Pyrimethamine (BioDeep_00000002347)

human metabolite blood metabolite Chemicals and Drugs

代谢物信息卡片

5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine

化学式: C12H13ClN4 (248.0828688)
中文名称: 乙胺嘧啶
谱图信息: 最多检出来源 Homo sapiens(blood) 13.54%

分子结构信息

SMILES: CCC1=C(C(=NC(=N1)N)N)C2=CC=C(C=C2)Cl
InChI: InChI=1S/C12H13ClN4/c1-2-9-10(11(14)17-12(15)16-9)7-3-5-8(13)6-4-7/h3-6H,2H2,1H3,(H4,14,15,16,17)

描述信息

Pyrimethamine is only found in individuals that have used or taken this drug. It is one of the folic acid antagonists that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis. [PubChem]Pyrimethamine inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purines and pyrimidines, which are essential for DNA synthesis and cell multiplication. This leads to failure of nuclear division at the time of schizont formation in erythrocytes and liver.
CONFIDENCE standard compound; INTERNAL_ID 1363; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7091; ORIGINAL_PRECURSOR_SCAN_NO 7088
CONFIDENCE standard compound; INTERNAL_ID 1363; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7117; ORIGINAL_PRECURSOR_SCAN_NO 7114
CONFIDENCE standard compound; INTERNAL_ID 1363; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7128; ORIGINAL_PRECURSOR_SCAN_NO 7126
CONFIDENCE standard compound; INTERNAL_ID 1363; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7117; ORIGINAL_PRECURSOR_SCAN_NO 7115
CONFIDENCE standard compound; INTERNAL_ID 1363; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7093; ORIGINAL_PRECURSOR_SCAN_NO 7091
P - Antiparasitic products, insecticides and repellents > P01 - Antiprotozoals > P01B - Antimalarials > P01BD - Diaminopyrimidines
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent
C471 - Enzyme Inhibitor > C2153 - Dihydrofolate Reductase Inhibitor
D004791 - Enzyme Inhibitors > D005493 - Folic Acid Antagonists

同义名列表

28 个代谢物同义名

5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine; 5-(4-Chlorophenyl)-6-ethyl-2,4-diaminopyrimidine; 2,4-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine; 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine; 2,4-Diamino-5-(p-chlorophenyl)-6-ethylpyrimidine; 5-(4-Chlorophenyl)-2,4-diamino-6-ethylpyrimidine; 2,4-Diamino-5-chlorophenyl-6-ethylpyrimidine; GlaxoSmithKline brand OF pyrimethamine; Glaxo wellcome brand OF pyrimethamine; Wellcome brand OF pyrimethamine; Aventis brand OF pyrimethamine; Diaminopyritamin; Ethylpyrimidine; Pyrimethaminum; Pyremethamine; pyrimethamine; Pirimetamina; Pyrimethamin; Primethamine; Pirimetamin; Chloridine; Chloridin; Tindurine; Chloridyn; Daraprim; Malocide; Cd; Pyrimethamine

数据库引用编号

24 个数据库交叉引用编号

ChEBI: CHEBI:8673
KEGG: C07391
KEGGdrug: D00488
PubChem: 4993
HMDB: HMDB0014350
Metlin: METLIN2204
DrugBank: DB00205
ChEMBL: CHEMBL36
Wikipedia: Pyrimethamine
MeSH: Pyrimethamine
chemspider: 4819
CAS: 58-14-0
MoNA: LU136302
MoNA: LU136306
MoNA: LU136303
MoNA: LU136304
MoNA: LU136305
MoNA: LU136301
PMhub: MS000002402
PubChem: 9595
PDB-CCD: CP6
NIKKAJI: J4.589F
RefMet: Pyrimethamine
KNApSAcK: 8673

