Palmitoylethanolamide (BioDeep_00000002671)

 

Secondary id: BioDeep_00000408598, BioDeep_00001871347

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


N-(2-hydroxyethyl)hexadecanamide

化学式: C18H37NO2 (299.2824142)
中文名称: 十六酰胺乙醇, 棕榈酰乙醇酰胺
谱图信息: 最多检出来源 Homo sapiens(lipidomics) 0.44%

Reviewed

Last reviewed on 2024-10-24.

Cite this Page

Palmitoylethanolamide. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/palmitoylethanolamide (retrieved 2024-11-03) (BioDeep RN: BioDeep_00000002671). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(CCCCCCCCCCCCCC)C(=O)NCCO
InChI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)19-16-17-20/h20H,2-17H2,1H3,(H,19,21)

描述信息

N-Palmitoylethanolamide (PEA) is present in the tissues of most mammals. It was initially described as an agonist of the type 2 cannabinoid receptor (CB2), although it is now universally recognized that PEA is in fact incapable of binding to cannabinoid receptors, or at least not to the known receptors. In addition to its anti-inflammatory activity, PEA also produces analgesia, neuroprotection, and possesses anti-epileptic properties. It also reduces gastrointestinal motility and cancer cell proliferation, as well as protecting the vascular endothelium in the ischemic heart. The physiological stimuli that regulate PEA levels in mammalian tissues are largely unknown, however, multiple studies indicate that this lipid accumulates during cellular stress, particularly following tissue injury. For example, PEA increases post-mortem in the pig brain. Similar elevations in PEA levels have been observed in the ischemic brain and PEA is also up-regulated in response to ultraviolet-B irradiation in mouse epidermal cells. Adipose tissue is highly implicated in the systemic secretion of IL-6 and leptin, and human mature adipocytes are able to secrete large quantity of PEA. Human adipose tissue can be subjected to modulation of its inflammatory state by lipopolysaccharide (LPS). LPS strongly inhibits adipose cell leptin release, with PEA acting as a potentiator of this inhibitory effect. These actions are not linked to a reduction in leptin gene transcription. Thus, PEA does not have an anti-inflammatory role in the secretion of IL-6 via NFkappaB at the adipocyte level, but instead seems to act at the heart of the LPS-stimulated pathway, which, independently of NFkappaB, inhibits the secretion of leptin. (PMID: 16884908).
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D063385 - Cannabinoid Receptor Modulators
D018377 - Neurotransmitter Agents > D063385 - Cannabinoid Receptor Modulators > D063386 - Cannabinoid Receptor Agonists
Isolated from soybean lecithin, egg yolk and peanut meal. Palmidrol is found in eggs, pulses, and nuts.
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
Same as: D08328
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Palmitoylethanolamide (Palmidrol) is an active endogenous compound which can used for preventing virus infection of the respiratory tract.

同义名列表

34 个代谢物同义名

Monoethanolamine palmitic acid amide; Palmitinsaeure-beta-hydroxyethylamid; Palmitinsaeure-b-hydroxyethylamid; N-(2-hydroxyethyl)-hexadecanamide; Palmitinsaeure-β-hydroxyethylamid; Monoethanolamine palmitate amide; N-(2-Hydroxyethyl)hexadecanamide; Palmitic acid monoethanolamide; N-(2-Hydroxyethyl)palmitamide; N-hexadecanoyl-ethanolamine; N-Hexadecanoyl ethanolamine; N-(2-Hydroxyethyl)palmitate; Palmitate monoethanolamide; N-Hexadecanoylethanolamine; Hexadecanoyl ethanolamide; N-palmitoyl ethanolamine; N-Hexadecyl-ethanolamine; N-Palmitoylethanolamine; Hydroxyethylpalmitamide; Palmitoyl ethanolamide; Palmitoylethanolamide; Palmitylethanolamide; Anandamide (16:0); Palmitamide mea; Palmdrol prodes; Loramine P 256; Palmitoyl-EA; Palmidrolum; Palmidrol; Impulsin; NAE 16:0; MimyX; PEA; Palmitoylethanolamide



