pantoprazole (BioDeep_00000229724)
Main id: BioDeep_00000001555
human metabolite
代谢物信息卡片
pantoprazole
化学式: C16H15F2N3O4S (383.0751)
中文名称: 左旋泮托拉唑, 泮托拉唑
谱图信息:
最多检出来源 Homo sapiens(general) 77.78%
分子结构信息
SMILES: COC1=C(C(=NC=C1)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC(F)F)OC
InChI: InChI=1S/C16H15F2N3O4S/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16/h3-7,15H,8H2,1-2H3,(H,20,21)
描述信息
A - Alimentary tract and metabolism > A02 - Drugs for acid related disorders > A02B - Drugs for peptic ulcer and gastro-oesophageal reflux disease (gord) > A02BC - Proton pump inhibitors
C78276 - Agent Affecting Digestive System or Metabolism > C29701 - Anti-ulcer Agent > C29723 - Proton Pump Inhibitor
D005765 - Gastrointestinal Agents > D000897 - Anti-Ulcer Agents
D004791 - Enzyme Inhibitors > D054328 - Proton Pump Inhibitors
CONFIDENCE standard compound; EAWAG_UCHEM_ID 644
同义名列表
2 个代谢物同义名
数据库引用编号
42 个数据库交叉引用编号
- ChEBI: CHEBI:7915
- KEGG: C11806
- PubChem: 4679
- HMDB: HMDB05017
- DrugBank: DB00213
- ChEMBL: CHEMBL1502
- MeSH: Pantoprazole
- CAS: 142706-18-1
- CAS: 154644-14-1
- CAS: 102625-70-7
- MoNA: EA064411
- MoNA: EA064413
- MoNA: EA064456
- MoNA: EA064410
- MoNA: EA064463
- MoNA: EA064404
- MoNA: EA064412
- MoNA: EA064461
- MoNA: EA064453
- MoNA: EA064409
- MoNA: EA064452
- MoNA: EA064455
- MoNA: EA064457
- MoNA: EA064402
- MoNA: EA064459
- MoNA: EA064460
- MoNA: EA064406
- MoNA: EA064451
- MoNA: EA064462
- MoNA: EA064414
- MoNA: EA064408
- MoNA: EA064464
- MoNA: EA064403
- MoNA: EA064454
- MoNA: EA064405
- MoNA: EA064401
- MoNA: EA064407
- MoNA: EA064458
- PubChem: 13970
- NIKKAJI: J324.079G
- RefMet: Pantoprazole
- KNApSAcK: 7915
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Finnian Freeling, Dominic Armbruster, Karsten Nödler, Uwe Kunkel, Marco Scheurer, Jan Koschorreck, Thomas A Ternes. Metabolites are overlooked in environmental risk assessments and monitoring of pharmaceuticals: The case study of pantoprazole.
Water research.
2024 Jun; 256(?):121596. doi:
10.1016/j.watres.2024.121596. [PMID: 38685172] - Yue Ma, Shu Li, Hongxi Yang, Yuan Zhang, Huiping Li, Lihui Zhou, Jing Lin, Yanchun Chen, Yabing Hou, Xinyu Zhang, Tong Liu, Xin Zhou, Yaogang Wang. Acid suppressants use and risk of atherosclerotic cardiovascular disease in middle-aged and older adults.
Atherosclerosis.
2022 10; 358(?):47-54. doi:
10.1016/j.atherosclerosis.2022.09.001. [PMID: 36113328] - Keith Feldman, Gregory L Kearns, Robin E Pearce, Susan M Abdel-Rahman, James Steven Leeder, Alec Friesen, Vincent S Staggs, Andrea Gaedigk, Jaylene Weigel, Valentina Shakhnovich. Utility of the 13 C-pantoprazole breath test as a CYP2C19 phenotyping probe for children.
Clinical and translational science.
2022 05; 15(5):1155-1166. doi:
10.1111/cts.13232. [PMID: 35099109] - C Zeng, T Neogi, A T Chan, J Wei, D Misra, N Lu, H K Choi, G Lei, Y Zhang. Proton pump inhibitor therapy and risk of knee replacement surgery: a general population-based cohort study.
Osteoarthritis and cartilage.
2022 04; 30(4):559-569. doi:
10.1016/j.joca.2021.12.010. [PMID: 35031493] - Michael A Fawzy, Sherif A Maher, Mahmoud A El-Rehany, Nermeen N Welson, Nisreen K A Albezrah, Gaber El-Saber Batiha, Moustafa Fathy. Vincamine Modulates the Effect of Pantoprazole in Renal Ischemia/Reperfusion Injury by Attenuating MAPK and Apoptosis Signaling Pathways.
Molecules (Basel, Switzerland).
2022 Feb; 27(4):. doi:
10.3390/molecules27041383. [PMID: 35209172] - Michael Poppe, Christian Clodi, Christoph Schriefl, Matthias Mueller, Raute Sunder-Plaßmann, Birgit Reiter, Maximilian Rechenmacher, Wisse van Os, J G Coen van Hasselt, Michael Holzer, Harald Herkner, Michael Schwameis, Bernd Jilma, Christian Schoergenhofer, Christoph Weiser. Targeted temperature management after cardiac arrest is associated with reduced metabolism of pantoprazole - A probe drug of CYP2C19 metabolism.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Feb; 146(?):112573. doi:
10.1016/j.biopha.2021.112573. [PMID: 34959115] - Bhargavi V Desai, Misbah N Qadri, Bhavin A Vyas. Proton pump inhibitors and osteoporosis risk: exploring the role of TRPM7 channel.
European journal of clinical pharmacology.
2022 Jan; 78(1):35-41. doi:
10.1007/s00228-021-03237-3. [PMID: 34714373] - Michael A Fawzy, Sherif A Maher, Sally M Bakkar, Mahmoud A El-Rehany, Moustafa Fathy. Pantoprazole Attenuates MAPK (ERK1/2, JNK, p38)-NF-κB and Apoptosis Signaling Pathways after Renal Ischemia/Reperfusion Injury in Rats.