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 - Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Samuel Cota Teixeira, Marina Paschoalino, Guilherme de Souza, Alessandra Monteiro Rosini, Joed Pires de Lima Junior, Luana Carvalho Luz, Aryani Felixa Fajardo Martínez, Rosiane Nascimento Alves, Marcos Paulo Oliveira Almeida, Jaqueline Lopes Damasceno, Marcelo José Barbosa Silva, Francesca Ietta, Bellisa Freitas Barbosa, Eloisa Amália Vieira Ferro, Carlos Henrique Gomes Martins. Rottlerin impairs early and late steps of Toxoplasma gondii infection in human trophoblast cells and villous explants. Chemico-biological interactions. 2023 Sep; ?(?):110716. doi: 10.1016/j.cbi.2023.110716. [PMID: 37722575]
Akram Hematizadeh, Mohammad Ali Ebrahimzadeh, Shahabeddin Sarvi, Mitra Sadeghi, Ahmad Daryani, Shirzad Gholami, Tooran Nayeri, Seyed Abdollah Hosseini. In Vitro and In Vivo Anti-parasitic Activity of Sambucus ebulus and Feijoa sellowiana Extracts Silver Nanoparticles on Toxoplasma gondii Tachyzoites. Acta parasitologica. 2023 Jun; ?(?):. doi: 10.1007/s11686-023-00689-8. [PMID: 37330943]
Chen Zhang, Kah Yean Lum, Aya C Taki, Robin B Gasser, Joseph J Byrne, Luis J Montaner, Ian Tietjen, Vicky M Avery, Rohan A Davis. Using a Bioactive Eremophila-Derived Serrulatane Scaffold to Generate a Unique Carbamate Library for Anti-infective Evaluations. Journal of natural products. 2023 03; 86(3):557-565. doi: 10.1021/acs.jnatprod.2c01041. [PMID: 36799121]
Jesse C Nussbaum, Azher Hussain, Bennett Ma, K Chris Min, Raymond Evers, Yun Li, Graigory Garrett, S Aubrey Stoch, Marian Iwamoto. Assessment of the Effect of Pyrimethamine, a Potent Inhibitor of Multidrug and Toxin Extrusion Protein 1/2K, on the Pharmacokinetics of Gefapixant (MK-7264), a P2X3 Receptor Antagonist. Clinical pharmacology in drug development. 2022 01; 11(1):123-128. doi: 10.1002/cpdd.988. [PMID: 34145987]
Barrios Leda Castaño, Andrea Alice Silva, Lina L Hernandez-Velasco, Ana Paula Da Silva Pinheiro, Daniel Gibaldi, José Roberto Mineo, Neide Maria Silva, Joseli Lannes-Vieira. Sulfadiazine Plus Pyrimethamine Therapy Reversed Multiple Behavioral and Neurocognitive Changes in Long-Term Chronic Toxoplasmosis by Reducing Brain Cyst Load and Inflammation-Related Alterations. Frontiers in immunology. 2022; 13(?):822567. doi: 10.3389/fimmu.2022.822567. [PMID: 35572567]
Hina Shamshad, Ali Sayqal, Jahan Zeb, Agha Zeeshan Mirza. Simultaneous Determination of Chloroquine and Pyrimethamine with Cetirizine in an Active Form and Human Serum by RP-HPLC. Journal of chromatographic science. 2021 Oct; 59(10):923-927. doi: 10.1093/chromsci/bmab018. [PMID: 33621328]
Aline Reetz Conceição, Deisi Nara Belucik, Lilian Missio, Luiz Gustavo Brenner, Matheus Henrique Monteiro, Kleber Silva Ribeiro, Deise Fialho Costa, Maria Clara da Silva Valadão, Alessandra Gonçalves Commodaro, João Rafael de Oliveira Dias, Rubens Belfort. Ocular Findings in Infants with Congenital Toxoplasmosis after a Toxoplasmosis Outbreak. Ophthalmology. 2021 09; 128(9):1346-1355. doi: 10.1016/j.ophtha.2021.03.009. [PMID: 33711379]
Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
