Benzenebutanoic acid (BioDeep_00000002386)
Secondary id: BioDeep_00001867828
human metabolite Endogenous Chemicals and Drugs
代谢物信息卡片
4-Phenylbutyric acid, calcium salt
化学式: C10H12O2 (164.0837)
中文名称: 苯丁酸, 4-苯基丁酸
谱图信息:
最多检出来源 Homo sapiens(not specific) 2.02%
分子结构信息
SMILES: C1=CC=C(C=C1)CCCC(=O)O
InChI: InChI=1S/C10H12O2/c11-10(12)8-4-7-9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H,11,12)
描述信息
Benzenebutanoic acid (also known as 4-phenylbutyrate, or 4-PBA) is the oral form of butyrate, which is known to be a transcriptional regulator. Sodium-4-PBA has been shown to induce fetal hemoglobin, and it has been used in clinical trials for sickle cell anemia and β-thalassemia. Because gene expression profiles became more differentiated, it is in phase I trials in several different malignant disorders. The potential for therapeutic benefit in cystic fibrosis (CF) resides in an additional mechanism, involving protein folding and the ER (endoplasmic reticulum) environment (PMID 12458151). 4-PBA is a drug that was developed to treat elevated blood ammonia in urea cycle disorders, a histone deacetylase inhibitor that promotes mutation ΔF508 cystic fibrosis transmembrane conductance regulator (CFTR) trafficking (PMID 16798551).
4-phenylbutyrate (4-PBA) is known to be a transcriptional regulator, and sodium-4-PBA has been shown to induce fetal hemoglobin, and it has been used in clinical trials for sickle cell anemia and β-thalassemia Because gene expression profiles became more differentiated, it is in phase I trials in several different malignant disorders. The potential for therapeutic benefit in cystic fibrosis (CF) resides in an additional mechanism, involving protein folding and the ER environment. 4-PBA is a drug that was developed to treat elevated blood ammonia in urea cycle disorders, a histone deacetylase inhibitor that promotes mutation ΔF508 cystic fibrosis transmembrane conductance regulator (CFTR) trafficking. (PMID 12458151) [HMDB]
C471 - Enzyme Inhibitor > C1946 - Histone Deacetylase Inhibitor
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent
D000970 - Antineoplastic Agents
同义名列表
52 个代谢物同义名
4-Phenylbutyric acid, calcium salt; 4-Phenylbutyric acid, sodium salt; gamma-Phenyl-N-butyric acid; gamma-Phenylbutanoic acid; Omega-phenylbutanoic acid; gamma-Phenyl-butyric acid; Sodium 4-phenylbutanoate; gamma-Phenylbutyric acid; Omega-phenylbutyric acid; g-Phenyl-N-butyric acid; 4-Phenyl-N-butyric acid; gamma-Phenyl-N-butyrate; Γ-phenyl-N-butyric acid; Sodium 4-phenylbutyrate; 4-PHENYL-butanoIC ACID; 4-Phenylbutanoic acid; W-Phenylbutanoic acid; gamma-Phenyl-butyrate; g-Phenyl-butyric acid; Omega-phenylbutanoate; Sodium phenylbutyrate; 4-Phenyl-butyric acid; g-Phenylbutanoic acid; gamma-Phenylbutanoate; gamma-Phenylbutyrate; 4-PHENYLBUTYRIC ACID; Omega-phenylbutyrate; g-Phenylbutyric acid; Γ-phenylbutyric acid; Benzenebutanoic acid; Γ-phenyl-N-butyrate; g-Phenyl-N-butyrate; Benzenebutyric acid; 4-Phenyl-N-butyrate; 4-PHENYL-butanoate; Phenylbutyric acid; 4-Phenyl-butyrate; W-Phenylbutanoate; g-Phenylbutanoate; g-Phenyl-butyrate; 4-Phenylbutanoate; g-Phenylbutyrate; 4-Phenylbutyrate; Benzenebutanoate; Γ-phenylbutyrate; Benzenebutyrate; Phenylbutyrate; Ammonaps; Buphenyl; PBA; Benzenebutanoic acid; 4-Phenylbutyric acid
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:41500
- KEGG: C21793
- PubChem: 4775
- HMDB: HMDB0000543
- DrugBank: DB06819
- ChEMBL: CHEMBL1469
- MetaCyc: CPD-14367
- foodb: FDB022106
- chemspider: 4611
- CAS: 1262970-43-3
- CAS: 461391-24-2
- CAS: 358730-86-6
- CAS: 1821-12-1
- PMhub: MS000002499
- PubChem: 355052573
- PDB-CCD: CLT
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 9606 - Homo sapiens: -
- 1883 - Streptomyces: 10.1016/J.JIPH.2019.09.004
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Lu Liu, Jie Wu, Changlin Zhang, Tong Cao, Yongli Lu, Zhi He, Zicheng Li. Inhibition of endoplasmic reticulum stress attenuates morphine protracted abstinence-induced anxiety-like behaviors in the male mice.
Brain research.
2024 Jul; 1835(?):148930. doi:
10.1016/j.brainres.2024.148930. [PMID: 38604556] - Yuanqun Zhou, Yu Zhu, Yue Wu, Xinming Xiang, Xingnan Ouyang, Liangming Liu, Tao Li. 4-phenylbutyric acid improves sepsis-induced cardiac dysfunction by modulating amino acid metabolism and lipid metabolism via Comt/Ptgs2/Ppara.
Metabolomics : Official journal of the Metabolomic Society.
2024 Apr; 20(3):46. doi:
10.1007/s11306-024-02112-3. [PMID: 38641695] - Caroline N Rivera, Carly E Smith, Lillian V Draper, Rachel M Watne, Andrew J Wommack, Roger A Vaughan. Physiological 4-phenylbutyrate promotes mitochondrial biogenesis and metabolism in C2C12 myotubes.
Biochimie.
