Papaverine (BioDeep_00000002550)

 

Secondary id: BioDeep_00000398524, BioDeep_00000865383

human metabolite blood metabolite


代谢物信息卡片


1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy isoquinoline

化学式: C20H21NO4 (339.14705060000006)
中文名称:
谱图信息: 最多检出来源 Macaca mulatta(otcml) 0.08%

分子结构信息

SMILES: COC1=C(C=C(C=C1)CC2=NC=CC3=CC(=C(C=C32)OC)OC)OC
InChI: InChI=1S/C20H21NO4/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16/h5-8,10-12H,9H2,1-4H3

描述信息

Papaverine is an alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels. [PubChem].
A - Alimentary tract and metabolism > A03 - Drugs for functional gastrointestinal disorders > A03A - Drugs for functional gastrointestinal disorders > A03AD - Papaverine and derivatives
G - Genito urinary system and sex hormones > G04 - Urologicals > G04B - Urologicals > G04BE - Drugs used in erectile dysfunction
D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids
C78274 - Agent Affecting Cardiovascular System > C29707 - Vasodilating Agent
D004791 - Enzyme Inhibitors > D010726 - Phosphodiesterase Inhibitors
D000089162 - Genitourinary Agents > D064804 - Urological Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
C471 - Enzyme Inhibitor > C744 - Phosphodiesterase Inhibitor
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 2252
Alkaloid from Papaver somniferum (opium poppy)

同义名列表

15 个代谢物同义名

1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy isoquinoline; 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinoline; Papaverine monohydrochloride; Chlorhydrate de papaverine; Hydrochloride, Papaverine; Papaverine Hydrochloride; Papaverine chlorohydrate; Papavarine chlorhydrate; Papaverinium chloride; Papaverine; Papaverin; Cerespan; Mesotina; Pavabid; Pavatym



