Batyl (BioDeep_00000230841)

 

Secondary id: BioDeep_00000004095, BioDeep_00000019325, BioDeep_00000858642

PANOMIX_OTCML-2023


代谢物信息卡片


InChI=1/C21H44O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-24-20-21(23)19-22/h21-23H,2-20H2,1H3

化学式: C21H44O3 (344.329)
中文名称: 鲨肝醇, 甘油单酯
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 31.08%

分子结构信息

SMILES: CCCCCCCCCCCCCCCCCCOCC(CO)O
InChI: InChI=1S/C21H44O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-24-20-21(23)19-22/h21-23H,2-20H2,1H3

描述信息

Batilol is an alkylglycerol that is glycerol in which one of the primary hydroxy groups has been converted into the corresponding octadecyl ether. It is used in cosmetics as a stabilising ingredient and skin-conditioning agent.
Batyl alcohol is a natural product found in Lobophytum, Sarcophyton crassocaule, and other organisms with data available.
C26170 - Protective Agent > C797 - Radioprotective Agent
3-(Octadecyloxy)propane-1,2-diol is an endogenous metabolite.

同义名列表

77 个代谢物同义名

InChI=1/C21H44O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-24-20-21(23)19-22/h21-23H,2-20H2,1H3; 4-01-00-02758 (Beilstein Handbook Reference); (+/-)-3-(OCTADECYLOXY)-1,2-PROPANEDIOL; 1-(Octadecyloxy)-2,3-dihydroxypropane; 1,2-Propanediol, 3-(octadecyloxy)-; .alpha.-Octadecylether of glycerol; 3-(octadecyloxy)propane-1,2-diol; Glycerol alpha-Monostearyl Ether; alpha-Octadecylether of glycerol; 3-(Octadecyloxy)-1,2-propanediol; Monooctadecyl ether of glycerol; 3-octadecyloxy-propane-1,2-diol; rac-Glycerol 1-octadecyl ether; 3-octadecyloxypropane-1,2-diol; 3-Octadecyloxy-1,2-propanediol; Glycerine 1-monostearyl ether; rac- 1-O-N-Octadecyl glycerol; 3-octadecoxypropane-1,2-diol; Glycerol monooctadecyl ether; batyl alcohol, (DL)-isomer; Glyceryl-1-octadecyl ether; OGBUMNBNEWYMNJ-UHFFFAOYSA-; Glycerol 1-octadecyl ether; glyceryl 1-octadecyl ether; 1-O-Octadecyl-rac-glycerol; batyl alcohol, (S)-isomer; 1-O-octadecyl-sn-glycerol; batyl alcohol, (R)-isomer; Glycerides, C14-22 mono-; Glycerol octadecyl ether; C18:0 Glyceryl 1-ether; 4-Oxadocosane-1,2-diol; Stearyl monoglyceride; Batyl alcohol;Batilol; C18:0 Glyceryl 1-ethe; 1-O-octadecylglycerol; Batilolum [INN-Latin]; C14-22 Monoglycerides; 1, 3-(octadecyloxy)-; BATYL ALCOHOL [INCI]; 1-Octadecylglycerol; Batyl alcohol, 99\\%; BATYL ALCOHOL [MI]; MG(O-18:0/0:0/0:0); Spectrum4_001778; dl-Batyl alcohol; BATILOL [WHO-DD]; Spectrum5_000395; Spectrum2_001609; Spectrum3_000738; DL-Batylalcohol; UNII-39YR661C4U; Bathyl alcohol; Tox21_111515_1; DivK1c_001035; Batilol [INN]; WLN: Q1YQ1O18; Batyl alcohol; Batil alcohol; Tox21_111515; KBio3_001516; KBio2_002138; KBio1_001035; KBio2_004706; Batylalcohol; NCI60_002329; KBio2_007274; IDI1_001035; MG(O-18:0); 39YR661C4U; AI3-18451; Batilolum; MG O-18:0; Batilol; Batylol; Batyl; 1-O-Octadecyl-sn-glycerol