2024 Apr; 219(?):155-164. doi:
10.1016/j.biochi.2023.11.009. [PMID: 38008282] - Lei Wang, Daoliang Zhang, Benzheng Jiang, Hongyan Ding, Shibin Feng, Chang Zhao, Xichun Wang, Jinjie Wu. 4-Phenylbutyric Acid Attenuates Soybean Glycinin/β-Conglycinin-Induced IPEC-J2 Cells Apoptosis by Regulating the Mitochondria-Associated Endoplasmic Reticulum Membrane and NLRP-3.
Journal of agricultural and food chemistry.
2024 Mar; 72(11):5926-5934. doi:
10.1021/acs.jafc.3c09630. [PMID: 38457471] - Rui Li, Fan Li, Xuning Wang, Mingxin Bai, Hu Fu, Zhengli Yan, Xiaoping Yang, Yongfei Zhu. 4-Phenylbutyric acid may prevent mouse ovarian and uterine damage due to procymidone-induced alteration of circRNA Scar and circZc3h4 levels by controlling excessive unfolded protein response.
Pesticide biochemistry and physiology.
2023 Nov; 196(?):105631. doi:
10.1016/j.pestbp.2023.105631. [PMID: 37945263] - Bo He, Zhigang Wang, Régis Moreau. Chylomicron production is repressed by RPTOR knockdown, R-α-lipoic acid and 4-phenylbutyric acid in human enterocyte-like Caco-2 cells.
The Journal of nutritional biochemistry.
2022 10; 108(?):109087. doi:
10.1016/j.jnutbio.2022.109087. [PMID: 35691593] - Hai Jia, Tongkun Zhang, Ning Liu, Xuemeng Si, Jun Bai, Ying Yang, Zhaohui Chen, Zhenlong Wu. 4-Phenylbutyric acid alleviates 3-acetyldeoxynivalenol-induced immune cells response by inhibiting endoplasmic reticulum stress in mouse spleen.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2022 Jun; 164(?):113002. doi:
10.1016/j.fct.2022.113002. [PMID: 35413383] - Mark Sicking, Martina Živná, Pratiti Bhadra, Veronika Barešová, Andrea Tirincsi, Drazena Hadzibeganovic, Kateřina Hodaňová, Petr Vyleťal, Jana Sovová, Ivana Jedličková, Martin Jung, Thomas Bell, Volkhard Helms, Anthony J Bleyer, Stanislav Kmoch, Adolfo Cavalié, Sven Lang. Phenylbutyrate rescues the transport defect of the Sec61α mutations V67G and T185A for renin.
Life science alliance.
2022 04; 5(4):. doi:
10.26508/lsa.202101150. [PMID: 35064074] - Jing Chen, Hongbo Wu, Xudong Tang, Lei Chen. 4-Phenylbutyrate protects against rifampin-induced liver injury via regulating MRP2 ubiquitination through inhibiting endoplasmic reticulum stress.
Bioengineered.
2022 02; 13(2):2866-2877. doi:
10.1080/21655979.2021.2024970. [PMID: 35045794] - Shaimaa H Gadallah, Hala M Ghanem, Amany Abdel-Ghaffar, Fatma G Metwaly, Laila K Hanafy, Emad K Ahmed. 4-Phenylbutyric acid and rapamycin improved diabetic status in high fat diet/streptozotocin-induced type 2 diabetes through activation of autophagy.
Archives of physiology and biochemistry.
2021 Jun; 127(3):235-244. doi:
10.1080/13813455.2019.1628069. [PMID: 31215250] - Zhaoling Shi, Yue Yin, Chen Li, Hui Ding, Nan Mu, Yishi Wang, Shanshan Jin, Heng Ma, Manling Liu, Jie Zhou. Lipocalin-2-induced proliferative endoplasmic reticulum stress participates in Kawasaki disease-related pulmonary arterial abnormalities.
Science China. Life sciences.
2021 Jun; 64(6):1000-1012. doi:
10.1007/s11427-019-1772-8. [PMID: 32915407] - Wenlai He, Dezhe Qin, Balun Li, Huimin Zhang, Xuedi Cheng, Jing Sun, Jinlian Hua, Sha Peng. Immortalized canine adipose-derived mesenchymal stem cells alleviate gentamicin-induced acute kidney injury by inhibiting endoplasmic reticulum stress in mice and dogs.
Research in veterinary science.
2021 May; 136(?):39-50. doi:
10.1016/j.rvsc.2021.02.001. [PMID: 33582313] - Rulin Ma, Bei Li, Cheng Zhang, Rongrong Lei, Xiao Zhang, Chao Wang, Shun Zhang, Aiguo Wang. Roles of endoplasmic reticulum stress in 2,2',4,4'-tetrabromodiphenylether-induced thyroid cell apoptosis and autophagy.
Ecotoxicology and environmental safety.
2021 May; 214(?):112077. doi:
10.1016/j.ecoenv.2021.112077. [PMID: 33647853] - Rachida Amzal, Alice Thébaut, Martine Lapalus, Marion Almes, Brigitte Grosse, Elodie Mareux, Mauricette Collado-Hilly, Anne Davit-Spraul, Laure Bidou, Olivier Namy, Emmanuel Jacquemin, Emmanuel Gonzales. Pharmacological Premature Termination Codon Readthrough of ABCB11 in Bile Salt Export Pump Deficiency: An In Vitro Study.
Hepatology (Baltimore, Md.).
2021 04; 73(4):1449-1463. doi:
10.1002/hep.31476. [PMID: 32702170] - Shuhei Osaka, Satoshi Nakano, Tadahaya Mizuno, Yuka Hiraoka, Kei Minowa, Saeko Hirai, Ayumu Mizutani, Yusuke Sabu, Yoshiki Miura, Toshiaki Shimizu, Hiroyuki Kusuhara, Mitsuyoshi Suzuki, Hisamitsu Hayashi. A randomized trial to examine the impact of food on pharmacokinetics of 4-phenylbutyrate and change in amino acid availability after a single oral administration of sodium 4-phenylbutyrarte in healthy volunteers.
Molecular genetics and metabolism.
