Acetyl-CoA (BioDeep_00000002522)

 

Secondary id: BioDeep_00000419552

natural product human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


{[(2R,3S,4R,5R)-2-({[({[(3R)-3-[(2-{[2-(acetylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropoxy](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]oxy}methyl)-5-(6-amino-9H-purin-9-yl)-4-hydroxyoxolan-3-yl]oxy}phosphonic acid

化学式: C23H38N7O17P3S (809.1257688000001)
中文名称: 乙酰辅酶 A 钠盐, 乙酰辅酶A, 乙酰辅酶A
谱图信息: 最多检出来源 Macaca mulatta(otcml) 0.33%

分子结构信息

SMILES: CC(=O)SCCNC(=O)CCNC(=O)C(C(C)(C)COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)O)O
InChI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)

描述信息

The main function of coenzyme A is to carry acyl groups (such as the acetyl group) or thioesters. Acetyl-CoA is an important molecule itself. It is the precursor to HMG CoA, which is a vital component in cholesterol and ketone synthesis. (wikipedia). acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.
The main function of coenzyme A is to carry acyl groups (such as the acetyl group) or thioesters. Acetyl-CoA is an important molecule itself. It is the precursor to HMG CoA, which is a vital component in cholesterol and ketone synthesis. (wikipedia)

同义名列表

26 个代谢物同义名

{[(2R,3S,4R,5R)-2-({[({[(3R)-3-[(2-{[2-(acetylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropoxy](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]oxy}methyl)-5-(6-amino-9H-purin-9-yl)-4-hydroxyoxolan-3-yl]oxy}phosphonic acid; 12-Hydroxy Taurolithocholic Acid Sulfate Disodium Salt; Acetyl Coenzyme A trisodium; Acetyl coenzyme A (C2:0); S-Acetate coenzyme A; S-Acetyl coenzyme A; Acetyl-S-coenzyme A; S-Acetyl-coenzyme A; coenzyme A, Acetyl; Acetyl-coenzyme A; Acetyl coenzyme A; Acetyl coenzyme-A; Acetylcoenzyme-A; Acetylcoenzyme A; Ac-S-coenzyme A; Ac-coenzyme A; S-Acetate CoA; S-Acetyl-CoA; Acetyl-S-CoA; CoA, Acetyl; Acetyl-CoA; Acetyl CoA; Ac-S-CoA; Ac-CoA; AcCoA; Acetyl-CoA



数据库引用编号

41 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(6)

BioCyc(24)

PlantCyc(0)

代谢反应

1898 个相关的代谢反应过程信息。

Reactome(205)

BioCyc(57)

WikiPathways(32)

Plant Reactome(1026)

INOH(15)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(563)

PharmGKB(0)