Takeshi Miyake, Emi Kimoto, Lina Luo, Sumathy Mathialagan, Lauren M Horlbogen, Ragu Ramanathan, Linda S Wood, Jillian G Johnson, Vu H Le, Manoli Vourvahis, A David Rodrigues, Chieko Muto, Kenichi Furihata, Yuichi Sugiyama, Hiroyuki Kusuhara. Identification of Appropriate Endogenous Biomarker for Risk Assessment of Multidrug and Toxin Extrusion Protein-Mediated Drug-Drug Interactions in Healthy Volunteers. Clinical pharmacology and therapeutics. 2021 02; 109(2):507-516. doi: 10.1002/cpt.2022. [PMID: 32866300]
Ingrid Reiter-Owona, Harald Hlobil, Martin Enders, Ute Klarmann-Schulz, Barbara Gruetzmacher, Veronika Rilling, Achim Hoerauf, Justus G Garweg. Sulfadiazine plasma concentrations in women with pregnancy-acquired compared to ocular toxoplasmosis under pyrimethamine and sulfadiazine therapy: a case-control study. European journal of medical research. 2020 Nov; 25(1):59. doi: 10.1186/s40001-020-00458-7. [PMID: 33228795]
Xiyuan Yao, Noah H Watkins, Heather Brown-Harding, Ulrich Bierbach. A membrane transporter determines the spectrum of activity of a potent platinum-acridine hybrid anticancer agent. Scientific reports. 2020 09; 10(1):15201. doi: 10.1038/s41598-020-72099-z. [PMID: 32939009]
Mauricio A García, Danae Contreras, Pablo M González. Metformin Transport in Native MDCK-Wt and MDCK-II Monolayers Unveils Functional Inter-Strains Differences Influencing Drug Permeability. Pharmaceutical research. 2020 Jun; 37(7):121. doi: 10.1007/s11095-020-02824-w. [PMID: 32514792]
Stella Wanjiku Gikunju, Eric L Agola, Raphael Omusebe Ondondo, Johnson Kinyua, Francis Kimani, Angelle Desiree LaBeaud, Indu Malhotra, Charles King, Kelvin Thiong'o, Francis Mutuku. Prevalence of pfdhfr and pfdhps mutations in Plasmodium falciparum associated with drug resistance among pregnant women receiving IPTp-SP at Msambweni County Referral Hospital, Kwale County, Kenya. Malaria journal. 2020 May; 19(1):190. doi: 10.1186/s12936-020-03263-z. [PMID: 32448228]
Qiao Lu, Rongkun Lin, Chao Du, Yifan Meng, Manqing Yang, Renato Zenobi, Wei Hang. Metal Probe Microextraction Coupled to Dielectric Barrier Discharge Ionization-Mass Spectrometry for Detecting Drug Residues in Organisms. Analytical chemistry. 2020 04; 92(8):5921-5928. doi: 10.1021/acs.analchem.0c00004. [PMID: 32193924]
Wigilya P Mikomangwa, Omary Minzi, Ritah Mutagonda, Vito Baraka, Eulambius M Mlugu, Eleni Aklillu, Appolinary A R Kamuhabwa. Effect of sulfadoxine-pyrimethamine doses for prevention of malaria during pregnancy in hypoendemic area in Tanzania. Malaria journal. 2020 Apr; 19(1):160. doi: 10.1186/s12936-020-03234-4. [PMID: 32306955]
Gasper Maeda, Joan J E Munissi, Sofia Lindblad, Sandra Duffy, Jerry Pelletier, Vicky M Avery, Stephen S Nyandoro, Máté Erdélyi. A Meroisoprenoid, Heptenolides, and C-Benzylated Flavonoids from Sphaerocoryne gracilis ssp. gracilis. Journal of natural products. 2020 02; 83(2):316-322. doi: 10.1021/acs.jnatprod.9b00721. [PMID: 32067457]
Xiaoyue Sun, Shuyun Bi, Jun Wu, Rui Zhao, Di Shao, Zhe Song. Multispectral and molecular docking investigations on the interaction of primethamine/trimethoprim with BSA/HSA. Journal of biomolecular structure & dynamics. 2020 02; 38(3):934-942. doi: 10.1080/07391102.2019.1588785. [PMID: 30843766]
Jean Claude Djontu, Yukie Michelle Lloyd, Rosette Megnekou, Reine Medouen Ndeumou Seumko'o, Ali Salanti, Diane Wallace Taylor, Rose Gana Fomban Leke. Antibodies to full-length and the DBL5 domain of VAR2CSA in pregnant women after long-term implementation of intermittent preventive treatment in Etoudi, Cameroon. PloS one. 2020; 15(8):e0237671. doi: 10.1371/journal.pone.0237671. [PMID: 32797068]
