L-Prolinamide (BioDeep_00000002487)

   


代谢物信息卡片


(S)-Pyrrolidine-2-carboxamide

化学式: C5H10N2O (114.0793)
中文名称: (S)-2-吡咯烷甲酰胺, L-脯氨酰胺, DL-脯氨酰胺
谱图信息: 最多检出来源 Homo sapiens(lipidsearch) 16.3%

分子结构信息

SMILES: C1CC(NC1)C(=O)N
InChI: InChI=1S/C5H10N2O/c6-5(8)4-2-1-3-7-4/h4,7H,1-3H2,(H2,6,8)



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 BCL2, CALCA, MTOR, MYC, PIK3C3, PIK3CA, PIN1, TP53
Peripheral membrane protein 1 MTOR
Endoplasmic reticulum membrane 2 BCL2, MTOR
Cytoplasmic vesicle, autophagosome 1 PIK3C3
Nucleus 5 BCL2, MTOR, MYC, PIN1, TP53
autophagosome 1 PIK3C3
cytosol 6 BCL2, MTOR, PIK3C3, PIK3CA, PIN1, TP53
dendrite 3 MTOR, OPRM1, PNOC
phagocytic vesicle 1 MTOR
phosphatidylinositol 3-kinase complex, class III 1 PIK3C3
centrosome 1 TP53
nucleoplasm 5 CD2, MTOR, MYC, PIN1, TP53
Cell membrane 6 CALCR, CD2, KCNH2, OPRD1, OPRL1, OPRM1
Cytoplasmic side 1 MTOR
lamellipodium 1 PIK3CA
Cell projection, axon 1 OPRM1
Multi-pass membrane protein 6 CALCR, KCNA3, KCNH2, OPRD1, OPRL1, OPRM1
Golgi apparatus membrane 1 MTOR
Synapse 2 OPRM1, PNOC
cell surface 3 CD2, KCNH2, TNR
glutamatergic synapse 4 KCNA3, PIK3C3, PIN1, TNR
Golgi apparatus 3 ATRN, CD2, OPRM1
Golgi membrane 1 MTOR
lysosomal membrane 1 MTOR
neuronal cell body 2 CALCA, PNOC
presynaptic membrane 2 KCNA3, OPRD1
Lysosome 1 MTOR
acrosomal vesicle 1 CALCR
endosome 2 OPRM1, PIK3C3
plasma membrane 10 ATRN, CALCR, CD2, KCNA3, KCNH2, OPRD1, OPRL1, OPRM1, PIK3CA, PNOC
synaptic vesicle membrane 1 OPRD1
terminal bouton 1 CALCA
Membrane 10 BCL2, CALCR, KCNA3, KCNH2, MTOR, MYC, OPRD1, OPRM1, PIK3C3, TP53
axon 3 CALCR, KCNA3, OPRM1
extracellular exosome 1 ATRN
Lysosome membrane 1 MTOR
endoplasmic reticulum 3 BCL2, OPRM1, TP53
extracellular space 4 ATRN, CALCA, CXCL8, TNR
perinuclear region of cytoplasm 3 KCNA3, KCNH2, PIK3CA
Schaffer collateral - CA1 synapse 1 TNR
intercalated disc 1 PIK3CA
mitochondrion 2 BCL2, TP53
protein-containing complex 4 BCL2, CD2, MYC, TP53
Microsome membrane 1 MTOR
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 2 ATRN, CD2
Secreted 4 CALCA, CXCL8, PNOC, TRH
extracellular region 6 CALCA, CD2, CXCL8, PNOC, TNR, TRH
cytoplasmic side of plasma membrane 1 CD2
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, MTOR
hippocampal mossy fiber to CA3 synapse 1 CALCA
[Isoform 2]: Secreted 1 ATRN
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
transcription regulator complex 1 TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 CD2
Secreted, extracellular space, extracellular matrix 1 TNR
perikaryon 1 OPRM1
cytoplasmic vesicle 1 OPRL1
nucleolus 2 MYC, TP53
midbody 2 PIK3C3, PIN1
cell-cell junction 1 CD2
postsynaptic membrane 1 KCNA3
Membrane raft 2 KCNA3, TNR
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
GABA-ergic synapse 1 PIK3C3
Peroxisome 1 PIK3C3
Nucleus, PML body 2 MTOR, TP53
PML body 2 MTOR, TP53
collagen-containing extracellular matrix 1 TNR
secretory granule 1 TRH
axoneme 1 PIK3C3
nuclear speck 1 PIN1
Late endosome 1 PIK3C3
neuron projection 3 OPRD1, OPRL1, OPRM1
ciliary basal body 1 PIN1
cilium 1 CALCR
chromatin 2 MYC, TP53
phagocytic vesicle membrane 1 PIK3C3
Nucleus, nucleolus 1 MYC
[Isoform 2]: Cell membrane 1 KCNA3
site of double-strand break 1 TP53
[Isoform 3]: Secreted 1 ATRN
nuclear envelope 2 MTOR, MYC
Endomembrane system 1 MTOR
phagophore assembly site 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type I 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type II 1 PIK3C3
monoatomic ion channel complex 1 KCNH2
Nucleus, nucleoplasm 1 MYC
Cell projection, dendrite 1 OPRM1
Nucleus speckle 1 PIN1
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
inward rectifier potassium channel complex 1 KCNH2
synaptic membrane 1 PNOC
voltage-gated potassium channel complex 2 KCNA3, KCNH2
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
axon terminus 2 OPRD1, PNOC
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
RNA polymerase II transcription repressor complex 1 MYC
postsynaptic density membrane 1 OPRD1
perineuronal net 1 TNR
presynaptic endosome 1 PIK3C3
neuronal dense core vesicle 2 CALCA, OPRD1
calyx of Held 1 KCNA3
[Isoform 1]: Nucleus 1 TP53
[Isoform 1]: Cell membrane 2 ATRN, KCNA3
dendrite membrane 1 OPRD1
Rough endoplasmic reticulum 1 MYC
postsynaptic cytosol 1 PIN1
Cytoplasmic vesicle, phagosome 1 MTOR
amylin receptor complex 3 1 CALCR
postsynaptic endosome 1 PIK3C3
Myc-Max complex 1 MYC
Autolysosome 1 PIK3C3
BAD-BCL-2 complex 1 BCL2
[Isoform 3]: Cytoplasm, perinuclear region 1 KCNA3
tenascin complex 1 TNR
amylin receptor complex 1 1 CALCR
amylin receptor complex 2 1 CALCR
[Isoform 12]: Cytoplasm 1 OPRM1
spine apparatus 1 OPRD1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
nucleoplasmic reticulum 1 MYC