5 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shubha Sharma, Seema Chaurasia, Sandeep Dinday, Gaurav Srivastava, Anamika Singh, Chandan Singh Chanotiya, Sumit Ghosh. High-level biosynthesis of enantiopure germacrene D in yeast. Applied microbiology and biotechnology. 2024 Dec; 108(1):50. doi: 10.1007/s00253-023-12885-7. [PMID: 38183482]
  • Juhong Wang, Yannan Yang, Fei Shao, Ying Meng, Dong Guo, Jie He, Zhimin Lu. Acetate reprogrammes tumour metabolism and promotes PD-L1 expression and immune evasion by upregulating c-Myc. Nature metabolism. 2024 May; 6(5):914-932. doi: 10.1038/s42255-024-01037-4. [PMID: 38702440]
  • Xue Bai, Shuling Wang, Qin Zhang, Yuhan Hu, Jiawei Zhou, Lianhui Men, Dengyu Li, Jing Ma, Qiuhui Wei, Mengdie Xu, Xiaopu Yin, Tianyuan Hu. Reprogramming the Metabolism of Yeast for High-Level Production of Miltiradiene. Journal of agricultural and food chemistry. 2024 Apr; 72(15):8704-8714. doi: 10.1021/acs.jafc.4c01203. [PMID: 38572931]
  • Qiaoqiao Guo, Jingtong Su, Yuling Liao, Yin Yu, Lizhen Luo, Xiaoshan Weng, Wenbin Zhang, Zhe Hu, Haihong Wang, Gwyn A Beattie, Jincheng Ma. An atypical 3-ketoacyl ACP synthase III required for acyl homoserine lactone synthesis in Pseudomonas syringae pv. syringae B728a. Applied and environmental microbiology. 2024 Mar; 90(3):e0225623. doi: 10.1128/aem.02256-23. [PMID: 38415624]
  • Yang Ning, Mengsu Liu, Ziyun Ru, Weizhu Zeng, Song Liu, Jingwen Zhou. Efficient synthesis of squalene by cytoplasmic-peroxisomal engineering and regulating lipid metabolism in Yarrowia lipolytica. Bioresource technology. 2024 Mar; 395(?):130379. doi: 10.1016/j.biortech.2024.130379. [PMID: 38281547]
  • Yue Yu, Feng Zhao, Yaping Yue, Yu Zhao, Dao-Xiu Zhou. Lysine acetylation of histone acetyltransferase adaptor protein ADA2 is a mechanism of metabolic control of chromatin modification in plants. Nature plants. 2024 03; 10(3):439-452. doi: 10.1038/s41477-024-01623-0. [PMID: 38326652]
  • Kyung Hee Jung, Sujin Lee, Han Sun Kim, Jin-Mo Kim, Yun Ji Lee, Min Seok Park, Myeong-Seong Seo, Misu Lee, Mijin Yun, Sunghyouk Park, Soon-Sun Hong. Acetyl-CoA synthetase 2 contributes to a better prognosis for liver cancer by switching acetate-glucose metabolism. Experimental & molecular medicine. 2024 Mar; 56(3):721-733. doi: 10.1038/s12276-024-01185-3. [PMID: 38528124]
  • Shuhua Zhao, Qingqiang Wang, Xiaohong Zhang, Boyi Ma, Yuan Shi, Yadong Yin, Weina Kong, Wei Zhang, Jibin Li, Hong Yang. MARCH5-mediated downregulation of ACC2 promotes fatty acid oxidation and tumor progression in ovarian cancer. Free radical biology & medicine. 2024 Feb; 212(?):464-476. doi: 10.1016/j.freeradbiomed.2024.01.004. [PMID: 38211832]
  • Lan Wang, Hongmei Yuan, Wenwen Li, Peishuo Yan, Mengxia Zhao, Zhongzheng Li, Huabin Zhao, Shenghui Wang, Ruyan Wan, Yajun Li, Juntang Yang, Xin Pan, Ivan Rosas, Guoying Yu. ACSS3 regulates the metabolic homeostasis of epithelial cells and alleviates pulmonary fibrosis. Biochimica et biophysica acta. Molecular basis of disease. 2024 Feb; 1870(2):166960. doi: 10.1016/j.bbadis.2023.166960. [PMID: 37979225]
