Carprofen (BioDeep_00000002532)

human metabolite blood metabolite Chemicals and Drugs Volatile Flavor Compounds

代谢物信息卡片

(+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid

化学式: C15H12ClNO2 (273.0556522)
中文名称: 卡洛芬
谱图信息: 最多检出来源 Homo sapiens(blood) 1.15%

分子结构信息

SMILES: CC(C(=O)O)c1ccc2c(c1)[nH]c1ccc(Cl)cc12
InChI: InChI=1S/C15H12ClNO2/c1-8(15(18)19)9-2-4-11-12-7-10(16)3-5-13(12)17-14(11)6-9/h2-8,17H,1H3,(H,18,19)

描述信息

Carprofen is a non-steroidal anti-inflammatory drug (NSAID) that is used by veterinarians as a supportive treatment for the relief of arthritic symptoms in geriatric dogs. Carprofen was previously used in human medicine for over 10 years (1985-1995). It was generally well tolerated, with the majority of adverse effects being mild, such as gastro-intestinal pain and nausea, similar to those recorded with aspirin and other non-steroidal anti-inflammatory drugs. It is no longer marketed for human usage, after being withdrawn on commercial grounds. [Wikipedia]
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D011838 - Radiation-Sensitizing Agents > D017319 - Photosensitizing Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
D003879 - Dermatologic Agents
Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC50s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively.

同义名列表

30 个代谢物同义名

(+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid; (+-)-6-Chloro-alpha-methylcarbazole-2-acetic acid; 6-Chloro-alpha-methyl-9H-carbazole-2-acetic acid; (+-)-6-Chloro-alpha-methylcarbazole-2-acetate; (+-)-6-Chloro-α-methylcarbazole-2-acetic acid; (+-)-6-Chloro-a-methylcarbazole-2-acetic acid; (+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoate; 6-Chloro-a-methyl-9H-carbazole-2-acetic acid; 2-(6-Chloro-9H-carbazol-2-yl)-propionic acid; 6-Chloro-α-methyl-9H-carbazole-2-acetic acid; 6-Chloro-alpha-methylcarbazole-2-acetic acid; 6-Chloro-alpha-methyl-9H-carbazole-2-acetate; 2-(6-Chloro-9H-carbazol-2-yl)propanoic acid; (+-)-6-Chloro-α-methylcarbazole-2-acetate; (+-)-6-Chloro-a-methylcarbazole-2-acetate; 6-Chloro-a-methyl-9H-carbazole-2-acetate; 6-Chloro-α-methyl-9H-carbazole-2-acetate; 2-(6-Chloro-9H-carbazol-2-yl)-propionate; (+-)-Isomer OF carprofen; (S)-Isomer OF carprofen; (R)-Isomer OF carprofen; Carprofen, (+-)-isomer; Carprofen, (S)-isomer; Carprofen, (R)-isomer; Carprofenum; Carprofeno; Carprofene; carprofen; Rimadyl; Carprofen

数据库引用编号

17 个数据库交叉引用编号

ChEBI: CHEBI:364453
KEGG: C18364
KEGGdrug: D03410
KEGGdrug: D70911
PubChem: 2581
HMDB: HMDB0014959
Metlin: METLIN44246
DrugBank: DB00821
ChEMBL: CHEMBL1316
Wikipedia: Carprofen
chemspider: 2483
CAS: 53716-49-7
CAS: 52263-47-5
PMhub: MS000003416
PubChem: 124489038
medchemexpress: HY-B1227
KNApSAcK: 364453