International journal of molecular sciences.
2021 Oct; 22(19):. doi:
10.3390/ijms221910669. [PMID: 34639009] - Eman Ghonaim, Sahar El-Haggar, Suzy Gohar. Possible protective effect of pantoprazole against cisplatin-induced nephrotoxicity in head and neck cancer patients: a randomized controlled trial.
Medical oncology (Northwood, London, England).
2021 Aug; 38(9):108. doi:
10.1007/s12032-021-01558-y. [PMID: 34357466] - Zhimin Chen, Fangliang Gan, Xiali Rao, Xiaoxiao Huang, Huafang Chen. Pharmacokinetics, Bioequivalence, and Safety Studies of Pantoprazole Sodium Enteric-Coated Tablets in Healthy Subjects.
Clinical pharmacology in drug development.
2021 05; 10(5):502-509. doi:
10.1002/cpdd.888. [PMID: 33128847] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Burcu Kaya, Halime Mualla Nizam, Arzu Velioglu, Deniz Filinte, Handan Kaya, Serhan Tuglular. Granulomatous Interstitial Nephritis Associated With Pantoprazole.
American journal of therapeutics.
2021 04; 29(1):e143-e146. doi:
10.1097/mjt.0000000000001368. [PMID: 33852474] - Jian Le, Yuehua Liao, Shengni Li, Xiujuan Chen, Zhanying Hong. High-throughput LC-MS/MS Method for Simultaneous Determination of Pantoprazole and Atorvastatin in Rat Plasma: Application to a Pharmacokinetic Interaction Study.
Current drug metabolism.
2021; 22(6):481-490. doi:
10.2174/1389200222666210520090632. [PMID: 34455944] - Ahmet Sevki Taskiran, Mustafa Ergul, Handan Gunes, Aysegul Ozturk, Bilal Sahin, Ercan Ozdemir. The Effects of Proton Pump Inhibitors (Pantoprazole) on Pentylenetetrazole-Induced Epileptic Seizures in Rats and Neurotoxicity in the SH-SY5Y Human Neuroblastoma Cell Line.
Cellular and molecular neurobiology.
2021 Jan; 41(1):173-183. doi:
10.1007/s10571-020-00956-6. [PMID: 32862257] - Taavi J K Kaartinen, Aleksi Tornio, Tuija Tapaninen, Terhi Launiainen, Nina Isoherranen, Mikko Niemi, Janne T Backman. Effect of High-Dose Esomeprazole on CYP1A2, CYP2C19, and CYP3A4 Activities in Humans: Evidence for Substantial and Long-lasting Inhibition of CYP2C19.
Clinical pharmacology and therapeutics.
2020 12; 108(6):1254-1264. doi:
10.1002/cpt.1949. [PMID: 32558923] - Syed Mohammed Basheeruddin Asdaq, Earla Swathi, Sunil S Dhamanigi, Mohammed Asad, Yahya Ali Mohzari, Ahmed A Alrashed, Abdulrahman S Alotaibi, Batool Mohammed Alhassan, Sreeharsha Nagaraja. Role of Daucus carota in Enhancing Antiulcer Profile of Pantoprazole in Experimental Animals.
Molecules (Basel, Switzerland).
2020 Nov; 25(22):. doi:
10.3390/molecules25225287. [PMID: 33202703] - Jae Ho Cho, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee. Efficacy of DA-5204 (Stillen 2X) for patients with gastroesophageal reflux disease: A randomized, double-blind, placebo-controlled pilot study.
Medicine.
2020 Oct; 99(44):e22729. doi:
10.1097/md.0000000000022729. [PMID: 33126310] - Gaurav Taneja, Punniyakoti V Thanikachalam, Satyendra K Rajput. Dose and time-dependent toxicological impact of pantoprazole on vascular endothelium and renal tissue.
Toxicology letters.
2020 Oct; 333(?):97-104. doi:
10.1016/j.toxlet.2020.07.031. [PMID: 32763312] - Doaa El-Bohy, Magdy El Sharkawy, Soheir Abo-Elazm, Sara Shahin, Waleed Bchari, Azza Mancy, Manal El Hamamsy. Esomeprazole vs pantoprazole effects on cyclosporine levels in kidney transplantation: A randomized clinical trial.
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy.
2020 Oct; 24(5):591-598. doi:
10.1111/1744-9987.13464. [PMID: 31856374] - Sara Blanco Dorado, Olalla Maroñas Amigo, Ana Latorre-Pellicer, María Teresa Rodríguez Jato, Ana López-Vizcaíno, Aurea Gómez Márquez, Belén Bardán García, Dolores Belles Medall, Gema Barbeito Castiñeiras, María Luisa Pérez Del Molino Bernal, Manuel Campos-Toimil, Francisco Otero Espinar, Andrés Blanco Hortas, Irene Zarra Ferro, Ángel Carracedo, María Jesús Lamas, Anxo Fernández-Ferreiro. A multicentre prospective study evaluating the impact of proton-pump inhibitors omeprazole and pantoprazole on voriconazole plasma concentrations.
British journal of clinical pharmacology.
2020 08; 86(8):1661-1666. doi:
10.1111/bcp.14267. [PMID: 32110830] - Andreas Kofoed, Anders Perner, Søren Marker, Nicolai Haase, Lars B Holst, Morten Hylander Møller. Effects of simulated sample sizes on the mortality effect estimates in three randomized intensive care unit trials.
Acta anaesthesiologica Scandinavica.