数据库引用编号

40 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

51 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(50)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Najeeb Ur Rehman, Mohd Nazam Ansari, Wasim Ahmad, Mohd Amir. The Detailed Pharmacodynamics of the Gut Relaxant Effect and GC-MS Analysis of the Grewia tenax Fruit Extract: In Vivo and Ex Vivo Approach. Molecules (Basel, Switzerland). 2022 Dec; 27(24):. doi: 10.3390/molecules27248880. [PMID: 36558012]
  • Daniella Anthea Gomes, Anna Margaretha Joubert, Michelle Helen Visagie. The Biological Relevance of Papaverine in Cancer Cells. Cells. 2022 10; 11(21):. doi: 10.3390/cells11213385. [PMID: 36359780]
  • Osman K Jamil, Aaron Cravens, James T Payne, Colin Y Kim, Christina D Smolke. Biosynthesis of tetrahydropapaverine and semisynthesis of papaverine in yeast. Proceedings of the National Academy of Sciences of the United States of America. 2022 08; 119(33):e2205848119. doi: 10.1073/pnas.2205848119. [PMID: 35939674]
  • Jihion Yu, Jun-Young Park, Jai-Hyun Hwang, Cheryn Song, Young-Kug Kim. Effect of Papaverine on Renal Artery Blood Flow during Robot-Assisted Partial Nephrectomy: A Randomized Controlled Study. Annals of surgical oncology. 2022 Aug; 29(8):5321-5329. doi: 10.1245/s10434-022-11586-1. [PMID: 35368220]
  • Jihion Yu, Cheryn Song, Young-Kug Kim. ASO Author Reflections: Papaverine and Beneficial Renal Effects in Robot-Assisted Partial Nephrectomy. Annals of surgical oncology. 2022 08; 29(8):5330-5331. doi: 10.1245/s10434-022-11619-9. [PMID: 35347516]
  • Najeeb Ur Rehman, Mohd Nazam Ansari, Wasim Ahmad, Mohd Amir. GC-MS Analysis and In Vivo and Ex Vivo Antidiarrheal and Antispasmodic Effects of the Methanolic Extract of Acacia nilotica. Molecules (Basel, Switzerland). 2022 Mar; 27(7):. doi: 10.3390/molecules27072107. [PMID: 35408506]
  • Magdalena Antonowicz, Janusz Szewczenko, Anita Kajzer, Wojciech Kajzer, Joanna Jaworska, Katarzyna Jelonek, Paulina Karpeta-Jarząbek, Piotr Bryniarski, Maciej Krzywiecki, Lucyna Grządziel, Andrzej S Swinarew, Damian S Nakonieczny, Janusz Kasperczyk. Assessment of encrustation and physicochemical properties of poly(lactide-glycolide) - Papaverine hydrochloride coating on ureteral double-J stents after long-term flow of artificial urine. Journal of biomedical materials research. Part B, Applied biomaterials. 2022 02; 110(2):367-381. doi: 10.1002/jbm.b.34913. [PMID: 34302425]
  • Hideaki Tanaka, Hidenari Matsumoto, Haruya Takahashi, Masahiro Hosonuma, Shunya Sato, Kunihiro Ogura, Yosuke Oishi, Ryota Masaki, Koshiro Sakai, Teruo Sekimoto, Seita Kondo, Hiroaki Tsujita, Shigeto Tsukamoto, Arihiro Sumida, Natsumi Okada, Kazuo Inoue, Toshiro Shinke. Linear concentration-response relationship of serum caffeine with adenosine-induced fractional flow reserve overestimation: a comparison with papaverine. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology. 2021 Dec; 17(11):e925-e931. doi: 10.4244/eij-d-21-00453. [PMID: 34647891]
  • Tuğçe Teker, Mehmet Aslanoglu. Development of a Dy2O3@Eu2O3-carbon nanofiber based electrode for highly sensitive detection of papaverine. Analytica chimica acta. 2021 Oct; 1183(?):338972. doi: 10.1016/j.aca.2021.338972. [PMID: 34627531]
  • Priyanka Agarwal, Sairam Behera, Ilva Dana Rupenthal. Ocular Distribution of Papaverine Using Non-aqueous Vehicles. AAPS PharmSciTech. 2021 May; 22(5):160. doi: 10.1208/s12249-021-02050-6. [PMID: 34031787]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Phani Krishna Parcha, Sailu Sarvagalla, Cheemala Ashok, S J Sudharshan, Madhu Dyavaiah, Mohane Selvaraj Coumar, Baskaran Rajasekaran. Repositioning antispasmodic drug Papaverine for the treatment of chronic myeloid leukemia. Pharmacological reports : PR. 2021 Apr; 73(2):615-628. doi: 10.1007/s43440-020-00196-x. [PMID: 33389727]
  • Duaa Eliwa, Mohamed A Albadry, Abdel-Rahim S Ibrahim, Amal Kabbash, Kumudini Meepagala, Ikhlas A Khan, Mona El-Aasr, Samir A Ross. Biotransformation of papaverine and in silico docking studies of the metabolites on human phosphodiesterase 10a. Phytochemistry. 2021 Mar; 183(?):112598. doi: 10.1016/j.phytochem.2020.112598. [PMID: 33360527]