2021 04; 132(4):220-226. doi:
10.1016/j.ymgme.2021.02.002. [PMID: 33648834] - Amany Abdel-Ghaffar, Ghada G Elhossary, Atef M Mahmoud, Amany H M Elshazly, Olfat A Hassanin, Anisa Saleh, Sahar M Mansour, Fatma G Metwally, Laila K Hanafy, Sawsan H Karam, Neveen Darweesh, Ahmed Mostafa Ata. Effects of 4-phenylbutyric acid on the development of diabetic retinopathy in diabetic rats: regulation of endoplasmic reticulum stress-oxidative activation.
Archives of physiology and biochemistry.
2021 Mar; ?(?):1-11. doi:
10.1080/13813455.2021.1888302. [PMID: 33653182] - Tanyel Zubarioglu, Elif Dede, Humeyra Cigdem, Ertugrul Kiykim, Mehmet S Cansever, Cigdem Aktuglu-Zeybek. Impact of sodium phenylbutyrate treatment in acute management of maple syrup urine disease attacks: a single-center experience.
Journal of pediatric endocrinology & metabolism : JPEM.
2021 Jan; 34(1):121-126. doi:
10.1515/jpem-2020-0356. [PMID: 33180043] - Beatriz Delgado-Valero, Lucía de la Fuente-Chávez, Ana Romero-Miranda, María Visitación Bartolomé, Bunty Ramchandani, Fabián Islas, María Luaces, Victoria Cachofeiro, Ernesto Martínez-Martínez. Role of endoplasmic reticulum stress in renal damage after myocardial infarction.
Clinical science (London, England : 1979).
2021 01; 135(1):143-159. doi:
10.1042/cs20201137. [PMID: 33355632] - Jiyoung Lee, Shuo Geng, Song Li, Liwu Li. Single Cell RNA-Seq and Machine Learning Reveal Novel Subpopulations in Low-Grade Inflammatory Monocytes With Unique Regulatory Circuits.
Frontiers in immunology.
2021; 12(?):627036. doi:
10.3389/fimmu.2021.627036. [PMID: 33708217] - Ke Gao, Chengfei Zhang, Yihong Tian, Sajid Naeem, Yingmei Zhang, Yongmei Qi. The role of endoplasmic reticulum stress in lead (Pb)-induced mitophagy of HEK293 cells.
Toxicology and industrial health.
2020 Dec; 36(12):1002-1009. doi:
10.1177/0748233720971882. [PMID: 33169630] - Hannah Crossland, Kenneth Smith, Iskandar Idris, Bethan E Phillips, Philip J Atherton, Daniel J Wilkinson. Exploring mechanistic links between extracellular branched-chain amino acids and muscle insulin resistance: an in vitro approach.
American journal of physiology. Cell physiology.
2020 12; 319(6):C1151-C1157. doi:
10.1152/ajpcell.00377.2020. [PMID: 33026831] - Sabrina Paganoni, Eric A Macklin, Suzanne Hendrix, James D Berry, Michael A Elliott, Samuel Maiser, Chafic Karam, James B Caress, Margaret A Owegi, Adam Quick, James Wymer, Stephen A Goutman, Daragh Heitzman, Terry Heiman-Patterson, Carlayne E Jackson, Colin Quinn, Jeffrey D Rothstein, Edward J Kasarskis, Jonathan Katz, Liberty Jenkins, Shafeeq Ladha, Timothy M Miller, Stephen N Scelsa, Tuan H Vu, Christina N Fournier, Jonathan D Glass, Kristin M Johnson, Andrea Swenson, Namita A Goyal, Gary L Pattee, Patricia L Andres, Suma Babu, Marianne Chase, Derek Dagostino, Samuel P Dickson, Noel Ellison, Meghan Hall, Kent Hendrix, Gale Kittle, Michelle McGovern, Joseph Ostrow, Lindsay Pothier, Rebecca Randall, Jeremy M Shefner, Alexander V Sherman, Eric Tustison, Prasha Vigneswaran, Jason Walker, Hong Yu, James Chan, Janet Wittes, Joshua Cohen, Justin Klee, Kent Leslie, Rudolph E Tanzi, Walter Gilbert, Patrick D Yeramian, David Schoenfeld, Merit E Cudkowicz. Trial of Sodium Phenylbutyrate-Taurursodiol for Amyotrophic Lateral Sclerosis.
The New England journal of medicine.
2020 09; 383(10):919-930. doi:
10.1056/nejmoa1916945. [PMID: 32877582] - Ross Mangum, Claudia Soler-Alfonso, Sherri Birchansky, Alexandra Stevens. Survival and Neurologic Recovery After Prompt Diagnosis and Aggressive Management of Severe Idiopathic Hyperammonemic Encephalopathy in a Patient with Acute Myeloid Leukemia.
Journal of pediatric hematology/oncology.
2020 08; 42(6):e452-e455. doi:
10.1097/mph.0000000000001579. [PMID: 31415019] - Chongshan Dai, Qiangqiang Liu, Daowen Li, Gaurav Sharma, Jianli Xiong, Xilong Xiao. Molecular Insights of Copper Sulfate Exposure-Induced Nephrotoxicity: Involvement of Oxidative and Endoplasmic Reticulum Stress Pathways.
Biomolecules.
2020 07; 10(7):. doi:
10.3390/biom10071010. [PMID: 32650488] - Jingshu Liu, Rachel L Taylor, Richard A Baines, Lisa Swanton, Sally Freeman, Barbara Corneo, Achchhe Patel, Alan Marmorstein, Travis Knudsen, Graeme C Black, Forbes Manson. Small Molecules Restore Bestrophin 1 Expression and Function of Both Dominant and Recessive Bestrophinopathies in Patient-Derived Retinal Pigment Epithelium.
Investigative ophthalmology & visual science.
2020 05; 61(5):28. doi:
10.1167/iovs.61.5.28. [PMID: 32421148] - Martin D Salazar, Nathan B Zelt, Robert Saldivar, Charles P Kuntz, Sheng Chen, Wesley D Penn, Richard Bonneau, Julia Koehler Leman, Jonathan P Schlebach. Classification of the Molecular Defects Associated with Pathogenic Variants of the SLC6A8 Creatine Transporter.