2020 08; 64(7):976-981. doi:
10.1111/aas.13585. [PMID: 32236941] - Lu-Ning Sun, Ye Zhang, Yu-Qing Yang, Ye Shen, Yu-Wen Ying, Yu-Wen Su, Xue-Hui Zhang, Yun Liu, Xu Huang, Yong-Qing Wang. Simultaneous enantioselective determination of omeprazole, rabeprazole, lansoprazole, and pantoprazole enantiomers in human plasma by chiral liquid chromatography-tandem mass spectrometry.
Journal of separation science.
2020 Aug; 43(16):3183-3196. doi:
10.1002/jssc.202000226. [PMID: 32495501] - Dolores Ochoa, Manuel Román, Teresa Cabaleiro, Miriam Saiz-Rodríguez, Gina Mejía, Francisco Abad-Santos. Effect of food on the pharmacokinetics of omeprazole, pantoprazole and rabeprazole.
BMC pharmacology & toxicology.
2020 07; 21(1):54. doi:
10.1186/s40360-020-00433-2. [PMID: 32711578] - Raed S Ismail, Mohammed S El-Awady, Memy H Hassan. Pantoprazole abrogated cisplatin-induced nephrotoxicity in mice via suppression of inflammation, apoptosis, and oxidative stress.
Naunyn-Schmiedeberg's archives of pharmacology.
2020 07; 393(7):1161-1171. doi:
10.1007/s00210-020-01823-3. [PMID: 31950223] - Felicitas Stoll, Antje Blank, Gerd Mikus, David Czock, Kathrin I Foerster, Simon Hermann, Katja Häußler, Amin Muhareb, Simone Hummler, Johanna Weiss, Jürgen Burhenne, Walter E Haefeli. Impact of pantoprazole on absorption and disposition of hydroxychloroquine, a drug used in Corona Virus Disease-19 (Covid-19): A structured summary of a study protocol for a randomised controlled trial.
Trials.
2020 Jun; 21(1):584. doi:
10.1186/s13063-020-04476-y. [PMID: 32600363] - Isabel J B van der Zalm, Tom J M Tobé, Susan J J Logtenberg. Omeprazole-induced and pantoprazole-induced asymptomatic hyponatremia: a case report.
Journal of medical case reports.
2020 Jun; 14(1):83. doi:
10.1186/s13256-020-02423-8. [PMID: 32594911] - Andrew Sunderland, Graeme Russ, Benedetta Sallustio, Matthew Cervelli, David Joyce, Esther Ooi, Gary Jeffrey, Neil Boudville, Aron Chakera, Gursharan Dogra, Doris Chan, Germaine Wong, Wai H Lim. Effect of the proton-pump Inhibitor pantoprazole on MycoPhenolic ACid exposure in kidney and liver transplant recipienTs (IMPACT study): a randomized trial.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2020 06; 35(6):1060-1070. doi:
10.1093/ndt/gfaa111. [PMID: 32516810] - Varun Vohra, Jeanna M Marraffa, Susan M Wojcik, William Eggleston. An assessment of urine THC immunoassay in healthy volunteers receiving an oral proton-pump inhibitor.
Clinical toxicology (Philadelphia, Pa.).
2020 06; 58(6):498-500. doi:
10.1080/15563650.2019.1662917. [PMID: 31566030] - Qi Huang, Qiong Liu, Tao Yin, Lin Hu, Hanjun Ding, Shao Liu, Yueping Jiang. Effect of proton pump inhibitors on voriconazole concentrations in Chinese patients with malignant hematological diseases.
European journal of clinical pharmacology.
2020 Jun; 76(6):833-842. doi:
10.1007/s00228-020-02841-z. [PMID: 32157329] - Ken Ogasawara, Bradley Vince, Christine Xu, Meng Zhang, Maria Palmisano, Gopal Krishna. A phase I study of the effect of repeated oral doses of pantoprazole on the pharmacokinetics of a single dose of fedratinib in healthy male subjects.
Cancer chemotherapy and pharmacology.
2020 05; 85(5):995-1001. doi:
10.1007/s00280-020-04074-4. [PMID: 32318809] - Lina A Dahabiyeh, Eman Y Abu-Rish, Mutasem O Taha. Inhibition of monoglyceride lipase by proton pump inhibitors: investigation using docking and in vitro experiments.
Pharmacological reports : PR.
2020 Apr; 72(2):435-442. doi:
10.1007/s43440-019-00013-0. [PMID: 32048247] - Martin Schnierer, Matej Samoš, Tomáš Bolek, Ingrid Škorňová, Lenka Nosáková, Peter Bánovčin, Peter Galajda, Ján Stasko, Peter Kubisz, Rudolf Hyrdel, Marián Mokáň. The Effect of Proton Pump Inhibitor Withdrawal on Dabigatran Etexilate Plasma Levels in Patients With Atrial Fibrillation: A Washout Study.
Journal of cardiovascular pharmacology.
2020 04; 75(4):333-335. doi:
10.1097/fjc.0000000000000791. [PMID: 31895873] - Maxim Kuzin, Georgios Schoretsanitis, Ekkehard Haen, Gerhard Dammann, Christoph Hiemke, Gerhard Gründer, Michael Paulzen. The Effects of Co-prescription of Pantoprazole on the Clozapine Metabolism.
Pharmacopsychiatry.
2020 Mar; 53(2):65-70. doi:
10.1055/a-1021-8827. [PMID: 31614374] - Bhuvanachandra Pasupuleti, Vamshikrishna Gone, Ravali Baddam, Raj Kumar Venisetty, Om Prakash Prasad. Clinical Impact of Co-medication of Levetiracetam and Clobazam with Proton Pump Inhibitors: A Drug Interaction Study.
Current drug metabolism.
2020; 21(2):126-131. doi:
10.2174/1389200221666200218121050. [PMID: 32067615] - Sara Kadkhodaei, Farideh Siavoshi, Alireza Foroumadi, Abdolfattah Sarrafnejad, Shadi Kolahdoozan. Proton Pump Inhibitor-Treated H. pylori Adjust Cell Envelope Fatty Acid and Cholesterol Content to Survive.
