Pantothenic Acid (BioDeep_00000229614)

Main id: BioDeep_00000000742

 

human metabolite PANOMIX_OTCML-2023


代谢物信息卡片


D-(+)-pantothenic acid

化学式: C9H17NO5 (219.11066720000002)
中文名称: 泛酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)(CO)C(C(=O)NCCC(=O)O)O
InChI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13)/t7-/m0/s1

描述信息

D018977 - Micronutrients > D014815 - Vitamins
D-Pantothenic acid (Pantothenate) is an essential trace nutrient that functions as the obligate precursor of coenzyme A (CoA). D-Pantothenic acid plays key roles in myriad biological processes, including many that regulate carbohydrate, lipid, protein, and nucleic acid metabolism[1].
D-Pantothenic acid (Pantothenate) is an essential trace nutrient that functions as the obligate precursor of coenzyme A (CoA). D-Pantothenic acid plays key roles in myriad biological processes, including many that regulate carbohydrate, lipid, protein, and nucleic acid metabolism[1].

同义名列表

5 个代谢物同义名

D-(+)-pantothenic acid; D-Pantothenic acid; Pantothenic Acid; Pantothenate; Vitamin B5



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yangyang Sun, Yutong Zhou, Qiyuan Long, Junwei Xing, Peizhen Guo, Yanchen Liu, Changjian Zhang, Yuanyuan Zhang, Alisdair R Fernie, Yuheng Shi, Yuehua Luo, Jie Luo, Cheng Jin. OsBCAT2, a gene responsible for the degradation of branched-chain amino acids, positively regulates salt tolerance by promoting the synthesis of vitamin B5. The New phytologist. 2024 Mar; 241(6):2558-2574. doi: 10.1111/nph.19551. [PMID: 38258425]
  • Richard Miallot, Virginie Millet, Franck Galland, Philippe Naquet. The vitamin B5/coenzyme A axis: A target for immunomodulation?. European journal of immunology. 2023 Jul; ?(?):e2350435. doi: 10.1002/eji.202350435. [PMID: 37482959]
  • H U Xingyao, Liu Hongning, Yan Xiaojun, Chen Zhong, F U Liu, Liu Ge, Chen Xuan, Shang Guangbin. Liver metabolomic characteristics in three different rat models of deficiency based on ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2023 Apr; 43(2):274-285. doi: 10.19852/j.cnki.jtcm.20230201.001. [PMID: 36994515]
  • Paria Asadi, Miroslav P Milev, Djenann Saint-Dic, Chiara Gamberi, Michael Sacher. Vitamin B5, a coenzyme A precursor, rescues TANGO2 deficiency disease-associated defects in Drosophila and human cells. Journal of inherited metabolic disease. 2023 03; 46(2):358-368. doi: 10.1002/jimd.12579. [PMID: 36502486]
  • Min Li, Baodian Guo, Fengquan Liu, Zheng Qing Fu. Cross-kingdom vitamin B5 biosynthesis and cyst nematode susceptibility. Trends in parasitology. 2023 Jan; 39(1):7-9. doi: 10.1016/j.pt.2022.11.004. [PMID: 36443162]
  • Shahid Siddique, Zoran S Radakovic, Clarissa Hiltl, Clement Pellegrin, Thomas J Baum, Helen Beasley, Andrew F Bent, Oliver Chitambo, Divykriti Chopra, Etienne G J Danchin, Eric Grenier, Samer S Habash, M Shamim Hasan, Johannes Helder, Tarek Hewezi, Julia Holbein, Martijn Holterman, Sławomir Janakowski, Georgios D Koutsovoulos, Olaf P Kranse, Jose L Lozano-Torres, Tom R Maier, Rick E Masonbrink, Badou Mendy, Esther Riemer, Mirosław Sobczak, Unnati Sonawala, Mark G Sterken, Peter Thorpe, Joris J M van Steenbrugge, Nageena Zahid, Florian Grundler, Sebastian Eves-van den Akker. The genome and lifestage-specific transcriptomes of a plant-parasitic nematode and its host reveal susceptibility genes involved in trans-kingdom synthesis of vitamin B5. Nature communications. 2022 10; 13(1):6190. doi: 10.1038/s41467-022-33769-w. [PMID: 36261416]
  • Yong Pu, Elvis Ticiani, Anita A Waye, Kunzhe Dong, Huanmin Zhang, Almudena Veiga-Lopez. Sex-specific extracellular matrix remodeling during early adipogenic differentiation by gestational bisphenol A exposure. Chemosphere. 2022 Sep; 302(?):134806. doi: 10.1016/j.chemosphere.2022.134806. [PMID: 35504463]