  • Bernhard Ellinger, Denisa Bojkova, Andrea Zaliani, Jindrich Cinatl, Carsten Claussen, Sandra Westhaus, Oliver Keminer, Jeanette Reinshagen, Maria Kuzikov, Markus Wolf, Gerd Geisslinger, Philip Gribbon, Sandra Ciesek. A SARS-CoV-2 cytopathicity dataset generated by high-content screening of a large drug repurposing collection. Scientific data. 2021 02; 8(1):70. doi: 10.1038/s41597-021-00848-4. [PMID: 33637768]
  • Narjes Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Bushra Mdkhana, Saba Al Heialy, Elaref Ratemi, Malak Alghamdi, Salah Abusnana, Tarek Kashour, Qutayba Hamid, Rabih Halwani. Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue. Archives of toxicology. 2020 12; 94(12):4037-4041. doi: 10.1007/s00204-020-02869-1. [PMID: 32808185]
  • Blanka Miková, Miloš Dvořák, Lenka Ryšavá, Pavel Kubáň. Hollow Fiber Liquid-Phase Microextraction At-Line Coupled to Capillary Electrophoresis for Direct Analysis of Human Body Fluids. Analytical chemistry. 2020 05; 92(10):7171-7178. doi: 10.1021/acs.analchem.0c00697. [PMID: 32289222]
  • Megha Aggarwal, George P Leser, Robert A Lamb. Repurposing Papaverine as an Antiviral Agent against Influenza Viruses and Paramyxoviruses. Journal of virology. 2020 02; 94(6):. doi: 10.1128/jvi.01888-19. [PMID: 31896588]
  • Ali Farahani, Hassan Sereshti. An integrated microfluidic device for solid-phase extraction and spectrophotometric detection of opium alkaloids in urine samples. Analytical and bioanalytical chemistry. 2020 Jan; 412(1):129-138. doi: 10.1007/s00216-019-02214-1. [PMID: 31773230]
  • William M Armstead, Monica S Vavilala. Cerebral Perfusion Pressure Directed-Therapy Modulates Cardiac Dysfunction After Traumatic Brain Injury to Influence Cerebral Autoregulation in Pigs. Neurocritical care. 2019 12; 31(3):476-485. doi: 10.1007/s12028-019-00735-2. [PMID: 31115824]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Folake A Egbewande, Mark J Coster, Ian D Jenkins, Rohan A Davis. Reaction of Papaverine with Baran DiversinatesTM. Molecules (Basel, Switzerland). 2019 Oct; 24(21):. doi: 10.3390/molecules24213938. [PMID: 31683610]
  • Ahmad Pourahadi, Ali Farahani, Saied Saeed Hosseiny Davarani, Saeed Nojavan, Camellia Tashakori. Developing a miniaturized setup for in-tube simultaneous determination of three alkaloids using electromembrane extraction in combination with ultraviolet spectrophotometry. Journal of separation science. 2019 Oct; 42(19):3126-3133. doi: 10.1002/jssc.201900276. [PMID: 31347772]
  • Parul Agarwal, Sumya Pathak, Ravi Shankar Kumar, Yogeshwar Vikram Dhar, Ashutosh Pandey, Sudhir Shukla, Prabodh Kumar Trivedi. 3'O-Methyltransferase, Ps3'OMT, from opium poppy: involvement in papaverine biosynthesis. Plant cell reports. 2019 Oct; 38(10):1235-1248. doi: 10.1007/s00299-019-02439-5. [PMID: 31190213]
  • Carl E Wolf, Kaitlin L Pierce, Brett L Goldfine, Carrol R Nanco, Justin L Poklis, William J Korzun. Using Papaverine and Its Metabolites, 6-Desmethyl Papaverine and 4',6-Didesmethyl Papaverine as Biomarkers to Improve the Detection Time of Heroin Use. Journal of analytical toxicology. 2019 Sep; 43(8):600-606. doi: 10.1093/jat/bkz069. [PMID: 31436291]
  • Zeina Harhous, Sally Badawi, Noelle Gallo Bona, Bruno Pillot, Lionel Augeul, Melanie Paillard, George W Booz, Emmanuelle Canet-Soulas, Michel Ovize, Mazen Kurdi, Gabriel Bidaux. Critical appraisal of STAT3 pattern in adult cardiomyocytes. Journal of molecular and cellular cardiology. 2019 06; 131(?):91-100. doi: 10.1016/j.yjmcc.2019.04.021. [PMID: 31022374]
  • Jing Han, Wei Liu, Rui Su, Lixue Zhu, Debo Wu, Jiaquan Xu, Aiying Liu, Hua Zhang, Wei Kou, Xiaoping Zhang, Shuiping Yang. Coupling of micro-solid-phase extraction and internal extractive electrospray ionization mass spectrometry for ultra-sensitive detection of 1-hydroxypyrene and papaverine in human urine samples. Analytical and bioanalytical chemistry. 2019 Jun; 411(15):3281-3290. doi: 10.1007/s00216-019-01794-2. [PMID: 30989270]
  • Gholamreza Kazemzadeh, Ali Saberi, Reza Manani, Fatemeh Sadeghipour, Asghar Rahmani. Effect of local papaverine on arteriovenous fistula maturation in patients with end-stage renal disease. Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia. 2019 Apr; 41(2):185-192. doi: 10.1590/2175-8239-jbn-2018-0170. [PMID: 31498862]
  • Ying Shi, Guangya Shi, Zhenyu Li, Yanfang Chen, Shaohui Tang, Wei Huang. Superior mesenteric artery syndrome coexists with Nutcracker syndrome in a female: a case report. BMC gastroenterology. 2019 Jan; 19(1):15. doi: 10.1186/s12876-019-0932-1. [PMID: 30674275]
