Moxifloxacin (BioDeep_00000002548)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


7-[(4aS,7aS)-octahydro-1H-pyrrolo[3,4-b]pyridin-6-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

化学式: C21H24FN3O4 (401.1751)
中文名称: 1-环丙基-7-(2,8-二氮杂双环[4.3.0]壬烷-8-基)-6-氟-8-甲氧基-4-氧代喹啉-3-甲酸, 莫西沙星
谱图信息: 最多检出来源 Homo sapiens(blood) 43.3%

分子结构信息

SMILES: COC1=C2C(=CC(=C1N3CC4CCCNC4C3)F)C(=O)C(=CN2C5CC5)C(=O)O
InChI: InChI=1S/C21H24FN3O4/c1-29-20-17-13(19(26)14(21(27)28)9-25(17)12-4-5-12)7-15(22)18(20)24-8-11-3-2-6-23-16(11)10-24/h7,9,11-12,16,23H,2-6,8,10H2,1H3,(H,27,28)

描述信息

Moxifloxacin is only found in individuals that have used or taken this drug. It is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment.The bactericidal action of moxifloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV. DNA gyrase is an essential enzyme that is involved in the replication, transcription and repair of bacterial DNA. Topoisomerase IV is an enzyme known to play a key role in the partitioning of the chromosomal DNA during bacterial cell division.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01M - Quinolone antibacterials > J01MA - Fluoroquinolones
D000970 - Antineoplastic Agents > D059003 - Topoisomerase Inhibitors > D059005 - Topoisomerase II Inhibitors
S - Sensory organs > S01 - Ophthalmologicals > S01A - Antiinfectives > S01AE - Fluoroquinolones
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D024841 - Fluoroquinolones
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C254 - Anti-Infective Agent > C258 - Antibiotic > C795 - Quinolone Antibiotic
D004791 - Enzyme Inhibitors
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

16 个代谢物同义名

7-[(4aS,7aS)-octahydro-1H-pyrrolo[3,4-b]pyridin-6-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-((4as,7as)-octahydro-6H-pyrrolo(3,4-b)pyridin-6-yl)-4-oxo-3-quinolinecarboxylic acid; 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-((4as,7as)-octahydro-6H-pyrrolo(3,4-b)pyridin-6-yl)-4-oxo-3-quinolinecarboxylate; 1-cyclopropyl-6-fluoro-8-methoxy-7-(octahydro-6h-pyrrolo[3,4-b]pyridin-6-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-Cyclopropyl--7-(2,8-diazabicyclo(4.3.0)non-8-yl)-6-fluoro-8-methoxy-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; 1-cyclopropyl-7-(2,8-diazabicyclo[4.3.0]non-8-yl)-6-fluoro-8-methoxy-4-oxo-quinoline-3-carboxylic acid; Moxifloxacin hydrochloride; Moxifloxacin; BAY 12-8039; Octegra; Proflox; Avelox; Actira; Avalox; Izilox; Moxifloxacin