Archives of Iranian medicine.
2020 01; 23(1):7-14. doi:
. [PMID: 31910629] - Masoomeh Shaghaghi, Samaneh Rashtbari, Asma Abdollahi, Gholamreza Dehghan, Abolghasem Jouyban. A Sensitive, Simple and Direct Determination of Pantoprazole Based on a 'Turn off-on' Fluorescence Nanosensor by Using Terbium-1,10-phenanthroline-silver Nanoparticles.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2020; 36(11):1345-1352. doi:
10.2116/analsci.20p142. [PMID: 33177314] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Jie Ying, Liu-Cheng Li, Cui-Yun Wu, Zhen-Wei Yu, Lian-Di Kan. The status of proton pump inhibitor use: a prescription survey of 45 hospitals in China.
Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva.
2019 Oct; 111(10):738-743. doi:
10.17235/reed.2019.6155/2019. [PMID: 31373505] - Cüneyt Türkeş. A potential risk factor for paraoxonase 1: in silico and in-vitro analysis of the biological activity of proton-pump inhibitors.
The Journal of pharmacy and pharmacology.
2019 Oct; 71(10):1553-1564. doi:
10.1111/jphp.13141. [PMID: 31353473] - Aziz Eghbali, Atefeh Khalilpour, Hassan Taherahmadi, Bahador Bagheri. Pantoprazole reduces serum ferritin in patients with thalassemia major and intermedia: A randomized, controlled study.
Therapie.
2019 Oct; 74(5):507-512. doi:
10.1016/j.therap.2018.11.013. [PMID: 30704764] - Paul Moayyedi, John W Eikelboom, Jackie Bosch, Stuart J Connolly, Leanne Dyal, Olga Shestakovska, Darryl Leong, Sonia S Anand, Stefan Störk, Kelley R H Branch, Deepak L Bhatt, Peter B Verhamme, Martin O'Donnell, Aldo P Maggioni, Eva M Lonn, Leopoldo S Piegas, Georg Ertl, Matyas Keltai, Nancy Cook Bruns, Eva Muehlhofer, Gilles R Dagenais, Jae-Hyung Kim, Masatsugu Hori, P Gabriel Steg, Robert G Hart, Rafael Diaz, Marco Alings, Petr Widimsky, Alvaro Avezum, Jeffrey Probstfield, Jun Zhu, Yan Liang, Patricio Lopez-Jaramillo, Ajay K Kakkar, Alexander N Parkhomenko, Lars Ryden, Nana Pogosova, Antonio L Dans, Fernando Lanas, Patrick J Commerford, Christian Torp-Pedersen, Tomek J Guzik, Dragos Vinereanu, Andrew M Tonkin, Basil S Lewis, Camilo Felix, Khalid Yusoff, Kaj P Metsarinne, Keith A A Fox, Salim Yusuf. Safety of Proton Pump Inhibitors Based on a Large, Multi-Year, Randomized Trial of Patients Receiving Rivaroxaban or Aspirin.
Gastroenterology.
2019 09; 157(3):682-691.e2. doi:
10.1053/j.gastro.2019.05.056. [PMID: 31152740] - Qianqian Cai, Tianyu Zhao, Lianjun Zhang, Pan Zhao, Yajie Zhu, Haiyan Xu, Xiaohong Hou. A new strategy for extraction and depuration of pantoprazole in rat plasma: Vortex assisted dispersive micro-solid-phase extraction employing metal organic framework MIL-101(Cr) as sorbent followed by dispersive liquid-liquid microextraction based on solidification of a floating organic droplet.
Journal of pharmaceutical and biomedical analysis.
2019 Aug; 172(?):86-93. doi:
10.1016/j.jpba.2019.04.016. [PMID: 31029803] - Kevin Renfert, Wolfgang Rabsch, Angelika Fruth, Stephanie Speck, Michael Pees. The use of a salmonella bacteriophage in bearded dragons: application, passage time and reisolation.
Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere.
2019 Aug; 47(4):247-256. doi:
10.1055/a-0959-5528. [PMID: 31434125] - Parichehr Kohansal, Nazanin Rajai, Ahmad Reza Dehpour, Amir Rashidian, Hamed Shafaroodi. The protective effect of acute pantoprazole pretreatment on renal ischemia/reperfusion injury in rats.
Fundamental & clinical pharmacology.
2019 Aug; 33(4):405-411. doi:
10.1111/fcp.12451. [PMID: 30720886] - Sauzanne G Khalilieh, Ka Lai Yee, Rosa I Sanchez, Li Fan, Kate Vaynshteyn, Kathleen Deschamps, Maureen Martell, Heather R Jordan, Marian Iwamoto. A Study to Evaluate Doravirine Pharmacokinetics When Coadministered With Acid-Reducing Agents.
Journal of clinical pharmacology.
2019 08; 59(8):1093-1098. doi:
10.1002/jcph.1399. [PMID: 30817001] - Jun Liu, Guoliang Wang, Yan Liu, Lei Huang, Xiangang Xu, Jun Wang. Effects of Somatostatin Combined with Pantoprazole on Serum C-Reactive Protein and Intercellular Adhesion Molecule-1 in Severe Acute Pancreatitis.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.
2019 Jul; 29(7):683-684. doi:
10.29271/jcpsp.2019.07.683. [PMID: 31253226] - Tomáš Bolek, Matej Samoš, Lucia Stančiaková, Jela Ivanková, Ingrid Škorňová, Ján Staško, Peter Galajda, Peter Kubisz, Marián Mokáň. The Impact of Proton Pump Inhibition on Dabigatran Levels in Patients With Atrial Fibrillation.
American journal of therapeutics.