Biochemistry.
2020 04; 59(13):1367-1377. doi:
10.1021/acs.biochem.9b00956. [PMID: 32207963] - Ke Chen, Hu Hua, Ziyang Zhu, Tong Wu, Zhanjun Jia, Qianqi Liu. Artemisinin and dihydroartemisinin promote β-cell apoptosis induced by palmitate via enhancing ER stress.
Apoptosis : an international journal on programmed cell death.
2020 04; 25(3-4):192-204. doi:
10.1007/s10495-019-01587-z. [PMID: 31894447] - Mayumi Matsufuji, Eiko Takeshita, Masayuki Nakashima, Yoriko Watanabe, Kaori Fukui, Toshio Hanai, Hiromi Ishibashi, Sachio Takashima. Sodium phenylbutyrate improved the clinical state in an adult patient with arginase 1 deficiency.
Brain & development.
2020 Feb; 42(2):231-235. doi:
10.1016/j.braindev.2019.09.002. [PMID: 31604595] - Yifan Wu, Yiyang Zhao, Xuanhong He, Zhiqiang He, Tian Wang, Linxi Wan, Lai Chen, Nianlong Yan. Hydroxypropyl‑β‑cyclodextrin attenuates the epithelial‑to‑mesenchymal transition via endoplasmic reticulum stress in MDA‑MB‑231 breast cancer cells.
Molecular medicine reports.
2020 01; 21(1):249-257. doi:
10.3892/mmr.2019.10802. [PMID: 31746388] - Ali El-Kasaby, Ameya Kasture, Florian Koban, Matej Hotka, Hafiz M M Asjad, Helmut Kubista, Michael Freissmuth, Sonja Sucic. Rescue by 4-phenylbutyrate of several misfolded creatine transporter-1 variants linked to the creatine transporter deficiency syndrome.
Neuropharmacology.
2019 12; 161(?):107572. doi:
10.1016/j.neuropharm.2019.03.015. [PMID: 30885608] - Fernando Andrade, Isidro Vitoria, Elena Martín Hernández, Guillem Pintos-Morell, Patricia Correcher, Rocío Puig-Piña, Pilar Quijada-Fraile, Luis Peña-Quintana, Ana Mª Marquez, Olatz Villate, Mª Teresa García Silva, Javier de Las Heras, Leticia Ceberio, Esmeralda Rodrigues, Teresa Almeida Campos, Raquel Yahyaoui, Javier Blasco, Inmaculada Vives-Piñera, David Gil, Mireia Del Toro, Mónica Ruiz-Pons, Elvira Cañedo, Miguel Angel Barba Romero, Mª Concepción García-Jiménez, Luis Aldámiz-Echevarría. Quantification of urinary derivatives of Phenylbutyric and Benzoic acids by LC-MS/MS as treatment compliance biomarkers in Urea Cycle disorders.
Journal of pharmaceutical and biomedical analysis.
2019 Nov; 176(?):112798. doi:
10.1016/j.jpba.2019.112798. [PMID: 31394303] - Satoshi Nakano, Shuhei Osaka, Yusuke Sabu, Kei Minowa, Saeko Hirai, Hiroki Kondou, Takeshi Kimura, Yoshihiro Azuma, Satoshi Watanabe, Ayano Inui, Kazuhiko Bessho, Hidefumi Nakamura, Hironori Kusano, Atsuko Nakazawa, Ken Tanikawa, Masayoshi Kage, Toshiaki Shimizu, Hiroyuki Kusuhara, Yoh Zen, Mitsuyoshi Suzuki, Hisamitsu Hayashi. Effect of food on the pharmacokinetics and therapeutic efficacy of 4-phenylbutyrate in progressive familial intrahepatic cholestasis.
Scientific reports.
2019 11; 9(1):17075. doi:
10.1038/s41598-019-53628-x. [PMID: 31745229] - Junlin Pan, YuanYuan Yao, Xiuxiu Guo, Fengyun Kong, Jun Zhou, Xiaoqian Meng. Endoplasmic reticulum stress, a novel significant mechanism responsible for DEHP-induced increased distance between seminiferous tubule of mouse testis.
Journal of cellular physiology.
2019 11; 234(11):19807-19823. doi:
10.1002/jcp.28580. [PMID: 30989653] - Hailong Hu, Xingpei Fan, Yao Yin, Qian Guo, Daqian Yang, Xiangjuan Wei, Boya Zhang, Jing Liu, Qiong Wu, Yuri Oh, Kun Chen, Yujie Feng, Liping Hou, Li Li, Ning Gu. Mechanisms of titanium dioxide nanoparticle-induced oxidative stress and modulation of plasma glucose in mice.
Environmental toxicology.
2019 Nov; 34(11):1221-1235. doi:
10.1002/tox.22823. [PMID: 31298478] - Shaolei Ma, Xiangrong Zuo, Yujie Wang, Jing Yao, Yongzhi Zhou, Changsheng Xu. [Protective effect of sodium 4-phenylbutyrate on rats with acute respiratory distress syndrome related right ventricular dysfunction by alleviating endoplasmic reticulum stress].
Zhonghua wei zhong bing ji jiu yi xue.
2019 Oct; 31(10):1269-1274. doi:
10.3760/cma.j.issn.2095-4352.2019.10.017. [PMID: 31771727] - Ester Zito. Targeting ER stress/ER stress response in myopathies.
Redox biology.
2019 09; 26(?):101232. doi:
10.1016/j.redox.2019.101232. [PMID: 31181458] - Logan K Townsend, Kyle D Medak, Willem T Peppler, Grace M Meers, R Scott Rector, Paul J LeBlanc, David C Wright. High-saturated-fat diet-induced obesity causes hepatic interleukin-6 resistance via endoplasmic reticulum stress.
Journal of lipid research.