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

7 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ABCB1, APOE, AXIN2, GPX1, PEX7, PLA2G12A, RAC1
Peripheral membrane protein 1 GNPAT
Endoplasmic reticulum membrane 3 CD4, MFSD2A, RAC1
Mitochondrion membrane 1 ABCG2
Nucleus 3 APOE, AXIN2, RAC1
cytosol 6 AXIN2, GNPAT, GPX1, LEP, PEX7, RAC1
dendrite 2 APOE, RAC1
mitochondrial membrane 2 ABCG2, GNPAT
trans-Golgi network 1 RAC1
centrosome 1 AXIN2
nucleoplasm 1 ABCG2
Cell membrane 7 ABCB1, ABCG2, CD4, CD86, MFSD2A, RAC1, TNF
Lipid-anchor 1 RAC1
Cytoplasmic side 1 RAC1
lamellipodium 1 RAC1
ruffle membrane 1 RAC1
Multi-pass membrane protein 3 ABCB1, ABCG2, MFSD2A
Synapse 1 RAC1
cell cortex 1 RAC1
cell surface 5 ABCB1, ADIPOQ, CD86, EPO, TNF
glutamatergic synapse 2 APOE, RAC1
Golgi apparatus 1 APOE
Golgi membrane 1 INS
neuronal cell body 2 APOE, TNF
postsynapse 1 RAC1
Cytoplasm, cytosol 1 PEX7
plasma membrane 9 ABCB1, ABCG2, APOE, AXIN2, CD4, CD86, MFSD2A, RAC1, TNF
Membrane 7 ABCB1, ABCG2, APOE, CD86, GNPAT, MFSD2A, RAC1
apical plasma membrane 2 ABCB1, ABCG2
extracellular exosome 5 ABCB1, APOE, CD86, EPO, RAC1
endoplasmic reticulum 2 ADIPOQ, APOE
extracellular space 8 ADIPOQ, APOE, EPO, IGF1, IL10, INS, LEP, TNF
mitochondrion 1 GPX1
Single-pass type I membrane protein 2 CD4, CD86
Secreted 9 ADIPOQ, APOE, EPO, IGF1, IL10, INS, LEP, PLA2G12A, RAC1
extracellular region 10 ADIPOQ, APOE, EPO, IGF1, IL10, INS, LEP, PLA2G12A, RAC1, TNF
mitochondrial matrix 1 GPX1
centriolar satellite 1 CD86
external side of plasma membrane 3 CD4, CD86, TNF
Endosome, multivesicular body 1 APOE
Extracellular vesicle 1 APOE
Secreted, extracellular space, extracellular matrix 1 APOE
chylomicron 1 APOE
high-density lipoprotein particle 1 APOE
low-density lipoprotein particle 1 APOE
multivesicular body 1 APOE
very-low-density lipoprotein particle 1 APOE
dendritic spine 1 RAC1
beta-catenin destruction complex 1 AXIN2
cytoplasmic vesicle 1 RAC1
Early endosome 2 APOE, CD4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 2 ABCB1, ABCG2
Cell projection, lamellipodium 1 RAC1
Matrix side 1 GNPAT
Membrane raft 3 ABCG2, CD4, TNF
focal adhesion 1 RAC1
extracellular matrix 1 APOE
Peroxisome 2 GNPAT, PEX7
collagen trimer 1 ADIPOQ
Peroxisome matrix 1 PEX7
peroxisomal matrix 2 GNPAT, PEX7
peroxisomal membrane 2 GNPAT, PEX7
collagen-containing extracellular matrix 2 ADIPOQ, APOE
phagocytic cup 1 TNF
cytoskeleton 1 RAC1
cytoplasmic ribonucleoprotein granule 1 RAC1
Secreted, extracellular space 1 APOE
brush border membrane 1 ABCG2
blood microparticle 1 APOE
Recycling endosome membrane 1 RAC1
Endomembrane system 1 GNPAT
endosome lumen 1 INS
Cell projection, dendrite 1 RAC1
Melanosome 2 APOE, RAC1
cell body 1 EPO
Peroxisome membrane 1 GNPAT
exocytic vesicle 1 IGF1
secretory granule lumen 2 EPO, INS
secretory granule membrane 1 RAC1
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 APOE, CD4, INS
platelet alpha granule lumen 1 IGF1
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
clathrin-coated endocytic vesicle membrane 2 APOE, CD4
synaptic cleft 1 APOE
ficolin-1-rich granule membrane 1 RAC1