分类词条

Carbazoles

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 - Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Busra Aslan Akyol, Cengiz Gokbulut. The effect of intravenous lipid emulsion (ILE) on the pharmacokinetic/toxicokinetic dispositions of ivermectin and carprofen in rabbits. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Sep; ?(?):. doi: 10.1007/s00210-023-02738-5. [PMID: 37768375]
Miranda Buseman, April E Blong, Rebecca A L Walton. Successful management of severe carprofen toxicity with manual therapeutic plasma exchange in a dog. Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001). 2022 Sep; 32(5):675-679. doi: 10.1111/vec.13203. [PMID: 35527394]
Florea Dumitrascu, Ana-Maria Udrea, Mino R Caira, Diana Camelia Nuta, Carmen Limban, Mariana Carmen Chifiriuc, Marcela Popa, Coralia Bleotu, Anamaria Hanganu, Denisa Dumitrescu, Speranta Avram. In Silico and Experimental Investigation of the Biological Potential of Some Recently Developed Carprofen Derivatives. Molecules (Basel, Switzerland). 2022 Apr; 27(9):. doi: 10.3390/molecules27092722. [PMID: 35566083]
Desiree Ferrari, Sandra Lundgren, Johanna Holmberg, Anna Edner, Carl Ekstrand, Görel Nyman, Ulf Bondesson, Ragnvi Hagman. Concentration of carprofen in the milk of lactating bitches after cesarean section and during inflammatory conditions. Theriogenology. 2022 Mar; 181(?):59-68. doi: 10.1016/j.theriogenology.2022.01.016. [PMID: 35063922]
Lon V Kendall, Alexandrea L Bailey, Benjamin Singh, Whitney McGee. Toxic Effects of High-dose Meloxicam and Carprofen on Female CD1 Mice. Journal of the American Association for Laboratory Animal Science : JAALAS. 2022 01; 61(1):75-80. doi: 10.30802/aalas-jaalas-21-000071. [PMID: 34920791]
Cristhian Rene Vargas Estrada, Bruna Fernanda Firmo, Daniele Belchior Vela, Marjury Cristina Maronezi, Ricardo Andrés Ramirez Uscategui, Beatriz Gasser, Marcus Antônio Rossi Feliciano, Letícia Pavan, Luiz Paulo Nogueira Aires, Gabriela Piovan Lima, Andrigo Barboza De Nardi. Ultrasonographic assessment of renal perfusion in bitches with mammary carcinoma treated with long-term carprofen. Scientific reports. 2021 12; 11(1):23277. doi: 10.1038/s41598-021-02781-3. [PMID: 34857853]
A Parra-Coca, A Boix-Montañés, A C Calpena-Campmany, H Colom. In vivo pharmacokinetic evaluation of carprofen delivery from intra-articular nanoparticles in rabbits: A population modelling approach. Research in veterinary science. 2021 Jul; 137(?):235-242. doi: 10.1016/j.rvsc.2021.05.012. [PMID: 34049110]
Erdinc Turk, Ibrahim Ozan Tekeli, Orhan Corum, Duygu Durna Corum, Fatma Ceren Kirgiz, Gul Cetin, Dilek Arslan Atessahin, Kamil Uney. Pharmacokinetics of meloxicam, carprofen, and tolfenamic acid after intramuscular and oral administration in Japanese quails (Coturnix coturnix japonica). Journal of veterinary pharmacology and therapeutics. 2021 May; 44(3):388-396. doi: 10.1111/jvp.12972. [PMID: 33846990]
Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
Maša Bošnjak, Mojca Kržan, Urša Lampreht Tratar, Jožica Dolenc, Maja Čemažar, Alenka Seliškar. Pharmacokinetics of carprofen in anaesthetized pigs: a preliminary study. Veterinary anaesthesia and analgesia. 2021 Jan; 48(1):35-41. doi: 10.1016/j.vaa.2020.09.006. [PMID: 33303396]
T H Morris, S W Paine, P W Zahra, E C Li, S A Colgan, S L Karamatic. Pharmacokinetics of carprofen and firocoxib for medication control in racing greyhounds. Australian veterinary journal. 2020 Dec; 98(12):578-585. doi: 10.1111/avj.13014. [PMID: 32875570]
Susan M Jones, Ann Gaier, Hiroko Enomoto, Patricia Ishii, Rachel Pilla, Josh Price, Jan Suchodolski, Joerg M Steiner, Mark G Papich, Kristen Messenger, M Katherine Tolbert. The effect of combined carprofen and omeprazole administration on gastrointestinal permeability and inflammation in dogs. Journal of veterinary internal medicine. 2020 Sep; 34(5):1886-1893. doi: 10.1111/jvim.15897. [PMID: 32893926]