2019 07; 60(7):1236-1249. doi:
10.1194/jlr.m092510. [PMID: 31085628] - Edward G Lynn, Šárka Lhoták, Paul Lebeau, Jae Hyun Byun, Jack Chen, Khrystyna Platko, Chunhua Shi, Edward R O'Brien, Richard C Austin. 4-Phenylbutyrate protects against atherosclerotic lesion growth by increasing the expression of HSP25 in macrophages and in the circulation of Apoe-/- mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2019 07; 33(7):8406-8422. doi:
10.1096/fj.201802293rr. [PMID: 30964709] - Kuo-How Huang, Siao-Syun Guan, Wei-Han Lin, Cheng-Tien Wu, Meei-Ling Sheu, Chih-Kang Chiang, Shing-Hwa Liu. Role of Calbindin-D28k in Diabetes-Associated Advanced Glycation End-Products-Induced Renal Proximal Tubule Cell Injury.
Cells.
2019 06; 8(7):. doi:
10.3390/cells8070660. [PMID: 31262060] - Qi Zhou, Wenjia Guo, Yanan Jia, Jiancheng Xu. Effect of 4-Phenylbutyric Acid and Tauroursodeoxycholic Acid on Magnesium and Calcium Metabolism in Streptozocin-Induced Type 1 Diabetic Mice.
Biological trace element research.
2019 Jun; 189(2):501-510. doi:
10.1007/s12011-018-1494-8. [PMID: 30171596] - Bo He, Régis Moreau. Lipid-regulating properties of butyric acid and 4-phenylbutyric acid: Molecular mechanisms and therapeutic applications.
Pharmacological research.
2019 06; 144(?):116-131. doi:
10.1016/j.phrs.2019.04.002. [PMID: 30954630] - Yun-Dong You, Wen-Hong Deng, Wen-Yi Guo, Liang Zhao, Fang-Chao Mei, Yu-Pu Hong, Yu Zhou, Jia Yu, Sheng Xu, Wei-Xing Wang. 4-Phenylbutyric Acid Attenuates Endoplasmic Reticulum Stress-Mediated Intestinal Epithelial Cell Apoptosis in Rats with Severe Acute Pancreatitis.
Digestive diseases and sciences.
2019 06; 64(6):1535-1547. doi:
10.1007/s10620-018-5437-1. [PMID: 30607691] - Safaa Naiel, Rachel E Carlisle, Chao Lu, Victor Tat, Jeffrey G Dickhout. Endoplasmic reticulum stress inhibition blunts the development of essential hypertension in the spontaneously hypertensive rat.
American journal of physiology. Heart and circulatory physiology.
2019 05; 316(5):H1214-H1223. doi:
10.1152/ajpheart.00523.2018. [PMID: 30848678] - Richa Randhawa, Rishi Bhardwaj, Tanzeer Kaur. Amelioration of hyperoxaluria-induced kidney dysfunction by chemical chaperone 4-phenylbutyric acid.
Urolithiasis.
2019 Apr; 47(2):171-179. doi:
10.1007/s00240-018-1064-8. [PMID: 29947992] - Min-Ge Wang, Rui-Feng Fan, Wen-Hui Li, Dong Zhang, Du-Bao Yang, Zhen-Yong Wang, Lin Wang. Activation of PERK-eIF2α-ATF4-CHOP axis triggered by excessive ER stress contributes to lead-induced nephrotoxicity.
Biochimica et biophysica acta. Molecular cell research.
2019 04; 1866(4):713-726. doi:
10.1016/j.bbamcr.2018.12.002. [PMID: 30528975] - Xiaohan Zhang, Shanshan Shao, Lifang Zhao, Rui Yang, Meng Zhao, Li Fang, Mengzhu Li, Wenbin Chen, Yongfeng Song, Chao Xu, Xiaoming Zhou, Jiajun Zhao, Ling Gao. ER stress contributes to high-fat diet-induced decrease of thyroglobulin and hypothyroidism.
American journal of physiology. Endocrinology and metabolism.
2019 03; 316(3):E510-E518. doi:
10.1152/ajpendo.00194.2018. [PMID: 30620634] - Mathilde L Bonnemaison, Eileen S Marks-Nelson, Erika I Boesen. Sodium 4-phenylbutyrate treatment protects against renal injury in NZBWF1 mice.
Clinical science (London, England : 1979).
2019 01; 133(2):167-180. doi:
10.1042/cs20180562. [PMID: 30617186] - S Giva, J Finnegan, P Ihidero, G Maguire, B Power, I Knerr, A Monavari. Hyperammonaemia in Neonates and Young Children: Potential Metabolic Causes, Diagnostic Approaches and Clinical Consequences.
Irish medical journal.
2019 01; 112(1):858. doi:
NULL. [PMID: 30719899] - Senait Ashenafi, Wondwossen Amogne, Endale Kassa, Nebiat Gebreselassie, Amsalu Bekele, Getachew Aseffa, Meron Getachew, Abraham Aseffa, Alemayehu Worku, Ulf Hammar, Peter Bergman, Getachew Aderaye, Jan Andersson, Susanna Brighenti. Daily Nutritional Supplementation with Vitamin D₃ and Phenylbutyrate to Treatment-Naïve HIV Patients Tested in a Randomized Placebo-Controlled Trial.
Nutrients.
2019 Jan; 11(1):. doi:
10.3390/nu11010133. [PMID: 30634590] - Sheng Wang, Jiajie Luan, Xiongwen Lv. Inhibition of Endoplasmic Reticulum Stress Attenuated Ethanol-Induced Exosomal miR-122 and Acute Liver Injury in Mice.
Alcohol and alcoholism (Oxford, Oxfordshire).
2019 Jan; 54(5):465-471. doi:
10.1093/alcalc/agz058. [PMID: 31361816] - Chang Ho Kang, Joung Hun Park, Eun Seon Lee, Seol Ki Paeng, Ho Byoung Chae, Yong Hun Chi, Sang Yeol Lee. Exploring Novel Functions of the Small GTPase Ypt1p under Heat-Shock by Characterizing a Temperature-Sensitive Mutant Yeast Strain, ypt1-G80D.
International journal of molecular sciences.