external side of apical plasma membrane 2 ABCB1, ABCG2
discoidal high-density lipoprotein particle 1 APOE
endocytic vesicle lumen 1 APOE
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 1 CD4
chylomicron remnant 1 APOE
intermediate-density lipoprotein particle 1 APOE
lipoprotein particle 1 APOE
multivesicular body, internal vesicle 1 APOE
NADPH oxidase complex 1 RAC1
alphav-beta3 integrin-IGF-1-IGF1R complex 1 IGF1
insulin-like growth factor binding protein complex 1 IGF1
insulin-like growth factor ternary complex 1 IGF1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Fabian Dorninger, Frédéric M Vaz, Hans R Waterham, Jan B van Klinken, Gerhard Zeitler, Sonja Forss-Petter, Johannes Berger, Christoph Wiesinger. Ether lipid transfer across the blood-brain and placental barriers does not improve by inactivation of the most abundant ABC transporters. Brain research bulletin. 2022 10; 189(?):69-79. doi: 10.1016/j.brainresbull.2022.08.006. [PMID: 35981629]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Yow Keat Tham, Kevin Huynh, Natalie A Mellett, Darren C Henstridge, Helen Kiriazis, Jenny Y Y Ooi, Aya Matsumoto, Natalie L Patterson, Junichi Sadoshima, Peter J Meikle, Julie R McMullen. Distinct lipidomic profiles in models of physiological and pathological cardiac remodeling, and potential therapeutic strategies. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2018 Mar; 1863(3):219-234. doi: 10.1016/j.bbalip.2017.12.003. [PMID: 29217479]
  • Aliki A Rasmiena, Christopher K Barlow, Nada Stefanovic, Kevin Huynh, Ricardo Tan, Arpeeta Sharma, Dedreia Tull, Judy B de Haan, Peter J Meikle. Plasmalogen modulation attenuates atherosclerosis in ApoE- and ApoE/GPx1-deficient mice. Atherosclerosis. 2015 Dec; 243(2):598-608. doi: 10.1016/j.atherosclerosis.2015.10.096. [PMID: 26545014]
  • Nancy E Braverman, Ann B Moser. Functions of plasmalogen lipids in health and disease. Biochimica et biophysica acta. 2012 Sep; 1822(9):1442-52. doi: 10.1016/j.bbadis.2012.05.008. [PMID: 22627108]
  • Julien Bouchoux, Frauke Beilstein, Thomas Pauquai, I Chiara Guerrera, Danielle Chateau, Nathalie Ly, Malik Alqub, Christophe Klein, Jean Chambaz, Monique Rousset, Jean-Marc Lacorte, Etienne Morel, Sylvie Demignot. The proteome of cytosolic lipid droplets isolated from differentiated Caco-2/TC7 enterocytes reveals cell-specific characteristics. Biology of the cell. 2011 Nov; 103(11):499-517. doi: 10.1042/bc20110024. [PMID: 21787361]
  • Diana Martín, María I Morán-Valero, Francisco J Señoráns, Guillermo Reglero, Carlos F Torres. In vitro intestinal bioaccessibility of alkylglycerols versus triacylglycerols as vehicles of butyric acid. Lipids. 2011 Mar; 46(3):277-85. doi: 10.1007/s11745-010-3520-2. [PMID: 21225371]
  • Pedro Brites, Ana Sofia Ferreira, Tiago Ferreira da Silva, Vera F Sousa, Ana R Malheiro, Marinus Duran, Hans R Waterham, Myriam Baes, Ronald J A Wanders. Alkyl-glycerol rescues plasmalogen levels and pathology of ether-phospholipid deficient mice. PloS one. 2011; 6(12):e28539. doi: 10.1371/journal.pone.0028539. [PMID: 22163031]