  • Rachel K Smith, Rebecca J Stacey, Ed Bergström, Jane Thomas-Oates. Detection of opium alkaloids in a Cypriot base-ring juglet. The Analyst. 2018 Oct; 143(21):5127-5136. doi: 10.1039/c8an01040d. [PMID: 30280166]
  • Robin A C Graham-Brown, Mark F Healsmith. From folklore to pharmacy: Putting plants into practice. Clinics in dermatology. 2018 May; 36(3):282-288. doi: 10.1016/j.clindermatol.2018.03.002. [PMID: 29908569]
  • Manuel Pereira Marques Gomes Júnior, Cláudia Maria Rodrigues Alves, Adriano Henrique Pereira Barbosa, Adriano Caixeta, Marcelo Costa Batista, José Osmar Medina Pestana, Antônio Carlos Carvalho. Initial experience with the use of fractional flow reserve in the hemodynamic evaluation of transplant renal artery stenosis. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. 2018 03; 91(4):820-826. doi: 10.1002/ccd.27476. [PMID: 29411509]
  • Igor Sorokin, Sharnae L Stevens, Jeffrey A Cadeddu. Periarterial papaverine to treat renal artery vasospasm during robot-assisted laparoscopic partial nephrectomy. Journal of robotic surgery. 2018 Mar; 12(1):189-191. doi: 10.1007/s11701-017-0710-4. [PMID: 28455799]
  • Andrea Šlampová, Pavel Kubáň. Direct Analysis of Free Aqueous and Organic Operational Solutions as a Tool for Understanding Fundamental Principles of Electromembrane Extraction. Analytical chemistry. 2017 12; 89(23):12960-12967. doi: 10.1021/acs.analchem.7b03829. [PMID: 29083873]
  • Serhat Huseyin, Orkut Guclu, Volkan Yüksel, Gulen Sezer Alptekin Erkul, Nuray Can, Fatma Nesrin Turan, Suat Canbaz. Avoiding Liver Injury with Papaverine and Ascorbic Acid Due to Infrarenal Cross-Clamping: an Experimental Study. Brazilian journal of cardiovascular surgery. 2017 May; 32(3):197-201. doi: 10.21470/1678-9741-2016-0081. [PMID: 28832798]
  • Juthamas Khamseekaew, Sirinart Kumfu, Suwakon Wongjaikam, Sasiwan Kerdphoo, Thidarat Jaiwongkam, Somdet Srichairatanakool, Suthat Fucharoen, Siriporn C Chattipakorn, Nipon Chattipakorn. Effects of iron overload, an iron chelator and a T-Type calcium channel blocker on cardiac mitochondrial biogenesis and mitochondrial dynamics in thalassemic mice. European journal of pharmacology. 2017 Mar; 799(?):118-127. doi: 10.1016/j.ejphar.2017.02.015. [PMID: 28192097]
  • Brij K Mishra, R Mishra, S N Jena, Sudhir Shukla. Gene actions for yield and its attributes and their implications in the inheritance pattern over three generations in opium poppy (Papaver somniferum L.). Journal of genetics. 2016 Sep; 95(3):705-17. doi: 10.1007/s12041-016-0689-z. [PMID: 27659342]
  • Parul Agarwal, Sumya Pathak, Deepika Lakhwani, Parul Gupta, Mehar Hasan Asif, Prabodh Kumar Trivedi. Comparative analysis of transcription factor gene families from Papaver somniferum: identification of regulatory factors involved in benzylisoquinoline alkaloid biosynthesis. Protoplasma. 2016 May; 253(3):857-871. doi: 10.1007/s00709-015-0848-8. [PMID: 26108744]
  • José Fernando Polanski, Alexandra Dezani Soares, Oswaldo Laércio de Mendonça Cruz. Antioxidant therapy in the elderly with tinnitus. Brazilian journal of otorhinolaryngology. 2016 May; 82(3):269-74. doi: 10.1016/j.bjorl.2015.04.016. [PMID: 26547700]
  • Anikó Lajtai, Mátyás Mayer, Ágnes Lakatos, Zoltán Porpáczy, Attila Miseta. Embutramide, a Component of Tanax(®) (T-61) as a New Drug of Abuse?. Journal of forensic sciences. 2016 Mar; 61(2):573-575. doi: 10.1111/1556-4029.13010. [PMID: 27404634]
  • Teresa Mastantuono, Noemy Starita, Daniela Sapio, Sabato Andrea D'Avanzo, Martina Di Maro, Espedita Muscariello, Marco Paterni, Antonio Colantuoni, Dominga Lapi. The Effects of Vaccinium myrtillus Extract on Hamster Pial Microcirculation during Hypoperfusion-Reperfusion Injury. PloS one. 2016; 11(4):e0150659. doi: 10.1371/journal.pone.0150659. [PMID: 27070318]
  • Shingo Hosoo, Masahiro Koyama, Mai Kato, Tetsuya Hirata, Yasuyo Yamaguchi, Hiroo Yamasaki, Atsunori Wada, Keiji Wada, Sansei Nishibe, Kozo Nakamura. The Restorative Effects of Eucommia ulmoides Oliver Leaf Extract on Vascular Function in Spontaneously Hypertensive Rats. Molecules (Basel, Switzerland). 2015 Dec; 20(12):21971-81. doi: 10.3390/molecules201219826. [PMID: 26690110]
  • Scott C Farrow, Peter J Facchini. Papaverine 7-O-demethylase, a novel 2-oxoglutarate/Fe(2+)-dependent dioxygenase from opium poppy. FEBS letters. 2015 Sep; 589(19 Pt B):2701-6. doi: 10.1016/j.febslet.2015.07.042. [PMID: 26264169]
