Palmitoylethanolamide (BioDeep_00000002671)
Secondary id: BioDeep_00000408598, BioDeep_00001871347
human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite
代谢物信息卡片
N-(2-hydroxyethyl)hexadecanamide
化学式: C18H37NO2 (299.2824)
中文名称: 棕榈酰乙醇酰胺, 十六酰胺乙醇
谱图信息:
最多检出来源 Homo sapiens(lipidomics) 10.98%
Reviewed
Last reviewed on 2024-10-24.
Cite this Page
Palmitoylethanolamide. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/palmitoylethanolamide (retrieved
2024-12-22) (BioDeep RN: BioDeep_00000002671). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: C(CCCCCCCCCCCCCC)C(=O)NCCO
InChI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)19-16-17-20/h20H,2-17H2,1H3,(H,19,21)
描述信息
N-Palmitoylethanolamide (PEA) is present in the tissues of most mammals. It was initially described as an agonist of the type 2 cannabinoid receptor (CB2), although it is now universally recognized that PEA is in fact incapable of binding to cannabinoid receptors, or at least not to the known receptors. In addition to its anti-inflammatory activity, PEA also produces analgesia, neuroprotection, and possesses anti-epileptic properties. It also reduces gastrointestinal motility and cancer cell proliferation, as well as protecting the vascular endothelium in the ischemic heart. The physiological stimuli that regulate PEA levels in mammalian tissues are largely unknown, however, multiple studies indicate that this lipid accumulates during cellular stress, particularly following tissue injury. For example, PEA increases post-mortem in the pig brain. Similar elevations in PEA levels have been observed in the ischemic brain and PEA is also up-regulated in response to ultraviolet-B irradiation in mouse epidermal cells. Adipose tissue is highly implicated in the systemic secretion of IL-6 and leptin, and human mature adipocytes are able to secrete large quantity of PEA. Human adipose tissue can be subjected to modulation of its inflammatory state by lipopolysaccharide (LPS). LPS strongly inhibits adipose cell leptin release, with PEA acting as a potentiator of this inhibitory effect. These actions are not linked to a reduction in leptin gene transcription. Thus, PEA does not have an anti-inflammatory role in the secretion of IL-6 via NFkappaB at the adipocyte level, but instead seems to act at the heart of the LPS-stimulated pathway, which, independently of NFkappaB, inhibits the secretion of leptin. (PMID: 16884908).
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D063385 - Cannabinoid Receptor Modulators
D018377 - Neurotransmitter Agents > D063385 - Cannabinoid Receptor Modulators > D063386 - Cannabinoid Receptor Agonists
Isolated from soybean lecithin, egg yolk and peanut meal. Palmidrol is found in eggs, pulses, and nuts.
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
Same as: D08328
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Palmitoylethanolamide (Palmidrol) is an active endogenous compound which can used for preventing virus infection of the respiratory tract.
同义名列表
35 个代谢物同义名
Monoethanolamine palmitic acid amide; Palmitinsaeure-beta-hydroxyethylamid; Palmitinsaeure-b-hydroxyethylamid; N-(2-hydroxyethyl)-hexadecanamide; Palmitinsaeure-β-hydroxyethylamid; Monoethanolamine palmitate amide; N-(2-Hydroxyethyl)hexadecanamide; Palmitic acid monoethanolamide; N-(2-Hydroxyethyl)palmitamide; N-hexadecanoyl-ethanolamine; N-Hexadecanoyl ethanolamine; N-(2-Hydroxyethyl)palmitate; Palmitate monoethanolamide; N-Hexadecanoylethanolamine; Hexadecanoyl ethanolamide; N-palmitoyl ethanolamine; N-Hexadecyl-ethanolamine; N-Palmitoylethanolamine; Hydroxyethylpalmitamide; Palmitoyl ethanolamide; Palmitoylethanolamide; Palmitylethanolamide; Anandamide (16:0); Palmitamide mea; Palmdrol prodes; Loramine P 256; Palmitoyl-EA; Palmidrolum; Palmidrol; Impulsin; NAE 16:0; MimyX; PEA; Palmitoylethanolamide; Palmitoylethanolamide
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:71464
- KEGG: C16512
- PubChem: 4671
- HMDB: HMDB0002100
- Metlin: METLIN43210
- DrugBank: DB14043
- ChEMBL: CHEMBL417675
- Wikipedia: Palmitoylethanolamide
- LipidMAPS: LMFA08040013
- foodb: FDB001087
- chemspider: 4509
- CAS: 544-31-0
- PMhub: MS000004410
- PubChem: 49661772
- NIKKAJI: J6.414I
- medchemexpress: HY-20685
- KNApSAcK: 71464
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 3708 - Brassica napus: 10.3389/FNUT.2022.822033
- 9606 - Homo sapiens: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Stefania Nobili, Laura Micheli, Elena Lucarini, Alessandra Toti, Carla Ghelardini, Lorenzo Di Cesare Mannelli. Ultramicronized N-palmitoylethanolamine associated with analgesics: Effects against persistent pain.
Pharmacology & therapeutics.
2024 Jun; 258(?):108649. doi:
10.1016/j.pharmthera.2024.108649. [PMID: 38615798] - Simone Mulè, Giorgia Rosso, Mattia Botta, Arianna Brovero, Sara Ferrari, Rebecca Galla, Claudio Molinari, Francesca Uberti. Design of Mixed Medicinal Plants, Rich in Polyphenols, Vitamins B, and Palmitoylethanolamide-Based Supplement to Help Reduce Nerve Pain: A Preclinical Study.