2019 May; 26(3):e308-e313. doi:
10.1097/mjt.0000000000000599. [PMID: 28452843] - Joerg C Schefold, Mette Krag, Søren Marker, Anders Perner, Jørn Wetterslev, Matt P Wise, Mark Borthwick, Stepani Bendel, Frederik Keus, Anne Berit Guttormsen, Theis Lange, Morten Hylander Møller. Outcomes of Prophylactic Pantoprazole in Adult Intensive Care Unit Patients Receiving Dialysis: Results of a Randomized Trial.
American journal of nephrology.
2019; 50(4):312-319. doi:
10.1159/000502732. [PMID: 31480045] - V Shakhnovich, S Abdel-Rahman, C A Friesen, J Weigel, R E Pearce, A Gaedigk, J S Leeder, G L Kearns. Lean body weight dosing avoids excessive systemic exposure to proton pump inhibitors for children with obesity.
Pediatric obesity.
2019 01; 14(1):. doi:
10.1111/ijpo.12459. [PMID: 30257076] - Jennifer L Powers, Natalie N Rasmussen, Dow Hurst, Frederick G Strathmann. Up in Smoke: Uncovering a Lack of Evidence for Proton Pump Inhibitors as a Source of Tetrahydrocannabinol Immunoassay False Positives.
Pain medicine (Malden, Mass.).
2018 11; 19(11):2196-2200. doi:
10.1093/pm/pnx266. [PMID: 29126183] - Wiebke Kempin, Vanessa Domsta, Iris Brecht, Beatrice Semmling, Susan Tillmann, Werner Weitschies, Anne Seidlitz. Development of a dual extrusion printing technique for an acid- and thermo-labile drug.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2018 Oct; 123(?):191-198. doi:
10.1016/j.ejps.2018.07.041. [PMID: 30031859] - Valentina Shakhnovich, P Brian Smith, Jeffrey T Guptill, Laura P James, David N Collier, Huali Wu, Chad E Livingston, Jian Zhao, Gregory L Kearns, Michael Cohen-Wolkowiez. A Population-Based Pharmacokinetic Model Approach to Pantoprazole Dosing for Obese Children and Adolescents.
Paediatric drugs.
2018 Oct; 20(5):483-495. doi:
10.1007/s40272-018-0305-1. [PMID: 30097906] - Ping-I Hsu, Chao-Yu Pan, John Y Kao, Feng-Woei Tsay, Nan-Jing Peng, Sung-Shuo Kao, Huay-Min Wang, Tzung-Jiun Tsai, Deng-Chyang Wu, Chien-Lin Chen, Kuo-Wang Tsai. Helicobacter pylori eradication with bismuth quadruple therapy leads to dysbiosis of gut microbiota with an increased relative abundance of Proteobacteria and decreased relative abundances of Bacteroidetes and Actinobacteria.
Helicobacter.
2018 Aug; 23(4):e12498. doi:
10.1111/hel.12498. [PMID: 29897654] - Elizabeth Fox, Kristin Levin, Yan Zhu, Blair Segers, Naomi Balamuth, Richard Womer, Rochelle Bagatell, Frank Balis. Pantoprazole, an Inhibitor of the Organic Cation Transporter 2, Does Not Ameliorate Cisplatin-Related Ototoxicity or Nephrotoxicity in Children and Adolescents with Newly Diagnosed Osteosarcoma Treated with Methotrexate, Doxorubicin, and Cisplatin.
The oncologist.
2018 07; 23(7):762-e79. doi:
10.1634/theoncologist.2018-0037. [PMID: 29445029] - Maxim Kuzin, Georgios Schoretsanitis, Ekkehard Haen, Benedikt Stegmann, Christoph Hiemke, Gerhard Gründer, Michael Paulzen. Effects of the Proton Pump Inhibitors Omeprazole and Pantoprazole on the Cytochrome P450-Mediated Metabolism of Venlafaxine.
Clinical pharmacokinetics.
2018 06; 57(6):729-737. doi:
10.1007/s40262-017-0591-8. [PMID: 28866861] - Tsuyoshi Karibe, Tomoki Imaoka, Koji Abe, Osamu Ando. Curcumin as an In Vivo Selective Intestinal Breast Cancer Resistance Protein Inhibitor in Cynomolgus Monkeys.
Drug metabolism and disposition: the biological fate of chemicals.
2018 05; 46(5):667-679. doi:
10.1124/dmd.117.078931. [PMID: 29358184] - Wiebke Kempin, Vanessa Domsta, Georg Grathoff, Iris Brecht, Beatrice Semmling, Susan Tillmann, Werner Weitschies, Anne Seidlitz. Immediate Release 3D-Printed Tablets Produced Via Fused Deposition Modeling of a Thermo-Sensitive Drug.
Pharmaceutical research.
2018 Apr; 35(6):124. doi:
10.1007/s11095-018-2405-6. [PMID: 29679157] - Seyit Uyar, Suleyman Dolu, Basak O Yolcular, Hamit Y Ellidag, Mehmet Kok, Feyzi Bostan, Yasin Sahinturk, Ayhan H Cekin. Short-Term Effect of High-Dose Pantoprazol on Serum and Urinary Magnesium Levels.
Clinical laboratory.
2018 Mar; 64(3):263-268. doi:
10.7754/clin.lab.2017.170822. [PMID: 29739099] - Hui-Wen Jiao, Lu-Ning Sun, Yue-Qi Li, Lei Yu, Hong-Wen Zhang, Mei-Feng Wang, Li-Yuan Yu, Zi-Qing-Yun Yuan, Li-Jun Xie, Juan Chen, Ling Meng, Xue-Hui Zhang, Yong-Qing Wang. Safety, pharmacokinetics, and pharmacodynamics of S-(-)-pantoprazole sodium injections after single and multiple intravenous doses in healthy Chinese subjects.
European journal of clinical pharmacology.