Kavitha Kongara, Nick Cave, Karin Weidgraaf, Venkata Sayoji Rao Dukkipati. Effect of non-steroidal anti-inflammatory drugs on glomerular filtration rate and urinary N-acetyl-β-D-glucosaminidase activity in cats after dental surgery. Veterinary anaesthesia and analgesia. 2020 Sep; 47(5):631-636. doi: 10.1016/j.vaa.2020.04.014. [PMID: 32792267]
Steven C Budsberg, Stephanie A Kleine, Megan M Norton, Gabriella S Sandberg, Mark G Papich. Comparison of the effects on lameness of orally administered acetaminophen-codeine and carprofen in dogs with experimentally induced synovitis. American journal of veterinary research. 2020 Aug; 81(8):627-634. doi: 10.2460/ajvr.81.8.627. [PMID: 32701001]
Kate S Farrell, Jamie M Burkitt-Creedon, Laura G Osborne, Erin A Gibson, Anna M Massie. Gastrointestinal obstruction secondary to activated charcoal granule impaction in a dog. Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001). 2020 Jul; 30(4):461-466. doi: 10.1111/vec.12980. [PMID: 32583603]
Aleix Gimeno, Júlia Mestres-Truyol, María José Ojeda-Montes, Guillem Macip, Bryan Saldivar-Espinoza, Adrià Cereto-Massagué, Gerard Pujadas, Santiago Garcia-Vallvé. Prediction of Novel Inhibitors of the Main Protease (M-pro) of SARS-CoV-2 through Consensus Docking and Drug Reposition. International journal of molecular sciences. 2020 May; 21(11):. doi: 10.3390/ijms21113793. [PMID: 32471205]
Jutarat Apakupakul, Panpicha Sattasathuchana, Phongsak Chanloinapha, Naris Thengchaisri. Optimization of a rapid one-step platelet-rich plasma preparation method using syringe centrifugation with and without carprofen. BMC veterinary research. 2020 May; 16(1):124. doi: 10.1186/s12917-020-02350-2. [PMID: 32375782]
M Locatelli, A Tartaglia, F D'Ambrosio, P Ramundo, H I Ulusoy, K G Furton, A Kabir. Biofluid sampler: A new gateway for mail-in-analysis of whole blood samples. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2020 Apr; 1143(?):122055. doi: 10.1016/j.jchromb.2020.122055. [PMID: 32172173]
Meghan E Fick, Kristen M Messenger, Alessio Vigani. Efficacy of a single session in-series hemoperfusion and hemodialysis in the management of carprofen overdose in two dogs. Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001). 2020 Mar; 30(2):226-231. doi: 10.1111/vec.12931. [PMID: 32128985]
Daniel Limones-Herrero, Fabrizio Palumbo, Victoria Vendrell-Criado, Inmaculada Andreu, Emilio Lence, Concepción González-Bello, Miguel A Miranda, M Consuelo Jiménez. Investigation of metabolite-protein interactions by transient absorption spectroscopy and in silico methods. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2020 Feb; 226(?):117652. doi: 10.1016/j.saa.2019.117652. [PMID: 31654902]
Ismael Hernández-Avalos, Alexander Valverde, José Antonio Ibancovichi-Camarillo, Pedro Sánchez-Aparicio, Sergio Recillas-Morales, Jorge Osorio-Avalos, Desiderio Rodríguez-Velázquez, Agatha Elisa Miranda-Cortés. Clinical evaluation of postoperative analgesia, cardiorespiratory parameters and changes in liver and renal function tests of paracetamol compared to meloxicam and carprofen in dogs undergoing ovariohysterectomy. PloS one. 2020; 15(2):e0223697. doi: 10.1371/journal.pone.0223697. [PMID: 32059002]
Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
Veena Krishnan, David Booker, Gabrielle Cunningham, Jeevan Kumar Jadapalli, Vasundhara Kain, Amanda B Pullen, Ganesh V Halade. Pretreatment of carprofen impaired initiation of inflammatory- and overlapping resolution response and promoted cardiorenal syndrome in heart failure. Life sciences. 2019 Feb; 218(?):224-232. doi: 10.1016/j.lfs.2018.12.048. [PMID: 30597172]