International journal of molecular sciences.
2024 Apr; 25(9):. doi:
10.3390/ijms25094790. [PMID: 38732008] - Nadia Kim, Brenda Parolin, Derek Renshaw, Sanjoy K Deb, Mohammed Gulrez Zariwala. Formulated Palmitoylethanolamide Supplementation Improves Parameters of Cognitive Function and BDNF Levels in Young, Healthy Adults: A Randomised Cross-Over Trial.
Nutrients.
2024 Feb; 16(4):. doi:
10.3390/nu16040489. [PMID: 38398813] - Amanda Rao, Rachael Skinner, David Briskey. The Efficacy of Palmitoylethanolamide (Levagen+) on the Incidence and Symptoms of Upper Respiratory Tract Infection-A Double Blind, Randomised, Placebo-Controlled Trial.
Nutrients.
2023 Oct; 15(20):. doi:
10.3390/nu15204453. [PMID: 37892528] - Luwen Zhang, Wenjuan Tang, Yinan Ouyang, Miao Zhang, Ruirui Li, Lianping Sun, Chao Liu, Hailing Yu. N-palmitoylethanolamine modulates hippocampal neuroplasticity in rats with stress-induced depressive behavior phenotype.
European journal of pharmacology.
2023 Sep; 957(?):176041. doi:
10.1016/j.ejphar.2023.176041. [PMID: 37673363] - Alessandro Tafuri, Andrea Panunzio, Rita De Mitri, Federico Benetti, Elisa Gaio, Vincenzo Pagliarulo. Micronized Palmitoylethanolamide, Hempseed Oil, and Maritime Pine Bark Dry Extract (Pelvipea®) for Pelvic Pain: An In Vitro Study for Urothelial Inflammation Treatment.
Cells.
2023 Feb; 12(4):. doi:
10.3390/cells12040616. [PMID: 36831284] - Alzbeta Svobodova, Vladimir Vrkoslav, Ingrida Smeringaiova, Katerina Jirsova. Distribution of an analgesic palmitoylethanolamide and other N-acylethanolamines in human placental membranes.
PloS one.
2023; 18(1):e0279863. doi:
10.1371/journal.pone.0279863. [PMID: 36638082] - Duncan Schwaller, Yi Sui, Alain Carvalho, Dominique Collin, Philippe J Mésini. Palmitoylethanolamide gels edible oils.
Food chemistry.
2022 Aug; 386(?):132671. doi:
10.1016/j.foodchem.2022.132671. [PMID: 35334321] - Marta Valenza, Roberta Facchinetti, Luca Steardo, Caterina Scuderi. Palmitoylethanolamide and White Matter Lesions: Evidence for Therapeutic Implications.
Biomolecules.
2022 08; 12(9):. doi:
10.3390/biom12091191. [PMID: 36139030] - Martina Assogna, Francesco Di Lorenzo, Alessandro Martorana, Giacomo Koch. Synaptic Effects of Palmitoylethanolamide in Neurodegenerative Disorders.
Biomolecules.
2022 08; 12(8):. doi:
10.3390/biom12081161. [PMID: 36009055] - Loredana Raciti, Rosaria De Luca, Gianfranco Raciti, Francesca Antonia Arcadi, Rocco Salvatore Calabrò. The Use of Palmitoylethanolamide in the Treatment of Long COVID: A Real-Life Retrospective Cohort Study.
Medical sciences (Basel, Switzerland).
2022 07; 10(3):. doi:
10.3390/medsci10030037. [PMID: 35893119] - Takashi Ozaki, Naganori Kamiyama, Benjawan Saechue, Yasuhiro Soga, Ryo Gotoh, Tatsuya Nakayama, Chiaki Fukuda, Astri Dewayani, Thanyakorn Chalalai, Shimpei Ariki, Sotaro Ozaka, Akira Sonoda, Haruna Hirose, Yoshiko Gendo, Kaori Noguchi, Nozomi Sachi, Shinya Hidano, Keisuke Maeshima, Koro Gotoh, Takayuki Masaki, Koji Ishii, Yoshio Osada, Hirotaka Shibata, Takashi Kobayashi. Comprehensive lipidomics of lupus-prone mice using LC-MS/MS identifies the reduction of palmitoylethanolamide that suppresses TLR9-mediated inflammation.
Genes to cells : devoted to molecular & cellular mechanisms.
2022 Jul; 27(7):493-504. doi:
10.1111/gtc.12944. [PMID: 35485445] - Rossella Fonnesu, Venkata Bala Sai Chaitanya Thunuguntla, Ganesh Kumar Veeramachaneni, Jayakumar Singh Bondili, Veronica La Rocca, Carolina Filipponi, Pietro Giorgio Spezia, Maria Sidoti, Erika Plicanti, Paola Quaranta, Giulia Freer, Mauro Pistello, Michael Lee Mathai, Michele Lai. Palmitoylethanolamide (PEA) Inhibits SARS-CoV-2 Entry by Interacting with S Protein and ACE-2 Receptor.
Viruses.
2022 05; 14(5):. doi:
10.3390/v14051080. [PMID: 35632821] - Eugenia Landolfo, Debora Cutuli, Laura Petrosini, Carlo Caltagirone. Effects of Palmitoylethanolamide on Neurodegenerative Diseases: A Review from Rodents to Humans.