2018 Mar; 74(3):257-265. doi:
10.1007/s00228-017-2372-6. [PMID: 29167917] - Valentina Shakhnovich, P Brian Smith, Jeffrey T Guptill, Laura P James, David N Collier, Huali Wu, Chad E Livingston, Jian Zhao, Gregory L Kearns. Obese Children Require Lower Doses of Pantoprazole Than Nonobese Peers to Achieve Equal Systemic Drug Exposures.
The Journal of pediatrics.
2018 02; 193(?):102-108.e1. doi:
10.1016/j.jpeds.2017.10.011. [PMID: 29389444] - Christian Schoergenhofer, Eva-Luise Hobl, Peter Schellongowski, Gottfried Heinz, Walter S Speidl, Jolanta M Siller-Matula, Monika Schmid, Raute Sunder-Plaßmann, Thomas Stimpfl, Matthias Hackl, Bernd Jilma. Clopidogrel in Critically Ill Patients.
Clinical pharmacology and therapeutics.
2018 02; 103(2):217-223. doi:
10.1002/cpt.878. [PMID: 28913918] - Andrea Corsello, Luigi Di Filippo, Sara Massironi, Federica Sileo, Anna Dolcetta Capuzzo, Marco Gemma, Claudia Carlucci, Claudio Cusini, Barbara Colombo, Alice Dallatomasina, Giulia Maria Franchi, Angelo Corti, Marco Federico Manzoni. Vasostatin-1: A novel circulating biomarker for ileal and pancreatic neuroendocrine neoplasms.
PloS one.
2018; 13(5):e0196858. doi:
10.1371/journal.pone.0196858. [PMID: 29723285] - Mykola А Bychkov, Maryana М Yakhnitska. [Features of exchange of calcium saliva in patients with gastroesophageal reflux disease].
Wiadomosci lekarskie (Warsaw, Poland : 1960).
2018 ; 71(3 pt 1):561-563. doi:
. [PMID: 29783225] - Isabel Gomila, Bernardino Barceló, Antonio Rosell, Sonia Avella, Laura Sahuquillo, Macarena Dastis. Cross-Reactivity of Pantoprazole with Three Commercial Cannabinoids Immunoassays in Urine.
Journal of analytical toxicology.
2017 Nov; 41(9):760-764. doi:
10.1093/jat/bkx047. [PMID: 28985315] - Jie Zhou, Cun Li, Guangyu Zhao, Hin Chu, Dong Wang, Helen Hoi-Ning Yan, Vincent Kwok-Man Poon, Lei Wen, Bosco Ho-Yin Wong, Xiaoyu Zhao, Man Chun Chiu, Dong Yang, Yixin Wang, Rex K H Au-Yeung, Ivy Hau-Yee Chan, Shihui Sun, Jasper Fuk-Woo Chan, Kelvin Kai-Wang To, Ziad A Memish, Victor M Corman, Christian Drosten, Ivan Fan-Ngai Hung, Yusen Zhou, Suet Yi Leung, Kwok-Yung Yuen. Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus.
Science advances.
2017 11; 3(11):eaao4966. doi:
10.1126/sciadv.aao4966. [PMID: 29152574] - Guillem Pascual-Pasto, Nagore G Olaciregui, Javier A W Opezzo, Helena Castillo-Ecija, Maria Cuadrado-Vilanova, Sonia Paco, Ezequiel M Rivero, Monica Vila-Ubach, Camilo A Restrepo-Perdomo, Montserrat Torrebadell, Mariona Suñol, Paula Schaiquevich, Jaume Mora, Guillermo F Bramuglia, Guillermo L Chantada, Angel M Carcaboso. Increased delivery of chemotherapy to the vitreous by inhibition of the blood-retinal barrier.
Journal of controlled release : official journal of the Controlled Release Society.
2017 Oct; 264(?):34-44. doi:
10.1016/j.jconrel.2017.08.018. [PMID: 28830790] - Huiwen Jiao, Yueqi Li, Luning Sun, Hongwen Zhang, Liyuan Yu, Lei Yu, Ziqingyun Yuan, Lijun Xie, Juan Chen, Yongqing Wang. A chiral LC-MS/MS method for the enantioselective determination of R-(+)- and S-(-)-pantoprazole in human plasma and its application to a pharmacokinetic study of S-(-)-pantoprazole sodium injection.
Biomedical chromatography : BMC.
2017 Oct; 31(10):. doi:
10.1002/bmc.3980. [PMID: 28370240] - Annick Vanclooster, Cees van Deursen, Reggy Jaspers, David Cassiman, Ger Koek. Proton Pump Inhibitors Decrease Phlebotomy Need in HFE Hemochromatosis: Double-Blind Randomized Placebo-Controlled Trial.
Gastroenterology.
2017 09; 153(3):678-680.e2. doi:
10.1053/j.gastro.2017.06.006. [PMID: 28624580] - Dunwei Guo, Chaoyi Wang, Qiang Wang, Zhongpeng Qiao, Hua Tang. Pantoprazole blocks the JAK2/STAT3 pathway to alleviate skeletal muscle wasting in cancer cachexia by inhibiting inflammatory response.
Oncotarget.
2017 Jun; 8(24):39640-39648. doi:
10.18632/oncotarget.17387. [PMID: 28489606] - S Tommasi, D J Elliot, J A Hulin, B C Lewis, M McEvoy, A A Mangoni. Human dimethylarginine dimethylaminohydrolase 1 inhibition by proton pump inhibitors and the cardiovascular risk marker asymmetric dimethylarginine: in vitro and in vivo significance.
Scientific reports.
2017 06; 7(1):2871. doi:
10.1038/s41598-017-03069-1. [PMID: 28588208] - Maja Kostrzewska, Marzena Garley, Wioletta Ratajczak-Wrona, Ewa Jabłońska, Jacek Jamiołkowski, Andrzej Dabrowski. The effect of short-term oral treatment with omeprazole or pantoprazole on the function of polymorphonuclear neutrophils.