Evgeniy Salnikov, Binia Drung, Gabin Fabre, Anna Itkin, Michal Otyepka, Norbert A Dencher, Boris Schmidt, Thomas Hauß, Patrick Trouillas, Burkhard Bechinger. Lipid bilayer position and orientation of novel carprofens, modulators of γ-secretase in Alzheimer's disease. Biochimica et biophysica acta. Biomembranes. 2018 11; 1860(11):2224-2233. doi: 10.1016/j.bbamem.2018.09.003. [PMID: 30409518]
M Leiberich, R Krebber, M Hewetson, J Marais, V Naidoo. A study of the pharmacokinetics and thromboxane inhibitory activity of a single intramuscular dose of carprofen as a means to establish its potential use as an analgesic drug in white rhinoceros. Journal of veterinary pharmacology and therapeutics. 2018 Aug; 41(4):605-613. doi: 10.1111/jvp.12508. [PMID: 29691872]
Astrid B Kjaergaard, Jennifer L Davis, Mark J Acierno. Treatment of carprofen overdose with therapeutic plasma exchange in a dog. Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001). 2018 Jul; 28(4):356-360. doi: 10.1111/vec.12729. [PMID: 29898245]
V Naidoo, M A Taggart, N Duncan, K Wolter, J Chipangura, R E Green, T H Galligan. The use of toxicokinetics and exposure studies to show that carprofen in cattle tissue could lead to secondary toxicity and death in wild vultures. Chemosphere. 2018 Jan; 190(?):80-89. doi: 10.1016/j.chemosphere.2017.08.167. [PMID: 28985539]
Vanessa L Oliver, Stephanie Athavale, Katherine E Simon, Lon V Kendall, Jean A Nemzek, Jennifer L Lofgren. Evaluation of Pain Assessment Techniques and Analgesia Efficacy in a Female Guinea Pig (Cavia porcellus) Model of Surgical Pain. Journal of the American Association for Laboratory Animal Science : JAALAS. 2017 Jul; 56(4):425-435. doi: NULL. [PMID: 28724492]
Andrea Barbarossa, Julie Rambaldi, Massimo Giunti, Anna Zaghini, Marco Cunto, Daniele Zambelli, Simond Valgimigli, Francesco Santoro, Noemi Romagnoli. Pharmacokinetics of buprenorphine following constant rate infusion for postoperative analgesia in dogs undergoing ovariectomy. Veterinary anaesthesia and analgesia. 2017 May; 44(3):435-443. doi: 10.1016/j.vaa.2016.05.010. [PMID: 28416162]
I Schulze, E M Poos, H Meyer, A K List, S B R Kaestner, J Rehage. Effects of preoperative carprofen on cardio-respiratory, hormonal and metabolic stress response in calves during umbilical surgery under isoflurane inhalation anaesthesia. Veterinary journal (London, England : 1997). 2016 Oct; 216(?):18-24. doi: 10.1016/j.tvjl.2016.06.009. [PMID: 27687921]
Thanikul Srithunyarat, Odd V Höglund, Ragnvi Hagman, Ulf Olsson, Mats Stridsberg, Anne-Sofie Lagerstedt, Ann Pettersson. Catestatin, vasostatin, cortisol, temperature, heart rate, respiratory rate, scores of the short form of the Glasgow composite measure pain scale and visual analog scale for stress and pain behavior in dogs before and after ovariohysterectomy. BMC research notes. 2016 Aug; 9(?):381. doi: 10.1186/s13104-016-2193-1. [PMID: 27484122]
Mingjie Tang, Yanjie Guo, Youshui Gao, Chao Tang, Xiaoqian Dang, Zubin Zhou, Yuqiang Sun, Kunzheng Wang. Albumin's Influence on Carprofen Enantiomers-Hymecromone Interaction. Chirality. 2016 Mar; 28(3):226-9. doi: 10.1002/chir.22562. [PMID: 26708612]
M L Stock, L A Barth, N K Van Engen, S T Millman, R Gehring, C Wang, E A Voris, L W Wulf, Léa Labeur, W H Hsu, J F Coetzee. Impact of carprofen administration on stress and nociception responses of calves to cautery dehorning. Journal of animal science. 2016 Feb; 94(2):542-55. doi: 10.2527/jas.2015-9510. [PMID: 27065124]
K M Messenger, J A Wofford, M G Papich. Carprofen pharmacokinetics in plasma and in control and inflamed canine tissue fluid using in vivo ultrafiltration. Journal of veterinary pharmacology and therapeutics. 2016 Feb; 39(1):32-9. doi: 10.1111/jvp.12233. [PMID: 25958925]