  • Hongliang Li, Xi Zhu, Gaiqi Yao, Zongyu Wang. Papaverine improves sublingual blood flow in patients with septic shock. The Journal of surgical research. 2015 May; 195(1):271-6. doi: 10.1016/j.jss.2015.01.016. [PMID: 25676464]
  • Regina Kasperek, Łukasz Zimmer, Wojciech Jawień, Ewa Poleszak. PHARMACOKINETICS OF DICLOFENAC SODIUM AND PAPAVERINE HYDROCHLORIDE AFTER ORAL ADMINISTRATION OF TABLETS TO RABBITS. Acta poloniae pharmaceutica. 2015 May; 72(3):527-38. doi: NULL. [PMID: 26642661]
  • Mohammad-Bagher Gholivand, Ali R Jalalvand, Hector C Goicoechea, Raimundo Gargallo, Thomas Skov, Giti Paimard. Combination of electrochemistry with chemometrics to introduce an efficient analytical method for simultaneous quantification of five opium alkaloids in complex matrices. Talanta. 2015 Jan; 131(?):26-37. doi: 10.1016/j.talanta.2014.07.053. [PMID: 25281069]
  • Marcin Protasiewicz, Karol Początek, Rafał Poręba, Arkadiusz Derkacz, Maciej Podgórski, Katarzyna Gosławska, Anna Szymańska-Chabowska, Grzegorz Mazur, Andrzej Mysiak, Adam Witkowski. Comparison of the renal hyperemic effects of papaverine and dopamine in patients with renal artery stenosis. Journal of the American Society of Hypertension : JASH. 2015 Jan; 9(1):9-14. doi: 10.1016/j.jash.2014.10.004. [PMID: 25533109]
  • L S Babinets', Iu V Droniak, K O Pliashko, A I Babinets'. [Efficiency of etiologic correction of concomitant ascaridosis in the complex treatment of chronic pancreatitis]. Likars'ka sprava. 2014 Nov; ?(11):116-8. doi: NULL. [PMID: 25528847]
  • Szende Vancea, Zsolt Gáll, Gabriella Donáth-Nagy, Réka Borka-Balás. Rapid LC-MS/MS method for determination of drotaverine in a bioequivalence study. Journal of pharmaceutical and biomedical analysis. 2014 Sep; 98(?):417-23. doi: 10.1016/j.jpba.2014.06.029. [PMID: 25005892]
  • Sally Adel, Nermeen Adel ElKasabgy. Design of innovated lipid-based floating beads loaded with an antispasmodic drug: in-vitro and in-vivo evaluation. Journal of liposome research. 2014 Jun; 24(2):136-49. doi: 10.3109/08982104.2013.857355. [PMID: 24236529]
  • Jae Hoon Kim, Hyeong-Joong Yi, Yong Ko, Young-Soo Kim, Dong-Won Kim, Jae-Min Kim. Effectiveness of papaverine cisternal irrigation for cerebral vasospasm after aneurysmal subarachnoid hemorrhage and measurement of biomarkers. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 2014 May; 35(5):715-22. doi: 10.1007/s10072-013-1589-0. [PMID: 24297765]
  • Jinda Fan, Xiang Zhang, Junfeng Li, Hongjun Jin, Prashanth K Padakanti, Lynne A Jones, Hubert P Flores, Yi Su, Joel S Perlmutter, Zhude Tu. Radiosyntheses and in vivo evaluation of carbon-11 PET tracers for PDE10A in the brain of rodent and nonhuman primate. Bioorganic & medicinal chemistry. 2014 May; 22(9):2648-54. doi: 10.1016/j.bmc.2014.03.028. [PMID: 24721831]
  • Alireza Ahmadzadeh. Papaverine increases human serum albumin glycation. Journal of biological physics. 2014 Jan; 40(1):97-107. doi: 10.1007/s10867-013-9337-5. [PMID: 24414229]
  • Eman Y Gohar, Sahar M El-gowilly, Hanan M El-Gowelli, Maha A El-Demellawy, Mahmoud M El-Mas. PI3K/Akt-independent NOS/HO activation accounts for the facilitatory effect of nicotine on acetylcholine renal vasodilations: modulation by ovarian hormones. PloS one. 2014; 9(4):e95079. doi: 10.1371/journal.pone.0095079. [PMID: 24733557]
  • N Hadiji, R Benbouzid, J G Previnaire, C Leblond, R Mieusset, M Enjalbert, J M Soler. [Evaluation of the management of erectile and ejaculatory dysfunction in a series of 90 patients with spinal cord injuries]. Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie. 2013 Dec; 23(17):1489-93. doi: 10.1016/j.purol.2013.08.316. [PMID: 24286550]
  • Stephen G Carter, Zhen Zhu, Gyula Varadi, Aristidis Veves, Jim E Riviere. Vasomodulation influences on the transdermal delivery of Ibuprofen. Journal of pharmaceutical sciences. 2013 Nov; 102(11):4072-8. doi: 10.1002/jps.23719. [PMID: 23996466]
  • Arndt-Holger Kiessling, Deniss Romasku, Andres Beiras-Fernandez, Nerea Ferreirós, Sandra Labocha, Anton Moritz, Ardawan Julian Rastan. Pharmacokinetics of intraluminally administered serum papaverine for spasm prophylaxis of the internal mammary artery. The heart surgery forum. 2013 Oct; 16(5):E266-70. doi: 10.1532/hsf98.2013201. [PMID: 24217241]