Canadian journal of physiology and pharmacology.
2017 Jun; 95(6):675-680. doi:
10.1139/cjpp-2016-0232. [PMID: 28177671] - Pakinaz Y Khashaba, Hassan Refat H Ali, Mohamed M El-Wekil. Simultaneous voltammetric analysis of anti-ulcer and D2-antagonist agents in binary mixture using redox sensor and their determination in human serum.
Materials science & engineering. C, Materials for biological applications.
2017 Jun; 75(?):733-741. doi:
10.1016/j.msec.2017.02.092. [PMID: 28415523] - Nobuko Hada, William Joseph Netzer, Fanny Belhassan, Lawrence Paul Wennogle, Sveinbjörn Gizurarson. Nose-to-brain transport of imatinib mesylate: A pharmacokinetic evaluation.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2017 May; 102(?):46-54. doi:
10.1016/j.ejps.2017.02.032. [PMID: 28238945] - P A Senior, A Koh, J Yau, S Imes, P Dinyari, A J Malcolm, P Light, A M J Shapiro. Sitagliptin plus pantoprazole can restore but not maintain insulin independence after clinical islet transplantation: results of a pilot study.
Diabetic medicine : a journal of the British Diabetic Association.
2017 02; 34(2):204-212. doi:
10.1111/dme.13131. [PMID: 27087519] - Lalehan Akyuz, Idris Sargin, Murat Kaya, Talip Ceter, Ilgaz Akata. A new pollen-derived microcarrier for pantoprazole delivery.
Materials science & engineering. C, Materials for biological applications.
2017 Feb; 71(?):937-942. doi:
10.1016/j.msec.2016.11.009. [PMID: 27987792] - R Ozgur Karaca, Said Kalkisim, Akif Altinbas, Serta Kilincalp, Ilhami Yuksel, Mustafa T Goktas, Umit Yasar, Atilla Bozkurt, Melih O Babaoglu. Effects of Genetic Polymorphisms of Cytochrome P450 Enzymes and MDR1 Transporter on Pantoprazole Metabolism and Helicobacter pylori Eradication.
Basic & clinical pharmacology & toxicology.
2017 Feb; 120(2):199-206. doi:
10.1111/bcpt.12667. [PMID: 27611887] - Daniel S Strand, Daejin Kim, David A Peura. 25 Years of Proton Pump Inhibitors: A Comprehensive Review.
Gut and liver.
2017 Jan; 11(1):27-37. doi:
10.5009/gnl15502. [PMID: 27840364] - Erick V S Motta, Marivane Lemos, Juliana C Costa, Vilmar C Banderó-Filho, Astrid Sasse, Helen Sheridan, Jairo K Bastos. Galloylquinic acid derivatives from Copaifera langsdorffii leaves display gastroprotective activity.
Chemico-biological interactions.
2017 Jan; 261(?):145-155. doi:
10.1016/j.cbi.2016.11.028. [PMID: 27894855] - Devendra Pratap Singh, Swapnil P Borse, Manish Nivsarkar. Co-administration of quercetin with pantoprazole sodium prevents NSAID-induced severe gastroenteropathic damage efficiently: Evidence from a preclinical study in rats.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.
2017 Jan; 69(1):17-26. doi:
10.1016/j.etp.2016.10.004. [PMID: 27780667] - Agnieszka Matuszewska, Beata Nowak, Marta Rzeszutko, Krzysztof Zduniak, Marta Szandruk, Diana Jędrzejuk, Marcin Landwójtowicz, Marek Bolanowski, Małgorzata Pieśniewska, Joanna Kwiatkowska, Adam Szeląg. Effects of long-term administration of pantoprazole on bone mineral density in young male rats.
Pharmacological reports : PR.
2016 Oct; 68(5):1060-4. doi:
10.1016/j.pharep.2016.06.012. [PMID: 27552060] - J Huguet, J Lu, F Gaudette, J-L Chiasson, P Hamet, V Michaud, J Turgeon. No effects of pantoprazole on the pharmacokinetics of rosuvastatin in healthy subjects.
European journal of clinical pharmacology.
2016 Aug; 72(8):925-31. doi:
10.1007/s00228-016-2065-6. [PMID: 27146814] - Shengni Li, Huafang Jiang, Yiya Wang, Yinli Liu, Xiaohang Shen, Wenzhong Liang, Zhanying Hong. High-Throughput Chiral LC-MS/MS Method Using Overlapping Injection Mode for the Determination of Pantoprazole Enantiomers in Human Plasma with Application to Pharmacokinetic Study.
Chirality.
2016 07; 28(7):569-75. doi:
10.1002/chir.22616. [PMID: 27349958] - Xiaoyu Zeng, Lin Liu, Mengzhu Zheng, Huimin Sun, Juanjuan Xiao, Tao Lu, Guangqian Huang, Pianpian Chen, Jianmin Zhang, Feng Zhu, Hua Li, Qiuhong Duan. Pantoprazole, an FDA-approved proton-pump inhibitor, suppresses colorectal cancer growth by targeting T-cell-originated protein kinase.
Oncotarget.
2016 Apr; 7(16):22460-73. doi:
10.18632/oncotarget.7984. [PMID: 26967058] - Olga Kruszelnicka, Jolanta Świerszcz, Jacek Bednarek, Bernadeta Chyrchel, Andrzej Surdacki, Jadwiga Nessler. Asymmetric Dimethylarginine versus Proton Pump Inhibitors Usage in Patients with Stable Coronary Artery Disease: A Cross-Sectional Study.
International journal of molecular sciences.
2016 Apr; 17(4):454. doi:
10.3390/ijms17040454. [PMID: 27092494] - Mark Wagener. Haemotoxic snakebite in rural KwaZulu-Natal, South Africa: A case presenting with haematemesis.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.