Travis L Seymour, Sean C Adams, Stephen A Felt, Katechan Jampachaisri, David C Yeomans, Cholawat Pacharinsak. Postoperative Analgesia Due to Sustained-Release Buprenorphine, Sustained-Release Meloxicam, and Carprofen Gel in a Model of Incisional Pain in Rats (Rattus norvegicus). Journal of the American Association for Laboratory Animal Science : JAALAS. 2016; 55(3):300-5. doi: . [PMID: 27177563]
Amy M Koenigshof, Matthew W Beal, Robert H Poppenga, L Ari Jutkowitz. Effect of sorbitol, single, and multidose activated charcoal administration on carprofen absorption following experimental overdose in dogs. Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001). 2015 Sep; 25(5):606-10. doi: 10.1111/vec.12305. [PMID: 25891141]
D Marini, J Pippia, I G Colditz, G Hinch, J C Petherick, C Lee. Randomised trial of the bioavailability and efficacy of orally administered flunixin, carprofen and ketoprofen in a pain model in sheep. Australian veterinary journal. 2015 Aug; 93(8):265-70. doi: 10.1111/avj.12351. [PMID: 26220318]
M Vailati Riboni, S Meier, N V Priest, C R Burke, J K Kay, S McDougall, M D Mitchell, C G Walker, M Crookenden, A Heiser, J R Roche, J J Loor. Adipose and liver gene expression profiles in response to treatment with a nonsteroidal antiinflammatory drug after calving in grazing dairy cows. Journal of dairy science. 2015 May; 98(5):3079-85. doi: 10.3168/jds.2014-8579. [PMID: 25771063]
K S Kalchofner Guerrero, A Schwarz, R Wuhrmann, S Feldmann, S Hartnack, R Bettschart-Wolfensberger. Comparison of a new metamizole formulation and carprofen for extended post-operative analgesia in dogs undergoing ovariohysterectomy. Veterinary journal (London, England : 1997). 2015 Apr; 204(1):99-104. doi: 10.1016/j.tvjl.2015.01.028. [PMID: 25744803]
Zhong-Ze Fang, Haina Wang, Yun-Feng Cao, Dong-Xue Sun, Li-Xuan Wang, Mo Hong, Ting Huang, Jian-Xing Chen, Jia Zeng. Enantioselective inhibition of carprofen towards UDP-glucuronosyltransferase (UGT) 2B7. Chirality. 2015 Mar; 27(3):189-93. doi: 10.1002/chir.22412. [PMID: 25502512]
Tamsyn Fourie, Duncan Cromarty, Neil Duncan, Kerri Wolter, Vinny Naidoo. The Safety and Pharmacokinetics of Carprofen, Flunixin and Phenylbutazone in the Cape Vulture (Gyps coprotheres) following Oral Exposure. PloS one. 2015; 10(10):e0141419. doi: 10.1371/journal.pone.0141419. [PMID: 26512724]
Michèle Sidler, Nathalie Fouché, Ingmar Meth, Friedrich von Hahn, Brigitte von Rechenberg, Peter W Kronen. Preliminary study on carprofen concentration measurements after transcutaneous treatment with Vetdrop® in a microfracture joint defect model in sheep. BMC veterinary research. 2014 Dec; 10(?):268. doi: 10.1186/s12917-014-0268-6. [PMID: 25488522]
Lisa Y Pang, Sally A Argyle, Ayako Kamida, Katherine O'Neill Morrison, David J Argyle. The long-acting COX-2 inhibitor mavacoxib (Trocoxil™) has anti-proliferative and pro-apoptotic effects on canine cancer cell lines and cancer stem cells in vitro. BMC veterinary research. 2014 Sep; 10(?):184. doi: 10.1186/s12917-014-0184-9. [PMID: 25190452]
Gerald A Hish, Jose A Diaz, Angela E Hawley, Daniel D Myers, Patrick A Lester. Effects of analgesic use on inflammation and hematology in a murine model of venous thrombosis. Journal of the American Association for Laboratory Animal Science : JAALAS. 2014 Sep; 53(5):485-93. doi: . [PMID: 25255071]
Lon V Kendall, Ryan J Hansen, Kathryn Dorsey, Sooah Kang, Paul J Lunghofer, Daniel L Gustafson. Pharmacokinetics of sustained-release analgesics in mice. Journal of the American Association for Laboratory Animal Science : JAALAS. 2014 Sep; 53(5):478-84. doi: . [PMID: 25255070]