Brandi K Torrevillas, Sarah M Garrison, Alexander J McKeeken, Dharmeshkumar Patel, James T Van Leuven, Nathaniel I Dizon, Karina I Rivas, Nicholas J Hathaway, Jeffrey A Bailey, John N Waitumbi, Carolyne M Kifude, Janet Oyieko, V Ann Stewart, Shirley Luckhart. Plasmodium falciparum DHFR and DHPS Mutations Are Associated With HIV-1 Co-Infection and a Novel DHPS Mutation I504T Is Identified in Western Kenya. Frontiers in cellular and infection microbiology. 2020; 10(?):600112. doi: 10.3389/fcimb.2020.600112. [PMID: 33324580]
Ngwene Hycentha Diengou, Samuel Nambile Cumber, Claude Ngwayu Nkfusai, Mbuh Salioh Mbinyui, Vecheusi Zennobia Viyoff, Fala Bede, Lilian Akwah, Joyce Mahlako Tsoka-Gwegweni, Anchang-Kimbi Judith. Factors associated with the uptake of intermittent preventive treatment of malaria in pregnancy in the Bamenda health districts, Cameroon. The Pan African medical journal. 2020; 35(?):42. doi: 10.11604/pamj.2020.35.42.17600. [PMID: 32499857]
Isabella Quakyi, Bernard Tornyigah, Pascal Houze, Kwadwo A Kusi, Nathaniel Coleman, Guillaume Escriou, Amos Laar, Michel Cot, Julius Fobil, Gloria Quansah Asare, Philippe Deloron, Abraham K Anang, Gilles Cottrell, Michael F Ofori, Nicaise Tuikue Ndam. High uptake of Intermittent Preventive Treatment of malaria in pregnancy is associated with improved birth weight among pregnant women in Ghana. Scientific reports. 2019 12; 9(1):19034. doi: 10.1038/s41598-019-55046-5. [PMID: 31836735]
João Cláudio da Costa Urbano, Ranny Beatriz de Carvalho Holanda Leite, Renan Leopoldo Pereira Castro, Clarice Maux Vianna da Silva, Joelma Maria de Araújo Andrade, Cláudio Bruno Silva de Oliveira, Vanessa Santos de Arruda Barbosa, Valter Ferreira de Andrade-Neto, Cecília Maria de Carvalho Xavier Holanda. Effect of toxoplasmic infection on the biodistribution of a brain radiopharmaceutical. International journal of radiation biology. 2019 11; 95(11):1547-1551. doi: 10.1080/09553002.2019.1642533. [PMID: 31290704]
Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
Andrew Teo, Louise M Randall, Mwayiwawo Madanitsa, Victor Mwapasa, Linda Kalilani Phiri, Carole Khairallah, Christelle Buffet, Amalia Karahalios, David L Narum, Feiko O Ter Kuile, Stephen J Rogerson. Intermittent screening and treatment with dihydroartemisinin-piperaquine and intermittent preventive therapy with sulfadoxine-pyrimethamine have similar effects on malaria antibody in pregnant Malawian women. Scientific reports. 2019 05; 9(1):7878. doi: 10.1038/s41598-019-44340-x. [PMID: 31133672]
Mahbobeh Montazeri, Saeed Emami, Hossein Asgarian-Omran, Soheil Azizi, Mehdi Sharif, Shahabeddin Sarvi, Fatemeh Rezaei, Mitra Sadeghi, Shaban Gohardehi, Ahmad Daryani. In vitro and in vivo evaluation of kojic acid against Toxoplasma gondii in experimental models of acute toxoplasmosis. Experimental parasitology. 2019 May; 200(?):7-12. doi: 10.1016/j.exppara.2019.03.009. [PMID: 30904693]
Luke P Robertson, Leonardo Lucantoni, Sandra Duffy, Vicky M Avery, Anthony R Carroll. Acrotrione: An Oxidized Xanthene from the Roots of Acronychia pubescens. Journal of natural products. 2019 04; 82(4):1019-1023. doi: 10.1021/acs.jnatprod.8b00956. [PMID: 30865443]
