Estradiol Benzoate (BioDeep_00000002595)

   


代谢物信息卡片


(17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl) benzoate

化学式: C25H28O3 (376.2038)
中文名称: 苯甲酸雌二醇
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)OC(=O)C5=CC=CC=C5
InChI: InChI=1S/C25H28O3/c1-25-14-13-20-19-10-8-18(28-24(27)16-5-3-2-4-6-16)15-17(19)7-9-21(20)22(25)11-12-23(25)26/h2-6,8,10,15,20-23,26H,7,9,11-14H2,1H3/t20-,21-,22+,23+,25+/m1/s1

描述信息

C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C483 - Therapeutic Estrogen
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
D012102 - Reproductive Control Agents > D003270 - Contraceptive Agents
Same as: D01953

同义名列表

6 个代谢物同义名

17-beta-Estradiol 3-benzoate; Estradiol Benzoate; (17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl) benzoate; estra-1,3,5(10)-triene-3,17β-diol 3-benzoate; Estradiol benzoate; Estradiol benzoate



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 CA1, CA3, CASP3, CAT, ESR1, GJA1, GJB3, PGR, PRL, TH
Peripheral membrane protein 1 ESR1
Endoplasmic reticulum membrane 4 GJA1, GJB1, GJC1, HSP90B1
Nucleus 8 CASP3, ESR1, ESR2, GJA1, HSP90B1, PGR, PRL, TH
cytosol 9 CA1, CA3, CASP3, CAT, ESR1, GJA1, HSP90B1, PGR, TH
dendrite 1 TH
nucleoplasm 8 CASP3, ESR1, ESR2, GJA1, GJB4, GJC1, PGR, PRL
RNA polymerase II transcription regulator complex 1 PRL
Cell membrane 8 ESR1, GJA1, GJA4, GJA5, GJB1, GJB4, GJC1, TNF
Cytoplasmic side 1 ESR1
Cell projection, axon 1 TH
Multi-pass membrane protein 6 GJA1, GJA4, GJA5, GJB1, GJB4, GJC1
Synapse 1 GJC1
cell junction 3 GJA1, GJB3, GJB4
cell surface 2 GJC1, TNF
glutamatergic synapse 1 CASP3
Golgi apparatus 2 ESR1, GJA1
Golgi membrane 2 GJA1, INS
neuronal cell body 2 CASP3, TNF
smooth endoplasmic reticulum 2 HSP90B1, TH
synaptic vesicle 1 TH
plasma membrane 8 ESR1, GJA1, GJA4, GJA5, GJB4, GJC1, PGR, TNF
terminal bouton 1 TH
Membrane 3 CAT, ESR1, HSP90B1
apical plasma membrane 1 GJA1
axon 1 TH
extracellular exosome 3 CA1, CAT, HSP90B1
endoplasmic reticulum 3 GJA1, GJC1, HSP90B1
extracellular space 4 GNRH1, INS, PRL, TNF
perinuclear region of cytoplasm 2 HSP90B1, TH
gap junction 5 GJA1, GJA4, GJA5, GJB3, GJC1
intercalated disc 3 GJA1, GJA5, GJC1
mitochondrion 4 CAT, ESR2, GJA1, TH
protein-containing complex 3 CAT, ESR1, HSP90B1
intracellular membrane-bounded organelle 4 CAT, ESR2, GJA1, GJB3
postsynaptic density 1 CASP3
Secreted 2 INS, PRL
extracellular region 6 CAT, GNRH1, HSP90B1, INS, PRL, TNF
cytoplasmic side of plasma membrane 1 TH
mitochondrial outer membrane 1 PGR
mitochondrial matrix 1 CAT
transcription regulator complex 1 ESR1
external side of plasma membrane 1 TNF
perikaryon 1 TH
cytoplasmic vesicle 1 TH
nucleolus 1 GJB4
Melanosome membrane 1 TH
midbody 1 HSP90B1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Cytoplasm, perinuclear region 1 TH
Membrane raft 2 GJA1, TNF
focal adhesion 3 CAT, GJA1, HSP90B1
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 HSP90B1
Cell junction, gap junction 6 GJA1, GJA4, GJA5, GJB1, GJB4, GJC1
connexin complex 7 GJA1, GJA4, GJA5, GJB1, GJB3, GJB4, GJC1
contractile muscle fiber 1 GJA1
fascia adherens 1 GJA1
intermediate filament 1 GJA1
lateral plasma membrane 2 GJA1, GJB1
neuron projection 1 TH
chromatin 4 ESR1, ESR2, PGR, PRL
cell projection 1 GJA5
phagocytic cup 1 TNF
endosome lumen 2 INS, PRL
Melanosome 1 HSP90B1
Golgi-associated vesicle membrane 1 GJA1
euchromatin 1 ESR1
sperm plasma membrane 1 HSP90B1
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 HSP90B1, INS
transport vesicle 1 INS
tight junction 1 GJA1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