  • Yongshuo Ma, Yi Shang, Gregory Stephanopoulos. Engineering peroxisomal biosynthetic pathways for maximization of triterpene production in Yarrowia lipolytica. Proceedings of the National Academy of Sciences of the United States of America. 2024 Jan; 121(5):e2314798121. doi: 10.1073/pnas.2314798121. [PMID: 38261612]
  • Shaofang Xie, Lei Yuan, Yue Sui, Shan Feng, Hengle Li, Xu Li. NME4 mediates metabolic reprogramming and promotes nonalcoholic fatty liver disease progression. EMBO reports. 2024 Jan; 25(1):378-403. doi: 10.1038/s44319-023-00012-6. [PMID: 38177901]
  • João Vitor Alcantara da Silva, Jessica Ispada, Ricardo Perecin Nociti, Aldcejam Martins da Fonseca Junior, Camila Bruna De Lima, Erika Cristina Dos Santos, Marcos Roberto Chiaratti, Marcella Pecora Milazzotto. The central role of pyruvate metabolism on the epigenetic maturation and transcriptional profile of bovine oocytes. Reproduction (Cambridge, England). 2024 Jan; ?(?):. doi: 10.1530/rep-23-0181. [PMID: 38271822]
  • Kenneth K Y Ting, Pei Yu, Mudia Iyayi, Riley Dow, Sharon J Hyduk, Eric Floro, Hisham Ibrahim, Saraf Karim, Chanele K Polenz, Daniel A Winer, Minna Woo, Jonathan Rocheleau, Jenny Jongstra-Bilen, Myron I Cybulsky. Oxidized Low-Density Lipoprotein Accumulation in Macrophages Impairs Lipopolysaccharide-Induced Activation of AKT2, ATP Citrate Lyase, Acetyl-Coenzyme A Production, and Inflammatory Gene H3K27 Acetylation. ImmunoHorizons. 2024 Jan; 8(1):57-73. doi: 10.4049/immunohorizons.2300101. [PMID: 38193847]
  • Shiyong Li, Chaodong Song, Hongyan Zhang, Yan Qin, Mingguo Jiang, Naikun Shen. Comparative Transcriptome Analysis Reveals the Molecular Mechanisms of Acetic Acid Reduction by Adding NaHSO3 in Actinobacillus succinogenes GXAS137. Polish journal of microbiology. 2023 Dec; 72(4):399-411. doi: 10.33073/pjm-2023-036. [PMID: 38000010]
  • Guo Chen, Banghe Bao, Yang Cheng, Minxiu Tian, Jiyu Song, Liduan Zheng, Qiangsong Tong. Acetyl-CoA metabolism as a therapeutic target for cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Dec; 168(?):115741. doi: 10.1016/j.biopha.2023.115741. [PMID: 37864899]
  • Yuan Yao, Jiaming Shi, Chunlai Zhang, Wei Gao, Ning Huang, Yaobei Liu, Weiwen Yan, Yingguang Han, Wenjuan Zhou, Liang Kong. Pyruvate dehydrogenase kinase 1 protects against neuronal injury and memory loss in mouse models of diabetes. Cell death & disease. 2023 11; 14(11):722. doi: 10.1038/s41419-023-06249-2. [PMID: 37935660]
  • C Megan Young, Laurent Beziaud, Pierre Dessen, Angela Madurga Alonso, Albert Santamaria-Martínez, Joerg Huelsken. Metabolic dependencies of metastasis-initiating cells in female breast cancer. Nature communications. 2023 11; 14(1):7076. doi: 10.1038/s41467-023-42748-8. [PMID: 37925484]
  • Pranesha Prabhakaran, Mohamed Yusuf Mohamed Nazir, Roypim Thananusak, Aidil Abdul Hamid, Wanwipa Vongsangnak, Yuanda Song. Uncovering global lipid accumulation routes towards docosahexaenoic acid (DHA) production in Aurantiochytrium sp. SW1 using integrative proteomic analysis. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2023 11; 1868(11):159381. doi: 10.1016/j.bbalip.2023.159381. [PMID: 37625782]