  • Christian C Dibble, Samuel A Barritt, Grace E Perry, Evan C Lien, Renee C Geck, Sarah E DuBois-Coyne, David Bartee, Thomas T Zengeya, Emily B Cohen, Min Yuan, Benjamin D Hopkins, Jordan L Meier, John G Clohessy, John M Asara, Lewis C Cantley, Alex Toker. PI3K drives the de novo synthesis of coenzyme A from vitamin B5. Nature. 2022 08; 608(7921):192-198. doi: 10.1038/s41586-022-04984-8. [PMID: 35896750]
  • Azibe Yildiz, Tugba Demiralp, Nigar Vardi, Gul Otlu, Elif Taslidere, Hilal Cirik, Elif Gurel. Protective effects of dexpanthenol in carbon tetrachloride-induced myocardial toxicity in rats. Tissue & cell. 2022 Aug; 77(?):101824. doi: 10.1016/j.tice.2022.101824. [PMID: 35653907]
  • Yuan Hong, Ziyi Zhou, Nan Zhang, Qiangqiang He, Zhangyou Guo, Lishun Liu, Yun Song, Ping Chen, Yaping Wei, Qiuyue Xu, Ya Li, Binyan Wang, Xianhui Qin, Xiping Xu, Yong Duan. Association between plasma Vitamin B5 levels and all-cause mortality: A nested case-control study. Journal of clinical hypertension (Greenwich, Conn.). 2022 07; 24(7):945-954. doi: 10.1111/jch.14516. [PMID: 35699663]
  • Xi Zhao, Siquan Zhang, Hongyi Shao. Dexpanthenol attenuates inflammatory damage and apoptosis in kidney and liver tissues of septic mice. Bioengineered. 2022 05; 13(5):11625-11635. doi: 10.1080/21655979.2022.2070585. [PMID: 35510377]
  • Tess Holling, Sheela Nampoothiri, Bedirhan Tarhan, Pauline E Schneeberger, Kollencheri Puthenveettil Vinayan, Dhanya Yesodharan, Arun Grace Roy, Periyasamy Radhakrishnan, Malik Alawi, Lindsay Rhodes, Katta Mohan Girisha, Peter B Kang, Kerstin Kutsche. Novel biallelic variants expand the SLC5A6-related phenotypic spectrum. European journal of human genetics : EJHG. 2022 04; 30(4):439-449. doi: 10.1038/s41431-021-01033-2. [PMID: 35013551]
  • Neslihan Pınar, Meyli Topaloğlu, İlke Evrim Seçinti, Esra Büyük, Mahir Kaplan. Protective effect of dexpanthenol on cisplatin induced nephrotoxicity in rats. Biotechnic & histochemistry : official publication of the Biological Stain Commission. 2022 Jan; 97(1):39-43. doi: 10.1080/10520295.2021.1890215. [PMID: 33632031]
  • Melanie Bourgin, Oliver Kepp, Guido Kroemer. Immunostimulatory effects of vitamin B5 improve anticancer immunotherapy. Oncoimmunology. 2022; 11(1):2031500. doi: 10.1080/2162402x.2022.2031500. [PMID: 35096488]
  • Shanping Wang, Keai Sinn Tan, Huimin Beng, Fei Liu, Jiandong Huang, Yihe Kuai, Rui Zhang, Wen Tan. Protective effect of isosteviol sodium against LPS-induced multiple organ injury by regulating of glycerophospholipid metabolism and reducing macrophage-driven inflammation. Pharmacological research. 2021 10; 172(?):105781. doi: 10.1016/j.phrs.2021.105781. [PMID: 34302975]
  • Yuping Liu, Siting Pan, Xinshuai Zhang, Hua Huang. In Vitro Reconstitution of the Pantothenic Acid Degradation Pathway in Ochrobactrum anthropi. ACS chemical biology. 2021 08; 16(8):1350-1353. doi: 10.1021/acschembio.1c00492. [PMID: 34313416]
  • Arif Aydın, Mehmet Giray Sönmez, Gökhan Ecer, Fahriye Kılınç, Rahim Kocabaş, Adeviye Elçi Atılgan, Pembe Oltulu, Mehmet Balasar. The effect of intratesticular dexpanthenol on experimentally-induced testicular ischaemia/reperfusion injury. Journal of pediatric urology. 2021 08; 17(4):440.e1-440.e7. doi: 10.1016/j.jpurol.2021.03.031. [PMID: 33883095]
  • Stephanie Kim, Eric Reed, Stefano Monti, Jennifer J Schlezinger. A Data-Driven Transcriptional Taxonomy of Adipogenic Chemicals to Identify White and Brite Adipogens. Environmental health perspectives. 2021 07; 129(7):77006. doi: 10.1289/ehp6886. [PMID: 34323617]