Biomolecules.
2022 05; 12(5):. doi:
10.3390/biom12050667. [PMID: 35625595] - Adriano Lama, Claudio Pirozzi, Ilenia Severi, Maria Grazia Morgese, Martina Senzacqua, Chiara Annunziata, Federica Comella, Filomena Del Piano, Stefania Schiavone, Stefania Petrosino, Maria Pina Mollica, Sabrina Diano, Luigia Trabace, Antonio Calignano, Antonio Giordano, Giuseppina Mattace Raso, Rosaria Meli. Palmitoylethanolamide dampens neuroinflammation and anxiety-like behavior in obese mice.
Brain, behavior, and immunity.
2022 05; 102(?):110-123. doi:
10.1016/j.bbi.2022.02.008. [PMID: 35176443] - Tatsuya Ihara, Hiroshi Shimura, Sachiko Tsuchiya, Mie Kanda, Satoru Kira, Norifumi Sawada, Masayuki Takeda, Takahiko Mitsui, Eiji Shigetomi, Yoichi Shinozaki, Schuichi Koizumi. Effects of fatty acid metabolites on nocturia.
Scientific reports.
2022 02; 12(1):3050. doi:
10.1038/s41598-022-07096-5. [PMID: 35197540] - J Maghfour, H Rietcheck, M D Szeto, C W Rundle, T E Sivesind, R P Dellavalle, P Lio, C A Dunnick, J Fernandez, H Yardley. Tolerability profile of topical cannabidiol and palmitoylethanolamide: a compilation of single-centre randomized evaluator-blinded clinical and in vitro studies in normal skin.
Clinical and experimental dermatology.
2021 Dec; 46(8):1518-1529. doi:
10.1111/ced.14749. [PMID: 34022073] - Paul Clayton, Silma Subah, Ruchitha Venkatesh, Mariko Hill, Nathasha Bogoda. Palmitoylethanolamide: A Potential Alternative to Cannabidiol.
Journal of dietary supplements.
2021 Nov; ?(?):1-26. doi:
10.1080/19390211.2021.2005733. [PMID: 34842030] - Ramona D'Amico, Francesco Monaco, Rosalba Siracusa, Marika Cordaro, Roberta Fusco, Alessio Filippo Peritore, Enrico Gugliandolo, Rosalia Crupi, Salvatore Cuzzocrea, Rosanna Di Paola, Daniela Impellizzeri, Tiziana Genovese. Ultramicronized Palmitoylethanolamide in the Management of Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation.
International journal of molecular sciences.
2021 Oct; 22(21):. doi:
10.3390/ijms222111388. [PMID: 34768820] - Jae In Jung, Hyun Sook Lee, Young Eun Jeon, So Mi Kim, Su Hee Hong, Joo Myung Moon, Cho Young Lim, Yoon Hee Kim, Eun Ji Kim. Anti-inflammatory activity of palmitoylethanolamide ameliorates osteoarthritis induced by monosodium iodoacetate in Sprague-Dawley rats.
Inflammopharmacology.
2021 Oct; 29(5):1475-1486. doi:
10.1007/s10787-021-00870-3. [PMID: 34468900] - Roberto De Icco, Rosaria Greco, Chiara Demartini, Pietro Vergobbi, Annamaria Zanaboni, Elena Tumelero, Angelo Reggiani, Natalia Realini, Grazia Sances, Valentina Grillo, Marta Allena, Cristina Tassorelli. Spinal nociceptive sensitization and plasma palmitoylethanolamide levels during experimentally induced migraine attacks.
Pain.
2021 09; 162(9):2376-2385. doi:
10.1097/j.pain.0000000000002223. [PMID: 33587406] - L D'Ascanio, F Vitelli, C Cingolani, M Maranzano, M J Brenner, A Di Stadio. Randomized clinical trial 'olfactory dysfunction after COVID-19: olfactory rehabilitation therapy vs. intervention treatment with Palmitoylethanolamide and Luteolin': preliminary results.
European review for medical and pharmacological sciences.
2021 06; 25(11):4156-4162. doi:
10.26355/eurrev_202106_26059. [PMID: 34156697] - Luca Roncati, Beatrice Lusenti, Federica Pellati, Lorenzo Corsi. Micronized / ultramicronized palmitoylethanolamide (PEA) as natural neuroprotector against COVID-19 inflammation.
Prostaglandins & other lipid mediators.
2021 06; 154(?):106540. doi:
10.1016/j.prostaglandins.2021.106540. [PMID: 33636368] - Paul Clayton, Mariko Hill, Nathasha Bogoda, Silma Subah, Ruchitha Venkatesh. Palmitoylethanolamide: A Natural Compound for Health Management.
International journal of molecular sciences.
2021 May; 22(10):. doi:
10.3390/ijms22105305. [PMID: 34069940] - Alex Mabou Tagne, Yannick Fotio, Lin Lin, Erica Squire, Faizy Ahmed, Tarif Ibne Rashid, Elnaz Karimian Azari, Daniele Piomelli. Palmitoylethanolamide and hemp oil extract exert synergistic anti-nociceptive effects in mouse models of acute and chronic pain.
Pharmacological research.