2016 Mar; 106(5):44-5. doi:
10.7196/samj.2016.v106i5.9124. [PMID: 27138661] - Devendra Pratap Singh, Swapnil P Borse, Manish Nivsarkar. A novel model for NSAID induced gastroenteropathy in rats.
Journal of pharmacological and toxicological methods.
2016 Mar; 78(?):66-75. doi:
10.1016/j.vascn.2015.11.008. [PMID: 26655077] - Ayşegül Aksoy Gökmen, Nogay Girginkardeşler, Ali Ahmet Kilimcioğlu, Mümtaz Cem Şirin, Ahmet Özbilgin. [In vitro susceptibility of Trichomonas vaginalis to metronidazole, ornidazole and proton pump inhibitors pantoprazole and esomeprazole].
Mikrobiyoloji bulteni.
2016 Jan; 50(1):133-9. doi:
. [PMID: 27058337] - Ali Sigaroudi, Christoph Stelzer, Tina Braun, Sebastian Frechen, Sven Hüttner, Michael Schröter, Martina Kinzig, Uwe Fuhr, Ulrike Holzgrabe, Fritz Sörgel. Comparison of Pantoprazole Concentrations in Simultaneous Cerebrospinal Fluid and Serum Samples.
Pharmacology.
2016; 98(1-2):70-2. doi:
10.1159/000445720. [PMID: 27104875] - M L Becker, W P J Franken, F Karapinar, R Verzijl-Zeegers, T Schalekamp, R T M van der Hoeven. Possible drug-drug interaction between high-dose esomeprazole and phenprocoumon.
European journal of clinical pharmacology.
2015 Dec; 71(12):1461-5. doi:
10.1007/s00228-015-1912-1. [PMID: 26400679] - Edouard Ollier, Sophie Hodin, Thierry Basset, Sandrine Accassat, Laurent Bertoletti, Patrick Mismetti, Xavier Delavenne. In vitro and in vivo evaluation of drug-drug interaction between dabigatran and proton pump inhibitors.
Fundamental & clinical pharmacology.
2015 Dec; 29(6):604-14. doi:
10.1111/fcp.12154. [PMID: 26392328] - Natalie Bordag, Sebastian Klie, Kathrin Jürchott, Janine Vierheller, Hajo Schiewe, Valerie Albrecht, Jörg-Christian Tonn, Christoph Schwartz, Christian Schichor, Joachim Selbig. Glucocorticoid (dexamethasone)-induced metabolome changes in healthy males suggest prediction of response and side effects.
Scientific reports.
2015 Nov; 5(?):15954. doi:
10.1038/srep15954. [PMID: 26526738] - Julien Evrard, Elodie Farnier, Corine Carcel, Florence Lachenal, Thierry Vial, Emmanuelle Pont. [Proton Pump Inhibitor and High-dose Methotrexate: Two Cases Reports].
Therapie.
2015 Nov; 70(6):527-35. doi:
10.2515/therapie/2015047. [PMID: 26242498] - Olesja Rissling, Petra Glander, Pia Hambach, Marco Mai, Susanne Brakemeier, Daniela Klonower, Fabian Halleck, Eugenia Singer, Eva-Vanessa Schrezenmeier, Michael Dürr, Hans-Hellmut Neumayer, Klemens Budde. No relevant pharmacokinetic interaction between pantoprazole and mycophenolate in renal transplant patients: a randomized crossover study.
British journal of clinical pharmacology.
2015 Nov; 80(5):1086-96. doi:
10.1111/bcp.12664. [PMID: 25913040] - Jie Xing, Meitong Zang, Haiying Zhang, Mingshe Zhu. The application of high-resolution mass spectrometry-based data-mining tools in tandem to metabolite profiling of a triple drug combination in humans.
Analytica chimica acta.
2015 Oct; 897(?):34-44. doi:
10.1016/j.aca.2015.09.034. [PMID: 26515003] - Ferdane Sapmaz, Ismail H Kalkan, Incilay Suslu, Hüseyin Demirci, Pinar Atasoy, Sefa Guliter. Lower plasma pantoprazole level predicts Helicobacter pylori treatment failure in patients with type 2 diabetes mellitus.
Journal of digestive diseases.
2015 Sep; 16(9):531-6. doi:
10.1111/1751-2980.12272. [PMID: 26147605] - Akhileshwar K Srivastava, Mallika Tewari, Hari S Shukla, Bijoy K Roy. In Silico Profiling of the Potentiality of Curcumin and Conventional Drugs for CagA Oncoprotein Inactivation.
Archiv der Pharmazie.
2015 Aug; 348(8):548-55. doi:
10.1002/ardp.201400438. [PMID: 25996140] - Fathalla Belal, Mohie Sharaf El-Din, Manar M Tolba, Heba Alaa. Enhanced spectrofluorimetric determination of esomeprazole and pantoprazole in dosage forms and spiked human plasma using organized media.
Luminescence : the journal of biological and chemical luminescence.
2015 May; 30(3):343-51. doi:
10.1002/bio.2737. [PMID: 25060291] - Arvind Kumar Giri, Jitendra Kumar Rawat, Manjari Singh, Swetlana Gautam, Gaurav Kaithwas. Effect of lycopene against gastroesophageal reflux disease in experimental animals.
BMC complementary and alternative medicine.
2015 Apr; 15(?):110. doi:
10.1186/s12906-015-0631-6. [PMID: 25888837] - Diana Felton, Naamah Zitomersky, Shannon Manzi, Jenifer R Lightdale. 13-year-old girl with recurrent, episodic, persistent vomiting: out of the pot and into the fire.
Pediatrics.
2015 Apr; 135(4):e1060-3. doi:
10.1542/peds.2014-2116. [PMID: 25733759]