  • Lin Tan, Sara A Martinez, Philip L Lorenzi, Anja Karlstaedt. Quantitative Analysis of Acetyl-CoA, Malonyl-CoA, and Succinyl-CoA in Myocytes. Journal of the American Society for Mass Spectrometry. 2023 Oct; ?(?):. doi: 10.1021/jasms.3c00278. [PMID: 37812744]
  • Wenjun Wang, Junyang Tan, Xiaomin Liu, Wenqi Guo, Mengmeng Li, Xinjie Liu, Yanyan Liu, Wenyu Dai, Liubing Hu, Yimin Wang, Qiuxia Lu, Wen Xing Lee, Hong-Wen Tang, Qinghua Zhou. Cytoplasmic Endonuclease G promotes nonalcoholic fatty liver disease via mTORC2-AKT-ACLY and endoplasmic reticulum stress. Nature communications. 2023 Oct; 14(1):6201. doi: 10.1038/s41467-023-41757-x. [PMID: 37794041]
  • Vishant Tomar, Erik H A Rikkerink, Janghoon Song, Svetla Sofkova-Bobcheva, Vincent G M Bus. Structure-Function Characterisation of Eop1 Effectors from the Erwinia-Pantoea Clade Reveals They May Acetylate Their Defence Target through a Catalytic Dyad. International journal of molecular sciences. 2023 Sep; 24(19):. doi: 10.3390/ijms241914664. [PMID: 37834112]
  • Jian Lu, Xue-Qi Li, Pei-Pei Chen, Jia-Xiu Zhang, Liang Li, Gui-Hua Wang, Xiao-Qi Liu, Chun-Ming Jiang, Kun-Ling Ma. Acetyl-CoA synthetase 2 promotes diabetic renal tubular injury in mice by rewiring fatty acid metabolism through SIRT1/ChREBP pathway. Acta pharmacologica Sinica. 2023 Sep; ?(?):. doi: 10.1038/s41401-023-01160-0. [PMID: 37770579]
  • Bin Zhang, Yang Xu, Jinyan Liu, Chongming Wu, Xiaohong Zhao, Lidong Zhou, Yong Xie. Oral Intake of Inosine 5'-Monophosphate in Mice Promotes the Absorption of Exogenous Fatty Acids and Their Conversion into Triglycerides though Enhancing the Phosphorylation of Adenosine 5'-Monophosphate-Activated Protein Kinase in the Liver, Leading to Lipohyperplasia. International journal of molecular sciences. 2023 Sep; 24(19):. doi: 10.3390/ijms241914588. [PMID: 37834038]
  • Dina Baier, Theresa Mendrina, Beatrix Schoenhacker-Alte, Christine Pirker, Thomas Mohr, Mate Rusz, Benedict Regner, Martin Schaier, Nicolas Sgarioto, Noël J-M Raynal, Karin Nowikovsky, Wolfgang M Schmidt, Petra Heffeter, Samuel M Meier-Menches, Gunda Koellensperger, Bernhard K Keppler, Walter Berger. The Lipid Metabolism as Target and Modulator of BOLD-100 Anticancer Activity: Crosstalk with Histone Acetylation. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023 Sep; ?(?):e2301939. doi: 10.1002/advs.202301939. [PMID: 37752764]
  • Zhicheng Huang, Qing Wang, Irshad Ali Khan, Yan Li, Jing Wang, Jiaoyu Wang, Xiaohong Liu, Fucheng Lin, Jianping Lu. The Methylcitrate Cycle and Its Crosstalk with the Glyoxylate Cycle and Tricarboxylic Acid Cycle in Pathogenic Fungi. Molecules (Basel, Switzerland). 2023 Sep; 28(18):. doi: 10.3390/molecules28186667. [PMID: 37764443]
  • Lior Doron, Markus Sutter, Cheryl A Kerfeld. Characterization of a novel aromatic substrate-processing microcompartment in Actinobacteria. mBio. 2023 Jul; ?(?):e0121623. doi: 10.1128/mbio.01216-23. [PMID: 37462359]
  • Eric Fordjour, Chun-Li Liu, Yunpeng Hao, Isaac Sackey, Yankun Yang, Xiuxia Liu, Ye Li, Tianwei Tan, Zhonghu Bai. Engineering Escherichia coli BL21 (DE3) for high-yield production of germacrene A, a precursor of β-elemene via combinatorial metabolic engineering strategies. Biotechnology and bioengineering. 2023 Jun; ?(?):. doi: 10.1002/bit.28467. [PMID: 37309999]