  • Anne-Laure Deniau, Paul Mosset, Frédérique Pédrono, Romain Mitre, Damien Le Bot, Alain B Legrand. Multiple beneficial health effects of natural alkylglycerols from shark liver oil. Marine drugs. 2010 Jul; 8(7):2175-84. doi: 10.3390/md8072175. [PMID: 20714431]
  • N Krishna, P Muralidhar, M Murali Krishna Kumar, D Venkata Rao, C H Bheemasankara Rao. A new sphingolipid from the gorgonian Junceella juncea of the Indian Ocean. Natural product research. 2004 Dec; 18(6):551-5. doi: 10.1080/14786410350001622031. [PMID: 15595613]
  • K Y Hostetler, J L Hammond, G D Kini, S E Hostetler, J R Beadle, K A Aldern, T C Chou, D D Richman, J W Mellors. In vitro anti-HIV-1 activity of sn-2-substituted 1-O-octadecyl-sn-glycero-3-phosphonoformate analogues and synergy with zidovudine. Antiviral chemistry & chemotherapy. 2000 May; 11(3):213-9. doi: 10.1177/095632020001100304. [PMID: 10901292]
  • B Xiwen, Y Lixin, M Junjie. Treatment of peripheral leukopenia after cadaveric kidney transplantation. Transplantation proceedings. 1996 Jun; 28(3):1631-2. doi: NULL. [PMID: 8658815]
  • H Taguchi, B Kosar-Hashemi, B Paal, N Yang, W L Armarego. Glyceryl-ether monooxygenase (EC 1.14.16.5): nature of the glyceryl-ether lipid substrates in aqueous buffer. Biological chemistry Hoppe-Seyler. 1994 May; 375(5):329-34. doi: 10.1515/bchm3.1994.375.5.329. [PMID: 8074806]
  • Y Lu, P Jiang. [Chemical constituents of Eupolyphaga sinensis Walker]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 1992 Aug; 17(8):487-9, 512. doi: . [PMID: 1482536]
  • A K Das, R D Holmes, G N Wilson, A K Hajra. Dietary ether lipid incorporation into tissue plasmalogens of humans and rodents. Lipids. 1992 Jun; 27(6):401-5. doi: 10.1007/bf02536379. [PMID: 1630273]
  • J Palmblad, J Samuelsson, J Brohult. Interactions between alkylglycerols and human neutrophil granulocytes. Scandinavian journal of clinical and laboratory investigation. 1990 Jun; 50(4):363-70. doi: 10.3109/00365519009091592. [PMID: 2168089]
  • G Schrakamp, C G Schalkwijk, R B Schutgens, R J Wanders, J M Tager, H van den Bosch. Plasmalogen biosynthesis in peroxisomal disorders: fatty alcohol versus alkylglycerol precursors. Journal of lipid research. 1988 Mar; 29(3):325-34. doi: 10.1016/s0022-2275(20)38538-2. [PMID: 3379344]
  • L Ahrné, D L Palmquist. Incorporation of [hydrogen-3] alkylglycerolether and [carbon-14] hexadecanol into bovine colostrum and milk lipids. Journal of dairy science. 1982 Oct; 65(10):1905-11. doi: 10.3168/jds.s0022-0302(82)82437-5. [PMID: 7174959]
  • H O Herrmann, G Gercken. Metabolism of 1-0-[1'-14C]octadecyl-sn-glycerol in Leishmania donovani promastigotes. Ether lipid synthesis and degradation of the ether bond. Molecular and biochemical parasitology. 1982 Feb; 5(2):65-76. doi: 10.1016/0166-6851(82)90042-1. [PMID: 7078578]
  • C Gabrielides, V M Kapoulas. Metabolism of alpha-glyceryl ethers by Crithidia fasciculata. I. Study of the in vivo degradation of exogenous chimyl and batyl alcohols. The Journal of protozoology. 1981 Nov; 28(4):441-7. doi: 10.1111/j.1550-7408.1981.tb05317.x. [PMID: 7320947]