Ulrika Falkenö, Harold William Tvedten, Camilla Spångberg. What is your diagnosis? Urine sediment changes in a dog with hemorrhagic shock and disseminated intravascular coagulation after pyometra surgery. Veterinary clinical pathology. 2014 Sep; 43(3):463-4. doi: 10.1111/vcp.12158. [PMID: 24931400]
S Meier, N V Priest, C R Burke, J K Kay, S McDougall, M D Mitchell, C G Walker, A Heiser, J J Loor, J R Roche. Treatment with a nonsteroidal antiinflammatory drug after calving did not improve milk production, health, or reproduction parameters in pasture-grazed dairy cows. Journal of dairy science. 2014 May; 97(5):2932-43. doi: 10.3168/jds.2013-7838. [PMID: 24630655]
Magdalena Szweda, Józef Szarek, Krystyna Dublan, Tomasz Męcik-Kronenberg, Zdzisław Kiełbowicz, Marcin Bigoszewski. Effect of mucoprotective plant-derived therapies on damage to colonic mucosa caused by carprofen and robenacoxib administered to healthy dogs for 21 days. The veterinary quarterly. 2014; 34(4):185-93. doi: 10.1080/01652176.2014.968939. [PMID: 25330194]
Cavit Kum, Huseyin Voyvoda, Selim Sekkin, Umit Karademir, Tugrul Tarimcilar. Effects of carprofen and meloxicam on C-reactive protein, ceruloplasmin, and fibrinogen concentrations in dogs undergoing ovariohysterectomy. American journal of veterinary research. 2013 Oct; 74(10):1267-73. doi: 10.2460/ajvr.74.10.1267. [PMID: 24066910]
Rae G Hutchins, Kristen M Messenger, Shelly L Vaden. Suspected carprofen toxicosis caused by coprophagia in a dog. Journal of the American Veterinary Medical Association. 2013 Sep; 243(5):709-11. doi: 10.2460/javma.243.5.709. [PMID: 23971852]
Joelle C Ingrao, Ron Johnson, Elizabeth Tor, Yu Gu, Marcus Litman, Patricia V Turner. Aqueous stability and oral pharmacokinetics of meloxicam and carprofen in male C57BL/6 mice. Journal of the American Association for Laboratory Animal Science : JAALAS. 2013 Sep; 52(5):553-9. doi: NULL. [PMID: 24041210]
C Brentnall, Z Cheng, Q A McKellar, P Lees. Influence of oxytetracycline on carprofen pharmacodynamics and pharmacokinetics in calves. Journal of veterinary pharmacology and therapeutics. 2013 Aug; 36(4):320-8. doi: 10.1111/jvp.12000. [PMID: 22913421]
A Torres, J Chagas E Silva, P Diniz, L Lopes-da-Costa. Evaluation of treatments with hCG and carprofen at embryo transfer in a demi-embryo and recipient virgin heifer model. Animal : an international journal of animal bioscience. 2013 Aug; 7(8):1317-22. doi: 10.1017/s1751731113000426. [PMID: 23506998]
N V Priest, S McDougall, C R Burke, J R Roche, M Mitchell, K L McLeod, S L Greenwood, S Meier. The responsiveness of subclinical endometritis to a nonsteroidal antiinflammatory drug in pasture-grazed dairy cows. Journal of dairy science. 2013 Jul; 96(7):4323-32. doi: 10.3168/jds.2012-6266. [PMID: 23660148]
C Brentnall, Z Cheng, Q A McKellar, P Lees. Pharmacokinetic-pharmacodynamic integration and modelling of oxytetracycline administered alone and in combination with carprofen in calves. Research in veterinary science. 2013 Jun; 94(3):687-94. doi: 10.1016/j.rvsc.2013.01.012. [PMID: 23415880]
Claire Brentnall, Zhangrui Cheng, Quintin A McKellar, Peter Lees. Potency and selectivity of carprofen enantiomers for inhibition of bovine cyclooxygenase in whole blood assays. Research in veterinary science. 2012 Dec; 93(3):1387-92. doi: 10.1016/j.rvsc.2012.05.002. [PMID: 22703724]
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Kathryn K Surdyk, Dawn L Sloan, Scott A Brown. Renal effects of carprofen and etodolac in euvolemic and volume-depleted dogs. American journal of veterinary research. 2012 Sep; 73(9):1485-90. doi: 10.2460/ajvr.73.9.1485. [PMID: 22924732]
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