2019 Jan; 20(1):. doi:
10.3390/ijms20010132. [PMID: 30609659] - Minu Sharma, Amarjit S Naura, S K Singla. Modulatory effect of 4-phenyl butyric acid on hyperoxaluria-induced renal injury and inflammation.
Molecular and cellular biochemistry.
2019 Jan; 451(1-2):185-196. doi:
10.1007/s11010-018-3405-x. [PMID: 30066041] - Er Hui Wang, San Qiao Yao, Ling Tao, Jin Yan Xi. Sodium 4-phenylbutyrate Attenuates High-fat Diet-induced Impaired Spermatogenesis.
Biomedical and environmental sciences : BES.
2018 Dec; 31(12):876-882. doi:
10.3967/bes2018.118. [PMID: 30636657] - Yu-Pu Hong, Wen-Hong Deng, Wen-Yi Guo, Qiao Shi, Liang Zhao, Yun-Dong You, Fang-Chao Mei, Yu Zhou, Chen-Yang Wang, Chen Chen, Jia Yu, Wei-Xing Wang. Inhibition of endoplasmic reticulum stress by 4-phenylbutyric acid prevents vital organ injury in rat acute pancreatitis.
American journal of physiology. Gastrointestinal and liver physiology.
2018 11; 315(5):G838-G847. doi:
10.1152/ajpgi.00102.2018. [PMID: 30138574] - Anne-Sophie Wilding, Christine Patte-Mensah, Omar Taleb, Susana Brun, Véronique Kemmel, Ayikoe-Guy Mensah-Nyagan. Protective effect of 4-Phenylbutyrate against proteolipid protein mutation-induced endoplasmic reticulum stress and oligodendroglial cell death.
Neurochemistry international.
2018 09; 118(?):185-194. doi:
10.1016/j.neuint.2018.06.008. [PMID: 29936187] - Junjie Guo, Jianbing Zhu, Leilei Ma, Hongtao Shi, Jiachang Hu, Shuning Zhang, Lei Hou, Fengqiang Xu, Yi An, Haichu Yu, Junbo Ge. Chronic Kidney Disease Exacerbates Myocardial Ischemia Reperfusion Injury: Role of Endoplasmic Reticulum Stress-Mediated Apoptosis.
Shock (Augusta, Ga.).
2018 06; 49(6):712-720. doi:
10.1097/shk.0000000000000970. [PMID: 28846567] - Mai Hazekawa, Kazuhiko Ono, Takuya Nishinakagawa, Tomoyo Kawakubo-Yasukochi, Manabu Nakashima. In Vitro Anti-inflammatory Effects of the Phenylbutyric Acid Metabolite Phenylacetyl Glutamine.
Biological & pharmaceutical bulletin.
2018 Jun; 41(6):961-966. doi:
10.1248/bpb.b17-00799. [PMID: 29526885] - Qian Deng, Liang Liang, Quanhai Liu, Wanli Duan, Yazhuo Jiang, Liandong Zhang. Autophagy is a major mechanism for the dual effects of curcumin on renal cell carcinoma cells.
European journal of pharmacology.
2018 May; 826(?):24-30. doi:
10.1016/j.ejphar.2018.02.038. [PMID: 29501864] - Yu Gu, Fei Huang, Yanling Wang, Chaojin Chen, Shan Wu, Shaoli Zhou, Ziqing Hei, Dongdong Yuan. Connexin32 plays a crucial role in ROS-mediated endoplasmic reticulum stress apoptosis signaling pathway in ischemia reperfusion-induced acute kidney injury.
Journal of translational medicine.
2018 05; 16(1):117. doi:
10.1186/s12967-018-1493-8. [PMID: 29728112] - Hailong Hu, Li Li, Qian Guo, He Zong, Yuheng Yan, Yao Yin, Yu Wang, Yuri Oh, Yujie Feng, Qiong Wu, Ning Gu. RNA sequencing analysis shows that titanium dioxide nanoparticles induce endoplasmic reticulum stress, which has a central role in mediating plasma glucose in mice.
Nanotoxicology.
2018 05; 12(4):341-356. doi:
10.1080/17435390.2018.1446560. [PMID: 29510645] - Ru Ying, Sheng-Wei Li, Jia-Yuan Chen, Hai-Feng Zhang, Ying Yang, Zhen-Jie Gu, Yang-Xin Chen, Jing-Feng Wang. Endoplasmic reticulum stress in perivascular adipose tissue promotes destabilization of atherosclerotic plaque by regulating GM-CSF paracrine.
Journal of translational medicine.
2018 04; 16(1):105. doi:
10.1186/s12967-018-1481-z. [PMID: 29669585] - Juan Zhang, Wen-Shu Zhao, Xin Wang, Lin Xu, Xin-Chun Yang. Palmitic Acid Increases Endothelin-1 Expression in Vascular Endothelial Cells through the Induction of Endoplasmic Reticulum Stress and Protein Kinase C Signaling.
Cardiology.
2018; 140(3):133-140. doi:
10.1159/000490093. [PMID: 29996135] - Lu Zou, Xiaoyan Li, Nan Wu, Pengyu Jia, Chunting Liu, Dalin Jia. Palmitate induces myocardial lipotoxic injury via the endoplasmic reticulum stress‑mediated apoptosis pathway.
Molecular medicine reports.
2017 Nov; 16(5):6934-6939. doi:
10.3892/mmr.2017.7404. [PMID: 28901411] - Aric Huang, Tayler L Young, Vi T Dang, Yuanyuan Shi, Cameron S McAlpine, Geoff H Werstuck. 4-phenylbutyrate and valproate treatment attenuates the progression of atherosclerosis and stabilizes existing plaques.
Atherosclerosis.
2017 Nov; 266(?):103-112. doi:
10.1016/j.atherosclerosis.2017.09.034. [PMID: 29024862] - Ashraf U Nissar, Love Sharma, Malik A Mudasir, Lone A Nazir, Sheikh A Umar, Parduman R Sharma, Ram A Vishwakarma, Sheikh A Tasduq. Chemical chaperone 4-phenyl butyric acid (4-PBA) reduces hepatocellular lipid accumulation and lipotoxicity through induction of autophagy.