2021 05; 167(?):105545. doi:
10.1016/j.phrs.2021.105545. [PMID: 33722712] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Alessia D'Aloia, Laura Molteni, Francesca Gullo, Elena Bresciani, Valentina Artusa, Laura Rizzi, Michela Ceriani, Ramona Meanti, Marzia Lecchi, Silvia Coco, Barbara Costa, Antonio Torsello. Palmitoylethanolamide Modulation of Microglia Activation: Characterization of Mechanisms of Action and Implication for Its Neuroprotective Effects.
International journal of molecular sciences.
2021 Mar; 22(6):. doi:
10.3390/ijms22063054. [PMID: 33802689] - Emiliano Manzo, Aniello Schiano Moriello, Francesco Tinto, Roberta Verde, Marco Allarà, Luciano De Petrocellis, Ester Pagano, Angelo A Izzo, Vincenzo Di Marzo, Stefania Petrosino. A Glucuronic Acid-Palmitoylethanolamide Conjugate (GLUPEA) Is an Innovative Drug Delivery System and a Potential Bioregulator.
Cells.
2021 02; 10(2):. doi:
10.3390/cells10020450. [PMID: 33672574] - Dong-Soon Im. GPR119 and GPR55 as Receptors for Fatty Acid Ethanolamides, Oleoylethanolamide and Palmitoylethanolamide.
International journal of molecular sciences.
2021 Jan; 22(3):. doi:
10.3390/ijms22031034. [PMID: 33494185] - Yannick Fotio, Roberto Ciccocioppo, Daniele Piomelli. N-acylethanolamine acid amidase (NAAA) inhibition decreases the motivation for alcohol in Marchigian Sardinian alcohol-preferring rats.
Psychopharmacology.
2021 Jan; 238(1):249-258. doi:
10.1007/s00213-020-05678-7. [PMID: 33037452] - Alex Y Pai, Cachet Wenziger, Elani Streja, Donovan A Argueta, Nicholas V DiPatrizio, Connie M Rhee, Nosratola D Vaziri, Kamyar Kalantar-Zadeh, Daniele Piomelli, Hamid Moradi. Impact of Circulating N-Acylethanolamine Levels with Clinical and Laboratory End Points in Hemodialysis Patients.
American journal of nephrology.
2021; 52(1):59-68. doi:
10.1159/000513381. [PMID: 33601382] - Stefania Petrosino, Aniello Schiano Moriello. Palmitoylethanolamide: A Nutritional Approach to Keep Neuroinflammation within Physiological Boundaries-A Systematic Review.
International journal of molecular sciences.
2020 Dec; 21(24):. doi:
10.3390/ijms21249526. [PMID: 33333772] - Alessia D'Aloia, Federica Arrigoni, Renata Tisi, Alessandro Palmioli, Michela Ceriani, Valentina Artusa, Cristina Airoldi, Giuseppe Zampella, Barbara Costa, Laura Cipolla. Synthesis, Molecular Modeling and Biological Evaluation of Metabolically Stable Analogues of the Endogenous Fatty Acid Amide Palmitoylethanolamide.
International journal of molecular sciences.
2020 Nov; 21(23):. doi:
10.3390/ijms21239074. [PMID: 33260658] - Aysha Karim Kiani, Giacinto Abele Donato Miggiano, Barbara Aquilanti, Valeria Velluti, Giuseppina Matera, Lucilla Gagliardi, Matteo Bertelli. Food supplements based on palmitoylethanolamide plus hydroxytyrosol from olive tree or Bacopa monnieri extracts for neurological diseases.
Acta bio-medica : Atenei Parmensis.
2020 11; 91(13-S):e2020007. doi:
10.23750/abm.v91i13-s.10582. [PMID: 33170159] - Annagrazia Adornetto, Laura Rombolà, Luigi Antonio Morrone, Carlo Nucci, Maria Tiziana Corasaniti, Giacinto Bagetta, Rossella Russo. Natural Products: Evidence for Neuroprotection to Be Exploited in Glaucoma.
Nutrients.
2020 Oct; 12(10):. doi:
10.3390/nu12103158. [PMID: 33081127] - Antonio Gigante, Alberto Aquili, Luca Farinelli, Alessandro Caraffa, Gianpaolo Ronconi, Carla Enrica Gallenga, Giulia Tetè, Spyros K Kritas, Pio Conti. Sodium chromo-glycate and palmitoylethanolamide: A possible strategy to treat mast cell-induced lung inflammation in COVID-19.
Medical hypotheses.
2020 Oct; 143(?):109856. doi:
10.1016/j.mehy.2020.109856. [PMID: 32460208] - Sarah Beggiato, Tommaso Cassano, Luca Ferraro, Maria C Tomasini. Astrocytic palmitoylethanolamide pre-exposure exerts neuroprotective effects in astrocyte-neuron co-cultures from a triple transgenic mouse model of Alzheimer's disease.
Life sciences.
2020 Sep; 257(?):118037. doi:
10.1016/j.lfs.2020.118037. [PMID: 32622942] - E Appiah-Kusi, R Wilson, M Colizzi, E Foglia, E Klamerus, A Caldwell, M G Bossong, P McGuire, S Bhattacharyya. Childhood trauma and being at-risk for psychosis are associated with higher peripheral endocannabinoids.
Psychological medicine.
