Azinphos-ethyl (BioDeep_00000002393)

 

Secondary id: BioDeep_00001867900

human metabolite blood metabolite


代谢物信息卡片


O,O-diethyl {[(4-oxo-3,4-dihydro-1,2,3-benzotriazin-3-yl)methyl]sulfanyl}phosphonothioate

化学式: C12H16N3O3PS2 (345.0371)
中文名称: 乙基古硫磷标准溶液
谱图信息: 最多检出来源 Homo sapiens(blood) 64%

分子结构信息

SMILES: CCOP(=S)(OCC)SCN1C(=O)C2=CC=CC=C2N=N1
InChI: InChI=1S/C12H16N3O3PS2/c1-3-17-19(20,18-4-2)21-9-15-12(16)10-7-5-6-8-11(10)13-14-15/h5-8H,3-4,9H2,1-2H3



数据库引用编号

29 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 CAT, G6PD, HPGDS, PTP4A2, TYR
Peripheral membrane protein 2 ACHE, G6PD
Endoplasmic reticulum membrane 1 PNPLA6
Nucleus 2 ACHE, PTP4A2
cytosol 6 CAT, G6PD, GSR, HPGDS, PNPLA6, PTP4A2
nucleoplasm 1 HPGDS
Cell membrane 1 ACHE
Synapse 1 ACHE
cell surface 1 ACHE
Golgi apparatus 1 ACHE
neuromuscular junction 1 ACHE
Cytoplasm, cytosol 1 G6PD
Lysosome 1 TYR
plasma membrane 3 ACHE, BCHE, PTP4A2
Membrane 4 ACHE, CAT, G6PD, PNPLA6
extracellular exosome 3 CAT, G6PD, GSR
endoplasmic reticulum 1 PNPLA6
extracellular space 2 ACHE, BCHE
perinuclear region of cytoplasm 2 ACHE, TYR
mitochondrion 2 CAT, GSR
protein-containing complex 1 CAT
intracellular membrane-bounded organelle 4 CAT, G6PD, HPGDS, TYR
Single-pass type I membrane protein 1 TYR
Secreted 2 ACHE, BCHE
extracellular region 3 ACHE, BCHE, CAT
cytoplasmic side of plasma membrane 1 G6PD
mitochondrial matrix 2 CAT, GSR
Extracellular side 1 ACHE
centriolar satellite 1 G6PD
external side of plasma membrane 1 GSR
Melanosome membrane 1 TYR
Early endosome 1 PTP4A2
Golgi-associated vesicle 1 TYR
focal adhesion 1 CAT
Peroxisome 1 CAT
basement membrane 1 ACHE
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
blood microparticle 1 BCHE
Lipid-anchor, GPI-anchor 1 ACHE
Melanosome 1 TYR
side of membrane 1 ACHE
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
endoplasmic reticulum lumen 1 BCHE
Single-pass type III membrane protein 1 PNPLA6
nuclear envelope lumen 1 BCHE
synaptic cleft 1 ACHE
catalase complex 1 CAT
[Isoform H]: Cell membrane 1 ACHE


文献列表

  • R A Videira, M C Antunes-Madeira, V M Madeira. Ethylazinphos interaction with membrane lipid organization induces increase of proton permeability and impairment of mitochondrial bioenergetic functions. Toxicology and applied pharmacology. 2001 Sep; 175(3):209-16. doi: 10.1006/taap.2001.9246. [PMID: 11559019]
  • R A Videira, M C Antunes-Madeira, V M Madeira. Biophysical perturbations induced by ethylazinphos in lipid membranes. Chemistry and physics of lipids. 1999 Feb; 97(2):139-53. doi: 10.1016/s0009-3084(98)00105-4. [PMID: 10192930]
  • R A Videira, M do C Antunes-Madeira, V M Madeira. Interaction of ethylazinphos with the physical organization of model and native membranes. Biochimica et biophysica acta. 1996 May; 1281(1):65-72. doi: 10.1016/0005-2736(96)00012-0. [PMID: 8652607]
  • N Ahmad, L Guo, P Mandarakas, S Appleby, G Bugueno. Passive diffusion through polymeric membranes: a novel cleanup procedure for analysis of azinphos-methyl and azinphos-ethyl residues in fruits and vegetables. Journal of AOAC International. 1995 Nov; 78(6):1450-4. doi: . [PMID: 8664581]
  • E G Marques. Acute intoxication by azinphos-ethyl. Journal of analytical toxicology. 1990 Jul; 14(4):243-6. doi: 10.1093/jat/14.4.243. [PMID: 2395348]