  • Krisztina Takács-Novák, Vera Szőke, Gergely Völgyi, Péter Horváth, Rita Ambrus, Piroska Szabó-Révész. Biorelevant solubility of poorly soluble drugs: rivaroxaban, furosemide, papaverine and niflumic acid. Journal of pharmaceutical and biomedical analysis. 2013 Sep; 83(?):279-85. doi: 10.1016/j.jpba.2013.05.011. [PMID: 23770783]
  • Martin Marszalek, Herbert Meixl, Claudia Pitzler, Daniela Unger, Michael Rauchenwald, Klaus Jeschke, Stephan Madersbacher. Periarterial papaverine improves early postoperative renal function after retroperitoneoscopic partial nephrectomy. World journal of urology. 2013 Aug; 31(4):829-33. doi: 10.1007/s00345-011-0712-1. [PMID: 21681524]
  • Albert Giralt, Ana Saavedra, Olga Carretón, Helena Arumí, Shiraz Tyebji, Jordi Alberch, Esther Pérez-Navarro. PDE10 inhibition increases GluA1 and CREB phosphorylation and improves spatial and recognition memories in a Huntington's disease mouse model. Hippocampus. 2013 Aug; 23(8):684-95. doi: 10.1002/hipo.22128. [PMID: 23576401]
  • D Daems, G Van Camp, M Fernandez, Y Guisez, E Prinsen, L J Nagels. Use of potentiometric detection in (ultra) high performance liquid chromatography and modelling with adsorption/desorption binding kinetics. Analytica chimica acta. 2013 May; 777(?):25-31. doi: 10.1016/j.aca.2013.03.031. [PMID: 23622961]
  • J F Polanski, O L Cruz. Evaluation of antioxidant treatment in presbyacusis: prospective, placebo-controlled, double-blind, randomised trial. The Journal of laryngology and otology. 2013 Feb; 127(2):134-41. doi: 10.1017/s0022215112003118. [PMID: 23318104]
  • Sumya Pathak, Deepika Lakhwani, Parul Gupta, Brij Kishore Mishra, Sudhir Shukla, Mehar Hasan Asif, Prabodh Kumar Trivedi. Comparative transcriptome analysis using high papaverine mutant of Papaver somniferum reveals pathway and uncharacterized steps of papaverine biosynthesis. PloS one. 2013; 8(5):e65622. doi: 10.1371/journal.pone.0065622. [PMID: 23738019]
  • Jillian M Hagel, Guillaume A W Beaudoin, Elena Fossati, Andrew Ekins, Vincent J J Martin, Peter J Facchini. Characterization of a flavoprotein oxidase from opium poppy catalyzing the final steps in sanguinarine and papaverine biosynthesis. The Journal of biological chemistry. 2012 Dec; 287(51):42972-83. doi: 10.1074/jbc.m112.420414. [PMID: 23118227]
  • Naomi Osakabe, Masahiro Shibata. Ingestion of cocoa ameliorates endothelial dysfunction in mesentery arterioles induced by high fat diet in rats: an in vivo intravital microscopy study. Life sciences. 2012 Dec; 91(23-24):1196-200. doi: 10.1016/j.lfs.2012.08.031. [PMID: 22982348]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Isabel Desgagné-Penix, Peter J Facchini. Systematic silencing of benzylisoquinoline alkaloid biosynthetic genes reveals the major route to papaverine in opium poppy. The Plant journal : for cell and molecular biology. 2012 Oct; 72(2):331-44. doi: 10.1111/j.1365-313x.2012.05084.x. [PMID: 22725256]
  • Prasad P Dahivelkar, Suvarna I Bhoir, Sanjay B Bari, Sanjay J Surana, Ashok M Bhagwat. Simultaneous determination of diclofenac potassium and drotaverine hydrochloride in human plasma using reversed-phase high-performance liquid chromatography. Journal of chromatographic science. 2012 Sep; 50(8):694-701. doi: 10.1093/chromsci/bms026. [PMID: 22573800]
  • Abdul Jabbar Shah, Anwarul Hassan Gilani. The calcium channel blocking and phosphodiesterase inhibitory activities of the extract of Andropogon muricatus explains its medicinal use in airways disorders. Phytotherapy research : PTR. 2012 Aug; 26(8):1256-8. doi: 10.1002/ptr.3687. [PMID: 22170850]
  • Ramona Steri, Janosch Achenbach, Dieter Steinhilber, Manfred Schubert-Zsilavecz, Ewgenij Proschak. Investigation of imatinib and other approved drugs as starting points for antidiabetic drug discovery with FXR modulating activity. Biochemical pharmacology. 2012 Jun; 83(12):1674-81. doi: 10.1016/j.bcp.2012.02.027. [PMID: 22414727]
  • Jonas Engelbertz, Matthias Lechtenberg, Lena Studt, Andreas Hensel, Eugen J Verspohl. Bioassay-guided fractionation of a thymol-deprived hydrophilic thyme extract and its antispasmodic effect. Journal of ethnopharmacology. 2012 Jun; 141(3):848-53. doi: 10.1016/j.jep.2012.03.025. [PMID: 22465593]
  • Munasib Khan, Arif-ullah Khan, Najeeb-ur-Rehman, Anwarul-Hassan Gilani. Pharmacological explanation for the medicinal use of Juniperus excelsa in hyperactive gastrointestinal and respiratory disorders. Journal of natural medicines. 2012 Apr; 66(2):292-301. doi: 10.1007/s11418-011-0605-z. [PMID: 22134420]