2020 08; 50(11):1862-1871. doi:
10.1017/s0033291719001946. [PMID: 31422779] - Ramona D'Amico, Daniela Impellizzeri, Salvatore Cuzzocrea, Rosanna Di Paola. ALIAmides Update: Palmitoylethanolamide and Its Formulations on Management of Peripheral Neuropathic Pain.
International journal of molecular sciences.
2020 Jul; 21(15):. doi:
10.3390/ijms21155330. [PMID: 32727084] - Daniele Piomelli, Laura Scalvini, Yannick Fotio, Alessio Lodola, Gilberto Spadoni, Giorgio Tarzia, Marco Mor. N-Acylethanolamine Acid Amidase (NAAA): Structure, Function, and Inhibition.
Journal of medicinal chemistry.
2020 07; 63(14):7475-7490. doi:
10.1021/acs.jmedchem.0c00191. [PMID: 32191459] - Niclas Stensson, Björn Gerdle, Malin Ernberg, Kaisa Mannerkorpi, Eva Kosek, Bijar Ghafouri. Increased Anandamide and Decreased Pain and Depression after Exercise in Fibromyalgia.
Medicine and science in sports and exercise.
2020 07; 52(7):1617-1628. doi:
10.1249/mss.0000000000002293. [PMID: 32168104] - Lea Tischmann, Mathijs Drummen, Peter J Joris, Blandine Gatta-Cherifi, Anne Raben, Mikael Fogelholm, Isabelle Matias, Daniela Cota, Ronald P Mensink, Margriet S Westerterp-Plantenga, Tanja C Adam. Effects of a High-Protein Diet on Cardiometabolic Health, Vascular Function, and Endocannabinoids-A PREVIEW Study.
Nutrients.
2020 May; 12(5):. doi:
10.3390/nu12051512. [PMID: 32455987] - Dorian Forte, Flaminia Fanelli, Marco Mezzullo, Martina Barone, Giulia Corradi, Giuseppe Auteri, Daniela Bartoletti, Marina Martello, Emanuela Ottaviani, Carolina Terragna, Antonio Curti, Uberto Pagotto, Francesca Palandri, Michele Cavo, Lucia Catani. Disease-Specific Derangement of Circulating Endocannabinoids and N-Acylethanolamines in Myeloproliferative Neoplasms.
International journal of molecular sciences.
2020 May; 21(9):. doi:
10.3390/ijms21093399. [PMID: 32403407] - Wenhui Jin, Longhe Yang, Zhiwei Yi, Hua Fang, Weizhu Chen, Zhuan Hong, Yiping Zhang, Guangya Zhang, Long Li. Anti-Inflammatory Effects of Fucoxanthinol in LPS-Induced RAW264.7 Cells through the NAAA-PEA Pathway.
Marine drugs.
2020 Apr; 18(4):. doi:
10.3390/md18040222. [PMID: 32326173] - Alistair Mallard, David Briskey, Andrew Richards, Dean Mills, Amanda Rao. The Effect of Orally Dosed Levagen+™ (palmitoylethanolamide) on Exercise Recovery in Healthy Males-A Double-Blind, Randomized, Placebo-Controlled Study.
Nutrients.
2020 Feb; 12(3):. doi:
10.3390/nu12030596. [PMID: 32106527] - Gianfranca Carta, Elisabetta Murru, Romina Vargiu, Maria Collu, Manolo Carta, Sebastiano Banni, Roberto Stancampiano. Essential fatty acids deficient diet modulates N-Acylethanolamide profile in rat's tissues.
Prostaglandins, leukotrienes, and essential fatty acids.
2020 02; 153(?):102053. doi:
10.1016/j.plefa.2020.102053. [PMID: 31978675] - Chiara Annunziata, Adriano Lama, Claudio Pirozzi, Gina Cavaliere, Giovanna Trinchese, Francesca Di Guida, Allegra Nitrato Izzo, Fabiano Cimmino, Orlando Paciello, Davide De Biase, Elisabetta Murru, Sebastiano Banni, Antonio Calignano, Maria Pina Mollica, Giuseppina Mattace Raso, Rosaria Meli. Palmitoylethanolamide counteracts hepatic metabolic inflexibility modulating mitochondrial function and efficiency in diet-induced obese mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2020 01; 34(1):350-364. doi:
10.1096/fj.201901510rr. [PMID: 31914699] - Bruno A Marichal-Cancino, Abimael González-Hernández, Antoinette MaassenVanDenBrink, Eduardo Ramírez-San Juan, Carlos M Villalón. Potential Mechanisms Involved in Palmitoylethanolamide-Induced Vasodepressor Effects in Rats.
Journal of vascular research.
2020; 57(3):152-163. doi:
10.1159/000506158. [PMID: 32248195] - Miguel Gómez-Boronat, Esther Isorna, Marta Conde-Sieira, María J Delgado, José L Soengas, Nuria de Pedro. First evidence on the role of palmitoylethanolamide in energy homeostasis in fish.
Hormones and behavior.
2020 01; 117(?):104609. doi:
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Psychoneuroendocrinology.
2020 01; 111(?):104471. doi:
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Journal of neuroinflammation.
2019 Dec; 16(1):274. doi:
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International journal of cosmetic science.
2019 Dec; 41(6):534-547. doi:
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European journal of obstetrics, gynecology, and reproductive biology.
2019 Dec; 243(?):1-6. doi:
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Talanta.