  • Qiutao Xu, Yaping Yue, Biao Liu, Zhengting Chen, Xuan Ma, Jing Wang, Yu Zhao, Dao-Xiu Zhou. ACL and HAT1 form a nuclear module to acetylate histone H4K5 and promote cell proliferation. Nature communications. 2023 06; 14(1):3265. doi: 10.1038/s41467-023-39101-4. [PMID: 37277331]
  • Jiawei Wang, Qin Wang, Xiaolin Huang, Wei Hu, Shanshan Wang, Zhiguo Zhou. Phosphorus-induced greater enhancement in carbon supply and storage for oil synthesis during the crucial period made cottonseed kernel oil yield have a higher increment than protein. Plant physiology and biochemistry : PPB. 2023 May; 200(?):107781. doi: 10.1016/j.plaphy.2023.107781. [PMID: 37230024]
  • Yawen Lu, Yimeng Chen, Wenxin Hu, Meng Wang, Xiaodong Wen, Jie Yang. Inhibition of ACSS2 attenuates alcoholic liver steatosis via epigenetically regulating de novo lipogenesis. Liver international : official journal of the International Association for the Study of the Liver. 2023 May; ?(?):. doi: 10.1111/liv.15600. [PMID: 37183518]
  • Adilson Guilherme, Leslie A Rowland, Nicole Wetoska, Emmanouela Tsagkaraki, Kaltinaitis B Santos, Alexander H Bedard, Felipe Henriques, Mark Kelly, Sean Munroe, David J Pedersen, Olga R Ilkayeva, Timothy R Koves, Lauren Tauer, Meixia Pan, Xianlin Han, Jason K Kim, Christopher B Newgard, Deborah M Muoio, Michael P Czech. Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program. Cell reports. 2023 May; 42(5):112488. doi: 10.1016/j.celrep.2023.112488. [PMID: 37163372]
  • Luke T Izzo, Sophie Trefely, Christina Demetriadou, Jack M Drummond, Takuya Mizukami, Nina Kuprasertkul, Aimee T Farria, Phuong T T Nguyen, Nivitha Murali, Lauren Reich, Daniel S Kantner, Joshua Shaffer, Hayley Affronti, Alessandro Carrer, Andrew Andrews, Brian C Capell, Nathaniel W Snyder, Kathryn E Wellen. Acetylcarnitine shuttling links mitochondrial metabolism to histone acetylation and lipogenesis. Science advances. 2023 May; 9(18):eadf0115. doi: 10.1126/sciadv.adf0115. [PMID: 37134161]
  • Chenyu Hu, Zechang Xin, Xiaoyan Sun, Yang Hu, Chunfeng Zhang, Rui Yan, Yuying Wang, Min Lu, Jing Huang, Xiaojuan Du, Baocai Xing, Xiaofeng Liu. Activation of ACLY by SEC63 deploys metabolic reprogramming to facilitate hepatocellular carcinoma metastasis upon endoplasmic reticulum stress. Journal of experimental & clinical cancer research : CR. 2023 May; 42(1):108. doi: 10.1186/s13046-023-02656-7. [PMID: 37122003]
  • Dan Liu, Changsheng Dong, Fengying Wang, Wei Liu, Xing Jin, Sheng-Lan Qi, Lei Liu, Qiang Jin, Siliang Wang, Jia Wu, Congcong Wang, Jing Yang, Haibin Deng, Yuejiao Cai, Lu Yang, Jingru Qin, Chengcheng Zhang, Xi Yang, Ming-Song Wang, Guanzhen Yu, Yu-Wen Xue, Zhongqi Wang, Guang-Bo Ge, Zhenye Xu, Wen-Lian Chen. Active post-transcriptional regulation and ACLY-mediated acetyl-CoA synthesis as a pivotal target of Shuang-Huang-Sheng-Bai formula for lung adenocarcinoma treatment. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 May; 113(?):154732. doi: 10.1016/j.phymed.2023.154732. [PMID: 36933457]