  • Daniela Küllenberg, Lenka A Taylor, Michael Schneider, Ulrich Massing. Health effects of dietary phospholipids. Lipids in health and disease. 2012 Jan; 11(?):3. doi: 10.1186/1476-511x-11-3. [PMID: 22221489]
  • N N Pshenkina. [Influence of Perftoran nanoemulsion on blood plasma concentrations of lipophilic drugs]. Eksperimental'naia i klinicheskaia farmakologiia. 2012; 75(2):30-4. doi: NULL. [PMID: 22550857]
  • Takahiro Horinouchi, Tsunaki Higa, Hiroyuki Aoyagi, Tadashi Nishiya, Koji Terada, Soichi Miwa. Adenylate cyclase/cAMP/protein kinase A signaling pathway inhibits endothelin type A receptor-operated Ca²⁺ entry mediated via transient receptor potential canonical 6 channels. The Journal of pharmacology and experimental therapeutics. 2012 Jan; 340(1):143-51. doi: 10.1124/jpet.111.187500. [PMID: 22001259]
  • F-P Chuang, M Lakin, S-T Wu, T-L Cha, G-H Sun, D K Montague. Experience with intracavernous injection in the treatment of erectile dysfunction after radical prostatectomy: dose considerations. International journal of impotence research. 2011 Jul; 23(4):146-50. doi: 10.1038/ijir.2011.21. [PMID: 21654813]
  • Suzana Brankovic, Dusanka Kitic, Mirjana Radenkovic, Slavimir Veljkovic, Teodora Jankovic, Katarina Savikin, Gordana Zdunic. Spasmolytic activity of the ethanol extract of Sideritis raeseri spp. raeseri Boiss. & Heldr. on the isolated rat ileum contractions. Journal of medicinal food. 2011 May; 14(5):495-8. doi: 10.1089/jmf.2010.0036. [PMID: 21480795]
  • Y E Ersoy, F Ayan, S Himmetoglu. Trace element levels in ischemia-reperfusion injury after left colonic anastomosis in rats and effects of papaverine and pentoxiphylline on vascular endothelial growth factor in anastomosis healing. Acta gastro-enterologica Belgica. 2011 Mar; 74(1):22-7. doi: . [PMID: 21563650]
  • P Agretti, A Dimida, G De Marco, E Ferrarini, J C Rodrìguez Gonzàlez, F Santini, P Vitti, A Pinchera, M Tonacchera. Study of potential inhibitors of thyroid iodide uptake by using CHO cells stably expressing the human sodium/iodide symporter (hNIS) protein. Journal of endocrinological investigation. 2011 Mar; 34(3):170-4. doi: 10.1007/bf03347061. [PMID: 20479570]
  • J V Hill, G Findon, R J Appelhoff, Z H Endre. Renal autoregulation and passive pressure-flow relationships in diabetes and hypertension. American journal of physiology. Renal physiology. 2010 Oct; 299(4):F837-44. doi: 10.1152/ajprenal.00727.2009. [PMID: 20660017]
  • Abdul Jabbar Shah, Anwarul-Hassan Gilani. Bronchodilatory effect of Acorus calamus (Linn.) is mediated through multiple pathways. Journal of ethnopharmacology. 2010 Sep; 131(2):471-7. doi: 10.1016/j.jep.2010.07.024. [PMID: 20643200]
  • Xu Han, Marc Lamshöft, Nadja Grobe, Xuan Ren, Anthony J Fist, Toni M Kutchan, Michael Spiteller, Meinhart H Zenk. The biosynthesis of papaverine proceeds via (S)-reticuline. Phytochemistry. 2010 Aug; 71(11-12):1305-12. doi: 10.1016/j.phytochem.2010.04.022. [PMID: 20494383]
  • Yanzong Yang, Yiqing Yang, Bo Liang, Jinqiu Liu, Jun Li, Morten Grunnet, Søren-Peter Olesen, Hanne B Rasmussen, Patrick T Ellinor, Lianjun Gao, Xiaoping Lin, Li Li, Lei Wang, Junjie Xiao, Yi Liu, Ying Liu, Shulong Zhang, Dandan Liang, Luying Peng, Thomas Jespersen, Yi-Han Chen. Identification of a Kir3.4 mutation in congenital long QT syndrome. American journal of human genetics. 2010 Jun; 86(6):872-80. doi: 10.1016/j.ajhg.2010.04.017. [PMID: 20560207]
  • Bodil Ohlsson, Eva Ekblad, Béla Veress, Agneta Montgomery, Sabina Janciauskiene. Antibodies against gonadotropin-releasing hormone (GnRH) and destruction of enteric neurons in 3 patients suffering from gastrointestinal dysfunction. BMC gastroenterology. 2010 May; 10(?):48. doi: 10.1186/1471-230x-10-48. [PMID: 20487533]
  • Ping Gu, Ying Ding, Dezhu Sun, Taijun Hang, Wenying Liu, Li Ding. Quantification of henatinib maleate, a novel potent inhibitor of VEGF receptors, in rat plasma by LC-MS/MS. Biomedical chromatography : BMC. 2010 Apr; 24(4):420-5. doi: 10.1002/bmc.1308. [PMID: 19662624]