Holger W Unger, Annjaleen P Hansa, Christelle Buffet, Wina Hasang, Andrew Teo, Louise Randall, Maria Ome-Kaius, Stephan Karl, Ayen A Anuan, James G Beeson, Ivo Mueller, Sarah J Stock, Stephen J Rogerson. Sulphadoxine-pyrimethamine plus azithromycin may improve birth outcomes through impacts on inflammation and placental angiogenesis independent of malarial infection. Scientific reports. 2019 02; 9(1):2260. doi: 10.1038/s41598-019-38821-2. [PMID: 30783215]
Allen T Hopper, Adam Brockman, Andy Wise, Julie Gould, Jennifer Barks, Joshua B Radke, L David Sibley, Yongmao Zou, Stephen Thomas. Discovery of Selective Toxoplasma gondii Dihydrofolate Reductase Inhibitors for the Treatment of Toxoplasmosis. Journal of medicinal chemistry. 2019 02; 62(3):1562-1576. doi: 10.1021/acs.jmedchem.8b01754. [PMID: 30624926]
Michael Ramharter, Matthias Schwab, Ghyslain Mombo-Ngoma, Rella Zoleko Manego, Daisy Akerey-Diop, Arti Basra, Jean-Rodolphe Mackanga, Heike Würbel, Jan-Georg Wojtyniak, Raquel Gonzalez, Ute Hofmann, Mirjam Geditz, Pierre-Blaise Matsiegui, Peter G Kremsner, Clara Menendez, Reinhold Kerb, Thorsten Lehr. Population Pharmacokinetics of Mefloquine Intermittent Preventive Treatment for Malaria in Pregnancy in Gabon. Antimicrobial agents and chemotherapy. 2019 02; 63(2):. doi: 10.1128/aac.01113-18. [PMID: 30455233]
Abigail Ward, Andrea Guillot, Lyudmila E Nepomnyashchiy, Justin C Graves, Kathleen Maloney, Omowunmi F Omoniwa, Leslie Emegbuonye, Charles Opondo, Marko Kerac, Elizabeth Omoluabi, Antoinette Bhattacharya, Karen Milch Hariharan, Owens Wiwa, Justin M Cohen, Arnaud Le Menach. Seasonal malaria chemoprevention packaged with malnutrition prevention in northern Nigeria: A pragmatic trial (SMAMP study) with nested case-control. PloS one. 2019; 14(1):e0210692. doi: 10.1371/journal.pone.0210692. [PMID: 30682069]
Sarath P D Senadeera, Leonardo Lucantoni, Sandra Duffy, Vicky M Avery, Anthony R Carroll. Antiplasmodial β-Triketone-Flavanone Hybrids from the Flowers of the Australian Tree Corymbia torelliana. Journal of natural products. 2018 07; 81(7):1588-1597. doi: 10.1021/acs.jnatprod.8b00154. [PMID: 29969262]
Alassane Dicko, Michelle E Roh, Halimatou Diawara, Almahamoudou Mahamar, Harouna M Soumare, Kjerstin Lanke, John Bradley, Koualy Sanogo, Daouda T Kone, Kalifa Diarra, Sekouba Keita, Djibrilla Issiaka, Sekou F Traore, Charles McCulloch, Will J R Stone, Jimee Hwang, Olaf Müller, Joelle M Brown, Vinay Srinivasan, Chris Drakeley, Roly Gosling, Ingrid Chen, Teun Bousema. Efficacy and safety of primaquine and methylene blue for prevention of Plasmodium falciparum transmission in Mali: a phase 2, single-blind, randomised controlled trial. The Lancet. Infectious diseases. 2018 06; 18(6):627-639. doi: 10.1016/s1473-3099(18)30044-6. [PMID: 29422384]
Rong Shi, Yuanyuan Yang, Zhangyao Xu, Yan Dai, Min Zheng, Tianming Wang, Yuanyuan Li, Yueming Ma. Renal vectorial transport of berberine mediated by organic cation transporter 2 (OCT2) and multidrug and toxin extrusion proteins 1 (MATE1) in rats. Biopharmaceutics & drug disposition. 2018 Jan; 39(1):47-58. doi: 10.1002/bdd.2112. [PMID: 29065218]
Luke P Robertson, Sandra Duffy, Yun Wang, Dongdong Wang, Vicky M Avery, Anthony R Carroll. Pimentelamines A-C, Indole Alkaloids Isolated from the Leaves of the Australian Tree Flindersia pimenteliana. Journal of natural products. 2017 12; 80(12):3211-3217. doi: 10.1021/acs.jnatprod.7b00587. [PMID: 29236492]