  • Tobias Schwanemann, Maike Otto, Benedikt Wynands, Jan Marienhagen, Nick Wierckx. A Pseudomonas taiwanensis malonyl-CoA platform strain for polyketide synthesis. Metabolic engineering. 2023 Apr; 77(?):219-230. doi: 10.1016/j.ymben.2023.04.001. [PMID: 37031949]
  • Yu Wang, Wei Sun, Sen Yan, Zhiyuan Meng, Ming Jia, Sinuo Tian, Shiran Huang, Xiaoxuan Sun, Shihang Han, Canping Pan, Jinling Diao, Qiuxia Wang, Wentao Zhu. A new strategy to alleviate the obesity induced by endocrine disruptors-A unique lysine metabolic pathway of nanoselenium Siraitia grosvenorii to repair gut microbiota and resist obesity. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023 Mar; 175(?):113737. doi: 10.1016/j.fct.2023.113737. [PMID: 36944396]
  • Giovan N Cholico, Karina Orlowska, Russell R Fling, Warren J Sink, Nicholas A Zacharewski, Kelly A Fader, Rance Nault, Tim Zacharewski. Consequences of reprogramming acetyl-CoA metabolism by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse liver. Scientific reports. 2023 Mar; 13(1):4138. doi: 10.1038/s41598-023-31087-9. [PMID: 36914879]
  • Maki Nishii, Shoki Ito, Takashi Osanai. Citrate synthase from Cyanidioschyzon merolae exhibits high oxaloacetate and acetyl-CoA catalytic efficiency. Plant molecular biology. 2023 Mar; ?(?):. doi: 10.1007/s11103-023-01335-7. [PMID: 36884198]
  • Patricia Altea-Manzano, Ginevra Doglioni, Yawen Liu, Alejandro M Cuadros, Emma Nolan, Juan Fernández-García, Qi Wu, Mélanie Planque, Kathrin Julia Laue, Florencia Cidre-Aranaz, Xiao-Zheng Liu, Oskar Marin-Bejar, Joke Van Elsen, Ines Vermeire, Dorien Broekaert, Sofie Demeyer, Xander Spotbeen, Jakub Idkowiak, Aurélie Montagne, Margherita Demicco, H Furkan Alkan, Nick Rabas, Carla Riera-Domingo, François Richard, Tatjana Geukens, Maxim De Schepper, Sophia Leduc, Sigrid Hatse, Yentl Lambrechts, Emily Jane Kay, Sergio Lilla, Alisa Alekseenko, Vincent Geldhof, Bram Boeckx, Celia de la Calle Arregui, Giuseppe Floris, Johannes V Swinnen, Jean-Christophe Marine, Diether Lambrechts, Vicent Pelechano, Massimiliano Mazzone, Sara Zanivan, Jan Cools, Hans Wildiers, Véronique Baud, Thomas G P Grünewald, Uri Ben-David, Christine Desmedt, Ilaria Malanchi, Sarah-Maria Fendt. A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling. Nature cancer. 2023 Feb; ?(?):. doi: 10.1038/s43018-023-00513-2. [PMID: 36732635]
  • Jake Hsu, Nina Fatuzzo, Nielson Weng, Wojciech Michno, Wentao Dong, Maryline Kienle, Yuqin Dai, Anca Pasca, Monther Abu-Remaileh, Natalie Rasgon, Benedetta Bigio, Carla Nasca, Chaitan Khosla. Carnitine octanoyltransferase is important for the assimilation of exogenous acetyl-L-carnitine into acetyl-CoA in mammalian cells. The Journal of biological chemistry. 2023 02; 299(2):102848. doi: 10.1016/j.jbc.2022.102848. [PMID: 36587768]
  • Haoya Yao, Yaoqing Wang, Xiao Zhang, Ping Li, Lin Shang, Xiaocui Chen, Jia Zeng. Targeting peroxisomal fatty acid oxidation improves hepatic steatosis and insulin resistance in obese mice. The Journal of biological chemistry. 2023 02; 299(2):102845. doi: 10.1016/j.jbc.2022.102845. [PMID: 36586435]