2019 Nov; 204(?):386-394. doi:
10.1016/j.talanta.2019.06.004. [PMID: 31357310] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Silvia Pieralice, Riccardo Vari, Alessandra Minutolo, Anna Rita Maurizi, Elvira Fioriti, Nicola Napoli, Paolo Pozzilli, Silvia Manfrini, Ernesto Maddaloni. Biomarkers of response to alpha-lipoic acid ± palmitoiletanolamide treatment in patients with diabetes and symptoms of peripheral neuropathy.
Endocrine.
2019 11; 66(2):178-184. doi:
10.1007/s12020-019-01917-w. [PMID: 30949911] - Daniela Impellizzeri, Alessio Filippo Peritore, Marika Cordaro, Enrico Gugliandolo, Rosalba Siracusa, Rosalia Crupi, Ramona D'Amico, Roberta Fusco, Maurizio Evangelista, Salvatore Cuzzocrea, Rosanna Di Paola. The neuroprotective effects of micronized PEA (PEA-m) formulation on diabetic peripheral neuropathy in mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2019 10; 33(10):11364-11380. doi:
10.1096/fj.201900538r. [PMID: 31344333] - Jacob D Meyer, Kevin M Crombie, Dane B Cook, Cecilia J Hillard, Kelli F Koltyn. Serum Endocannabinoid and Mood Changes after Exercise in Major Depressive Disorder.
Medicine and science in sports and exercise.
2019 09; 51(9):1909-1917. doi:
10.1249/mss.0000000000002006. [PMID: 30973483] - Dagmar Koethe, Franziska Pahlisch, Martin Hellmich, Cathrin Rohleder, Juliane K Mueller, Andreas Meyer-Lindenberg, E Fuller Torrey, Daniele Piomelli, F Markus Leweke. Familial abnormalities of endocannabinoid signaling in schizophrenia.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.
2019 02; 20(2):117-125. doi:
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Brain, behavior, and immunity.
2018 11; 74(?):166-175. doi:
10.1016/j.bbi.2018.09.003. [PMID: 30193877] - María Antón, Alicia Rodríguez-González, Inmaculada Concepción Rodríguez-Rojo, Antoni Pastor, Ángeles Correas, Antonia Serrano, Antonio Ballesta, Francisco Alén, Raquel Gómez de Heras, Rafael de la Torre, Fernando Rodríguez de Fonseca, Laura Orio. Increased plasma oleoylethanolamide and palmitoleoylethanolamide levels correlate with inflammatory changes in alcohol binge drinkers: the case of HMGB1 in women.
Addiction biology.
2018 11; 23(6):1242-1250. doi:
10.1111/adb.12580. [PMID: 29178411] - Rosalia Crupi, Daniela Impellizzeri, Marika Cordaro, Rosalba Siracusa, Giovanna Casili, Maurizio Evangelista, Salvatore Cuzzocrea. N-palmitoylethanolamide Prevents Parkinsonian Phenotypes in Aged Mice.
Molecular neurobiology.
2018 Nov; 55(11):8455-8472. doi:
10.1007/s12035-018-0959-2. [PMID: 29552727] - Alexei Gorelik, Ahmad Gebai, Katalin Illes, Daniele Piomelli, Bhushan Nagar. Molecular mechanism of activation of the immunoregulatory amidase NAAA.
Proceedings of the National Academy of Sciences of the United States of America.
2018 10; 115(43):E10032-E10040. doi:
10.1073/pnas.1811759115. [PMID: 30301806] - Mariana I Holubiec, Juan I Romero, Juan Suárez, Manuel Portavella, Emilio Fernández-Espejo, Eduardo Blanco, Pablo Galeano, Fernando Rodríguez de Fonseca. Palmitoylethanolamide prevents neuroinflammation, reduces astrogliosis and preserves recognition and spatial memory following induction of neonatal anoxia-ischemia.
Psychopharmacology.
2018 Oct; 235(10):2929-2945. doi:
10.1007/s00213-018-4982-9. [PMID: 30058012] - Valerio Chiurchiù, Alessandro Leuti, Reem Smoum, Raphael Mechoulam, Mauro Maccarrone. Bioactive lipids ALIAmides differentially modulate inflammatory responses of distinct subsets of primary human T lymphocytes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2018 10; 32(10):5716-5723. doi:
10.1096/fj.201800107r. [PMID: 29879374] - Lisa E Flannery, Rebecca J Henry, Daniel M Kerr, David P Finn, Michelle Roche. FAAH, but not MAGL, inhibition modulates acute TLR3-induced neuroimmune signaling in the rat, independent of sex.
Journal of neuroscience research.
2018 06; 96(6):989-1001. doi:
10.1002/jnr.24120. [PMID: 28726298] - Deeptej Singh, Juliya Fisher, Devorah Shagalov, Aakaash Varma, Daniel M Siegel. Dangerous plants in dermatology: Legal and controlled.
Clinics in dermatology.
2018 May; 36(3):399-419. doi:
10.1016/j.clindermatol.2018.03.013. [PMID: 29908582] - Emma Zambrana-Infantes, Cristina Rosell Del Valle, David Ladrón de Guevara-Miranda, Pablo Galeano, Estela Castilla-Ortega, Fernando Rodríguez De Fonseca, Eduardo Blanco, Luis Javier Santín. Palmitoylethanolamide attenuates cocaine-induced behavioral sensitization and conditioned place preference in mice.
Pharmacology, biochemistry, and behavior.