Melissa D Conrad, Daniel Mota, Marissa Foster, Stephen Tukwasibwe, Jennifer Legac, Patrick Tumwebaze, Meghan Whalen, Abel Kakuru, Patience Nayebare, Erika Wallender, Diane V Havlir, Prasanna Jagannathan, Liusheng Huang, Francesca Aweeka, Moses R Kamya, Grant Dorsey, Philip J Rosenthal. Impact of Intermittent Preventive Treatment During Pregnancy on Plasmodium falciparum Drug Resistance-Mediating Polymorphisms in Uganda. The Journal of infectious diseases. 2017 11; 216(8):1008-1017. doi: 10.1093/infdis/jix421. [PMID: 28968782]
Robert Elsby, Stephen Chidlaw, Samuel Outteridge, Sarah Pickering, Amy Radcliffe, Rebecca Sullivan, Hayley Jones, Philip Butler. Mechanistic in vitro studies confirm that inhibition of the renal apical efflux transporter multidrug and toxin extrusion (MATE) 1, and not altered absorption, underlies the increased metformin exposure observed in clinical interactions with cimetidine, trimethoprim or pyrimethamine. Pharmacology research & perspectives. 2017 10; 5(5):. doi: 10.1002/prp2.357. [PMID: 28971610]
Sam Salman, Francesca Baiwog, Madhu Page-Sharp, Kay Kose, Harin A Karunajeewa, Ivo Mueller, Stephen J Rogerson, Peter M Siba, Kenneth F Ilett, Timothy M E Davis. Optimal antimalarial dose regimens for chloroquine in pregnancy based on population pharmacokinetic modelling. International journal of antimicrobial agents. 2017 Oct; 50(4):542-551. doi: 10.1016/j.ijantimicag.2017.05.011. [PMID: 28669839]
Abhisheak Sharma, Swati Jaiswal, Mahendra Shukla, Jawahar Lal. Effect of arteether and pyrimethamine coadministration on the pharmacokinetic and pharmacodynamic profile of ormeloxifene. Naunyn-Schmiedeberg's archives of pharmacology. 2017 Sep; 390(9):971-976. doi: 10.1007/s00210-017-1401-4. [PMID: 28689253]
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Dale J Lange, Mona Shahbazi, Vincenzo Silani, Albert C Ludolph, Jochen H Weishaupt, Senda Ajroud-Driss, Kara G Fields, Rahul Remanan, Stanley H Appel, Claudia Morelli, Alberto Doretti, Luca Maderna, Stefano Messina, Ulrike Weiland, Stefan L Marklund, Peter M Andersen. Pyrimethamine significantly lowers cerebrospinal fluid Cu/Zn superoxide dismutase in amyotrophic lateral sclerosis patients with SOD1 mutations. Annals of neurology. 2017 Jun; 81(6):837-848. doi: 10.1002/ana.24950. [PMID: 28480639]
Sarath P D Senadeera, Sandra Duffy, Vicky M Avery, Anthony R Carroll. Antiplasmodial β-triketones from the flowers of the Australian tree Angophora woodsiana. Bioorganic & medicinal chemistry letters. 2017 06; 27(11):2602-2607. doi: 10.1016/j.bmcl.2017.03.065. [PMID: 28400231]
Sam Salman, Francisca Baiwog, Madhu Page-Sharp, Susan Griffin, Harin A Karunajeewa, Ivo Mueller, Stephen J Rogerson, Peter M Siba, Kenneth F Ilett, Timothy M E Davis. Optimal Antimalarial Dose Regimens for Sulfadoxine-Pyrimethamine with or without Azithromycin in Pregnancy Based on Population Pharmacokinetic Modeling. Antimicrobial agents and chemotherapy. 2017 05; 61(5):. doi: 10.1128/aac.02291-16. [PMID: 28242669]
Maxime G Corral, Julie Leroux, Keith A Stubbs, Joshua S Mylne. Herbicidal properties of antimalarial drugs. Scientific reports. 2017 03; 7(?):45871. doi: 10.1038/srep45871. [PMID: 28361906]
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