Sarcoplasmic reticulum lumen 1 HSP90B1
[Isoform 1]: Nucleus 1 ESR1
death-inducing signaling complex 1 CASP3
cell-cell contact zone 1 GJA1
endocytic vesicle lumen 1 HSP90B1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
[Isoform 4]: Mitochondrion outer membrane 1 PGR
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle 1 TH
endoplasmic reticulum chaperone complex 1 HSP90B1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Adeola Olowofolahan, Omowumi Fatunsin, Olufunso Olorunsogo. Modulatory effect of ciprofloxacin, a broad spectrum antibacterial drug, on mPT pore using rat model with estradiol benzoate-induced endometrial hyperplasia. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Nov; ?(?):. doi: 10.1007/s00210-023-02824-8. [PMID: 37943297]
  • Ke Sui, Ali Yasrebi, Natasha Malonza, Zehra H Jaffri, Samuel E Fisher, Isaac Seelenfreund, Brandon D McGuire, Savannah A Martinez, Avery T MacDonell, Kevin M Tveter, Candace R Longoria, Sue A Shapses, Sara C Campbell, Diana E Roopchand, Troy A Roepke. Saturated fatty acids and omega-3 polyunsaturated fatty acids improve metabolic parameters in ovariectomized female mice. Endocrinology. 2023 Apr; ?(?):. doi: 10.1210/endocr/bqad059. [PMID: 37029960]
  • Anqi Wang, Kexin Zhang, Chunyan Fu, Changming Zhou, Zhengui Yan, Xuelan Liu. Alleviation effect of conjugated linoleic acid on estradiol benzoate induced fatty liver hemorrhage syndrome in Hy-line male chickens. Journal of animal science. 2023 Feb; ?(?):. doi: 10.1093/jas/skad045. [PMID: 36751705]
  • Yangyun Wang, Chaoliang Shi, Wandong Yu, Wei Jiao, Guowei Shi. Efficacy of Yougui pill combined with Buzhong Yiqi decoction in alleviating the sexual dysfunction in female rats through modulation of the gut microbiota. Pharmaceutical biology. 2022 Dec; 60(1):46-55. doi: 10.1080/13880209.2021.2010774. [PMID: 34904911]
  • Gilmar Arantes Ataide Junior, Anderson Kloster, Émerson Guimarães de Moraes, Igor Garcia Motta, Izaias Claro Junior, José Luiz M Vasconcelos, Priscila Assis Ferraz, Guilherme de Paula Nogueira, Guilherme Pugliesi. Early resynchronization of follicular wave emergence among Nelore cattle using injectable and intravaginal progesterone for three timed artificial inseminations. Animal reproduction science. 2021 Jun; 229(?):106759. doi: 10.1016/j.anireprosci.2021.106759. [PMID: 34015725]
  • Eugene D Albrecht, Jeffery S Babischkin, Graham W Aberdeen, Marcia G Burch, Gerald J Pepe. Maternal systemic vascular dysfunction in a primate model of defective uterine spiral artery remodeling. American journal of physiology. Heart and circulatory physiology. 2021 04; 320(4):H1712-H1723. doi: 10.1152/ajpheart.00613.2020. [PMID: 33666502]
  • Adeola O Olowofolahan, Olubukola T Oyebode, Olufunso O Olorunsogo. Methyl palmitate reversed estradiol benzoate-induced endometrial hyperplasia in female rats. Toxicology mechanisms and methods. 2021 Jan; 31(1):43-52. doi: 10.1080/15376516.2020.1827329. [PMID: 32967526]
  • Yoshajandith Aguirre-Vidal, Jorge Morales-Montor, Carmen T Gómez de León, Pedro Ostoa-Saloma, Mariana Díaz-Zaragoza, Sergio Montes, Marcela Arteaga-Silva, Antonio Monroy-Noyola. Protection induced by estradiol benzoate in the MPP+ rat model of Parkinson's disease is associated with the regulation of the inflammatory cytokine profile in the nigro striatum. Journal of neuroimmunology. 2020 12; 349(?):577426. doi: 10.1016/j.jneuroim.2020.577426. [PMID: 33096292]