2018 03; 166(?):1-12. doi:
10.1016/j.pbb.2018.01.002. [PMID: 29337083] - Ev Christin Heide, Laura Bindila, Julia Maria Post, Dörthe Malzahn, Beat Lutz, Jana Seele, Roland Nau, Sandra Ribes. Prophylactic Palmitoylethanolamide Prolongs Survival and Decreases Detrimental Inflammation in Aged Mice With Bacterial Meningitis.
Frontiers in immunology.
2018; 9(?):2671. doi:
10.3389/fimmu.2018.02671. [PMID: 30505308] - Sarah Beggiato, Andrea Celeste Borelli, Luca Ferraro, Sergio Tanganelli, Tiziana Antonelli, Maria Cristina Tomasini. Palmitoylethanolamide Blunts Amyloid-β42-Induced Astrocyte Activation and Improves Neuronal Survival in Primary Mouse Cortical Astrocyte-Neuron Co-Cultures.
Journal of Alzheimer's disease : JAD.
2018; 61(1):389-399. doi:
10.3233/jad-170699. [PMID: 29154284] - Dulce E Alarcón-Yaquetto, Lidia Caballero, Gustavo F Gonzales. Association Between Plasma N-Acylethanolamides and High Hemoglobin Concentration in Southern Peruvian Highlanders.
High altitude medicine & biology.
2017 12; 18(4):322-329. doi:
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Scandinavian journal of gastroenterology.
2017 Oct; 52(10):1133-1139. doi:
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Addiction biology.
2017 Sep; 22(5):1366-1377. doi:
10.1111/adb.12408. [PMID: 27212249] - Niclas Stensson, Bijar Ghafouri, Björn Gerdle, Nazdar Ghafouri. Alterations of anti-inflammatory lipids in plasma from women with chronic widespread pain - a case control study.
Lipids in health and disease.
2017 Jun; 16(1):112. doi:
10.1186/s12944-017-0505-7. [PMID: 28606089] - Stefania Petrosino, Vincenzo Di Marzo. The pharmacology of palmitoylethanolamide and first data on the therapeutic efficacy of some of its new formulations.
British journal of pharmacology.
2017 06; 174(11):1349-1365. doi:
10.1111/bph.13580. [PMID: 27539936] - Bruno Giammusso, Rosaria Di Mauro, Renato Bernardini. The efficacy of an association of palmitoylethanolamide and alpha-lipoic acid in patients with chronic prostatitis/chronic pelvic pain syndrome: A randomized clinical trial.
Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica.
2017 Mar; 89(1):17-21. doi:
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Scientific reports.
2017 03; 7(1):375. doi:
10.1038/s41598-017-00342-1. [PMID: 28336953] - Alessandra Quercioli, Federico Carbone, Aldo Bonaventura, Luca Liberale, Zoltan Pataky, Aurélien Thomas, Sébastien Lenglet, Estelle Lauer, Alain Golay, Franco Dallegri, Vincenzo Di Marzo, Thomas H Schindler, Fabrizio Montecucco. Plasma palmitoylethanolamide (PEA) as a potential biomarker for impaired coronary function.
International journal of cardiology.
2017 Mar; 231(?):1-5. doi:
10.1016/j.ijcard.2016.12.023. [PMID: 27989579] - Marina Quartu, Laura Poddighe, Tiziana Melis, Maria Pina Serra, Marianna Boi, Sara Lisai, Gianfranca Carta, Elisabetta Murru, Laura Muredda, Maria Collu, Sebastiano Banni. Involvement of the endocannabinoid system in the physiological response to transient common carotid artery occlusion and reperfusion.
Lipids in health and disease.
2017 Jan; 16(1):14. doi:
10.1186/s12944-016-0389-y. [PMID: 28103941] - Bright N Okine, Manish K Madasu, Fiona McGowan, Charles Prendergast, Jessica C Gaspar, Brendan Harhen, Michelle Roche, David P Finn. N-palmitoylethanolamide in the anterior cingulate cortex attenuates inflammatory pain behaviour indirectly via a CB1 receptor-mediated mechanism.
Pain.
2016 12; 157(12):2687-2696. doi:
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Biochimica et biophysica acta.
2016 12; 1861(12 Pt A):1881-1892. doi:
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European journal of pharmacology.
2016 Nov; 791(?):523-534. doi:
10.1016/j.ejphar.2016.09.029. [PMID: 27663280] - Marika Cordaro, Daniela Impellizzeri, Enrico Gugliandolo, Rosalba Siracusa, Rosalia Crupi, Emanuela Esposito, Salvatore Cuzzocrea. Adelmidrol, a Palmitoylethanolamide Analogue, as a New Pharmacological Treatment for the Management of Inflammatory Bowel Disease.
Molecular pharmacology.
2016 Nov; 90(5):549-561. doi:
10.1124/mol.116.105668. [PMID: 27625036] - Giulia Donvito, Jenny L Wilkerson, M Imad Damaj, Aron H Lichtman. Palmitoylethanolamide Reverses Paclitaxel-Induced Allodynia in Mice.
The Journal of pharmacology and experimental therapeutics.
2016 Nov; 359(2):310-318. doi:
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Angewandte Chemie (International ed. in English).
2016 09; 55(37):11193-11197. doi:
10.1002/anie.201603746. [PMID: 27404798] - T Venkatesan, Y Zadvornova, H Raff, C J Hillard. Endocannabinoid-related lipids are increased during an episode of cyclic vomiting syndrome.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.