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Stefania Nobili, Laura Micheli, Elena Lucarini, Alessandra Toti, Carla Ghelardini, Lorenzo Di Cesare Mannelli. Ultramicronized N-palmitoylethanolamine associated with analgesics: Effects against persistent pain. Pharmacology & therapeutics. 2024 Jun; 258(?):108649. doi: 10.1016/j.pharmthera.2024.108649. [PMID: 38615798]
  • Simone Mulè, Giorgia Rosso, Mattia Botta, Arianna Brovero, Sara Ferrari, Rebecca Galla, Claudio Molinari, Francesca Uberti. Design of Mixed Medicinal Plants, Rich in Polyphenols, Vitamins B, and Palmitoylethanolamide-Based Supplement to Help Reduce Nerve Pain: A Preclinical Study. International journal of molecular sciences. 2024 Apr; 25(9):. doi: 10.3390/ijms25094790. [PMID: 38732008]
  • Nadia Kim, Brenda Parolin, Derek Renshaw, Sanjoy K Deb, Mohammed Gulrez Zariwala. Formulated Palmitoylethanolamide Supplementation Improves Parameters of Cognitive Function and BDNF Levels in Young, Healthy Adults: A Randomised Cross-Over Trial. Nutrients. 2024 Feb; 16(4):. doi: 10.3390/nu16040489. [PMID: 38398813]
  • Amanda Rao, Rachael Skinner, David Briskey. The Efficacy of Palmitoylethanolamide (Levagen+) on the Incidence and Symptoms of Upper Respiratory Tract Infection-A Double Blind, Randomised, Placebo-Controlled Trial. Nutrients. 2023 Oct; 15(20):. doi: 10.3390/nu15204453. [PMID: 37892528]
  • Luwen Zhang, Wenjuan Tang, Yinan Ouyang, Miao Zhang, Ruirui Li, Lianping Sun, Chao Liu, Hailing Yu. N-palmitoylethanolamine modulates hippocampal neuroplasticity in rats with stress-induced depressive behavior phenotype. European journal of pharmacology. 2023 Sep; 957(?):176041. doi: 10.1016/j.ejphar.2023.176041. [PMID: 37673363]
  • Alessandro Tafuri, Andrea Panunzio, Rita De Mitri, Federico Benetti, Elisa Gaio, Vincenzo Pagliarulo. Micronized Palmitoylethanolamide, Hempseed Oil, and Maritime Pine Bark Dry Extract (Pelvipea®) for Pelvic Pain: An In Vitro Study for Urothelial Inflammation Treatment. Cells. 2023 Feb; 12(4):. doi: 10.3390/cells12040616. [PMID: 36831284]
  • Alzbeta Svobodova, Vladimir Vrkoslav, Ingrida Smeringaiova, Katerina Jirsova. Distribution of an analgesic palmitoylethanolamide and other N-acylethanolamines in human placental membranes. PloS one. 2023; 18(1):e0279863. doi: 10.1371/journal.pone.0279863. [PMID: 36638082]
  • Duncan Schwaller, Yi Sui, Alain Carvalho, Dominique Collin, Philippe J Mésini. Palmitoylethanolamide gels edible oils. Food chemistry. 2022 Aug; 386(?):132671. doi: 10.1016/j.foodchem.2022.132671. [PMID: 35334321]
  • Marta Valenza, Roberta Facchinetti, Luca Steardo, Caterina Scuderi. Palmitoylethanolamide and White Matter Lesions: Evidence for Therapeutic Implications. Biomolecules. 2022 08; 12(9):. doi: 10.3390/biom12091191. [PMID: 36139030]
  • Martina Assogna, Francesco Di Lorenzo, Alessandro Martorana, Giacomo Koch. Synaptic Effects of Palmitoylethanolamide in Neurodegenerative Disorders. Biomolecules. 2022 08; 12(8):. doi: 10.3390/biom12081161. [PMID: 36009055]
  • Loredana Raciti, Rosaria De Luca, Gianfranco Raciti, Francesca Antonia Arcadi, Rocco Salvatore Calabrò. The Use of Palmitoylethanolamide in the Treatment of Long COVID: A Real-Life Retrospective Cohort Study. Medical sciences (Basel, Switzerland). 2022 07; 10(3):. doi: 10.3390/medsci10030037. [PMID: 35893119]