  • Jürgen Eirich, Julia Sindlinger, Stefan Schön, Dirk Schwarzer, Iris Finkemeier. Peptide CoA conjugates for in situ proteomics profiling of acetyltransferase activities. Methods in enzymology. 2023; 684(?):209-252. doi: 10.1016/bs.mie.2022.09.005. [PMID: 37230590]
  • Weijing He, Qingguo Li, Xinxiang Li. Acetyl-CoA regulates lipid metabolism and histone acetylation modification in cancer. Biochimica et biophysica acta. Reviews on cancer. 2023 01; 1878(1):188837. doi: 10.1016/j.bbcan.2022.188837. [PMID: 36403921]
  • Youlin Wang, Hao Yang, Chloé Geerts, Alexandra Furtos, Paula Waters, Denis Cyr, Shupei Wang, Grant A Mitchell. The multiple facets of acetyl-CoA metabolism: Energetics, biosynthesis, regulation, acylation and inborn errors. Molecular genetics and metabolism. 2023 01; 138(1):106966. doi: 10.1016/j.ymgme.2022.106966. [PMID: 36528988]
  • Sijia Chen, Weidong Ye, Kendall D Clements, Ziye Zan, Weishan Zhao, Hong Zou, Guitang Wang, Shangong Wu. Bacillus licheniformis FA6 Affects Zebrafish Lipid Metabolism through Promoting Acetyl-CoA Synthesis and Inhibiting β-Oxidation. International journal of molecular sciences. 2022 Dec; 24(1):. doi: 10.3390/ijms24010673. [PMID: 36614116]
  • Lianhu Zhang, Chonglei Shan, Yifan Zhang, Wenjing Miao, Xiaoli Bing, Weigang Kuang, Zonghua Wang, Ruqiang Cui, Stefan Olsson. Transcriptome Analysis of Protein Kinase MoCK2, which Affects Acetyl-CoA Metabolism and Import of CK2-Interacting Mitochondrial Proteins into Mitochondria in the Rice Blast Fungus Magnaporthe oryzae. Microbiology spectrum. 2022 12; 10(6):e0304222. doi: 10.1128/spectrum.03042-22. [PMID: 36255296]
  • Ying-Shuang Xu, Wang Ma, Jin Li, Peng-Wei Huang, Xiao-Man Sun, He Huang. Metal cofactor regulation combined with rational genetic engineering of Schizochytrium sp. for high-yield production of squalene. Biotechnology and bioengineering. 2022 Dec; ?(?):. doi: 10.1002/bit.28311. [PMID: 36522292]
  • Ting Miao, Jinoh Kim, Ping Kang, Hideji Fujiwara, Fong-Fu Hsu, Hua Bai. Acetyl-CoA-mediated autoacetylation of fatty acid synthase as a metabolic switch of de novo lipogenesis in Drosophila. Proceedings of the National Academy of Sciences of the United States of America. 2022 12; 119(49):e2212220119. doi: 10.1073/pnas.2212220119. [PMID: 36459649]
  • Mei Zhang, Zhu Wang, Zhe Chi, Guang-Lei Liu, Zhen-Ming Chi. Metabolic engineering of Aureobasidium melanogenum 9-1 for overproduction of liamocins by enhancing supply of acetyl-CoA and ATP. Microbiological research. 2022 Dec; 265(?):127172. doi: 10.1016/j.micres.2022.127172. [PMID: 36084615]
  • Eric Soupene, Frans A Kuypers. Dual Role of ACBD6 in the Acylation Remodeling of Lipids and Proteins. Biomolecules. 2022 11; 12(12):. doi: 10.3390/biom12121726. [PMID: 36551154]
  • Jie Qi, Xianzun Xiao, Liming Ouyang, Chenghan Yang, Yingping Zhuang, Lixin Zhang. Enhancement of fatty acid degradation pathway promoted glucoamylase synthesis in Aspergillus niger. Microbial cell factories. 2022 Nov; 21(1):238. doi: 10.1186/s12934-022-01966-3. [PMID: 36376878]
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