  • Jing Tang, Yulong Feng, Bo Zhang, Yongbao Wu, Zhanbao Guo, Suyun Liang, Zhengkui Zhou, Ming Xie, Shuisheng Hou. Severe pantothenic acid deficiency induces alterations in the intestinal mucosal proteome of starter Pekin ducks. BMC genomics. 2021 Jun; 22(1):491. doi: 10.1186/s12864-021-07820-x. [PMID: 34193047]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Sara Jiménez-Jiménez, Georgiana Amariei, Karina Boltes, María Ángeles García, María Luisa Marina. Enantiomeric separation of panthenol by Capillary Electrophoresis. Analysis of commercial formulations and toxicity evaluation on non-target organisms. Journal of chromatography. A. 2021 Feb; 1639(?):461919. doi: 10.1016/j.chroma.2021.461919. [PMID: 33535114]
  • Aitor Benedicto, Iera Hernandez-Unzueta, Eduardo Sanz, Joana Márquez. Ocoxin Increases the Antitumor Effect of BRAF Inhibition and Reduces Cancer Associated Fibroblast-Mediated Chemoresistance and Protumoral Activity in Metastatic Melanoma. Nutrients. 2021 Feb; 13(2):. doi: 10.3390/nu13020686. [PMID: 33669949]
  • Anis Irawan Anwar, Anni Adriani, Sri Rimayani, Asvira Anis Anwar, Arifin Seweng, Rina Munirah, We Sagara Dewi, Ivan Kurniadi. The Effectiveness of Galactomyces Ferment Filtrate, Dexpanthenol, and Centella Asiatica Combination Serum in the Treatment of Post-Acne Hyperpigmentation in Subjects with Skin of Color. Skinmed. 2021; 19(2):110-115. doi: NULL. [PMID: 33938432]
  • Aitor Benedicto, Eduardo Sanz, Joana Márquez. Ocoxin as a complement to first line treatments in cancer. International journal of medical sciences. 2021; 18(3):835-845. doi: 10.7150/ijms.50122. [PMID: 33437220]
  • T Aslan, E M Guler, A Cakir, T Dundar, A S Gulgec, O Huseyinbas, M Celikten, G Coban, I N Hakyemez, A Kocyigit, B Durdu. Dexpanthenol and ascorbic acid ameliorate colistin-induced nephrotoxicity in rats. European review for medical and pharmacological sciences. 2021 01; 25(2):1016-1023. doi: 10.26355/eurrev_202101_24671. [PMID: 33577057]
  • Giulio Auciello, Annalise Di Marco, Odalys Gonzalez Paz, Savina Malancona, Steven Harper, Maria Beconi, Ilaria Rossetti, Alina Ciammaichella, Paola Fezzardi, Andrea Vecchi, Elena Bracacel, Daniel Cicero, Edith Monteagudo, Daniel Elbaum. Cyclic Phosphopantothenic Acid Prodrugs for Treatment of Pantothenate Kinase-Associated Neurodegeneration. Journal of medicinal chemistry. 2020 12; 63(24):15785-15801. doi: 10.1021/acs.jmedchem.0c01531. [PMID: 33320012]
  • Tao Ma, Tonghua Liu, Peifeng Xie, Sheng Jiang, Wenming Yi, Pei Dai, Xiangyu Guo. UPLC-MS-based urine nontargeted metabolic profiling identifies dysregulation of pantothenate and CoA biosynthesis pathway in diabetic kidney disease. Life sciences. 2020 Oct; 258(?):118160. doi: 10.1016/j.lfs.2020.118160. [PMID: 32730837]
  • Jing Tang, Bo Zhang, Suyun Liang, Yongbao Wu, Yulong Feng, Zhanbao Guo, Guangnan Xing, Jinglin Jiao, Zhengkui Zhou, Ming Xie, Shuisheng Hou. Effects of pantothenic acid on growth performance and antioxidant status of growing male white Pekin ducks. Poultry science. 2020 Sep; 99(9):4436-4441. doi: 10.1016/j.psj.2020.05.021. [PMID: 32867987]
  • Atanasio Pandiella-Alonso, Elena Díaz-Rodríguez, Eduardo Sanz. Antitumoral Properties of the Nutritional Supplement Ocoxin Oral Solution: A Comprehensive Review. Nutrients. 2020 Aug; 12(9):. doi: 10.3390/nu12092661. [PMID: 32878230]
  • Christina Spry, Leanne Barnard, Michélle Kok, Andrew K Powell, Darvina Mahesh, Erick T Tjhin, Kevin J Saliba, Erick Strauss, Marianne de Villiers. Toward a Stable and Potent Coenzyme A-Targeting Antiplasmodial Agent: Structure-Activity Relationship Studies of N-Phenethyl-α-methyl-pantothenamide. ACS infectious diseases. 2020 07; 6(7):1844-1854. doi: 10.1021/acsinfecdis.0c00075. [PMID: 32375471]