  • Takashi Ozaki, Naganori Kamiyama, Benjawan Saechue, Yasuhiro Soga, Ryo Gotoh, Tatsuya Nakayama, Chiaki Fukuda, Astri Dewayani, Thanyakorn Chalalai, Shimpei Ariki, Sotaro Ozaka, Akira Sonoda, Haruna Hirose, Yoshiko Gendo, Kaori Noguchi, Nozomi Sachi, Shinya Hidano, Keisuke Maeshima, Koro Gotoh, Takayuki Masaki, Koji Ishii, Yoshio Osada, Hirotaka Shibata, Takashi Kobayashi. Comprehensive lipidomics of lupus-prone mice using LC-MS/MS identifies the reduction of palmitoylethanolamide that suppresses TLR9-mediated inflammation. Genes to cells : devoted to molecular & cellular mechanisms. 2022 Jul; 27(7):493-504. doi: 10.1111/gtc.12944. [PMID: 35485445]
  • Rossella Fonnesu, Venkata Bala Sai Chaitanya Thunuguntla, Ganesh Kumar Veeramachaneni, Jayakumar Singh Bondili, Veronica La Rocca, Carolina Filipponi, Pietro Giorgio Spezia, Maria Sidoti, Erika Plicanti, Paola Quaranta, Giulia Freer, Mauro Pistello, Michael Lee Mathai, Michele Lai. Palmitoylethanolamide (PEA) Inhibits SARS-CoV-2 Entry by Interacting with S Protein and ACE-2 Receptor. Viruses. 2022 05; 14(5):. doi: 10.3390/v14051080. [PMID: 35632821]
  • Eugenia Landolfo, Debora Cutuli, Laura Petrosini, Carlo Caltagirone. Effects of Palmitoylethanolamide on Neurodegenerative Diseases: A Review from Rodents to Humans. Biomolecules. 2022 05; 12(5):. doi: 10.3390/biom12050667. [PMID: 35625595]
  • Adriano Lama, Claudio Pirozzi, Ilenia Severi, Maria Grazia Morgese, Martina Senzacqua, Chiara Annunziata, Federica Comella, Filomena Del Piano, Stefania Schiavone, Stefania Petrosino, Maria Pina Mollica, Sabrina Diano, Luigia Trabace, Antonio Calignano, Antonio Giordano, Giuseppina Mattace Raso, Rosaria Meli. Palmitoylethanolamide dampens neuroinflammation and anxiety-like behavior in obese mice. Brain, behavior, and immunity. 2022 05; 102(?):110-123. doi: 10.1016/j.bbi.2022.02.008. [PMID: 35176443]
  • Tatsuya Ihara, Hiroshi Shimura, Sachiko Tsuchiya, Mie Kanda, Satoru Kira, Norifumi Sawada, Masayuki Takeda, Takahiko Mitsui, Eiji Shigetomi, Yoichi Shinozaki, Schuichi Koizumi. Effects of fatty acid metabolites on nocturia. Scientific reports. 2022 02; 12(1):3050. doi: 10.1038/s41598-022-07096-5. [PMID: 35197540]
  • J Maghfour, H Rietcheck, M D Szeto, C W Rundle, T E Sivesind, R P Dellavalle, P Lio, C A Dunnick, J Fernandez, H Yardley. Tolerability profile of topical cannabidiol and palmitoylethanolamide: a compilation of single-centre randomized evaluator-blinded clinical and in vitro studies in normal skin. Clinical and experimental dermatology. 2021 Dec; 46(8):1518-1529. doi: 10.1111/ced.14749. [PMID: 34022073]
  • Paul Clayton, Silma Subah, Ruchitha Venkatesh, Mariko Hill, Nathasha Bogoda. Palmitoylethanolamide: A Potential Alternative to Cannabidiol. Journal of dietary supplements. 2021 Nov; ?(?):1-26. doi: 10.1080/19390211.2021.2005733. [PMID: 34842030]
  • Ramona D'Amico, Francesco Monaco, Rosalba Siracusa, Marika Cordaro, Roberta Fusco, Alessio Filippo Peritore, Enrico Gugliandolo, Rosalia Crupi, Salvatore Cuzzocrea, Rosanna Di Paola, Daniela Impellizzeri, Tiziana Genovese. Ultramicronized Palmitoylethanolamide in the Management of Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation. International journal of molecular sciences. 2021 Oct; 22(21):. doi: 10.3390/ijms222111388. [PMID: 34768820]
  • Jae In Jung, Hyun Sook Lee, Young Eun Jeon, So Mi Kim, Su Hee Hong, Joo Myung Moon, Cho Young Lim, Yoon Hee Kim, Eun Ji Kim. Anti-inflammatory activity of palmitoylethanolamide ameliorates osteoarthritis induced by monosodium iodoacetate in Sprague-Dawley rats. Inflammopharmacology. 2021 Oct; 29(5):1475-1486. doi: 10.1007/s10787-021-00870-3. [PMID: 34468900]