Journal of lipid research.
2017 09; 58(9):1855-1868. doi:
10.1194/jlr.m077537. [PMID: 28655725] - Keishi Yamasaki, Taisuke Enokida, Kazuaki Taguchi, Shigeyuki Miyamura, Akito Kawai, Shuichi Miyamoto, Toru Maruyama, Hakaru Seo, Masaki Otagiri. Species Differences in the Binding of Sodium 4-Phenylbutyrate to Serum Albumin.
Journal of pharmaceutical sciences.
2017 09; 106(9):2860-2867. doi:
10.1016/j.xphs.2017.04.025. [PMID: 28456727] - Dilip Shah, Freddy Romero, Zhi Guo, Jianxin Sun, Jonathan Li, Caleb B Kallen, Ulhas P Naik, Ross Summer. Obesity-Induced Endoplasmic Reticulum Stress Causes Lung Endothelial Dysfunction and Promotes Acute Lung Injury.
American journal of respiratory cell and molecular biology.
2017 08; 57(2):204-215. doi:
10.1165/rcmb.2016-0310oc. [PMID: 28277743] - Mingxue Di, Lin Wang, Mengmeng Li, Yu Zhang, Xinxin Liu, Renya Zeng, Han Wang, Yifei Chen, Weijia Chen, Yun Zhang, Mei Zhang. Dickkopf1 destabilizes atherosclerotic plaques and promotes plaque formation by inducing apoptosis of endothelial cells through activation of ER stress.
Cell death & disease.
2017 07; 8(7):e2917. doi:
10.1038/cddis.2017.277. [PMID: 28703797] - Long The Nguyen, Sonia Saad, Yi Tan, Carol Pollock, Hui Chen. Maternal high-fat diet induces metabolic stress response disorders in offspring hypothalamus.
Journal of molecular endocrinology.
2017 07; 59(1):81-92. doi:
10.1530/jme-17-0056. [PMID: 28500249] - Neža Palir, Jos P N Ruiter, Ronald J A Wanders, Riekelt H Houtkooper. Identification of enzymes involved in oxidation of phenylbutyrate.
Journal of lipid research.
2017 05; 58(5):955-961. doi:
10.1194/jlr.m075317. [PMID: 28283530] - Chandak Upagupta, Rachel E Carlisle, Jeffrey G Dickhout. Analysis of the potency of various low molecular weight chemical chaperones to prevent protein aggregation.
Biochemical and biophysical research communications.
2017 04; 486(1):163-170. doi:
10.1016/j.bbrc.2017.03.019. [PMID: 28285140] - Yanbiao Ai, Zhenzhen Sun, Chuan Peng, Lingli Liu, Xiaoqiu Xiao, Jibin Li. Homocysteine Induces Hepatic Steatosis Involving ER Stress Response in High Methionine Diet-Fed Mice.
Nutrients.
2017 Apr; 9(4):. doi:
10.3390/nu9040346. [PMID: 28368295] - Doreen Braun, Ulrich Schweizer. The Chemical Chaperone Phenylbutyrate Rescues MCT8 Mutations Associated With Milder Phenotypes in Patients With Allan-Herndon-Dudley Syndrome.
Endocrinology.
2017 03; 158(3):678-691. doi:
10.1210/en.2016-1530. [PMID: 27977298] - Viola Pomozi, Christopher Brampton, Flóra Szeri, Dóra Dedinszki, Eszter Kozák, Koen van de Wetering, Hi'ilani Hopkins, Ludovic Martin, András Váradi, Olivier Le Saux. Functional Rescue of ABCC6 Deficiency by 4-Phenylbutyrate Therapy Reduces Dystrophic Calcification in Abcc6-/- Mice.
The Journal of investigative dermatology.
2017 03; 137(3):595-602. doi:
10.1016/j.jid.2016.10.035. [PMID: 27826008] - Shin Mukai, Yoko Ogawa, Fumihiko Urano, Chie Kudo-Saito, Yutaka Kawakami, Kazuo Tsubota. Novel Treatment of Chronic Graft-Versus-Host Disease in Mice Using the ER Stress Reducer 4-Phenylbutyric Acid.
Scientific reports.
2017 02; 7(?):41939. doi:
10.1038/srep41939. [PMID: 28165054] - Zahraa Mohammed-Ali, Chao Lu, Mandeep K Marway, Rachel E Carlisle, Kjetil Ask, Dusan Lukic, Joan C Krepinsky, Jeffrey G Dickhout. Endoplasmic reticulum stress inhibition attenuates hypertensive chronic kidney disease through reduction in proteinuria.
Scientific reports.
2017 02; 7(?):41572. doi:
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American journal of physiology. Endocrinology and metabolism.
2017 01; 312(1):E48-E57. doi:
10.1152/ajpendo.00275.2016. [PMID: 27879249] - Victoria Yum, Rachel E Carlisle, Chao Lu, Elise Brimble, Jasmine Chahal, Chandak Upagupta, Kjetil Ask, Jeffrey G Dickhout. Endoplasmic reticulum stress inhibition limits the progression of chronic kidney disease in the Dahl salt-sensitive rat.
American journal of physiology. Renal physiology.
2017 01; 312(1):F230-F244. doi:
10.1152/ajprenal.00119.2016. [PMID: 28069662] - Jin-Guo Li, Qi Hao, Ying-Xue Liu, Peng Li, Peng Li, Xia-Yan Shao, Hua Tian, Yong-Qi Fang, Shu-Tong Yao. [Advanced glycated albumin induces macrophage apoptosis via activating caspase-12 pathway].
Sheng li xue bao : [Acta physiologica Sinica].
2016 Dec; 68(6):733-739. doi:
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Disease models & mechanisms.
2016 11; 9(11):1317-1328. doi:
10.1242/dmm.024216. [PMID: 27519691] - Hong-Wa Yung, Patji Alnæs-Katjavivi, Carolyn J P Jones, Tatiana El-Bacha, Michaela Golic, Anne-Cathrine Staff, Graham J Burton. Placental endoplasmic reticulum stress in gestational diabetes: the potential for therapeutic intervention with chemical chaperones and antioxidants.