  • Lucille Pourcel, Flavien Buron, Fanny Garcia, Margaux-Sarah Delaloix, Valérie Le Fourn, Pierre-Alain Girod, Nicolas Mermod. Transient vitamin B5 starving improves mammalian cell homeostasis and protein production. Metabolic engineering. 2020 07; 60(?):77-86. doi: 10.1016/j.ymben.2020.03.008. [PMID: 32247827]
  • Zhuo Wang, Weixiao Nan, Huazhe Si, Shiyong Wang, Haihua Zhang, Guangyu Li. Pantothenic acid promotes dermal papilla cell proliferation in hair follicles of American minks via inhibitor of DNA Binding 3/Notch signaling pathway. Life sciences. 2020 Jul; 252(?):117667. doi: 10.1016/j.lfs.2020.117667. [PMID: 32304761]
  • Nashwah Ismail, Nina Kureishy, Stephanie J Church, Melissa Scholefield, Richard D Unwin, Jingshu Xu, Stefano Patassini, Garth J S Cooper. Vitamin B5 (d-pantothenic acid) localizes in myelinated structures of the rat brain: Potential role for cerebral vitamin B5 stores in local myelin homeostasis. Biochemical and biophysical research communications. 2020 01; 522(1):220-225. doi: 10.1016/j.bbrc.2019.11.052. [PMID: 31759626]
  • S J Nisbet, D Targett, A V Rawlings, K Qian, X Wang, C B Lin, M A Thompson, P A Bulsara, D J Moore. Clinical and in vitro evaluation of new anti-redness cosmetic products in subjects with winter xerosis and sensitive skin. International journal of cosmetic science. 2019 Dec; 41(6):534-547. doi: 10.1111/ics.12559. [PMID: 31309600]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Joy E Chiu, Jose Thekkiniath, Sameet Mehta, Christoph Müller, Franz Bracher, Choukri Ben Mamoun. The yeast pantothenate kinase Cab1 is a master regulator of sterol metabolism and of susceptibility to ergosterol biosynthesis inhibitors. The Journal of biological chemistry. 2019 10; 294(40):14757-14767. doi: 10.1074/jbc.ra119.009791. [PMID: 31409644]
  • Joost Schalkwijk, Erik L Allman, Patrick A M Jansen, Laura E de Vries, Julie M J Verhoef, Suzanne Jackowski, Peter N M Botman, Christien A Beuckens-Schortinghuis, Karin M J Koolen, Judith M Bolscher, Martijn W Vos, Karen Miller, Stacy A Reeves, Helmi Pett, Graham Trevitt, Sergio Wittlin, Christian Scheurer, Sibylle Sax, Christoph Fischli, Iñigo Angulo-Barturen, Mariá Belén Jiménez-Diaz, Gabrielle Josling, Taco W A Kooij, Roger Bonnert, Brice Campo, Richard H Blaauw, Floris P J T Rutjes, Robert W Sauerwein, Manuel Llinás, Pedro H H Hermkens, Koen J Dechering. Antimalarial pantothenamide metabolites target acetyl-coenzyme A biosynthesis in Plasmodium falciparum. Science translational medicine. 2019 09; 11(510):. doi: 10.1126/scitranslmed.aas9917. [PMID: 31534021]
  • Okan Aydın, Faruk Pehlivanlı, Gökhan Karaca, Gülçin Aydın, Canan Altunkaya, Huri Bulut. May dexpanthenol, platelet-rich plasma, and thymoquinone provide new hope to maintain liver regeneration after partial hepatectomy?. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology. 2019 Sep; 30(9):826-834. doi: 10.5152/tjg.2019.18697. [PMID: 31530526]
  • Gokhan Zengin, Mehmet Yavuz Paksoy, Muhammad Zakariyyah Aumeeruddy, Jasmina Glamocilja, Marina Sokovic, Alina Diuzheva, József Jekő, Zoltán Cziáky, Maria João Rodrigues, Luisa Custodio, Mohamad Fawzi Mahomoodally. New insights into the chemical profiling, cytotoxicity and bioactivity of four Bunium species. Food research international (Ottawa, Ont.). 2019 09; 123(?):414-424. doi: 10.1016/j.foodres.2019.05.013. [PMID: 31284993]
  • Osman Sutcuoglu, Mehmet Kursat Derici, Ozge Tugce Pasaoglu, Burak Dumludag, Ozant Helvacı, Betul Ogut, Ipek Isık Gonul, Ulver Derici. Is it possible to prevent contrast-induced nephropathy with dexpanthenol?. International urology and nephrology. 2019 Aug; 51(8):1387-1394. doi: 10.1007/s11255-019-02194-2. [PMID: 31190296]
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