  • Lindomar Sousa Brito, Luiz Di Paolo Maggitti Junior, Priscila Assis Ferraz, Isabela Costa Vasconcelos, João Vitor Gomes da Silva Carvalho, Marcus Vinicius Galvão Loiola, Rodrigo Freitas Bittencourt, Mónica Madrigal-Valverde, Ana Karina da Silva Cavalcante, Larissa Pires Barbosa, Lilian Porto da Oliveira, Morgana Cardoso Brasileiro Borges Bastos, Osvaldo Santos de Brito, Antônio de Lisboa Ribeiro Filho. Effects of equine chorionic gonadotropin administered via the Baihui acupoint on follicular ovarian dynamics and the luteal function of cattle during an ovulation synchronization treatment regimen for fixed-time artificial insemination. Animal reproduction science. 2020 Dec; 223(?):106631. doi: 10.1016/j.anireprosci.2020.106631. [PMID: 33137692]
  • Noriko Nakamura, Lisa M Pence, Zhijun Cao, Richard D Beger. Distinct lipid signatures are identified in the plasma of rats with chronic inflammation induced by estradiol benzoate and sex hormones. Metabolomics : Official journal of the Metabolomic Society. 2020 09; 16(9):95. doi: 10.1007/s11306-020-01715-w. [PMID: 32895772]
  • Marcelo Vedovatto, Philipe Moriel, Reinaldo F Cooke, Deiler S Costa, Fábio J C Faria, Ibrahim M Cortada Neto, Anderson L L Bento, Raizza F A T Rocha, Luiz C L Ferreira, Ricardo G Almeida, Sandra A Santos, Gumercindo L Franco. Effects of a single trace mineral injection at beginning of fixed-time AI treatment regimen on reproductive function and antioxidant response of grazing Nellore cows. Animal reproduction science. 2019 Dec; 211(?):106234. doi: 10.1016/j.anireprosci.2019.106234. [PMID: 31785632]
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  • Mengting Wang, Yang Wang, Bin Peng, Na Zhao, Jing Zhao, Zhili Xiong, Longshan Zhao. Multi-class determination of steroid hormones and antibiotics in fatty hotpot ingredients by pressurized liquid extraction and liquid chromatography-tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2019 Jul; 171(?):193-203. doi: 10.1016/j.jpba.2019.04.019. [PMID: 31009874]
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  • Shiori Minabe, Marimo Sato, Naoko Inoue, Youki Watanabe, Fumie Magata, Fuko Matsuda, Yoshihisa Uenoyama, Hitoshi Ozawa, Hiroko Tsukamura. Neonatal Estrogen Causes Irreversible Male Infertility via Specific Suppressive Action on Hypothalamic Kiss1 Neurons. Endocrinology. 2019 05; 160(5):1223-1233. doi: 10.1210/en.2018-00732. [PMID: 30920587]
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  • Thaís Abritta Zacarias, Taynan Stonoga Kawamoto, João Ricardo Scaliante Júnior, Ana Luiza Silva Guimarães, Maurício Machaim Franco, Ricardo Alamino Figueiredo. Hormonal stimulation in 4 to 7 months old Nelore (Bos taurus indicus) females improved ovarian follicular responses but not the in vitro embryo production. Theriogenology. 2018 Sep; 118(?):130-136. doi: 10.1016/j.theriogenology.2018.05.039. [PMID: 29906662]
  • T Kunkhyen, E Perez, M Bass, A Coyne, M J Baum, J A Cherry. Gonadal hormones, but not sex, affect the acquisition and maintenance of a Go/No-Go odor discrimination task in mice. Hormones and behavior. 2018 04; 100(?):12-19. doi: 10.1016/j.yhbeh.2018.02.009. [PMID: 29481807]
  • Matthew R Green, Marina L Marcolin, Cheryl M McCormick. The effects of ovarian hormones on stressor-induced hormonal responses, glucocorticoid receptor expression and translocation, and genes related to receptor signaling in adult female rats. Stress (Amsterdam, Netherlands). 2018 03; 21(2):90-100. doi: 10.1080/10253890.2017.1409719. [PMID: 29189098]