  • Roberto De Icco, Rosaria Greco, Chiara Demartini, Pietro Vergobbi, Annamaria Zanaboni, Elena Tumelero, Angelo Reggiani, Natalia Realini, Grazia Sances, Valentina Grillo, Marta Allena, Cristina Tassorelli. Spinal nociceptive sensitization and plasma palmitoylethanolamide levels during experimentally induced migraine attacks. Pain. 2021 09; 162(9):2376-2385. doi: 10.1097/j.pain.0000000000002223. [PMID: 33587406]
  • L D'Ascanio, F Vitelli, C Cingolani, M Maranzano, M J Brenner, A Di Stadio. Randomized clinical trial 'olfactory dysfunction after COVID-19: olfactory rehabilitation therapy vs. intervention treatment with Palmitoylethanolamide and Luteolin': preliminary results. European review for medical and pharmacological sciences. 2021 06; 25(11):4156-4162. doi: 10.26355/eurrev_202106_26059. [PMID: 34156697]
  • Luca Roncati, Beatrice Lusenti, Federica Pellati, Lorenzo Corsi. Micronized / ultramicronized palmitoylethanolamide (PEA) as natural neuroprotector against COVID-19 inflammation. Prostaglandins & other lipid mediators. 2021 06; 154(?):106540. doi: 10.1016/j.prostaglandins.2021.106540. [PMID: 33636368]
  • Paul Clayton, Mariko Hill, Nathasha Bogoda, Silma Subah, Ruchitha Venkatesh. Palmitoylethanolamide: A Natural Compound for Health Management. International journal of molecular sciences. 2021 May; 22(10):. doi: 10.3390/ijms22105305. [PMID: 34069940]
  • Alex Mabou Tagne, Yannick Fotio, Lin Lin, Erica Squire, Faizy Ahmed, Tarif Ibne Rashid, Elnaz Karimian Azari, Daniele Piomelli. Palmitoylethanolamide and hemp oil extract exert synergistic anti-nociceptive effects in mouse models of acute and chronic pain. Pharmacological research. 2021 05; 167(?):105545. doi: 10.1016/j.phrs.2021.105545. [PMID: 33722712]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Alessia D'Aloia, Laura Molteni, Francesca Gullo, Elena Bresciani, Valentina Artusa, Laura Rizzi, Michela Ceriani, Ramona Meanti, Marzia Lecchi, Silvia Coco, Barbara Costa, Antonio Torsello. Palmitoylethanolamide Modulation of Microglia Activation: Characterization of Mechanisms of Action and Implication for Its Neuroprotective Effects. International journal of molecular sciences. 2021 Mar; 22(6):. doi: 10.3390/ijms22063054. [PMID: 33802689]
  • Emiliano Manzo, Aniello Schiano Moriello, Francesco Tinto, Roberta Verde, Marco Allarà, Luciano De Petrocellis, Ester Pagano, Angelo A Izzo, Vincenzo Di Marzo, Stefania Petrosino. A Glucuronic Acid-Palmitoylethanolamide Conjugate (GLUPEA) Is an Innovative Drug Delivery System and a Potential Bioregulator. Cells. 2021 02; 10(2):. doi: 10.3390/cells10020450. [PMID: 33672574]
  • Dong-Soon Im. GPR119 and GPR55 as Receptors for Fatty Acid Ethanolamides, Oleoylethanolamide and Palmitoylethanolamide. International journal of molecular sciences. 2021 Jan; 22(3):. doi: 10.3390/ijms22031034. [PMID: 33494185]
  • Yannick Fotio, Roberto Ciccocioppo, Daniele Piomelli. N-acylethanolamine acid amidase (NAAA) inhibition decreases the motivation for alcohol in Marchigian Sardinian alcohol-preferring rats. Psychopharmacology. 2021 Jan; 238(1):249-258. doi: 10.1007/s00213-020-05678-7. [PMID: 33037452]