  • Roman N Rodionov, Hayan Dayoub, Cynthia M Lynch, Katina M Wilson, Jeff W Stevens, Daryl J Murry, Masumi Kimoto, Erland Arning, Teodoro Bottiglieri, John P Cooke, Gary L Baumbach, Frank M Faraci, Steven R Lentz. Overexpression of dimethylarginine dimethylaminohydrolase protects against cerebral vascular effects of hyperhomocysteinemia. Circulation research. 2010 Feb; 106(3):551-8. doi: 10.1161/circresaha.109.200360. [PMID: 20019334]
  • Navneet Singla, Suresh N Mathuriya, Sandeep Mohindra, Alok A Umredkar, Sachin Adhikari, Sunil K Gupta, Vivek Gupta. Severe hypotension with intracisternal application of papaverine after clipping of an intracranial aneurysm. Surgical neurology. 2009 Dec; 72(6):770-1. doi: 10.1016/j.surneu.2009.04.011. [PMID: 19604547]
  • Silke Pienkny, Wolfgang Brandt, Jürgen Schmidt, Robert Kramell, Jörg Ziegler. Functional characterization of a novel benzylisoquinoline O-methyltransferase suggests its involvement in papaverine biosynthesis in opium poppy (Papaver somniferum L). The Plant journal : for cell and molecular biology. 2009 Oct; 60(1):56-67. doi: 10.1111/j.1365-313x.2009.03937.x. [PMID: 19500305]
  • Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance. Journal of medicinal chemistry. 2009 Aug; 52(15):4844-52. doi: 10.1021/jm900403j. [PMID: 19445515]
  • S I M Zayed, Y M Issa. Cathodic adsorptive stripping voltammetry of drotaverine hydrochloride and its determination in tablets and human urine by differential pulse voltammetry. Bioelectrochemistry (Amsterdam, Netherlands). 2009 Apr; 75(1):9-12. doi: 10.1016/j.bioelechem.2008.11.008. [PMID: 19138886]
  • Hong Wan, Madeleine Ahman, Anders G Holmén. Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Journal of medicinal chemistry. 2009 Mar; 52(6):1693-700. doi: 10.1021/jm801441s. [PMID: 19256501]
  • Igor L Khalif, Eamonn M M Quigley, P A Makarchuk, O V Golovenko, L F Podmarenkova, Y A Dzhanayev. Interactions between symptoms and motor and visceral sensory responses of irritable bowel syndrome patients to spasmolytics (antispasmodics). Journal of gastrointestinal and liver diseases : JGLD. 2009 Mar; 18(1):17-22. doi: ". [PMID: 19337628]
  • Anwar H Gilani, Abdul J Shah, Amina Zubair, Sana Khalid, Jawad Kiani, Amir Ahmed, Munawwer Rasheed, Viqar U Ahmad. Chemical composition and mechanisms underlying the spasmolytic and bronchodilatory properties of the essential oil of Nepeta cataria L. Journal of ethnopharmacology. 2009 Jan; 121(3):405-11. doi: 10.1016/j.jep.2008.11.004. [PMID: 19041706]
  • Zhi-hong Peng, Wei Song, Feng-mei Han, Yong Chen. In vivo and in vitro study of papaverine and its major metabolites. Yao xue xue bao = Acta pharmaceutica Sinica. 2009 Jan; 44(1):95-100. doi: ". [PMID: 19350830]
  • Paul P Bertrand, Xiaoya Hu, John Mach, Rebecca L Bertrand. Serotonin (5-HT) release and uptake measured by real-time electrochemical techniques in the rat ileum. American journal of physiology. Gastrointestinal and liver physiology. 2008 Dec; 295(6):G1228-36. doi: 10.1152/ajpgi.90375.2008. [PMID: 18927211]
  • Jonathan A Kopechek, Todd M Abruzzo, Boyu Wang, Stephen M Chrzanowski, Denise A B Smith, Patrick H Kee, Shaoling Huang, Joel H Collier, David D McPherson, Christy K Holland. Ultrasound-mediated release of hydrophilic and lipophilic agents from echogenic liposomes. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine. 2008 Nov; 27(11):1597-606. doi: 10.7863/jum.2008.27.11.1597. [PMID: 18946099]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • Kazi Mirajul Hoque, Linxi Chen, George P H Leung, Chung-Ming Tse. A purine-selective nucleobase/nucleoside transporter in PK15NTD cells. American journal of physiology. Regulatory, integrative and comparative physiology. 2008 Jun; 294(6):R1988-95. doi: 10.1152/ajpregu.00016.2008. [PMID: 18417653]
  • Nimrod Snir, Boaz Moskovitz, Ofer Nativ, David Margel, Uri Sandovski, Jacqueline Sulkes, Pinchas M Livne, David A Lifshitz. Papaverine hydrochloride for the treatment of renal colic: an old drug revisited. A prospective, randomized study. The Journal of urology. 2008 Apr; 179(4):1411-4. doi: 10.1016/j.juro.2007.11.053. [PMID: 18289563]
  • Patrick H Kee, Todd A Abruzzo, Denise A B Smith, Jonathan A Kopechek, Boyu Wang, Shaoling L Huang, Robert C MacDonald, Christy K Holland, David D McPherson. Synthesis, acoustic stability, and pharmacologic activities of papaverine-loaded echogenic liposomes for ultrasound controlled drug delivery. Journal of liposome research. 2008; 18(4):263-77. doi: 10.1080/08982100802354558. [PMID: 18720194]