Diabetologia.
2016 10; 59(10):2240-50. doi:
10.1007/s00125-016-4040-2. [PMID: 27406815] - H Gao, X Y Zhang, L Y Yue, Z Y Liu, N N Jia, D X Chen, Z P Duan, F Ren. [Role of endoplasmic reticulum stress-mediated glycogen synthase kinase 3β activity in pathogenesis of acute liver failure in mice].
Zhonghua yi xue za zhi.
2016 Sep; 96(34):2734-2738. doi:
10.3760/cma.j.issn.0376-2491.2016.34.010. [PMID: 27667108] - Lingyan Zhou, Shuyan Ding, Yujie Li, Laicheng Wang, Wenbin Chen, Tao Bo, Kunpeng Wu, Congcong Li, Xiaojing Liu, Jiajun Zhao, Chao Xu, Ling Gao. Endoplasmic Reticulum Stress May Play a Pivotal Role in Lipid Metabolic Disorders in a Novel Mouse Model of Subclinical Hypothyroidism.
Scientific reports.
2016 08; 6(?):31381. doi:
10.1038/srep31381. [PMID: 27539723] - Lu-Ping Ren, Xian Yu, Guang-Yao Song, Pu Zhang, Li-Na Sun, Shu-Chun Chen, Zhi-Juan Hu, Xue-Mei Zhang. Impact of activating transcription factor 4 signaling on lipogenesis in HepG2 cells.
Molecular medicine reports.
2016 Aug; 14(2):1649-58. doi:
10.3892/mmr.2016.5453. [PMID: 27357269] - Guohua Song, Xia Wu, Pu Zhang, Yang Yu, Mingfeng Yang, Peng Jiao, Ni Wang, Haiming Song, You Wu, Xiangjian Zhang, Huaxia Liu, Shucun Qin. High-density lipoprotein inhibits ox-LDL-induced adipokine secretion by upregulating SR-BI expression and suppressing ER Stress pathway.
Scientific reports.
2016 07; 6(?):30889. doi:
10.1038/srep30889. [PMID: 27468698] - Taisuke Enokida, Keishi Yamasaki, Yuko Okamoto, Kazuaki Taguchi, Takako Ishiguro, Toru Maruyama, Hakaru Seo, Masaki Otagiri. Tyrosine411 and Arginine410 of Human Serum Albumin Play an Important Role in the Binding of Sodium 4-Phenylbutyrate to Site II.
Journal of pharmaceutical sciences.
2016 06; 105(6):1987-1994. doi:
10.1016/j.xphs.2016.03.012. [PMID: 27113474] - Wendy L van der Woerd, Catharina G K Wichers, Anna L Vestergaard, Jens Peter Andersen, Coen C Paulusma, Roderick H J Houwen, Stan F J van de Graaf. Rescue of defective ATP8B1 trafficking by CFTR correctors as a therapeutic strategy for familial intrahepatic cholestasis.
Journal of hepatology.
2016 06; 64(6):1339-47. doi:
10.1016/j.jhep.2016.02.001. [PMID: 26879107] - Ai-Li Cao, Li Wang, Xia Chen, Yun-Man Wang, Heng-Jiang Guo, Shuang Chu, Cheng Liu, Xue-Mei Zhang, Wen Peng. Ursodeoxycholic acid and 4-phenylbutyrate prevent endoplasmic reticulum stress-induced podocyte apoptosis in diabetic nephropathy.
Laboratory investigation; a journal of technical methods and pathology.
2016 06; 96(6):610-22. doi:
10.1038/labinvest.2016.44. [PMID: 26999661] - Shing-Hwa Liu, Ching-Chin Yang, Ding-Cheng Chan, Cheng-Tien Wu, Li-Ping Chen, Jenq-Wen Huang, Kuan-Yu Hung, Chih-Kang Chiang. Chemical chaperon 4-phenylbutyrate protects against the endoplasmic reticulum stress-mediated renal fibrosis in vivo and in vitro.
Oncotarget.
2016 Apr; 7(16):22116-27. doi:
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European journal of pharmacology.
2016 Apr; 777(?):104-12. doi:
10.1016/j.ejphar.2016.02.068. [PMID: 26948310] - Qi Zhou, Di Wang, Jiancheng Xu, Baorong Chi. Effect of Tauroursodeoxycholic Acid and 4-Phenylbutyric Acid on Metabolism of Copper and Zinc in Type 1 Diabetic Mice Model.
Biological trace element research.
2016 Apr; 170(2):348-56. doi:
10.1007/s12011-015-0474-5. [PMID: 26282527] - Benjamin L Shneider, Amy Morris, Jerry Vockley. Possible Phenylacetate Hepatotoxicity During 4-Phenylbutyrate Therapy of Byler Disease.
Journal of pediatric gastroenterology and nutrition.
2016 Mar; 62(3):424-8. doi:
10.1097/mpg.0000000000001082. [PMID: 26756876] - Joseph L Roberts, Bo He, Anjeza Erickson, Régis Moreau. Improvement of mTORC1-driven overproduction of apoB-containing triacylglyceride-rich lipoproteins by short-chain fatty acids, 4-phenylbutyric acid and (R)-α-lipoic acid, in human hepatocellular carcinoma cells.
Biochimica et biophysica acta.
2016 Mar; 1861(3):166-76. doi:
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Molecular medicine reports.
2016 Feb; 13(2):1227-33. doi:
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Nutrients.
2016 Jan; 8(1):. doi:
10.3390/nu8010055. [PMID: 26805874] - Xiaochen Yang, Renu Srivastava, Stephen H Howell, Diane C Bassham. Activation of autophagy by unfolded proteins during endoplasmic reticulum stress.
The Plant journal : for cell and molecular biology.
2016 Jan; 85(1):83-95. doi:
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PloS one.
2016; 11(2):e0150098. doi:
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Endocrinology.
2015 Dec; 156(12):4720-30. doi:
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International journal of molecular medicine.
2015 Dec; 36(6):1519-28. doi:
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