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ABCB1, ALB, CACNA1C, CASP3, CAT, NFKB1, VEGFA
Peripheral membrane protein 2 CYP1B1, GORASP1
Endoplasmic reticulum membrane 3 CD4, CYP1B1, MOXD1
Nucleus 4 ALB, CASP3, NFKB1, VEGFA
cytosol 5 ALB, CASP3, CAT, GPT, NFKB1
dendrite 1 CACNA1C
centrosome 1 ALB
nucleoplasm 2 CASP3, NFKB1
Cell membrane 5 ABCB1, CACNA1C, CD4, KCNH2, TNF
Cytoplasmic side 1 GORASP1
Multi-pass membrane protein 4 ABCB1, ATP4A, CACNA1C, KCNH2
Golgi apparatus membrane 1 GORASP1
cell surface 5 ABCB1, KCNH2, TNF, TNR, VEGFA
glutamatergic synapse 2 CASP3, TNR
Golgi apparatus 3 ALB, GORASP1, VEGFA
Golgi membrane 2 GORASP1, INS
neuronal cell body 2 CASP3, TNF
plasma membrane 6 ABCB1, ATP4A, CACNA1C, CD4, KCNH2, TNF
Membrane 7 ABCB1, ATP4A, CACNA1C, CAT, CYP1B1, KCNH2, VEGFA
apical plasma membrane 2 ABCB1, ATP4A
extracellular exosome 4 ABCB1, ALB, CAT, GPT
endoplasmic reticulum 2 ALB, VEGFA
extracellular space 10 ALB, ATP4A, CRP, CXCL8, IL6, INS, MOXD1, TNF, TNR, VEGFA
perinuclear region of cytoplasm 1 KCNH2
Schaffer collateral - CA1 synapse 1 TNR
adherens junction 1 VEGFA
mitochondrion 3 CAT, CYP1B1, NFKB1
protein-containing complex 2 ALB, CAT
intracellular membrane-bounded organelle 2 CAT, CYP1B1
Microsome membrane 1 CYP1B1
postsynaptic density 2 CACNA1C, CASP3
Single-pass type I membrane protein 2 CD4, MOXD1
Secreted 6 ALB, CRP, CXCL8, IL6, INS, VEGFA
extracellular region 10 ALB, CAT, CRP, CXCL8, IL6, INS, NFKB1, TNF, TNR, VEGFA
mitochondrial matrix 1 CAT
anchoring junction 1 ALB
transcription regulator complex 1 NFKB1
external side of plasma membrane 2 CD4, TNF
Secreted, extracellular space, extracellular matrix 2 TNR, VEGFA
T-tubule 1 CACNA1C
perikaryon 1 CACNA1C
Z disc 1 CACNA1C
Early endosome 1 CD4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 2 ABCB1, ATP4A
Cell membrane, sarcolemma 1 CACNA1C
Membrane raft 3 CD4, TNF, TNR
focal adhesion 1 CAT
cis-Golgi network 1 GORASP1
extracellular matrix 1 VEGFA
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 TNR
secretory granule 1 VEGFA
ciliary basal body 1 ALB
chromatin 1 NFKB1
phagocytic cup 1 TNF
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
endosome lumen 1 INS
monoatomic ion channel complex 2 CACNA1C, KCNH2
Cell projection, dendrite 1 CACNA1C
Cell membrane, sarcolemma, T-tubule 1 CACNA1C
inward rectifier potassium channel complex 1 KCNH2
voltage-gated potassium channel complex 1 KCNH2
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 3 CAT, INS, NFKB1
secretory granule membrane 1 MOXD1
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 ALB, CD4, IL6, INS
platelet alpha granule lumen 2 ALB, VEGFA
voltage-gated calcium channel complex 1 CACNA1C
specific granule lumen 1 NFKB1
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 GORASP1, INS
postsynaptic density membrane 1 CACNA1C
perineuronal net 1 TNR
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
clathrin-coated endocytic vesicle membrane 1 CD4
external side of apical plasma membrane 1 ABCB1
death-inducing signaling complex 1 CASP3
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 1 CD4
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 1 NFKB1
NF-kappaB p50/p65 complex 1 NFKB1
potassium:proton exchanging ATPase complex 1 ATP4A
tenascin complex 1 TNR
ciliary transition fiber 1 ALB
L-type voltage-gated calcium channel complex 1 CACNA1C
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Yuanqin Du, Jingjing Huang, Yaobin Nong, Ruixi Zhong, Ronghuo Zhu, Wenxuan Song, Hongna Huang, Qinwen Tan, Jian Xu, Xiyu Xiao, Juhong Jia. A case of ascetic fluid Mycobacterium aubagnense infection in a patient with severe peritoneal effusion. BMC infectious diseases. 2023 Feb; 23(1):84. doi: 10.1186/s12879-023-08041-1. [PMID: 36750816]
  • Alicja Chrzanowska, Dagmara Kurpios-Piec, Barbara Żyżyńska-Granica, Ewelina Kiernozek-Kalińska, Wen Xin Lay, Andrzej K Ciechanowicz, Marta Struga. Anticancer activity and metabolic alteration in colon and prostate cancer cells by novel moxifloxacin conjugates with fatty acids. European journal of pharmacology. 2023 Feb; 940(?):175481. doi: 10.1016/j.ejphar.2022.175481. [PMID: 36566005]
  • Haiyan Sun, Xinlou Chai, Guangxun Xu, Shuangying Wei. The Formation and Drug Resistance Mechanism of Biofilm for Streptococcus pneumoniae Infection in Severe Respiratory Patients. Cellular and molecular biology (Noisy-le-Grand, France). 2023 Jan; 69(1):75-80. doi: 10.14715/cmb/2022.69.1.13. [PMID: 37213152]
  • Iurii Mochalov, Maryna Kryvtsova, Andrij Chobey, Mariya Kulynych. Identification of Pathogenic Microflora and Its Sensitivity to Antibiotics in Cases of the Odontogenic Purulent Periostitis and Abscesses in the Oral Cavity. Prague medical report. 2023; 124(1):16-32. doi: 10.14712/23362936.2023.2. [PMID: 36763828]
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  • Xiaocui Wu, Guangkun Tan, Jinghui Yang, Yinjuan Guo, Chengchen Huang, Wei Sha, Fangyou Yu. Prediction of Mycobacterium tuberculosis drug resistance by nucleotide MALDI-TOF-MS. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2022 Aug; 121(?):47-54. doi: 10.1016/j.ijid.2022.04.061. [PMID: 35523300]
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  • Salma Luaiby Dahash, Salah Burhan Al-Windy, Azhar Hatif Al-Kuraishi, Nawar Raad Hussien, Marwa Salih Al-Niemi, Hayder Mutter Al-Kuraishy. Ellagic acid-rich Pomegranate extracts synergizes moxifloxacin against methicillin resistance Staphylococcus aureus (MRSA). JPMA. The Journal of the Pakistan Medical Association. 2021 Dec; 71(Suppl 8)(12):S88-S92. doi: ". [PMID: 35130226]
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  • Ramesh Boinpally, Brian McNamee, Li Yao, Matthew Butler, Danielle McGeeney, Lisa Borbridge, Antonia Periclou. A Single Supratherapeutic Dose of Atogepant Does Not Affect Cardiac Repolarization in Healthy Adults: Results From a Randomized, Single-Dose, Phase 1 Crossover Trial. Clinical pharmacology in drug development. 2021 09; 10(9):1099-1107. doi: 10.1002/cpdd.940. [PMID: 33942560]
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  • Tingyu Yan, Zhongxu Ma, Jingjing Liu, Na Yin, Shizhen Lei, Xinxin Zhang, Xuedong Li, Yu Zhang, Jun Kong. Thermoresponsive GenisteinNLC-dexamethasone-moxifloxacin multi drug delivery system in lens capsule bag to prevent complications after cataract surgery. Scientific reports. 2021 01; 11(1):181. doi: 10.1038/s41598-020-80476-x. [PMID: 33420301]
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