2016 Sep; 28(9):1409-18. doi:
10.1111/nmo.12843. [PMID: 27098832] - Ana Maria Sanchez, Raffaella Cioffi, Paola Viganò, Massimo Candiani, Roberta Verde, Fabiana Piscitelli, Vincenzo Di Marzo, Elisabetta Garavaglia, Paola Panina-Bordignon. Elevated Systemic Levels of Endocannabinoids and Related Mediators Across the Menstrual Cycle in Women With Endometriosis.
Reproductive sciences (Thousand Oaks, Calif.).
2016 08; 23(8):1071-9. doi:
10.1177/1933719116630414. [PMID: 26887427] - Christopher A Mitchell, Michael Donaldson, Simona Francese, Malcolm R Clench. MALDI MSI analysis of lipid changes in living skin equivalents in response to emollient creams containing palmitoylethanolamide.
Methods (San Diego, Calif.).
2016 07; 104(?):93-100. doi:
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European journal of nutrition.
2016 Jun; 55(4):1799-805. doi:
10.1007/s00394-016-1153-9. [PMID: 26759262] - Diana Tronino, Alessia Offerta, Carmine Ostacolo, Roberto Russo, Carmen De Caro, Antonio Calignano, Carmelo Puglia, Paolo Blasi. Nanoparticles prolong N-palmitoylethanolamide anti-inflammatory and analgesic effects in vivo.
Colloids and surfaces. B, Biointerfaces.
2016 May; 141(?):311-317. doi:
10.1016/j.colsurfb.2016.01.058. [PMID: 26866893] - Nicola S Orefice, Mireille Alhouayek, Antonio Carotenuto, Silvana Montella, Franscesco Barbato, Albert Comelli, Antonio Calignano, Giulio G Muccioli, Giuseppe Orefice. Oral Palmitoylethanolamide Treatment Is Associated with Reduced Cutaneous Adverse Effects of Interferon-β1a and Circulating Proinflammatory Cytokines in Relapsing-Remitting Multiple Sclerosis.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics.
2016 Apr; 13(2):428-38. doi:
10.1007/s13311-016-0420-z. [PMID: 26857391] - Stefania Petrosino, Aniello Schiano Moriello, Santiago Cerrato, Mariella Fusco, Anna Puigdemont, Luciano De Petrocellis, Vincenzo Di Marzo. The anti-inflammatory mediator palmitoylethanolamide enhances the levels of 2-arachidonoyl-glycerol and potentiates its actions at TRPV1 cation channels.
British journal of pharmacology.
2016 Apr; 173(7):1154-62. doi:
10.1111/bph.13084. [PMID: 25598150] - Carlo Caltagirone, Carlo Cisari, Carlo Schievano, Rosanna Di Paola, Marika Cordaro, Giuseppe Bruschetta, Emanuela Esposito, Salvatore Cuzzocrea. Co-ultramicronized Palmitoylethanolamide/Luteolin in the Treatment of Cerebral Ischemia: from Rodent to Man.
Translational stroke research.
2016 Feb; 7(1):54-69. doi:
10.1007/s12975-015-0440-8. [PMID: 26706245] - Antonella Paladini, Mariella Fusco, Teresa Cenacchi, Carlo Schievano, Alba Piroli, Giustino Varrassi. Palmitoylethanolamide, a Special Food for Medical Purposes, in the Treatment of Chronic Pain: A Pooled Data Meta-analysis.
Pain physician.
2016 Feb; 19(2):11-24. doi:
10.36076/ppj/2016.19.11. [PMID: 26815246] - M Cordaro, D Impellizzeri, G Bruschetta, R Siracusa, R Crupi, R Di Paola, E Esposito, S Cuzzocrea. A novel protective formulation of Palmitoylethanolamide in experimental model of contrast agent induced nephropathy.
Toxicology letters.
2016 Jan; 240(1):10-21. doi:
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Veterinary journal (London, England : 1997).
2016 Jan; 207(?):85-91. doi:
10.1016/j.tvjl.2015.10.060. [PMID: 26639824] - Irene Paterniti, Rosanna Di Paola, Michela Campolo, Rosalba Siracusa, Marika Cordaro, Giuseppe Bruschetta, Gemma Tremolada, Anna Maestroni, Francesco Bandello, Emanuela Esposito, Gianpaolo Zerbini, Salvatore Cuzzocrea. Palmitoylethanolamide treatment reduces retinal inflammation in streptozotocin-induced diabetic rats.
European journal of pharmacology.
2015 Dec; 769(?):313-23. doi:
10.1016/j.ejphar.2015.11.035. [PMID: 26607470] - Chiara Noli, M Federica Della Valle, Alda Miolo, Cristina Medori, Carlo Schievano. Efficacy of ultra-micronized palmitoylethanolamide in canine atopic dermatitis: an open-label multi-centre study.
Veterinary dermatology.
2015 Dec; 26(6):432-40, e101. doi:
10.1111/vde.12250. [PMID: 26283633] - Massimo Barbierato, Laura Facci, Carla Marinelli, Morena Zusso, Carla Argentini, Stephen D Skaper, Pietro Giusti. Co-ultramicronized Palmitoylethanolamide/Luteolin Promotes the Maturation of Oligodendrocyte Precursor Cells.
Scientific reports.
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