  • Alex Y Pai, Cachet Wenziger, Elani Streja, Donovan A Argueta, Nicholas V DiPatrizio, Connie M Rhee, Nosratola D Vaziri, Kamyar Kalantar-Zadeh, Daniele Piomelli, Hamid Moradi. Impact of Circulating N-Acylethanolamine Levels with Clinical and Laboratory End Points in Hemodialysis Patients. American journal of nephrology. 2021; 52(1):59-68. doi: 10.1159/000513381. [PMID: 33601382]
  • Stefania Petrosino, Aniello Schiano Moriello. Palmitoylethanolamide: A Nutritional Approach to Keep Neuroinflammation within Physiological Boundaries-A Systematic Review. International journal of molecular sciences. 2020 Dec; 21(24):. doi: 10.3390/ijms21249526. [PMID: 33333772]
  • Alessia D'Aloia, Federica Arrigoni, Renata Tisi, Alessandro Palmioli, Michela Ceriani, Valentina Artusa, Cristina Airoldi, Giuseppe Zampella, Barbara Costa, Laura Cipolla. Synthesis, Molecular Modeling and Biological Evaluation of Metabolically Stable Analogues of the Endogenous Fatty Acid Amide Palmitoylethanolamide. International journal of molecular sciences. 2020 Nov; 21(23):. doi: 10.3390/ijms21239074. [PMID: 33260658]
  • Aysha Karim Kiani, Giacinto Abele Donato Miggiano, Barbara Aquilanti, Valeria Velluti, Giuseppina Matera, Lucilla Gagliardi, Matteo Bertelli. Food supplements based on palmitoylethanolamide plus hydroxytyrosol from olive tree or Bacopa monnieri extracts for neurological diseases. Acta bio-medica : Atenei Parmensis. 2020 11; 91(13-S):e2020007. doi: 10.23750/abm.v91i13-s.10582. [PMID: 33170159]
  • Annagrazia Adornetto, Laura Rombolà, Luigi Antonio Morrone, Carlo Nucci, Maria Tiziana Corasaniti, Giacinto Bagetta, Rossella Russo. Natural Products: Evidence for Neuroprotection to Be Exploited in Glaucoma. Nutrients. 2020 Oct; 12(10):. doi: 10.3390/nu12103158. [PMID: 33081127]
  • Antonio Gigante, Alberto Aquili, Luca Farinelli, Alessandro Caraffa, Gianpaolo Ronconi, Carla Enrica Gallenga, Giulia Tetè, Spyros K Kritas, Pio Conti. Sodium chromo-glycate and palmitoylethanolamide: A possible strategy to treat mast cell-induced lung inflammation in COVID-19. Medical hypotheses. 2020 Oct; 143(?):109856. doi: 10.1016/j.mehy.2020.109856. [PMID: 32460208]
  • Sarah Beggiato, Tommaso Cassano, Luca Ferraro, Maria C Tomasini. Astrocytic palmitoylethanolamide pre-exposure exerts neuroprotective effects in astrocyte-neuron co-cultures from a triple transgenic mouse model of Alzheimer's disease. Life sciences. 2020 Sep; 257(?):118037. doi: 10.1016/j.lfs.2020.118037. [PMID: 32622942]
  • E Appiah-Kusi, R Wilson, M Colizzi, E Foglia, E Klamerus, A Caldwell, M G Bossong, P McGuire, S Bhattacharyya. Childhood trauma and being at-risk for psychosis are associated with higher peripheral endocannabinoids. Psychological medicine. 2020 08; 50(11):1862-1871. doi: 10.1017/s0033291719001946. [PMID: 31422779]
  • Ramona D'Amico, Daniela Impellizzeri, Salvatore Cuzzocrea, Rosanna Di Paola. ALIAmides Update: Palmitoylethanolamide and Its Formulations on Management of Peripheral Neuropathic Pain. International journal of molecular sciences. 2020 Jul; 21(15):. doi: 10.3390/ijms21155330. [PMID: 32727084]
  • Daniele Piomelli, Laura Scalvini, Yannick Fotio, Alessio Lodola, Gilberto Spadoni, Giorgio Tarzia, Marco Mor. N-Acylethanolamine Acid Amidase (NAAA): Structure, Function, and Inhibition. Journal of medicinal chemistry. 2020 07; 63(14):7475-7490. doi: 10.1021/acs.jmedchem.0c00191. [PMID: 32191459]
  • Niclas Stensson, Björn Gerdle, Malin Ernberg, Kaisa Mannerkorpi, Eva Kosek, Bijar Ghafouri. Increased Anandamide and Decreased Pain and Depression after Exercise in Fibromyalgia. Medicine and science in sports and exercise. 2020 07; 52(7):1617-1628. doi: 10.1249/mss.0000000000002293. [PMID: 32168104]