文献列表

  • Jonas Schilz, Charlotte Clement, Franziska Greiner, Arne Skerra. Direct Affinity Purification of Long-Acting PASylated Proteins with Therapeutic Potential Using L-Prolinamide for Mild Elution. Angewandte Chemie (International ed. in English). 2022 06; 61(25):e202200079. doi: 10.1002/anie.202200079. [PMID: 35325504]
  • Il Hak Bae, Hee Sun Kim, Youngsu You, Chieyeon Chough, Weonu Choe, Min Kyung Seon, Seung Gi Lee, Gyochang Keum, Sung Key Jang, B Moon Kim. Novel benzidine and diaminofluorene prolinamide derivatives as potent hepatitis C virus NS5A inhibitors. European journal of medicinal chemistry. 2015 Aug; 101(?):163-78. doi: 10.1016/j.ejmech.2015.06.033. [PMID: 26134551]
  • Griet Van Zeebroeck, Beatriz Monge Bonini, Matthias Versele, Johan M Thevelein. Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor. Nature chemical biology. 2009 Jan; 5(1):45-52. doi: 10.1038/nchembio.132. [PMID: 19060912]
  • Takashi Kondo, Takahiro Nekado, Isamu Sugimoto, Kenya Ochi, Shigeyuki Takai, Atsushi Kinoshita, Akira Hatayama, Susumu Yamamoto, Kazuhito Kawabata, Hisao Nakai, Masaaki Toda. Discovery of long-acting N-(cyanomethyl)-N-alkyl-L-prolinamide inhibitors of dipeptidyl peptidase IV. Bioorganic & medicinal chemistry. 2008 Jan; 16(1):190-208. doi: 10.1016/j.bmc.2007.10.005. [PMID: 17962025]