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  • Marwa M M Refaie, Maram El-Hussieny. Diacerein inhibits Estradiol-benzoate induced cervical hyperkeratosis in female rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Nov; 95(?):223-229. doi: 10.1016/j.biopha.2017.08.053. [PMID: 28843910]
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  • Jeong-Eun Choi, Yongsoon Park. EPA and DHA, but not ALA, have antidepressant effects with 17β-estradiol injection via regulation of a neurobiological system in ovariectomized rats. The Journal of nutritional biochemistry. 2017 11; 49(?):101-109. doi: 10.1016/j.jnutbio.2017.07.012. [PMID: 28915388]
  • Joanna Maria Gonçalves Souza-Fabjan, Rômulo Mendonça da Rosa, Mário Felipe Alvarez Balaro, Pedro Henrique Nicolau Pinto, Gustavo Bervian Dos Santos, Eduardo Kenji Nunes Arashiro, Jeferson Ferreira da Fonseca, Rodolfo Ungerfeld, Felipe Zandonadi Brandão. Effect of different hormonal combinations on follicular wave emergence and superovulatory response in sheep. Theriogenology. 2017 Nov; 103(?):24-29. doi: 10.1016/j.theriogenology.2017.07.036. [PMID: 28763726]
  • Álvaro Anzai, Rodrigo R Marcondes, Thiago H Gonçalves, Kátia C Carvalho, Manuel J Simões, Natália Garcia, José M Soares, Vasantha Padmanabhan, Edmund C Baracat, Ismael D C G da Silva, Gustavo A R Maciel. Impaired branched-chain amino acid metabolism may underlie the nonalcoholic fatty liver disease-like pathology of neonatal testosterone-treated female rats. Scientific reports. 2017 10; 7(1):13167. doi: 10.1038/s41598-017-13451-8. [PMID: 29030588]
  • Yoshajandith Aguirre-Vidal, Antonio Monroy-Noyola, Laura Anaya-Ramos, Marcela Arteaga-Silva, Marisela Mendez-Armenta, Pedro Ostoa-Saloma, Mariana Díaz-Zaragoza, Jorge Morales-Montor, Camilo Ríos, Sergio Montes. β-Estradiol-3-benzoate confers neuroprotection in Parkinson MPP+ rat model through inhibition of lipid peroxidation. Steroids. 2017 10; 126(?):7-14. doi: 10.1016/j.steroids.2017.08.001. [PMID: 28827046]
  • Rahmatollah Parandin, Morteza Behnam-Rassouli, Nasser Mahdavi-Shahri. Effects of Neonatal Exposure to Zearalenone on Puberty Timing, Hypothalamic Nuclei of AVPV and ARC, and Reproductive Functions in Female Mice. Reproductive sciences (Thousand Oaks, Calif.). 2017 09; 24(9):1293-1303. doi: 10.1177/1933719116683808. [PMID: 28814190]
  • Marwa M M Refaie, Maram El-Hussieny. The role of interleukin-1b and its antagonist (diacerein) in estradiol benzoate-induced endometrial hyperplasia and atypia in female rats. Fundamental & clinical pharmacology. 2017 Aug; 31(4):438-446. doi: 10.1111/fcp.12285. [PMID: 28299811]
  • Gail S Prins, Shu-Hua Ye, Lynn Birch, Xiang Zhang, Ana Cheong, Han Lin, Esther Calderon-Gierszal, Jacob Groen, Wen-Yang Hu, Shuk-Mei Ho, Richard B van Breemen. Prostate Cancer Risk and DNA Methylation Signatures in Aging Rats following Developmental BPA Exposure: A Dose-Response Analysis. Environmental health perspectives. 2017 07; 125(7):077007. doi: 10.1289/ehp1050. [PMID: 28728135]
  • T Motavalli, E Dirandeh, H Deldar, M G Colazo. Evaluation of shortened timed-AI protocols for resynchronization of ovulation in multiparous Holstein dairy cows. Theriogenology. 2017 Jun; 95(?):187-192. doi: 10.1016/j.theriogenology.2017.03.003. [PMID: 28460675]
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  • Martina Rejtharová, Libor Rejthar, Katarína Čačková. Determination of testosterone esters and estradiol esters in bovine and porcine blood serum. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2017 Apr; 34(4):477-481. doi: 10.1080/19440049.2016.1268272. [PMID: 27915587]
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