  • Lea Tischmann, Mathijs Drummen, Peter J Joris, Blandine Gatta-Cherifi, Anne Raben, Mikael Fogelholm, Isabelle Matias, Daniela Cota, Ronald P Mensink, Margriet S Westerterp-Plantenga, Tanja C Adam. Effects of a High-Protein Diet on Cardiometabolic Health, Vascular Function, and Endocannabinoids-A PREVIEW Study. Nutrients. 2020 May; 12(5):. doi: 10.3390/nu12051512. [PMID: 32455987]
  • Dorian Forte, Flaminia Fanelli, Marco Mezzullo, Martina Barone, Giulia Corradi, Giuseppe Auteri, Daniela Bartoletti, Marina Martello, Emanuela Ottaviani, Carolina Terragna, Antonio Curti, Uberto Pagotto, Francesca Palandri, Michele Cavo, Lucia Catani. Disease-Specific Derangement of Circulating Endocannabinoids and N-Acylethanolamines in Myeloproliferative Neoplasms. International journal of molecular sciences. 2020 May; 21(9):. doi: 10.3390/ijms21093399. [PMID: 32403407]
  • Wenhui Jin, Longhe Yang, Zhiwei Yi, Hua Fang, Weizhu Chen, Zhuan Hong, Yiping Zhang, Guangya Zhang, Long Li. Anti-Inflammatory Effects of Fucoxanthinol in LPS-Induced RAW264.7 Cells through the NAAA-PEA Pathway. Marine drugs. 2020 Apr; 18(4):. doi: 10.3390/md18040222. [PMID: 32326173]
  • Alistair Mallard, David Briskey, Andrew Richards, Dean Mills, Amanda Rao. The Effect of Orally Dosed Levagen+™ (palmitoylethanolamide) on Exercise Recovery in Healthy Males-A Double-Blind, Randomized, Placebo-Controlled Study. Nutrients. 2020 Feb; 12(3):. doi: 10.3390/nu12030596. [PMID: 32106527]
  • Gianfranca Carta, Elisabetta Murru, Romina Vargiu, Maria Collu, Manolo Carta, Sebastiano Banni, Roberto Stancampiano. Essential fatty acids deficient diet modulates N-Acylethanolamide profile in rat's tissues. Prostaglandins, leukotrienes, and essential fatty acids. 2020 02; 153(?):102053. doi: 10.1016/j.plefa.2020.102053. [PMID: 31978675]
  • Chiara Annunziata, Adriano Lama, Claudio Pirozzi, Gina Cavaliere, Giovanna Trinchese, Francesca Di Guida, Allegra Nitrato Izzo, Fabiano Cimmino, Orlando Paciello, Davide De Biase, Elisabetta Murru, Sebastiano Banni, Antonio Calignano, Maria Pina Mollica, Giuseppina Mattace Raso, Rosaria Meli. Palmitoylethanolamide counteracts hepatic metabolic inflexibility modulating mitochondrial function and efficiency in diet-induced obese mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020 01; 34(1):350-364. doi: 10.1096/fj.201901510rr. [PMID: 31914699]
  • Bruno A Marichal-Cancino, Abimael González-Hernández, Antoinette MaassenVanDenBrink, Eduardo Ramírez-San Juan, Carlos M Villalón. Potential Mechanisms Involved in Palmitoylethanolamide-Induced Vasodepressor Effects in Rats. Journal of vascular research. 2020; 57(3):152-163. doi: 10.1159/000506158. [PMID: 32248195]
  • Miguel Gómez-Boronat, Esther Isorna, Marta Conde-Sieira, María J Delgado, José L Soengas, Nuria de Pedro. First evidence on the role of palmitoylethanolamide in energy homeostasis in fish. Hormones and behavior. 2020 01; 117(?):104609. doi: 10.1016/j.yhbeh.2019.104609. [PMID: 31647920]
  • Erin C Hanlon. Impact of circadian rhythmicity and sleep restriction on circulating endocannabinoid (eCB) N-arachidonoylethanolamine (anandamide). Psychoneuroendocrinology. 2020 01; 111(?):104471. doi: 10.1016/j.psyneuen.2019.104471. [PMID: 31610409]
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