaguchi, Ryota Imai, Yuji Omiya, Tomohisa Hattori, Yoshio Kase, Kiyotoshi Inenaga. [6]-gingerol and [6]-shogaol, active ingredients of the traditional Japanese medicine hangeshashinto, relief oral ulcerative mucositis-induced pain via action on Na+ channels.
Pharmacological research.
2017 03; 117(?):288-302. doi:
10.1016/j.phrs.2016.12.026. [PMID: 28043879] - Sadineni Varakumar, Kannamangalam Vijayan Umesh, Rekha S Singhal. Enhanced extraction of oleoresin from ginger (Zingiber officinale) rhizome powder using enzyme-assisted three phase partitioning.
Food chemistry.
2017 Feb; 216(?):27-36. doi:
10.1016/j.foodchem.2016.07.180. [PMID: 27596388] - Chien-Kei Wei, Yi-Hong Tsai, Michal Korinek, Pei-Hsuan Hung, Mohamed El-Shazly, Yuan-Bin Cheng, Yang-Chang Wu, Tusty-Jiuan Hsieh, Fang-Rong Chang. 6-Paradol and 6-Shogaol, the Pungent Compounds of Ginger, Promote Glucose Utilization in Adipocytes and Myotubes, and 6-Paradol Reduces Blood Glucose in High-Fat Diet-Fed Mice.
International journal of molecular sciences.
2017 Jan; 18(1):. doi:
10.3390/ijms18010168. [PMID: 28106738] - Xingran Kou, Xingze Li, Md Ramim Tanver Rahman, Minming Yan, Huanhuan Huang, Hongxin Wang, Yihai Su. Efficient dehydration of 6-gingerol to 6-shogaol catalyzed by an acidic ionic liquid under ultrasound irradiation.
Food chemistry.
2017 Jan; 215(?):193-9. doi:
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Journal of natural products.
2016 10; 79(10):2652-2657. doi:
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2016 Aug; 82(?):226-36. doi:
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Food chemistry.
2016 Apr; 197 Pt B(?):1292-300. doi:
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Bioorganic & medicinal chemistry letters.
2016 Apr; 26(8):1877-80. doi:
10.1016/j.bmcl.2016.03.023. [PMID: 26988298] - Suresh Kathiresan, Annamalai Govindhan. [6]-Shogaol, a Novel Chemopreventor in 7,12-Dimethylbenz[a]anthracene-induced Hamster Buccal Pouch Carcinogenesis.
Phytotherapy research : PTR.
2016 Apr; 30(4):646-53. doi:
10.1002/ptr.5574. [PMID: 26840796] - Xu-Xin Hu, Xiao Liu, Yu Chu, Wen-Xing Chen, Ke-Wei Zhang, Hao Wu. [Antiemetic activity of effective extract and bioactive compounds in ginger].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2016 Mar; 41(5):904-909. doi:
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Journal of natural products.
2016 Feb; 79(2):387-94. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Feb; 1011(?):223-32. doi:
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Biological & pharmaceutical bulletin.
2016; 39(7):1107-11. doi:
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Biomedical and environmental sciences : BES.
2015 Nov; 28(11):808-19. doi:
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Food & function.
2015 Aug; 6(8):2813-23. doi:
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BMC complementary and alternative medicine.
2015 Jul; 15(?):258. doi:
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Phytomedicine : international journal of phytotherapy and phytopharmacology.
2015 Jun; 22(6):621-30. doi:
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Journal of natural products.
2015 May; 78(5):1174-8. doi:
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Molecular nutrition & food research.
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